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Journal articles on the topic 'ANTIHISTAMINE DRUGS'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Oktovina, Magdalena Niken, Fitra Annisa, and Nurwulan Adi Ismaya. "PENGGUNAAN ANTIHISTAMIN DAN OBAT LAINNYA PADA PASIEN DEWASA DI APOTEK SINAR MUTIARA APOTIK GUNUNG SINDUR, BOGOR." Edu Masda Journal 7, no. 1 (2023): 56. http://dx.doi.org/10.52118/edumasda.v7i1.187.

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Antihistamines are a class of drugs that can block the effects of histamine by blocking histamine receptors, in various allergic events. The use of antihistamines has a side effect of drowsiness, but this group is not recommended in the management of insomnia or difficulty sleeping because it can cause tolerance. The use of antihistamines is accompanied by other drugs to support the success of therapy, so it is necessary to monitor the use of antihistamines in remote areas such as Gunung Sindur through one of the pharmacies. This study was to determine the characteristics of antihistamine user

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Khan, Shafat Ahmad, Syed Dilshad Alam, Muralidhararao Bagadi, Rushda Anjum, and Mohd Yusuf. "Chromatographic Separation of Antihistamine Drugs using HPLC." Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry 1, no. 2 (2024): 22–27. http://dx.doi.org/10.55559/jjbrpac.v1i2.252.

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The chromatographic separation of antihistamine drugs using High-Performance Liquid Chromatography (HPLC) has garnered significant attention due to its pivotal role in pharmaceutical analysis. Antihistamines, vital in managing allergic disorders, present complex challenges in terms of analytical assessment owing to their diverse chemical structures and stereochemistry. This review aims to provide an overview of one of the best methodologies employed in HPLC-based separation of antihistamine drugs. Emphasis is placed on the separation of both nonracemic and racemic forms, considering their dist

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Maeda, Toshiki, Akira Babazono, and Takumi Nishi. "Surveillance of First-Generation H1-Antihistamine Use for Older Patients with Dementia in Japan: A Retrospective Cohort Study." Current Gerontology and Geriatrics Research 2018 (July 2, 2018): 1–6. http://dx.doi.org/10.1155/2018/3406210.

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Background. This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan. Methods. The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study period after being diagnosed with dementia. We investigated the cumulative number of oral H1-antihistamines administered and the relationship between first-generation H1-antihistamine use and each explanatory variable using crude and adjusted odds r

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Oyekan, P. J., H. C. Gorton, and C. S. Copeland. "Over-the-counter antihistamines in drug-related deaths: a population-based case series." International Journal of Pharmacy Practice 29, Supplement_1 (2021): i30—i31. http://dx.doi.org/10.1093/ijpp/riab015.037.

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Abstract Introduction Antihistamines are not one of the medicine groups reported on in the Office for National Statistics drug-related death data. (1) However, there is concern that first-generation antihistamines are misused for their sedative properties. This is amplified by a recent social media challenge, which resulted in deaths due to diphenhydramine overdose. (2) The extent of the involvement of antihistamines in deaths is largely unknown. Aim We aimed to evaluate deaths related to antihistamines in England (2000–2019) by individual drug, medicine classification (POM, P, GSL), whether t

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Shabanov, D. V., and Ju E. Lutkovskaya. "Actual antihistamine therapy." Meditsinskiy sovet = Medical Council, no. 16 (November 14, 2020): 26–35. http://dx.doi.org/10.21518/2079-701x-2020-16-26-35.

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The significance of the issues of allergic diseases is not in doubt. It is difficult to find a person who has not suffered at least some Allergy symptom, not everyone develops diseases, but most people face Allergy symptoms. The prevalence of various allergic diseases is increasing every year, currently reaching 30% of the population, and the world health organization predicts it will reach 50% in the next few decades. The most common nosologies are allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria, but there are many other conditions of hypersensitivity. This article addresses

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Vuković, Milana, Dunja Vesković, Nemanja Todorović, et al. "Comparative analysis of the consumption of antihistamines for systemic use in the Republic of Serbia and Nordic countries in the period 2009-2019." Hospital Pharmacology - International Multidisciplinary Journal 10, no. 1 (2023): 1250–63. http://dx.doi.org/10.5937/hpimj2301250v.

