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Journal articles on the topic 'Antihyperlipidemic activity'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Rong, A., Narisu Bao, Zhaorigetu Sun, Gereltu Borjihan, Yanjiang Qiao, and Zhuang Jin. "Synthesis and Antihyperlipidemic Activity of Piperic Acid Derivatives." Natural Product Communications 10, no. 2 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000218.

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A series of piperic acid derivatives were designed and synthesized from piperine/ piperlonguminine, and their antihyperlipidemic activities evaluated in diet-induced hyperlipidemic rats with respect to simvastatin. Two promising analogues 3 and 10 were discovered and their antihyperlipidemic activities were comparable to or better than those of simvastatin.

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2

Shedage, Ashish Tukaram, and Rukhsana Mahiboob Pinjari. "A Review on Antihyperlipidemic Activity of Medicinal Plants." International Journal of Forest, Animal And Fisheries Research 7, no. 5 (2023): 33–38. http://dx.doi.org/10.22161/ijfaf.7.5.5.

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The researchers wanted to see whether any plants had any antihyperlipidemic action, therefore they conducted this investigation. It's the single greatest contributor to potential cardiovascular problems. As a result, there are several negative effects associated with allopathic antihyperlipidemic medications. Many people rely on medicinal plants as a means of treatment, and this has a substantial effect on the world economy. In many parts of the world's healthcare infrastructure, herbal treatments made from herbs, herbs, and herbs play a crucial role. Herbal medication is becoming more popular

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3

Jagadeeshwar., K* and P. Sravan Kumar. "EVALAUTION OF ANTIHYPERLIPIDEMIC ACTIVITY OF TEPHROSIA PURPUREA PLANT EXTRACTS IN MICE." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1377–83. https://doi.org/10.5281/zenodo.804914.

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In this work the cold extraction process was done with the help of methanol. About 200gms of powdered material was taken in a clean, flat bottomed glass container and soaked in 750 ml of methanol. The container with its contents were sealed and kept for period of 7 days accompanied by continuous shaking with the shaker. The whole mixture then went under a coarse filtration by a piece of a clean, white cotton wool.Investigation revealed the presence of Alkaloid, Tannin, Saponin, Phenol in Methanolic Extract of Tephrosia purpurea while only Phenol were present in Phenolic Extract of Tephrosia pu

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4

Lin, Yung-Pin, Li-Yun Lin, Hsiang-Yu Yeh, Cheng-Hung Chuang, Sheng-Wen Tseng, and Yue-Horng Yen. "Antihyperlipidemic activity of Allium chinense bulbs." Journal of Food and Drug Analysis 24, no. 3 (2016): 516–26. http://dx.doi.org/10.1016/j.jfda.2016.01.010.

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5

Tyagi, Priya, Satish Kumar Sharma, and Pawan Kumar. "Evaluation of antihyperlipidemic activity of ethanolic root extract of Glycyrrhiza glabra Linn." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 120–24. http://dx.doi.org/10.22270/jddt.v8i6-s.2098.

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Glycyrrhiza glabra Linn. is an Indian medicinal plant demonstrated to exert multiple health cures. This plant grows naturally in tropical, subtropical and temperate regions. It is traditionally used as anti-acne, anti-arthritic, anti-convulsant, anti-diabetic, anti-microbial, anti inflammatory, wound healing, anti-oxidant, anti-platelet, anti-stress and nootropic, anti-viral, diuretic and gastroprotective. The antihyperlipidemic effect of ethanolic root extracts of Glycyrrhizaglabrawas studied in wistar rats using High Fat Diet (FD) induced hyperlipidemic model, at the doses of 400 mg/kg body

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6

Cn, Sarvesh, and Jennifer Fernandes. "EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF LEAVES OF ACHYRANTHES ASPERA Linn USING HYPERLIPIDEMIC RATS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 211. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16576.

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Objective: Plants have been one of the important sources of medicines since the beginning of human civilization. Achyranthes aspera Linn. belongingto family Amaranthaceae, commonly found in India. The plant is used as antiarthritic, purgative, diuretic, antimalarial, etc.Methods: The antihyperlipidemic activity of alcoholic and aqueous extracts of leaves of A. aspera was evaluated using triton-induced hyperlipidemiamodel in albino Wistar rats. The acute toxicity study confirmed that both the extracts were found to be safe at 5000 mg/kg b.w. in female albinoWistar rats. In this model, eight gro

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7

Lukas, Lisye Marrilyn. "The potential of plant extracts containing flavonoids as anti-hyperlipidemia: A literature review." Indonesia Journal of Biomedical Science 17, no. 2 (2023): 224–26. http://dx.doi.org/10.15562/ijbs.v17i2.481.

