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Journal articles on the topic 'Antihypertensive drug synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kumar, A. Sanjeev, Samir Ghosh, R. Soundararajan, and G. N. Mehta. "An improved synthesis of Telmisartan: an antihypertensive drug." Arkivoc 2009, no. 10 (2009): 247–54. http://dx.doi.org/10.3998/ark.5550190.0010.a22.

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2

Babu, Karrothu Srihari, Mallepalli Srinivasa Reddy, Amirisetty Ravindranath Tagore, et al. "Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug." Synthetic Communications 39, no. 2 (2008): 291–98. http://dx.doi.org/10.1080/00397910802372558.

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3

Kumar, A. Sanjeev, Samir Ghosh, G. N. Mehta, R. Soundararajan, P. S. R. Sarma, and Kale Bhima. "New and Improved Synthesis of Telmisartan: An Antihypertensive Drug." Synthetic Communications 39, no. 23 (2009): 4149–57. http://dx.doi.org/10.1080/00397910902840850.

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4

Senthilkumar, N., Y. S. Somannavar, Shankar B. Reddy, et al. "Synthesis of Active Metabolites of Carvedilol, an Antihypertensive Drug." Synthetic Communications 41, no. 2 (2010): 268–76. http://dx.doi.org/10.1080/00397910903534072.

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5

Belozertseva, E. G., B. A. Chakchir, O. V. Solod, and K. N. Zelenin. "Synthesis and antihypertensive activity of diaminomethylenehydrazonium iodides." Pharmaceutical Chemistry Journal 31, no. 6 (1997): 288–90. http://dx.doi.org/10.1007/bf02464116.

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6

Kumar, A. Sanjeev, Samir Ghosh, and G. N. Mehta. "A modification to the synthesis of Telmisartan: an antihypertensive drug." Journal of Chemical Research 34, no. 2 (2010): 95–97. http://dx.doi.org/10.3184/030823410x12656400473065.

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7

Loh, Yean Chun, Sock Ying Chan, Wan Yin Tew, Chuan Wei Oo, and Mun Fei Yam. "New flavonoid-based compound synthesis strategy for antihypertensive drug development." Life Sciences 249 (May 2020): 117512. http://dx.doi.org/10.1016/j.lfs.2020.117512.

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8

Patel, Ramesh N. "Enzymatic synthesis of chiral intermediates for Omapatrilat, an antihypertensive drug." Biomolecular Engineering 17, no. 6 (2001): 167–82. http://dx.doi.org/10.1016/s1389-0344(01)00068-5.

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9

Lefebvre, Jean, Luc Poirier, and Yves Lacourcière. "Methodology to Determine Duration of Action for Antihypertensive Drugs." Annals of Pharmacotherapy 36, no. 5 (2002): 874–81. http://dx.doi.org/10.1345/aph.10367.

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OBJECTIVE: To review and comment on methods used to assess the duration of action of antihypertensive drugs. DATA SOURCES: A MEDLINE search (1966–June 2000) using key terms such as trough-to-peak ratio and ambulatory blood pressure monitoring was conducted. STUDY SELECTION: An article was considered for this review if it pertained to the assessment of the duration of action of antihypertensive drugs. Special attention was given to articles dealing with methodologic aspects. DATA SYNTHESIS: Antihypertensive drugs with a long duration of action are thought to provide better therapeutic coverage

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10

Moutevelis-Minakakis, P., M. Gianni, H. Stougiannou, et al. "Design and synthesis of novel antihypertensive drugs." Bioorganic & Medicinal Chemistry Letters 13, no. 10 (2003): 1737–40. http://dx.doi.org/10.1016/s0960-894x(03)00251-8.

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11

Graevsksya, I. P., S. Yu Ryabova, L. M. Alekseeva, M. A. Kalinkina, M. É. Kaminka, and V. G. Granik. "Synthesis and antihypertensive activity of indolin-2-one dienediamines." Pharmaceutical Chemistry Journal 32, no. 11 (1998): 571–74. http://dx.doi.org/10.1007/bf02465824.

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12

Wang, Ping, Guo-jun Zheng, Ya-ping Wang, Xiang-jing Wang, He-geng Wei, and Wen-sheng Xiang. "Highly practical and cost-efficient synthesis of telmisartan: an antihypertensive drug." Tetrahedron 68, no. 11 (2012): 2509–12. http://dx.doi.org/10.1016/j.tet.2012.01.056.