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Introduction: According to the ATC system of drug classification, group R06 includes H1 antihistamines for systemic use, which are divided into drug groups of the 1st and 2nd generation. Aim: Since there are no national guidelines in Serbia, for treating most allergic diseases, our aim was to compare pharmaceutical products and treatment strategies of systemic antihistamines use in Serbia with that in the Nordic countries that have been recognized as countries with good pharmacoeconomic practice. Material and methods: Data on drug consumption in the Republic of Serbia, the Kingdom of Norway, t

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Brahmbhatt, Harsh K., Nidhi Patel, Tejas K. Patel, and Tantul Sarkar. "Premedication of Ranitidine and the Action of Hypersensitivity Reactions to Paclitaxel." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1646–49. http://dx.doi.org/10.25258/ijddt.13.4.79.

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Paclitaxel is used asa chemotherapeutic agent for curing various types of cancer. To reduce the hypersensitivity of the chemotherapeutic effect, premedication of antihistaminic drugs like ranitidine, cetirizine, diphenhydramine, fexofenadine and desloratadine are prescribed. The antihistaminic drugs are given as premedication to prevent the formation of hives on the body. Ranitidine can be replaced by another antihistaminic drug which reduces the side effects and increases the efficacy of the drug. Studies were conducted comparing the antihistamine and non-antihistamine groups and tests like t

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8

Cho, Kyoo H., Ji E. Lee, Sook K. Song, and Phil Hyu Lee. "Chorea induced by antihistamine drugs." Movement Disorders 25, no. 4 (2010): 519–20. http://dx.doi.org/10.1002/mds.22965.

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9

Kareva, E. N. "Pharmacological optimization of antihistamine profile." Russian Medical Inquiry 6, no. 2 (2022): 92–97. http://dx.doi.org/10.32364/2587-6821-2022-6-2-92-97.

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Antihistamines are the first-line treatment for allergic diseases. The optimization of pharmacological properties of these pharmacotherapeutics is provided by the synthesis of new molecules with better safety profile (no penetration via the blood-brain barrier or less risk of drug interactions) or more selective affinity to H1-receptors (active optical isomer). In real clinical practice, drugs with extrahepatic metabolism have an advantage, the effectiveness of which does not depend on concomitant therapy, and the maximum concentration is reached in the shortest possible time, which ensures a

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10

Zhang, Weihong, Bingxue Li, Liang Liu, and Xiubao Ren. "Impact of concomitant H1 antihistamine administered during initiation of immune checkpoint inhibitor therapy on survival outcome and safety in patients with advanced primary lung cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e20532-e20532. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20532.

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e20532 Background: Antihistamines alleviate the side effects of antitumor drugs and have some antitumor effects. However, they have rarely been tested in combination with other antitumor therapies, especially immunotherapy. Methods: We compared the progression-free survival (PFS) and overall survival (OS) of patients with advanced primary lung cancer (stage III or IV) receiving immunotherapy with H1 antihistamine diphenhydramine alone (n = 40) or in combination with H2 antihistamine cimetidine (n = 69) [experimental group] to those receiving immunotherapy alone (n = 75) or with a H2 antihistam

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Kim, Ju Hee, Eun Kyo Ha, Boeun Han, et al. "First-Generation Antihistamines and Seizures in Young Children." JAMA Network Open 7, no. 8 (2024): e2429654. http://dx.doi.org/10.1001/jamanetworkopen.2024.29654.

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ImportanceThe widespread use of antihistamines in children for treatment of common cold symptoms and their central nervous system effects, like drowsiness, underscore the importance of being aware of the associated risks.ObjectiveTo assess associations between prescriptions of first-generation antihistamines and seizures in children using a comprehensive and nationwide dataset.Design, Setting, and ParticipantsThis cohort study used a self-controlled case-crossover design. Data were obtained from the National Health Insurance Service database in Korea. Children born between January 1, 2002, and

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Tsarev, S. V. "Antihistamine therapy in pediatric practice." Medical Council, no. 11 (July 16, 2018): 136–39. http://dx.doi.org/10.21518/2079-701x-2018-11-136-139.

