Academic literature on the topic 'Antihyperglycemia'

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Journal articles on the topic "Antihyperglycemia"

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Faroliu, Goldha, and Cici Adelia. "Uji Efektivitas Antihiperglikemia Ekstrak Daun Puring (Codiaeum variegatum) Terhadap Mencit Jantan (Mus musculus L.)." JFARM - Jurnal Farmasi 2, no. 2 (2024): 63–72. https://doi.org/10.58794/jfarm.v2i2.962.

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Diabetes mellitus (DM) is a metabolic disease due to insulin secretion disorders due to pancreatic cell damage. Puring plants (Codiaeum variegatum) in Indonesia are more identical as cemetery plants and garden decorations. The purpose of this study was to see the antihyperglycemic effect of croton leaf extract. This study was conducted by making croton leaf extract, phytochemical screening, and antihyperglycemia testing by observing the decrease in blood glucose levels in mice induced by alloxan. Based on the results of phytochemical tests, croton leaves contain compounds such as flavonoids, t
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Hidayat, Rachmat, Lusia Hayati, and Nita Parisa. "Indonesian plants with potential as an anti-diabetes mellitus agent." Eureka Herba Indonesia 1, no. 2 (2020): 28–31. http://dx.doi.org/10.37275/ehi.v1i2.7.

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Diabetes Mellitus (DM) is a degenerative disease that continues to increase in numberin Indonesia and is a disease that is spread throughout the world due to unbalancednutritional conditions. Treatment of diabetes mellitus is a chronic and lifelongtreatment. Treatment of diabetes mellitus, such as the use of insulin and oralantihyperglycemia drugs, is relatively expensive, is used for a long time and can causeunwanted side effects. There are many plants that have potential as antihyperglycemiadrugs. One of the active compounds that act as antihyperglycemia isflavonoids.Flavonoids derived from
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Sasiarini, Laksmi, Charisma Dian Simatupang, and Putu Moda Arsana. "Correlation between Risk Stratification of Complications and Types of Antihyperglycemia Drugs with Incidence of Acute Diabetic Complications in Patients with Diabetes Mellitus during Ramadan Fasting." Clinical and Research Journal in Internal Medicine 1, no. 2 (2020): 69–78. http://dx.doi.org/10.21776/ub.crjim.2020.001.02.3.

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Ramadan fasting for Diabetes Mellitus (DM) patients can lead to acute complications such as hypoglycemia, hyperglycemia, diabetic ketoacidosis (DKA) and thrombosis. Risk stratification predicts fasting safety of DM patients. Dose and timing of antihyperglycemia drugs adjusted during Ramadan fasting. Aim: To know the correlation between the risk stratification of Ramadan fasting and type of antihyperglycemia drugs with the incidence of acute complications in DM patients undergoing Ramadan fasting. Methods: DM patients in Endocrinology Clinic, dr. Saiful Anwar, General Hospital Malang who intend
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Rahmi, Sofia, Rosidah, Tri Widyawati, and Sumaiyah. "Utilization of tekelan leaf extract (Chromolaena odorata L.) based on nanoliposome technology as treatment of antihyperglycemia." E3S Web of Conferences 332 (2021): 01007. http://dx.doi.org/10.1051/e3sconf/202133201007.

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Metabolic disease that occurs due to abnormalities in insulin secretion and insulin action is said to be diabetes or hyperglycemia. One alternative that can be used for hyperglycemia management is to use tekelan leaves (C. odorata L.). The leaves of this tekelan plant have low water solubility and high permeability. A liposome is a good carrier to increase the solubility and penetration of the compounds it carries. This study aimed to develop a nanotechnological liposomal preparation from the ethanol extract of tekelan leaves as a hypoglycemic agent in diabetic male rats induced by nicotinamid
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Konaté, Kiessoun, Kassi Yomalan, Oksana Sytar, et al. "Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves ofTrichilia emeticaandOpilia amentaceain an Animal Model of Type 2 Diabetes Mellitus." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/867075.

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Trichilia emeticaandOpilia amentaceatraditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes.In vitroandin vivoantioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves ofTrichilia emeticaandOpilia amentaceahas been evaluated usingβ-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl
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Nurlaili, Jasril, and Hilwan Yuda Teruna. "UJI AKTIVITAS ANTIOKSIDAN SENYAWA PIRAZOLIN 3-(2- METOKSI-FENIL)-5-NAFTALEN-1-IL-4,5-DIHIDRO-1H-PIRAZOL." Photon: Jurnal Sain dan Kesehatan 8, no. 2 (2018): 53–58. http://dx.doi.org/10.37859/jp.v8i2.716.

