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Journal articles on the topic 'Antimalarials – Therapeutic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Duncan, MR, and HA Capell. "The use of antimalarials in combination with other disease modifying agents in RA – the British experience." Lupus 5, no. 1_suppl (1996): 50–58. http://dx.doi.org/10.1177/0961203396005001121.

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Antimalarial drugs are effective disease modifying agents in RA with a low incidence of serious toxic effects. Recently, combinations of second-line agents have been used in RA in attempts to treat patients with no response to a number of single agents, or suboptimal response to a single agent. Combinations of drugs have been selected for maximum efficacy and minimum toxicity, but clinical trials are difficult to design and interpret. In particular, ensuring adequate power to detect small differences in response poses a major problem. Antimalarials are an attractive choice for combination ther

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2

Tang, Yu-Qing, Qian Ye, He Huang, and Wei-Yi Zheng. "An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance." Current Molecular Medicine 20, no. 8 (2020): 583–92. http://dx.doi.org/10.2174/1566524020666200207123253.

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: Malaria is one of the three most deadly infectious diseases in the world and seriously endangers human health and life. To reduce the public health burden of this disease, scientists have focused on the discovery and development of effective antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its derivatives, which all play a profound role in the treatment of malaria. However, drugresistant strains of Plasmodium falciparum have emerged due to frequent use of antimalarials and have become increasingly resistant to existing antimalarial drugs, causing disastrous

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3

Ambroise-Thomas, Pierre. "THE TRAGEDY CAUSED BY FAKE ANTIMALARIAL DRUGS." Mediterranean Journal of Hematology and Infectious Diseases 4, no. 1 (2012): e2012027. http://dx.doi.org/10.4084/mjhid.2012.027.

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Counterfeit antimalarials (mainly artemisinin derivatives) is a crucial health problem in developing countries, particularly in Africa. The illegal production, sale and distribution of fake drugs is a huge market evaluated to several billion of dollars and represents more than 50% of the pharmaceutical market in several African countries. Fake drugs have led to a very great number of deaths from untreated malaria or fatality provoked by toxic ingredients. These fake medicines increase the risk of artemisinin resistance developed by the use of sub therapeutic dosages of antimalarials. Tackling

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Piedade, Rita, Stefanie Traub, Andreas Bitter, et al. "Carboxymefloquine, the Major Metabolite of the Antimalarial Drug Mefloquine, Induces Drug-Metabolizing Enzyme and Transporter Expression by Activation of Pregnane X Receptor." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 96–104. http://dx.doi.org/10.1128/aac.04140-14.

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ABSTRACTMalaria patients are frequently coinfected with HIV and mycobacteria causing tuberculosis, which increases the use of coadministered drugs and thereby enhances the risk of pharmacokinetic drug-drug interactions. Activation of the pregnane X receptor (PXR) by xenobiotics, which include many drugs, induces drug metabolism and transport, thereby resulting in possible attenuation or loss of the therapeutic responses to the drugs being coadministered. While several artemisinin-type antimalarial drugs have been shown to activate PXR, data on nonartemisinin-type antimalarials are still missin

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Stevens, David M., Rachael M. Crist, and Stephan T. Stern. "Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine." Molecules 26, no. 1 (2020): 175. http://dx.doi.org/10.3390/molecules26010175.

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The chloroquine family of antimalarials has a long history of use, spanning many decades. Despite this extensive clinical experience, novel applications, including use in autoimmune disorders, infectious disease, and cancer, have only recently been identified. While short term use of chloroquine or hydroxychloroquine is safe at traditional therapeutic doses in patients without predisposing conditions, administration of higher doses and for longer durations are associated with toxicity, including retinotoxicity. Additional liabilities of these medications include pharmacokinetic profiles that r

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6

Burns, Amy L., Madeline G. Dans, Juan M. Balbin, et al. "Targeting malaria parasite invasion of red blood cells as an antimalarial strategy." FEMS Microbiology Reviews 43, no. 3 (2019): 223–38. http://dx.doi.org/10.1093/femsre/fuz005.

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AbstractPlasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle rel

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7

Kuhn, A., F. Ochsendorf, and G. Bonsmann. "Treatment of cutaneous lupus erythematosus." Lupus 19, no. 9 (2010): 1125–36. http://dx.doi.org/10.1177/0961203310370345.