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The article considers the role of histamine in the pathogenesis of allergic diseases and other pathological conditions. The mechanisms that contribute to the development of skin itching are considered separately. The article also shows the role and function of H1-histamine receptor blockers in the treatment of allergic diseases and pseudo allergic reactions. The mechanism of action, indications, contraindications and side effects of the antihistamine therapy are presented. The article also discusses the difference in first and second-generation antihistamines and shows the possible advantages

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13

Stahl, Stephen M. "Selective Histamine H1 Antagonism: Novel Hypnotic and Pharmacologic Actions Challenge Classical Notions of Antihistamines." CNS Spectrums 13, no. 12 (2008): 1027–38. http://dx.doi.org/10.1017/s1092852900017089.

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Numerous “antihistamines” as well as various psychotropic medications with antihistamine properties are widely utilized to treat insomnia. Over-the-counter sleep aids usually contain an antihistamine and various antidepressants and antipsychotics with antihistamine properties have sedative-hypnotic actions. Although widely used for the treatment of insomnia, many agents that block the histamine H1 receptor are also widely considered to have therapeutic limitations, including the development of next-day carryover sedation, as well as problems with chronic use, such as the development of toleran

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Lisni, Ida, Ani Anggriani, and Regina Puspitasari. "KAJIAN PERESEPAN OBAT ANTIHISTAMIN PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT DI BANDUNG." Jurnal Riset Kefarmasian Indonesia 2, no. 2 (2020): 52–62. http://dx.doi.org/10.33759/jrki.v2i2.77.

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Histamine is one of the factors that cause acute and chronic disorders, so it is necessary to investigate further the mechanism of antihistamines in the treatment of allergic diseases. Antihistamines are substances that can reduce or block the effects of histamine on the body by blocking histamine receptors. Antihistamines are one of the drugs that are often prescribed to children to the elderly. Thus the application of therapy in medicine is needed to ensure the use of appropriate drugs to prevent the occurrence of medication errors so that the goal of therapeutic effectiveness can be achieve

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Assadi, Sara, Latif Rahman, Mark Kong, and Sukaina Asad. "Could the Use of Antihistamines Have Triggered Reversible Cerebral Vasoconstriction Syndrome? A Case Report." Case Reports in Acute Medicine 4, no. 2 (2021): 50–57. http://dx.doi.org/10.1159/000517115.

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A 38-year-old woman presented to the emergency department with recurrent severe headaches. Although initial computer tomography (CT) brain imaging was unremarkable, a later CT venogram demonstrated a small subarachnoid haemorrhage. Magnetic resonance angiogram (MRA) brain imaging subsequently confirmed reversible cerebral vasoconstriction syndrome (RCVS). In the acute setting, RCVS rarely falls into a differential diagnosis for headache presentations, as in this case. The radiological variability can make diagnosis of RCVS challenging. However, there are clinical consistencies that can aid phy

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Li, Meng, Junyuan Zhang, Siman Ma, Zhen Jiang, Xin Di, and Xingjie Guo. "Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS." New Journal of Chemistry 44, no. 15 (2020): 5819–27. http://dx.doi.org/10.1039/d0nj00095g.

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Piplani, Sakshi, Puneet Singh, David A. Winkler, and Nikolai Petrovsky. "Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase." International Journal of Molecular Sciences 23, no. 14 (2022): 7704. http://dx.doi.org/10.3390/ijms23147704.

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Repurposing of existing drugs is a rapid way to find potential new treatments for SARS-CoV-2. Here, we applied a virtual screening approach using Autodock Vina and molecular dynamic simulation in tandem to screen and calculate binding energies of repurposed drugs against the SARS-CoV-2 helicase protein (non-structural protein nsp13). Amongst the top hits from our study were antivirals, antihistamines, and antipsychotics, plus a range of other drugs. Approximately 30% of our top 87 hits had published evidence indicating in vivo or in vitro SARS-CoV-2 activity. Top hits not previously reported t

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Kubanov, A. A., and V. V. Chikin. "The benefit of H2 receptors antagonist Rupatadine in treatment for urticaria." Vestnik dermatologii i venerologii 90, no. 3 (2014): 116–20. http://dx.doi.org/10.25208/0042-4609-2014-90-3-116-120.

