Academic literature on the topic 'Antifungal and antibacterial activity'
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Journal articles on the topic "Antifungal and antibacterial activity"
Khan, M. R., and A. D. Omoloso. "Antibacterial, antifungal activity of Harpullia petiolaris." Fitoterapia 73, no. 4 (July 2002): 331–35. http://dx.doi.org/10.1016/s0367-326x(02)00077-1.
Full textMajiene, D., S. Trumbeckaite, A. Pavilonis, A. Savickas, and D. Martirosyan. "Antifungal and Antibacterial Activity of Propolis." Current Nutrition & Food Science 3, no. 4 (November 1, 2007): 304–8. http://dx.doi.org/10.2174/1573401310703040304.
Full textAnnenkova, V. Z., M. G. Voronkov, and V. M. Annenkova. "Antibacterial and antifungal activity of feracryl." Pharmaceutical Chemistry Journal 31, no. 3 (March 1997): 145–46. http://dx.doi.org/10.1007/bf02464668.
Full textPanneerselvam, P., and G. Geete Ganesh. "Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives." E-Journal of Chemistry 8, s1 (2011): S149—S154. http://dx.doi.org/10.1155/2011/905643.
Full textHuang, Han-Fen, and Chien-Fang Peng. "Antibacterial and antifungal activity of alkylsulfonated chitosan." Biomarkers and Genomic Medicine 7, no. 2 (June 2015): 83–86. http://dx.doi.org/10.1016/j.bgm.2014.09.001.
Full textWilkinson, Jenny M., Michael Hipwell, Tracey Ryan, and Heather M. A. Cavanagh. "Bioactivity ofBackhousia citriodora: Antibacterial and Antifungal Activity." Journal of Agricultural and Food Chemistry 51, no. 1 (January 2003): 76–81. http://dx.doi.org/10.1021/jf0258003.
Full textLiu, H., X. L. Yang, J. Y. Ding, Y. D. Feng, and H. B. Xu. "Antibacterial and antifungal activity of Erigeron breviscapus." Fitoterapia 74, no. 4 (June 2003): 387–89. http://dx.doi.org/10.1016/s0367-326x(03)00068-6.
Full textEl Amraoui, B., M. El Amraoui, N. Cohen, and A. Fassouane. "Antifungal and antibacterial activity of marine microorganisms." Annales Pharmaceutiques Françaises 72, no. 2 (March 2014): 107–11. http://dx.doi.org/10.1016/j.pharma.2013.12.001.
Full textErdemoglu, Nurgün, Gökalp Iscan, Bilge Sener, and Prasit Palittapongarnpim. "Antibacterial, antifungal, and antimycobacterial activity ofIlex aquifoliumleaves." Pharmaceutical Biology 47, no. 8 (June 12, 2009): 697–700. http://dx.doi.org/10.1080/13880200902930431.
Full textHaruna, Muyideen. "Antibacterial and Antifungal Activity of Acalypha wilkesiana." European Journal of Medicinal Plants 3, no. 1 (January 10, 2013): 52–64. http://dx.doi.org/10.9734/ejmp/2013/2220.
Full textDissertations / Theses on the topic "Antifungal and antibacterial activity"
Mohammadihashemi, Marjan. "Antibacterial and Antifungal Activity of Ceragenins, Mimics of Endogenous Antimicrobial Peptides." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7411.
Full textMogashoa, Motanti Mary. "Isolation and characterisation of antifungal and antibacterial compounds from Combretum molle (Combretaceae) leaf extracts." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/60270.
Full textDissertation (MSc)--University of Pretoria, 2017.
Paraclinical Sciences
MSc
Unrestricted
Alasmary, Fatmah A. S. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents. An investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.
Full textSaudi Culture Bureau and King Saud University
Alasmary, Fatmah Ali Saeed. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents : an investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.
Full textŽevžikovienė, Augusta. "Naujų 4-tiazolidinonų, turinčių sulfanilamido, alilamino ir nitrofurano farmakoforus, priešmikrobinių savybių tyrimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120918_161940-39143.