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One of the risk factors that cause cardiovascular disease is hyperlipidemia. Hyperlipidemia is a condition of increased plasma fat levels consisting of increased cholesterol, triglycerides and LDL levels and decreased HDL levels. The existence of side effects on the body from antihyperlipidemic drug treatment makes herbal medicine one of the alternatives chosen as a treatment for hyperlipidemic patients. Antihyperlipidemic activity testing was carried out on various herbal plants that contain antioxidants. There are 6 types of plant extracts with activity test results that have potential as an

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8

Agrawal, Ankur, and Subodh K. Dubey. "Evaluation of Polyherbal Formulation for Antihyperlipidemic Activity." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 101–5. http://dx.doi.org/10.25258/ijpqa.15.1.15.

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Hyperlipidemia, characterized by elevated plasma concentrations of lipids and lipoproteins, emerged as a decisive menace for cardiovascular disorders. Imminent side effects linked to synthetic drugs; there is a growing interest in exploring herbal remedies for managing hyperlipidemia. This study delves into examining the antihyperlipidemic effects of a polyherbal formulation composed of extracts from Ailanthus excelsa Roxb (leaves and stems), Cymbopogon citratus (leaves), and Allium sativum (bulbs). The PHF was orally administered at 200 and 400 mg/kg doses. Results revealed a noteworthy reduc

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9

Goutam, Nidhi, and Reni Kapoor. "Evaluation of Antidiabetic and Antihyperlipidemic Effect of Ethanolic Leaves Extract of Centratherum anthelminticum (L) Kuntze against STZ Induced Diabetic Rats." Journal of Drug Delivery and Therapeutics 10, no. 2-s (2020): 140–48. http://dx.doi.org/10.22270/jddt.v10i2-s.4014.

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Objective: To evaluate the Antidiabetic & Antihyperlipidemic effect of Centratherum Anthelminticum (L) Kuntze extract against STZ induced diabetic rats. Methods: The present study examined the influence of Centratherum Anthelminticum extract (CASE), on blood glucose level and antioxidant enzymes level in STZ induced diabetic rats. The possible effects of chronic administration of the extract on the fasting serum glucose, insulin, and total cholesterol and triglycerides levels in STZ-induced diabetic rats were also evaluated. Results: The extracts showed a marked Antidiabetic &a

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10

Sneha, J. Anarthe* M. Swetha P. Spoorthisudha and M. Ganga Raju. "ANTIOXIDANT AND ANTIHYPERLIPIDAEMIC ACTIVITY FOR METHANOLIC EXTRACT OF NYCTANTHES ARBORTRISTIS LEAVES." iajps,csk publications 03, no. 12 (2016): 1470–81. https://doi.org/10.5281/zenodo.221657.

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Objective: The present study was to evaluate the antihyperlipidemic activity for methanolic extract of Nyctanthes arbor-tristis (Linn.) leaves. Methodology: Methanolic extract of Nyctathes arbor-tristis (MENA) was evaluated for in vitro antioxidant assay by reducing power assay and hydrogen peroxide assay and in vivo models of antihyperlipidemic study was carried out by 3 methods those are cholesterol diet, triton 100 X and fructose. The serum was collected and analyzed for lipid profile total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipopr

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11

Soujanya H, Purushothaman M, Jagadeeshwari S, and Shiva Kumar K. "Evaluation of antihyperlipidemic activity of polyherbal capsules." International Research Journal of Pharmaceutical and Applied Sciences 8, no. 1 (2018): 1–4. http://dx.doi.org/10.26452/irjpas.v8i1.1306.

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Hypercholesterolemia is one of the dreadful conditions that coexist in almost all the heart and endocrine-related dysfunctions. Simply elevated cholesterol levels in the blood is termed as hypercholesterolemia. Hyperlipidemia is also a synonym term and used to define elevated lipid levels. It affects almost all human beings in the world currently because of the changes in the food and living habits of the people. Most works proved those chemical constituents are antioxidants that demonstrate that the assertion that the oxidation is the main problem in causing the hyperlipidemia. So, in this re

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12

D, Mungunnaran, Gereltu B, and Bayarmaa B. "Antihyperlipidemic activity of newly synthesized piperlonguminine acid." Mongolian Journal of Agricultural Sciences 25, no. 03 (2018): 97–105. http://dx.doi.org/10.5564/mjas.v25i03.1177.

