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1

St, Georgiev Vassil, New York Academy of Sciences., and International Conference on Drug Research in Immunologic and Infectious Diseases (1st : 1987 : Garden City, N.Y.), eds. Antifungal drugs. New York Academy of Sciences, 1988.

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2

Krysan, Damian J., and W. Scott Moye-Rowley, eds. Antifungal Drug Resistance. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3155-3.

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3

Fernandes, Prabhavathi B., ed. New Approaches for Antifungal Drugs. Birkhäuser Boston, 1992. http://dx.doi.org/10.1007/978-1-4899-6729-9.

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4

B, Fernandes P., ed. New approaches for antifungal drugs. Birkhäuser, 1992.

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5

Manzoor, Nikhat, ed. Advances in Antifungal Drug Development. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-5165-5.

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6

1934-, Yamaguchi Hideyo, Kobayashi George S. 1927-, Takahashi Hisashi 1929-, and International Conference on Antifungal Chemotherapy (1st : 1990 : Oiso-machi, Japan), eds. Recent progress in antifungal chemotherapy. Dekker, 1992.

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7

1923-, Jacobs Paul H., and Nall Lexie 1932-, eds. Antifungal drug therapy: A complete guide for the practitioner. M. Dekker, 1990.

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8

J, Ernst Erika, and Rogers P. David, eds. Antifungal agents: Methods and protocols. Humana Press, 2005.

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9

International, Telesymposium on Recent Trends in the Discovery Development and Evaluation of Antifungal Agents (1987). Recent trends in the discovery, development and evaluation of antifungal agents: Proceedings of an international telesymposium, May 1987. J.R. Prous Science, 1987.

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10

Hall, Gerri S. Interactions of yeasts, moulds, and antifungal agents: How to detect resistance. Humana Press, 2012.

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11

Willard, Rippon John, and Fromtling Robert A. 1953-, eds. Cutaneous antifungal agents: Selected compounds in clinical practice and development. M. Dekker, 1993.

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12

A, Kucers, ed. The use of antibiotics: A clinical review of antibacterial, antifungal, and antiviral drugs. 5th ed. Butterworth-Heinemann, 1997.

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13

Grayson, M. Lindsay. Kucers' the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs : Antibiotics. Hodder Arnold, 2010.

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14

D, Sobel Jack, and Wayne State University. School of Medicine., eds. Clinical perspectives: Terconazole, an advance in vulvovaginal candidiasis therapy : proceedings from a symposium, Laguna Niguel, California, October 15-16, 1987. BMI/McGraw-Hill, 1988.

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15

Claire, Murphy, Cain William S. 1941-, Hegsted D. Mark 1914, and Conference Nutrition and the Chemical Senses in Aging: Recent Advances and Current Research Needs (1988 : Sarasota, Fla.), eds. Nutrition and the chemical senses in aging: Recent advances and current research needs. New York Academy of Sciences, 1989.

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16

Duff, W. Patrick. Antibiotic use in obstetrics and gynecology. W.B. Saunders Co., 1992.

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17

MacCallum, Donna M. Antifungal agents. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0046.

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Although invasive fungal infections lead to significant morbidity and mortality, there remain limited numbers of antifungal drugs available to treat these infections. This chapter describes and discusses the therapeutic antifungal agent classes currently available clinically to treat invasive fungal infections. These include the polyenes, azoles, echinocandins, and flucytosine (5-fluorocytosine). For each drug class, those currently used clinically are listed and their modes of action described. The effectiveness of drugs against different fungal species is explored and any drawbacks to the us
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18

Georgiev, Vassil St. Antifungal Drugs. New York Academy of Sciences, 1988.

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19

Lewis, Russell E. Principles of antifungal therapy. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0045.

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Survival from many life-threatening invasive fungal diseases requires the timely administration of an effective systemic antifungal agent at the correct dose. Although some new antifungal agents have been introduced into clinical practice over the last two decades, each of these antifungals has limitations regarding spectrum, pharmacokinetic/pharmacodynamic properties, toxicity, and cost. Therefore, the selection and dosing of antifungal therapy need to be highly individualized. A growing body of evidence suggests that antifungal therapy is often underdosed, especially in critically ill patien
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20

Ashbee, H. Ruth. Antifungal therapeutic drug monitoring. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0048.

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Therapeutic drug monitoring (TDM), the process of measuring drug concentrations in patients at specified time intervals, aims to ensure that the drug concentrations remain within the efficacious and non-toxic range for that drug. This chapter reviews the rationale for the use of TDM in antifungal therapy, specifically for flucytosine and azoles, including fluconazole, itraconazole, voriconazole, and posaconazole. For each antifungal drug, the bioavailability and excretion of the drug are detailed, as well as specific factors affecting antifungal drug concentrations in patients. The chapter dis
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21

Antifungal and Antiparasitic Drug Delivery. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03936-307-0.

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22

Co, Business Communications. The Market for Antifungal Drugs. Business Communications Company, 2003.

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23

Prabhavathi, B. F. New Approaches for Antifungal Drugs. Birkhäuser Boston, 2014.

