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Dissertations / Theses on the topic 'Antigen tolerance'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Divekar, Rohit Dilip Zaghouani Habib. "Two aspects of peripheral immune tolerance systemic and mucosal tolerance mechanisms /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6868.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010). Vita. Thesis advisor: Habib Zaghouani. "May 2008" Includes bibliographical references.

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2

Chen, Tse-Ching. "Dominant tolerance to a minor histocompatibility antigen." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400052.

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3

Whitley, Nathaniel T. "Mechanisms in antigen-specific tolerance induction therapy." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411069.

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4

Matriano, James Abcede. "Peripheral tolerance to an organ-specific antigen." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1059484721.

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5

Ferry, Helen. "B cell tolerance to systemic, intracellular self-antigen." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442947.

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6

Marshall, Naomi Jane. "Antigen presentation in autoimmune disease." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4212.

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The aim of my project was to examine the extent to which endogenous expression of a largely renal-specific antigen influences the repertoire in adulthood of autoreactive T cells specific to that antigen. The renal-specific antigen, human α3(IV)NC1, is the target of autoimmune attack in Goodpasture’s disease. This protein was expressed and purified in recombinant (using bacterial and mammalian cell expression systems) and purified in native (extracted from human tissue) forms. Transgenic mice were generated that express HLA-DR15 (associated with Goodpasture’s disease) as their sole MHC class II

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7

Wheeler, Paul Richard. "Characterisation of T cell anergy in allo-antigen specific CD4âº cells." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288516.

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8

Konkel, Joanne Elizabeth. "Signals required for the induction of antigen-based therapeutic tolerance." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3942.

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Despite the actions of central tolerance during thymic selection, it is clear that the peripheral T cell repertoire contains significant numbers of self-reactive T cells. The immune system needs to curtail the risk of autoimmune disease by controlling the activity of these self-reactive T cells. Various mechanisms are in place to achieve this control (peripheral tolerance). Activation of CD4+ T cells requires two signals; engagement of the T cell receptor (TCR) with an appropriate peptide:MHC complex (signal 1), and the aggregate effect of multiple signals generated following ligation of costi

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9

Yuschenkoff, Victoria Nicole. "Tolerance Induction to a Foreign Protein Antigen: Analysing the Role of B Cells in Establishing Peripheral Tolerance." eScholarship@UMMS, 1995. http://escholarship.umassmed.edu/gsbs_diss/298.

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Tolerance to self proteins is largely dependent upon the deletion of immature, self-specific T and B cells in the thymus and bone marrow. Although highly efficient, the elimination of these self-reactive lymphocytes is dependent on the expression of their target antigen in these primary lymphoid organs. Many proteins, however, such as hormones, are developmentally regulated and expressed at different stages of life, while other proteins are expressed outside the thymus and marrow. To ensure self-tolerance, other mechanisms must exist to inactivate or prevent the activation of mature, potential

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10

Sefia, Eseberuo. "Mechanism of immune tolerance induction in antigen-specific human autoimmune disease." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8982.

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Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system and is considered to be a T-cell mediated autoimmune disease. The “ideal” method in treating MS would be an antigen-specific therapy that does not require generalized immunosuppression. To date there are no definitive treatments for MS but there are several licensed therapies such as -interferon. Unfortunately the effect of interferon (IFN) is reduced by the development of neutralizing antibodies (NAbs) in up to 35% of MS patients within two years of starting treatment. An immunization schedule was d

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11

Lau, Annie Wai-Ting. "The role of antigen presentation in the induction of immune tolerance." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485395.

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Experimental Autoimmune Dveoretinitis (EAD), a CD4+ T cell-mediated retinaspecific disease, is a model for the sight-threatening human posterior uveitis. Dendritic cells (DC) are key regulators of immune responses. Mature DC are traditionally considered to be immunogenic due to their ability to directly activate naIve T cells, though there is accumulating evidence that mature DC can also be tolerogenic and induce antigen-specific regulatory T cells (Treg). Although many studies have demonstrated that systemic administration of DC can suppress the induction ofautoimmune disease, the mechanism o

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12

Eynon, Elizabeth E. "Small B Cells as Antigen Presenting Cells in the Induction of Tolerance to Soluble Protein Antigens: A Dissertation." eScholarship@UMMS, 1991. https://escholarship.umassmed.edu/gsbs_diss/185.

