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1

Fernando, Krishni, Priyanka Reddy, Kathryn M. Guthridge, German C. Spangenberg, and Simone J. Rochfort. "A Metabolomic Study of Epichloë Endophytes for Screening Antifungal Metabolites." Metabolites 12, no. 1 (2022): 37. http://dx.doi.org/10.3390/metabo12010037.

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Epichloë endophytes, fungal endosymbionts of Pooidae grasses, are commonly utilized in forage and turf industries because they produce beneficial metabolites that enhance resistance against environmental stressors such as insect feeding and disease caused by phytopathogen infection. In pastoral agriculture, phytopathogenic diseases impact both pasture quality and animal production. Recently, bioactive endophyte strains have been reported to secrete compounds that significantly inhibit the growth of phytopathogenic fungi in vitro. A screen of previously described Epichloë-produced antifeedant a
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Lemriss, S., F. Laurent, A. Couble, et al. "Screening of nonpolyenic antifungal metabolites produced by clinical isolates of actinomycetes." Canadian Journal of Microbiology 49, no. 11 (2003): 669–74. http://dx.doi.org/10.1139/w03-088.

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The purpose of this work was to screen clinical isolates of actinomycetes producing nonpolyenic antifungals. This choice was made to limit the problem of rediscovery of well-known antifungal families, especially polyenic antifungals. One hundred and ten strains were tested, using two diffusion methods and two test media, against three yeast species and three filamentous fungi. Among 54 strains (49%) showing antifungal activity, five strains belonging to the genus Streptomyces were active against all test organisms and appeared promising. These results indicate that clinical and environmental i
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3

Saxena, Sanjai, Laurent Dufossé, Sunil K. Deshmukh, Hemraj Chhipa, and Manish Kumar Gupta. "Endophytic Fungi: A Treasure Trove of Antifungal Metabolites." Microorganisms 12, no. 9 (2024): 1903. http://dx.doi.org/10.3390/microorganisms12091903.

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Emerging and reemerging fungal infections are very common in nosocomial and non-nosocomial settings in people having poor immunogenic profiles either due to hematopoietic stem cell transplants or are using immunomodulators to treat chronic inflammatory disease or autoimmune disorders, undergoing cancer therapy or suffering from an immune weakening disease like HIV. The refractory behavior of opportunistic fungi has necessitated the discovery of unconventional antifungals. The emergence of black fungus infection during COVID-19 also triggered the antifungal discovery program. Natural products a
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de Jesus Freitas Sá, Hilzimar, Anne Karoline Maiorana Santos, Adriano Souza Fonseca, et al. "Assessment of Metabolic Alterations Induced by Halogenated Additives and Antifungal Activity of Extracts from the Endophytic Fungus Fusarium sp. Associated with Dizygostemon riparius (Plantaginaceae)." Metabolites 15, no. 7 (2025): 451. https://doi.org/10.3390/metabo15070451.

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Background/Objectives: Endophytic fungi are valuable sources of bioactive compounds with potential therapeutic applications. This study aimed to evaluate the antifungal activity of secondary metabolites produced by Fusarium sp. isolated from Dizygostemon riparius, with particular focus on the impact of culture medium supplementation with halogenated and metallic additives on metabolite production. Methods: The fungus was cultivated in standard Czapek medium and media supplemented with NH4Br or MnCl2. Methanolic extracts were obtained, fractionated, and chemically characterised via LC-ESI-HRMS.
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Kokil, Sachin, and Manish Bhatia. "Antifungal Azole Metabolites: Significance in Pharmaceutical and Biomedical Analysis." Journal of Medical Biochemistry 28, no. 1 (2009): 1–10. http://dx.doi.org/10.2478/v10011-008-0040-1.

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Antifungal Azole Metabolites: Significance in Pharmaceutical and Biomedical Analysis Individualised therapy and factors determining such variability among patients are confusing to both physicians and their patients because of the observed therapeutic, metabolic and toxic response. The same is true about antifungal azoles. They are under the influence and become targets of metabolic drug-drug interactions where more than one active form of the drug may be involved. The clinical relevance of these interactions may vary upon the azole involved and upon the intention of drug administration. The p
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Zhao, Jing, Ju Tang, Zhandi Wang, et al. "Extraction, analysis, and antifungal activity study of algae antibiotic active substances in plateau lakes." PLOS One 20, no. 5 (2025): e0319853. https://doi.org/10.1371/journal.pone.0319853.

