Academic literature on the topic 'Antimalarial drug efficacy'

Malaria is a global health problem that needs attention from drug discovery scientists to investigate novel compounds with high drug efficacy, safety and low cost to encounter the malaria parasites that are resistant to existing drug molecules. Antimalarial drug development follows several approaches, ranging from modifications of existing agents to the design of novel agents that act against novel targets. Most of market and clinical drugs act on blood schizonticide are in current therapy for malaria reduction. This chapter will intend to highlight the currently available drugs including various novel agents. In addition, emphasis has been given on the prospective pharmacophores that are likely to emerge as effective clinical candidates in the treatment of malaria. Besides all aspects, some alternative approaches will also be highlight.

Nanotechnology has vast applications in virtually all the fields including health and environment. Nanomaterials have different origins like plants, animals, metals, and microorganisms. They have larvicidal activities against mosquito larvae that cause malaria and dengue fever which are most malicious parasitic diseases of human beings. Multidrug resistance of malaria has been reported in different parts of Southeast Asia especially to the first line of antimalarial drugs. Nanomaterials having different origin, sizes, concentrations, and shapes, have varied efficacy against the vectors which are comparable with the commercially available insecticides and even have better results than the same. Nanomaterials can be used as an alternative to commercially available insecticides for the eradication of vectors causing both the diseases. In this chapter, types, sources, composition, larvicidal potential against vectors of nanomaterials have been discussed along with possible toxicity and future recommendations on the eco-friendly approach for the control of mosquito-borne diseases.