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In patients with cutaneous lupus erythematosus (CLE) and mild skin involvement, local therapy consisting of topically applied pharmacological agents, e.g., topical/intralesional steroids, may be sufficient. Recent reports have also shown efficacy of topical calcineurin inhibitors in patients with CLE, particularly on the face. Special attention receives consistent sun protection through photoresistant clothing and application of light-shielding substances with highly potent chemical or physical UVA- and UVB-protective filters. These substances should be applied in sufficient amount (ca. 2 mg/c

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Kwofie, Samuel K., Emmanuel Broni, Bismark Dankwa, et al. "Review of Atypical Organometallic Compounds as Antimalarial Drugs." Journal of Chemistry 2020 (May 20, 2020): 1–9. http://dx.doi.org/10.1155/2020/9414093.

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Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in compa

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Ruwizhi, Ngonidzashe, and Blessing Atim Aderibigbe. "The Efficacy of Cholesterol-Based Carriers in Drug Delivery." Molecules 25, no. 18 (2020): 4330. http://dx.doi.org/10.3390/molecules25184330.

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Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers

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10

Alsharif, Sahar H., Reda H. Saifaldeen, and Logain G. Alghanemi. "Successful treatment of granuloma faciale." International Journal of Research in Dermatology 7, no. 1 (2020): 129. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20205609.

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<p class="abstract">Granuloma faciale (GF) is a chronic condition characterized by asymptomatic erythematous plaque with prominent telangiectasia presenting usually over the face. Although the condition is benign, its treatment is often unsatisfactory. Therapeutic modalities that have been tried include topical steroids and topical tacrolimus sometimes enhanced with topical dapsone. Others include intralesional corticosteroids, antimalarials, isoniazid and pulsed-dye laser. We report a case of a 58 years old female with a 1 year history of a solitary slowly progressive plaque over the no

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Kaddouri, Halima, Serge Nakache, Sandrine Houzé, France Mentré, and Jacques Le Bras. "Assessment of the Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa by Using a Plasmodium Lactate Dehydrogenase Immunodetection Assay and an Inhibitory Maximum Effect Model for Precise Measurement of the 50-Percent Inhibitory Concentration." Antimicrobial Agents and Chemotherapy 50, no. 10 (2006): 3343–49. http://dx.doi.org/10.1128/aac.00367-06.

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ABSTRACT The extension of drug resistance among malaria-causing Plasmodium falciparum parasites in Africa necessitates implementation of new combined therapeutic strategies. Drug susceptibility phenotyping requires precise measurements. Until recently, schizont maturation and isotopic in vitro assays were the only methods available, but their use was limited by technical constraints. This explains the revived interest in the development of replacement methods, such as the Plasmodium lactate dehydrogenase (pLDH) immunodetection assay. We evaluated a commercially controlled pLDH enzyme-linked im

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Ferreira, Paulo Michel Pinheiro, José Roberto de Oliveira Ferreira, Rayran Walter Ramos de Sousa, Daniel Pereira Bezerra, and Gardenia Carmen Gadelha Militão. "Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features." Journal of Oncology 2021 (September 3, 2021): 1–18. http://dx.doi.org/10.1155/2021/3569349.

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The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. This well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies also occur. These molecules are lysosomotropic amines th

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Atzeni, Fabiola, Ignazio Francesco Masala, Javier Rodríguez-Carrio, et al. "The Rheumatology Drugs for COVID-19 Management: Which and When?" Journal of Clinical Medicine 10, no. 4 (2021): 783. http://dx.doi.org/10.3390/jcm10040783.

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Introduction: While waiting for the development of specific antiviral therapies and vaccines to effectively neutralize the SARS-CoV2, a relevant therapeutic strategy is to counteract the hyperinflammatory status, characterized by an increase mainly of interleukin (IL)-1β, IL-2, IL-6, IL-7, IL-8, and tumor necrosis factor (TNF)-α, which hallmarks the most severe clinical cases. ‘Repurposing’ immunomodulatory drugs and applying clinical management approved for rheumatic diseases represents a game-changer option. In this article, we will review the drugs that have indication in patients with COVI

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14

Baniecki, Mary Lynn, Dyann F. Wirth, and Jon Clardy. "High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery." Antimicrobial Agents and Chemotherapy 51, no. 2 (2006): 716–23. http://dx.doi.org/10.1128/aac.01144-06.

