Academic literature on the topic 'Antifungal agents industry'

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Journal articles on the topic "Antifungal agents industry"

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Álvarez, Micaela, Alicia Rodríguez, Elena Bermúdez, Elia Roncero, and María J. Andrade. "Development of a Methodology for Estimating the Ergosterol in Meat Product-Borne Toxigenic Moulds to Evaluate Antifungal Agents." Foods 10, no. 2 (February 17, 2021): 438. http://dx.doi.org/10.3390/foods10020438.

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Antifungal agents are commonly used in the meat industry to prevent the growth of unwanted moulds, such as toxigenic ones, on dry-cured meat products. For enhancing the application of antifungals, their mode of action must be evaluated. Their effect on the mould ergosterol content is one of the most studied ones, since it is the target site of some commercialised antifungals or of those that are in development. The aim of this study was to develop a methodology for determining how the antifungal agents used in the meat industry work. A method for analysing ergosterol was firstly developed using high-performance liquid chromatography with fluorescence detection coupled to a diode array detector (HPLC-FLD/DAD). The chromatographically optimised conditions (gradient and mobile phases) allowed us to reduce the time per analysis with respect to previously published methods up to 22 min. Withing the six checked extraction methods, method 5, showing the best mean recovery values (99.51%), the shortest retention time (15.8 min), and the lowest standard deviation values (9.92) and working temperature (60 °C), was selected. The limit of detection and limit of quantification were 0.03 and 0.1 µg/mL, respectively. All the validation parameters corroborated the method’s suitability. Finally, its feasibility for evaluating the effect of a commercial antifungal preparation (AP) and different herbs that are frequently added to meat products on the ergosterol content of several toxigenic moulds was studied. Differences at the strain level were obtained in the presence of AP. Moreover, the addition of herbs significantly reduced the ergosterol content in Penicillium nordicum up to 83.91%. The developed methodology is thus suitable for screening the antifungals’ role in altering mould ergosterol biosynthesis before their application in real meat products.
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Torrijos, Raquel, Tiago de Melo Nazareth, Juan Manuel Quiles, Jordi Mañes, and Giuseppe Meca. "Application of White Mustard Bran and Flour on Bread as Natural Preservative Agents." Foods 10, no. 2 (February 16, 2021): 431. http://dx.doi.org/10.3390/foods10020431.

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In this study, the antifungal activity of white mustard bran (MB), a by-product of mustard (Sinapis alba) milling, and white mustard seed flour (MF) was tested against mycotoxigenic fungi in the agar diffusion method. The results obtained were posteriorly confirmed in a quantitative test, determining the minimum concentration of extract that inhibits the fungal growth (MIC) and the minimum concentration with fungicidal activity (MFC). Since MF demonstrated no antifungal activity, the MB was stored under different temperature conditions and storage time to determine its antifungal stability. Finally, an in situ assay was carried out, applying the MB as a natural ingredient into the dough to avoid P. commune CECT 20767 growth and increase the bread shelf life. The results demonstrated that the antifungal activity of MB was dose-dependent. The higher assayed dose of MB (10 g/kg) reduced the fungal population in 4.20 Log CFU/g regarding the control group. Moreover, the shelf life was extended four days compared to the control, equaling its effectiveness with the synthetic preservative sodium propionate (E-281). Therefore, MB could be an alternative to chemical additives in bread formulations since it satisfies consumer requirements. Also, the formulation of bread with MB valorizes this by-product generated during mustard seed milling, thereby helping the industry move forward sustainably by reducing environmental impact.
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Muñoz-Tebar, Nuria, Emilio J. González-Navarro, Teresa María López-Díaz, Jesús A. Santos, Gonzalo Ortiz de Elguea-Culebras, M. Mercedes García-Martínez, Ana Molina, Manuel Carmona, and María Isabel Berruga. "Biological Activity of Extracts from Aromatic Plants as Control Agents against Spoilage Molds Isolated from Sheep Cheese." Foods 10, no. 7 (July 7, 2021): 1576. http://dx.doi.org/10.3390/foods10071576.

