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Journal articles on the topic 'Antihypertensive Drug Delivery'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chawra, Himmat Singh, Y. S. Tanwar, Ritu M. Gilhotra, and S. K. Singh. "Gastroretentive drug delivery systems a potential approach for antihypertensive drugs: An updated review." Asian Pacific Journal of Health Sciences 5, no. 2 (2018): 217–23. http://dx.doi.org/10.21276/apjhs.2018.5.2.40.

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2

Chauhan, Neeraj K., Anuj Malik, and Paramjeet K. Ratiyen. "Solid Lipid Nanoparticles: Drug Delivery Systems for Enhancing the Bioavailability of Antihypertensives." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 1059–64. http://dx.doi.org/10.25258/ijddt.13.3.46.

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The pharmaceutical industry focuses the SLNs as promising drug deliverance methods for improving bioavailability. SLNs are a swiftly budding field of nanotechnology amid plentiful budding applications in medicine and research. Lipid-based nanoparticles possess unique properties due to their small size, allowing novel therapeutics to be developed. The encapsulation of drugs within nano-carriers presents a new paradigm in drug delivery, enabling enhanced targeting at secondary and tertiary levels. Consequently, SLNs have garnered significant attention from researchers for their site-specific dru

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3

Pal, Pawan Chandrashekhar* Mrityunjay Kumar Yasir Akhbar Dar Faizan Jeelani Shergojri Nauneet Kumar Satyam Gulwani. "Preparation And Characterization of Microencapsulating Drug Delivery Systems of Few Anti-Hypertensive Drugs." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3614–19. https://doi.org/10.5281/zenodo.15480350.

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The present study focuses on the preparation and characterization of microencapsulated drug delivery systems for selected antihypertensive agents. Microencapsulation is an advanced drug delivery approach that enhances the pharmacokinetic profile, stability, and controlled release of therapeutic agents. In this project, various antihypertensive drugs—such as amlodipine, atenolol, and enalapril cellulose and sodium alginate via techniques such as solvent evaporation and ionic gelation. The goal of developing microencapsulating drug delivery systems (DDS) for antihypertensive treatments is

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4

KIRAN, KULKARNI SACHIN LOKAPURE AMRUTA TIDAKE. "A BRIEF REVIEW ON ROLE OF NANOCARRIER AS ANTIHYPERTNESIVE AGENTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6973–87. https://doi.org/10.5281/zenodo.2619939.

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Now days Hypertension or high blood pressure is a common chronic heart disease. It is associated with various symptoms like amnesia, improper speech, blindness, peripheral artery disease, brain stroke, heart attack etc. it mainly involves the role of autonomous nervous system, cardiac output and renin-angiotensin aldosterone system. The present study mainly deals with the application of nanotechnology and nanoparticulate drug delivery systems in the formulation of various antihypertensive drugs for the treatment of hypertension. Applications of various nanoparticulate drug delivery systems lik

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Soni, Nikita, Deepak Joshi, Vikas Jain, and Pradeep Pal. "A Review on Applications of Bilayer Tablet Technology for Drug Combinations." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 222–27. http://dx.doi.org/10.22270/jddt.v12i1.5206.

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Bilayer tablets are novel drug delivery systems where combination of two drugs in a single unit having different release profiles can be delivered. Bilayer tablets improve patient compliance, prolong the drug(s) action and can deliver two incompatible drugs in a single formulation. Bilayer tablets have one layer of active ingredient for immediate release and a second layer for delayed release, either as a second dose or in an extended release fashion. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology i

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6

ELLIOTT, W. "Drug delivery systems for antihypertensive agents." American Journal of Hypertension 9, no. 4 (1996): 201A. http://dx.doi.org/10.1016/0895-7061(96)82173-x.

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7

Harshda, Pandiya, and Shekhar Sharma Chandra. "A Review on Gastroretentive Drug Delivery System of Antihypertensive Drugs." Pharmaceutical and Chemical Journal 8, no. 3 (2021): 51–76. https://doi.org/10.5281/zenodo.13962560.

