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Journal articles on the topic 'Antimalarials'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kwofie, Samuel K., Emmanuel Broni, Bismark Dankwa, et al. "Review of Atypical Organometallic Compounds as Antimalarial Drugs." Journal of Chemistry 2020 (May 20, 2020): 1–9. http://dx.doi.org/10.1155/2020/9414093.

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Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in compa

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2

Esdaile, John M. "The Efficacy of Antimalarials in Systemic Lupus Erythematosus." Lupus 2, no. 1_suppl (1993): 3–8. http://dx.doi.org/10.1177/0961203393002001021.

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The use of antimalarial drugs to treat systemic lupus erythematosus (SLE) is reviewed regarding their value in SLE of mild-to-moderate disease activity, as corticosteroid-sparing agents, and as an adjunctive therapy in severe SLE. A retrospective controlled study of a variety of antimalarials and a randomized discontinuation trial of hydroxychloroquine support the considerable clinical belief that antimalarials are of benefit in mild-to-moderate SLE. Anecdotal reports and the opinion of experienced clinicians suggest that antimalarials permit the use of lower doses of corticosteroids. No contr

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3

Edgar, Muhindo. "Combating Malaria with Plant-Based Antimalarials: A Comparative Study." Research Output Journal of Public Health and Medicine 4, no. 2 (2024): 18–22. http://dx.doi.org/10.59298/rojphm/2024/421822.

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Malaria remains a leading global health threat, especially in low-income regions such as Sub-Saharan Africa, where traditional antimalarial treatments face increasing challenges due to drug resistance. Artemisinin-based combination therapies (ACTs) have long been the primary frontline treatment; however, escalating resistance in Plasmodium species has prompted researchers to investigate alternative solutions, including plant-derived antimalarials. This study examines the efficacy and safety of plant-based antimalarial compounds, particularly Artemisia annua, compared to synthetic drugs, consid

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Evans, Daniel R., Colleen R. Higgins, Sarah K. Laing, Phyllis Awor, and Sachiko Ozawa. "Poor-quality antimalarials further health inequities in Uganda." Health Policy and Planning 34, Supplement_3 (2019): iii36—iii47. http://dx.doi.org/10.1093/heapol/czz012.

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Abstract Substandard and falsified medications are a major threat to public health, directly increasing the risk of treatment failure, antimicrobial resistance, morbidity, mortality and health expenditures. While antimalarial medicines are one of the most common to be of poor quality in low- and middle-income countries, their distributional impact has not been examined. This study assessed the health equity impact of substandard and falsified antimalarials among children under five in Uganda. Using a probabilistic agent-based model of paediatric malaria infection (Substandard and Falsified Ant

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Agbo, Chinonyelum Emmanuel, Uzochukwu Emmanuel Chima, Sunday Chibueze Ogbobe, Faith Olanrewaju Omotayo, and Success Chekwubechukwu David. "Transdermal antimalarial drug delivery to improve poor adherence to antimalarials: A new light at the end of the tunnel." American Journal of Biopharmacy and Pharmaceutical Sciences 3 (December 2, 2023): 4. http://dx.doi.org/10.25259/ajbps_14_2023.

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Malaria, a perilous disease caused by Plasmodium parasites and characterized by a substantial mortality rate, has persistently posed as a global health challenge. Conventional antimalarial formulations, although effective, grapple with issues surrounding their bioavailability and palatability, and potentially hampering patient adherence and inadvertently fueling drug resistance and poor treatment outcomes. This paper meticulously delves into the predicaments associated with prevailing antimalarial delivery methods – oral, intravenous, and intramuscular. The paper navigates through the compelli

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6

Zieliński, Ewa, Marek Kowalczyk, Karolina Osowiecka, Łukasz Klepacki, Łukasz Dyśko, and Katarzyna Wojtysiak. "The Problem of Antimalarial-Drug Abuse by the Inhabitants of Ghana." Medicina 59, no. 2 (2023): 257. http://dx.doi.org/10.3390/medicina59020257.

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Introduction: Malaria is still a huge social and economic health problem in the world. It especially affects the developing countries of Africa. A particular problem is the misuse and abuse of over-the-counter antimalarials. This problem could lead to the emergence of drug-resistant strains and the subsequent elimination of more antimalarials from the list of effective antimalarials in Ghana. Methods: During the implementation of the study, an original questionnaire was used to collect data among Ghanaians on their knowledge of malaria, attitude towards antimalarials and their use of antimalar

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7

Opsenica, Igor, Dejan Opsenica, Milka Jadranin, et al. "On peroxide antimalarials." Journal of the Serbian Chemical Society 72, no. 12 (2007): 1181–90. http://dx.doi.org/10.2298/jsc0712181o.

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Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synt

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8

Heppner, DG, PE Hallaway, GJ Kontoghiorghes, and JW Eaton. "Antimalarial properties of orally active iron chelators." Blood 72, no. 1 (1988): 358–61. http://dx.doi.org/10.1182/blood.v72.1.358.358.

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Abstract The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxamine, the necessity for parenteral administration. The investigators now report that a new class of orally active iron chelators, namely the derivatives of alpha- ketohydroxypyridines (KHPs), are

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9

Heppner, DG, PE Hallaway, GJ Kontoghiorghes, and JW Eaton. "Antimalarial properties of orally active iron chelators." Blood 72, no. 1 (1988): 358–61. http://dx.doi.org/10.1182/blood.v72.1.358.bloodjournal721358.

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The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxamine, the necessity for parenteral administration. The investigators now report that a new class of orally active iron chelators, namely the derivatives of alpha- ketohydroxypyridines (KHPs), are potent an

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10

Zheng, Dan, Tingting Liu, Shasha Yu, Zhilong Liu, Jing Wang, and Ying Wang. "Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives." Tropical Medicine and Infectious Disease 9, no. 9 (2024): 223. http://dx.doi.org/10.3390/tropicalmed9090223.

