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Journal articles on the topic 'Antihyperglycemia'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Faroliu, Goldha, and Cici Adelia. "Uji Efektivitas Antihiperglikemia Ekstrak Daun Puring (Codiaeum variegatum) Terhadap Mencit Jantan (Mus musculus L.)." JFARM - Jurnal Farmasi 2, no. 2 (2024): 63–72. https://doi.org/10.58794/jfarm.v2i2.962.

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Diabetes mellitus (DM) is a metabolic disease due to insulin secretion disorders due to pancreatic cell damage. Puring plants (Codiaeum variegatum) in Indonesia are more identical as cemetery plants and garden decorations. The purpose of this study was to see the antihyperglycemic effect of croton leaf extract. This study was conducted by making croton leaf extract, phytochemical screening, and antihyperglycemia testing by observing the decrease in blood glucose levels in mice induced by alloxan. Based on the results of phytochemical tests, croton leaves contain compounds such as flavonoids, t

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2

Hidayat, Rachmat, Lusia Hayati, and Nita Parisa. "Indonesian plants with potential as an anti-diabetes mellitus agent." Eureka Herba Indonesia 1, no. 2 (2020): 28–31. http://dx.doi.org/10.37275/ehi.v1i2.7.

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Diabetes Mellitus (DM) is a degenerative disease that continues to increase in numberin Indonesia and is a disease that is spread throughout the world due to unbalancednutritional conditions. Treatment of diabetes mellitus is a chronic and lifelongtreatment. Treatment of diabetes mellitus, such as the use of insulin and oralantihyperglycemia drugs, is relatively expensive, is used for a long time and can causeunwanted side effects. There are many plants that have potential as antihyperglycemiadrugs. One of the active compounds that act as antihyperglycemia isflavonoids.Flavonoids derived from

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3

Sasiarini, Laksmi, Charisma Dian Simatupang, and Putu Moda Arsana. "Correlation between Risk Stratification of Complications and Types of Antihyperglycemia Drugs with Incidence of Acute Diabetic Complications in Patients with Diabetes Mellitus during Ramadan Fasting." Clinical and Research Journal in Internal Medicine 1, no. 2 (2020): 69–78. http://dx.doi.org/10.21776/ub.crjim.2020.001.02.3.

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Ramadan fasting for Diabetes Mellitus (DM) patients can lead to acute complications such as hypoglycemia, hyperglycemia, diabetic ketoacidosis (DKA) and thrombosis. Risk stratification predicts fasting safety of DM patients. Dose and timing of antihyperglycemia drugs adjusted during Ramadan fasting. Aim: To know the correlation between the risk stratification of Ramadan fasting and type of antihyperglycemia drugs with the incidence of acute complications in DM patients undergoing Ramadan fasting. Methods: DM patients in Endocrinology Clinic, dr. Saiful Anwar, General Hospital Malang who intend

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4

Rahmi, Sofia, Rosidah, Tri Widyawati, and Sumaiyah. "Utilization of tekelan leaf extract (Chromolaena odorata L.) based on nanoliposome technology as treatment of antihyperglycemia." E3S Web of Conferences 332 (2021): 01007. http://dx.doi.org/10.1051/e3sconf/202133201007.

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Metabolic disease that occurs due to abnormalities in insulin secretion and insulin action is said to be diabetes or hyperglycemia. One alternative that can be used for hyperglycemia management is to use tekelan leaves (C. odorata L.). The leaves of this tekelan plant have low water solubility and high permeability. A liposome is a good carrier to increase the solubility and penetration of the compounds it carries. This study aimed to develop a nanotechnological liposomal preparation from the ethanol extract of tekelan leaves as a hypoglycemic agent in diabetic male rats induced by nicotinamid

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5

Konaté, Kiessoun, Kassi Yomalan, Oksana Sytar, et al. "Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves ofTrichilia emeticaandOpilia amentaceain an Animal Model of Type 2 Diabetes Mellitus." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/867075.

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Trichilia emeticaandOpilia amentaceatraditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes.In vitroandin vivoantioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves ofTrichilia emeticaandOpilia amentaceahas been evaluated usingβ-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl

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6

Nurlaili, Jasril, and Hilwan Yuda Teruna. "UJI AKTIVITAS ANTIOKSIDAN SENYAWA PIRAZOLIN 3-(2- METOKSI-FENIL)-5-NAFTALEN-1-IL-4,5-DIHIDRO-1H-PIRAZOL." Photon: Jurnal Sain dan Kesehatan 8, no. 2 (2018): 53–58. http://dx.doi.org/10.37859/jp.v8i2.716.