Full textMore than 200 antimicrobial agents are used in clinical practice for the treatment of infectious diseases, however, infectious diseases are still one of the most common causes of death, and the need for new antimicrobials isn’t decreasing. Compounds with different biological activity are synthesized by modifying 4-thiazolidinone. 4-thiazolidinones with sulfanilamide pharmacophore are more active against bacteria than sulfanilamides, and are characterized as antifungals. 4-thiazolidinones with nitrofuran pharmacophore are one of the most active antimicrobials. Higher antimicrobial activity of new compounds was expected after attaching allylamine to the molecule together with the previously known pharmacophores. By applying the selected methodologies for the synthesis of new 4-thiazolidinones with the fragments of selected pharmacophores (sulfanilamide, nitrofurane, allylamine), 39 derivatives of 4-thiazolidinone were synthesized. The assessment of physico-chemical properties and toxicity risk in silico helped to determine the value of compounds as biologically active substances. In silico and in vitro studies confirmed that new 4-thiazolidinone’s with sulfanilamide, nitrofurane and allylamine pharmacophores showed antimicrobial activity against various bacteria (S. aureus, E. faecalis, E. coli, P. aeruginosa, K. pneumonia, B. subtilis, P. mirabilis) and fungal cultures of C.albicans. Summarising microbiological tests, the most active antibacterial and antifungal compounds... [to full text]
Peter, Cristina Mendes. "Atividade antimicrobiana de extratos hidroalcoólicos de própolis marrom, verde e de abelhas jataí (Tetragonisca angustula) frente a micro-organismos infecciosos de interesse em Medicina Veterinária e Humana." Universidade Federal de Pelotas, 2015. http://repositorio.ufpel.edu.br:8080/handle/prefix/3379.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
O objetivo deste estudo foi avaliar a atividade antimicrobiana (antibacteriana, antifúngica e antiviral), toxicidade celular e composição química de extratos hidroalcoólicos da própolis marrom (PM), verde (PV) e de abelhas nativas jataí (PJ). A atividade antibacteriana da própolis foi analisada pelo método de Microdiluição frente à Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae e Escherichia coli. Para a atividade antifúngica, foi utilizada metodologia semelhante, frente à Candida lipolytica, Candida parapsilosis, Sporothrix schenckii e Sporothrix brasiliensis. A atividade antiviral foi avaliada através de dois métodos distintos de tratamento das células com os extratos: antes e depois da inoculação viral, frente ao Herpes Vírus Bovino (BoHV-1) e ao Vírus da Diarreia Viral Bovina (BVDV) e quantificado pelo teste de MTT (3-(4,5 dimetiltiazol-2yl)- 2-5-difenil-2H tetrazolato de bromo) e a atividade virucida, avaliada através de diferentes diluições dos vírus, temperaturas e tempos de incubações e analisadas por observação microscópica e quantificadas através da Dose Infectante (D.I.) 50%. A toxicidade foi avaliada através de diferentes concentrações e a viabilidade celular quantificada por MTT. À composição química das própolis foi determinada por Cromatografia Líquida de Alta Eficiência (CLAE). Os resultados da atividade antibacteriana demonstraram que PM obteve valores menores de Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM), quando testados frente à S. aureus (6,7 mg/mL; 13,4 mg/mL, respectivamente), e E. coli (29,4 mg/mL; 54,3 mg/mL) quando comparados ao PV e PJ. Contudo frente Streptococcus sp., os menores valores de CIM e CBM encontrados foram da PV (p<0,01). Na atividade antifúngica as PM, PV e PJ apresentaram eficácia à Candida sp. eSporotrix sp. A PJ apresentou menor toxicidade, em sequência PV e PM. Na atividade antiviral, os extratos foram mais eficazes quando acrescentados no pré-tratamento e a PM e PV foram mais eficazes ao BoHV-1, enquanto a PJ ao BVDV. Na virucida, a PVa 37°C obteve valores diferentes e menores (log = 2,67) em relação a PM (log = 3,5) e PJ (log = 3,76). No entanto, para BVDV a PJ apresentou os melhores resultados para ambas temperaturas. Os resultados demonstram o potencial da própolis como antimicrobiano no tratamento de doenças em Medicina Veterinária e Humana.
The objective of this study was to evaluate the antimicrobial activity (antibacterial, antifungal and antiviral), cell toxicity and chemical composition of hydroalcoholic extracts of brown propolis (PM), green (PV) and native bees jataí (PJ). The antibacterial activity of propolis was analyzed by microdilution method against the Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae and Escherichia coli. For the antifungal activity, similar methodology was used, compared to Candida lipolytica, Candida parapsilosis, Sporothrix schenckii and Sporothrix brasiliensis. The antiviral activity was measured using two different methods of treatment of the cells with the extracts: before and after the viral inoculation against Bovine Herpes virus (bovine herpesvirus type 1) and Bovine Viral Diarrhea Virus (BVDV) and quantitated by assaying MTT (3- (4,5 dimethylthiazol-2yl) - 2,5-diphenyl-2H-tetrazolato bromine) and virucidal activity, measured using different dilutions of virus, temperatures and incubation times and analyzed by microscopic observation and quantified by the infective dose (ID) 50%. Toxicity was evaluated using different concentrations and cell viability measured by MTT. In the chemical composition of propolis was determined by High Performance Liquid Chromatography (HPLC) methods. The results demonstrated that the antibacterial activity had lower values PM Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) when tested against S. aureus (6.7 mg/mL; 13.4 mg/mL, respectively) and E. coli (29.4 mg/mL, 54.3 mg/mL) compared to the PV and PJ. However front Streptococcus sp., the lowest values of MIC and MBC were found of PV (p <0.01). In the antifungal activity PM, PV and PJ showed efficacy to Candida sp. and Sporotrix spp. The PJ showed lower toxicity in PV and PM sequence. In the antiviral activity, the extracts were more effective when added in the pre treatment and the PM and PV were more effective in BoHV-1, while the PJ to BVDV. In virucidal, PV obtained at 37°C and under different values (log = 2.67) compared to PM (log = 3.5) and PJ (log = 3.76). However, for BVDV PJ showed the best results for both temperatures. Results show the potential of propolis as an antimicrobial in the treatment of diseases in Veterinary Medicine and Human.