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13

Rao, Somisetti Narender, Devarasetty Sitaramaiah, Kema Srimannarayana, Challa Nageswar Rao, Peddi Srinivasa Rao, and K. Sudhakar Babu. "Synthesis and Characterization of Potential Impurities of Carvedilol, an Antihypertensive Drug." Synthetic Communications 41, no. 1 (2010): 85–93. http://dx.doi.org/10.1080/00397910903531839.

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14

de Souza, Márcia C., Luan F. Diniz, Chris H. J. Franco, and Renata Diniz. "Synthesis and Crystalline Structure of Zinc Complexes with Antihypertensive Drug Lisinopril." Journal of Chemistry 2018 (October 18, 2018): 1–9. http://dx.doi.org/10.1155/2018/8910242.

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The structural investigation of Zn2+ complexes with the ligand lisinopril (LIS), an inhibitor of angiotensin-converting enzyme (ACE), was performed. The main objective is to compare if Zn-LIS coordination in vitro is similar to that observed in vivo. Two zinc complexes were obtained from different synthetic routes. The synthesis of LISZn1 used stirring, while for LISZn2 involved solvothermal conditions, which favoured the full deprotonation of lisinopril ligand. In this sense, the different synthetic routes resulted in the formation of complexes with notorious chemical and structural differenc

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15

Senthilkumar, N., Y. S. Somannavar, Shankar B. Reddy, et al. "ChemInform Abstract: Synthesis of Active Metabolites of Carvedilol, an Antihypertensive Drug." ChemInform 42, no. 28 (2011): no. http://dx.doi.org/10.1002/chin.201128208.

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16

Bao, Xiao-Lu, Wei-Bo Zhu, Tian-Li Shan, et al. "Design, synthesis and evaluation of novel angiotensin II receptor 1 antagonists with antihypertensive activities." RSC Advances 7, no. 42 (2017): 26401–10. http://dx.doi.org/10.1039/c7ra03915h.

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17

Moschona, Fotini, Ioanna Savvopoulou, Maria Tsitopoulou, Despoina Tataraki, and Gerasimos Rassias. "Epoxide Syntheses and Ring-Opening Reactions in Drug Development." Catalysts 10, no. 10 (2020): 1117. http://dx.doi.org/10.3390/catal10101117.

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This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to the substrate-controlled/diastereoselective and catalytic asymmetric synthesis of epoxide intermediates and their subsequent ring-opening reactions with various nucleophiles. These are described in the form of case studies of high profile pharmaceuticals spanning a diverse range of indications and molecular scaffolds such as heterocycles, terp

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18

Cairns, Donald, and Walter Sneader. "Synthesis of Novel Benzylimidazolines Possessing Antihypertensive and Sedative Activity." Archiv der Pharmazie 322, no. 7 (1989): 391–93. http://dx.doi.org/10.1002/ardp.19893220702.

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19

Venkanna, G., G. Madhusudhan, K. Mukkanti, A. Sankar, Y. Sampath Kumar, and G. Venakata Narayana. "Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/516459.

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Olmesartan medoxomil(1)is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl olmesartan (12), dimedoxomil olmesartan (19), dibiphenyl olmesartan (17). The present work describes the synthesis and characterization of all these three impurities.

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20

Ronchi, Fernanda A., Adriana B. Fernandes, Rosana I. Reis, et al. "Synthesis and Biological Evaluation of Novel Antihypertensive Compounds." Open Chemistry Journal 3, no. 1 (2016): 56–68. http://dx.doi.org/10.2174/1874842201603010056.

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Hypertension has been associated as a pathogenesis involved in the renin angiotensin system. The most commonly used drug to block the AT1R, is Losartan which has specific pharmacophore groups such as imidazole and biphenyl. However the development of new selective antagonists would be advantagous to improving the treatment of hypertension. We investigated innovative antihypertensive candidates1-3usingin vitroandin vivoassays.Although only Compound2showed low affinity to the AT1R, it had no effect on blood pressure. Compound1produced a reduction in blood pressure and this effect seems to be med

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21

Granik, V. G., S. I. Grizik, I. F. Fayermark, et al. "Synthesis and antihypertensive activity of several N-acyl D-penicillamines." Pharmaceutical Chemistry Journal 23, no. 11 (1989): 890–93. http://dx.doi.org/10.1007/bf00764613.