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Pyrazoline compounds are reported to have many useful biological activities such as antimicrobials, antihyperglycemia, antioxidants, anti-inflammatory, anticancer and anticonvulsants. The pyrazoline analogues of 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-4,5-dihydro-1H-pyrazol were synthesized usingglacial acetic acid as catalyst and assisted by microwave irradiation. The structures of the compounds were obtainedby UV, IR and HRMS spectroscopy data. Antioxidant activity test using DPPH method showed that pyrazoline compound had IC50 value of 27.41 μg/mL.

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7

Nguyen, Hoang Sa, Ha Thanh Nguyen, Van Loc Tran, et al. "Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage." Hue University Journal of Science: Natural Science 132, no. 1B (2023): 43–47. http://dx.doi.org/10.26459/hueunijns.v132i1b.6810.

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Betulinic acid derivatives exhibit different biological activity against diversified targets, such as anticarcinogenic activity in experimental animals, anti-HIV, antihyperglycemia, and anti-inflammatory in humans. In this work, we investigated the synthetic procedure of 24-nor-3-oxo-20(29)-lupen-28-oic acid (1) derivatives. Starting from compound 1 and L-leucine methyl ester, we proceeded with amidification, reduction, and hydrolysis under basic conditions. Finally, three hybrid compounds were successfully synthesised and elucidated with spectral means.

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8

Park, Keum-Ju, Hwi-Seung Jin, Seung-Hee Park, Eun-Ho Kim, and Jae-Ki Kim. "Antihyperglycemia Effect of Medicinal Plants Mixture in Streptozotocin-Induced Diabetic Rats." Journal of the Korean Society of Food Science and Nutrition 37, no. 12 (2008): 1554–59. http://dx.doi.org/10.3746/jkfn.2008.37.12.1554.

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9

Kim, Ji Eun, Ji Yeon Lee, and Chang-Ho Kang. "Limosilactobacillus fermentum MG4295 Improves Hyperglycemia in High-Fat Diet-Induced Mice." Foods 11, no. 2 (2022): 231. http://dx.doi.org/10.3390/foods11020231.

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Hyperglycemia due to uncontrolled glucose regulation is widely known as cause of diabetes, non-alcoholic fatty liver disease (NAFLD), and other complications. NAFLD refers to a condition in which fat is excessively accumulated, whether inflamed or not, and has caused serious medical problems in recent years. The aim of this study was to explore the antihyperglycemia effects of Limosilactobacillus fermentum MG4295 (L. fermentum MG4295) in high-fat diet (HFD)-induced in vivo. We demonstrated the suitability of L. fermentum MG4295 as a probiotic by observing its stability, survivability, and prol

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10

Susanti, Try, Dwi Gusfarenie, and Nining Nuraida. "Uji Efektifitas Ekstrak Daun Sirih Merah sebagai Anti Hiperglikemia pada Tikus Putih Diinduksi Aloksan." Bioscientist : Jurnal Ilmiah Biologi 12, no. 1 (2024): 453. http://dx.doi.org/10.33394/bioscientist.v12i1.10427.

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Diabetes melitus or diabetes is a health disorder in the form of a collection of symptoms that arise in a person caused by increased blood sugar leves due to insulin deficiency or insulin resistance and metabolic disorders in general. Red bete leaves contain chemical compounds of alkaloids, flavonoids, tannins and saponins which can lower blood sugar leves. The aim of this study was to determine the effectiveness of red bete leaf extract suspension (Piper crocatum) as antihyperglycemia in male white rats (Rattus novergicus) induced by alloxan. This research method is experimental. The extracti

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11

F.Al-Jumaily, Essam. "and antihyperglycemia effects of resvertrol and its derivative on alloxan diabetic rabbits." IOSR Journal of Pharmacy (IOSRPHR) 2, no. 4 (2012): 49–57. http://dx.doi.org/10.9790/3013-24104957.

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12

Pinto, Marcia Da Silva, Lena Galvez Ranilla, Emmanouil Apostolidis, Franco Maria Lajolo, Maria Inés Genovese, and Kalidas Shetty. "Evaluation of Antihyperglycemia and Antihypertension Potential of Native Peruvian Fruits UsingIn VitroModels." Journal of Medicinal Food 12, no. 2 (2009): 278–91. http://dx.doi.org/10.1089/jmf.2008.0113.

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13

Barbosa, Ana Cristina Lopes, Marcia da Silva Pinto, Dipayan Sarkar, Chandrakant Ankolekar, Duane Greene, and Kalidas Shetty. "Varietal Influences on Antihyperglycemia Properties of Freshly Harvested Apples UsingIn VitroAssay Models." Journal of Medicinal Food 13, no. 6 (2010): 1313–23. http://dx.doi.org/10.1089/jmf.2009.0273.