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ABSTRACT New therapeutic agents for the treatment of malaria, the world's most deadly parasitic disease, are urgently needed. Malaria afflicts 300 to 500 million people and results in 1 to 2 million deaths annually, and more than 85% of all malaria-related mortality involves young children and pregnant women in sub-Saharan Africa. The emergence of multidrug-resistant parasites, especially in Plasmodium falciparum, has eroded the efficacy of almost all currently available therapeutic agents. The discovery of new drugs, including drugs with novel cellular targets, could be accelerated with a who

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15

Hassan, S. U., K. Mahmoud, Z. Wigston, A. Burska, M. Y. MD Yusof, and E. Vital. "POS0175 ASSOCIATION BETWEEN BIOMARKERS AND THERAPEUTIC PATHWAY IN PATIENTS WITH SLE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 300.2–301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2467.

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Background:SLE is heterogeneous in clinical presentation, underlying immunology, and response to therapy. Patients with severe or resistant disease receive cyclophosphamide or rituximab. Although effective, late use of these therapies entails cumulative damage.Emerging predictors of response to rituximab include demographics, IFN-Scores and autoantibodies. For such predictors to change treatment strategy we need to understand their association with the effectiveness of other therapeutic options at earlier decision points.Prospective studies of treatment pathways are difficult to perform, requi

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16

Ujuamala Uloma Ezeani, Penaere Theresa Osahon, and Michael Chukwudi Ezeani. "Pattern of anti-malarial drugs and artemether combination therapy adherence in an institution based medical centre, Nigeria." World Journal of Advanced Research and Reviews 8, no. 3 (2020): 162–70. http://dx.doi.org/10.30574/wjarr.2020.8.3.0437.

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The change in policy guidelines for treating uncomplicated malaria became necessary because the therapeutic efficacy of chloroquine and SP had deteriorated. Hence compliance is a necessity to enable effective check on malaria. This work was carried out to evaluate antimalaria drug prescription and to update its usage in line with WHO guideline on Artemeter Combination therapy in a university based medical center. We utilized descriptive, cross-sectional, retrospective study of antimalaria prescriptions purposely carried out among male and female outpatients with mean age of 22.4±2.8 at a Unive

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Telgt, Denise S., Andre J. van der Ven, Barbara Schimmer, Han A. Droogleever-Fortuyn, and Robert W. Sauerwein. "Serious Psychiatric Symptoms after Chloroquine Treatment following Experimental Malaria Infection." Annals of Pharmacotherapy 39, no. 3 (2005): 551–54. http://dx.doi.org/10.1345/aph.1e409.

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OBJECTIVE: To report serious psychiatric symptoms after standard chloroquine treatment following human malaria infection induced for research. CASE SUMMARY: A 34-year-old healthy woman volunteered to participate in a study of malaria treatment. She was infected on day 0 with a chloroquine-susceptible strain of Plasmodium falciparum and was treated with a standard 3-day course of chloroquine from day 9 onward, following a positive blood smear (parasitemia 0.001%). On day 10, the blood smear became negative. On day 11, she developed a psychotic disorder not otherwise specified, most probably cau

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Iretiola Builders, Modupe, Joseph Oyepata Simeon, Timothy Olugbenga Ogundeko, and Philip Builders. "Antimalarial Drugs and COVID -19." Sumerianz Journal of Medical and Healthcare, no. 312 (December 15, 2020): 111–16. http://dx.doi.org/10.47752/sjmh.312.111.116.

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The coronavirus disease 2019 (COVID-19) is a novel virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that is ravaging the world. Therefore, the need to find new preventive and therapeutic drug at the earliest possible time additionally to the implementation of preventive measures such as early detection, isolation and treatment of cases as well as minimization of transmission through physical interaction. Moreover, specific vaccines and yet effective treatment that target the 2019. This review focuses on the use of antimalarial drugs as therapeutics interventions for

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Iretiola Builders, Modupe, Joseph Oyepata Simeon, Timothy Olugbenga Ogundeko, and Philip Builders. "Antimalarial Drugs and COVID -19." Sumerianz Journal of Medical and Healthcare, no. 312 (December 15, 2020): 111–16. http://dx.doi.org/10.47752/sjmh.312.111.116.

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The coronavirus disease 2019 (COVID-19) is a novel virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that is ravaging the world. Therefore, the need to find new preventive and therapeutic drug at the earliest possible time additionally to the implementation of preventive measures such as early detection, isolation and treatment of cases as well as minimization of transmission through physical interaction. Moreover, specific vaccines and yet effective treatment that target the 2019. This review focuses on the use of antimalarial drugs as therapeutics interventions for

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20

Bertoli, Federica, Daniele Veritti, Carla Danese, et al. "Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye." Journal of Ophthalmology 2020 (August 27, 2020): 1–9. http://dx.doi.org/10.1155/2020/4827304.