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This study was carried out to assess the inhibitory activity of algae in plateau lakes against plant pathogenic fungi, and further conduct preliminary research and analysis on their antifungal active ingredients, in order to provide a certain basis for the development and utilization of algal secondary metabolite as anti-plant pathogenic fungal agents. Different solvent extraction methods using water, ethyl acetate, ethanol, and methanol were conducted to extract polyphenol metabolites from Ulothrix, Chlorella vulgaris, and Microcystis pseudofilamentosa Crow. The composition of the extracts wa
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7

Santos, Anne Karoline Maiorana, Bianca Araújo dos Santos, Josivan Regis Farias, et al. "Effect of Mn(II) and Co(II) on Anti-Candida Metabolite Production by Aspergillus sp. an Endophyte Isolated from Dizygostemon riparius (Plantaginaceae)." Pharmaceuticals 17, no. 12 (2024): 1678. https://doi.org/10.3390/ph17121678.

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Background/Objectives: This study evaluates the effect of Mn(II) and Co(II) ions on the production of anti-Candida metabolites by the endophytic fungus Aspergillus sp., isolated from Dizygostemon riparius. The objective was to identify metal-induced secondary metabolites with antifungal potential against drug-resistant Candida species. Methods: Aspergillus sp. was cultivated in Czapek agar supplemented with MnCl₂ (400 µM) or CoCl₂ (200 µM). Metabolite profiles were analyzed using UHPLC-DAD and LC-ESI-HRMS, followed by structural elucidation via NMR. Antifungal and biofilm inhibition activities
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8

Vargas Hoyos, Harold Alexander, Cristian David Grisales Vargas, Daniel Osorio Giraldo, María Alejandra Villamizar Monsalve, Juan Camilo Arboleda Rivera, and Ana María Mesa Vanegas. "Actinobacteria: Source of antifungal secondary metabolites for agricultural sustainability." Scientia Agropecuaria 16, no. 2 (2025): 307–26. https://doi.org/10.17268/sci.agropecu.2025.023.

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There is a need for new alternative sources of exogenous antifungals to replace those currently used in agriculture. Actinobacteria are gram-positive bacteria with a wide variety of secondary metabolites, which produce around two-thirds of all naturally occurring antibiotics in current clinical use, as well as many anticancer, anthelmintic and antifungal compounds. Consequently, these bacteria are of great importance for agricultural biotechnology, since they can be produced and applied in fields that do not promote resistance among fungi that attack plants. This review presents the research c
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9

Xiong, Zirui Ray, Mario Cobo, Randy M. Whittal, Abigail B. Snyder, and Randy W. Worobo. "Purification and characterization of antifungal lipopeptide produced by Bacillus velezensis isolated from raw honey." PLOS ONE 17, no. 4 (2022): e0266470. http://dx.doi.org/10.1371/journal.pone.0266470.

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Raw honey contains a diverse microbiota originating from honeybees, plants, and soil. Some gram-positive bacteria isolated from raw honey are known for their ability to produce secondary metabolites that have the potential to be exploited as antimicrobial agents. Currently, there is a high demand for natural, broad-spectrum, and eco-friendly bio-fungicides in the food industry. Naturally occurring antifungal products from food-isolated bacteria are ideal candidates for agricultural applications. To obtain novel antifungals from natural sources, we isolated bacteria from raw clover and orange b
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10

Whyte, Authrine C., Katherine B. Gloer, James B. Gloer, Brenda Koster, and David Malloch. "New antifungal metabolites from the coprophilous fungus Cercophorasordarioides." Canadian Journal of Chemistry 75, no. 6 (1997): 768–72. http://dx.doi.org/10.1139/v97-093.

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A chemical investigation of the coprophilous fungus Cercophorasordarioides has led to the isolation of arthrinone (1), a known fungal metabolite, and three new related compounds: 1-dehydroxyarthrinone (2), 3a,9a-deoxy-3a-hydroxy-1-dehydroxyarthrinone (3), and cerdarin (4). These metabolites were obtained from antifungal ethyl acetate extracts of liquid cultures of C. sordarioides through bioassay-guided fractionation, and their structures were assigned on the basis of 1D-NMR, HMQC, and HMBC results. Compounds 2 and 4 exhibited anti-Candida activity. Key words: antifungal, fungal metabolite, na
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11

Li, Hong-yu, Shigeki Matsunaga, and Nobuhiro Fusetani. "Antifungal Metabolites from Marine Sponges." Current Organic Chemistry 2, no. 6 (1998): 649–82. http://dx.doi.org/10.2174/1385272802666220130083412.

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Ease in collecting relatively large amounts of diverse species together with a high incidence of active samples has made marine sponges a good source of antifungal compounds. Although classical antimicrobial screening is now replaced by more disease-oriented sophisticated screening, many antifungal compounds with a wide structural diversity have been reported from marine sponges in the long history of the search for these compounds. In this review we describe antifungal compounds isolated from marine sponges since 1987 according to their structural types.
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12

Ghisalberti, Emilio L., and Catherine Y. Rowland. "Antifungal Metabolites from Trichoderma harzianum." Journal of Natural Products 56, no. 10 (1993): 1799–804. http://dx.doi.org/10.1021/np50100a020.