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This thesis proposes a mechanism for the induction of peripheral tolerance to protein antigens. I have investigated the mechanism of tolerance induction to soluble protein antigens by targeting an antigen to small, resting B cells. For this purpose I have used a rabbit antibody directed at the IgD molecule found on the surface of most small, resting B cells but missing or lowered on activated B cells. Intravenous injection of normal mice with 100 μg of an ultracentrifuged Fab fragment of rabbit anti-mouse IgD (Fab anti-δ) makes these mice profoundly tolerant to challenge with nonimmune rabbit

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13

Harper, Helen Margaret. "The induction of immune responses in the murine small intestine." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389589.

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14

McPherson, Rhoanne Catherine. "Effect of tolerogenic peptide administration on pathogenic antigen-experienced T cells." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8199.

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The administration of soluble antigenic peptides is known to be effective at inducing tolerance in naïve antigen-reactive CD4+ T cells. This observation forms the basis of antigen-based therapy, which offers the potential to specifically target the auto-reactive CD4+ T cells involved in driving autoimmune disease pathogenesis, whilst leaving the rest of the immune system intact. The prophylactic administration of soluble autoantigen-derived peptides has proven to be effective at inhibiting disease induction in various experimental models of autoimmune disease. However, the clinical requirement

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15

Verbeke, Catia Stéphanie. "Antigen-specific immune modulation using an injectable biomaterial." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11456.

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The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific tolerance has remained elusive. A therapy that could prevent the immune system from aberrantly destroying self-tissues, without impairing its capacity to eliminate dangerous pathogens, would be transformative for the treatment of autoimmune diseases. In addition, such a therapy could also greatly advance the field of organ transplantation by inducing antigen-specific t

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16

Winnewisser, Julia [Verfasser], and Ludger [Akademischer Betreuer] Klein. "Central tolerance induction to the self-antigen PLP / Julia Winnewisser ; Betreuer: Ludger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/112092362X/34.

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17

Dieti, Anastasia. "Influence of guar galactomannan on antigen absorption and induction of immunological oral tolerance." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433117.

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18

Walker, Kenneth G. "Intrathymic injection of donor antigen as a technique for prolonging cardiac allograft survival in the rat." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265536.

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In this study we have reproduced the prolongation of graft survival by ITI in a rat heart transplant model in which an ITI of an optimal number of donor bone-marrow cells (BMC) was given together with 1ml ALS IP 14 days before transplant. The efficacy of this protocol was critically dependent on the donor-recipient haplotype and influenced by antigenic strength and MHC disparity but not by non-MHC background genes. In strain disparities where ITI was unsuccessful, this was caused by alloreactive recent thymic emigrant cells. In a high responder strain combination the effect was highly dependen

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19

Bushell, Andrew Richard. "Transplantation tolerance in the mouse induced by antigen and anti-CD4 antibody : mechanisms and strategies." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335772.

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20

Rovere, Querini Patrizia. "Clearance of dying cells by antigen presenting and scavenger phagocytes : implications for autoimmunity and tolerance." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323272.

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21

Dresch, Christiane. "Antigen-specific tolerance induction by transcriptional targeting of dendritic cells with a novel lentiviral vector." Diss., kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9310/.

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22

Nishimura, Eiji. "Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3[+]CD25[+]CD4[+] regulatory T cells." Kyoto University, 2004. http://hdl.handle.net/2433/145292.

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23

Carl, Joseph William Jr. "ON THE ROLE OF CD24 IN THE PATHOGENICITY OF MYELIN ANTIGEN SPECIFIC T CELLS." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1210699484.

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24

Seamons, Audrey. "Implications of myelin basic protein processing and presentation on T cell activation and tolerance /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/10851.

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25

Teng, Yen-Tung Andy. "Analysis of the mechanism(s) of immunological tolerance to a physiological soluble antigen in transgenic mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/Nq27740.pdf.

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26

Marelli-Berg, Frederica Maria. "Antigen presentation by parenchymal cells as a mechanism for the induction and maintenance of peripheral tolerance." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266255.

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27

Berbudi, Afiat [Verfasser]. "Filarial infection and filarial antigen administration promotes glucose tolerance in diet-induced obese mice / Afiat Berbudi." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080561366/34.

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28

Henry, Emmanuelle. "Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210584.