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The novel pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has challenged the medical community. While diagnostic and therapeutic efforts have been focused on respiratory complications of the disease, several ocular implications have also emerged. SARS-CoV-2 RNA has been found in tears of the infected patients, and reports suggest that the ocular surface could serve as a portal of entry and a reservoir for viral transmission. Clinically, COVID-19 has been associated with mild conjunctivitis, which can be the first and onl

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Manrique Julio, Elin, Belkis Palacio Villalba, Elías Alberto Bedoya Marrugo, and Marlene Duran Lengua. "Activity of the chloroquine/hydroxychloroquine and mefloquine in front of the SARS-CoV-2." International Journal of Radiology & Radiation Therapy 7, no. 4 (2020): 97–102. http://dx.doi.org/10.15406/ijrrt.2020.07.00273.

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Introduction: Identifying the main advances in the pharmacological and clinical management of the pandemic COVID-19 and SARS-CoV-2, the most recent and currently taking lives worldwide, is to priority of the scientific community that to date have rehearsed and joined efforts in order to respond with effective treatments that stop the progression of the viral infection and manage to recover the patient. Objective: To document available information on the effects of the antimalarials chloroquine / hydroxychloroquine and mefloquine in severe acute respiratory syndrome, generated by SARS CoV-2, ac

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Izaguirry, Aryele Pinto, Natasha Frasson Pavin, Melina Bucco Soares, et al. "Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats." Toxicology Research 5, no. 6 (2016): 1561–72. http://dx.doi.org/10.1039/c6tx00203j.

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Chibale, Kelly. "Economic drug discovery and rational medicinal chemistry for tropical diseases." Pure and Applied Chemistry 77, no. 11 (2005): 1957–64. http://dx.doi.org/10.1351/pac200577111957.

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In order to fulfill research objectives around target-based drug discovery in the field of anti-infective agents that are prevalent mainly in poor Third World countries, selection of biological and chemical targets is guided by economic drug discovery and rational medicinal chemistry. Selection of biological targets of therapeutic relevance in multiple disease-causing organisms, as well as the use of natural products and existing drugs as chemical scaffolds for the discovery and design of novel therapeutics should be viable strategies underpinning drug discovery research in poor Third World co

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Omara, Timothy. "Antimalarial Plants Used across Kenyan Communities." Evidence-Based Complementary and Alternative Medicine 2020 (June 12, 2020): 1–31. http://dx.doi.org/10.1155/2020/4538602.

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Malaria is one of the serious health problems in Africa, Asia, and Latin America. Its treatment has been met with chronic failure due to pathogenic resistance to the currently available drugs. This review attempts to compile phytotherapeutical information on antimalarial plants in Kenya based on electronic data. A comprehensive web search was conducted in multidisciplinary databases, and a total of 286 plant species from 75 families, distributed among 192 genera, were retrieved. Globally, about 139 (48.6%) of the species have been investigated for antiplasmodial (18%) or antimalarial activitie

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Kay, Katherine, Eva Maria Hodel, and Ian M. Hastings. "Improving the Role and Contribution of Pharmacokinetic Analyses in Antimalarial Drug Clinical Trials." Antimicrobial Agents and Chemotherapy 58, no. 10 (2014): 5643–49. http://dx.doi.org/10.1128/aac.02777-14.

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ABSTRACTIt is now World Health Organization (WHO) policy that drug concentrations on day 7 be measured as part of routine assessment in antimalarial drug efficacy trials. The rationale is that this single pharmacological measure serves as a simple and practical predictor of treatment outcome for antimalarial drugs with long half-lives. Herein we review theoretical data and field studies and conclude that the day 7 drug concentration (d7c) actually appears to be a poor predictor of therapeutic outcome. This poor predictive capability combined with the fact that many routine antimalarial trials

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Bredemeier, M., A. Duarte, M. Pinheiro, et al. "POS0676 SURVIVAL OF THE FIRST COURSE OF BIOLOGIC OR JAK INHIBITOR IN RHEUMATOID ARTHRITIS: ASSOCIATION WITH THE CHOICE OF AGENT AND CONCOMITANT CONVENTIONAL SYNTHETIC DMARDS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 582.2–583. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3841.