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13

Ragasa, Consolacion Y., Angel Lyn Kristin C. Co, and John A. Rideout. "Antifungal metabolites from Blumea balsamifera." Natural Product Research 19, no. 3 (2005): 231–37. http://dx.doi.org/10.1080/14786410410001709773.

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14

Pacciaroni, Adriana del V., María de los Angeles Gette, Marcos Derita, et al. "Antifungal activity ofHeterothalamus alienus metabolites." Phytotherapy Research 22, no. 4 (2008): 524–28. http://dx.doi.org/10.1002/ptr.2380.

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15

Jonathan, SG, Jonathan, SG, Omeonu FC Omeonu FC, Oshewolo O. Oshewolo O, et al. "Antifungal Activity of Secondary Metabolites from Lantana Camara L. against Bio-Deteriorating Fungi of Oryza Sativa L. (Nigerian Local Rice)." International Journal of Research and Innovation in Applied Science X, no. IV (2025): 453–69. https://doi.org/10.51584/ijrias.2025.10040038.

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Fungal contamination in rice can result in the production of mycotoxins, posing significant health risks to humans. This study investigated the antifungal efficacy of selected secondary metabolites, terpenoids, saponins, alkaloids, and flavonoids, as well as the antioxidant properties of Lantana camara L. against fungal pathogens in locally cultivated rice. The plant extract was obtained, and fungal pathogens were isolated and identified using standard microbiological techniques. Antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing Ability of Plasma
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16

Broberg, Anders, Karin Jacobsson, Katrin Ström, and Johan Schnürer. "Metabolite Profiles of Lactic Acid Bacteria in Grass Silage." Applied and Environmental Microbiology 73, no. 17 (2007): 5547–52. http://dx.doi.org/10.1128/aem.02939-06.

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ABSTRACT The metabolite production of lactic acid bacteria (LAB) on silage was investigated. The aim was to compare the production of antifungal metabolites in silage with the production in liquid cultures previously studied in our laboratory. The following metabolites were found to be present at elevated concentrations in silos inoculated with LAB strains: 3-hydroxydecanoic acid, 2-hydroxy-4-methylpentanoic acid, benzoic acid, catechol, hydrocinnamic acid, salicylic acid, 3-phenyllactic acid, 4-hydroxybenzoic acid, (trans, trans)-3,4-dihydroxycyclohexane-1-carboxylic acid, p-hydrocoumaric aci
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17

Widiantini, Fitri, Mia Rahmah Qadryani, Fuji Hartati, and Endah Yulia. "Antifungal Potency of Secondary Metabolites Produced by Endophytic Bacteria against Pathogenic Fungi Pyricularia oryzae Cav." Jurnal Perlindungan Tanaman Indonesia 23, no. 2 (2019): 185. http://dx.doi.org/10.22146/jpti.48392.

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Blast disease caused by Pyricularia oryzae Cav. is one of the most important diseases on rice. One of the alternative controlling methods in P. oryzae is biological control through the utilization of secondary metabolites produced by endophytic bacteria. The study aimed to determine the antifungal potency of secondary metabolites produced by rice endophytic bacteria against P. oryzae. The experiment was conducted using 9 endophytic bacteria isolated rice (Os1, Os2, Os3, Os4, Os5, Os6, Os7, Os8, and Os10). Each isolates were grown in ISP2 liquid media and the secondary metabolites compounds wer
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18

Kusumawati, Anggun Hari, Siti Kholillah, Farhamzah Mr., et al. "ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF Impatiens balsamina (L.): LITERATURE REVIEW ARTICLE." Bacterial Empire 5, no. 2 (2022): e334. http://dx.doi.org/10.36547/be.334.

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The human body contains a diverse range of microorganisms, including bacteria and fungi. The most common bacteria and fungi caused skin pathogens are Staphylococcus aureus, Propionibacterium acnes, Staphylococcus epidermis and Candida albicans. Many studies have found that Impatiens balsamina (L.) contains antibacterial and antifungal activities. Acne and Candidiasis are diseases that often arise and can interfere with comfort for sufferers. Usually, acne is caused by the bacteria Propionibacterium acnes, Staphylococcus epidermis and Staphylococcus aureus, and Candidiasis caused by the Candida
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19

Wang, Weichen, Jin Zhao, and Zhizi Zhang. "Bacillus Metabolites: Compounds, Identification and Anti-Candida albicans Mechanisms." Microbiology Research 13, no. 4 (2022): 972–84. http://dx.doi.org/10.3390/microbiolres13040070.

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Candida albicans seriously threatens human health, especially for immunosuppressed groups. The antifungal agents mainly include azoles, polyenes and echinocandins. However, the few types of existing antifungal drugs and their resistance make it necessary to develop new antifungal drugs. Bacillus and its metabolites has antifungal activity against pathogenic fungi. This review introduces the application of Bacillus metabolites in the control of C. albicans in recent years. Firstly, several compounds produced by Bacillus spp. are listed. Then the isolation and identification techniques of Bacill
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20

Hang, Sijin, Hui Lu, and Yuanying Jiang. "Marine-Derived Metabolites Act as Promising Antifungal Agents." Marine Drugs 22, no. 4 (2024): 180. http://dx.doi.org/10.3390/md22040180.