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Second generation antihistamine drugs are mainly used for the therapy of patients suffering from urticaria; however, they are efficient in 45-60% of cases only. New drugs for treatment of urticaria need to be developed and implemented, and second generation antihistamine drug Rupatadine is one of them. At the same time, Rupatadine efficiently inhibits the inflammatory action of the platelet-activating factor. Due to its double action, Rupatadine used perorally in the dose of 10 mg once a day is an efficient drug for treatment of urticaria, and its safety was confirmed by clinical trials.

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19

Nightingale, Charles H. "Treating Allergic Rhinitis with Second‐Generation Antihistamines." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 16, no. 5 (1996): 905–14. http://dx.doi.org/10.1002/j.1875-9114.1996.tb03008.x.

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Allergic rhinitis afflicts close to 40% of the nation's population and costs more than $1.8 billion a year. The toll exacted by this disorder has been greatly alleviated by nonsedating second‐generation antihistamines loratadine, terfenadine, and astemizole. The three agents effectively reduce symptoms without the sometimes intolerable adverse effects of older drugs, but they are not completely equivalent. For example, terfenadine requires twice/day dosing, whereas the others can be given once/day. Astemizole has a slow onset and extremely prolonged duration of action. Both terfenadine and ast

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Renz, Cheryl L., Dominique Laroche, John D. Thurn, et al. "Tryptase Levels Are Not Increased during Vancomycin-induced Anaphylactoid Reactions." Anesthesiology 89, no. 3 (1998): 620–25. http://dx.doi.org/10.1097/00000542-199809000-00010.

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Background Anaphylaxis, mediated by immunoglobulin E, may be clinically indistinguishable but is mechanistically different than chemically mediated anaphylactoid reactions induced by drugs such as morphine, curare, and vancomycin. A test to distinguish anaphylactic from anaphylactoid reactions would clarify therapeutic and medicolegal issues. Tryptase levels identify anaphylactic reactions but have not been evaluated in vivo during anaphylactoid reactions. A prospective, randomized, double-blinded, placebo-controlled trial of antihistamine chemoprophylaxis for rapid vancomycin infusion was per

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Centanni, S., and P. Santus. "The Role of Antihistamine Drugs in Allergic Disorders." Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents 2, no. 3 (2003): 284–95. http://dx.doi.org/10.2174/1568014033483743.

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Sutherland, David C. "Antihistamine agents: new options or just more drugs?" Medical Journal of Australia 151, no. 3 (1989): 158–62. http://dx.doi.org/10.5694/j.1326-5377.1989.tb139603.x.

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Spasov, A. A., M. V. Chernikov, V. A. Anisimova, T. A. Kuz’menko, and M. M. Osipova. "Search for antihistamine drugs among imidazobenzimidazoles and triazolobenzimidazoles." Pharmaceutical Chemistry Journal 34, no. 2 (2000): 48–52. http://dx.doi.org/10.1007/bf02524356.

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Upasana, Khatri, Saini Sunil, and Bharkatiya Meenakshi. "Levo Cetirizine - the Drug with Numerous Plus to Cure Allergic Syndrome Compared to other Treatment Systems." Journal of Pharmaceutical Research 21, no. 4 (2022): 105–13. http://dx.doi.org/10.18579/jopcr/v21i4.ms221204.

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Many drugs are available to treat allergic condition. This review focused on why antihistaminics are best choice for treatment of allergic disorder especially allergic rhinitis (AR). AR is a chronic inflammatory disease. AR can be detected by its characteristics of nasal congestion, nasal itching, sneezing, rhinorrhoea, pruritis, redness, tearing and itching of eyes. This is very common and increases day after day. Allergic rhinitis is not lethal but interferes with daily schedule in a sustained manner. It is also observed that after COVID-19, stimuli reactions such as allergic condition, brea

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Gushchin, Igor S., and Ekaterina N. Medunitsyn. "Bilastine as a modern antihistamine for the treatment of allergic rhinitis and urticaria." Russian Journal of Allergy 17, no. 1 (2020): 93–100. http://dx.doi.org/10.36691/raj.2020.17.1.010.