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24

FERNANDES and PRABHAVATHI. New Approaches for Antifungal Drugs. Birkhauser Verlag, 2013.

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25

FERNANDES and PRABHAVATHI. New Approaches for Antifungal Drugs. Birkhauser, 2013.

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26

Ghannoum, Mahmoud A., John R. Perfect, and Mahmoud Ghannoum. Antifungal Therapy. Taylor & Francis Group, 2017.

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27

Ernst, Erika J. Antifungal Agents. Humana Press, 2010.

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28

Kim, Jong Heon, Luisa W. Cheng, and Kirkwood Land, eds. Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4767-1.

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29

Krysan, Damian J., and W. Scott Moye-Rowley. Antifungal Drug Resistance: Methods and Protocols. Springer, 2023.

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30

Antifungal drugs: (1,3) [beta]-glucan synthase inhibitors. Springer, 1995.

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31

Shen, Howard. MemoCharts Pharmacology: Antifungal drugs (Review chart) (Paperback). Minireview, 2004.

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32

Seneviratne, Chaminda Jayampath, and Edvaldo Antonio Ribeiro Rosa, eds. Antifungal Drug Discovery: New Theories and New Therapies. Frontiers Media SA, 2016. http://dx.doi.org/10.3389/978-2-88919-950-1.

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33

Advances in Topical Antifungal Therapy. Springer, 1986.

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34

Johnson, Elizabeth M. Antifungal susceptibility testing and resistance. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0047.

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The availability of choice of systemically active antifungal agents and the proliferation in the number of fungal species implicated in invasive disease have meant that clinicians are increasingly looking for guidance from clinical laboratory results to help select the most appropriate agent. There are now well-established and predictable patterns of innate in vitro resistance to one or more antifungal agents associated with many yeast and mould species. This chapter provides definitions for the most frequently used terminology and outlines some of the issues surrounding antifungal susceptibil
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35

Jucker, Ernst. Antifungal Agents: Advances and Problems (Progress in Drug Research). Birkhäuser Basel, 2004.

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36

Ernst, Erika J. Antifungal Agents (Methods in Molecular Medicine). Humana Press, 2005.

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37

Recent Trends in the discovery, development and evaluation of antifungal agents. J.R. Prous Science Publishers, 1987.

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38

Zirngibl, Ludwig. Antifungal Azoles: A Comprehensive Survey of Their Structures and Properties. Wiley & Sons, Incorporated, John, 2020.

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39

Zirngibl, Ludwig. Antifungal Azoles: A Comprehensive Survey of Their Structures and Properties. Wiley-VCH Verlag GmbH, 2005.

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40

Warnock, David W. Introduction to medical mycology. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0001.

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The pattern of fungal diseases has changed with the emergence of new pathogens and the resurgence of old ones. Many factors have contributed to this, including medical progress, environmental changes, and the development of drug resistance. The impact of these diseases on human health is not widely recognized, largely because of the many gaps in epidemiological surveillance data. Access to affordable diagnostics and antifungal drugs are critical issues in the developing world. New approaches to prevention and control will be needed if we are to reduce the substantial global burden of ill healt
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41

Hall, Gerri S. Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance. Humana, 2014.

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42

Hall, Gerri S. Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance. Springer, 2011.

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43

Antifungal Drugs (Annals of the New York Academy of Sciences Vol 544). New York Academy of Sciences, 1991.

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44

Dixon, Chrystal. Itraconazole: An Active Antifungal Drug Used in Treating Infection of the Esophagus. Independently Published, 2019.

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45

Abu-Elteen, Khalid Hussein Ahmad. Effect of sub-inhibitory concentrations of antifungal drugs on adherence of Candida species. 1991.

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46

Kucers, A., S. M. Crowe, M. L. Grayson, and J. F. Hoy. The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs. 5th ed. A Hodder Arnold Publication, 1997.

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47

Combating Fungal Infections Problems And Remedy. Springer, 2010.

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48

Harrison, Mark. Infections. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0042.

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This chapter describes the pharmacology of infections as they apply to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter lists notifiable diseases and outlines the key details of antibacterial drugs, penicillins, cephalosporins tetracyclines, aminoglycosides, macrolides, the management of tuberculosis, quinolones, urinary tract infections, antifungal preparations, herpes virus infections, and antimalarials. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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49

Hube, Bernhard, and Oliver Kurzai. Candida species. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0011.

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Most pathogenic Candida species are members of the microbiota, but also cause superficial or invasive infections. C. albicans is predominant, followed by C. glabrata, C. parapsilosis, and C. tropicalis. C. albicans is polymorphic and grows as yeast, pseudohyphae, or hyphae. The cell wall has multiple functions in pathogenesis. Metabolism and nutrient up-take strategies facilitate growth in multiple niches within the host. Drug resistance is an intrinsic property of C. glabrata and C. krusei, but can be developed by C. albicans and other Candida species during antifungal therapy. Pathogenicity
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50

John, Mills, James McCarthy, Suzanne Crowe, Lindsay M. Grayson, and Alvis Kucers. Kucers' the Use of Antibiotics Sixth Edition: A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs. Taylor & Francis Group, 2014.

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