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Abnormalities in lipid metabolism cause many diseases, including atherosclerosis. By this study, we proposed to synthesize a novel derivative from piperine and identify its hypolipidemic effect. For this, piperlonguminine acid (GBN-COOH) was synthesized as a piperine derivative from Piper longum Linn. successfully. The molecular structure of the GBN-COOH was confirmed by 13C and 1H NMR, ES-MS methods and it was administered orally to high-fat diet fed rats. Compared with model rats, oral administration of GB-COOH at dose of 10 mg/kg to hyperlipidemic rats could significantly decrease the level

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K., Anupama Priyadarshini1 Dr. G. Sudhakara Rao2 G. Sandeep Kumar3 D. Raju4 B.Pragna Malavika5. "ANTIHYPERLIPIDEMIC ACTIVITY OF RUELLIA TUBEROSA ROOT EXTRACT." International Journal of Medical Research and Pharmaceutical Sciences 7, no. 3 (2020): 12–32. https://doi.org/10.5281/zenodo.3707729.

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The <em>Ruellia tuberosa</em> L. have both Chronic hyperlipidemia was induced by feeding female rats with High Fat Diet for 30 days. Acute hyperlipidemia was induced by administration of Triton X-100 (100mg/kg, i.p., at once) in female rats. Administration of Ruellia tuberosa Ethanolic extract (RTEE) (250/500/1000mg/kg) for 30 days in High Fat Diet (HFD) model and RTEE (250/500/1000mg/kg) for 7 days in triton models respectively, successfully prevented the elevation of serum triglycerides(TG), total cholesterol(TC),Low density lipoproteins(LDL), Very Low density lipoproteins (VLDL), Serum glut

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14

Sneha, J. Anarthe* M. Swetha P. Spoorthisudha and M. Ganga Raju. "ASSESSMENT OF ANTIHYPERLIPIDEMIC ACTIVITY FOR METHANOLIC EXTRACT OF NYCTANTHES ARBOR-TRISTIS (LINN.) LEAVES." iajps,csk publications 03, no. 12 (2016): 1470–81. https://doi.org/10.5281/zenodo.221366.

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Objective: The present study was to evaluate the antihyperlipidemic activity for methanolic extract of Nyctanthes arbor-tristis (Linn.) leaves. Methodology: Methanolic extract of Nyctathes arbor-tristis (MENA) was evaluated for in vitro antioxidant assay by reducing power assay and hydrogen peroxide assay and in vivo models of antihyperlipidemic study was carried out by 3 methods those are cholesterol diet, triton 100 X and fructose. The serum was collected and analyzed for lipid profile total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipopr

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15

PANDEY, PRIYA. "ANTIDIABETIC ACTIVITY OF CAESALPINIA BONDUCELLA LEAVESs OF HYDRO ALCOHOLIC EXTRACTS IN ALBINO RATS." YMER Digital 21, no. 07 (2022): 840–46. http://dx.doi.org/10.37896/ymer21.07/67.

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The anti-diabetic effect of Caesalpinia bonducella leaf extracts was tested in streptozotocininduced hyperglycemia. Significant antihyperglycemic effect was generated by oral treatment of the extracts (400 mg/kg). The same study examined the effects of the extracts on diabetesinduced hyperlipidemia, finding that they dramatically reduced both the raised cholesterol and LDL levels. The extracts' antihyperglycemic effects may be brought about by their ability to prevent glucose absorption. The medicine may have both antidiabetic and antihyperlipidemic effects. Keywords: - Caesalpinia bonducella,

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16

Rajum, Ganga, Hema Sundar Reddy T, and Hema Sundar Reddy T. "ARISTOLOCHIA BRACTEOLATA – ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY IN DEXAMETHASONE-INDUCED DIABETIC RAT MODEL." Asian Journal of Pharmaceutical and Clinical Research 10, no. 8 (2017): 75. http://dx.doi.org/10.22159/ajpcr.2017.v10i8.18328.