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The aim of this work was to assess the antifungal and antioxidant activity of essential oils and ethanolic extracts from distilled solid by-products from aromatic plants (Artemisia dracunculus, Hyssopus officinalis, Lavandula stoechas, Origanum vulgare and Satureja montana) against 14 fungi strains isolated from sheep cheese and identified at species level using DNA barcoding based on β-tubulin sequence analysis. In addition, capacity of fungi to produce ochratoxin A, patulin, cyclopiazonic acid and sterigmatocystin was analyzed. Of the isolates, 85.7% belonged to Penicillium (P. commune/biforme, P. crustosum) and 14.3% to Aspergillus (A. puulaauensis and A. jensenii), the first time that these Aspergillus species have been found in sheep’s cheese. All P. commune isolates were producers of cyclopiazonic acid, and the two Aspergillus strains produced sterigmatocystin, but the others did not produce any tested mycotoxin. Among the essential oils tested, oregano, savory and tarragon had a significant antifungal activity against all the isolated strains, but no ethanolic extract showed antifungal activity. By contrast, ethanolic extracts showed great potential as antioxidants. The identification of new molds in cheese will help the dairy industry to know more about those molds affecting the sector, and the use of aromatic plants in the control of fungal spoilage could be a suitable alternative to chemical preservatives used in the agri-food industry.
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4

Thambidurai, Punitha, Vinodhini Raja, Saranya Ashokapuram Selvam, Moorthy Kannaiyan, and Gnanendra Shanmugam. "Prioritization of Drugs for Fungal Keratitis Eye Infections: An In-Silico Analysis." Applied Sciences 9, no. 12 (June 18, 2019): 2485. http://dx.doi.org/10.3390/app9122485.

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The fungal keratitis (FK) infections that cause cornea inflammations are more virulent than other bacterial keratitis infections and remain one of the most ethereal and challenging infections for ophthalmologists to diagnose and treat. Thus, the urgency in understanding the current perspectives of antifungal agents and their interactions with novel therapeutic targets and the identification of novel anti-fungal agents are at the frontline of studies in the pharmaceutical industry. In this study, DNA dependent RNA polymerase was modelled and virtually screened against eight antifungal agents, and it was found that Itraconazole (−22.0427 kJ/mol), Ketoconazole (−20.2194 kJ/mol), and Voriconazole (−12.6388 kJ/mol) exhibited better binding interactions. further, the structural and electronic properties of Itraconazole calculated through density functional theory studies revealed the sites of chemical reactivity that are vital in the compounds for possible interactions with RNA polymerase (RNAP). Hence, this study explores the binding efficacies of various anti-fungal agents through docking studies and their chemical entities, which might pave a significant path for the design of novel anti-fungal agents against hyalohyphomycetes causing keratitis.
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5

M.Sunar, N., M. Subramaniam, N. F. Zulkifly, U. K. Parjo, C. M. Er, A. M. Leman, A. Khalid, et al. "Indoor Fungal Growth on Variable Antifungal at Different Wall Finishing on Plasterboard." International Journal of Engineering & Technology 7, no. 3.23 (August 9, 2018): 53. http://dx.doi.org/10.14419/ijet.v7i3.23.17260.