Camargo, Marlene Rodrigues Marcelino. "Avaliação da atividade antimalárica e antimicrobiana de geissosperum argenteum Woodson e Minguartia guianensis Aubl coletadas em Roraima." Universidade Federal de Roraima, 2011. http://www.bdtd.ufrr.br/tde_busca/arquivo.php?codArquivo=130.
Full textDentre as espécies florestais nativas da Amazônia utilizadas por populações tradicionais na terapêutica de diversos problemas de saúde estão a Geissospermum argenteum Woodson, uma Apocynaceae, e a Minquartia guianensis Aubl., da família Olacaceae. Entre os problemas de saúde está a malária, que no Brasil e no mundo ainda é um grave problema de saúde pública. Outro agravo à saúde de importância são infecções microbianas, pois os micro-organismos têm desenvolvido resistência aos agentes antimicrobianos. Neste trabalho, foram coletadas amostras de cascas, folhas e galhos de G. argenteum e M. guianensis, em área de floresta, na Vila Apiaú, município de Mucajaí RR. As amostras foram submetidas à extração metanólica a quente e extração aquosa, Amostra de extrato metanólico de cascas de G. argenteum foi submetida a particionamento líquido-líquido, resultando nas frações hexânica, clorofórmica, acetato de etila e metanol/água. A fração clorofórmica foi selecionada para cromatografia em coluna com sistema gradiente de solventes, obtendo-se 38 frações, as quais foram analisadas através de CCD e destas a fração Cr10 foi selecionada para cromatografia preparativa, a partir da qual foi obtida a fração F6, que analisada em CCD mostrou-se positiva para alcalóides. Os extratos metanólicos e aquosos de ambas as espécies, e frações primárias provenientes de extratos G. argenteum foram testados em ensaios in vitro para atividade antimalárica frente à cepa cloroquino-resistente, K1, de Plasmodium falciparum, nas concentrações de 50 e 5 μg/mL. Posteriormente, amostras ativas foram avaliadas em 7 diluições para estabelecer a relação dose-resposta e valores de concentração inibitória mediana (CI50). Amostras provenientes das duas espécies também foram testadas contra as cepas bacterianas, Staphylococcus aureus, Streptococcus mutans e Escherichia coli, e contra a levedura Candida albicans. A atividade antimicrobiana foi avaliada através de difusão em ágar e a concentração inibitória mínima (CIM) por microdiluição em placas. Para as frações acetato de etila, clorofórmica, hexânica e hidroalcoólica obtida de cascas de G. argenteum e a fração Cr10 foi realizada a bioautografia para S. aureus. Na atividade antimalárica o extrato metanólico de casca foi ativo, com CI50 de 4,6 μg/mL e a fração clorofórmica obtida de casca de G. argenteum também foi ativa com CI50 de 2,0 μg/mL. Os extratos de M. guianensis foram considerados inativos para a atividade antimalárica. Na atividade antimicrobiana, através de difusão em ágar, extratos de G. argenteum foram parcialmente ativos contra S. aureus, S. mutans e inativos contra E. coli e C. albicans. A CIM para S. aureus foi de 0,63 mg/mL para a fração metanol/água, para S. mutans, CIM de 0,63 mg/mL e C. albicans com CIM de 0,63 mg/mL. Para cepa de E. coli os extratos foram inativos. Extratos de M. guianensis mostraram-se ativos frente à S. aureus e C. albicans através de difusão em ágar e apresentaram a CIM superior a 1mg/ml para S. aureus, S. mutans e C. albicans. Os extratos de M. guianensis foram inativos contra E. coli. Na autobiografia para S. aureus as frações testadas apresentaram atividade.
Among the natives species from the Amazon Forest used by traditional populations in the treatment of various health problems, including, malaria, wich in Brazil and in the world remains a serious public health problem, are Geissospermum argenteum Woodson, an Apocynaceae, and Minquartia guianensis Aubl, Olacaceae family. Another important health problem is the microbial infections, because the microorganisms have developed resistence to antimicrobial agents. In this work, samples were collected from bark, leaves and twigs of G.argenteum and M. guianensis in a forestall area in Apiaú village, city of Mucajaí RR. The samples were extracted by hot methanol and water extraction, resulting in methanol and aqueous extracts. Sample of methanol extract of bark of G.argenteum was submitted to liquid-liquid partitioning, resulting in fractions hexane, chloroform, ethyl acetate and methanol/water. The chloroform fraction was selected for fractionation using chromatography colunn and solvent gradient system, resulting in 38 fractions, which were analyzed by TLC and the fraction Cr10 was selected for preparative chromatography, from which the fraction F6 was obtained, analyzed in CCD was positive for alkaloids. The methanol and aqueous extracts of both species and fractions of extracts from primary G.argenteum were tested in vitro assays for antimalarial activity against the chlroquine-resistant K1 Plasmodium falciparum at concentrations of 50 and 5 mg/mL. Subsequently, active samples were evaluated in 7 diluitions to establish the dose-response and median inhibitory concentration values (IC50). Samples from two species were also tested against bacterial strains, Staphylococcus aureus, Streptococcus mutans and Escherichia coli, and against the yeast Candida albicans. Antimicrobial activity was evaluated by agar diffusion and minimum inhibitory concentration (MIC) by microdilution plates. For fractions of ethyl acetate, chloroform, hexane and water-alcohol obtained from barks of G.argenteum, fraction Cr10 and bioautography was performed fo S. aureus. Antimalarial activity in the methanol extract of bark was active, with IC50 of 4,6 mg/mL and chloroform fraction obtained from bark of G.argenteum was also active with IC50 of 2,0 mg/mL. The extracts of M. guianensis were considered inactive for antimalarial activity. In antimicrobial activity by agar diffusion, extracts of G.argenteum were partially active against S. aureus, S. mutans and inactive against E. coli and C. albicans. The MIC for S. aureus was 0,63 mg/mL per fraction methanol/water, S. mutans, MIC of 0,63 mg/mL and C. albicans with an MIC of 0,63 mg/mL. For the strain of E.coli there was no activity. Extracts of M. guianensis were active against the S. aureus and C. albicans by agar diffusion and presented more than 1 mg/mL MIC for S aureus, S.mutans and C. albicans. The extracts of M. guianensis were inactive against E. coli.
