Journal articles: 'Antifungal and antibacterial activity'

1

Khan, M. R., and A. D. Omoloso. "Antibacterial, antifungal activity of Harpullia petiolaris." Fitoterapia 73, no. 4 (July 2002): 331–35. http://dx.doi.org/10.1016/s0367-326x(02)00077-1.

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Majiene, D., S. Trumbeckaite, A. Pavilonis, A. Savickas, and D. Martirosyan. "Antifungal and Antibacterial Activity of Propolis." Current Nutrition & Food Science 3, no. 4 (November 1, 2007): 304–8. http://dx.doi.org/10.2174/1573401310703040304.

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Annenkova, V. Z., M. G. Voronkov, and V. M. Annenkova. "Antibacterial and antifungal activity of feracryl." Pharmaceutical Chemistry Journal 31, no. 3 (March 1997): 145–46. http://dx.doi.org/10.1007/bf02464668.

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Panneerselvam, P., and G. Geete Ganesh. "Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives." E-Journal of Chemistry 8, s1 (2011): S149—S154. http://dx.doi.org/10.1155/2011/905643.

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The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR,1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activityi.e. antibacterial activity againstS. aureusandE. coliand antifungal activity against fungusA. nigar. CompoundsG5andG7exhibited significant both antibacterial and antifungal activity whileG2,G10andG3,G9showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.

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Huang, Han-Fen, and Chien-Fang Peng. "Antibacterial and antifungal activity of alkylsulfonated chitosan." Biomarkers and Genomic Medicine 7, no. 2 (June 2015): 83–86. http://dx.doi.org/10.1016/j.bgm.2014.09.001.

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Wilkinson, Jenny M., Michael Hipwell, Tracey Ryan, and Heather M. A. Cavanagh. "Bioactivity ofBackhousia citriodora: Antibacterial and Antifungal Activity." Journal of Agricultural and Food Chemistry 51, no. 1 (January 2003): 76–81. http://dx.doi.org/10.1021/jf0258003.

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Liu, H., X. L. Yang, J. Y. Ding, Y. D. Feng, and H. B. Xu. "Antibacterial and antifungal activity of Erigeron breviscapus." Fitoterapia 74, no. 4 (June 2003): 387–89. http://dx.doi.org/10.1016/s0367-326x(03)00068-6.

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El Amraoui, B., M. El Amraoui, N. Cohen, and A. Fassouane. "Antifungal and antibacterial activity of marine microorganisms." Annales Pharmaceutiques Françaises 72, no. 2 (March 2014): 107–11. http://dx.doi.org/10.1016/j.pharma.2013.12.001.

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Erdemoglu, Nurgün, Gökalp Iscan, Bilge Sener, and Prasit Palittapongarnpim. "Antibacterial, antifungal, and antimycobacterial activity ofIlex aquifoliumleaves." Pharmaceutical Biology 47, no. 8 (June 12, 2009): 697–700. http://dx.doi.org/10.1080/13880200902930431.

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Haruna, Muyideen. "Antibacterial and Antifungal Activity of Acalypha wilkesiana." European Journal of Medicinal Plants 3, no. 1 (January 10, 2013): 52–64. http://dx.doi.org/10.9734/ejmp/2013/2220.

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Ijaz, T., F. A. Ranjha, M. K. Shahzad, M. A. Khan, M. Imran, N. Ijaz, and S. Ijaz. "Antibacterial and Antifungal Activity of Different Honeys." International Journal of Infectious Diseases 12 (December 2008): e403. http://dx.doi.org/10.1016/j.ijid.2008.05.1061.

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Karpiński, Tomasz M. "Marine Macrolides with Antibacterial and/or Antifungal Activity." Marine Drugs 17, no. 4 (April 23, 2019): 241. http://dx.doi.org/10.3390/md17040241.

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Currently, the increasing resistance of microorganisms to antibiotics is a serious problem. Marine organisms are the source of thousands of substances, which also have antibacterial and antifungal effects. Among them, marine macrolides are significant. In this review, the antibacterial and/or antifungal activities of 34 groups of marine macrolides are presented. Exemplary groups are chalcomycins, curvulides, halichondramides, lobophorins, macrolactins, modiolides, scytophycins, spongistatins, or zearalanones. In the paper, 74 antibiotics or their analog sets, among which 29 with antifungal activity, 25 that are antibacterial, and 20 that are both antifungal and antibacterial are summarized. Also, 36 macrolides or their sets are produced by bacteria, 18 by fungi, ten by sponges, seven by algae, two by porifera, and one by nudibranch. Moreover, the chemical structures of representatives from each of the 34 groups of these antibiotics are presented. To summarize, marine organisms are rich in natural macrolides. Some of these may be used in the future in the treatment of bacterial and fungal infections. Marine macrolides can also be potential drugs applicable against pathogens resistant to currently known antibiotics.