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14

Djohan, Djohan. "EFFECTIVENESS OF TOMATO (SOLANUM LYCOPERSICUM) NANOHERBAL AS ANTIHYPERGLYCEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RAT." Jambura Journal of Health Sciences and Research 4, no. 3 (2022): 859–68. http://dx.doi.org/10.35971/jjhsr.v4i3.13760.

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Diabetes merupakan penyakit kronis yang terjadi di saat insulin yang diproduksi oleh tubuh tidak bisa digunakan secara efektif maupun organ pankreas mengalami masalah dimana insulin tidak dapat diproduksi sebagaimana mestinya. Kebaruan penelitian ini karena meneliti tentang efektivitas nanoherbal tomat (solanum lycopersicum) sebagai antihiperglikemia pada tikus diabetes yang terinduksi streptozotocin. Penelitian ini bertujuan untuk secara sistematis menganalisis dan meninjau hewan dan penelitian pada tikus putih yang diinduksi STZ. Metode pencarian elektronik dilakukan dengan mencari MEDLINE m

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15

Djohan, Djohan, Bungaran Sihombing, Sahna Ferdinand, and Hanjaya Hanjaya. "The Effect Of Nanoherbal Solanum Lycopersicum On Rat Induced Streptozotocin." Proceedings of Malikussaleh International Conference on Health and Disaster Medicine (MICOHEDMED) 1 (October 7, 2022): 30–38. http://dx.doi.org/10.29103/micohedmed.v1i1.9.

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Abstract : Diabetes Mellitus (DM) has become a global health threat in the 21st century. DM sufferers are increasing, according to the International Diabetes Federation (IDF) in 2017, the number of DM sufferers in the world is 7.5 million people and is predicted to be 9.5 million in 2017. In 2045, Indonesia itself was ranked 7th out of 10 countries with the most DM at the age of 20-79 years and ranked 4th out of 10 countries with the largest population of undiagnosed. This study aim to determine the antihyperglycemia activity of Nanoherbal Extract of Solanum lycopersicum. This is an experiment

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16

Therasa, S. Viviyan, T. Thirumalai, N. Tamilselvan, and E. David. "In-vivo and ex-vivo inhibition of intestinal glucose uptake: A scope for antihyperglycemia." Journal of Acute Disease 3, no. 1 (2014): 36–40. http://dx.doi.org/10.1016/s2221-6189(14)60008-1.

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17

Satyanarayana, S., K. Eswar Kumar, and J. Raja Sekhar. "Effect of ?-lipoic acid on gliclazide-induced hypoglycemia/antihyperglycemia in normal/alloxan-induced diabetic rats." Therapy 3, no. 5 (2006): 613–17. http://dx.doi.org/10.1586/14750708.3.5.613.

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18

Daulay, Agus Husein, Jekson Martiar Siahaan, Lesmana Syahrir, and Ronald Tunggul Hotmarojahan Tambunan. "Effectiveness of Ethanol Extract and Ethyl Acetate Fraction of Breadfruit Leaves (Artocarpus altilis) as Antihyperglycemia." Indonesian Journal of Medicine 9, no. 3 (2024): 284–95. https://doi.org/10.26911/theijmed.2024.9.3.753.

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Background: The rising diabetes mellitus (DM) population is a public health concern. Pharmacotherapy for DM can cause side effects and is often inaccessible, necessitating alternative therapies like medicinal plants. Breadfruit leaves (Artocarpus altilis) have antidiabetic effects. This study aimed to examine the antihyperglycemic effect of ethanol extract and ethyl acetate fraction of breadfruit leaves on alloxan-induced diabetic male white rats (Rattus norvegicus). Subjects and Method: This was a randomized controlled trial. Sample was 35 male white Wistar rats (Rattus norvegicus sp.) divi

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Satyanarayana, S., K. Eswar Kumar та J. Raja Sekhar. "Effect of α-lipoic acid on gliclazide-induced hypoglycemia/antihyperglycemia in normal/alloxan-induced diabetic rats". Therapy 3, № 5 (2006): 613–17. http://dx.doi.org/10.2217/14750708.3.5.613.

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20

Ankolekar, Chandrakant, Marcia Pinto, Duane Greene, and Kalidas Shetty. "In vitro bioassay based screening of antihyperglycemia and antihypertensive activities of Lactobacillus acidophilus fermented pear juice." Innovative Food Science & Emerging Technologies 13 (January 2012): 221–30. http://dx.doi.org/10.1016/j.ifset.2011.10.008.

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21

Fan, Zhuo, Ting Wen, Yaoxu Chen, et al. "Isosteviol Sensitizes sarcKATPChannels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/6362812.