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Antihistamines have long been an integral part of the treatment of allergic rhinitis and urticaria. Treatment of these diseases is usually long-term, so the drugs of choice are H1-antihistamines of the second generation, which have high efficiency and a good safety profile in the absence of clinically significant side effects. The variety of drugs in this group makes it possible to personalize the therapy, using the drug taking into account the individual sensitivity of the patient. One of the antihistamines used in practical allergy at the present time is bilastine. The article presents the d

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Nochaiwong, Surapon, Mati Chuamanochan, Chidchanok Ruengorn, and Kednapa Thavorn. "Evidence Gaps in Clinical Trials of Pharmacologic Treatment for H1-Antihistamine-Refractory Chronic Spontaneous Urticaria: A Systematic Review and Future Perspectives." Pharmaceuticals 15, no. 10 (2022): 1246. http://dx.doi.org/10.3390/ph15101246.

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No data addressing issues concerning disparities in participant and trial characteristics and trial outcome reporting have been established in clinical trials for H1-antihistamine-refractory chronic spontaneous urticaria (CSU). To better harmonize and compare the different treatment interventions, we systematically evaluated the overall landscape of pharmacological treatments for H1-antihistamine-refractory CSU clinical trials published between 2000 and 2021. This systematic review included 23 randomized clinical trials involving 2480 participants from 22 countries. We found significant increa

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Tandra, Gabriella, Amy Yoone, Rhea Mathew, Minzhi Wang, Chadwick M. Hales, and Cassie S. Mitchell. "Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson’s Disease." International Journal of Molecular Sciences 24, no. 15 (2023): 12339. http://dx.doi.org/10.3390/ijms241512339.

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Parkinson’s disease (PD) is a movement disorder caused by a dopamine deficit in the brain. Current therapies primarily focus on dopamine modulators or replacements, such as levodopa. Although dopamine replacement can help alleviate PD symptoms, therapies targeting the underlying neurodegenerative process are limited. The study objective was to use artificial intelligence to rank the most promising repurposed drug candidates for PD. Natural language processing (NLP) techniques were used to extract text relationships from 33+ million biomedical journal articles from PubMed and map relationships

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Nikiforova, G. N., V. M. Svistushkin, and A. V. Zolotova. "Allergic rhinitis. Modern opportunities of pathogenetic therapy." Medical Council, no. 8 (April 18, 2019): 83–88. http://dx.doi.org/10.21518/2079-701x-2019-8-83-88.

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Allergic rhinitis is a global public health problem at the present stage, given the high prevalence, the formation of therapy-resistant phenotypes, high comorbidity and the negative impact on all aspects of a patient’s life. Histamine is one of the main mediators of allergy, and therefore drugs number one in the treatment of patients with AR of all options are antihistamine drugs or H1-blockers. The innovative antihistamine drug of the second generation levocetirizine (Allerway®) prevents the development and facilitates the course of allergic reactions, also has anti-inflammatory and antialler

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José de Abajo, Francisco, and Luis Alberto García Rodríguez. "Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs." British Journal of Clinical Pharmacology 47, no. 3 (1999): 307–13. http://dx.doi.org/10.1046/j.1365-2125.1999.00885.x.

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Poirier, Judes, Madeleine Roy, Giuseppe Campanella, Thérèse Cloutier, and Suzanne Paris. "DEBRISOQUINE METABOLISM IN PARKINSONIAN PATIENTS TREATED WITH ANTIHISTAMINE DRUGS." Lancet 330, no. 8555 (1987): 386. http://dx.doi.org/10.1016/s0140-6736(87)92396-8.

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Wolff, S. C., K. Brubaker, T. Navratil, E. H. Fulcher, J. R. Lankford, and J. L. Boyer. "Anticholinergic Effects of Antihistamine Drugs Used in the Clinic." Journal of Allergy and Clinical Immunology 119, no. 1 (2007): S153. http://dx.doi.org/10.1016/j.jaci.2006.11.535.

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Wesselhøft, R., L. Rasmussen, P. Jensen, et al. "Use of hypnotic drugs among Scandinavian children, adolescents, and young adults." European Psychiatry 65, S1 (2022): S82—S83. http://dx.doi.org/10.1192/j.eurpsy.2022.250.