Cunha, Let?cia Figueiredo. "Plantas do cerrado brasileiro: triagem fitoqu?mica e de atividades biol?gicas de esp?cies nativas do munic?pio de Diamantina, regi?o do Vale do Jequitinhonha, Minas Gerais." UFVJM, 2016. http://acervo.ufvjm.edu.br/jspui/handle/1/1433.
Full textData de aprova??o ausente.
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As plantas, por serem fonte de subst?ncias biologicamente ativas, s?o utilizadas com a finalidade terap?utica desde o in?cio da civiliza??o humana. O Brasil, por sua vez, ? detentor de uma vasta diversidade biol?gica e possui uma grande quantidade de esp?cies vegetais com potencial medicinal. Dentre os diversos biomas do territ?rio brasileiro, o Cerrado representa o segundo maior, registrando-se muitas esp?cies medicinais. Apesar de sua rica biodiversidade muitas plantas end?micas deste bioma foram pouco estudadas do ponto de vista qu?mico e biol?gico. Consequentemente, ? necess?rio maior investimento em pesquisas com plantas medicinais para tratamento de doen?as, principalmente, as cr?nicas degenerativas e parasit?rias, como Doen?a de Chagas, Leishmanioses, C?ncer e as infec??es causadas por bact?rias e fungos, cujo o tratamento apresenta importantes limita??es. Assim, o objetivo deste estudo foi realizar a triagem fitoqu?mica e de atividades biol?gicas de extratos etan?licos de 12 esp?cies de plantas oriundas do Cerrado, coletadas no mun?cipio de Diamantina, Vale do Jequitinhonha/MG. Para a triagem fitoqu?mica preliminar destes extratos foram realizadas rea??es cromog?nicas, de precipita??es e an?lises em cromatografia em camada delgada comparativa (CCDC). A citotoxicidade para c?lulas normais de mam?feros foi avaliada em fibroblastos de camundongos (L929). A linhagem celular de c?ncer de mama MDA-MB-231 foi a utilizada para a avalia??o da atividade antitumoral dos extratos. A avalia??o da atividade antitripanossomat?deo foi realizada sobre formas epimastigotas da cepa Colombiana de Trypanossoma cruzi e, sobre as formas promastigotas das cepas BH46 de Leishmania (leishmania) infantum e cepa M2269 de Leishmania (leishmania) amazonensis. Para a avalia??o destas atividades foi empregada a t?cnica colorim?trica de MTT. A avalia??o das atividades antibacteriana e antif?ngica foi realizada por meio da determina??o da Concentra??o Inibit?ria M?nima (CIM), empregando a t?cnica colorim?trica da Resazurina. As esp?cies de bact?rias utilizadas foram Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa e Staphylococcus aureus. Na atividade antif?ngica foram utilizadas quatro esp?cies de leveduras (Candida albicans, Candida famata, Candida krusei e Candida tropicalis) e duas esp?cies de fungos filamentosos (Aspergillus niger e Penicillium expansum). Dos 13 extratos avaliados com rela??o a citotoxicidade sobre fibroblastos de camundongos da linhagem L929, todos apresentaram algum grau de citotoxicidade. Alguns destes extratos apresentaram elevada toxicidade sobre esta linhagem celular, sendo que o extrato etan?lico das folhas de E. erythropappus foi o mais t?xico. Na avalia??o da atividade antitumoral, com exce??o do extrato etan?lico das folhas de P. rigida, todos os outros extratos avaliados apresentaram atividade. Destes o mais promissor tamb?m foi o extrato etan?lico das folhas de E. erythropappus. Na avalia??o da atividade tripanocida sobre formas epimastigotas da cepa Colombiana de T. cruzi, nove extratos foram ativos contra este parasito. Destes os mais promissores foram os extratos das folhas de A. aculeata e das folhas de E. erythropappus. Na avalia??o da atividade leishmanicida para a cepa M2269 os extratos etan?licos das folhas de E. erythropappus e das folhas de B. oxyclada apresentaram como os mais promissores e, para a cepa BH46 o extrato etan?lico de toda esp?cie T. catahartica foi o mais promissor, seguido tamb?m do extrato etan?lico das folhas de E. erythropappus. Na avalia??o da atividade antibacteriana somente os extratos etan?licos das folhas de B. oxyclada, de P. tomentosa e S. rugosa foram ativos e, as ?nicas bact?rias sens?veis foram P. aeruginosa e S. aureus. Destes o extrato etan?lico de P. tomentosa inibiu um maior n?mero de bact?rias com a??o bactericida. Os fungos filamentosos, A. niger e P. expansum, se mostraram resistentes a todos os extratos avaliados e C. krusei foi a levedura mais sens?vel. Os extratos das folhas de B. oxyclada e das folhas de P. tomentosa foram os extratos que inibiram o maior n?mero de esp?cies f?ngicas com os menores valores de CIM. Atrav?s destes resultados, sugere-se que os extratos etan?licos das folhas de Eremanthus erythropappus, de Peixotoa tomentosa e de Banisteriopsis oxyclada apresentaram o maior n?mero de atividades biol?gicas e com os melhores resultados, o que torna estas esp?cies as mais promissoras como fontes potenciais de mol?culas bioativas para o tratamento de C?ncer, Doen?a de Chagas, Leishmanioses e infe??es bacterianas e f?ngicas, necessitando de mais estudos a fim de identificar as subst?ncias respons?veis por tais atividades e pela citotoxicidade e, valid?-las atrav?s de outros modelos in vitro e in vivo.