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Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCs to express the immunosuppressive cytokine IL-10 and tested the ability of these cells to control experimental asthma. A single intratracheal injection of OVA-pulsed IL-10-transduced DCs (OVA-IL-10-DCs) to naive mice prior to OVA sensitization and challenge prevented all the cardinal features of airway allergy, namely eosinophilic airway inflammation, airway hyperreactivity, and production of mucus,

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29

Rizzuto, Gabrielle Ann. "Self-antigen specific CD8+ T cell precursor : frequency determines the quality of the anti-tumor immune response /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1621818951&sid=3&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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30

Kaye, P. M. J. "Particle mediated co-delivery of IL-10 and antigen inhibits T cell activation but fails to induce tolerance." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302067/.

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Immune disorders such as allergy and autoimmunity are becoming increasingly common in developed countries. Self-reactive T cells exist in both healthy and autoimmune individuals. It is generally understood that hyperimmune disorders are caused by insufficient regulation, namely loss of activity of regulatory T cells. Whilst regulatory T cells exist naturally it is also possible to induce them both in vitro and in vivo. Immunotherapeutic techniques aim to provide noninflammatory exposure of antigen to the immune system with the aim of inducing antigen-specific regulatory T cells. Interleukin-10

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31

Ha, Hong Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis." Awarded by:University of New South Wales. Clinical School - St Vincent's Hospital, 2007. http://handle.unsw.edu.au/1959.4/40871.

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Idiopathic Membranous nephropathy (MN) is a common cause of nephrotic syndrome in humans, and many patients progress to end-stage kidney disease. The best available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's adjuvant (CFA). Rats develop heavy proteinuria, a key measure of glomerular damage, and the disease is histologically identical to human MN. It has been thought that HN is mediated by antibody-based mechanisms. More recent evidence demonstrates a critical role for cytotoxic T cells. This thesis aims

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32

Boardman, Dominic Anthony. "Generation of MHC class I allospecific regulatory T cells using chimeric antigen receptors, tools for eliciting targeted transplant tolerance." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/generation-of-mhc-class-i-allospecific-regulatory-t-cells-using-chimeric-antigen-receptors-tools-for-eliciting-targeted-transplant-tolerance(64bd3dfe-1285-4b28-a4f2-39b31fd70bc3).html.

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Regulatory T cells (Treg) therapy using autologous Tregs expanded ex vivo is currently being assessed clinically as a means of limiting graft rejection. However, pre-clinical data has demonstrated that graft-specific Tregs protect from graft rejection more effectively than polyclonal Tregs. Chimeric antigen receptor (CAR) technology is currently being investigated clinically as a means of conferring tumour antigen-specificity onto T cells in cancer research. CARs are synthetic fusion proteins which translate the engagement of extracellular target antigens into the activation of intracellular T

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33

Kodituwakku, Aruna Poojitha. "Antigen specific B cells in the immune response to Haemophilus influenzae type b PRP conjugate vaccine /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phk769.pdf.

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34

Lute, Kenneth D. "Costimulation and tolerance in T cell immunotherapy." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1141850521.

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35

Loschko, Jakob [Verfasser], Anne [Akademischer Betreuer] Krug, Dirk [Akademischer Betreuer] Haller, and Diana [Akademischer Betreuer] Dudziak. "Antigen targeting to plasmacytoid dendritic cells - induction of tolerance or immunity / Jakob Loschko. Gutachter: Dirk Haller ; Diana Dudziak. Betreuer: Anne Krug." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/101958839X/34.

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36

Wang, Lei [Verfasser], and Ludger [Akademischer Betreuer] Klein. "Mechanisms of central and peripheral T cell tolerance to an antigen of the central nervous system / Lei Wang ; Betreuer: Ludger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1128074060/34.

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37

Saitovitch, David. "Transplantation tolerance : an experimental model exploring mechanisms of its induction and maintenance after pretreatment with donor antigen and anti-CD4 antibodies." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308688.

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38

Baird, Allison Michelle. "Analysis of Low Zone Tolerance in Normal and B Cell-Deficient Mice." eScholarship@UMMS, 1996. https://escholarship.umassmed.edu/gsbs_diss/142.

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This thesis investigates the role of B cells as antigen-specific antigen-presenting cells (APC) in self tolerance to low concentrations of soluble self proteins and in acquired tolerance to low doses of soluble foreign protein antigens. Experiments were performed in normal and B cell-deficient animals, and tolerance induction was measured by T cell proliferation assays. T cell proliferation was reduced in B cell-deficient mice, indicating that B cells may be involved in efficient activation of naive T cells in response to protein antigen both in vivo and in vitro. To study acquired tolerance i

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39

Blish, Catherine Anne. "Modulation of T cell function and T cell receptor repertoire during the induction of peripheral tolerance /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8323.