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The incidence of invasive fungal diseases (IFDs) is on the rise globally, particularly among immunocompromised patients, leading to significant morbidity and mortality. Current clinical antifungal agents, such as polyenes, azoles, and echinocandins, face increasing resistance from pathogenic fungi. Therefore, there is a pressing need for the development of novel antifungal drugs. Marine-derived secondary metabolites represent valuable resources that are characterized by varied chemical structures and pharmacological activities. While numerous compounds exhibiting promising antifungal activity
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Coleman, Jeffrey J., Suman Ghosh, Ikechukwu Okoli, and Eleftherios Mylonakis. "Antifungal Activity of Microbial Secondary Metabolites." PLoS ONE 6, no. 9 (2011): e25321. http://dx.doi.org/10.1371/journal.pone.0025321.

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22

Koval, Daniel, Milada Plocková, Jan Kyselka, Pavel Skřivan, Marcela Sluková, and Šárka Horáčková. "Buckwheat Secondary Metabolites: Potential Antifungal Agents." Journal of Agricultural and Food Chemistry 68, no. 42 (2020): 11631–43. http://dx.doi.org/10.1021/acs.jafc.0c04538.

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23

TAHARA, Satoshi, Shiro NAKAHARA, John L. INGHAM, and Junya MIZUTANI. "Fungal metabolites of antifungal isoflavone wighteone." Journal of the agricultural chemical society of Japan 59, no. 10 (1985): 1039–44. http://dx.doi.org/10.1271/nogeikagaku1924.59.1039.

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24

Liang, Yanqiong, Weihuai Wu, Rui Li, et al. "Evaluation of Bacillus subtilis Czk1 Metabolites by LC–MS/MS and Their Antifungal Potential against Pyrrhoderma noxium Causing Brow Rot Disease." Agriculture 13, no. 7 (2023): 1396. http://dx.doi.org/10.3390/agriculture13071396.

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Brown rot disease caused by Pyrrhoderma noxium is a widespread disease that severely affects the roots of rubber trees (Hevea brasiliensis Muell. Arg.). The economic losses, along with environmental and health problems arising from the use of disease control chemicals, have raised the interest of scholars to explore the use of biological control agents for the effective control of fungal pathogen P. noxium. Here, the inhibition effect of the culture filtrate of B. subtilis Czk1 on P. noxium was demonstrated. The findings indicate that the antifungal activity of this strain is mediated wholly o
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Mohanty, Niharika, Atmaja Elina Mishra, and Nibha Gupta. "ANTIFUNGAL POTENTIAL OF EXO-METABOLITES PRODUCED BY PENICILLIUM CAPSULATUM AGAINST PHYTOPATHOGENIC FUNGI." Acta Scientifica Malaysia 8, no. 2 (2024): 89–92. https://doi.org/10.26480/asm.02.2024.89.92.

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Fungi are well-known producers of secondary metabolites, commonly referred to as exo-metabolites, which play crucial roles in ecological interactions, including plant protection. Among these metabolites, many exhibit potent antifungal properties, making them effective biocontrol agents against phytopathogenic fungi that cause significant agricultural losses. This study investigates the antifungal potential of solvent extracts derived from the extracellular secondary metabolites of Penicillium capsulatum, specifically targeting five phytopathogenic fungi: Fusarium equseti, Fusarium acuminatum,
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Buatong, Jirayu, Vatcharin Rukachaisirikul, Suthinee Sangkanu, Frank Surup, and Souwalak Phongpaichit. "Antifungal Metabolites from Marine-Derived Streptomyces sp. AMA49 against Pyricularia oryzae." Journal of Pure and Applied Microbiology 13, no. 2 (2019): 653–65. http://dx.doi.org/10.22207/jpam.13.2.02.

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Siswadi, Edi, Gallyndra Fatkhu Dinata, Tri Rini Kusparwanti, Rindha Rentina Darah Pertami, Abdurrahman Salim, and Antika Wulandari. "Antifungal Activity of Secondary Metabolites From Trichoderma sp. Against Fusarium Oxysporum f.sp. Cubense." International Journal of Technology, Food and Agriculture 2, no. 2 (2025): 115–21. https://doi.org/10.25047/tefa.v2i2.5617.