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Background:After failure of conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) in the therapy of rheumatoid arthritis (RA), treatment may be escalated to biologic (bDMARDs) or JAK inhibitors (JAKi) (1). Analysis of drug survival can provide useful information on the effectiveness of these therapeutic schemes.Objectives:to evaluate the association of the choice of therapeutic agent with the survival of treatment course in RA patients receiving their first bDMARD or JAKi.Methods:BiobadaBrasil is a multicentric registry-based cohort study of Brazilian patients starting their

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Green, Peter J., and Sylvia Pasternak. "Hypertrophic and Ulcerated Discoid Lupus Erythematosus." Journal of Cutaneous Medicine and Surgery 16, no. 6 (2012): 453–57. http://dx.doi.org/10.1177/120347541201600620.

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Background: Hypertrophic lupus is an uncommon clinical variant of chronic cutaneous lupus that remains a challenge to treat. A 45-year-old female day-care worker with long-standing lupus presented with hypertrophic cutaneous involvement on the dorsal hand, elbow, and toe of 6 years' duration. Treatmentsincluded monotherapy with either hydroxychloroquine or chloroquine and potent topical and intralesional steroid injection. Systemic chemotherapy with R–CHOP chemotherapy for stage IIA diffuse large B-cell lymphoma did not clear the skin findings. Objective: To review the clinical presentation an

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Dauda Muhammed, Yetunde H. Adebiyi, Bernard O. Odey, et al. "Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties." GSC Advanced Research and Reviews 6, no. 3 (2021): 035–43. http://dx.doi.org/10.30574/gscarr.2021.6.3.0024.

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There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and has been used for centuries in the Ayurvedic system of medicine for the treatments of various diseases. The present review provides detailed description on the distribution, ethno-medicinal use, phyto-constituents, and biological properties of the plant that justifies its use as a potential therapeutic agent in management of different diseases. The phyto chemical composition of Dennettia tripetala include alkaloids, tannins, saponins, flavon

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BERNATSKY, SASHA, CHRISTINE PESCHKEN, PAUL R. FORTIN, et al. "Medication Use in Systemic Lupus Erythematosus." Journal of Rheumatology 38, no. 2 (2010): 271–74. http://dx.doi.org/10.3899/jrheum.100414.

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Objective.To evaluate factors affecting therapeutic approaches used in clinical practice for the management of systemic lupus erythematosus (SLE), in a multicenter cohort.Methods.We combined data from 10 clinical adult SLE cohort registries in Canada. We used multivariate generalized estimating equation methods to model dichotomized outcomes, running separate regressions where the outcome was current exposure of the patient to specific medications. Potential predictors of medication use included demographic (baseline age, sex, residence, race/ethnicity) and clinical factors (disease duration,

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Dziekan, Jerzy M., Han Yu, Dan Chen, et al. "Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay." Science Translational Medicine 11, no. 473 (2019): eaau3174. http://dx.doi.org/10.1126/scitranslmed.aau3174.

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Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use. Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved understanding of their MoAs and associated resistance mechanisms. In the present work, we implemented the cellular thermal shift assay coupled with mass spectrometry (MS-CETSA) for drug target identification inPlasmodium falciparum, the main causative agent of human malaria. We validated the efficacy of this approach for pyrimethamine, a folic acid antagonist, and E64d, a broad-spectrum cysteine proteinase inhibi

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Kuhen, Kelli L., Arnab K. Chatterjee, Matthias Rottmann, et al. "KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission." Antimicrobial Agents and Chemotherapy 58, no. 9 (2014): 5060–67. http://dx.doi.org/10.1128/aac.02727-13.

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ABSTRACTRenewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the previously reported activity profile of this series, the clinical candidate KAF156 shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM agains

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Lourens, Chris, Niklas Lindegardh, Karen I. Barnes, et al. "Benefits of a Pharmacology Antimalarial Reference Standard and Proficiency Testing Program Provided by the Worldwide Antimalarial Resistance Network (WWARN)." Antimicrobial Agents and Chemotherapy 58, no. 7 (2014): 3889–94. http://dx.doi.org/10.1128/aac.02362-14.