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Oral drug administration is also the favored method of drug administration. GRDDSs are a novel approach in the Pharmaceutical Industry (Gastroretentive Drug Delivery System). Dosage forms that can be retained in the stomach are called GRDDs. By continually releasing the drug for a long period of time until it reaches its absorption site, GRDDSs can enhance the regulated release of drugs with an absorption window. GRDDS are thus favourable for such drugs by improving their bioavailability, therapeutic effectiveness, and the possibility of dose reduction, as well as improving drug solubility, wh

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8

Sandeep, Kumar, and Rakesh Kumar Meel Dr. "A Review on Recent Research in Drug Targeting using Gastroretentive Drug Delivery Systems for Antihypertensive Drugs." Pharmaceutical and Chemical Journal 10, no. 3 (2023): 102–11. https://doi.org/10.5281/zenodo.13995572.

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The preferred route of drug administration is via the oral route. Gastroretentive Drug Delivery Systems (GRDDSs) represent an innovative strategy within the pharmaceutical sector. Gastroretentive drug delivery systems (GRDDs) refer to dosage forms that are designed to remain in the stomach for an extended period of time. Gastroretentive drug delivery systems (GRDDSs) have the potential to improve the controlled release of drugs that have a specific absorption window by gradually administering the drug over an extended period until it reaches the intended site of absorption. The use of GRDDS is

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9

Abhay, Mane1* Pritam Salokhe 2. Nilesh Chougule3. "The Medical Survey Of An Antihypertensive Drugs." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1529–54. https://doi.org/10.5281/zenodo.12790440.

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Over the past three decades, formulation technology has significantly advanced, particularly in drug delivery systems. Innovations include novel dosage forms and new uses for existing drugs, offering benefits like improved patient compliance, sustained drug concentration, reduced dosing frequency, targeted delivery, and minimized side effects. Transdermal drug delivery systems (TDDS) are key developments, allowing controlled, continuous medication administration through the skin, bypassing gastrointestinal degradation and hepatic first-pass metabolism, and enhancing bioavailability and patient

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10

Khalid, Ramsha, Syed Mahmood, Zarif Mohamed Sofian, Ayah R. Hilles, Najihah Mohd Hashim, and Yi Ge. "Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review." Pharmaceutics 15, no. 8 (2023): 2029. http://dx.doi.org/10.3390/pharmaceutics15082029.

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One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides,

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11

Sharma, Mayank, Rajesh Sharma, and Dinesh Kumar Jain. "Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs." Scientifica 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/8525679.

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Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these sy

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12

Bidkar, Shital, Akshada Tandale, Abhishek Meher, Jayant Bidkar, and Ganesh Dama. "Overview of Antihypertensive Transdermal Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1640–45. http://dx.doi.org/10.25258/ijddt.13.4.78.

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In order to boost bioavailability and enhance patient compliance, this review focuses on the antihypertensive action of transdermal patches. Using a transdermal method for administering medication (TDDS), it is possible to administer a systemic medicament via a simple skin patch. Among the most prevalent human diseases is hypertension. There is a strong correlation between hypertension and cardiovascular mortality and morbidity. The evolution of skin science, innovation, and experience that led to these patches began with the earliest written records of human history and continues to this day

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13

Suryakant Shrivastava, Manoj Goyal, and Arti Soni. "Gastro-retentive drug delivery system of hypertension drug: Formulation and evaluation study." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2094–105. http://dx.doi.org/10.30574/wjarr.2024.23.2.2512.

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Introduction: Hypertension, a major global health concern, necessitates effective management through sustained drug delivery systems. Gastro-retentive drug delivery systems (GRDDS) offer a strategic advantage by prolonging the residence time of drugs in the stomach, thus enhancing therapeutic efficacy and patient adherence. This study aims to develop and evaluate a GRDDS for antihypertensive drugs to achieve extended gastric retention and controlled release. Methods: A GRDDS was formulated using a combination of hydrophilic and hydrophobic polymers to ensure buoyancy and extended gastric reten

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14

Suryakant, Shrivastava, Goyal Manoj, and Soni Arti. "Gastro-retentive drug delivery system of hypertension drug: Formulation and evaluation study." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 2094–105. https://doi.org/10.5281/zenodo.14874315.

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<strong>Introduction: </strong>Hypertension, a major global health concern, necessitates effective management through sustained drug delivery systems. Gastro-retentive drug delivery systems (GRDDS) offer a strategic advantage by prolonging the residence time of drugs in the stomach, thus enhancing therapeutic efficacy and patient adherence. This study aims to develop and evaluate a GRDDS for antihypertensive drugs to achieve extended gastric retention and controlled release. <strong>Methods: </strong>A GRDDS was formulated using a combination of hydrophilic and hydrophobic polymers t

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15

Kamat, Grusha, Kunal Naidu, Shweta Pandey, Renu Kunkekar, and Rutuja Jadhav. "Formulation and Evaluation of Candesartan Cilexetil 4mg Transdermal Patch." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 87–96. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.008.

