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Dissertations / Theses on the topic 'Antimalarial plants'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Chen, Dianne Tzu-Hsiu. "Phytochemical studies on traditional medicinal plants with antimalarial activities." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/21853.

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The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51

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2

Uche, Fidelia Ijeoma. "Phytochemical analysis and evaluation of anticancer and antimalarial properties of four medicinal plants." Thesis, Keele University, 2017. http://eprints.keele.ac.uk/3080/.

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Cancer and malaria are among the most life-threatening diseases globally. Cancer is responsible for about 125,000 annual deaths globally. In 2015, the World Health Organization report estimated that 236000-635000 people died of malaria. These diseases are complicated by the development of resistance to available chemotherapeutic agents. Natural products have been recognized for their major applications in the identification of drug leads in drug discovery. Viola philippica Car, Viola yedoensis Makino (Violaceae), Triclisia subcordata Oliv (Menispermeaceae) and Cyclicodiscus gabunensis Harms (F

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3

Wright, Colin W. "Recent developments in research on terrestrial plants used for the treatment of malaria." Royal Society of Chemistry, 2010. http://hdl.handle.net/10454/4541.

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no<br>New antimalarial drugs are urgently needed to combat emerging multidrug resistant strains of malaria parasites. This Highlight focuses on plant-derived natural products that are of interest as potential leads towards new antimalarial drugs including synthetic analogues of natural compounds, with the exception of artemisinin derivatives, which are not included due to limited space. Since effective antimalarial treatment is often unavailable or unaffordable to many of those who need it, there is increasing interest in the development of locally produced herbal medicines; recent progre

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4

Sekhoacha, Mamello. "Antimalarial activity and cytotoxicity of some South African medicinal plants and their active constituents." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3300.

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5

Eaton, Alexander Lee. "Isolation and Synthesis of Bioactive Compounds from Plants." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64367.

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As a part of a continuing search for bioactive compounds with the International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), twelve plant extracts were investigated for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y inhibition). Bioassay-guided fractionation of extracts led t

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6

Waako, Paul. "The antimalarial potential of Ugandan traditional medicines : a study of six plants used to treat malaria symptoms." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/8602.

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Bibliography: leaves 102-122.<br>The study investigates the antimalarial potential of six Ugandan traditional medicinal plants Senecfo discifolius oliv, Senecio stuhlmannii, Indigofera emarginella steud. Ex A. Rich, Aspifia africana (Pers) C.D. Adams, Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. Selection of the plants was based on ethnobotanical surveys of traditional treatment of malaria symptoms and reports from traditional healers practising in three different communities.

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7

Machado, Freitas de Souza Luciane. "Malaria Entangled: Ribeirinhos, Plants, Mosquitoes, and Public Health Interventions in the Brazilian Amazon." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36156.

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This ethnographic study was conducted among the riverine people, also known as Ribeirinhos, in the state of Amazonas, Brazil, during four months of field research. The study focused on learning from Ribeirinhos’ experiences and practices of malaria. In this thesis, I argue that paying attention to Ribeirinhos’ experiences and diagnostic, treatment, and control practices of malaria can provide useful insights into blind spots in the current interventions to control the disease in Brazil. As this is a thesis by publications, the findings are presented in three manuscripts. The first manuscript f

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8

Okpako, Larry Commander. "Investigation of selected Nigerian medicinal plants as a source of new antimalarial agents. Isolation of phytochemicals from some Nigerian medicinal plants using chromatographic techniques and their evaluation for antiplasmodial activity." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/6304.

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Malaria affects hundreds of millions of people worldwide and equally claims hundreds of thousands of lives each year. With the current spread of drug resistance to standard antimalarial drugs like chloroquine and the emergence of artemisinin-resistant parasites, new antimalarial drugs and formulations are urgently needed. An ethnobotanical survey was carried out in this study in search of novel compounds with promising antiplasmodial activity. Using the ethnobotanical approach, a total of 61 plant species from 59 genera distributed in 34 plant families were found to be used traditionally for

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9

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Thesis, Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315/.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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10

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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11

Wallaart, Thorvald Eelco. "Investigations on the biosynthesis of the novel antimalarial drug artemisinin in the plant Artemisia annua /." Groningen, 2000. http://www.gbv.de/dms/bs/toc/318078724.pdf.

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12

Afoulous, Samia. "Valorisation des plantes médicinales d’origines africaines, évaluation et identification des molécules à activités biologiques (antioxydante, anticancéreuse et antimalariale, …)." Toulouse 3, 2013. http://www.theses.fr/2013TOU30325.