Disserta??o (Mestrado) ? Programa de P?s-gradua??o em Ci?ncias Farmac?uticas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, [2016].
Plants are a potencial source of biologically active substances and they are used for therapeutic purposes since the beginning of human civilization. Brazil, in turn, holds a vast biological diversity and has a lot of plant species with medicinal potential. Among the various biomes of Brazil, the Cerrado is the second largest, registering many medicinal species. Consequently, it is necessary to invest more in research of medicinal plants as possible new treatments, especially for the degenerative and chronic disease such as Chagas, Leishmaniasis, cancer and infections caused by bacteria and fungi, whereof treatment has big limitations. The objective of this study was the phytochemical screening and biological activities studies of ethanolic extracts of 12 plants species from the Cerrado, collected in the municipality of Diamantina, Vale do Jequitinhonha / MG.For the preliminary phytochemical screening were made chromogenic and precipitation reactions and analysis in thin-layer chromatography. Cytotoxicity for normal mammalian cells was evaluated in mouse fibroblasts (L929) and the cell line of breast cancer MDA-MB-231 was used to analyze the antitumor activity of the extracts. The evaluation of antitripanossomatideo activity was performed using epimastigotas of Colombiana Trypanosoma cruzi strain and promastigotes of BH46 Leishmania (Leishmania) infantum strain and M2269 Leishmania (Leishmania) amazonensis strain. The analyze of these activities were based at the colorimetric MTT technique. The evaluation of antibacterial and antifungal activities was performed by determining the Minimum Inhibitory Concentration (MIC) employing the colorimetric Resazurin technique. Species of bacteria used were Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus. In the antifungal activity were used four species of yeast (Candida albicans, Candida famata, Candida krusei and Candida tropicalis) and two species of filamentous fungi (Aspergillus niger and Penicillium expansum). Of the 13 extracts evaluated for cytotoxicity using the L929 strain mouse fibroblasts, all they had some cytotoxicity level. Some of these extractsthen showed a high toxicity in this assay cell line, wherein the ethanolic extract of E. erythropappus leaves was the most toxic. In the evaluation of antitumor activity all extracts showed activity, exception for the extract of P. rigida leaves. Among these the most promising was either the ethanolic extract of the leaves of E. erythropappus. Evaluation of trypanocidal activity using Colombian strain of T. cruzi epimastigotas, present active for nine extracts against this parasite, been the A. aculeata and leaves E. erythropappus leaf extract the most promising. Leishmanicidal activity for the M2269 strain of E. erythropappus B. oxyclada leaf extract presented as the most promising and, for the BH46 strain the T. catahartica role plant extract shows the best results, followed by the E. erythropappus leaf extract. In the antibacterial activity assay only the B. oxyclada, P. tomentosa and S. rugosa leaf extracts were active, and the only for P. aeruginosa and S. aureus. Among these the P. tomentosa extract inhibited a greater number of bacteria with bactericidal action. Filamentous fungus A. niger and P. expansum were resistant to all extracts evaluated and C. krusei was the most sensitive yeast. P. tomentosa and B. oxyclada leaf extracts inhibited more yeast species but with the lowest MIC values. Due these results, it is suggested that the E. erythropappus of P. tomentosa and B. oxyclada leaf ethanolic extracts showed the greatest of biological activities, making these the most promising species as potential sources of bioactive molecules for the treatment of cancer, Chagas disease, Leishmaniasis and bacterial and fungal infections, yet requiring further studies to identify the substances responsible for such activities and cytotoxicity and validate them through other models in vitro and in vivo.
Yagi, Sakina. "Etudes phytochimique et biologique de plantes soudanaises : Hydnora johannis Beccari (Hydnoraceae) et Citrullus lanatus (Thunb.) Matsum. et Nakai var. citroides (Bailey) Mansf. (Cucurbitaceae)." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10138.