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Transdermal patches containing antihypertensive drugs are preferable to conventional-dose forms because they minimize administration frequency, are less intrusive, and cause no gastrointestinal upset. Candesartan is an angiotensin-converting enzyme inhibitor that can be used alone or in combination with other drugs to treat hypertension. It may also be used as an alternative agent for the treatment of heart failure, myocardial infarction, and coronary artery disease. A transdermal patch is superior to oral administration as it avoids first past metabolism and delivers the drug for a prolonged

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16

Hameed, Huma, Arwa Khalid, Fazala Khalid, Rabeea Khan, and Akhtar Rasul. "Chrono pharmacotherapy: A pulsatile Drug Delivery." Pakistan Journal of Pharmaceutical Research 1, no. 1 (2015): 25. http://dx.doi.org/10.22200/pjpr.2015125-32.

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Chronopharmacotherapy refers to a treatment in which controlled drug delivery is achieved according to circadian rhythms of disease by enhancing therapeutic outcomes and minimizing side effects. Colon targeting has gained great importance not only for the treatment of local diseases such as Crohn’s disease, inflammatory bowel disease and ulcerative colitis but also very important in systemic delivery of proteins/peptides, antiasthmatic drugs, antidiabetic agents and antihypertensive drugs, which mostly show their efficacy based on circadian rhythms of the body.Colon drug delivery is one of the

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17

Shivam, Pandey, Hariom Sharma Dr., and Singh Jaya. "Review on Novel Drug Delivery System and Antihypertensive Tablets." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1283–86. https://doi.org/10.5281/zenodo.3590981.

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Novel drug delivery system offers excellent opportunity to the inventors for developing new technologies for drug administration, dispersible tablets are come under this category as it offers various advantages over conventional tablets. Dispersible tablets offer rapid disintegration in the mouth while came in contact with saliva. It is good find and rapid solution for the problem of dysphasia among geriatrics, as they feel some problem in swallowing a tablet. This article discuss about dispersible tablets, dysphasia, advantages and disadvantages of dispersible tablets. It also discuss about h

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18

Arunkumar, Selvi, L. Srinivas, D. Satyavati, and C. Emmanuel. "Comparative Study of Antihypertensive Drugs Amlodipine Besylate /Metoprolol Succinate and Nebivolol Hydrochloride /Valsartan Combinations in Bilayer Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 529–39. http://dx.doi.org/10.22270/jddt.v9i4-s.3214.

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The present research is an approach to develop a formulation platform that shall help in minimizing the time and effort taken to develop a drug delivery system. Taking bilayer tablet technology as a representation for drug delivery system, well accepted antihypertensive drugs, Amlodipine besylate and Metoprolol succinate were considered as model drugs for the study. Initially the process variables like concentration of the disintegrants, Sodium starch Glycolate and cross carmellose sodium, Polymers HPMC K100M and K4M were standardized with these drugs so that the incorporation of a new combina

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19

Bhanushali, Roopali, Rajeshri Wakode, and Amrita Bajaj. "Monolithic Osmotic Tablets for Controlled Delivery of Antihypertensive Drug." Journal of Pharmaceutical Innovation 4, no. 2 (2009): 63–70. http://dx.doi.org/10.1007/s12247-009-9055-5.

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20

Darisi, Saketh1 Gangolu Yohan2 Gurram Lokeswari3 Bodapati Meghana4 Jayanth Kandula5 Dr. Rama Rao Vadapalli6*. "Analyzing Antihypertensive Drugs Floating Times for Efficiency Evaluation: A Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1801–15. https://doi.org/10.5281/zenodo.15049315.

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Objective: This review aims to evaluate the efficacy of Gastroretentive Drug Delivery Systems (GRDDS) in enhancing the gastric residence time of antihypertensive drugs to improve drug absorption and bioavailability. Methods: The study analyzed various GRDDS formulations designed to prolong gastric residence time. Key parameters such as Total Floating Time and Floating Lag Time were measured to assess the sustained release capabilities of these formulations. A comparative analysis was conducted across different antihypertensive drugs, focusing on their floating capacities in simulated gastric f

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Ruchiket, K. Jagtap Manisha Savle Gajanan Sanap. "A Review On Colon Targeted Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 152–64. https://doi.org/10.5281/zenodo.10494997.

