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Dissertations / Theses on the topic 'Antifungal antibiotic'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Chan, Tsui Fen. "Studies towards the total synthesis of ambruticin." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244865.

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2

Nedal, Aina. "Post-PKS modifications in the biosynthesis of the antifungal antibiotic nystatin." Doctoral thesis, Norwegian University of Science and Technology, Department of Biotechnology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1581.

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<p>The antifungal polyene macrolide nystatin is produced by <i>Streptomyces noursei</i> ATCC 11455. The nystatin biosynthesis gene cluster of <i>Streptomyces noursei</i> has been cloned and sequenced, and a biosynthesis route has been predicted. In the present work, investigation of genes presumably involved in post-PKS modifications of nystatin is described. The aim of this work was to better understand the nystatin biosynthesis and to further use this information for generation of novel nystatin analogues. Two PKS-modifications of the nystatin molecule were targeted in this study: glycosylat

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3

Beatty, Perrin. "Investigations of an antifungal antibiotic produced by an environmental isolate of Paenibacillus polymyxa." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0014/NQ59930.pdf.

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4

Suloff, Eric Charles. "Comparative Study of Semisynthetic Derivative of Natamycin and the Parent Antibiotic on the Spoilage of Shredded Cheddar Cheese." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/35937.

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The polyene macrolide antibiotic natamycin (Antibiotic A-5283) is commonly used to retard the growth of surface molds on various cheese varieties. Natamycin is commonly applied to the surface of cheese by dipping or spraying, using an aqueous dispersion containing 200 to 300 ppm of the additive. The large molecular weight of natamycin, 666 g/mol, and conjugated double bond structure causes it to be extremely insoluble in water and most food grade solvents. The inability to apply natamycin in true solution creates void non-treated areas on the food surface. These non-treated areas promote t

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5

Pereira, Marie Antoinette Tanya. "Cellular differentiation and antibiotic production by Streptomyces nodosus immobilised in alginate capsules." View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/20504.

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Thesis (PhD) -- University of Western Sydney, 2007.<br>A thesis submitted to the University of Western Sydney, College of Health and Science, School of Natural Sciences, as a requirement for the degree of Doctor of Philosophy. Includes bibliography.

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6

Heldreth, Bart Allan. "N-Thiolated β-Lactams: Chemistry, SAR and Intracellular Target of a Novel Class of Antimicrobial and Anticancer Agents". Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1074.

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N-Thiolated β-lactams (1) represent a promising new group of compounds with potent inhibition effects on bacteria, like Bacillus anthracis and methicillin resistant Staphylococcus aureus, and onco-systems, like breast cancer and leukemia. Originally developed as part of a synthetic pathway to bicyclic lactams, N-thiolated β-lactams have been shown in this laboratory to possess intriguing biological activities. The antibacterial activities of this new class of agents rely on novel structural features unlike those of any existing family of β-lactam drugs. The lactams seem to exert their effects

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7

Pohanka, Anton. "Antifungal antibiotics from potential biocontrol microorganisms /." Uppsala : Department of Chemistry, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200647.pdf.

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8

Sekole, M. J. "The Use of antibiotics post- tonsillectomy at Dr George Mukhari Hospital (DGMH): Is it of benefit ?" Thesis, University of Limpopo (Medunsa Campus), 2011. http://hdl.handle.net/10386/666.

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Thesis (M Med (Otorhinolaryngology))-- University of Limpopo, 2011.<br>Aims: The purpose of this study was to assess if the use of post-operative antibiotics have any beneficial effects in reducing morbidity following elective tonsillectomy in children with age range of 1-13 years. . Objectives: To assess the degree of post-tonsillectomy pain, determine the incidence of secondary haemorrhage, establish the time period to the resumption of a normal diet, document adverse effects of the use of antibiotics (e.g. skin rash, anaphylaxis, diarrhoea and vomiting), determ

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9

Shallow, David A. "Peptide transport in Candida albicans and synthetic antifungal agents." Thesis, Durham University, 1986. http://etheses.dur.ac.uk/6890/.

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These studies have characterized the peptide transport systems of Candida albicans, with a view to the rational design of peptide antifungal agents exploiting the 'smugglin' concept. In initial studies, a series of polyoxin complexes (peptide-nucleoside antibiotics) and individual components, were isolated from a batch of agricultural fungicide (Polyoxin Z). Isolated fractions were toxic to a particulate chitin synthetase preparation from Candida albicans. Different strains of Candida albicans exhibited varied sensitivities to a series of peptide analogues. From a sensitive strain, B2630, spon

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10

Daoud, N. N. "Isolation and characterization of antifungal antibiotics synthesized by Myxococcus spp." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376848.

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11

Martin, Bruce John. "A total synthesis of myxothiazol." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283643.

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12

Vahidi, Hossein. "Isolation and production of bioactive compounds from basidiomycetes." Thesis, University of Strathclyde, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249826.