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Neghra, Abdelhak, Marylin Lecsö, Marie-José Butel, Laila S. Espindola, Brigitte Deguin, and Elisabeth Seguin. "Amidochromenes for Promising Antileishmanial Activity." Natural Product Communications 12, no. 9 (September 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200919.

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Numerous natural products having a 2,2-dimethylchromene (2,2-dimethylbenzopyrane) structural element present interesting biological activities that may, therefore, be considered as privileged pharmacophore. Nine aliphatic and aromatic amides were synthesized from the 5-amino-7-methoxy-2,2-dimethyl-2 H-chromene synthon. The antibacterial, antifungal, antileishmanial and cytotoxic activities of all amidochromenes were evaluated. No antibacterial or antifungal activity was observed. Nevertheless, three aromatic amides compounds shown significant antileishmanial activity with an excellent selectivity index.

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Bozinovic, Nina, Irena Novakovic, Sladjana Kostic-Rajacic, Igor Opsenica, and Bogdan Solaja. "Synthesis and antimicrobial activity of azepine and thiepine derivatives." Journal of the Serbian Chemical Society 80, no. 7 (2015): 839–52. http://dx.doi.org/10.2298/jsc150116013b.

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A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.

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Ajdacic, Vladimir, Jelena Lazic, Marija Mojicevic, Sandra Segan, Jasmina Nikodinovic-Runic, and Igor Opsenica. "Antibacterial and antifungal properties of guanylhydrazones." Journal of the Serbian Chemical Society 82, no. 6 (2017): 641–49. http://dx.doi.org/10.2298/jsc170213033a.

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A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 ?g mL-1, and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development.

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Terenteva, E., S. Sasmakov, S. Azimov, V. Vinogradova, D. Abdurakhmanov, Z. Khashimova, and A. Saidov. "The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 74, no. 2 (2017): 51–55. http://dx.doi.org/10.17721/1728_2748.2017.74.51-55.

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The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.

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K, Sharath, Krishna Mohan G, Sandhya Rani M, Kowmudi V, Suresh N, and Chintanippula Sai Rama Rao. "Evaluation of Antibacterial and Anti Fungal Activity of Hexane and Methanol Extracts of Psoralea Corylifolea Seed." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 01 (March 1, 2016): 25–30. http://dx.doi.org/10.21477/ijapsr.v1i1.9605.

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Objective: To evaluate antibacterial and antifungal activity of hexane and methanol extracts of Psoralea Corylifolea Seed. Method: Psoralea Corylifolia seeds were extracted by using different solvents hexane and methanol and the test extracts were assayed for antibacterial and antifungal activity. The antibacterial activity was tested against Staphylococcus aureus and antifungal activity was tested against Candida albicans and Aspergillus niger by agar well diffusion method and measuring the zone of Inhibition. Results: The hexane and methanol extracts of Psoralea corylifolia seed was very effective against Staphylococcus aureus, Candida albicans and Aspergillus niger. The results showed unique characters of the plant in inhibiting bacterial and fungal growth. Conclusion: In the present study antibacterial and anti fungal activity of hexane and methanol extracts of psoralea corylifolea seed was confirmed.

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Ermenlieva, Neli, Emilia Georgieva, and Minko Milev. "ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF ANTIPERSPIRANT COSMETIC PRODUCTS." Journal of IMAB - Annual Proceeding (Scientific Papers) 26, no. 4 (October 7, 2020): 3374–77. http://dx.doi.org/10.5272/jimab.2020264.3374.

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Goun, E., G. Cunningham, D. Chu, C. Nguyen, and D. Miles. "Antibacterial and antifungal activity of Indonesian ethnomedical plants." Fitoterapia 74, no. 6 (September 2003): 592–96. http://dx.doi.org/10.1016/s0367-326x(03)00117-5.

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Seibert, Gerhard, Wolfgang Raether, Nikola Dogović, Miroslav J. Gasić, Rudolf K. Zahn, and Werner E. G. Müller. "Antibacterial and Antifungal Activity of Avarone and Avarol." Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology 260, no. 3 (November 1985): 379–86. http://dx.doi.org/10.1016/s0176-6724(85)80026-2.

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Tonea, Andrada, Mandra Badea, Liviu Oana, Sorina Sava, and Dan Vodnar. "Antibacterial and antifungal activity of endodontic intracanal medications." Medicine and Pharmacy Reports 90, no. 3 (July 25, 2017): 344–47. http://dx.doi.org/10.15386/cjmed-750.