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Day by day, advancements in the field of colon-specific drug delivery continue to emerge. The delivery of drugs directly to the colon is increasingly important, not only for treating local colon-related ailments like Crohn’s disease and ulcerative colitis but also for administering proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive medications, and anti-diabetic agents systemically. Recent advancements have led to the development of new systems and technologies aimed at targeting the colon and surpassing the limitations of previous methods. Despite its promising poten

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22

Janugade, Bhagyesh U., and Neelam Singla. "Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 61–68. http://dx.doi.org/10.25258/ijpqa.15.1.09.

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The current research aimed to prepare and estimate bioadhesive pulsatile drug delivery system (BPDDS) of an antihypertensive drug, losartan potassium, containing the formulation of a fast-dissolving core tablet and a combination of core tablet to polymer coating to formulate (BPDDS) tablet through a direct compression procedure. The coating was completed by utilizing polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was entirely assessed for the formulations. Altogether, estimation tests were found to

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23

Sardesai, Mrunmayi, and Pravin Shende. "Engineering of Nanospheres Dispersed Microneedle System for Antihypertensive Action." Current Drug Delivery 17, no. 9 (2020): 776–86. http://dx.doi.org/10.2174/1567201817666200804110003.

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Background: A combinational therapy is mostly preferred in hypertension treatment because of low-dose and less side effects like pretibial edema, and gastrointestinal bleeding. Objective: So the objective of the present work was to formulate an advanced drug delivery system in the form of bio-responsive microneedles by incorporating nifedipine, a cardiodepressant and diltiazem, a vasodilator for effective synergism in the treatment of hypertension. Methods: The pH-responsive PLGA nanospheres of diltiazem were formulated using Water-in-Oil-in- Water (W/O/W) double emulsion and solvent-diffusion

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Gaurav, Pandole* Vikas Kumar Dr. Jitendra Banweer. "Role of Transdermal drug delivery System in the Treatment of Hypertension." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1844–58. https://doi.org/10.5281/zenodo.15386527.

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Hypertension continues to be a major contributor to cardiovascular diseases and deaths globally, impacting almost one billion people. While conventional oral treatments are effective, they face limitations such as poor bioavailability, short durations of action, and the necessity for frequent dosing. These factors lead to fluctuating plasma drug levels and decreased patient adherence to prescribed therapies. To address these challenges, Transdermal Drug Delivery Systems (TDDS) have been explored as a promising solution for the controlled and sustained administration of antihypertensive drugs.

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Vaclavik, Jan, Zdenek Ramik, Jiri Jarkovsky, Radka Pohlova, Jitka Jirova, and Anna Zouharova. "O22 MATERNAL AND FETAL OUTCOMES OF VARIOUS ANTIHYPERTENSIVE TREATMENT REGIMENS DURING PREGNANCY: INSIGHTS FROM THE CZECH NATIONAL REGISTRY 2012-2022." Journal of Hypertension 42, Suppl 3 (2024): e10-e11. http://dx.doi.org/10.1097/01.hjh.0001062556.92194.cf.

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Introduction: Arterial hypertension affects about 5-10% of pregnancies and has detrimental effects on pregnancy outcomes in both the mother and fetus. This study aimed to analyze the outcomes of pregnancy in women treated with different antihypertensive drugs. Methodology: Nationwide data on all births and abortions in the period 2012-2022 in the Czech Republic were obtained from the National Registry of Reproductive Health (NRRZ) and the National Registry of Reimbursable Health Services (NRHZS). Women who had the diagnosis I10 within one year before pregnancy and were prescribed any antihyper

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AMGAONKAR, YOGESH. "Formulation Development and Evaluation of Transdermal Drug Delivery System of Antihypertensive Drug." Research Journal of Pharmacy and Technology: 3, no. 3 (2010): 753–57. https://doi.org/10.5281/zenodo.10208766.

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27

Saniya, Ikra Khan* Anjali Chourasiya Vikas Jain Narendra Gehalot. "A Review Article On Transdermal Patches Of Atenolol For Management Of Hypertension." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3638–51. https://doi.org/10.5281/zenodo.13367089.