Full textDifferent extracts were prepared from the roots of H. johannis and different biological tests were performed. Water extract exhibited significant activity against Enterococcus fecalis, Staphylococcus aureus and Bacillus. Water extract devoid from tannin or the tannin fraction did not show any antibacterial activity reflecting the synergistic property of active compounds. Both extracts showed antifungal, antiradical capacity as well as antiglycation activity. Toxicological study of the powder and ethanol extract on rats showed toxicity to the liver and kidney tissues. Five compounds were isolated namely; 3,4,5- Trihydroxy- 6,7-dimethoxy flavone ; 3,5-Dihydroxy- 4,7- dimethoxy dihydroflavonol, Catechin, Vanillin and Protocatechuic acid. Stigmasterol, Oleic acid, Myristic acid and Palmitic acid were also identified. A study on the fruit pulps of C. lanatus var. citroides revealed that the methanolic extract displayed an antibacterial activity against B. subtilis, S. aureus and E. coli. The butanolic extract showed antiradical capacity and was not toxic to brine shrimps larvae. Two compounds were isolated namely; Cucurbitacine E 2-O-[bêta]-glucopyranoside and Cucurbitacine L 2-O- [bêta] -glucopyranoside. Both compounds showed antibacterial activity against E.coli whereas, Cucurbitacine L 2-O-[bêta]-glucopyranoside showed antibacterial activity against P. aeruginosa as well as antiradical activity
Costa, Helen Paula Silva da. "PurificaÃÃo e caracterizaÃÃo de um inibidor de tripsina com atividade antimicrobiana da torta de pinhÃo-manso (Jatropha curcas L.)." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7773.
Full textConselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
O resÃduo (torta) obtido apÃs a extraÃÃo de Ãleo das sementes de pinhÃo-manso (Jatropha curcas) para a produÃÃo de biodiesel à tÃxico. Apesar dos entraves relacionados à sua utilizaÃÃo na alimentaÃÃo animal, existem evidÃncias de que esse resÃduo tem grande potencial de utilizaÃÃo biotecnolÃgica graÃas ao arsenal de molÃculas que o constitui. Assim, o presente trabalho teve como foco a purificaÃÃo e caracterizaÃÃo de um inibidor de tripsina da torta de pinhÃo-manso, vislumbrando um maior aproveitamento desse resÃduo. A anÃlise da composiÃÃo centesimal revelou ser a torta de pinhÃo-manso composta principalmente por proteÃnas (37,21%), fibras (34,26%) e lipÃdios (19,16%). O extrato bruto obtido a partir da torta sob condiÃÃo alcalina (tampÃo borato de sÃdio 100 mM, pH 10,0) mostrou a presenÃa de lectina (319,76 UH/gF), inibidor de papaÃna (1.287,38 UI/gF), protease (2,69 UA/gF) e, principalmente, de inibidor de tripsina (1.649,7 UI/gF). O inibidor de tripsina, denominado JcTI, foi purificado do extrato bruto por fracionamento com Ãcido tricloroacÃtico (2,5%) seguido de cromatografias de afinidade (tripsina-sepharose-4B) e de exclusÃo molecular (sephacryl S-200). JcTI à uma glicoproteÃna (6,4% de carboidratos) com massa molecular na faixa de 20-21 kDa, pI de 6,6, sequÃncia NH2-terminal (VRDICKKEAERQDLSSCENYITQRRGY) exibindo similaridade em torno de 60% com albuminas vegetais e altamente estÃvel ao calor, salinidade e pH. JcTI (500 Âg/mL) retardou o crescimento de vÃrios fungos fitopatogÃnicos de importÃncia agrÃcola, incluindo Colletotrichum gloeosporioides, Colletotrichum lindemuthianum, Fusarium oxysporum e Fusarium solani. Esse inibidor tambÃm mostrou atividade antibacteriana frente a bactÃrias patogÃnicas ao homem, tais como Bacillus subtilis, Salmonella choleraesuis e Staphylococcus aureus, com concentraÃÃo inibitÃria mÃnima inferior a 5 Âg/mL. Os resultados obtidos demonstram o potencial do JcTI para aplicaÃÃo biotecnolÃgica como uma nova proteÃna de defesa contra fungos fitopatogÃnicos e bactÃrias patogÃnicas ao homem.
The residue (cake) obtained after the extraction of oil from jatropha (Jatropha curcas) seeds for biodiesel production is toxic. Despite of the obstacles related to its use in the animal feed, there are evidences that this residue has great potential for biotechnology applications due to its arsenal of molecules. Thus, the present study aimed to purify and characterize a trypsin inhibitor from jatropha cake, in order to make a better use of this residue. The centesimal composition analysis showed to be the jatropha cake mainly composed of proteins (37.21%), fiber (34.26%) and lipids (19.16%). The crude extract obtained from the jatropha cake under alkaline condition (100 mM sodium borate buffer, pH 10.0) showed the presence of lectin (319.76 HU/gF), papain inhibitor (1,287.38 IU/gF), protease (2.69 AU/gF) and, especially, trypsin inhibitor (1,649.7 IU/gF). The trypsin inhibitor, named JcTI, was purified by fractionation of the crude extract with trichloroacetic acid (2.5%) followed by affinity chromatography (trypsin-sepharose-4B) and molecular exclusion (sephacryl S-200). JcTI is a glycoprotein (6.4% carbohydrates) with molecular mass in the range of 20-21 kDa, pI of 6.6, NH2-terminal sequence (VRDICKKEAERQDLSSCENYITQRRGY) showing identity around 60% with plant albumins and highly stable to heat, pH and salinity. JcTI (500 Âg/mL) slowed the growth of important phytopthogenic fungi, including Colletotrichum gloeosporioides, Colletotrichum lindemuthianum, Fusarium oxysporum and Fusarium solani. This inhibitor also presented antibacterial activity against human pathogenic bacteria such as Bacillus subtilis, Salmonella choleraesuis and Staphylococcus aureus, with minimum inhibitory concentration less than 5 Âg/mL. The results demonstrate the potential of JcTI for biotechnological application as a new defense protein against phytopthogenic fungi and human pathogenic bacteria.