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ABSTRACTComprehensive assessment of antimalarial drug resistance should include measurements of antimalarial blood or plasma concentrations in clinical trials and in individual assessments of treatment failure so that true resistance can be differentiated from inadequate drug exposure. Pharmacometric modeling is necessary to assess pharmacokinetic-pharmacodynamic relationships in different populations to optimize dosing. To accomplish both effectively and to allow comparison of data from different laboratories, it is essential that drug concentration measurement is accurate. Proficiency testin

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Sharma, Diksha, Kushal K. Bansal, Archana Sharma, Meenakshi Pathak, and Prabodh C. Sharma. "A Brief Literature and Review of Patents on Thiazole Related Derivatives." Current Bioactive Compounds 15, no. 3 (2019): 304–15. http://dx.doi.org/10.2174/1573407214666180827094725.

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Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal chemistry research. Significance of thiazole compounds are well documented as thiazole is an obligatory structure of number of currently available therapeutics. In spite of that, thiazole derivatives are endowed with myriad biological activities, such as antiviral, anticancer, antibacterial, antifungal, antimalarial, antiparkinsonian, anti-inflammatory activities and many more. Methods: In recent past, different approaches have been introduced for synthesis of thiazole and related compounds. Intrinsic

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Kumari, Isha, Hemlata Kaurav, and Gitika Chaudhary. "Ethnobotanical Significance of Picrorhiza Kurroa (Kutki), a Threatened Species." International Journal of Research and Review 8, no. 4 (2021): 363–75. http://dx.doi.org/10.52403/ijrr.20210443.

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Herbal plants have been used in the health maintenance customs since the origin of mankind. The herbal products have negligible adverse impacts on the consumer health because they have suitable and beneficial physiological actions on the living systems. Traditional systems of medication primarily use plants in their practices. The market demand of these plant based products has been increased over the past few years. Picrorhiza kurroa Royle ex Benth is one of the most established herbal plants with extraordinary medicinal properties. It belongs to Scrophulariaceae family and commonly called as

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Ouji, Manel, Guillaume Barnoin, Álvaro Fernández Álvarez, et al. "Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites." Molecules 25, no. 12 (2020): 2817. http://dx.doi.org/10.3390/molecules25122817.

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The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health. Therefore, the development of new antimalarial drugs or combinations is urgently required. In this context, several hybrid molecules combining a dihydroartemisinin derivative and gold(I) N-heterocyclic carbene (NHC) complexes have been synthesized based on the different modes of action of the two compounds. The antiplasmodial activity of these molecules was assessed in vitro as well as their cytotoxicity aga

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Teka, Tekleab, Tadesse Awgichew, and Haile Kassahun. "Antimalarial Activity of the Leaf Latex of Aloe weloensis (Aloaceae) against Plasmodium berghei in Mice." Journal of Tropical Medicine 2020 (August 14, 2020): 1–7. http://dx.doi.org/10.1155/2020/1397043.

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Background. Emergence of drug resistance and lack of therapeutic efficacy of modern antimalarial drugs are the most triggering factors for the searching of new lead compounds with different mechanisms of action. Medicinal plants with documented traditional uses are a viable option for treatment of malaria. Traditionally, the leaf latex of Aloe weloensis has been used in the treatment of malaria in Ethiopia. Hence, this study was undertaken to investigate the antimalarial activity of the leaf latex of Aloe weloensis in Plasmodium berghei-infected mice. Methods. A four-day suppressive test was e

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Sevilla-Castillo, Fernando, Oscar J. Roque-Reyes, Fernanda Romero-Lechuga, et al. "Both Chloroquine and Lopinavir/Ritonavir Are Ineffective for COVID-19 Treatment and Combined Worsen the Pathology: A Single-Center Experience with Severely Ill Patients." BioMed Research International 2021 (February 6, 2021): 1–12. http://dx.doi.org/10.1155/2021/8821318.

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The off-label use of antiviral and antimalarial drugs has been considered by many researchers as a fast and relatively safe alternative to provide therapeutic options to treat COVID-19, but the assessment of such drug-specific effectiveness in this regard is far from complete. Especially, the current body of knowledge about COVID-19 therapeutics needs more data regarding drug effectiveness and safety in the severely ill patients with comorbidities. In the present article, we retrospectively analyze data from 61 patients that received treatment with chloroquine, lopinavir/ritonavir, both drugs

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Vale, Valdicley Vieira, Dayse Lúcia do Nascimento Brandão, Milena Cristina Martins Da Silva, et al. "Malaria parasite resistance vicious cycle." Revista Eletrônica Acervo Saúde 11, no. 18 (2019): e1708. http://dx.doi.org/10.25248/reas.e1708.2019.