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Pyrazoline compounds are reported to have many useful biological activities such as antimicrobials, antihyperglycemia, antioxidants, anti-inflammatory, anticancer and anticonvulsants. The pyrazoline analogues of 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-4,5-dihydro-1H-pyrazol were synthesized usingglacial acetic acid as catalyst and assisted by microwave irradiation. The structures of the compounds were obtainedby UV, IR and HRMS spectroscopy data. Antioxidant activity test using DPPH method showed that pyrazoline compound had IC50 value of 27.41 μg/mL.
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Nguyen, Hoang Sa, Ha Thanh Nguyen, Van Loc Tran, et al. "Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage." Hue University Journal of Science: Natural Science 132, no. 1B (2023): 43–47. http://dx.doi.org/10.26459/hueunijns.v132i1b.6810.

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Betulinic acid derivatives exhibit different biological activity against diversified targets, such as anticarcinogenic activity in experimental animals, anti-HIV, antihyperglycemia, and anti-inflammatory in humans. In this work, we investigated the synthetic procedure of 24-nor-3-oxo-20(29)-lupen-28-oic acid (1) derivatives. Starting from compound 1 and L-leucine methyl ester, we proceeded with amidification, reduction, and hydrolysis under basic conditions. Finally, three hybrid compounds were successfully synthesised and elucidated with spectral means.
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Park, Keum-Ju, Hwi-Seung Jin, Seung-Hee Park, Eun-Ho Kim, and Jae-Ki Kim. "Antihyperglycemia Effect of Medicinal Plants Mixture in Streptozotocin-Induced Diabetic Rats." Journal of the Korean Society of Food Science and Nutrition 37, no. 12 (2008): 1554–59. http://dx.doi.org/10.3746/jkfn.2008.37.12.1554.

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Kim, Ji Eun, Ji Yeon Lee, and Chang-Ho Kang. "Limosilactobacillus fermentum MG4295 Improves Hyperglycemia in High-Fat Diet-Induced Mice." Foods 11, no. 2 (2022): 231. http://dx.doi.org/10.3390/foods11020231.

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Hyperglycemia due to uncontrolled glucose regulation is widely known as cause of diabetes, non-alcoholic fatty liver disease (NAFLD), and other complications. NAFLD refers to a condition in which fat is excessively accumulated, whether inflamed or not, and has caused serious medical problems in recent years. The aim of this study was to explore the antihyperglycemia effects of Limosilactobacillus fermentum MG4295 (L. fermentum MG4295) in high-fat diet (HFD)-induced in vivo. We demonstrated the suitability of L. fermentum MG4295 as a probiotic by observing its stability, survivability, and prol
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Susanti, Try, Dwi Gusfarenie, and Nining Nuraida. "Uji Efektifitas Ekstrak Daun Sirih Merah sebagai Anti Hiperglikemia pada Tikus Putih Diinduksi Aloksan." Bioscientist : Jurnal Ilmiah Biologi 12, no. 1 (2024): 453. http://dx.doi.org/10.33394/bioscientist.v12i1.10427.

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Diabetes melitus or diabetes is a health disorder in the form of a collection of symptoms that arise in a person caused by increased blood sugar leves due to insulin deficiency or insulin resistance and metabolic disorders in general. Red bete leaves contain chemical compounds of alkaloids, flavonoids, tannins and saponins which can lower blood sugar leves. The aim of this study was to determine the effectiveness of red bete leaf extract suspension (Piper crocatum) as antihyperglycemia in male white rats (Rattus novergicus) induced by alloxan. This research method is experimental. The extracti
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Dissertations / Theses on the topic "Antihyperglycemia"

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MacKinnon, Lindsay M. "Self-adjusting doses of oral antihyperglycemic therapy using repaglinide or glyburide in type 2 diabetes : the soaring study." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98758.

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Cette etude pilote de six mois examinait si l'autogestion (AG) intensive par un agent secreteur d'insuline avait pour consequence une glycemie amelioree en comparaison avec une gestion standard (GS) chez les individus atteints de diabete de type 2. Des patients ont ete randomises soit a l'AG avec du repaglinide (n=8), ou du glyburide (n=6) ou a la GS (n=5). Des analyses biochimiques, alimentaires, comportementales, et d'activite physique ont ete effectuees. Les deux groupes de l'AG ont recu un enseignement d'autogestion en fonction du taux de glucose sanguin et une evaluation nutritionnelle qu
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PELE, TOUNIAN AGNES. "Etude pharmacologique et mecanistique chez le rat d'un derive imidazolinique antihyperglycemiant le s-22068 (pms 847)." Paris 7, 1998. http://www.theses.fr/1998PA077123.