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Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose leve

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17

Solanki, Yogendrasinh B., and Sunita M. Jain. "Antihyperlipidemic activity ofClitoria ternatea and Vigna mungoin rats." Pharmaceutical Biology 48, no. 8 (2010): 915–23. http://dx.doi.org/10.3109/13880200903406147.

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18

Hu, Ming, Xue-Qiong Yang, Chuen-Ping Wan, et al. "Potential antihyperlipidemic polyketones from endophytic Diaporthe sp. JC-J7 in Dendrobium nobile." RSC Advances 8, no. 73 (2018): 41810–17. http://dx.doi.org/10.1039/c8ra08822e.

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19

Bouhrim, Mohamed, Nour Elhouda Daoudi, Hayat Ouassou, et al. "Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil." Scientific World Journal 2020 (September 28, 2020): 1–8. http://dx.doi.org/10.1155/2020/5717052.

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Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evalu

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20

Kannur, Dayanand, and Kishanchandra Khandelwal. "Phytochemical Investigation and Evaluation of Antihyperlipidemic Activity of Ficus Carica Linn Fruit Extracts." Global Journal For Research Analysis 3, no. 6 (2012): 184–87. http://dx.doi.org/10.15373/22778160/june2014/63.

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21

Fattepur, Santosh, Kiran Chanabasappa Nilugal, Ranya Rajendran, Fadli Asmani, and Eddy Yusuf. "ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF BOESENBERGIA PANDURATA (FINGER ROOT) IN EXPERIMENTAL INDUCED HYPERCHOLESTROLEMIC SPRAGUE DAWLEY RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 15 (2018): 8. http://dx.doi.org/10.22159/ajpcr.2018.v11s3.29962.

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Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidemic activity of methanolic extracts of B. pandurata rhizomes (BPR extracts) in hypercholesterolemia-induced Sprague-Dawley rats.Methods: BPR extracts were prepared using the maceration method with 1500 ml of 80% methanol at room temperature for about

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22

Munwar, Shaik, K. Ilango, and M. K. Kathiravan. "Synthesis, Molecular Docking Studies and in vitro and in vivo Hypolipidemic Activity of Thiazolidinedione Derivatives." Asian Journal of Chemistry 36, no. 2 (2024): 434–48. http://dx.doi.org/10.14233/ajchem.2024.31107.

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This work aimed to design, synthesize novel thiazolidinedione derivatives, which were tested for their antihyperlipidemic effects. Antihyperlipidemic activity was carried through in silico docking study for the 50 thiazolidinedione derivatives (SMI-IV-1 to 50 derivatives) in comparison with standard pioglitazone against the crystal structure of protein PPARgamma (PDB ID: 6QJ5) proteins. Based on the binding energy further, best three derivatives were selected and characterized with IR, NMR and MASS studies. Then, in vitro evaluation of each derivative's antihyperlipidemic activity was carried

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23

Shofi, Muh. "Activity of Phenolic Compounds in Figs (Ficus carica L.) as Antihyperlipidemic through in Silico Study." Journal Of Biology Education 5, no. 1 (2022): 79. http://dx.doi.org/10.21043/jobe.v5i1.13995.

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<p>Figs (Ficus carica L.) belongs to family Moraceae which contains a lot of phenolic compounds that have an antihyperlipidemic effect. However, the phenolic compounds of figs have not been intensively studied. The purpose of this study was to determine the activity of phenolic compounds in figs as antihyperlipidemic in inhibiting the work of the HMG-CoA reductase enzyme. This research uses an experimental technique with the in silico method. The in-silico method was performed to predict the physicochemical, pharmacokinetic, toxicity, and molecular docking properties by comparing the phe

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Syam, Nindrahayu, Andi Ariyandy, Ika Yustisia, Sulfahri, and Yusfina. "IIn Silico Testing On The Activity Of Flavonol In Sterculia foetida Leaf As Natural Anti Hyperlipidemia Compounds." International Journal of Applied Biology 6, no. 1 (2022): 144–48. http://dx.doi.org/10.20956/ijab.v6i1.19918.