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Cette thèse, avec financement CIFRE, a été réalisée au sein du laboratoire des IMRCP (UMR 5623) de l’Université Paul Sabatier (Université de Toulouse) en collaboration avec la Société Nat’Ex Biotech. Les travaux de cette thèse ont été focalisés sur l’étude phytochimique et criblage biologique de métabolites secondaires pour la recherche de nouvelle(s) molécule(s) bioactive(s). Dans ce cadre, deux plantes médicinales de la flore malgache ont été ciblées, Helichrysum gymnocephalum (Astéracées) et Cedrelopsis grevei (Ptaeroxylacées). En premier lieu, l’étude a porté sur l’identification des compo

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13

Mello, Graziela da Silva. "Avaliação do potencial antimalárico de Norantea brasiliensis Choisy (Marcgraviaceae) cultivada in vitro e in vivo." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8936.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>A malária é uma doença infecciosa causada por protozoários do gênero Plasmodium, transmitidos ao homem, principalmente, através da picada do mosquito infectado. O tratamento é realizado por meio do uso de drogas, como a cloroquina, uma vez que não há vacina eficiente contra a doença. Porém, a resistência dos parasitos aos medicamentos tem levado à busca por novas substâncias com atividade antimalárica, inclusive de origem vegetal. Nesse contexto, o presente trabalho teve por objetivo avaliar a atividade antimalárica de extratos m

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14

Tomchinsky, Bernardo [UNESP]. "Etnobotânica de plantas antimaláricas em Barcelos, Amazonas." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/93547.

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Made available in DSpace on 2014-06-11T19:26:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-31Bitstream added on 2014-06-13T18:54:59Z : No. of bitstreams: 1 000753711.pdf: 3825617 bytes, checksum: d602dc7d0b7403a01a3c8c28de208a0f (MD5)<br>A malária persiste como uma das principais doenças negligenciadas em todo o mundo. Anualmente três milhões de pessoas a contraem e cerca de um milhão morrem por causa dela. A região do mundo mais afetada é a África Subsariana e, no Brasil, a região amazônica é a mais afetada. As populações locais aprenderam a retirar do meio ambiente os recurs

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15

Tomchinsky, Bernardo 1987. "Etnobotânica de plantas antimaláricas em Barcelos, Amazonas /." Botucatu :, 2014. http://hdl.handle.net/11449/93547.

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Orientador: Lin Chau Ming<br>Banca: Ari de Freitas Hidalgo<br>Banca: Maria Christina de Mello Amorozo<br>Resumo: A malária persiste como uma das principais doenças negligenciadas em todo o mundo. Anualmente três milhões de pessoas a contraem e cerca de um milhão morrem por causa dela. A região do mundo mais afetada é a África Subsariana e, no Brasil, a região amazônica é a mais afetada. As populações locais aprenderam a retirar do meio ambiente os recursos necessários para sobreviver e são atualmente a principal esperança na descoberta de novos medicamentos antimaláricos frente ao parasita da

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16

Ilboudo, P. D. "IN VITRO THERAPEUTIC VALUE OF PLANT EXTRACTS USED IN BURKINA FASO TO TREAT MALARIA AND IN VITRO PHARMACODYNAMIC STUDIES OF ANTIMALARIAL DRUGS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171918.

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My PhD project has developed in two main research areas, both related to antimalarial drug discovery. The first part was focused on the study of the antimalarial and anti-inflammatory activity of medicinal plants used in Burkina Faso to treat malaria; the second part was dedicated to the development of new tools to measure in vitro the pharmacodynamic characteristics of current or new drugs to predict early on their clinical behavior. The work was conducted in the Laboratory of Parasitology, Department of Public Health- Microbiology -Virology of the University of Milan and at the Liverpool Sch

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17

Wanderley, Bruno Mattos Silva. "Atividade antiplasm?dica e toxicol?gica de plantas medicinais usadas popularmente no Brasil : uma abordagem etnobot?nica." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13090.

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Made available in DSpace on 2014-12-17T14:10:27Z (GMT). No. of bitstreams: 1 BrunoMSW_DISSERT.pdf: 2493064 bytes, checksum: 67d2a8f0addf9c48ec5976ed766a8e15 (MD5) Previous issue date: 2012-10-15<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Malaria is a disease of global distribution, recognized by governments around the world as a serious public health problem, affecting more than 109 countries and territories and endangering more than 3.3 billion people. The economic costs of this disease are also relevant: the African continent itself has malaria-related costs of about

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18

Mahadeo, Keshika. "Étude métabolomique et valorisation pharmacologique et biotechnologique d'éspèces du genre Psiadia endémiques de la Réunion et de l'ile Maurice." Thesis, La Réunion, 2018. http://www.theses.fr/2018LARE0001/document.

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Les travaux de thèse présentés dans ce manuscrit portent sur l’étude chimique de plantes du genre Psiadia. Trois axes de recherche ont été menés parallèlement à savoir (1) une étude chimiotaxonomique à partir de 11 espèces du genre Psiadia endémiques de La Réunion, (2) un criblage biologique réalisé sur 16 espèces du genre Psiadia dont 11 endémiques de La Réunion et 5 endémiques de Maurice et (3) une étude phytochimique ciblée sur l’espèce Psiadia arguta endémique de Maurice. Le premier axe comportant l'étude chimiotaxonomique menée par une approche métabolomique avait pour objectif d'identifi

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19

Ibanez, Calero Sandra. "Application du test d'inhibition de la biocristallisation de l'hème à la caractérisation de composés antipaludiques isolés de la flore de Bolivie." Toulouse 3, 2005. http://www.theses.fr/2005TOU30090.