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Background and aims. The sterilization of the entire root canal system represents the main goal of every endodontist, given the fact that the control of the microbial flora is the key point of every root canal treatment. The diversity of microorganisms found inside the root canal and also the resistance of some bacterial species to intracanal medications led to a continuous development of new endodontic products. The present study focuses on the comparison of the antibacterial and antifungal properties of different endodontic products, two commercially available, one experimental plant based extract, and two control substances.Methods. The disc diffusion assay was used to determine the antibacterial and antifungal properties of chlorhexidine, calcium hydroxide, a mix extract between Arctium lappa root powder and Aloe barbadensis Miller gel, Amoxicillin with clavulanic acid and Fluconazole (as control substances). Two of the most common microorganisms found in endodontic infections were chosen: Enterococcus faecalis (ATCC 29212) and Candida albicans ATCC(10231).Results. All tested substances showed inhibition zones around the discs, for Enterococcus faecalis and Candida albicans, including the experimental mix extract of Arctium lappa root powder with Aloe vera gel.Conclusion. The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms, like Enterococcus faecalis and Candida albicans.

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Esteban-Tejeda, Leticia, Catuxa Prado, Belén Cabal, Jesús Sanz, Ramón Torrecillas, and José Serafín Moya. "Antibacterial and Antifungal Activity of ZnO Containing Glasses." PLOS ONE 10, no. 7 (July 31, 2015): e0132709. http://dx.doi.org/10.1371/journal.pone.0132709.

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Chandrasekaran, M., and V. Venkatesalu. "Antibacterial and antifungal activity of Syzygium jambolanum seeds." Journal of Ethnopharmacology 91, no. 1 (March 2004): 105–8. http://dx.doi.org/10.1016/j.jep.2003.12.012.

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Shalini, Kumari, Nitin Kumar, Sushma Drabu, and Pramod Kumar Sharma. "Advances in synthetic approach to and antifungal activity of triazoles." Beilstein Journal of Organic Chemistry 7 (May 25, 2011): 668–77. http://dx.doi.org/10.3762/bjoc.7.79.

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Several five membered ring systems, e.g., triazole, oxadiazole dithiazole and thiadiazole with three heteroatoms at symmetrical or asymmetrical positions have been studied because of their interesting pharmacological properties. In this article our emphasis is on synthetic development and pharmacological activity of the triazole moiety which exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these infections even with antifungal therapy is still unacceptably high. Therefore, the development of new antifungal agents targeting specific fungal structures or functions is being actively pursued. Rapid developments in molecular mycology have led to a concentrated search for more target antifungals. Although we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded.

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Taufikurohmah, Titik, and Tasha Anandya Tantyani. "ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SILVER NANOPARTICLES AGAINST NEISSERIA GONORRHOEAE AND CANDIDA ALBICANS." International Journal of Research -GRANTHAALAYAH 8, no. 6 (July 9, 2020): 179–87. http://dx.doi.org/10.29121/granthaalayah.v8.i6.2020.461.

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This Research on the antibacterial and antifungal activity of nanosilver against Neisseria gonorrhoeae and Candida albincas fungi has been carried out. The purpose of this study was to determine antibacterial activity of nanosilver against Neisseria gonorrhoeae and antifungal activity against Candida albincas. Synthesis Nanosilver uses bottom up method and characterized using UV-Vis Spectrophotometer. Nanosliver concentrations used were 30, 40, 50, and 60 ppm. Antibacterial and antifungal activity tests using disk diffusion method. Observations obtained in form of the presence or absence of clear zones formed around paper discs indicate the inhibition of nanosilver on microbial growth. The results of testing the antifungal activity of Candida albicans on nanosilver with concentrations of 30, 40, 50 and 60 ppm resulted in clear zones of 9.73 nm, 11.46 nm, 11.93 nm, and 13 nm with fungal inhibition response categories is medium and strong. The results antibacterial activity test of Neisseria gonorrhoeae on nanosilver with concentrations of 30, 40, 50 and 60 ppm did not show any clear zone around the disc, it showed that nanosilver in this study did not have antibacterial activity against Neisseria gonorrhoeae.

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Shah, Nirav, Nimesh Shah, Manish Patel, and Ranjan Patel. "Design, synthesis and antimicrobial activity of new biquinoline derivatives." Journal of the Serbian Chemical Society 77, no. 3 (2012): 279–86. http://dx.doi.org/10.2298/jsc110630197s.

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A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and ?-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.

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Kiran, Ismail, Semra Ilhan, Tamer Akar, Lacine Tur, and Erdinc Erol. "Synthesis and Evaluation of Demethoxyviridin Derivatives as Potential Antimicrobials." Zeitschrift für Naturforschung C 60, no. 9-10 (October 1, 2005): 686–92. http://dx.doi.org/10.1515/znc-2005-9-1005.