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Fusarium oxysporum f.sp. cubense (Foc) is an important pathogenic fungus that causes Panama disease in banana. One approach to overcome this problem is to utilize secondary metabolites from Trichoderma sp. This research was conducted to determine the effect of administering secondary metabolites from Trichoderma sp. against pathogen Foc. These metabolites were applied at concentrations of 10%, 20%, and 30%, 40% alongside a fungicide active ingredient of phosphoric acid 400 SL. This study used a Completely Randomized Design with 6 treatments 4 repetition. The parameters observed included colony
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Hammad, Masooma, Hazrat Ali, Noor Hassan, et al. "Food safety and biological control; genomic insights and antimicrobial potential of Bacillus velezensis FB2 against agricultural fungal pathogens." PLOS ONE 18, no. 11 (2023): e0291975. http://dx.doi.org/10.1371/journal.pone.0291975.

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Development of natural, broad-spectrum, and eco-friendly bio-fungicides is of high interest in the agriculture and food industries. In this context, Bacillus genus has shown great potential for producing a wide range of antimicrobial metabolites against various pathogens. A Bacillus velezensis strain FB2 was isolated from an agricultural field of National Institute for Biotechnology and Genetic Engineering (NIBGE) Faisalabad, Pakistan, exhibiting good antifungal properties. The complete genome of this strain was sequenced, and its antifungal potential was assayed by dual culture method. Moreov
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DALIE, D. K. D., A. M. DESCHAMPS, V. ATANASOVA-PENICHON, and F. RICHARD-FORGET. "Potential of Pediococcus pentosaceus (L006) Isolated from Maize Leaf To Suppress Fumonisin-Producing Fungal Growth." Journal of Food Protection 73, no. 6 (2010): 1129–37. http://dx.doi.org/10.4315/0362-028x-73.6.1129.

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The present study was aimed at characterizing the ability of lactic acid bacteria isolated from maize to repress the growth of fumonisin-producing fungi. A total of 67 isolates were screened for their antifungal activity against Fusarium proliferatum and Fusarium verticillioides by using the overlay method. The most efficient antifungal isolate was identified as Pediococcus pentosaceus (L006), on the basis of physiological and biochemical characterization and 16S rRNA gene sequencing. Production of the antifungal metabolite by this isolate commenced at the end of the growth exponential phase (
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Sidorova, T. M., A. M. Asaturova, and V. V. Allakhverdyan. "Chromatographic profiles of antifungal exo- and endometabolites of Bacillus velezensis." TAURIDA HERALD OF THE AGRARIAN SCIENCES 2(26) (August 3, 2021): 191–99. http://dx.doi.org/10.33952/2542-0720-2021-2-26-191-199.

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The antifungal activity of the Bacillus bacteria is based on their ability to produce metabolites. Therefore, when selecting a strain that produces an effective biofungicide, it is necessary to assess the metabolism of bacteria. The aim of this work is to isolate exo- and endometabolites of the promising B. velezensis BZR 336g and B. velezensis BZR 517 strains and assess their antifungal activity. Studies were carried out in 2020–2021. The object of the study is a liquid culture of the B. velezensis BZR 336g and B. velezensis BZR 517 strains. Methods of liquid extraction, ascending thin layer
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Karimi, Ali, Torsten Meiners, and Christoph Böttcher. "Metabolite Profiling and Bioassay-Guided Fractionation of Zataria multiflora Boiss. Hydroethanolic Leaf Extracts for Identification of Broad-Spectrum Pre and Postharvest Antifungal Agents." Molecules 27, no. 24 (2022): 8903. http://dx.doi.org/10.3390/molecules27248903.

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Hydroethanolic leaf extracts of 14 Iranian Zataria multiflora Boiss. populations were screened for their antifungal activity against five plant pathogenic fungi and metabolically profiled using a non-targeted workflow based on UHPLC/ESI-QTOFMS. Detailed tandem mass-spectrometric analyses of one of the most active hydroethanolic leaf extracts led to the annotation of 68 non-volatile semi-polar secondary metabolites, including 33 flavonoids, 9 hydroxycinnamic acid derivatives, 14 terpenoids, and 12 other metabolites. Rank correlation analyses using the abundances of the annotated metabolites in
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Giordano, Ana Luisa Perini Leme, Marili Villa Nova Rodrigues, Karen Gabriela Araujo dos Santos, et al. "Enhancing Antifungal Drug Discovery Through Co-Culture with Antarctic Streptomyces albidoflavus Strain CBMAI 1855." International Journal of Molecular Sciences 25, no. 23 (2024): 12744. http://dx.doi.org/10.3390/ijms252312744.

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Fungal infections pose a growing public health threat, creating an urgent clinical need for new antifungals. Natural products (NPs) from organisms in extreme environments are a promising source for novel drugs. Streptomyces albidoflavus CBMAI 1855 exhibited significant potential in this regard. This study aimed to (1) assess the antifungal spectrum of the CBMAI 1855 extract against key human pathogens, (2) elicit NP production through co-cultivation with fungi, correlating the metabolites with the biosynthetic gene clusters (BGCs), and (3) perform in silico toxicity predictions of the identifi
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Farooq, Afgan, Iqbal Choudhary, Atta-ur Rahman, Satoshi Tahara, K. Hüsnü Can Başer, and Fatih Demirci. "Detoxification of Terpinolene by Plant Pathogenic Fungus Botrytis cinerea." Zeitschrift für Naturforschung C 57, no. 9-10 (2002): 863–66. http://dx.doi.org/10.1515/znc-2002-9-1018.