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Objective: This paper analyzes the "vicious" cycle of malaria treatment as a consequence of restricted access to anti-malarial drugs. Literature review: Lack of public health policies in affected countries limits access to medicines. This leads patients to acquire drugs in "parallel" markets under the risk of quality deviations or falsified products. The use of these products can aggravate the disease, lead to death, and contribute to parasite resistance to drugs. There are reports of Plasmodium strains resistant to different antimalarial drugs, this creates the need to look for new therapeuti

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Deharde, Daniela, Walter Klockenbusch, Ralf Schmitz, Marcus Brand, Helen Ann Köster, and Kathrin Oelmeier de Murcia. "Hydroxychloroquine as a Preventive and Therapeutic Option in Preeclampsia – a Literature Review." Geburtshilfe und Frauenheilkunde 80, no. 07 (2020): 679–85. http://dx.doi.org/10.1055/a-1170-5145.

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AbstractPreeclampsia is one of the most feared complications of pregnancy and puerperium and represents a serious threat to mother and child. In addition, a history of preeclampsia increases the risk of future cardiovascular events. New diagnostic and therapeutic approaches are needed. New therapeutic options are currently being discussed, one of which is the administration of hydroxychloroquine. It is an antimalarial drug which is also used to treat rheumatological disease and its use in pregnancy is considered safe. A reduced incidence of preeclampsia in patients with selected rheumatologica

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Amit Reche, Rishikesh Kolse, Simran Gupta, Ajinkya Ingle, and Kumar Gaurav Chhabra. "Therapeutic options for Covid – 19 : Pandemic – A Review." International Journal of Research in Pharmaceutical Sciences 11, SPL1 (2020): 420–24. http://dx.doi.org/10.26452/ijrps.v11ispl1.2802.

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Covid-19 is an outbreak of a severe acute respiratory disorder which emerged in December 2019 in Wuhan, China. Since then the virus has spread to many countries and has become and pandemic. The mortality rate of the disease is very high but it varies from country to country depending on the medical facilities and the observance of isolation among the population. As the disease is very contagious many different treatment modalities have been tried. The therapeutic methods which are used are Ayurvedic and homeopathic along with that some Allopathic drugs are also used. Ayurvedic and homeopathy w

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Silva, Lusinalva Leonardo da, Renata de Almeida, Fabiana Texeira e. Silva, and Maurício Afonso Verícimo. "Review on the therapeutic activities of the genus Trichilia." Research, Society and Development 10, no. 5 (2021): e29610514916. http://dx.doi.org/10.33448/rsd-v10i5.14916.

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The genus Trichilia (Meliaceae family) has been attracting interest among Brazilian Flora, due to the biological activities of its secondary metabolites. This genus has species distributed throughout tropical America, recognized for its significant economic importance and high commercial value. Its composition consists mainly of terpenoids (triterpenes, sesquiterpenes, limonoids and steroids) and polyphenols (flavonoids and tannins). In folk medicine this genus is used in preparations such as antimicrobial, antimalarial, antiviral and antioxidant. Studies carried out with several species of th

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Salako, Olanrewaju A., and Olufunsho Awodele. "Evaluation of the antimalarial activity of the aqueous leaf extract of Gossypium barbadense (Malvaeceae) in mice." Drugs and Therapy Studies 2, no. 1 (2012): 2. http://dx.doi.org/10.4081/dts.2012.e2.

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Some medicinal plants have been shown to have antimalarial activity when used as combination therapy. <em>Gossypium barbadense</em> has been used by herbal medicine practitioners in combination with other herbs, and as a monotherapy in the treatment of malarial infection. The study was, therefore, aimed at evaluating the antimalarial effect of the aqueous leaf extract of <em>G. barbadense</em> using mice infected with <em>P. berghei</em>. The suppressive effect was evaluated by administering 25 mice divided into five groups with 250, 500, and 1,000 mg/kg of

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Imaga, Ngozi Awa. "Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/269659.

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Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the humanβ-globin subunit results in replacement ofβ6 glutamic acid by valine, leading to the devastating clinical manifestations of sickle cell disease. This substitution causes drastic reduction in the solubility of sickle cell hemoglobin (HbS) when deoxygenated. Under these conditions, the HbS molecules polymerize to form long crystalline intracellular mass of fibers which are responsible for the deformation of the biconca

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C., Ramya, Vishnu AS, and Nasila K. "A Review: Cyanthillium cinereum (L) H. Rob." International Journal of Research and Review 8, no. 9 (2021): 99–101. http://dx.doi.org/10.52403/ijrr.20210914.