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Abstract The in vitro antibacterial and antifungal activities of demethoxyviridin and some synthetic analogues were evaluated by the agar diffusion method. The minimum inhibitory concentrations (MIC) of the active compounds were also determined by the agar dilution method. Demethoxyviridin (1) showed moderate antibacterial activity against most of the strains tested. 1α-Hydroxydemethoxyviridin (3) showed antibacterial activity and the most potent in vitro antifungal activity with MIC of 20 μg/ml (0.062 mm) against Aspergillus niger, A. fumigatus, A. flavus, A. parasiticus, Fusarium solani, F. graminarum, Geotrichum candidum whereas 5′-methylfuro-(4′,3′,2′-4,5,6)androst-5-ene-3,17-dione (7) exhibited very weak antifungal activity against Candida albicans only.

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Jumina, Mutmainah, Purwono, Kurniawan, and Syah. "Antibacterial and Antifungal Activity of Three Monosaccharide Monomyristate Derivatives." Molecules 24, no. 20 (October 14, 2019): 3692. http://dx.doi.org/10.3390/molecules24203692.

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Microbial infections remains a serious challenge in food industries due to their resistance to some of the well-known antibacterial and antifungal agents. In this work, a novel monomyristoyl ester (fructosyl monomyristate) and two other derivatives (i.e., glucosyl and galactosyl monomyristates) were successfully synthesized from myristic acid and monosaccharides in two-step reactions. First, the myristic acid was converted to myristoyl chloride, and then the myristoyl chloride was reacted with fructose, glucose and galactose separately to produce the corresponding monosaccharide monomyristate derivatives. The structures of the synthesized products were confirmed by Fourier transform infrared (FTIR), proton and carbon nuclear magnetic resonance (1H- and 13C-NMR), and mass spectral (MS) data. The monomyristates esters were obtained in reaction yields of 45.80%–79.49%. The esters were then evaluated for their antimicrobial activity using the disc diffusion test. It was found that the esters exhibited a medium antibacterial activity against gram-positive bacteria; however, they showed a weak antibacterial activity against gram-negative bacteria. Amongst the esters, galactosyl myristate yielded the highest antibacterial activity against Salmonella typhimurium, Staphylococcus aureus and Bacillus subtilis, while glucosyl monomyristate exhibited the highest antibacterial activity only against Escherichia coli. Additionally, all products showed remarkable antifungal activity against Candida albicans. These findings demonstrate that monosaccharide monomyristate derivatives are promising for use as biocompatible antimicrobial agents in the future.

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Lemriss, S., F. Laurent, A. Couble, E. Casoli, J. M. Lancelin, D. Saintpierre-Bonaccio, S. Rifai, A. Fassouane, and P. Boiron. "Screening of nonpolyenic antifungal metabolites produced by clinical isolates of actinomycetes." Canadian Journal of Microbiology 49, no. 11 (November 1, 2003): 669–74. http://dx.doi.org/10.1139/w03-088.

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The purpose of this work was to screen clinical isolates of actinomycetes producing nonpolyenic antifungals. This choice was made to limit the problem of rediscovery of well-known antifungal families, especially polyenic antifungals. One hundred and ten strains were tested, using two diffusion methods and two test media, against three yeast species and three filamentous fungi. Among 54 strains (49%) showing antifungal activity, five strains belonging to the genus Streptomyces were active against all test organisms and appeared promising. These results indicate that clinical and environmental isolates of actinomycetes could be an interesting source of antifungal bioactive substances. The production of nonpolyenic antifungal substances by these five active isolates was investigated using several criteria: antibacterial activity, ergosterol inhibition, and UV-visible spectra of active extracts. One active strain responded to all three selection criteria and produced potentially nonpolyenic antifungal metabolites. This strain was retained for further investigation, in particular, purification, structure elucidation, and mechanism of action of the active product.Key words: actinomycetes, Streptomyces, clinical isolates, antifungal, non-polyene.

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Šiler, Branislav, Danijela Mišić, Jasmina Nestorović, Tijana Banjanac, Jasmina Glamočlija, Marina Soković, and Ana Ćirić. "Antibacterial and Antifungal Screening of Centaurium Pulchellum Crude Extracts and Main Secoiridoid Compounds." Natural Product Communications 5, no. 10 (October 2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501001.

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The main principles of C. pulchellum (Sw.) Druce, secoiridoid glycosides, have been studied as potent bioactive compounds. Here we scored their content in extracts of ten populations of this species. Antibacterial and antifungal assays of the extracts and pure secoiridoid glycosides were performed against eight bacterial strains and five fungal species. Methanol extracts from both aerial parts and roots exhibited excellent antibacterial (0.05-0.2 mg mL−1) and very good antifungal (0.1-2 mg mL−1) activity. Pure secoiridoid glycosides isolated from these extracts demonstrated very strong antibacterial (0.01-0.04 mg mL−1) and especially antifungal (0.001-0.1 mg mL−1) activity.