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A key risk factor for cerebrovascular accidents, heart disease, and death is hypertension. In developing nations, the prevalence of hypertension and cardiovascular illnesses is rising quickly. β-blockers are a significant class of antihypertensives, among many other types. After oral treatment, the majority of β-blockers undergo hepatic first-pass metabolism, which results in limited bioavailability. Due to their short half-lives, they must be taken more than once a day. Because of this, when conventional oral dosage forms like tablets and capsules are administered more than once a d

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Mahari, Samar, Seydeh Halimeh Najafi, Salar Masoomzadeh, Shalen Kumar, and Tooba Gholikhani. "A Review of Osmotic Pump Applications as a Reliable Drug Delivery System in Pharmaceutical Sciences." Biomedical Research Bulletin 2, no. 1 (2024): 29–36. http://dx.doi.org/10.34172/biomedrb.2024.05.

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Systems known in the pharmaceutical sciences have less use for drug release and control. In addition, these standard systems in pharmacy have no effective control over drug concentrations. The main problem with conventional drug delivery systems (DDS) is the unpredictability of different plasma concentrations. However, drug control systems have provided an excellent way to release the drug. In this regard, osmotic pumps are the best and most promising systems for the controlled delivery and release of drugs. They are commonly used for oral and injectable use, several of which are also commerci

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Al Ismaili, Al-khatab, Tamima Al-Duqhaishi, Hajar Al Rajaibi, et al. "Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital." Oman Medical Journal 37, no. 2 (2022): e354-e354. http://dx.doi.org/10.5001/omj.2022.43.

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Objectives: We sought to identify the most commonly used antihypertensive medications in pregnant women and to determine the impact of these medications on perinatal (maternal and fetal) outcomes. Methods: The medical records of 484 hypertensive pregnant women who attended a tertiary university hospital during the study period were retrospectively evaluated for eligibility. Singleton pregnancies of women on antihypertensive medications and who delivered in the hospital were included in the study. Results: A total of 210 women (mean age of 32.4±5.6 years and mean body mass index of 34.0±8.1 kg/

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Velusamy, Sivakumar. "COMPARISON OF TREATMENT OUTCOME OF ANTIHYPERTENSIVE DRUGS IN THE MANAGEMENT OF PREGNANCY INDUCED HYPERTENSION." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 3 (2017): 287. http://dx.doi.org/10.22159/ijpps.2017v9i3.15889.

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This study was aimed to find out the differences in the pregnancy outcome of PIH women treated with the antihypertensive drugs methyldopa and nifedipine. The prospective observational study was conducted in a multi specialty hospital at Coimbatore with 161 PIH diagnosed women. Women were categorised into the no-drug group, methyldopa group, nifedipine group and methyldopa with nifedipine group. All the women were monitored from diagnosis to delivery. The maternal and neonatal data were collected and analysed. The drugs were significantly controlled the blood pressure (BP) from base to end (P&l

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Shinde, Shital A., Dipak P. Mali, Vandana M. Thorat, and Ankita D. Walgude. "Integrative Approaches in Hypertension Management: A Review of the Combination of Allopathic Drugs and Herbal Medicines in Drug Delivery Systems." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–14. https://doi.org/10.25258/ijddt.15.2.59.

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Hypertension remains an important worldwide fitness distress, requiring development of integrative medicinal approaches to improve action outcomes. This review explores the synergistic combination of allopathic antihypertensive drugs and herbal medicines within drug delivery systems (DDS) to improve efficacy, minimize adverse effects, and optimize patient adherence. By leveraging modern DDS technologies such as controlled-release systems, nano formulations, and liposomes, the bioavailability and targeted delivery of both pharmaceutical and herbal compounds can be significantly enhanced. The re

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M., Roshni* Roopesh P. T. Sandra S. Anagha Mohan Megha V. S. Haritha K. And Sindhu V. "Transdermal Patches For The Treatment Of Hypertension." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 2106–20. https://doi.org/10.5281/zenodo.13124965.

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One of the crucial diseases that kills people worldwide is hypertension. As a chronic illness, therapy must be given over an extended period of time. Antihypertension medications are a great fit for transdermal drug delivery systems due to their drawbacks, which include larger frequency of administration, significant first-pass metabolism, and variable bioavailability. The present article aims to study transdermal antihypertensive patches with the goal of increasing bioavailability and patient compliance. Among the several medications are indapamide, furosemide, eplerenone, captopril, enalapri

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Kumar, Lalit, and Puneet Utreja. "Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review." Recent Patents on Nanotechnology 14, no. 3 (2020): 193–209. http://dx.doi.org/10.2174/1872210514666200519071734.