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Cyanthillium cinereum (L) H. Rob (family Asteraceae) is also known as Poovamkurunnila in Malayalam. It is commonly found as a weed throughout in India. Cyanthillium cinereum is an annual herb with hairy stem, up to 12-75 cm height. The leaves are simple, alternate, ovate-elliptic or acute, irregularly dentate or crenate-serrate and hairy. Cyanthillium cinereum is an annual herb, contains various phytochemicals like cardiac glycosides, phenols, flavonoids, steroids, tannins, saponins and phlobatannins etc. Due to the presence of these phytochemicals Cyanthillium cinereum exhibits various activi

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Ishtiyaq, Ahmad, ABRAR ALAM, Javed Inam Siddiqui, and Munawwar Husain Kazmi. "Therapeutic Potential of Widely Used Unani Drug Asl-Us-Soos (Glycyrrhiza glabra Linn.): A Systematic Review." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 765–73. http://dx.doi.org/10.22270/jddt.v9i4-s.3318.

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Plants have been one of the important sources of therapeutics or other human health benefits since the beginning of human civilization throughout history. Currently, there is increasing awareness and general acceptability of the use of herbs, as a medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Traditional system of medicine including Ayurveda, Unani, and Siddha etc. contributed in Health care dealing worldwide. The Unani system of medicine (USM) is an age old system of medicine which has a holistic approach to treat various kind of disease; most of the time the d

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Mahajan, Akhil, and Tejpal Singh Chundawat. "Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate." Mini-Reviews in Organic Chemistry 16, no. 7 (2019): 631–52. http://dx.doi.org/10.2174/1570193x15666181001142122.

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Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Q

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Simpson, Julie A., Emmeline R. Watkins, Ric N. Price, Leon Aarons, Dennis E. Kyle, and Nicholas J. White. "Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance." Antimicrobial Agents and Chemotherapy 44, no. 12 (2000): 3414–24. http://dx.doi.org/10.1128/aac.44.12.3414-3424.2000.

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ABSTRACT Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations of antimalarial drug which are sufficient to eradicate the more sensitive parasites but not those with the resistance mutation(s). Mefloquine, a slowly eliminated quinoline-methanol compound, is the most widely used drug for the treatment of multidrug-resistant falciparum malaria. It has been used at doses ranging between 15 and 25 mg of base/kg of body weight. Resistance to mefloquine has developed rapidly on the borders of Thailand, where the drug has bee

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Mandt, Rebecca E. K., Maria Jose Lafuente-Monasterio, Tomoyo Sakata-Kato, et al. "In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model." Science Translational Medicine 11, no. 521 (2019): eaav1636. http://dx.doi.org/10.1126/scitranslmed.aav1636.

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Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in clinical use, prompting the need to characterize the pathways mediating resistance. Here, we report a framework for assessing development of resistance of Plasmodium falciparum to new antimalarial therapeutics. We investigated development of resistance by P. falciparum to the dihydroorotate dehydrogenase (DHODH) inhibitors DSM265 and DSM267 in tissue culture and in a mouse model of P. falciparum infection. We found that resistance to these drugs arose rapidly both in vitro and in vivo. We identified 13 point

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Manirakiza, Alexandre, Siméon Pierre Njuimo, Alain Le Faou, Denis Malvy, and Pascal Millet. "Availability of Antimalarial Drugs and Evaluation of the Attitude and Practices for the Treatment of Uncomplicated Malaria in Bangui, Central African Republic." Journal of Tropical Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/510834.

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National malaria management policy is based upon the availability of effective and affordable antimalarial drugs. This study was undertaken to evaluate the quality of the treatment of uncomplicated malaria cases in Bangui, an area with multidrug-resistant parasites, at a time preceding implementation of a new therapeutic policy relying on the artemisinin derivative combined treatment artemether-lumefantrine. A cross-sectional study was carried out in Bangui city to assess availability of antimalarial drugs and the performances of health workers in the management of uncomplicated malaria. Avail

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Okereke, Chukwuemeka S. "Management of HIV-infected pregnant patients in malaria-endemic areas: Therapeutic and safety considerations in concomitant use of antiretroviral and antimalarial agents." Clinical Therapeutics 21, no. 9 (1999): 1456–96. http://dx.doi.org/10.1016/s0149-2918(00)80004-1.

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