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Baldaniya, B. B., and P. K. Patel. "Synthesis, Antibacterial and Antifungal Activities ofsDerivatives." E-Journal of Chemistry 6, no. 3 (2009): 673–80. http://dx.doi.org/10.1155/2009/196309.

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SeveralNʹ-{4-[(3-chloro-4-fluorophenyl) amino]-6-[(-aryl) amino] -1, 3, 5-triazin-2-yl} isonicotinohydrazides (6a-r) andN2-(Aryl)-N4,N6-dipyrimidin-2-yl-1,3,5-triazine-2,4,6-triamines (4a-o) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of -OH, -OCH3, -NO2, -Cl and -Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

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Veljic, M., Ana Ciric, Marina Sokovic, P. Janackovic, and P. D. Marin. "Antibacterial and antifungal activity of the liverwort (Ptilidium pulcherrimum) methanol extract." Archives of Biological Sciences 62, no. 2 (2010): 381–85. http://dx.doi.org/10.2298/abs1002381v.

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The antimicrobial activity of the methanol extract from the liverwort, Ptilidium pulcherrimum was evaluated against five bacterial and six fungal species. In vitro antibacterial activity was assessed by disc diffusion and microdilution methods. The extract showed a stronger effect against tested Gram (+) than Gram (-) bacteria. The antifungal activity of the methanol extract was tested using a microdilution method. The methanol extract showed strong antifungal activity. The best antifungal activity was achieved against Trichoderma viride compared to the synthetic fungicide bifonazol.

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Rabari, Haribhai, Hetal Vankar, and Beenkumar Prajapati. "Synthesis and Antimicrobial Screening of Some Novel 5-Substituted-1,10b-dihydroimidazole[1,2-c]quinazoline Derivatives." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 2 (April 30, 2021): 5406–11. http://dx.doi.org/10.37285/ijpsn.2021.14.2.6.

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The emergence of multidrug microbial resistance is the main challenges that the modern scientists have so far been facing in the recent era. In this respect, new series of drug classes having potential to give antimicrobial effect have been synthesized. A new series of 5- substituted-1,10 b-dihydroimidazole[1,2-c]quinazoline derivatives 8a-e have been synthesized and screened for antibacterial activity and antifungal activity. Synthesized derivatives were characterized by IR, MASS and 1H-NMR spectroscopy. Synthesized compounds show good activity, which was comparable to the standard drug and it can be useful for the further clinical study. Antibacterial activity was evaluated against four different pathogenic bacterial strains like Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudo-monas aeruginosa. Among the screened compounds, 8e show good antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC of 50 and 100 μg/ml respectively. Antifungal activity was evaluated against two strains of fungi. Among the synthesized derivates, compound 8c was emerged out as the potent antifungal compound against Candida albicans and Aspergillus niger with MIC of 25 μg/ml and 75μg/ml respectively. Compound 8e also shows good antifungal activity with MIC of 50 μg/ml against both Candida albicans and Aspergillus niger. The overall results of this study indicated that synthesized quinazoline derivatives had the potential to act as an antibacterial and antifungal agent, hence further investigation is warranted.

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Stanković-Jeremić, Jovana, Miroslav Novaković, Vele Tešević, Ana Ćirić, Gordana Zdunić, Zora Dajić-Stevanović, and Dejan Gođevac. "Antifungal activity of the essential oil from Artemisia santonicum and its constituent isogeranic acid." Lekovite sirovine, no. 40 (2020): 62–65. http://dx.doi.org/10.5937/leksir2040062s.

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This study represents a continuation of exploring of the biological activities of the Artemisia santonicum essential oil. The previous investigation was focused on the antibacterial, antibiofilm, and antiquorum activities of A. santonicum essential oil and isogeranic acid as the main antibacterial constituent. The present study describes its antifungal activity. The antifungal activity of the A. santonicum essential oil was tested against eight fungi isolates, whereas antifungal effects of isogeranic acid were studied using four fungi species, because of the limited quantities of the isolated compound. The results were compared to the commercial antimycotics, bifonazole and ketoconazole. Antifungal activity of isogeranic acid against all tested fungi was significantly higher in comparison to the essential oil and the both controls.

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Roy, R. U., A. R. R. Desai, and K. R. Desai. "Synthesis and Antimicrobial Activity of 1,2,4-Triazoles." E-Journal of Chemistry 2, no. 1 (2005): 1–5. http://dx.doi.org/10.1155/2005/843803.

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Several 3-(4'-nitrophenyl)-4-(4"-chloro benzamido)-5-substituted phenyl)-4H-1,2,4-triazole (3a-3e) and 3-(4'-nitrophenyl)-4-(4"-methyl benzenesulphonamido)-5-substituted phenyl)-4H-1,2,4-triazole (4a-4e) have been synthesised. Representative compounds were screened for antibacterial, antifungal activity. Most of them showed significant antibacterial activity.