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Background: Hypertension comes under the category of chronic disease, which requires long term treatment. Hypertension is usually treated by oral administration of various therapeutic agents. There are several limitations of the oral route, making pharmaceutical scientists to discover an alternative route for drug delivery. Methods: The transdermal route may be a better alternative as it shows various advantages like lack of first-pass effect and high patient compliance. The skin may act as a primary barrier for the transdermal delivery of anti-hypertensive drugs; therefore, new approaches are

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Thangam, C., Rozario Cyril, R. Jayasree, Y. Santhosh Kumar, Langeswaran Kulanthaivel, and Gowtham Kumar Subbaraj. "Enhancement of Oral Bioavailability of Drugs through Nanotechnology: Comprehensive Review and Meta-Analysis." Journal of Preventive, Diagnostic and Treatment Strategies in Medicine 2, no. 4 (2023): 187–93. http://dx.doi.org/10.4103/jpdtsm.jpdtsm_116_23.

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In terms of drug delivery methods, oral administration stands out as the preferred option, as it ensures better patient compliance. However, the challenges of poor water solubility and limited metabolic/enzymatic stability hinder the effectiveness of oral drug delivery. Nanotechnology-based drug delivery systems offer promising solutions to overcome these barriers and enhance oral medication delivery. They provide an avenue for administering antihypertensive drugs with improved therapeutic impact and bioavailability. To compile information on enhancing oral bioavailability through nanotechnolo

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Dole, Radhika, Daniel Kothapally, Sampoorna Chukkala, and Ravi Chander Thatipelli. "Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 73–77. http://dx.doi.org/10.22270/jddt.v13i5.5814.

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Hypertension elevates the risk of heart disease and stroke which are one of the most frequent causes of death. Fortunately, hypertension is manageable with the use of anti-hypertensives and a healthy lifestyle. However, patient non-adherence to the prescribed dosing regimen is the primary reason for uncontrolled blood pressure levels. Daily multiple doses of medication are one of the major reasons for patient non-compliance to the dosing regimen. Multiple doses of medication are a result of low solubility and high first-pass metabolism of anti-hypertensives. There are several approaches to imp

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Chontzopoulou, Eleni, Andreas G. Tzakos, and Thomas Mavromoustakos. "On the Rational Drug Design for Hypertension through NMR Spectroscopy." Molecules 26, no. 1 (2020): 12. http://dx.doi.org/10.3390/molecules26010012.

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Antagonists of the AT1receptor (AT1R) are beneficial molecules that can prevent the peptide hormone angiotensin II from binding and activating the specific receptor causing hypertension in pathological states. This review article summarizes the multifaced applications of solid and liquid state high resolution nuclear magnetic resonance (NMR) spectroscopy in antihypertensive commercial drugs that act as AT1R antagonists. The 3D architecture of these compounds is explored through 2D NOESY spectroscopy and their interactions with micelles and lipid bilayers are described using solid state 13CP/MA

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Marri, Ruthika Ratna Veni, Mandeti Nithisha, Mamidipalli Apurva, Raghavarapu Prasanthi, and Tirunagari Mamatha. "Formulation and In Vitro Evaluation of Niosomal Gel for The Topical Administration of Losartan Potassium." Journal of Drug Delivery and Therapeutics 14, no. 1 (2024): 41–48. http://dx.doi.org/10.22270/jddt.v14i1.6366.

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This study aims to develop and test a topical drug delivery system for antihypertensive activity using Losartan potassium-loaded niosomes. The niosomes were created using the traditional ether injection approach, with four formulations made using cholesterol as the lipid and varying quantities of surfactants such as span 80 and span 60. The different formulations underwent testing for FTIR, particle size, zeta potential, drug content, entrapment efficiency, and in vitro release. FTIR analysis revealed that the medication was incompatible with excipients. The study concludes by highlighting cur

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Astley, Cai, Chahinez Houacine, Azziza Zaabalawi, et al. "Nanostructured Lipid Carriers Deliver Resveratrol, Restoring Attenuated Dilation in Small Coronary Arteries, via the AMPK Pathway." Biomedicines 9, no. 12 (2021): 1852. http://dx.doi.org/10.3390/biomedicines9121852.

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Nanostructured lipid carriers (NLCs) are an emerging drug delivery platform for improved drug stability and the bioavailability of antihypertensive drugs and vasoprotective nutraceutical compounds, such as resveratrol (RV). The objective of this study was to ascertain NLCs’ potential to deliver RV and restore attenuated dilator function, using an ex vivo model of acute hypertension. Trimyristin–triolein NLCs were synthesized and loaded with RV. The uptake of RV-NLCs by human coronary artery endothelial cells (HCAECs) maintained their viability and reduced both mitochondrial and cytosolic super

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Azizi, Michel, Patrick Rossignol, and Jean-Sébastien Hulot. "Emerging Drug Classes and Their Potential Use in Hypertension." Hypertension 74, no. 5 (2019): 1075–83. http://dx.doi.org/10.1161/hypertensionaha.119.12676.