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22

Belozertseva, E. G., B. A. Chakchir, O. V. Solod, and K. N. Zelenin. "Synthesis and antihypertensive activity of 1-alkylidene(arylidene)benzamidrazone salts." Pharmaceutical Chemistry Journal 31, no. 8 (1997): 406–8. http://dx.doi.org/10.1007/bf02464351.

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23

Velázquez, A. Ma, L. Martínez, V. Abrego, et al. "Synthesis and antihypertensive effects of new methylthiomorpholinphenol derivatives." European Journal of Medicinal Chemistry 43, no. 3 (2008): 486–500. http://dx.doi.org/10.1016/j.ejmech.2007.04.003.

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24

Cheng, Zhi-Gang, Xu-Yong Dai, Li-Wei Li, Qiong Wan, Xiang Ma, and Guang-Ya Xiang. "Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance." Molecules 19, no. 1 (2014): 1344–52. http://dx.doi.org/10.3390/molecules19011344.

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25

Raju, V. V. N. K. V. Prasada, Ganta Madhusudhan Reddy, Vedantham Ravindra, Vijayavitthal T. Mathad, P. K. Dubey, and Padi Pratap Reddy. "Synthesis and Spectral Characterization of Related Substances of Lacidipine, an Antihypertensive Drug." Synthetic Communications 39, no. 12 (2009): 2137–45. http://dx.doi.org/10.1080/00397910802638560.

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26

Kumar, A. Sanjeev, Samir Ghosh, and G. N. Mehta. "ChemInform Abstract: A Modification to the Synthesis of Telmisartan: An Antihypertensive Drug." ChemInform 41, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.201031134.

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27

Vio, Luciano, Maria Grazia Mamolo, and Giorgio Pellizer. "Synthesis and Antihypertensive Activity of Some Aminoguanidine and Amidrazone Derivatives." Archiv der Pharmazie 321, no. 10 (1988): 713–17. http://dx.doi.org/10.1002/ardp.19883211002.

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28

Nikalje, Anna P. G., Mangesh S. Ghodke, Firoz A. K. Khan, and Jaiprakash N. Sangshetti. "Microwave Assisted Facile Synthesis and Biological Evaluation of Novel 2-Indolyl -1, 5-Benzothiazepines." Open Pharmaceutical Sciences Journal 3, no. 1 (2016): 117–30. http://dx.doi.org/10.2174/1874844901603010117.

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Background: The research work reports facile, eco-friendly microwave- assisted solvent free synthesis of coupled heterocyclic system 2-(1H-indol-3-yl)-4-substitued-2, 3-dihydrobenzo [1, 5] thiazepine derivatives obtained by cyclo condensation of 1-substituted-3(1H-indolyl)-2-propen-1-ones with 2-amino thiophenol in presence of eco-friendly catalyst zirconium(IV) oxy chloride, in solvent-free conditions. The reaction was completed in 3-6 minutes and gives better yields than the conventional synthesis which requires 6-8 hrs. Result and Conclusion: The newly synthesized compounds were evaluated f

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29

Ashwood, Valerie A., Robin E. Buckingham, Frederick Cassidy, et al. "Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans." Journal of Medicinal Chemistry 29, no. 11 (1986): 2194–201. http://dx.doi.org/10.1021/jm00161a011.

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30

Ashwood, Valerie A., Frederick Cassidy, Martin C. Coldwell, et al. "Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans." Journal of Medicinal Chemistry 33, no. 9 (1990): 2667–72. http://dx.doi.org/10.1021/jm00171a051.

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31

Corsano, Stefano, Giovannella Strappaghetti, and Antonella Codagnone. "Synthesis and Antihypertensive Properties of Benzodioxane-pyridazinones and Benzodioxane-dihydropyridazinones Synthese und antihypertensive Eigenschaften von Benzodioxan-pyridazinonen und Benzodioxan-dihydropyridazinonen." Archiv der Pharmazie 322, no. 11 (1989): 833–35. http://dx.doi.org/10.1002/ardp.19893221113.

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32

Mastafanova, L. I., I. P. Isakovich, G. Ya Shvarts, et al. "Synthesis and antihypertensive activity of N-acetylmercaptopropionyl-6-(2?-phenylethyl)pipecolinic acids." Pharmaceutical Chemistry Journal 22, no. 3 (1988): 212–20. http://dx.doi.org/10.1007/bf00758271.