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Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (August 30, 2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side chain. Presented information constitute a concise summary, which may be used as a practical guide for further design of new molecules with antimicrobial activity.

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Tapalsky, D. V., D. R. Petrenev, O. M. Khramchenkova, and A. S. Doroshkevich. "ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF LICHENS PREVALENT IN BELARUS." Journal of microbiology epidemiology immunobiology, no. 2 (April 28, 2017): 60–65. http://dx.doi.org/10.36233/0372-9311-2017-2-60-65.

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Aim. Study spectrum and expressiveness of antibacterial and antifungal properties oflichen extracts. Materials and methods. Antimicrobial activity of acetone extracts from Hypogymnia physodes, Xanthoria parietina, Evernia prunastri, Ramalina pollinaria, Cladonia arbuscula lichens was determined by micro-dilution methods in broth for 4 - 500 mcg/ml concentrations against 13 strains from ATCC collection and 6 clinical isolates. Results. High antibacterial activity of H. physodes and C. arbuscular extracts against staphylococci and enterococci was detected (MIC 31 - 62 mcg/ml). Antimicrobial activity against enterobacteria and Pseudomonas aeruginosa was absent for all the extracts. E.prunastri, H.physodes and C arbuscula extracts were active against Stenotrophomonas maltophilia strains (MIC 250 - 500 mcg/ml). Antifungal activity (MIC 500 mcg/ml for 4 Candida strains) was only detected for the E. prunastri extract. Conclusion. H.physodes and C. arbuscula lichens can be examined as a perspective source of antibacterial substances, effective against antibiotics resistant staphylococci, streptococci and S. maltophilia strains.

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ZOMORODIAN, K., S. KHABNADIDEH, L. ZAMANI, K. PAKSHIR, and M. TAJADDOD. "EVALUATION OF ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES." Latin American Applied Research - An international journal 48, no. 2 (March 30, 2018): 125–29. http://dx.doi.org/10.52292/j.laar.2018.270.

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The extensive use of antifungal drugs and their resistance against fungal infections have led to discover new antimicrobial compounds. We previously described synthesis of some new derivatives of 2-methylbenzimidazole (1a-5a) and 5,6dimethylbenzimidazol (1b-5b). Here we evaluated the antimicrobial activities of these compounds against different species of micro organisms including gram positive and gram negative bacteria as well as fungi. Broth micro-dilution method as recommended by clinical and laboratory standard institute (CLSI) was used for this purpose. The results show compounds 2-Methyl-1-(3-methylbenzyl)-1H-benzo [d]imidazole (5a) and 5,6-Dimethyl-1-(3-methyl benzyl)-1H-benzo[d]imidazole (5b) had the best antifungal activity against the examined fungi and gram positive bacteria. Moreover these two compounds inhibited the growth of azole resistant strains. By comparison the relationship between the structures and activities of the tested compounds revealed that the presence of methyl residue in meta position of benzyl group enhance the antifungal activity. Regarding a broad spectrum antifungal activities of some of the tested compounds, they might be a good candidate for further in vivo studies to evaluate their pharmacological activity and toxicity as a novel antifungal agents.

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Petrikaitė, Vilma, Eduardas Tarasevičius, and Alvydas Pavilonis. "Synthesis and Antimicrobial Properties of Naphthylamine Derivatives Having a Thiazolidinone Moiety." Medicina 47, no. 6 (June 28, 2011): 47. http://dx.doi.org/10.3390/medicina47060047.

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Objective. The aim of this study was to evaluate the influence of pharmacophores having naphthylamine and nitro groups on the antimicrobial (antibacterial and antifungal) activity of thiazolidinone derivatives. Materials and Methods. The initial 5-substituted-2-methylmercaptothiazolidin-4-ones were subjected to S-demethylation to yield 2-amino-substituted thiazolidinones. 4-Nitro-1-naphthylamine, nitrofuran aldehydes, and nitrobenzene aldehydes were used as pharmacophoric compounds having amino or aldehyde groups. Antimicrobial (antibacterial and antifungal) activity of the new compounds was tested in vitro against bacterial cultures – Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae – and fungal cultures – Candida albicans, Candida glabrata, Candida krusei, Candida kefyr, Candida tropicalis, and Candida parapsilosis. Results. Microbiological analysis showed that all new thiazolidinone derivatives with nitronaphthylamine substituent possessed antibacterial and antifungal properties. New compounds 2a-b showed similar antibacterial activity in vitro against S. aureus and B. subtilis as aminopenicillins. The lowest antibacterial activity of all newly synthesized compounds was against capsule-forming bacteria K. pneumoniae and against gram-negative bacteria E. coli (minimum inhibitory concentration range, 500–1000 μg/mL). Conclusions. The minimum inhibitory concentration of naphthylamine derivatives varied in the range of 0.4–1000 μg/mL, and activity of some newly synthesized compounds was similar to the activity of aminopenicillins and fluconazole, an antifungal preparation. Based on the results, it is possible to separate the perspective group of potential antimicrobial compounds.