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Le s-22068, un nouveau compose imidazolinique, s'est recemment avere tres efficace pour ameliorer la tolerance au glucose dans un modele experimental de rat fonde sur l'injection d'une faible dose de streptozotocine (35 mg/kg). Nous avons recherche les mecanismes d'action possibles a l'origine de son effet antihyperglycemiant. En utilisant la technique de perifusion d'ilots isoles nous avons retrouve, in vitro, la legere augmentation de la secretion d'insuline prealablement observee in vivo. Cette augmentation s'explique en partie par la capacite du s-22068 a induire directement la fermeture d
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Almarhoon, Zahra M. B. S. "Geographic Variation in the Utilization of Antihyperglycemic Therapies in the U.S. Medicaid Program at State-Level Using Geographic Information System." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553618550167677.

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Bartmus, Thomas. "A systematic review and mixed treatment comparison assessing the comparative effectiveness and safety of oral antihyperglycemic drugs as monotherapy in patients with type 2 diabetes mellitus." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171555.

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Bartmus, Thomas [Verfasser], and Ulrich [Akademischer Betreuer] Mansmann. "A systematic review and mixed treatment comparison assessing the comparative effectiveness and safety of oral antihyperglycemic drugs as monotherapy in patients with type 2 diabetes mellitus / Thomas Bartmus. Betreuer: Ulrich Mansmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/105807671X/34.

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Alsadeg, Aborus Naji Elhadi. "Fitohemijske i funkcionalne karakteristike praškastih formi klijanaca pšenice, ovsa i ječma." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2017. http://www.cris.uns.ac.rs/record.jsf?recordId=104607&source=NDLTD&language=en.

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U radu su ispitani fitohemijski profil, antioksida-tivna i in vitro biološka aktivnost ekstrakata klijanaca šest sorti žitarica: pšenica Spelt, Simonida, (WSSPE, WSSIM) ječam, hibrid “NS565” (Hordeum vulgare L. ssp distichum.) (BSNS) i ne-hibridni “Golozrni” (Hordeum vul-gare var nudum.) (BSG) i ovas Golozrni, Jadar (OSG, OSJ). U cilju poređenja šest istraživanih vrsta klijanaca ispitivanja su obuhvatila određivanje TPC, TFC, TChl, Chla, Chlb i TCX vrednosti i testiranje njihove biološke aktivnosti (antioksidativnog kapaciteta, redukci
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Aleksandra, Gavarić. "Savremene metode ekstrakcije očajnice (Marrubium vulgare L.) i sušenje odabranih ekstrakata, hemijski sastav i biološke aktivnosti." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114456&source=NDLTD&language=en.

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U okviru ove disertacije ispitane su mogućnosti primene savremenih metoda za dobijanje tečnih ekstrakata (ultrazvučna ekstrakcija, mikrotalasna ekstrakcija i ekstrakcija subkritičnom vodom) i lipofilnih ekstrakata (ekstrakcija superkritičnim ugljendioksidom) bogatih polifenolima iz nadzemnog dela očajnice (Marrubium vulgare L.). Tečni ekstrakti su optimizovani primenom eksperimentalnog dizajna i metode odzivne površine, i podvrgnuti su spray drying tehnici sušenja. Tečni i suvi ekstrakti su detaljno ispitani po pitanju hemijskog sastava i biološke aktivnosti, antimikrobne
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Miodrag, Jazić. "Hemijski sastav i biološki potencijal ploda, soka i tropa kultivisane i divlje kupine (Rubus fruticosus L.)." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=111236&source=NDLTD&language=en.

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U okviru ove disertacije ispitan je hemijski, mineralni ipolifenolni sastav, kao i biološki potencijal četiri sortekupina sa dva različita lokaliteta sjeverozapadnog dijelaBosne i Hercegovine, sa lokaliteta Verići (divlja ikultivisana sorta Čačanska bestrna) i sa lokalitetaJavorani (divlja sorta i kultivisana sorta ChesterThornles). Određen je sadržaj suve materije, pepela,sirove celuloze, ukupnih šećera, ukupna kiselost i sadržajaskorbinske kiseline. Sadržaj mineralnih materijadetektovan je metodom optičke emisione spektrometrije(ICP-OES). Za izdvajanje ekstrakata je kori&scaron
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Niu, Ho-Shan, and 牛河山. "Antihyperglycemic action of syringin." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/05019971685134411930.