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This study aims to measure the biological activity of flavonols in the leaves of Sterculia foetida as an antihyperlipidemic drug. The chemical structure of flavonols contained in the leaves of Sterculia foetida was taken from the literature. The target protein used was 3-hydroxy 3-methylglutaryl coenzyme A reductase and the control was simvastatin. Water molecules have been removed with PyMol v2.5.2 Software. Docking between the target protein and flavonols was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds have greater potential for antihyper

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Dhingra, Dinesh, Deepak Lamba, Ramesh Kumar, Pashupati Nath, and Satyaprakash Gauttam. "Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase." ISRN Pharmacology 2014 (February 17, 2014): 1–9. http://dx.doi.org/10.1155/2014/243575.

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The present study was designed to investigate antihyperlipidemic activity of dried pulp of Aloe succotrina leaves in Wistar albino rats. Hyperlipidemia was induced in rats by feeding them high fat diet (HFD) or D-fructose (25% w/v) for 4 successive weeks. From 15th to 28th day, dried pulp (100 and 200 mg/kg, p.o) and atorvastatin (10 mg/kg, p.o.) per se were administered 2 h prior to feeding rats with HFD or fructose. Aloe succotrina did not significantly decrease the body weight of rats. The dried pulp and atorvastatin per se significantly decreased relative liver weight but did not significa

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Tung, Yu-Tang, Chieh-Hsi Wu, Wen-Chao Chen, et al. "Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats." Nutrients 14, no. 21 (2022): 4665. http://dx.doi.org/10.3390/nu14214665.

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Ascophyllum nodosum and Fucus vesiculosus both contain unique polyphenols called phlorotannins. Phlorotannins reportedly possess various pharmacological activities. A previous study reported that the activity of phlorotannin is strongly correlated with the normalization of metabolic function, and phlorotannins are extremely promising nutrients for use in the treatment of metabolic syndrome. To date, no study has explored the antihyperlipidemic effects of phlorotannins from A. nodosum and F. vesiculosus in animal models. Therefore, in the present study, we investigated the effects of phlorotann

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27

Rajesh, Asija, Singh Charanjeet, and Hemlata. "A Comprehensive Review on Antihyperlipidemic Activity of Various Medicinal Plants." International Journal of Current Pharmaceutical Review and Research 7, no. 6 (2016): 407–15. https://doi.org/10.5281/zenodo.12680268.

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Hyperlipidemia is the greatest hazard factor of coronary heart disease. At present allopathic antihyperlipidemic drugs havebeen associated with large number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relativelycontemptible and locally available. Medicinal plants are the “backbone” of traditional medicine so considered as goodsource of life for all people due to its wealthy therapeutic properties and being 100% natural. Medicinal plants areextensively used by majority of populations to treat various diseases and have high impact on the world&rsqu

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El-Helby, Abdel Ghany, and Mohamed Abdel-Wahab. "SYNTHESIS AND ANTIHYPERLIPIDEMIC ACTIVITY OF CERTAIN NICOTINIC ACID DERIVATIVES." Bulletin of Pharmaceutical Sciences. Assiut 28, no. 1 (2005): 57–69. http://dx.doi.org/10.21608/bfsa.2005.65233.

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Ruslin, Ruslin, Henny Kasmawati, Suriani Suriani, Sundar Ihsan, and Desi Sartina. "Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic." Indonesian Journal of Pharmaceutical Science and Technology 6, no. 3 (2019): 118. http://dx.doi.org/10.24198/ijpst.v6i3.21611.

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Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatol

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Tiwari, Pallavi, Anju Puri, Ramesh Chander, Geetika Bhatia, and Anup Kumar Misra. "Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives." Bioorganic & Medicinal Chemistry Letters 16, no. 23 (2006): 6028–33. http://dx.doi.org/10.1016/j.bmcl.2006.08.123.

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Kathiravan, Muthu K., Kapil D. More, Vikas K. Raskar, et al. "Synthesis and antihyperlipidemic activity of novel condensed 2-fluoromethylpyrimidines." Medicinal Chemistry Research 22, no. 9 (2013): 4286–92. http://dx.doi.org/10.1007/s00044-012-0263-z.

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Kalsait, Ravi P., Pramod B. Khedekar, Ashok N. Saoji, and Kishor P. Bhusari. "Isolation of phytosterols and antihyperlipidemic activity of Lagenaria siceraria." Archives of Pharmacal Research 34, no. 10 (2011): 1599–604. http://dx.doi.org/10.1007/s12272-011-1003-5.