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Despite the availability of multiple antihypertensive drugs targeting the different pathways implicated in its pathophysiology, hypertension remains poorly controlled worldwide, and its prevalence is increasing because of the aging of the population and the obesity epidemic. Although nonadherence to treatment contributes to uncontrolled hypertension, it is likely that not all the pathophysiological mechanisms are neutralized by the various classes of antihypertensive treatment currently available, and, the counter-regulatory mechanisms triggered by these treatments may decrease their blood pre

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S, Sindhu, Dharani S, Bhavanitha V, and Pradhibha S. "PREPARATION AND CHARACTERIZATION OF NITRENDIPINE LOADED GRAFTED COPOLYMER MICROSPHERES: A PRELIMINARY STUDY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 126. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.23733.

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Objectives: Developing countries like India suffers mostly from cardiovascular problems and kidney failure. An antihypertensive drug is mainly used to avoid the cardiovascular problems and kidney failure. Nitrendipine is a calcium antagonist widely used in the treatment of hypertension. The bioavailability of drug, when administered orally, is low. Sustained drug delivery systems are using microspheres emerging as an effective method to increase the bioavailability of the drug. The current work involves the encapsulation of nitrendipine - acrylamide grafted chitosan which helps to overcome poo

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Hamzah, Mohammed Layth, Hanan J. Kassab, and Laith Hamza Samein. "Self-Nano Emulsifying Drug Delivery Systems." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4205–13. http://dx.doi.org/10.55522/jmpas.v11i1.1388.

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Lipid-based medication conveyance frameworks are widely announced in the writing for improving medication solvency, penetrability, and bioavailability. These frameworks incorporate straightforward oil arrangements, coarse, numerous, and dry emulsions, complex self-emulsifying, miniature emulsifying, or nano emulsifying drug conveyance frameworks. Self-emulsifying frameworks, further named self-miniature emulsifying drug conveyance frameworks (SMEDDS) and self-nano emulsifying drug conveyance frameworks (SNEDDS), are the most overall and economically feasible oil-based methodology for drugs tha

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Shyteyeva, Tatyana, Elena Bezchasnyuk, Oleg Kryskiv, and Vasyl Grynenko. "Substantiation of creation of transdermal forms of drug delivery with antihypertensive action." ScienceRise: Pharmaceutical Science, no. 4(44) (August 18, 2023): 104–13. http://dx.doi.org/10.15587/2519-4852.2023.286303.

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The article presents the theoretical justification for the choice of active pharmaceutical ingredients of antihypertensive action for the creation of new forms of delivery - transdermal therapeutic systems. Purpose: monitoring of studies on the use of angiotensin-converting enzyme (ACE) inhibitors in the development of transdermal drugs for the treatment of hypertension. Materials: open access electronic resources of scientific periodicals from around the world: Google Scholar (https://scholar.google.com/); PubMed (https://pubmed.ncbi.nlm.nih.gov/); Sciencedirect (https://www.scien

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Khairnar, Gokul, Vinod Mokale, Arun Mujumdar, and Jitendra Naik. "Development of nanoparticulate sustained release oral drug delivery system for the antihyperglycemic with antihypertensive drug." Materials Technology 34, no. 14 (2019): 880–88. http://dx.doi.org/10.1080/10667857.2019.1639019.

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Bialik, Maria, Marzena Kuras, Marcin Sobczak, and Ewa Oledzka. "Achievements in Thermosensitive Gelling Systems for Rectal Administration." International Journal of Molecular Sciences 22, no. 11 (2021): 5500. http://dx.doi.org/10.3390/ijms22115500.

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Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and uncomfortable to a patient, encouraging refusal. The limitations of conventional solid suppositories can be overcome by creating a thermosensitive liquid suppository. Unfortunately, there are currently only a few studies describing their use in ther

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Singh, Mangla Nand, Pushpa Yadav, Shubhini A. Saraf, Neha Katiyar, Ajeet Kumar Singh, and Indranil Yadav. "Formulation and Evaluation of Novel Sericin Nanoparticles for Buccal Delivery of Antihypertensive Drug." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 3, no. 01 (2018): 1–11. http://dx.doi.org/10.21477/ijapsr.v3i01.10421.