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博士<br>臺北醫學大學<br>藥學系(博士班)<br>98<br>In streptozotocin-induced diabetic rats (STZ-diabetic rats), the type-1 diabetes-like animal model, the mechanism(s) of antihyperglycemic action produced by syringin, an active principle purified from the rhizome part of Eleutherococcus senticosus (Araliaceae),was investigated . Bolus intravenous (i.v.) injection of syringin for 30 min dose-dependently decreased the plasma glucose of STZ-diabetic rats in a way parallel to the increase of plasma ??-endorphin-like immunoreactivity (BER). Syringin enhanced BER release from the isolated adrenal medulla of STZ-diab
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Ke, Ya-Fang, and 柯雅芳. "Antihyperglycemic Action of Catalpol." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/96111222974348780639.

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碩士<br>國立成功大學<br>藥理學研究所<br>91<br>Catalpol, a monoterpene compound ,was isolated from “Die-Huang”. Catalpol produced a dose-dependent hypoglycemic action in streptozotocin -induced diabetic rats after an intravenous injection (i.v.). Catalpol at the effective dose (0.1mg/kg) significantly attenuated the increase of plasma glucose induced by intravenous glucose challenge test in Wistar rats. In vitro, catalpol enhanced the uptake of 14C 2-deoxy-glucose (2-DG) into skeletal muscle in a concentration-dependent manner. In the hepatocytes isolated from diabetic rats, catalpol also increased the synth
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Book chapters on the topic "Antihyperglycemia"

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Sahin, Ali. "Insulin-Sensitizing Antihyperglycemic Drugs." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.10.

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Insulin-sensitizing antihyperglycemic drugs are a class of medications used in the management of diabetes mellitus, particularly type 2 diabetes, by improving the body’s response to insulin. One prominent group within this category is the thiazolidinediones (TZDs), which include drugs like pioglitazone and rosiglitazone. These medications act primarily by activating peroxisome proliferator-activated receptor gamma (PPARγ) receptors, which play a key role in regulating glucose and lipid metabolism. By enhancing insulin sensitivity in peripheral tissues such as muscle, adipose tissue, and liver,
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Firdaus, Muhamad, Rahmi Nurdiani, and Asep A. Prihanto. "Antihyperglycemic of Sargassum sp. Extract." In Marine Algae Extracts. Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527679577.ch24.

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Shrivastava, Deepak. "Deprescribing Antihyperglycemics Injectable Agents (Insulins)." In Talking Points on Deprescribing in Hospice Care. CRC Press, 2024. http://dx.doi.org/10.1201/9781003392149-16.

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Aashima and Deepshikha Gupta. "Impurity Profiling of Antihyperglycemic Drug-Sitagliptin." In Springer Proceedings in Materials. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-5169-3_1.

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Hasslacher, Christoph. "Reducing Progression of Diabetic Nephropathy by Antihyperglycemic Treatment." In Diabetes and Kidney Disease. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118494073.ch13.

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Sämann, Alexander, and Ulrich A. Müller. "Dosage of Antihyperglycemic Drugs in Patients with Renal Insufficiency." In Diabetes and Kidney Disease. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118494073.ch14.

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Balsells, Montserrat, Apolonia García-Patterson, and Rosa Corcoy. "Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy." In Textbook of Diabetes and Pregnancy, 4th ed. CRC Press, 2024. https://doi.org/10.1201/9781003355939-31.

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Badole, S. L., A. A. Zanwar, and S. L. Bodhankar. "Antihyperglycemic Potential of Secoisolaricinol Diglucoside." In Bioactive Food as Dietary Interventions for Diabetes. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-397153-1.00005-6.

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Abd Ghafar, Siti Aisyah, Muhammad Fahmi Yakop, Rohazila Mohamad Hanafiah, and Norsharina Ismail. "Antihypercholesterolemic and antihyperglycemic activity of Nigella sativa." In Biochemistry, Nutrition, and Therapeutics of Black Cumin Seed. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-90788-0.00003-2.

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Badole, Sachin L., Kalyani Y. Patil, and Vinod D. Rangari. "Antihyperglycemic Activity of Bioactive Compounds from Soybeans." In Glucose Intake and Utilization in Pre-Diabetes and Diabetes. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-800093-9.00018-1.