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Introduction Hypnotic drug use in children and adolescents is widely debated. Objectives To describe use of hypnotic drugs (melatonin, z-drugs and sedating antihistamines) among 5-24-year-old Scandinavians during 2012 to 2018. Methods Aggregate-level data from public data sources in Sweden, Norway and Denmark. We calculated annual prevalence (users/1000 inhabitants) stratified by sex, age group and country. Quantity of use (Defined Daily Dose (DDD)/user/day) was estimated for Norway and Denmark. Results Melatonin was most frequently used, with an increase from 2012 to 2018 in all countries. Sw

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Iakovlieva, L. V., O. G. Berdnik, and A. A. Gurtyakova. "Analysis of assortment and volumes of consumption of antihistamin preparations in Ukraine." Farmatsevtychnyi zhurnal, no. 1-2 (August 14, 2018): 12–21. http://dx.doi.org/10.32352/0367-3057.1-2.18.02.

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Over the past 30 years, the prevalence of allergic diseases has doubled every 10 years. According to WHO, currently about 5% of the world's adult population and 15% of children suffer from allergic diseases. The purpose of the study is to analyze the assortment of antihistamines in the pharmaceutical market of Ukraine, determine the availability for consumers by the indicator of Ca.s. and their volumes of consumption by ATS/DDD-methodology during 2014‒2017. Represented in the pharmaceutical market of Ukraine antihistamines were analyzed according to the analytical system of researc

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Zakeri, Mina, Majid Monajjemi, and Ali Ebrahimi. "Thermodynamic investigation of promethazine, loratadine, cetirizine and buclizine as antihistamine drugs; monte carlo and semi-empirical studies." Nexo Revista Científica 33, no. 01 (2020): 94–108. http://dx.doi.org/10.5377/nexo.v33i01.10050.

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In this article, we discussed about four antihistamine drug called promethazine, loratadine, cetirizine and buclizine. Promethazine in this list is the only one in first generation antihistamine classification with CNS sedation effect and the other three belongs to second generation antihistamine group which are non-sedation and used to treat in many different anti-allergenic fields. In the following we optimized potential, kinetic and total energy of these molecules at body temperature (310 k˚) and environment temperature (298 k ˚) using Mont Carlo method in Amber force field in 500 ns. The q

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Gelfand, Erwin W. "Pediatric Allergic Rhinitis: Factors Affecting Treatment Choice." Ear, Nose & Throat Journal 84, no. 3 (2005): 163–68. http://dx.doi.org/10.1177/014556130508400314.

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Allergic rhinitis is the most prevalent chronic allergic disease in children. Although it is not life-threatening, it can have a significantly detrimental effect on a child's quality of life, and it may exacerbate a number of common comorbidities, including asthma and sinusitis. The Allergic Rhinitis and its Impact on Asthma guidelines, an evidence-based algorithm for the treatment of allergic rhinitis, advocate the use of antihistamines for the treatment of the broad spectrum of the disease. However, first-generation antihistamines are associated with a number of adverse events, including cen

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Nucera, Eleonora, Riccardo Inchingolo, Rosario Nicotra, et al. "Influence of Antihistamines on Basophil Activation Test in Food Allergy to Milk and Egg." Diagnostics 11, no. 1 (2020): 44. http://dx.doi.org/10.3390/diagnostics11010044.

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Background: The basophil activation test (BAT) is used to improve the accuracy of food allergy diagnosis. To date, the influence of antiallergic drugs on BAT reactivity is poorly investigated. The aim of the study was to investigate if BAT results were influenced by antihistamine intake for 3 months in a cohort of patients with IgE-mediated food allergy to milk or egg. Methods: A retrospective, single-center, observational study was performed. We enrolled subjects with history of hypersensitivity reaction after specific food ingestion, positive skin prick tests and specific IgEs, concomitant a

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Krivopalov, A. A., S. A. Rebrova, and P. A. Shamkina. "Features of the modern antihistamines use in the treatment of allergic rhinitis." Meditsinskiy sovet = Medical Council, no. 12 (September 19, 2021): 101–8. http://dx.doi.org/10.21518/2079-701x-2021-12-101-108.

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Allergic rhinitis remains one of the most relevant problems of modern otorhinolaryngology. The widespread prevalence, late diagnosis, underestimation of the possible risks of disease progression, the development of complications (including asthma) prompts the development and improvement of new treatment options for allergic rhinitis. Allergic rhinitis is a heterogeneous disease that presents with various clinical phenotypes, and therefore the severity of nasal symptoms can vary from mild malaise to severe disease.. Today, pharmacotherapy remains the most frequently used treatment tactic for pa

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Murashkin, N. N., M. I. Gluzmin, A. I. Materikin, N. N. Murashkin, M. I. Gluzmin, and A. I. Materi kin. "Assessment of the efficacy of antihistamine drugs in complex treatment of chronic itchingdermatoses." Vestnik dermatologii i venerologii 87, no. 4 (2011): 84–87. http://dx.doi.org/10.25208/vdv1050.