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Detoxification of an antifungal monoterpene terpinolene (1) by the plant pathogenic fungus Botrytis cinerea afforded hydroxlyated metabolites 2,3-dihydro-3β,6β-dihydroxy-terpinolene (2) (39%) and 2,3-dihydro-1α,3α-dihydroxy-terpinolene (3) (20%), respectively. Terpinolene showed good levels of antifungal activity while both the metabolites were inactive against another plant pathogenic fungus Cladosporium herbarum.
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Mitrović, I., J. Grahovac, J. Dodić, A. Jokić, Z. Rončević, and M. Grahovac. "Production of plant protection agents in medium containing waste glycerol by Streptomyces hygroscopicus: Bioprocess analysis." Acta Alimentaria 49, no. 3 (2020): 270–77. http://dx.doi.org/10.1556/066.2020.49.3.5.

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The surplus of waste glycerol, by-product of the biodiesel production process, is available at the global market. Some species of the genera Streptomyces have the ability to assimilate glycerol and convert it into valuable metabolic products. In the present study, the ability of Streptomyces hygroscopicus to assimilate waste glycerol and convert it into metabolic compounds with antifungal activity against four phytopathogenic fungi obtained from apple fruit samples expressing rot symptoms, was investigated. Production of antifungal metabolites by S. hygroscopicus was carried out in 3 l stirred
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Henkels, Marcella D., Teresa A. Kidarsa, Brenda T. Shaffer, et al. "Pseudomonas protegens Pf-5 Causes Discoloration and Pitting of Mushroom Caps Due to the Production of Antifungal Metabolites." Molecular Plant-Microbe Interactions® 27, no. 7 (2014): 733–46. http://dx.doi.org/10.1094/mpmi-10-13-0311-r.

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Bacteria in the diverse Pseudomonas fluorescens group include rhizosphere inhabitants known for their antifungal metabolite production and biological control of plant disease, such as Pseudomonas protegens Pf-5, and mushroom pathogens, such as Pseudomonas tolaasii. Here, we report that strain Pf-5 causes brown, sunken lesions on peeled caps of the button mushroom (Agaricus bisporus) that resemble brown blotch symptoms caused by P. tolaasii. Strain Pf-5 produces six known antifungal metabolites under the control of the GacS/GacA signal transduction system. A gacA mutant produces none of these m
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Sriwastava, Akanksha Raj, and Vivek Srivastava. "GC-MS Profiling and Antifungal Activity of Secondary Metabolite from Endophytic Fungus of Giloy." Biosciences Biotechnology Research Asia 18, no. 4 (2021): 651–59. http://dx.doi.org/10.13005/bbra/2948.

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The endophytic microbiota is considered to be one of the consistent and noble souce of potential and unique natural amalgams. These natural amalgams carry diverse pharmaceutical significance which the reason for their importance among research fields. The diversity of plants carries much more diversity of the endophytes as their mutual parts where both are benefited from each other. The current work deals with the isolation of the endophytic fungus from Tinospora cordifolia, for which the leaves were used after the surface sterilization, followed by the production of secondary metabolite by th
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Lumban Gaol, Josua Gabriel, Delianis Pringgenies, and Wilis Ari Setyati. "Screening for Antibacterial and Antifungal Activity in Fungi Associated with Molluscs." Jurnal Moluska Indonesia 9, no. 1 (2025): 1–7. https://doi.org/10.54115/jmi.v9i1.114.

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Molluscs are invertebrate organisms that produce secondary metabolites to adapt to their environment. These secondary metabolites are also found in fungi that live in symbiosis with molluscs. Research has shown that these symbiotic fungi produce various secondary metabolites with antibacterial and antifungal properties. This study aims to explore the potential of fungi associated with molluscs in developing bioprospecting strategies against pathogenic bacteria and fungi. The antibacterial and antifungal screening tests were conducted against the pathogenic bacteria Escherichia coli and Staphyl
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Tambunan, Venita Octavia, Meiskha Bahar, Andri Pramono, Cut Fauziah, Hany Yusmaini, and Fajriati Zulfa. "Potensi Daya Hambat Filtrat Zat Metabolit Actinomycetes dari Kebun Raya Bogor terhadap Pertumbuhan Candida albicans dan Malassezia furfur." Bioscientist : Jurnal Ilmiah Biologi 10, no. 1 (2022): 66. http://dx.doi.org/10.33394/bioscientist.v10i1.4792.