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Kader, Md Abdul, Shumaia Parvin, Md Aktar Uzzaman Chowduri, and Md Ekramul Haque. "Antibacterial, antifungal and insecticidal activities of Ruellia tuberosa (L.) root extract." Journal of Bio-Science 20 (January 18, 2014): 91–97. http://dx.doi.org/10.3329/jbs.v20i0.17720.

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Context: Plants as therapeutics are popularized for thousands of years and people continue to rely on them for health care until now due to their effectiveness, easy availability, low cost and comparatively being devoid of serious toxic effects. Microorganisms such as bacteria, fungi and insects are developing resistance to the current therapies very easily and the currently available antibacterial, antifungal agents and pesticides are very much costly and toxic. So the current shift to the use of herbal antibacterial, antifungal agents and pesticides may be more effective, economic and advantageous. Objectives: The present research was performed to investigate the antibacterial, antifungal and insecticidal activities of the methanolic extract of the dried root of the plant Ruellia tuberosa (L.). Materials and Methods: Five Gram (+) ve bacteria namely Staphylococcus aureus, Staphylococcus agalactiae, Bacillus cereus, Bacillus megaterium, Bacillus subtilis; five Gram (-) ve bacteria namely Pseudomonus aeruginosa, Escherichia coli, Shigella flexneri, Shigella dysenteriae, Shigella sonnei were used as test bacteria for testing the antibacterial activity of the plant extract. Antifungal activity was observed against six fungi namely Candida albicans, Aspergillus niger, Aspergillus ochreus, Aspergillus ustus, Rizopus oryzae and Trichophyton rubrum. The disc diffusion assay method was used in both the cases and standard Kanamycin disc (30?g/disc) was used as the reference standard. The test for insecticidal activity was performed by using surface film activity testing method and Tribolium castaneum (Herbst) was used as the test insect. Results: The methanol extract was active against all the bacteria and fungi tested and showed significant antibacterial and antifungal properties with the zone of inhibition 9 to 23 mm for antibacterial screening and 8 to 15 mm for antifungal screening. The insecticidal assay by surface film activity test also revealed strong insecticidal activity with 80% mortality rate of Tribolium castaneum (Herbst) at a dose of 50 mg/ml in 48 hours. Conclusion: From our experiment it is informed that Ruellia tuberosa (L.) may be used to treat bacterial and fungal diseases and also as insect repellant and it is also possible to isolate antibacterial, antifungal and insecticidal drug from this plant. DOI: http://dx.doi.org/10.3329/jbs.v20i0.17720 J. bio-sci. 20: 91-97, 2012

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Kurteva, Vanya B., Svilen P. Simeonov, and Margarita Stoilova-Disheva. "Symmetrical Acyclic Aryl Aldazines with Antibacterial and Antifungal Activity." Pharmacology & Pharmacy 02, no. 01 (2011): 1–9. http://dx.doi.org/10.4236/pp.2011.21001.

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Jelager, Lene, Ameenah Gurib-Fakim, and Anne Adsersen. "Antibacterial and Antifungal Activity of Medicinal Plants of Mauritius." Pharmaceutical Biology 36, no. 3 (January 1998): 153–61. http://dx.doi.org/10.1076/phbi.36.3.153.6345.

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TURHAN, GÜLAY, and F. GROSSMANN. "Antifungal and Antibacterial Activity ofAcrophialophora levisSamson and Tariq Mahmood." Journal of Phytopathology 124, no. 3 (1989): 200–206. http://dx.doi.org/10.1111/j.1439-0434.1989.tb04915.x.

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Kagarlitskii, A. D., L. A. Krichevskii, Z. M. Astaf’eva, S. B. Akhmetova, R. B. Seidakhmetova, and A. I. Drab. "Synthesis and antifungal and antibacterial activity of hexahydronicotine derivatives." Pharmaceutical Chemistry Journal 42, no. 4 (April 2008): 180–82. http://dx.doi.org/10.1007/s11094-008-0098-6.

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Worthington, P. A. "Antibiotics with antifungal and antibacterial activity against plant diseases." Natural Product Reports 5, no. 1 (1988): 47. http://dx.doi.org/10.1039/np9880500047.

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Soltani, N., R. A. Khavari-Nejad, M. Tabatabaei Yazdi, Sh Shokravi, and E. Fernández-Valiente. "Screening of Soil Cyanobacteria for Antifungal and Antibacterial Activity." Pharmaceutical Biology 43, no. 5 (January 2005): 455–59. http://dx.doi.org/10.1080/13880200590963871.