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KATPchannel is an important mediator or factor in physiological and pathological metabolic pathway. Activation ofKATPchannel has been identified to be a critical step in the cardioprotective mechanism against IR injury. On the other hand, desensitization of the channel to its opener or the metabolic ligand ATP in pathological conditions, like cardiac hypertrophy, would decrease the adaption of myocardium to metabolic stress and is a disadvantage for drug therapy. Isosteviol, obtained by acid hydrolysis of stevioside, has been demonstrated to play a cardioprotective role against diseases of car

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22

Ramadhan, Galang Pergiawan, Iis Wahyuningsih, and Wahyu Widyaningsih. "Development of transdermal patch preparations binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and antihyperglycemia test in rats." Pharmaciana 13, no. 2 (2023): 224. http://dx.doi.org/10.12928/pharmaciana.v13i1.24602.

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23

Kan, Wei-Chih, Shu-Chun Kuo, Tsair-Wei Chien, et al. "Therapeutic Duplication in Taiwan Hospitals for Patients With High Blood Pressure, Sugar, and Lipids: Evaluation With a Mobile Health Mapping Tool." JMIR Medical Informatics 8, no. 7 (2020): e11627. http://dx.doi.org/10.2196/11627.

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Background Cardiovascular disease causes approximately half of all deaths in patients with type 2 diabetes. Duplicative prescriptions of medication in patients with high blood pressure (hypertension), high blood sugar (hyperglycemia), and high blood lipids (hyperlipidemia) have attracted substantial attention regarding the abuse of health care resources and to implement preventive measures for such abuse. Duplicative prescriptions may occur by patients receiving redundant medications for the same condition from two or more sources such as doctors, hospitals, and multiple providers, or as a res

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24

Pasaribu, Ronald, Salomo Hutahaean, and Syafruddin Ilyas. "Test Antihyperglycemia Ethanol Leaf Extract Kembang Bulan ( Tithonia diversifolia) in Mice ( Mus musculus ) The Induced Diabetes With alloxan." JURNAL BIOSAINS 1, no. 2 (2016): 36. http://dx.doi.org/10.24114/jbio.v1i2.2785.

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A research was conducted to invenstigate antihyperglycemic activity ethanol extract of leaf kembang bulan (Tithonia diversifolia) in mice with alloxan induced diabetes. The experiment used completely randomized design, 6 treatment groups with 5 replicates each. KP mice, P1, P2, P3 and P4 fasted for 16 hours and then injected intraperitoneally alloxan 5.04 mg. On day 4 post induction, KP, P1, P2, P3 and P4 positive diabetes. P1, P2 and P3 were treated 14; 42 and 70 mg/Kg of ethanol extract of kembang bulan while P4 were 0.9 mg/Kg glibenclamide for 12 days. The results showed that all treatment

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Ma, Hang, Yinran Hu, Zongyao Zou, Min Feng, Xiaoli Ye, and Xuegang Li. "Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice." Drug Development Research 77, no. 4 (2016): 163–70. http://dx.doi.org/10.1002/ddr.21302.

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26

Pinto, Diana C. G. A., Mark A. M. Simões, and Artur M. S. Silva. "Genista tridentata L.: A Rich Source of Flavonoids with Anti-Inflammatory Activity." Medicines 7, no. 6 (2020): 31. http://dx.doi.org/10.3390/medicines7060031.

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Background: Genista tridentata L. is an endemic species from the Iberian Peninsula used in Portuguese traditional medicine to treat inflammation-related diseases; this and other health-promoting effects are usually associated with the flavonoids produced by this species. In fact, anti-inflammatory properties were established for several of these flavonoid derivatives. Methods: A careful survey of the reported data, using mainly the Scopus database and Genista tridentata and Pterospartum tridentatum as keywords, was done. We have examined the papers involving the plant and those about the most

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Imam, Mustapha Umar, Nur Hanisah Azmi, Muhammad Iqbal Bhanger, Norsharina Ismail, and Maznah Ismail. "Antidiabetic Properties of Germinated Brown Rice: A Systematic Review." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/816501.

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Diet is an important variable in the course of type 2 diabetes, which has generated interest in dietary options like germinated brown rice (GBR) for effective management of the disease among rice-consuming populations.In vitrodata and animal experiments show that GBR has potentials as a functional diet for managing this disease, and short-term clinical studies indicate encouraging results. Mechanisms for antidiabetic effects of GBR due to bioactive compounds likeγ-aminobutyric acid (GABA),γ-oryzanol, dietary fibre, phenolics, vitamins, acylated sterylβ-glucoside, and minerals include antihyper

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Darmanto, Yanski, Razoki ., and Elfia Neswita. "Antihyperglycemic Effects of Active Fraction of Ethanol Extract from Castanopsis costata Leaves and Channa striata Extract on Rats." Galore International Journal of Health Sciences and Research 9, no. 2 (2024): 104–11. http://dx.doi.org/10.52403/gijhsr.20240214.