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13

Shakery, Javad. "The isolation and characterisation of antibiotics and exo-enzymes from strains of Trichoderma harzianum." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366021.

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14

Nzwange, Kivinduka. "Contribution à l'étude de l'action du cycloheximide sur rhodotorula glutinis CBS 3044 et incidence sur la structure de ses hétéropolyosides parietaux." Nancy 1, 1989. http://www.theses.fr/1989NAN10075.

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Le cycloheximide ou actidione, antibiotique antifongique polyvalent, est non bactéricide. La CMI sur une levure sensible, saccharomyces uvarum, a été déterminée. Les études réalisées sur la structure pariétale de rhodotorula glutinis CBS 3044 incubée en présence ou en absence du cycloheximide ont révélé l'existence du fucose, du galactose, du glucose et du mannose. Deux types de peptidohétéromannannes ont été constatés dans les parois RH. Glutinis CBS 3044 : le type alpha, de MMA élevée, pauvre en aminoacides, mais riche en galactose, le type beta, de MMA plus faible, riche en aminoacides mais

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15

Harnois, Isabelle. "Determination du mode d'action d'un lipopeptide antifongique : l'iturine a, proprietes amphiphiles et interactions avec les membranes." Orléans, 1988. http://www.theses.fr/1988ORLE2006.

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16

Harris, Mark R. "Effects of cationic antimicrobial peptides on Candida and Saccharomyces species." Thesis, St Andrews, 2010. http://hdl.handle.net/10023/881.

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17

Shrestha, Jaya P. "Synthesis, Structure-Activity Relationship Study, and Mode of Action Study of 1,4-Naphthoquinone Based Anticancer and Antimicrobial Agents." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4925.

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Synthesizing bioactive small molecules by structural modification of 1,4-naphthoquinone was the primary goal of this research. Several bioactive compounds with anticancer, antifungal, and antibacterial activities were synthesized. All the synthetic protocols were optimized in such ways that do not require cumbersome purification. First, a new protocol for the synthesis of NQM111 was developed. NQM111 is a highly potent anticancer agent developed in our laboratory, but the old protocol does not provide enough quantity for in vivo study. Therefore, a new safe and improved method was developed wh

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18

Paul, Terry R. "Influence of iron deprivation and sub-inhibitory concentrations of antifungal antibiotics on surface antigens of candida albicans yeast cells." Thesis, Aston University, 1988. http://publications.aston.ac.uk/12520/.

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This study examined the effect of iron deprivation and sub-inhibitory concentrations of antifungal agents on yeast cell surface antigen recognition by antibodies from patients with Candida infections. Separation of cell wall surface proteins by sodium dodecyl-polyacrylamide gel electrophoresis (SDS-PAGE) and immunological detection by immunoblotting, revealed that antigenic profiles of yeasts were profoundly influenced by the growth environment. Cells grown under iron-depleted conditions expressed several iron-regulated proteins that were recognized by antibodies from patient sera. An attempt

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19

Govender, Thashlin. "Antifungal activity of epithelia from selected frogs species of the south Western Cape of South Africa." Thesis, Cape Peninsula University of Technology, 2008. http://hdl.handle.net/20.500.11838/1476.

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Thesis (MTech Biomedical Technology)) ---Cape Peninsula University of Technology, 2008<br>Resistance to antibiotics has been acknowledged as a major global public health problem. The use of peptides to provide alternatives to combat multi drug resistant organisms is of current relevance to overcome antibiotic resistance. The high deversity of amphibian skin peptides render these animals a potential source for the discovery of novel drugs.

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20

Szponarski, Wojciech. "Etude par dichroisme circulaire et par marquage isotopique des interactions de l'amphotericine b et de ses derives avec les erythrocytes humains et leurs membranes isolees." Paris 6, 1987. http://www.theses.fr/1987PA066636.

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21

Troskie, Anscha Mari. "Tyrocidines, cyclic decapeptides produced by soil bacilli, as potent inhibitors of fungal pathogens." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86162.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The global rise in microbial resistance, ranging from the agricultural industry to the medical sector, has created the urgent need for novel or supplementary antibiotics. Antimicrobial peptides or “nature’s antibiotics” may be the answer to this major problem. In this study a group of antimicrobial peptides, cyclic decapeptides named tyrocidines, produced by the soil bacterium Bacillus aneurinolyticus, was investigated for their antifungal activity, possible mode of antifungal action and potential applications. The study i

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22

Yu, Jiunn-Yann, and 于俊彥. "A Study on Microencapsulation of Antifungal Antibiotic." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/26162148748398807967.

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碩士<br>國立中正大學<br>化學工程研究所<br>84<br>The technology of microencapsulation has developed for several decades. Many industries have been concerned with microencapsulated products. Development of the polymers for microencapsulation classically emphasized the technology to make materials durable and weatherable. During the 1970's a need arose of biodegradable materials for drug, agricultural and environment protection requirements. But the existing biodegradable materials are too expensive for the

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23

Liu, Yun-Feng, and 柳雲峰. "STUDIES OF THE ANTIFUNGAL ANTIBIOTIC PRODUCED BY BACTERIUM AF-714 STRAIN." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/89497608969544548252.