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The authors give a review of current concepts of mechanisms of skin itching development for different types of chronic dermatoses. The authors also present the results of a study aimed at assessing the efficacy of different 2nd generation antihistamine drugs used for complex treatment of 83 patients aged 14-73 suffering from different chronic itching dermatoses (atopic dermatitis, eczema, pruritus, chronic urticaria, progressing psoriasis, lichen acuminatus, contact allergic dermatitis). The authors conclude that Glencet (levocetirizine) used in a complex therapy of dermatoses accompanied with

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Källén, B. "Use of antihistamine drugs in early pregnancy and delivery outcome." Journal of Maternal-Fetal & Neonatal Medicine 11, no. 3 (2002): 146–52. http://dx.doi.org/10.1080/jmf.11.3.146.152.

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BROOKS, C., and K. KARL. "Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs." Journal of Allergy and Clinical Immunology 81, no. 6 (1988): 1110–17. http://dx.doi.org/10.1016/0091-6749(88)90877-9.

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Rawlings, Clarence A., and Randall L. Tackett. "Postadulticide pulmonary hypertension of canine heartworm disease: Successful treatment with oxygen and failure of antihistamines." American Journal of Veterinary Research 51, no. 10 (1990): 1565–69. http://dx.doi.org/10.2460/ajvr.1990.51.10.1565.

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SUMMARY Postadulticide pulmonary hypertension mechanisms and treatment with antihistamines and supplemental oxygen were studied in eight dogs with heartworm disease. To ensure severe postadulticide thromboembolism, additional heartworms (either 20 or 40 into 4 dogs each) were transplanted into naturally infected dogs before thiacetarsamide treatment. During pentobarbital anesthesia, 2 pulmonary hemodynamic studies were conducted on each dog with a sequence of baseline, hypoxia with FlO2 = 10%, hyperoxia with FlO2 = 100%, a second baseline, treatment with either diphenhydramine (D) or cimetidin

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Luss, L. V. "Fenkarol - the first nonsedative antihistamine for parenteral administration." Russian Journal of Allergy 12, no. 1 (2015): 54–59. http://dx.doi.org/10.36691/rja491.

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In the pathogenesis of various diseases histamine performs an important role relating to one of the most important mediators involved in the regulation of vital functions in the body. Histamine plays a key role in the development of allergic diseases and pseudoallergic reactions. Therefore, in clinical practice, of particular interest are drugs that block the effects of histamine - antihistamines. The lecture highlights mechanisms of action of histamine and indications for antihistamines. Particular attention is given to parenteral forms of antihistamines and benefits of a new form of antihist

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Amina Mumtaz, Amina Mumtaz, and Sajjad ul Hassan and Shafaq Mubarak Sajjad ul Hassan and Shafaq Mubarak. "Development and Optimization of Green Method for Antihistamine Using Ecofriendly Reagent in Pure and Pharmaceutical Formulations by Microwave Assisted Spectrophotometry." Journal of the chemical society of pakistan 41, no. 6 (2019): 1028. http://dx.doi.org/10.52568/000810/jcsp/41.06.2019.

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Synthetic substances and solvents utilized in investigation of drugs crumble the earth as well as human health. So attempts should be made to minimize or eliminate the utilization of obnoxious chemicals and solvents. The objective of study is to develop the green spectroscopic method using new ecofriendly chromogenic reagent for the evaluation of antihistamine i.e. desloratadine in pure and commercial dosage forms. Both heating systems (conventional and microwave assisted procedures) are used for the development of color. The method is based on formation of stable blue coloured complex with am

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Ren, Ee Chee, Nicole Ziyi Zhuo, Zhi Yi Goh, Isabelle Bonne, Benoît Malleret, and Hui Ling Ko. "cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels." Biomolecules 13, no. 10 (2023): 1438. http://dx.doi.org/10.3390/biom13101438.