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Anti-hyperglycemic experiments were conducted on male Wistar rats divided into six groups: Group 1 (negative control), Group 2 (active fraction of Castanopsis costata ethanol extract at 200 mg/kg body weight), Group 3 (Channa striata extract at 250 mg/kg body weight), Group 4 (active fraction of Castanopsis costata ethanol extract at 50 mg/kg body weight + Channa striata extract at 250 mg/kg body weight), Group 5 (active fraction of Castanopsis costata ethanol extract at 100 mg/kg body weight + Channa striata extract at 250 mg/kg body weight), and Group 6 (active fraction of Castanopsis costat

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Azantsa, Kingue Gabin Boris, Nouteza Imelda Djuikoo, Tchetmi Wilfried Kuikoua, Guy Takuissu, Laure Ngondi Judith, and Oben Julius. "Phytochemical Screening and Anti-diabetic Evaluation of Citrus sinensis Stem Bark Extracts." International Journal of Biochemistry Research & Review 17, no. 2 (2017): 1–13. https://doi.org/10.9734/IJBCRR/2017/34051.

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<strong>Aim: </strong>Diabetes Mellitus remains amongst the highest cause of mortality in the world. This study was carried out to determine the phytochemical composition of stem bark extracts of <em>Citrus sinensis </em>and study their anti-hyperglycaemic activities as well as their modulatory effects on starch and sucrose digestion on normal Wistar rats. <strong>Methodology:</strong> Stem bark Aqueous (AqE), Ethanolic (EtE), Hydroethanolic (HEE) extracts of <em>C. sinensis </em>were prepared. The content of polyphenols, flavonoids, alkaloids was determined. Anti-hyperglycaemic activity was e

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Ontawong, Atcharaporn, Naruwan Saowakon, Pornpun Vivithanaporn, et al. "Antioxidant and Renoprotective Effects ofSpirogyra neglecta(Hassall) Kützing Extract in Experimental Type 2 Diabetic Rats." BioMed Research International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/820786.

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Spirogyra neglectaextract (SNE) has shown antihyperglycemia and antihyperlipidemia in type 2 diabetic mellitus (T2DM) rats. This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin. T2DM rats were fed daily with SNE (0.25, 0.5, and 1 g/kg BW) for 12 weeks. Renal morphology, malondialdehyde levels, qPCR, and western blotting were analyzed. Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate andpara-aminohippurate, mediated through organic anion transpo

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Xu, Xiaoxiang, Yingjia Wei, Mian Khaqan Shah, et al. "Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia." Oxidative Medicine and Cellular Longevity 2020 (April 3, 2020): 1–11. http://dx.doi.org/10.1155/2020/3183104.

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Active peptides have good effectiveness in controlling or preventing many diseases. Compound active peptides (CAP) obtained from animal, plant, and sea food proteins were used in this study to explore their effects on antioxidation, anti-inflammation, and antihyperglycemia in vitro and in vivo. The results demonstrated that 10 μg/mL CAP could increase cell viability (P<0.05) and decrease reactive oxygen species (ROS) levels and cell apoptosis (P<0.05) when WRL68 cells were induced by H2O2 for 6 h. Moreover, incubation with 20 μg/mL CAP for 6 h significantly increased cell viability and B

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Firdaus, M. Rizky, Ifora Ifora, and Sri Oktavia. "Phytochemical and Pharmacological Studies of Rhaphidophora pinnata (L.f.) Schott.: A Review." EAS Journal of Pharmacy and Pharmacology 5, no. 04 (2023): 93–97. http://dx.doi.org/10.36349/easjpp.2023.v05i04.002.

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Background/ Objective: plants that function primarily to maintain individual health and improve the quality of life throughout the year. a traditional plant as traditional medicine is dragon tail leaves (R. pinnata (L.f.) Schott.). Therefore, this review aims to share reports and provide a comprehensive explanation of the phytochemical and pharmacological activities of (R. pinnata (L.f.) Schott.). Methods: evaluation shared facts in the literature on phytochemical activity and pharmacological activity (R. pinnata (L.f.) Schott.) through 2012-2022. Three bibliographical databases were used to o

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Salsabilla, Salma Febriani Nur, and Cikra Ikhda Nur Hamidah Safitri. "Combination of Secang (Caesalpinia sappan L.) and Glibenclamide in Mice (Mus Muscullus) Hyperglycemia." MEDFARM: Jurnal Farmasi dan Kesehatan 14, no. 1 (2025): 58–64. https://doi.org/10.48191/medfarm.v14i1.562.