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Candida albicans and Malassezia furfur are types of fungi that often cause infections in humans. Widespread fungal infections and lack of therapeutic options can develop fungal resistance and become serious problems in the future. Actinomycetes are Gram-positive bacteria that can produce secondary metabolites such as antifungal, antibacterial, and anticancer. The study aimed to determine the effectiveness of the metabolite filtrate Actinomycetes as an antifungal agent against the in vitro growth of C.albicans and M. furfur. This type of research is a laboratory experimental study with a post-t
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Silva, Eliane O., Antonio Ruano-González, Raquel A. Dos Santos, et al. "Antifungal and Cytotoxic Assessment of Lapachol Derivatives Produced by Fungal Biotransformation." Natural Product Communications 11, no. 1 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100128.

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In the screening for biological active compounds, the biotransformation processes catalyzed by filamentous fungi are useful because they can provide information about the possible appearance of toxic metabolites after oral administration and also generate new leads. In this paper, biotransformation of lapachol (1) by three fungal strains, Mucor circinelloides NRRL3631, Botrytis cinerea UCA992 and Botrytis cinerea 2100, has been investigated for the first time. Lapachol (1) was biotransformed into avicequinone-A (2) by M. circinelloides, 3′-hydroxylapachol (3) by B. cinerea, and into dehydro-α-
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Karličić, Vera, Jelena Jovičić-Petrović, Igor Kljujev, et al. "Biocontrol potential of Bacillus amyloliquefaciens D5 ARV metabolites." Acta agriculturae Serbica 29, no. 57 (2024): 27–33. http://dx.doi.org/10.5937/aaser2357027k.

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Integrated pathogen management incorporates biological control and ecological services of plant growth-promoting bacteria as base components. The biocontrol activity of Bacillus amyloliquefaciens D5 ARV toward Fusarium oxysporum, Fusarium graminearum, Botrytis cinerea, and Macrophomina sp. was estimated through a confrontation test, and the potential of volatile and non-volatile organic compounds (VOCs). The results of the confrontation test showed 60, 46, 37, and 33% of F. oxysporum, F. graminearum, B. cinerea, and Macrophomina sp. growth inhibition, while VOCs effects reached 30%, 47%, 53%,
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Dubey, Olga, Sylvain Dubey, Sylvain Schnee, et al. "Plant surface metabolites as potent antifungal agents." Plant Physiology and Biochemistry 150 (May 2020): 39–48. http://dx.doi.org/10.1016/j.plaphy.2020.02.026.

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You, Fei, Ting Han, Jing-zhong Wu, Bao-kang Huang, and Lu-ping Qin. "Antifungal secondary metabolites from endophytic Verticillium sp." Biochemical Systematics and Ecology 37, no. 3 (2009): 162–65. http://dx.doi.org/10.1016/j.bse.2009.03.008.

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do Amaral, Samuel Cavalcante, Luciana Pereira Xavier, Vítor Vasconcelos, and Agenor Valadares Santos. "Cyanobacteria: A Promising Source of Antifungal Metabolites." Marine Drugs 21, no. 6 (2023): 359. http://dx.doi.org/10.3390/md21060359.

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Cyanobacteria are a rich source of secondary metabolites, and they have received a great deal of attention due to their applicability in different industrial sectors. Some of these substances are known for their notorious ability to inhibit fungal growth. Such metabolites are very chemically and biologically diverse. They can belong to different chemical classes, including peptides, fatty acids, alkaloids, polyketides, and macrolides. Moreover, they can also target different cell components. Filamentous cyanobacteria have been the main source of these compounds. This review aims to identify th
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Peng, Qian, Jing Yang, Qiang Wang, Huayi Suo, Ahmed Mahmoud Hamdy, and Jiajia Song. "Antifungal Effect of Metabolites from a New Strain Lactiplantibacillus Plantarum LPP703 Isolated from Naturally Fermented Yak Yogurt." Foods 12, no. 1 (2023): 181. http://dx.doi.org/10.3390/foods12010181.

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The antifungal effect of metabolites produced by a new strain of Lactiplantibacillus (Lpb.) plantarum LPP703, isolated from naturally fermented yak yogurt, was investigated. The results showed that Lpb. plantarum LPP703 significantly inhibited four fungal species, including Penicillium sp., Rhizopus delemar, Aspergillus flavus, and Aspergillus niger. The metabolites produced after 20 h of Lpb. plantarum LPP703 fermentation showed the highest antifungal activity against Penicillium sp. Compared with the control group, the Lpb. plantarum LPP703 metabolites-treated Penicillium sp. spores were sta
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Karioti, Anastasia, Helen Skaltsa, Diamanto Lazari, Marina Sokovic, Begoña Garcia, and Catherine Harvala. "Secondary Metabolites from Centaurea deusta with Antimicrobial Activity." Zeitschrift für Naturforschung C 57, no. 1-2 (2002): 75–80. http://dx.doi.org/10.1515/znc-2002-1-213.