Books on the topic "Antifungal and antibacterial activity"
Sutcliffe, Joyce A., and Nafsika H. Georgopapadakou, eds. Emerging Targets in Antibacterial and Antifungal Chemotherapy. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3274-3.
Full textRay, A. B. Medicinal properties of plants: Antifungal, antibacterial, and antiviral activities. Lucknow: International Book Distributing Co., 2004.
Find full textBōkin Bōbaizai Jiten Shuppan Iinkai, ed. Bōkin bōbaizai jiten. Ōsaka-shi: Nihon Bōkin Bōbai Gakkai, 1986.
Find full textStig, Lindholm. Design, synthesis, and antibacterial activity of some pyridylguanidines. Helsinki: Suomalainen Tiedeakatemia, 1990.
Find full textGifford, Jennifer Ann. Antifungal activity of trihalogenmethylthio compounds in controlled release paints. Birmingham: University of Birmingham, 1994.
Find full textStevens, Paul James Edward. The antibacterial activity of some analogues of nalidixic acid. Uxbridge: Brunel University, 1985.
Find full textGrayson, M. Lindsay. Kucers' the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs : Antibiotics. London: Hodder Arnold, 2010.
Find full textFund, Pacific West Cancer, and National Cancer Coalition, eds. Cecropins: A class of lytic peptides : promising antibacterial and antitumor activity. Seattle, Wash: Distributed by National Cancer Coalition, 1997.
Find full textMcDonald, Claire. Cecropins: A class of lytic peptides : promising antibacterial and antitumor activity. Seattle, Wash: Distributed by National Cancer Coalition, 1997.
Find full textL, Dien Ariani. A bioautographic TLC assay [sic] for the detection of antibacterial activity of some Zingiberaceae in jamu gendong. Surabaya: Pusat Penelitian Obat Tradisional, Universitas Katolik Widya Mandala, 1997.
Find full textBook chapters on the topic "Antifungal and antibacterial activity"
Ryley, John F., and Keith Barrett-Bee. "Screening for Antifungal Activity." In Emerging Targets in Antibacterial and Antifungal Chemotherapy, 546–67. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3274-3_21.
Full textHayhoe, Elisa J., and Enzo A. Palombo. "Screening for Antibacterial, Antifungal, and Anti quorum Sensing Activity." In Methods in Molecular Biology, 219–25. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-577-4_16.
Full textStefanović, Olgica. "Antibacterial and Antifungal Activity of Secondary Metabolites of Teucrium Species." In Teucrium Species: Biology and Applications, 319–54. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52159-2_12.
Full textBöhme, Karola, Jorge Barros-Velázquez, Pilar Calo-Mata, and Santiago P. Aubourg. "Antibacterial, Antiviral and Antifungal Activity of Essential Oils: Mechanisms and Applications." In Antimicrobial Compounds, 51–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40444-3_3.
Full textChandraprabha, M. N., K. Samrat, and Shah Shraddha. "Assessment of Antibacterial and Antifungal Activity of Zero Valent Iron Nanoparticles." In Nanomaterials, 281–95. Oakville, ON ; Waretown, NJ : Apple Academic Press, [2018]: Apple Academic Press, 2018. http://dx.doi.org/10.1201/b21267-13.
Full textRajeshkumar, S., R. V. Santhiyaa, and P. Veena. "Plant and Its Biomolecules on Synthesis of Silver Nanoparticles for the Antibacterial and Antifungal Activity." In Exploring the Realms of Nature for Nanosynthesis, 109–45. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99570-0_6.
Full textBaron, Florence, and Sophie Réhault. "Compounds with Antibacterial Activity." In Bioactive Egg Compounds, 191–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-37885-3_23.
Full textKirubakari, Balasupramaniam, Shanmugapriya, Thiagarajan Sangeetha, Soundararajan Vijayarathna, Yeng Chen, Jagat R. Kanwar, Chiuan Herng Leow, et al. "Antibacterial and Antifungal Agents of Higher Plants." In Natural Bio-active Compounds, 493–508. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-7154-7_16.
Full textSeo, Hiroshi, Koichi Mitsuhashi, and Hiroaki Tanibe. "Antibacterial and Antifungal Fiber Blended by Chitosan." In Advances in Chitin and Chitosan, 34–40. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-5942-5_5.