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Conference papers on the topic "Antihyperglycemia"

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Hayati, Farida, Lutfi Chabib, and Diah Dwi Darma. "Antihyperglycemia activity of self-nano emulsifying drug-delivery systems (SNEDDS) of Ipomoea reptans, Poir leaf ethanolic extract in zebrafish (Danio rerio)." In 2ND INTERNATIONAL CONFERENCE ON CHEMISTRY, CHEMICAL PROCESS AND ENGINEERING (IC3PE). Author(s), 2018. http://dx.doi.org/10.1063/1.5064986.

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Nakanishi, Deborah Ayumi Alves, Diego Armando Barbosa Aragão, and Claudio Eduardo Corrêa Teixeira. "Systematic review with meta-analysis on the use of antihyperglycemic agents as a preventive factor for cognitive losses in diabetic patients." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.711.

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Background: Blood glucose variations are generally associated with predisposition to the development of dementia in diabetes patients. And there is a controversy in the literature about whether the use of antihyperglycemic agents can(not) promote protective effects on cognition. Design and setting: we used a systematic review with meta-analysis to evaluate whether the evidence in the literature points to a protective or harmful effect of antihyperglycemic agents on cognition. Methods: PubMed, Science Direct and Scielo databases were used to collect articles in English, published between 2005 a
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Koteswara Rao, Nalamolu, Krupavaram Bethala, and Sreenivas Patro Sisinthy. "ANTIHYPERGLYCEMIC ACTIVITY OF ORTHOSIPHON STAMINEUS BENTH IN STREPTOZOTOCIN INDUCED DIABETIC RATS : Antihyperglycemic activity of Orhtosiphon stamineus Benth." In Annual International Conference on Pharmaceutical Sciences and Pharmacology. Global Science & Technology Forum (GSTF), 2013. http://dx.doi.org/10.5176/2345-783x_pharma13.25.

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Widyawati, Tri, Siti Syarifah, Muhammad Ichwan, Dwi Rita Anggraini, and Arlinda Sari Wahyuni. "Antihyperglycemic and Pancreatic Protective Effect of Squalene in Streptozotocin-induced Diabetic Rat." In 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0010045204830486.

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"Antihyperglycemic and antihyperlipidemic activeities of Nannochloropsis oculata microalgae in streptozotocin-induced diabetic rats." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.18.

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Biagtan, Mary Grace Santos. "031: PHARMACOECONOMIC EVALUATION OF ANTIHYPERGLYCEMIC TREATMENT UTILIZED BY PATIENTS IN BAGUIO CITY, PHILIPPINES." In Global Forum on Research and Innovation for Health 2015. British Medical Journal Publishing Group, 2015. http://dx.doi.org/10.1136/bmjopen-2015-forum2015abstracts.31.

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Akulkina, Larisa, Anastasia Schepalina, Victoria Sholomova, et al. "Association between type of antihyperglycemic therapy and COVID-19 outcomes in patients with type 2 DM." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa3653.

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Wu, Hongmei, Feng Xu, Junjie Hao, Ye Yang, and Xiangpei Wang. "Antihyperglycemic Activity of Banana (Musa nana Lour.) Peel and Its Active Ingredients in Alloxan-Induced Diabetic Mice." In 3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME 2015). Atlantis Press, 2015. http://dx.doi.org/10.2991/ic3me-15.2015.44.

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Wardani, Elly, Dwitiyanti, Sediarso, and Dwina Puspandiyah. "Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters." In 1st Muhammadiyah International Conference on Health and Pharmaceutical Development. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008240601330137.

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Musdja, Muhammad Yanis, Weldy Marison, and Ahmad Musir. "Antihyperglycemic Effect and Glucose Tolerance of Ethanol Extract the Rind of Jengkol (Pithecollobium jiringa Jack) in Diabetic Rats." In International Conference Recent Innovation. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0009941322452250.

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Reports on the topic "Antihyperglycemia"

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Yibchok-anun, Sirintorn, Sophon Roengsumran, and H. Hsu, Walter. Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.84.

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The aim of this study was to investigate the effects of zinc-free protein extract from bitter gourd fruit pulp on plasma glucose concentration and insulin responses in normal and STZ-induced diabetic rats. Furthermore, we investigated the direct effect of the MC protein extract on insulin and glucagons secretions from the perfused rat pancreas as well as glucose uptake in C2C12 rat myocytes and 3T3-L1 rat adipocytes. The protein from Thai bitter gourd (Momordica charantia) fruit pulp was extracted and studied for its hypoglycemic effect. Subcutaneous administration of the protein extract (5 an
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