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Chronic infection with hepatitis B virus (HBV) is incurable, as the current therapeutics cannot eliminate its persistent genomic material, cccDNA. Screening systems for cccDNA-targeting therapeutics are unavailable, as low copies of cccDNA in vitro complicate detection. To address this, cccDNA copies were massively increased to levels detectable via automated plate readers. This was achieved via continuous infection in a contact-free co-culture of an HBV generator (clone F881), which stably produced clinically relevant amounts of HBV, and HBV acceptors selected to carry high cccDNA loads. cccD

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Shafee, Ur Rehman. "Assessment of physician knowledge and prescribing practices regarding antihistamine agents in the management of allergic conditions: A survey study in Kyrgyzstan." International Journal of Biosciences (IJB) 25, no. 6 (2024): 292–98. https://doi.org/10.12692/ijb/25.6.292-298.

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Antihistamines are a class of drugs commonly used to treat symptoms of allergies. Even over-the-counter allergy medications have side effects, and some allergy medications can cause problems when combined with other medications. Hence the Physician needs to choose the most effective allergy medications and avoid problems. Hence the current study was conducted to assess the knowledge and prescribing practices of physicians regarding antihistamine agents for the management of allergic conditions. A survey-based approach was employed to gather data from physicians across various specialties in Ky

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Muñoz-Cano, Rosa M., Rocio Casas-Saucedo, Antonio Valero Santiago, Irina Bobolea, Paula Ribó, and Joaquim Mullol. "Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications." Journal of Clinical Medicine 8, no. 9 (2019): 1338. http://dx.doi.org/10.3390/jcm8091338.

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Platelet-activating factor (PAF) is a lipid mediator involved in several allergic reactions. It is released from multiple cells of the immune system, such as eosinophils, neutrophils, and mast cells, and also exerts its effect on most of them upon specific binding to its receptor, becoming a pleiotropic mediator. PAF is considered a potential relevant mediator in allergic rhinitis, with a key role in nasal congestion and rhinorrhoea due to its effect on vascular permeability. Interestingly, despite its potential relevance as a therapeutic target, no specific PAF inhibitors have been studied in

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Oh, Ki-Kwang, Md Adnan, and Dong-Ha Cho. "Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19." Current Issues in Molecular Biology 44, no. 4 (2022): 1597–609. http://dx.doi.org/10.3390/cimb44040109.

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Antihistamines have potent efficacy to alleviate COVID-19 (Coronavirus disease 2019) symptoms such as anti-inflammation and as a pain reliever. However, the pharmacological mechanism(s), key target(s), and drug(s) are not documented well against COVID-19. Thus, we investigated to decipher the most significant components and how its research methodology was utilized by network pharmacology. The list of 32 common antihistamines on the market were retrieved via drug browsing databases. The targets associated with the selected antihistamines and the targets that responded to COVID-19 infection wer

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Sadykov, B. G. "Experience of using citral in combination with nonspecific drugs for Rh and ABO incompatible pregnancies." Kazan medical journal 43, no. 4 (2021): 47–49. http://dx.doi.org/10.17816/kazmj87207.

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To prevent hemolytic disease of the newborn (HDN) in Rh and ABO incompatible pregnancies, effective desensitizing treatment is required. For this purpose, various means and methods have been proposed and tested. Among them are antihistamine drugs, namely antistin, citral (L. Girshfeld, T. G. Solovyova, I. A. Vasilyeva).

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Kast, Richard E., Marc-Eric Halatsch, and Rafael Rosell. "OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs." Cells 10, no. 5 (2021): 1148. http://dx.doi.org/10.3390/cells10051148.

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Background: Pharmacological targeting aberrant activation of epidermal growth factor receptor tyrosine kinase signaling is an established approach to treating lung adenocarcinoma. Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor. The emergence of resistance to osimertinib after a year or two is the rule. We developed a five-drug adjuvant regimen designed to increase osimertinib’s growth inhibition and thereby delay the development of resistance. Areas of Uncertainty:

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Martínez-Algaba, C., J. M. Bermúdez-Saldaña, R. M. Villanueva-Camañas, S. Sagrado, and M. J. Medina-Hernández. "Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography." Journal of Pharmaceutical and Biomedical Analysis 40, no. 2 (2006): 312–21. http://dx.doi.org/10.1016/j.jpba.2005.07.037.

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