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40

Shakhawat, Ayesha. "Function and regulation of human leukocyte antigen G in trophoblast derived cells : A model for the study of human feto-maternal tolerance." Thesis, University of Essex, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520116.

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41

Casacuberta, Serra Sílvia. "Antigen-specific mdscs induce immunological tolerance in an experimental model of multiple sclerosis. generation of human mdscs from hematopoietic progenitors as a therapeutic tooll." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/384609.

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En estudis previs realitzats en el nostre laboratori vam demostrar que la infusió de cèl·lules de medul·la òssia (MO) transduïdes amb un autoantigen (MOG40-55), dirigit a la via de presentació d'antígens per MHC de classe II, induïen tolerància immunològica en un model experimental d'esclerosi múltiple, la encefalomielitis autoimmune experimental (EAE), tant en un abordatge preventiu com terapèutic (Eixarch et al. 2009). Per altra banda, l'absència d'empelt de les cèl·lules que expressaven la MOG va permetre eliminar la mieloablació i ens va conduir a la hipòtesis de que l'efecte terapèutic ob

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42

Zheng, Xincheng. "Two-signal requirement for the development of T lymphocytes." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1109258062.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 156 p.; also includes graphics (some col.) Includes bibliographical references (p. 127-156). Available online via OhioLINK's ETD Center

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43

Haßler, Tobias Johannes [Verfasser], and Ludger [Akademischer Betreuer] Klein. "How central tolerance shapes the polyclonal CD4 T cell repertoire specific for the central nervous system antigen myelin proteolipid protein 1 / Tobias Johannes Haßler ; Betreuer: Ludger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1233200860/34.

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44

Cabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.

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45

Hässler, Signe. "Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7218.

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<p>Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. In these studies we have investigated the peripheral tolerance mechanisms controlled by the autoimmune regulator

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46

Marguti, Ivo. "Efeito das células dendríticas na geração de células T CD4+CD25+Foxp3+." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18102007-154828/.

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As células dendríticas (DCs) são as principais células apresentadoras de antígeno do sistema imune. No entanto, trabalhos têm demonstrado seu envolvimento na manutenção da tolerância imunológica. As células T CD4+CD25+Foxp3+ possuem a capacidade de suprimir respostas imunes. Neste estudo avaliamos as alterações ocorridas na população de células T CD4+CD25+Foxp3+ após co-cultura de células de linfonodo com DCs. Nossos resultados demonstram que após a co-cultura há um aumento da população de células CD4+CD25+Foxp3+ de maneira independente do estado de ativação das DCs ou da presença de antígenos

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47

Gallegos, Alena M. "Central tolerance to tissue-specific antigens /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8353.

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48

Steinhoff, Ulrich Johannes. "Von Toleranz zur Autoimmunität." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13835.

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Immunologische Toleranz ist eine elementare Eigenschaft des Immunsystems, die primär durch die klonale Deletion autoreaktiver T-Zellen im Thymus gewährleistet wird. Neben diesem als zentrale Toleranz bezeichneten Mechanismus, verfügt ein Organismus gleichzeitig über periphere Toleranzmechanismen wie Ignoranz, Anergie und regulatorische T-Zellen. Trotz dieser Kontrollmechanismen können in bestimmten Situationen autoreaktive CD4+ und CD8+ T-Zellen aktiviert werden und meistens zu örtlich und zeitlich begrenzten Autoimmunreaktionen führen. Ursache hierfür kann die hormonelle Regulation oder das g

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49

Honey, Karen J. "Mechanisms of transplantation tolerance." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301519.

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50

Sadissou, Ibrahim Abiodoun. "Influence de l’antigène leucocytaire humain (HLA-G) sur la sensibilité au paludisme chez la femme enceinte et le nouveau-né." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P628.

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L’objectif général de cette thèse était d’étudier le rôle de la protéine soluble HLA-G (sHLA- G) dans la variabilité des réponses à l’infection par P. falciparum chez la femme enceinte et son nouveau-né pendant ses deux premières années de vie. Précisément, nous avons étudié, chez les mères pendant la grossesse et leurs nourrissons de la naissance à 2 ans, les relations entre les niveaux de sHLA-G et l’infection palustre au niveau périphérique et placentaire. Nous avons également étudié les polymorphismes génétiques situés dans la région 3’UTR du gène HLA- G chez les mères et leurs nourrissons

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