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Various health complaints often been attributed to pollution and the poor quality of the indoor air. If there is good practice in building design, construction, and maintenance, the structures should remain dry. However, when there is moisture damage, the materials may be in contact with water for prolonged times, which inevitably leads to microbial growth or even total deterioration of the building material. Antimicrobial coating is designed to generate a surface that is easy to clean and can also incorporate active agents, commonly called antifungal, that prevent microbial colonization, the subsequent growth and bio-deterioration of the substrate. This paper presents the sustainable treatment for indoor environment quality in buildings by examining the application of potassium sorbate, zinc salicylate, and calcium benzoate that used as food industry preservatives as indoor antimicrobial agents. Four types of wall finishing used on plasterboard substrate: acrylic paint, glycerol based-paint, thin wallpaper, and thick wallpaper. The result indicated that potassium sorbate is the best bio compound to react as antifungal agent to prohibit the growth of indoor fungi. All the antifungal shows difference level of their effectiveness from each other. Only 40% of fungi were able to grow on thin wallpaper by using potassium sorbate as antifungal agent.
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Palou, Lluís, Silvia Valencia-Chamorro, and María Pérez-Gago. "Antifungal Edible Coatings for Fresh Citrus Fruit: A Review." Coatings 5, no. 4 (December 4, 2015): 962–86. http://dx.doi.org/10.3390/coatings5040962.

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According to their origin, major postharvest losses of citrus fruit are caused by weight loss, fungal diseases, physiological disorders, and quarantine pests. Cold storage and postharvest treatments with conventional chemical fungicides, synthetic waxes, or combinations of them are commonly used to minimize postharvest losses. However, the repeated application of these treatments has led to important problems such as health and environmental issues associated with fungicide residues or waxes containing ammoniacal compounds, or the proliferation of resistant pathogenic fungal strains. There is, therefore, an increasing need to find non-polluting alternatives to be used as part of integrated disease management (IDM) programs for preservation of fresh citrus fruit. Among them, the development of novel natural edible films and coatings with antimicrobial properties is a technological challenge for the industry and a very active research field worldwide. Chitosan and other edible coatings formulated by adding antifungal agents to composite emulsions based on polysaccharides or proteins and lipids are reviewed in this article. The most important antifungal ingredients are selected for their ability to control major citrus postharvest diseases like green and blue molds, caused by Penicillium digitatum and Penicillium italicum, respectively, and include low-toxicity or natural chemicals such as food additives, generally recognized as safe (GRAS) compounds, plant extracts, or essential oils, and biological control agents such as some antagonistic strains of yeasts or bacteria.
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7

Matei, Gabi Mirela, Sorin Matei, Adrian Matei, and Elena Draghici. "Antifungal activity of a biosurfactant-producing lactic acid bacteria strain." EuroBiotech Journal 1, no. 3 (July 20, 2017): 212–16. http://dx.doi.org/10.24190/issn2564-615x/2017/03.02.

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Abstract Lactic acid bacteria are frequently utilized in food industry and they are also recognized as antimicrobial agents due to their capability to produce metabolites such as: organic acids, biosurfactants, bacteriocins, hydrogen peroxide, cyclic dipeptides, exopolysaccharides. The main goal of this paper was to present the results of the research carried out on the strain LCM2 of lactic acid bacteria isolated from brined cucumbers, for production of biosurfactants and to assess its antifungal properties. The emulsification capacity of biosurfactant was measured using kerosene as the hydrophobic substrate. The value of emulsification index E24 was 89.04% showing a high emulsification activity of the biosurfactant. The structural characterization of biosurfactant by TLC revealed its glycolipidic nature. Assay of the ionic charge established the anionic charge of the biosurfactant revealed by the presence of precipitation lines towards the cationic surfactant dodecyl-dimethyl-ammonium chloride. The biosurfactant presented antibiofilm activity with low adherence capacity, structural damages of the hyphal net, conidiophores and delays or lack of sporulation and decreased biomass accumulation in four mycotoxigenic Penicillium and Aspergillus isolates. Results of in vitro assays recommend the biosurfactant produced by the new lactic acid bacteria strain LCM2 for biotechnological purposes, as alternative antifungal agent in food industry.
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8

Dopazo, Victor, Carlos Luz, Jordi Mañes, Juan Manuel Quiles, Raquel Carbonell, Jorge Calpe, and Giuseppe Meca. "Bio-Preservative Potential of Microorganisms Isolated from Red Grape against Food Contaminant Fungi." Toxins 13, no. 6 (June 10, 2021): 412. http://dx.doi.org/10.3390/toxins13060412.