Full textHammer, Katherine A., and Christine F. Carson. "Antibacterial and Antifungal Activities of Essential Oils." In Lipids and Essential Oils as Antimicrobial Agents, 255–306. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470976623.ch11.
Full textConference papers on the topic "Antifungal and antibacterial activity"
Michnová, Hana, Šárka Pospíšilová, Ewelina Spaczynska, Wioleta Cieslik, Alois Čížek, Robert Musiol, and Josef Jampílek. "Antibacterial and Antifungal Activity of Styrylquinoline Derivatives." In 4th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05588.
Full textMaglakelidze, Benedikte, Guguli Abashidze, Inga Dadeshidze, Vakxtang Mshvildadze, Andre Pichete, Vincent Perreten, Shota Tsanava, Nata Shubladze, and Koba Gurielidze. "Evaluation of in vitro and in vivo antibacterial and antifungal activity of "Camelyn M"." In Proceedings of the International Conference on Antimicrobial Research (ICAR2010). WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789814354868_0018.
Full textLekhniuk, Nadiia. "COMPARATIVE ASSESSMENT OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF HAND SANITIZERS PRODUCED BEFORE AND DURING COVID-19 PANDEMIC." In TENDENZE ATTUALI DELLA MODERNA RICERCA SCIENTIFICA, chair Yulian Konechnyi. European Scientific Platform, 2020. http://dx.doi.org/10.36074/05.06.2020.v2.48.
Full textAntoci, Vasilichia, Gheorghita Zbancioc, Liliana Oniciuc, Dorina Amariucai-Mantu, Costel Moldoveanu, Ramona Danac, Catalina Ciobanu, Violeta Mangalagiu, and Ionel Mangalagiu. "Benzo[f]quinolinium salts: antibacterial and antifungal activities." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab14.
Full textHardhi, Matthew, Delfina, Putty Ekadewi, Retno Widyati, Yuswan Muharam, Widodo Wahyu Purwanto, Dewi Tristantini, and Misri Gozan. "Conceptual design of antifungal and antibacterial herbal ear hygiene product." In THE 5TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 5th International Symposium of Biomedical Engineering (ISBE) 2020. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0047190.
Full textGuo, Zhanyong, Ronge Xing, Huahua Yu, Song Liu, and Pengcheng Li. "Antifungal Activity of Quaternized Carboxymethyl Chitosan." In 2008 2nd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2008. http://dx.doi.org/10.1109/icbbe.2008.305.
Full textSubaer, Abdul Haris, Nurfadilla, Nur Syamsih Amalia, and Nur Akifah. "The prospect of geopolymers-Cu nanoparticles as antibacterial and antifungal composites." In GREEN DESIGN AND MANUFACTURE: ADVANCED AND EMERGING APPLICATIONS: Proceedings of the 4th International Conference on Green Design and Manufacture 2018. Author(s), 2018. http://dx.doi.org/10.1063/1.5066814.
Full textJumate, E., C. Aciu, D. L. Manea, D. Moldovan, R. Chelcea, and R. Fechete. "Plastering mortar with antibacterial and antifungal properties studied by 1H NMR relaxometry." In 11TH INTERNATIONAL CONFERENCE OF PROCESSES IN ISOTOPES AND MOLECULES (PIM 2017). Author(s), 2017. http://dx.doi.org/10.1063/1.5018289.
Full textAlves, Luis, João Portel, Sílvia Sousa, Jorge Leitão, and Ana Martins. "Antibacterial activity of cyclam derivatives." In 4th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05595.
Full textDybowska-Sarapuk, Ł., A. Kotela, J. Krzemiński, D. Janczak, M. Wróblewska, H. Marchel, P. Łęgorz, and M. Jakubowska. "Antibacterial activity of graphene layers." In Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2016, edited by Ryszard S. Romaniuk. SPIE, 2016. http://dx.doi.org/10.1117/12.2249188.
Full textReports on the topic "Antifungal and antibacterial activity"
Sikes, A., T. Yang, M. Richardson, and R. Ehioba. Antifungal Activity of Volatile Oil of Mustard (VOM). Fort Belvoir, VA: Defense Technical Information Center, March 2005. http://dx.doi.org/10.21236/ada430743.
Full textNemska, Veronica, Nelly Georgieva, Jeny Miteva-Staleva, Ekaterina Krumova, and Svetla Danova. Antifungal Activity of Lactobacillus spp. from Traditional Bulgarian Dairy Products. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2019. http://dx.doi.org/10.7546/crabs.2019.12.10.
Full textRocky, AMK Bahrum Prang, and Amanda J. Thompson. Production of Ecofriendly Natural Bamboo Bast Fiber and Assessment of Antibacterial Activity. Ames: Iowa State University, Digital Repository, 2017. http://dx.doi.org/10.31274/itaa_proceedings-180814-277.
Full textKo, Kyung Yuk, Aubrey F. Mendonca, and Dong U. Ahn. Influence of Zn2 + , Sodium Bicarbonate, and Citric Acid on the Antibacterial Activity of Ovotransferrin against E. coli O157:H7 and L. monocytogenes in Model Systems and Ham. Ames (Iowa): Iowa State University, January 2010. http://dx.doi.org/10.31274/ans_air-180814-1020.
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