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Diabetes is a disease whose sufferers continue to increase in Indonesia. The International Diabetes Federation (IDF) in 2019, estimated around 463 million people with the disease. This figure is likely to continue to increase, up to 578 million in 2030 and 700 million in 2045. The use of herbal medicines is now growing, one of which comes from the secang woods (Caesalpinia sappan L.). The plant is rich in active bioactive components such as flavonoids and tannins. The flavonoids contained in secang have the ability to inhibit the enzyme α-glucosidase which plays a role in lowering the reabsorp

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Alexandra, Francisca Diana, Satriyandi M, Agnes Frethernety, and Triawanti Triawanti. "Influence of Extract Swiftlet Nest (Collocalia Fuciphago) as Antihyperglycemia to Circulating Endothelial Cells in Rat (Rattus novergicus) Induced by Streptozotocin." Berkala Kedokteran 14, no. 1 (2018): 1. http://dx.doi.org/10.20527/jbk.v14i1.4528.

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Abstract: Hyperglycemia could increase the oxidative stress by catalyzes the formation of free radical as anion superoxide(O2-). Oxidative stress will effect in endothelial damaged. This study aimed to evaluated the influence of extract swiftlet nest (Collocalia fuciphago) to glucose level and CEC in rat (Rattus novergicus). Rats were classified into 4 groups, there were control group (K) and 3 treatments group (dose 1; 10 and 100 mg / kgBW) The seventh day after induced by Streptozotozin (i.p), the rats had increased glucose ± 102 – 108 mg/dL, then treated with the extract of Swiftlet nest fo

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Eskin, Maxim, Scot H. Simpson, and Dean Trevor Eurich. "Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes." Canadian Journal of Diabetes 43, no. 5 (2019): 322–28. http://dx.doi.org/10.1016/j.jcjd.2018.12.001.

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Fujita, Alice, Dipayan Sarkar, Shibiao Wu, Edward Kennelly, Kalidas Shetty, and Maria Inés Genovese. "Evaluation of phenolic-linked bioactives of camu-camu ( Myrciaria dubia Mc. Vaugh) for antihyperglycemia, antihypertension, antimicrobial properties and cellular rejuvenation." Food Research International 77 (November 2015): 194–203. http://dx.doi.org/10.1016/j.foodres.2015.07.009.

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37

BARBOSA, ANA CRISTINA LOPES, MARCIA DA SILVA PINTO, DIPAYAN SARKAR, CHANDRAKANT ANKOLEKAR, DUANE GREENE, and KALIDAS SHETTY. "INFLUENCE OF VARIETAL AND pH VARIATION ON ANTIHYPERGLYCEMIA AND ANTIHYPERTENSION PROPERTIES OF LONG-TERM STORED APPLES USING IN VITRO ASSAY MODELS." Journal of Food Biochemistry 36, no. 4 (2011): 479–93. http://dx.doi.org/10.1111/j.1745-4514.2011.00554.x.

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Ab Rahman, Nur Syukriah, Fadzilah Adibah Abd Majid, Effendy Abd Wahid, Ain Nabihah Zainuddin, and Hassan Fahmi Ismail. "SUB-ACUTE TOXICITY STUDY OF DIABECINE RECONSTITUTE IN SPRAGUE-DAWLEY RATS: A PRELIMINARY STUDY IN THE EVALUATION AS AN ANTIHYPERGLYCEMIA AGENT." Jurnal Teknologi 85, no. 5 (2023): 125–31. http://dx.doi.org/10.11113/jurnalteknologi.v85.19023.

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Diabecine reconstitute is a combination of well-known herbs such as Cinnamomum zeylanicum, Eugenia polyantha, Curcuma xanthorizza, Orthosiphon stamineus and Andrographis paniculata which are believed to give promising finding especially in the treatment of diabetes mellitus. However, no scientific studies have been performed to investigate its toxicological effect. Therefore, this study aimed to evaluate its safety profile using sub-acute toxicity (14 days repeated doses) in rat model. The sub-acute toxicity study was evaluated by daily administration of different doses (250, 600 and 2000 mg/k

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Wu, Ching-Feng, Po-Hsun Hou, Frank Chiahung Mao, et al. "Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice." Animals 10, no. 8 (2020): 1423. http://dx.doi.org/10.3390/ani10081423.

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Metabolic syndrome is known to engender type 2 diabetes as well as some cardiac, cerebrovascular, and kidney diseases. Mirtazapine—an atypical second-generation antipsychotic drug with less severe side effects than atypical first-generation antipsychotics—may have positive effects on blood glucose levels and obesity. In our executed study, we treated male high-fat diet (HFD)-fed C57BL/6J mice with mirtazapine (10 mg/kg/day mirtazapine) for 4 weeks to understand its antiobesity effects. We noted these mice to exhibit lower insulin levels, daily food efficiency, body weight, serum triglyceride l

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Guo, Jing, Hui Juan Zheng, Wenting Zhang, et al. "Accelerated Kidney Aging in Diabetes Mellitus." Oxidative Medicine and Cellular Longevity 2020 (July 28, 2020): 1–24. http://dx.doi.org/10.1155/2020/1234059.