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Fungal spoilage is one of the main reasons of economic losses in the food industry, especially in the wine sector. Consequently, the search for safer and new preservation techniques has gained importance in recent years. The objective of this study was to investigate the antifungal and anti-mycotoxigenic activity from 28 microorganisms (MO) isolated from red grape. The antifungal activity of a cell free supernatant of fermented medium by the isolated MO (CFS) was tested with the agar diffusion method and the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) assay. Additionally, different antifungal compounds from the CFS were identified and quantified (organic acids, phenolic compounds, and volatile organic compounds). Finally, the most active CFS were tested as red grape bio-preservative agents. Results evidenced that CFS fermented by the strain UTA 6 had the highest antifungal activity, above all isolates, and produced a wide pool of antifungal compounds. The use of UTA 6 CFS as bio-preservative agent showed a reduction of 0.4 and 0.6 log10 spores per gram of fruit in grapes contaminated by A. flavus and B. cinerea, respectively. Moreover, UTA 6 CFS treatment reduced the occurrence of aflatoxin B1 and fumonisin (B2, B3, and B4) production in grapes contaminated by 28–100%.
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9

Jadhav, P. M. "A review on biological activities of Schiff base ligand and their metal complexes." International Journal of ChemTech Research 13, no. 1 (2020): 217–21. http://dx.doi.org/10.20902/ijctr.2019.130126.

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Schiff bases and their metal complexes are wide range of biological applications and are synthesized from the condensation reaction of amino compounds with carbonyl compounds. Schiff base and their metal complexes have a wide variety of applications in food and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, antiinflammatory activity, antiradical activity, and biological system as enzymatic agents. Several have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic activities. This review summarized the most promising biological activities of Schiff bases and their metal complexes
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10

Nayarisseri, Anuraj. "Most Promising Compounds for Treating COVID-19 and Recent Trends in Antimicrobial & Antifungal Agents." Current Topics in Medicinal Chemistry 20, no. 24 (November 2, 2020): 2119–25. http://dx.doi.org/10.2174/156802662023201001094634.

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Multidrug resistance in microbes poses a major health crisis and demands for the discovery of novel antimicrobial agents. The recent pandemic of SARS-CoV-2 has raised a public health emergency in almost all the countries of the world. Unlike viruses, a bacterium plays a significant role in various environmental issues such as bioremediation. Furthermore, biosurfactants produced by various bacterial species have an edge over traditionally produced chemical surfactants for its biodegradability, low toxicity and better interfacial activity with various applications in agriculture and industry. This special issue focuses on the global perspective of drug discovery for various antimicrobial, antiviral, and antifungal agents for infectious diseases. The issue also emphasizes the ongoing developments and the role of microbes in environmental remediation. We wish the articles published in this issue will enhance the current understanding in microbiology among the readers, and serve as the "seed of an idea" for drug development for ongoing COVID-19 pandemic.
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Books on the topic "Antifungal agents industry"

1

Constance, Joseph. The world market for anti-infectives. Edited by Heffner Steven and Kalorama Information LLC. New York: Kalorama Inofrmation, 2002.

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2

Co, Business Communications. The Market for Antifungal Drugs. Business Communications Company, 2003.

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(Firm), Find/SVP, ed. The international market for antifungals. New York: Find/SVP, 1996.

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U.S. antifungal markets: High-growth era for systemic and OTC products. Mountain View, CA: Frost & Sullivan, 1994.

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Innes, George L. Biocides (Business opportunity report). Business Communications Co, 2000.

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Bassett, Pamela. Antibacterials and antifungals: Technologies, trends and market opportunities (D & MD reports). 2nd ed. D & MD, 2001.

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