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33

Noskov, V. G., S. V. Shishkov, Yu L. Kruglyak, et al. "Synthesis and antihypertensive activity of some 1-o-alkylglycero-3-phosphocholine derivatives." Pharmaceutical Chemistry Journal 30, no. 10 (1996): 607–10. http://dx.doi.org/10.1007/bf02333883.

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34

Devi, Runjun, and Sajal Kumar Das. "Studies directed toward the exploitation of vicinal diols in the synthesis of (+)-nebivolol intermediates." Beilstein Journal of Organic Chemistry 13 (March 21, 2017): 571–78. http://dx.doi.org/10.3762/bjoc.13.56.

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While the exploitation of the Sharpless asymmetric dihydroxylation as the source of chirality in the synthesis of acyclic molecules and saturated heterocycles has been tremendous, its synthetic utility toward chiral benzo-annulated heterocycles is relatively limited. Thus, in the search for wider applications of Sharpless asymmetric dihydroxylation-derived diols for the synthesis of benzo-annulated heterocycles, we report herein our studies in the asymmetric synthesis of (R)-1-((R)-6-fluorochroman-2-yl)ethane-1,2-diol, (R)-1-((S)-6-fluorochroman-2-yl)ethane-1,2-diol and (S)-6-fluoro-2-((R)-oxi

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35

Corsano, Stefano, Giovannella Strappaghetti, Rossana Scapicchi, and Vittorio Anania. "Synthesis and Antihypertensive Properties of Some Dopamino-pyridazin-3(2H)-one Derivatives." Archiv der Pharmazie 325, no. 3 (1992): 187–91. http://dx.doi.org/10.1002/ardp.19923250309.

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36

Cassidy, Frederick, John M. Evans, Michael S. Hadley, Adele H. Haladij, Patricia E. Leach, and Geoffrey Stemp. "Synthesis and antihypertensive activity of 3-[(substituted-carbonyl)amino]-2H-1-benzopyrans." Journal of Medicinal Chemistry 35, no. 9 (1992): 1623–27. http://dx.doi.org/10.1021/jm00087a018.

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37

Dams, Iwona, Agata Białońska, Piotr Cmoch, et al. "Synthesis and Physicochemical Characterization of the Process-Related Impurities of Eplerenone, an Antihypertensive Drug." Molecules 22, no. 8 (2017): 1354. http://dx.doi.org/10.3390/molecules22081354.

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38

Hirawa, Nobuhito, Yoshio Uehara, Atsushi Numabe, et al. "Stimulating effects of atenolol on vasodepressor prostaglandin generation in spontaneously hypertensive rats." Clinical Science 81, s25 (1991): 499–507. http://dx.doi.org/10.1042/cs0810499.

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1. To assess the role of the vasodepressor prostaglandin system in the antihypertensive properties of β-adrenoceptor antagonist, we investigated the alterations of prostaglandin generation in the kidney and in the aorta when spontaneously hypertensive rats were treated with atenolol for 2 weeks. 2. The blood pressure reduction was associated with an increase in urinary sodium excretion and urinary prostaglandin E2 excretion. The sodium excretion was positively related to the prostaglandin E2 excretion. 3. Basal release of prostaglandin E2 from the sliced renal cortex was enhanced by the atenol

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39

Neill, Colin G., Peter N. Preston, and Richard H. Wightman. "Synthesis of pyrido-1,2,4-thiadiazines related to antihypertensive 1,2,4-benzothiadiazine-1,1-dioxides." Tetrahedron 54, no. 44 (1998): 13645–54. http://dx.doi.org/10.1016/s0040-4020(98)00841-2.

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40

Minushkina, L. O. "Hypertension treatment: Is there a place for b-adrenoblockers?" Systemic Hypertension 10, no. 1 (2013): 48–51. http://dx.doi.org/10.26442/sg28945.

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The paper considers whether b-adrenoblockers may be used in the therapy of hypertension. It views in more detail the specific features of nebivolol, a third-generation highly selective b-adrenoblocker that has properties of acting on endothelial function and stimulating NO synthesis. The possible mechanism for the angioprotective activity of the drug is described. There is evidence for its antihypertensive efficacy. The effect of nebivolol on target organs in hypertension, its metabolic effects, and the possibilities of using the drug in patients with comorbidities are considered.