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Sashidhara, Koneni V., Abdhesh Kumar, Manoj Kumar, Anuj Srivastava, and Anju Puri. "Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives." Bioorganic & Medicinal Chemistry Letters 20, no. 22 (2010): 6504–7. http://dx.doi.org/10.1016/j.bmcl.2010.09.055.

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Anggraini, Deni, Hulwa Salsabila, Salman Umar, Yufri Aldi, and Erizal Zaini. "Preparation and Characterization of a Eutectic Mixture of Fenofibric Acid and Nicotinic Acid and Evaluatuion of In Vivo Antihyperlipidemic Activity." Science and Technology Indonesia 7, no. 4 (2022): 514–21. http://dx.doi.org/10.26554/sti.2022.7.4.514-521.

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Fenofibric Acid (FA) is classified under Biopharmaceutical Classification System (BCS) class II due to its poorly soluble in water and high permeability. The present study aimed to prepare the eutectic mixture of FA with nicotinic acid (NA) and characterize its solid state properties and in vitro dissolution rate, along with its in vivo antihyperlipidemic activity. Solvent drop grinding was the method chosen to prepare the eutectic mixture of FA and NA. Solid-state properties were evaluated using thermal analysis Differential Scanning Calorimetry (DSC), crystallographic analysis Powder X-Ray D

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Y., Anil Kumar *. Konda Ravi Kumar K.Subrahmanyam. "ANTIHYPERLIPIDEMIC ACTIVITY OF CISSUS QUADRANGULARIS STEM EXTRACTS IN FRUCTOSE INDUCED AND TRITON-INDUCED HYPERLIPIDEMIC RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 09 (2018): 8877–83. https://doi.org/10.5281/zenodo.1421345.

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<em>Hyperlipidemia is a disorder of lipid metabolism which is major risk of coronary heart disease. Now day’s synthetic drugs have been associated with number of side effects but herbal medicines have lipid lowering and antioxidant activities without any side effects. Some traditionally herbs like: - Terminalia Arjuna (Arjun), Commiphora mukul (Gugglul), Picrorrhiza Kurroa(Kutki), Allium Sativum (Lasuna), etc. are used as Antihyperlipidemic drug as per ayurvedic literature. The review article is undertaken to investigate the herbal Plants for Antihyperlipidemic activity and models use in

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Nugraha, Dyan Fitri, Noval Noval, and Kunti Nastiti. "Uji Aktivitas Teh Celup Fraksi Metanol Rimpang Temu Mangga (Curcuma mangga Valeton and Zijp) sebagai Antihiperlipidemia." Jurnal Surya Medika 7, no. 2 (2022): 20–26. http://dx.doi.org/10.33084/jsm.v7i2.3199.

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The high number of deaths from cardiovascular disease in the world makes cardiovascular drugs, such as antihyperlipidemic or dyslipidemia often used by patients in the whole world. Statins are first-line drugs that are often used, but have various side effects, such as myalgia, rhabdomyolysis, and are considered to trigger diabetes mellitus. Meanwhile, the use of traditional medicines such as the Temu mangga’s rhizome (Curcuma mangga Valeton and Zijp) is often used by the community as antihyperlipidemic therapy. The purpose of this study was to scientifically prove the antihyperlipidemic activ

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Raharjo, Danang, Anna Fitriawati, and Muhhamad Aminnulloh. "AKTIVIITAS ANTIOKSIDAN ANTIHIPERLIPIDEMIA DAN ANTIHIPERTENSI DARI EKSTRAK ETANOL DAUN KEDABU (Sonneratia ovata. Backer)." JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan 10, no. 1 (2025): 67–79. https://doi.org/10.36387/jiis.v10i1.2245.

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Kedabu (Sonneratia ovata. Backer) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. The flavonoid content in the kedabu plant includes sonnerphenolic, vanillin, (-)-(R)-nyasol, (-)-(R)-4’-O-methylnyasol, maslinic acid, lingueresinol and gallic acid. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This

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Josiane, Ngatchic Metsagang Therese, Douanla Nodem Forestine Nikaise, Ndjantou Elie Baudelaire, and Njintang Yanou Nicolas. "Lipid-lowering and anti-lipase properties of powder fractions of Dichrostachys glomerata fruits." Asian Journal of Medical Sciences 11, no. 5 (2020): 69–76. http://dx.doi.org/10.3126/ajms.v11i5.29229.