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The aerial parts of Centaurea deusta Ten. afforded in addition to several known compounds, mainly sesquiterpene lactones, one new eudesmanolide and one new elemane derivative. Structures of the new compounds were elucidated by spectroscopic methods. The in vitro antifungal and antibacterial activities of the isolated compounds was tested, using the microdilution method. All compounds tested showed high antifungal activity.
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Amalia, Anisa Rizki, Arika Purnawati, Endang Triwahyu Prasetyawati, and Vika Yanti. "Secondary Metabolites of Trichoderma sp. as Antifungal Against Rice Seed-borne Pathogen Fungi." JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS 9, no. 3 (2023): 483–95. http://dx.doi.org/10.36987/jpbn.v9i3.4822.

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The use of quality seeds is necessary to increase rice productivity. The existence of pathogenic fungi infections causes the quality of rice seeds to decrease and impacts the ability to grow plants. Trichoderma sp. is known to produce secondary metabolites that can inhibit the growth of pathogens. This study aimed to examine the ability of the secondary metabolites of Trichoderma sp. at various concentration levels and immersion time to suppress pathogenic fungi infections carrying rice seeds. The research was carried out by giving seed immersion treatment. Then identify the pathogenic fungi t
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Zolotykh, Denis Sergeyevich, Dmitriy Igorevich Pozdniakov, Margarita Petrovna Glushko, and Жанна Владимировна Daironas. "CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF SECONDARY METABOLITES FROM IMPATIENS BALSAMINA." chemistry of plant raw material, no. 3 (September 26, 2022): 27–47. http://dx.doi.org/10.14258/jcprm.20220310518.

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The review summarizes the literature data concerning the chemical composition of secondary metabolites and the types of biological activity of extracts and separate groups of secondary metabolites of Impatiens balsamina. First, data are given concerning the different types of biological activity of the extracts. Further, individual groups of secondary metabolites are considered, the corresponding structural formulas and types of biological activity established for this group of secondary metabolites are given. An attempt has been made to present the material about chemical composition and type
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Jovicic-Petrovic, Jelena, Sanja Jeremic, Ivan Vuckovic, et al. "Aspergillus piperis A/5 from plum-distilling waste compost produces a complex of antifungal metabolites active against the phytopathogen Pythium aphanidermatum." Archives of Biological Sciences 68, no. 2 (2016): 279–89. http://dx.doi.org/10.2298/abs150602016j.

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Adding compost to soil can result in plant disease suppression through the mechanisms of antagonistic action of compost microflora against plant pathogens. The aim of the study was to select effective antagonists of Pythium aphanidermatum from compost, to assess the effect of its extracellular metabolites on the plant pathogen, and to characterize antifungal metabolites. The fungal isolate selected by a confrontation test was identified as Aspergillus piperis A/5 on the basis of morphological features and the internal transcribed spacer (ITS) region, ?-tubulin and calmodulin partial sequences.
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Alfizar, Alfizar, Amda Resdiar, Nana Ariska, et al. "EFFICACY ANTIMICROBIAL ENDOPHYTICS METABOLITES TO CONTROL SIGATOKA DISEASE (MYCOSPHAERELLA MUSICOLA) ON BANANAS IN NORTHERN SUMATERA." International Journal of Applied Science and Engineering Review 05, no. 03 (2024): 58–75. http://dx.doi.org/10.52267/ijaser.2024.5309.

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The secondary metabolites show diverse biological activities, including phytotoxic, antibacterial, antifungal, and antitumor. This study aimed to obtain secondary metabolites that are more effective in suppressing the development of Sigatoka disease in bananas. A field trial was performed to screen the antifungal metabolitesactivity of three isolates against Mycosphaerella musicola. This research used a randomised block design with four treatments and six replications. The results showed that the fastest incubation period was obtained at 14 days in the control treatment, and with Bacillus sp o
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Kgosiemang, Julius Leumo, Tshimangadzo Ramakuwela, Sandiswa Figlan, and Nicolene Cochrane. "Antifungal Effect of Metabolites from Bacterial Symbionts of Entomopathogenic Nematodes on Fusarium Head Blight of Wheat." Journal of Fungi 10, no. 2 (2024): 148. http://dx.doi.org/10.3390/jof10020148.

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Fungal diseases such as Fusarium head blight (FHB) are significant biotic stressors, negatively affecting wheat production and quality. This study explored the antifungal activity of the metabolites produced by the bacterial symbionts of entomopathogenic nematodes (EPNs) against FHB-causing Fusarium sp. Fusarium graminearum. To achieve this, the symbiotic bacteria of nine EPN isolates from the EPN collection at the Agricultural Research Council-Small Grains (ARC-SG) were isolated from the cadavers of Galleria mellonella (Lepidoptera: Pyralidae) larvae after infection with EPNs. Broth cultures
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