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41

Bagheri, Maryam, Maryam Shekarchi, Masoumeh Jorjani, Mohammad Hossein Ghahremani, Mohssen Vosooghi, and Abbas Shafiee. "Synthesis and Antihypertensive Activity of 1-(2-Thiazolyl)-3, 5-disubstituted -2-Pyrazolines." Archiv der Pharmazie 337, no. 1 (2004): 25–34. http://dx.doi.org/10.1002/ardp.200300810.

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42

Manoury, Philippe M., Jean L. Binet, Andre P. Dumas, Francoise Lefevre-Borg, and Icilio Cavero. "Synthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives." Journal of Medicinal Chemistry 29, no. 1 (1986): 19–25. http://dx.doi.org/10.1021/jm00151a003.

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43

Asselin, Andre A., Leslie G. Humber, Danilo Crosilla, et al. "Indole-phenol-bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analog of labetalol." Journal of Medicinal Chemistry 29, no. 6 (1986): 1009–15. http://dx.doi.org/10.1021/jm00156a019.

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44

Granik, V. G., L. A. Yakusheva, S. I. Grizik, et al. "Synthesis and antihypertensive action of n-?-acetyl hydrazide of 1-(??-mercaptopropionyl)-6-methylpipecolic acid." Pharmaceutical Chemistry Journal 23, no. 8 (1989): 635–40. http://dx.doi.org/10.1007/bf00766377.

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45

Ham, Won-Hun, Chang-Young Oh, Tae-Gyun Lim, Yun-Ho Jung, and Young-Hoon Jung. "Synthesis of pyrido [4,3-f]-1,5-thiazepine as a potential antihypertensive agent." Archives of Pharmacal Research 18, no. 5 (1995): 366–68. http://dx.doi.org/10.1007/bf02976335.

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46

Wu, E. S. C., T. E. Cole, T. A. Davidson, et al. "Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without .beta.-adrenoceptor antagonism." Journal of Medicinal Chemistry 30, no. 5 (1987): 788–92. http://dx.doi.org/10.1021/jm00388a007.

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47

MUHANA, F., R. ABU-HUWAIJ, N. KHALAF, F. KHALILI, and N. SHALAN. "Synthesis and Characterization of Mesoporous Silica Carrier Releasing Valsartan." Asian Journal of Chemistry 32, no. 11 (2020): 2927–33. http://dx.doi.org/10.14233/ajchem.2020.22901.

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The aim of the present study is to synthesize a mesoporous silica MCM-48 and loading it with the poorly soluble drug valsartan. The MCM-48 was characterized by Brauner-Emmett-Teller surface area analyzer, scanning electron microscope, powder X-ray diffraction, thermal gravimetric analysis and Fourier transform infra-red (FTIR). The exact loading capacity was found to be 40.12%. in vitro dissolution studies at physiological conditions demonstrated controlled release of 57.2% valsartan over 240 min. The controlled dissolution was attributed to the incomplete amorphization of crystalline valsarta

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48

Ham, Won-Hun, Jae-Gwon Yang, Tae-Gyun Lim, Yun-Ho Jung, and Yun-Sung Chung. "Synthesis of antihypertensive agents via coupling reaction of Benzothiazepinone and 1,4-dihydropyridine derivatives." Archives of Pharmacal Research 17, no. 2 (1994): 119–23. http://dx.doi.org/10.1007/bf02974235.

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49

Schein, Jeffrey R. "Cigarette Smoking and Clinically Significant Drug Interactions." Annals of Pharmacotherapy 29, no. 11 (1995): 1139–48. http://dx.doi.org/10.1177/106002809502901113.

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Objective: To review clinically significant drug interactions associated with cigarette smoking. Data Sources: Data from scientific literature were identified by using a MEDLINE search. Data were extracted, evaluated, and summarized for this review. Study Selection: Findings and experiences were selected from clinical, epidemiologic, and pharmacokinetic studies; review articles; case studies; abstracts; letters to the editor; and proceedings. Data Extraction: Data from human studies published in English were evaluated. Only interactions deemed clinically significant are included in this review

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50

Turner, Stephen, Malcolm Myers, Brian Gadie, et al. "Antihypertensive thiadiazoles. 1. Synthesis of some 2-aryl-5-hydrazino-1,3,4-thiadiazoles with vasodilator activity." Journal of Medicinal Chemistry 31, no. 5 (1988): 902–6. http://dx.doi.org/10.1021/jm00400a003.

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