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Akalaeva, T. V., G. A. Bogdanova, A. I. Bokanov, T. A. Gus'kova, E. N. Padeiskaya, T. P. Radkevich, V. I. Shvedov, and L. D. Shipilova. "Pyrazolo[3,4-a]carbazoles: Synthesis, antibacterial and antifungal activity." Pharmaceutical Chemistry Journal 28, no. 8 (August 1994): 566–69. http://dx.doi.org/10.1007/bf02219032.

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Yadav, Bindu Singh, Yeddu Trilochana, Kiran Kumari, Saurabh Singh, and Anupam K. Sachan. "Evaluation of Antibacterial and Antifungal Activity of Moringa Concanensis." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (July 1, 2021): 5566–70. http://dx.doi.org/10.37285/ijpsn.2021.14.4.6.

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In today’s scenario, fungal and bacterial infections are one of the most challenging pestilential diseases for the health-care professional which is increasing with a very high rate in the growing population, especially among the immune compromised people.The present work involved the study to extract active principles of Moringa concanensis and perform antibacterial and antifungal activity for various extracts. The leaves were dried powdered unexpected using solvents petroleum ether, chloroform, ethanol and water. Chemical tests were performed to ascertain presence of various classes of phyto-constituents like alkaloids, glycosides, saponins, carbohydrates, proteins, amino acids tannins, flavonoids and phenolic substances. All four extracts showed the presence of various phytochemicals responsible for multiple pharmacological activities. The extracts were reconstituted using 1% aqueous solution of carboxy methyl cellulose and were tested for antibacterial and antifungal activity against six microorganisms, namely Bacillus subtilis, Enterobacter aerogenes, Bacillus cereus, Aspergillus Flavus, Aspergillus Niger and Helminthosporium, using well diffusion method. The results of the activity are promising with chloroform extract showing highest inhibitory activity against most of the organisms. All the extracts were able to demonstrate significant activity compared to control inhibition of microorganisms tested and hold key to discover lead molecules after further scientific investigation.

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Filho, Antonio Carlos Pereira de Menezes, Matheus Vinícius Abadia Ventura, Carlos Frederico De Souza Castro, Frederico Antonio Loureiro Soares, and Marconi Batista Teixeira. "Antifungal and antibacterial activity of the floral ethanolic extract of Mandevilla pohliana (Stadelm.) A. H. Gentry." Científic@ - Multidisciplinary Journal 8, no. 1 (June 29, 2021): 1–5. http://dx.doi.org/10.37951/2358-260x.2021v8i1.5625.

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Mandevilla pohliana is a species belonging to the Apocynaceae family found in Cerrado environments. The bjetive of this study was to evaluate the antifungal and antibacterial action of the floral ethanolic extract of M. pohliana. Flowers of M. pohliana were collected and the ethanolic extract produced by maceration. In different concentrations of extract, antifungal of the genus Candida were determined, and antibacterial activities on Escherichia, Salmonella, Enterococcus, Pseudomonas and Staphylococcus. Antibiosis activity was observed only for C. guilliermondii with 9-2 mm, for P. aeruginosa with 12-3 mm and for E. faecalis between 10-3 mm at the highest concentrations between 50-500 mg mL-1. The floral ethanolic extract of Mandevilla pohliana showed potential as a natural antifungal and antibacterial agent.

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Bukvicki, Danka, M. Veljic, Marina Sokovic, Slavica Grujic, and P. D. Marin. "Antimicrobial activity of methanol extracts of Abietinella abietina, Neckera crispa, Platyhypnidium riparoides, Cratoneuron filicinum and Campylium protensum mosses." Archives of Biological Sciences 64, no. 3 (2012): 911–16. http://dx.doi.org/10.2298/abs1203911b.

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The antibacterial and antifungal activity of methanol extracts of the genuine mosses Abietinella abietina, Neckera crispa, Platyhypnidium riparoides, Cratoneuron filicinum var. filicinum and Campylium protensum were evaluated. Antibacterial activity was tested against Gram (+) Staphylococcus aureus, Micrococcus flavus, Bacillus cereus and Gram (-) bacteria Escherichia coli and Salmonella typhimurium. Antifungal activity was tested using micromycetes Trichoderma viride, Penicillium funiculosum, Penicillium ochrochloron, Aspergillus flavus, A. niger and A. fumigatus. The methanol extracts of all moss species showed an antimicrobial effect against the tested microorganisms. Significant antibacterial effect was achieved for Cratoneuron filicinum and Neckera crispa. The most sensitive bacteria were Bacillus subtilis and Micrococcus flavus. Abietinella abietina and Neckera crispa showed an antifungal effect against micromycetes Trichoderma viride, Penicillium ochrachloron, P. funiculosum and Aspergillus flavus.

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Journal articles on the topic 'Antifungal and antibacterial activity'

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