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With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent auto

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Edi Kamal, Sainal, Alfreds Roosevelt, Gerfan Patandung, and Achmad Amiruddin. "The Potential of Hyperglycemia Combination of Watermelon (Citrullus lanatus) Rind Extract and Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract." Jurnal Farmasi Sandi Karsa 9, no. 2 (2023): 74–82. http://dx.doi.org/10.36060/jfs.v9i2.129.

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This study aims to determine the potential hyperglycemia of the combination of Watermelon Skin Extract (Citrullus lanatus) and Red Dragon Fruit Skin Extract (Hylocereus polyrhizus). The research method used is the alloxane induction method. Rats were divided into 5 groups, namely positive control given metformin 45 mg / Kg BB, negative control given Na. CMC 1% w/v, and variations of test groups given combination extracts with concentration variations of 6% and 13.4%; 9% and 16.4%; and 12% and 19.4% then each group was induced alloxane at a dose of 24 mg / 200g BB. The results of the study on t

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Rozi, Zico Fakhrur, Aceng Ruyani, and Badeni. "Development Of A Steam-Based Homeostatic Module To Improve Students' Cognitive Abilities." Jurnal Penelitian Pendidikan IPA 10, no. 6 (2024): 3099–107. http://dx.doi.org/10.29303/jppipa.v10i6.7253.

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This research aims to develop a STEAM-based homeostatic module to improve students' cognitive abilities. The subjects of this research were students of the Biology Education Study Program at PGRI Silampari University. In the learning process, students are given an assignment in the form of a project to test honje fruit extract (Etlingera hemisphaerica) as antihyperglycemia, antihypercholesterolemia and antihyperuricemia. Module development uses a 4D development model, with define, design, develop and disseminate stages. The instruments in the research are validation questionnaires for material

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Susanto, Kuncoro Adi, Maura Linda Sitanggang, Delina Hasan, and Ida Chorida. "Analysis Of Prescription of National Formularium Medicines Based on The Adjustment of Restriction in Public Hospitals of Sawah Besar 2018." JURNAL ILMU KEFARMASIAN INDONESIA 19, no. 1 (2021): 68. http://dx.doi.org/10.35814/jifi.v19i1.1056.

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Health services provided to the public in the implementation of the National Health Insurance (NHI) includepromotional, preventive, curative and rehabilitative. In supporting the implementation of NHI, it is necessaryto make eff orts to ensure the availability, aff ordability and accessibility of medicines through the application of the National Formulary (Fornas) as a reference in health services in all health facilities. The purpose of this study was to determine the percentage of prescription drugs in accordance with the National Formulary at Sawah Besar Hospital in 2018. The research desig

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Riany, Hesti. "Effects of Coffee Consumption In Improving Hyperglicemia In Diabetes-Induced Mice." International Journal of Ecophysiology 1, no. 1 (2019): 72–80. http://dx.doi.org/10.32734/ijoep.v1i1.850.

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Diabetes mellitus (DM) is a chronic metabolic disease. It was caused by lack of insulin or cells cannot use insulin so that blood glucose becomes high (hyperglycemia). And it will cause other systemic diseases of the disease (metabolic syndrome) that can increase the factor of death. Coffee is one of the consumed plants that contain antioxidants and chlorogenic acid that have a role as antihyperglycemia. In other hand Jambi as one of the coffee producing regions (arabica, robust and liberica) in Sumatra and it has a potency as a coffee producer. In addition, people's habits in consuming coffee

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Dewi, Aptika Oktaviana Trisna, Ahmad Fatih Maulana Wakhid, Rafli Yusup, and Annora Rizky Amalia. "Effect of Different Drying Methods on the Characteristics of Curcuma zedoaria rhizome." International Journal of Scientific Research and Management (IJSRM) 12, no. 07 (2024): 1094–99. http://dx.doi.org/10.18535/ijsrm/v12i07.mp02.

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Curcuma zedoaria is one of the plants that has the potential to be developed as raw material for making traditional medicine. The results of the study showed that white ginger has diverse pharmacological activities such as antihyperglycemia, antihyperlipids, antihypercholesterol, antiviral, anticancer / antitumor, immunomodulators, analgetics, anti-inflammatory, antipyretic and antioxidants. In the production process of traditional medicines, the quality of simplicia used as raw materials must meet quality standards in order to provide a good therapeutic effect. The quality of white intersecti

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Ajiboye, Basiru Olaitan, Oluwafemi Adeleke Ojo, Babatunji Emmanuel Oyinloye, et al. "Investigation of the In Vitro Antioxidant Potential Of Polyphenolic-Rich Extract of Artocarpus heterophyllus Lam Stem Bark and Its Antidiabetic Activity In Streptozotocin-Induced Diabetic Rats." Journal of Evidence-Based Integrative Medicine 25 (January 1, 2020): 2515690X2091612. http://dx.doi.org/10.1177/2515690x20916123.