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Background: Fruits of Dichrostachys glomerata have in the last ten years benefited from special attention as a lipid-lowering plant. Recent studies show that biological activities of some plants depend on granulometry of their powder particles. Aims and Objective: The purpose of this study was to assess antihyperlipidemic, hypolipidemic, and anti-lipase properties of powder fractions of the fruits of Dichrostachys glomerata. Materials and Methods: The groups of rats on which the antihyperlipidemic test was done were fed with High Fat Diet and supplemented with powder fractions: ≥18

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Alyahya, AbdulRahman A. I., Mohammed Asad, Mohammed Alrouji, Kamal Eldin Ahmed Abdelsalam, Adel Mashan Rashed Al-Mutairi, and Monjid Ahmed Ibrahim Ahmed. "Hypolipidemic and Antihyperlipidemic Effects of Holarrhena pubescens Methanolic Extract Is Mediated through Inhibition of Lipase Activity and Lipid Accumulation." Life 13, no. 7 (2023): 1435. http://dx.doi.org/10.3390/life13071435.

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Holarrhena pubescens seeds are used in the treatment of various diseases, especially diabetes and associated complications, in different parts of the world. The present study was undertaken to determine the hypolipidemic and antihyperlipidemic effects of methanolic extract of H. pubescens seeds in rats. The extract was subjected to LC-MS analysis to determine the chemical constituents. The hypolipidemic action was studied by determining the effect of 28-day oral administration of seed extract on serum cholesterol, serum triglycerides, and serum HDL-cholesterol levels. The antihyperlipidemic ac

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Kumari, Priyanka, Satish Kumar Sharma, and Snigdha Tiwari. "Evaluation of antihyperlipidemic and antioxidant activity of Rubia Cordifolia Linn." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 211–15. http://dx.doi.org/10.22270/jddt.v9i1.2216.

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Hyperlipidemia is major problem among population those, who have sedentary life style. The effects of ethanolic and aqueous root extract of Rubiacordifoliain experimentally induced hyperlipidemic rats were investigated. 42 wistar rats of both sexes were used for the study. The animals were completely randomized into seven groups comprising 6 animals each. The groups were treated as follows: Group I: normal diet (ND); Group II: HFD ( Vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day); Group III: HFD + Atorvastatin (10 mg/kg/day); Group IV: HFD+ ethanolic extract of roots of R

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Guptha, B. H. M. R. K., S. L. D. V. Ramana Murty Kadali, Vijay Kumar M., and Revanasiddappa B. C. "Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 518. http://dx.doi.org/10.18203/2319-2003.ijbcp20180667.

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Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio-metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important.Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton W

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Pande, VV, and Sonal Dubey. "Antihyperlipidemic activity ofSphaeranthus indicuson atherogenic diet induced hyperlipidemia in rats." International Journal of Green Pharmacy 3, no. 2 (2009): 159. http://dx.doi.org/10.4103/0973-8258.54911.

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Shukr, Marwa H., Soha Ismail, and Samya Mahmoud Ahmed. "Development and optimization of ezetimibe nanoparticles with improved antihyperlipidemic activity." Journal of Drug Delivery Science and Technology 49 (February 2019): 383–95. http://dx.doi.org/10.1016/j.jddst.2018.12.001.

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Lyan Nurlianti Lutfiah, Yani Lukmayani, and Livia Syafnir. "Potensi Tumbuhan Jintan Hitam (Nigella sativa Linn.) sebagai Antihiperlipidemia." Bandung Conference Series: Pharmacy 4, no. 2 (2024): 193–200. http://dx.doi.org/10.29313/bcsp.v4i2.13513.

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Abstract. Black cumin (Nigella sativa Linn.) is a plant that is useful as an antihyperlipidemic agent. Hyperlipidemia is a major risk factor for atherosclerosis. The research method used in this literature review is a literature search online databases. The results of the literature search indicate that black cumin has the potential as an antihyperlipidemic with the administration of extracts and essential oils. Absolute ethanol solvent and a mixture of methanol and distilled water are the best solvents. Between extracts and essential oils, extracts are proen to be more effective than essentia

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Vaishnavi, M. Walhekar* Vaishnavi Bathe Vaishali Kadam Shital Rokade. "Review On Embelia Ribes And It's Pharmacological Activity." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 1312–19. https://doi.org/10.5281/zenodo.11092906.