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碩士<br>大同工學院<br>化學工程研究所<br>87<br>A antifungal antibiotic producing bacterium strain AF-714, isolated from out door soil was identified as Gram negative. AF-714 strain produced the antifungal antibiotic extracellularly when incubated in liquid medium with 3% sucrose and 0.5% soybean for 20 hours. The antifungal antibiotic was purified from the crude extract of producing broth by acetone precipitation, Fractogel DMAE-650M column, Charcoal activated filtration, Biogel P-2 column, Charcoal activated column, Sephadex G-15 column and Silica gel 60 PLC. The purified antifungal antibiotic was obtained,

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24

Hsu, Li-Hang, and 徐立航. "The Antibiotic Polymyxin B Exhibits Novel Antifungal Activity against Fusarium Species." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/n7a78b.

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碩士<br>國立臺灣大學<br>植物病理與微生物學研究所<br>105<br>The genus Fusarium comprises many species, including F. oxysporum, F. solani, F. graminearum, and F. verticillioides, and causes severe infections in plants and humans. In clinical settings, Fusarium is the third most frequent mold to cause invasive fungal infections, after Aspergillus and the Mucorales. F. solani and F. oxysporum are the most prevalent Fusarium species to cause clinical disease. However, few effective antifungal drugs are available to treat both human and plant Fusarium infections. The cationic peptide antibiotic polymyxin B (PMB) exhibi

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25

Lin, Tsu-Tai, and 林祖泰. "Screening for The Antifungal Antibiotic and Glycoprotein Intracellular Transport Inhibitor from Actinomycetes." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/21846493975696597194.

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博士<br>國立陽明大學<br>生物化學研究所<br>88<br>The aims of this study are to screen the novel antifungal antibiotic and glycoprotein intracellular transport inhibitor. It divied into three parts: 1, the screening for the strains of Actinomycetes, 2, the screening for novel antifungal antibiotics, and 3, screening for the glycoprotein intracellular transport inhibitor. In this study, we collected 85 soil samples from Taiwan island and 188 feces samples from Taipei City Zoo. After using 5 soil pretreatment including dry heat treatment, moisture heat treatment, SDS-yeast treatment and phenol treatme

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26

Pereira, Tanya, University of Western Sydney, College of Health and Science, and School of Natural Sciences. "Cellular differentiation and antibiotic production by Streptomyces nodosus immobilised in alginate capsules." 2007. http://handle.uws.edu.au:8081/1959.7/20504.

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Encapsulation is a novel technique that involves the entrapment of materials such as cells, enzymes or chemicals within a semi-permeable matrix and is being explored as a drug delivery system. This project investigated the encapsulation of Streptomyces nodosus in alginate to assess whether this organism can produce the antifungal drug amphotericin B from within the matrix. New methods were developed to immobilise S. nodosus mycelia and spores in alginate capsules, assess bacterial viability and detect ng mL–1 quantities of amphotericin B in culture fluids. When capsules were cultured and cell

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27

Lin, Tzu-Wen, and 林子文. "Screening of Antifungal Antibiotics from Actinomycetes." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/73823993274424599340.

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碩士<br>國立陽明大學<br>生物化學研究所<br>87<br>Fungicides are often used to control fungal diseases for plant protection in agriculture. Because of the increasing arise of drug resistant fungi and most of the fungicides are not biodegradable that causes residual toxicity to other organism. The development of new antifungal agents that possess low toxicity, high efficacy, and high selectivity is necessary. In this study, methods for the isolation of bacterial strains from animal feces is evaluated. From a collection of 10 different animal feces, a total of 459 Actonimycetes strains were isolated.

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28

Degenhardt, Falko. "Modellsynthesen und Strukturaufklärung von Polyketiden sowie Arbeiten zur Biosynthese von Mimosin." Doctoral thesis, 2000. http://hdl.handle.net/11858/00-1735-0000-0006-B0E2-A.

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29

(6616715), Kwaku Kyei-Baffour. "DEVELOPMENT OF ARYL ISONITRILES AS ANTIMICROBIAL AGENTS, AND TOTAL SYNTHESIS OF 17-NOR-EXCELSINIDINE." Thesis, 2019.

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<p> </p> <p>Infectious diseases caused by bacteria, fungi, and plasmodium parasites are a huge global health problem which ultimately leads to millions of deaths annually. The emergence of strains that exhibit resistance to nearly every class of antimicrobial agents, and the inability to keep up with these resistance trends has brought to the fore the need for new therapeutic agents (antibacterial, antifungal, and antimalarial) with novel scaffolds and functionalities capable of targeting microbial resistance. A novel class of compounds featuring an aryl isonitrile moiety has been discovered

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