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Artocarpus heterophyllus Lam (Moraceae) stem bark has been used locally in managing diabetes mellitus with sparse scientific information. This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of A heterophyllus stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Fifty male Wistar rats were used with the induction of diabetes by a single intraperitoneal injection of streptozotocin (45 mg/kg body weight) and were orally administered 400 mg/kg free and bound phenols of A heterophyllus stem bark. The animals were sacrificed on t

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Adegoke, A. O., A. O. Durodola, S. A. Adesina, et al. "Unintentional Weight Loss from Metformin Despite Good Glycaemic Control in a Newly Diagnosed Diabetic Patient." International Journal of Medical and Pharmaceutical Case Reports 16, no. 2 (2023): 14–18. http://dx.doi.org/10.9734/ijmpcr/2023/v16i2329.

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Aim: To present a case of unintentional weight loss from Metformin despite good glycaemic control in a newly diagnosed diabetic patient. Case Presentation: A 60-year-old previously diagnosed hypertensive and recently diagnosed type 2 diabetic patient with good glycaemic and blood pressure control presented with progressive weight loss in the last one year while on medication. Her normal state weight was 84.6kg, height 1.70m2 (BMI 29.27kg/m2) which dropped to 70kg (BMI 20.26Kg/mg2) at the point she was diagnosed with type 2 diabetes mellitus (T2DM). She was counselled about dietary and li

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Wahjuni, S., N. M. Puspawati, and I. B. P. Manuaba. "The nano mixture of ethanol extract ketumbar (Coriandrum sativum L.) seed and putri malu (Mimosa pudica L.) leaves potentially reduced blood glucose levels in hyperglycemia wistar rat." IOP Conference Series: Earth and Environmental Science 1255, no. 1 (2023): 012067. http://dx.doi.org/10.1088/1755-1315/1255/1/012067.

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Abstract The formation of nano extracts can increase the bioactivity of a compound in the body. The purpose of this study was to determine the ability of a nano mixture of Coriandrum sativum L seed and ethanol extract of Mimosa pudica L leaves to reduce glucose levels in hyperglycemic rats, compared to an ethanolic extract mixture of Coriandrum sativum L seeds and Mimosa pudica L leaves. The size and zeta potential characterization of the ethanolic extract mixture of Coriandrum sativum L seed and Mimosa pudica L leaves was carried out using a Particle Size Analyzer (PSA). The results of charac

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Cheng, Judy W. M., Vincent J. Colucci, James S. Kalus, and Sarah A. Spinler. "Managing Diabetes and Preventing Heart Disease: Have We Found a Safe and Effective Agent?" Annals of Pharmacotherapy 53, no. 5 (2018): 510–22. http://dx.doi.org/10.1177/1060028018816466.

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Objective: While improving glycemic control with antihyperglycemics has been demonstrated to reduce microvascular complications, the benefits of reduction in cardiovascular diseases (CVDs) have not been demonstrated with older agents. This article reviews current evidence of the CV outcomes of newer antihyperglycemics approved since 2008. Data Sources: Peer-reviewed articles were identified from MEDLINE (1966 to October 31, 2018) using search terms exenatide, liraglutide, lixisenatide, dulaglutide, semaglutide, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin, dapagliflozin, em

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Hanjaya, Hanjaya. "EFFECTIVENESS OF BASIL LEAF (OCIUM BASILICUM L.) NANOHERBAL AS ANTIHYPERGLYCEMIAIN STREPTOZOTOCIN – INDUCED DIABETIC RAT." Jambura Journal of Health Sciences and Research 4, no. 3 (2022): 849–58. http://dx.doi.org/10.35971/jjhsr.v4i3.13460.

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Diabetes merupakan penyakit kronis yang terjadi di saat insulin yang diproduksi oleh tubuh tidak bisa digunakan secara efektif maupun organ pankreas mengalami masalah dimana insulin tidak dapat diproduksi sebagaimana mestinya. Diabetes Mellitus dibagi menjadi dua jenis yaitu IDDM (DM tipe I) dan NIDDM (DM tipe 2. Kebaruan penelitian ini menguji efektivitas nonherbal kemangi sebagai antihiperglikemia pada tikus diabetes yang terindukasi streptozotocin. Penelitian ini bertujuan untuk menganalisis dan meninjau hewan dan penelitian pada tikus putih yang diinduksi STZ. Pencarian elektronik dilakuka

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