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Embelia ribes is a kind of Embelia. Burm. F. Is a member of the Myrsinaceae family, which grows in Hilly areas of India up to 1500 metres in elevation, from the outer Himalayas to the Western Ghats. Embelia ribes Burm. F. Is a rare medicinal plant that has been studied extensively for its diverse Medicinal characteristics. The use of medicinal plants in therapeutics is perhaps as old as recorded History. Embelia ribes is one of most significant medicinal plant. Nearly each part of this plant contains Varied chemical constituents and is utilized within the treatment of various. Broad inquire ab

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He, Kai, Xuegang Li, Yubo Xiao, et al. "Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice." Food & Function 7, no. 8 (2016): 3505–15. http://dx.doi.org/10.1039/c6fo00623j.

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The present study evaluated the antihyperlipidemic activity of myricetin, myricetrin, the alcohol fraction (AF) and the ethyl acetate fraction (EF) obtained from the bark of Myrica rubra (MR) in high-fat and high-cholesterol (HFHC) induced hyperlipidemic C57BL/6j mice.

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Mansoury, Manal. "A Review of the Antidiabetic, Antihyperlipidemic, and Related Metabolic Disorder Documented Activities of Emblic Fruits (Phyllanthus emblica L.)." Journal of Complementary Medicine Research 14, no. 1 (2022): 1. http://dx.doi.org/10.5455/jcmr.2022.13.05.01.

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Diabetes is a risky metabolic chronic sickness that threatens the lives and health of individuals, families, and communities everywhere. Management of diabetes and related metabolic syndrome (MS) relies heavily on diet. There are reports of folk plants showing varying levels of antihyperglycemic activity. Phyllanthus emblica Linn (syn. Emblica officinalis) (often referred to Emblic, Indian gooseberry, or amla) is a perennial tree in the Euphorbiaceae family. Due to the high concentration of phenolic compounds, Emblic fruit may be considered a plant source of natural antioxidants. Numerous stud

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Hasan, S. M. Fahim, Ikram Wahid Toha, Md Effadul Islam Econ, et al. "Exploring the Antihyperlipidemic Properties of Piper nigrum." Asian Journal of Advanced Research and Reports 19, no. 2 (2025): 372–78. https://doi.org/10.9734/ajarr/2025/v19i2914.

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Humans have used herbal medicine to address medical conditions since the inception of civilization. This study seeks to assess the effectiveness of Piper nigrum as an anti-hyperlipidemic drug and its influence on lipid profiles. We utilized the model to evaluate the effectiveness of the plant antihyperlipidemic activity. SGPT and SGOT levels were statistically significantly reduced (p < 0.05) in groups 6 and 5, respectively, at doses of 900 mg/kg and 600 mg/kg. No groups demonstrated statistically significant results in the renal function test. Despite a slight reduction in total cholestero

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Kausar, Fatima* Konde Abbulu. "ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF CHONEMORPHA FRAGRANS AND ERYTHROXYLUM MONOGYNUM COMBINED ETHANOLIC LEAF EXTRACT IN ALLOXAN INDUCED DIABETIC WISTAR RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7428–36. https://doi.org/10.5281/zenodo.1006785.

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The objective of the present study was to evaluate the antidiabetic and antihyperlipidemic activity of herbal formulation containing Chonemorpha fragrans and Erythroxylum monogynum in alloxan induced diabetic rats. Diabetes mellitus is a group of syndrome characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular diseases. Hyperlipidemia constitutes a major etiopathological factor for atherosclerosis. The preliminary phytochemical screening shows the presence of alkaloids, glycosides, carbohydrates, flavonoids,

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Ejiroghene, Ahante, G. Moke Emuesiri, K. Anachuna Kenneth, M. Osifo Itohan, S. Nworu Chukwuemeka, and A. Akah Peter. "An Investigation of the Antihyperlipidemic and Antioxidant Activities of the Crude Extract and Fractions of Phaseolus vulgaris Linn on Experimental Rats." Pharmaceutical and Chemical Journal 4, no. 4 (2017): 66–78. https://doi.org/10.5281/zenodo.13785030.

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This research aimed at investigating the antihyperlipidemic and antioxidants activities of the crude extract and fractions of <em>Phaseolus vulgaris Linn</em>. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended in aqueous medium and solvents of increasing polarity to obtained the n-hexane fraction (PVHF), ethylacetate fraction (PVEF), and butanol fraction (PVBF) in that order. Acute, sub-acute a

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