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The aim of this study is to prepare and evaluate sericin nanoparticles (NPs) of Verapamil Hcl which are finally formulated as buccal gel. It was envisaged to formulate the nanoparticles with gelatine, sericin and genipin. Nanoparticles incorporated gel was successfully prepared by using carbopol 934. Nanoparticles were prepared by dessolvation followed by crosslinking. Various parameters like drug content, viscosity, pH, spreadability and drug release were used to obtain the optimized formulation. The sericin nanoparticles incorporated gel shows better fast release as compare to API. The obtai

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Kumar, Choudhary Ram, Singh Gurinderdeep, Dev Dhruv, et al. "Proliposomal Dry Powder Inhalation: Design and Development for Pulmonary Antihypertensive Drug Delivery." International Journal of Zoological Investigations 10, no. 1 (2024): 589–95. http://dx.doi.org/10.33745/ijzi.2024.v10i01.064.

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Kasamolla, Indumathi Mohammed Mubeen Pasha J. Chandrudu*. "FORMULATION AND EVALUATION OF TRANSDERMAL DELIVERY SYSTEM COMPRISING CAPTOPRIL AS ANTIHYPERTENSIVE DRUG." Journal of Pharma Research 08, no. 12 (2019): 739–43. https://doi.org/10.5281/zenodo.7625760.

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Captopril was the first ACE inhibitor used for the treatment of hypertension. The present study was aimed to design and evaluate a matrix-type transdermal formulation containing captopril with different ratios of hydrophilic (Hydroxy propyl methyl cellulose E-15) and hydrophobic polymeric (Eudragit RS100) combinations plasticized with glycerin by the solvent evaporation technique. Effect of permeation enhancers such as oleic acid, dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) were studied. The interference of the polymers was ruled out by FT-IR studies. The prepared patches were teste

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Janugade, Bhagyesh U., and Neelam Singla. "Formulation, In-vitro and In-vivo Evaluation of Chronology-based Mucoadhesive Drug Delivery System of an Antihypertensive Drug." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 94–101. http://dx.doi.org/10.25258/ijddt.14.1.14.

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Current research aimed to prepare and estimate chronology-based mucoadhesive PDDS of antihypertensive drug losartan potassium through formulation of fast-dissolving core tablet and incorporation of core tablet to polymer coating to formulate bioadhesive PDDS through direct compression system. The coating was done by using polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was assessed for the formulation. The expected lag time for hypertension is 8 hours; hence, this lag time was achieved by using a bi

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james, Apollo, Jasmina khanam, Mohanraj Palanisamy, and Arun Radhakrishnan. "Preparation and Bio Pharmaceutical Evaluation of Chrono Pharmaceutical Drug Delivery System of Atenolol." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4761–69. http://dx.doi.org/10.55522/jmpas.v11i2.3310.

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A time-adjustable pulsatile release system containing atenolol as an active pharmaceutical agent was developed for bedtime dosage administration and release of medicine in the early morning to manage elevated blood pressure. The system contained an immediate release (IR) core, a sustained-release (SR) plug, and a mucoadhesive cup layer and it was designed by the cup and core technique. The immediate-release layer was composed of atenolol, croscarmellose sodium, microcrystalline cellulose (MCC), sorbitol, talc, and magnesium stearate. The SR plug was composed of hydroxyl propyl methylcellulose

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Gaidhankar, Smita L., Jaiprakash B. Ramanand, Parashram G. Kadam, Ajitkumar M. Zende, Rama R. Bhosale, and Nitin N. Puram. "A Study of drug utilization and clinical outcomes in indoor patients of hypertensive disorders of pregnancy." International Journal of Basic & Clinical Pharmacology 6, no. 10 (2017): 2401. http://dx.doi.org/10.18203/2319-2003.ijbcp20174367.

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Background: Hypertensive disorders of pregnancy are an important determinant of drug use during pregnancy. The aim of study was to assess the clinical outcome and evaluate drug utilization according to WHO core drug prescribing indicators in hypertensive disorders of pregnancy.Methods: This prospective, observational study in a tertiary care hospital was conducted in 150 pregnant women with hypertensive disorders of pregnancy from January 2014 and December 2014 who fulfilled the inclusion criteria. Antepartum and intrapartum care and the maternal and perinatal outcome were noted. The data was

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