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La vallée du Zongo, située au nord de la ville de La Paz en Bolivie, est une vallée tropicale transandine d'altitude présentant une importante diversité végétale. Dans le cadre d'une recherche de nouveaux composés antipaludiques, cinquante huit plantes caractéristiques de la flore de cet endroit ont été soumises à l'essai d'inhibition de biocristallisation de la ferriprotoporphyrine IX (FBIT) pour évaluer leur capacité à empêcher la formation d'hémozoïne plasmodiale. De 134 extraits testés, 14 espèces se sont montrées actives. L'essai in vitro sur la schizogonie erythrocytaire de Plasmodium fa

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20

Adebayo, Oluwakemi Monisola. "Isolation, characterisation and antimalarial activity of four selected South African plants." Diss., 2019. http://hdl.handle.net/11602/1444.

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MSc (Chemistry)<br>Department of Chemistry<br>Malaria, an infectious disease affecting both human beings and other animals, is transmitted by parasitic protozoans belonging to the Plasmodium genus. Malaria is commonly treated with drugs such as quinine, chloroquine, and artesunate. However, the incidence of treatment failure due to drug-drug interactions and parasite resistance is increasing. Therefore, the rich medicinal potential of plants found in nature in Africa is increasingly being explored. The traditional use of Lippia javanica, Sclerocarya birrea, Melia azedarach and Capparis toment

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21

Prozesky, Erwin Antoni. "In vitro antimalarial activity of ethnobotanically selected indigenous plants and characterisation of a bioactive compound." Diss., 1999. http://hdl.handle.net/2263/29226.

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Malaria still remains one of the world’s biggest killers with more than two million people dying from the disease each year. Present drugs have become ineffective because parasites are developing resistance to most of them. Efforts are now being directed in obtaining drugs with different structural features. Plants have provided most of the antimalarial drugs so far and efforts now concentrate on screening plants for new antimalarial drugs. South Africa with its rich floral resources and ethnobotanical history is an ideal place to screen plants for antimalarial activity. The antimalarial activ

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22

Bilonda, Kabuyi Mireille. "Computational study of antimalarial alkaloids of plant origin." Thesis, 2018. http://hdl.handle.net/11602/1282.

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Department of Chemistry<br>PhD (Chemistry)<br>This thesis is concerned with the computational study of naphthylisoquinoline alkaloids having antimalarial properties. The study was considered interesting because of the importance of gathering information on antimalarial molecules and because these molecules had not yet been studied computationally. The alkaloids considered in this study had been isolated from tropical lianas belonging to the Dioncophyllaceae and Ancistrodaceae families. They comprise alkaloids with both monomeric and dimeric structures. The monomeric structures consist of one

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23

Wallaart, Eelco. "Investigations on the biosynthesis of the novel antimalarial drug artemisinin in the plant Artemisia annua /." 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009659813&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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24

Ramalhete, Cátia Beatriz Almeida 1980. "Search for bioactive compounds from medicinal plants used as antimalarials : the study of Momordica balsamina L." Doctoral thesis, 2010. http://hdl.handle.net/10451/2278.

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Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculdade de Farmácia, 2010<br>The main goal of this dissertation was to search for new antimalarial compounds from plants used in traditional medicine. For the purpose, the claimed antimalarial properties of fifty eight extracts from fifteen plants, used in traditional medicine against malaria and/or fever, mainly in Mozambique, were evaluated against the 3D7 Plasmodium falciparum strain. The highest activity was shown by Momordica balsamina L. (Cucurbitaceae), which was selected for further studi

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25

Douwes, Errol. "Bioprospecting the flora of southern Africa : optimising plant selections." Thesis, 2005. http://hdl.handle.net/10413/5529.

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Focused procedures which streamline and optimise plant prioritisation and selection in bioprospecting have the potential to save both time and resources. A variety of semiquantitative techniques were assessed for their ability to prioritise ethnomedicinal taxa in the Flora of Southern Africa (FSA) region. These techniques were subsequently expanded upon for application in plant selection for the Novel Drug Development Platform bioprospecting programme. Least squares regression analyses were used to test the hypothesis that ethnomedicinal plant use in southern Africa is strictly random, i.e. no

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26

Chukwujekwu, Jude Chinedu. "A pharmacological study of some Nigerian medicinal plants." Thesis, 2005. http://hdl.handle.net/10413/10196.

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Petroleum ether, dichloromethane, and 80% ethanol extracts of 15 plant species collected in Nigeria were screened for in vitro antibacterial, anti-inflammatory and antimalarial activities. Antibacterial activity was tested using the agar diffusion method, while the minimum inhibitory concentrations (MIC) of the active extracts were determined using the microtitre serial dilution method. Most antibacterial activity detected was against Gram-positive bacteria with Staphylococcus aureus being the most susceptible. The highest activity was found in petroleum ether and dichloromethane leaf extracts

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