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Artemisinin is an endoperoxide sesquiterpene lactone isolated from Artemisia annua and is often used to treat malaria. Artemisinin’s peroxide bridge is the key structure behind its antimalarial action. Scientists have created dihydroartemisinin, artemether, artesunate, and other derivatives preserving artemisinin’s peroxide bridge to increase its clinical utility value. Artemisinin compounds exhibit excellent efficacy, quick action, and minimal toxicity in malaria treatment and have greatly contributed to malaria control. With the wide and unreasonable application of artemisinin-based medicine

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11

Yousif, M. A., and A. A. Adeel. "Antimalarials prescribing patterns in Gezira state: precepts and practices." Eastern Mediterranean Health Journal 6, no. 5-6 (2000): 939–47. http://dx.doi.org/10.26719/2000.6.5-6.939.

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A longitudinal pharmacoepidemiological study on prescribing patterns of antimalarials was conducted in Gezira State, Sudan. Different core drug prescribing indicators were identified, measured and correlated. Chloroquine and quinine were the most frequently prescribed antimalaria drugs but in 44.7% of cases, the dosage was inappropriate and did not conform to standard regimens. Due to variable and unmonitored patterns of drug resistance, most medical practitioners in Sudan tend to follow their own protocols to treat severe cases of malaria rather than conforming to standard regimens. We attrib

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12

Tang, Yu-Qing, Qian Ye, He Huang, and Wei-Yi Zheng. "An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance." Current Molecular Medicine 20, no. 8 (2020): 583–92. http://dx.doi.org/10.2174/1566524020666200207123253.

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: Malaria is one of the three most deadly infectious diseases in the world and seriously endangers human health and life. To reduce the public health burden of this disease, scientists have focused on the discovery and development of effective antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its derivatives, which all play a profound role in the treatment of malaria. However, drugresistant strains of Plasmodium falciparum have emerged due to frequent use of antimalarials and have become increasingly resistant to existing antimalarial drugs, causing disastrous

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13

Triatmoko, Bawon, Dwi Koko Pratoko, Antonius Nugraha Widhi Pratama, Yoshinta Debi Purnomo, Tinton Agung Laksono, and Ari Satia Nugraha. "Preliminary Study on Antimalarial Agent From Indonesian Swietenia Mahagoni and Kibatalia Arborea." Proceedings of the International Conference on Green Technology 10 (December 31, 2019): 13. http://dx.doi.org/10.18860/icgt.v10i0.1113.

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Malaria is a global public health concern due to the increase of resistance to antimalarials, therefore the search for new antimalarials is of importance. This study was conducted to explore the antimalarial activity of Swietenia mahagoni and Kibatalia arborea in the form of crude methanolic extract. The plants were collected from Klaten-Central Java, and Batu-East Java, Indonesia. In vitro antimalarial assay was done against Plasmodium falciparum. Phytochemical studies were done chemically using Dragendorff’s reagent and spectroscopically using the 1H-NMR technique. Results show that the extr

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14

Creek, Darren J., Eileen Ryan, William N. Charman, et al. "Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin." Antimicrobial Agents and Chemotherapy 53, no. 8 (2009): 3496–500. http://dx.doi.org/10.1128/aac.00363-09.

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ABSTRACT Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction of selected peroxide antimalarials with oxyhemoglobin, the most abundant form of iron in the human body. The observed stability of artemisinin derivatives and 1,2,4-trioxolanes in the presence of oxyhemoglobin was in contrast to previous reports in the literature. Spectros

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15

Van Tyne, Daria, Alessandro D. Uboldi, Julie Healer, Alan F. Cowman, and Dyann F. Wirth. "Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs." Antimicrobial Agents and Chemotherapy 57, no. 7 (2013): 2937–41. http://dx.doi.org/10.1128/aac.02574-12.

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ABSTRACTMalaria's ability to rapidly adapt to new drugs has allowed it to remain one of the most devastating infectious diseases of humans. Understanding and tracking the genetic basis of these adaptations are critical to the success of treatment and intervention strategies. The novel antimalarial resistance locusPF10_0355(Pfmspdbl2) was previously associated with the parasite response to halofantrine, and functional validation confirmed that overexpression of this gene lowered parasite sensitivity to both halofantrine and the structurally related antimalarials mefloquine and lumefantrine, pre

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16

Issaka, Mariama, Adamou Salissou, Ibrahim Arzika, et al. "Ex VivoResponses of Plasmodium falciparum Clinical Isolates to Conventional and New Antimalarial Drugs in Niger." Antimicrobial Agents and Chemotherapy 57, no. 7 (2013): 3415–19. http://dx.doi.org/10.1128/aac.02383-12.

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ABSTRACTLittle is known about resistance ofPlasmodium falciparumto antimalarials in Sahelian countries. Here we investigated the drug susceptibilities of fresh isolates collected in Niger post-deployment of artemisinin-based combination therapies (ACTs). We found that the parasites remained highly susceptible to new (dihydroartemisinin, lumefantrine, pyronaridine, and piperaquine) and conventional (amodiaquine and chloroquine) antimalarial drugs. The introduction of ACTs in 2005 and their further deployment nationwide have therefore not resulted in a decrease inP. falciparumsusceptibilities to

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17

Egwu, Chinedu Ogbonnia, Nwogo Ajuka Obasi, Chinyere Aloke, et al. "Impact of Drug Pressure versus Limited Access to Drug in Malaria Control: The Dilemma." Medicines 9, no. 1 (2022): 2. http://dx.doi.org/10.3390/medicines9010002.

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Malaria burden has severe impact on the world. Several arsenals, including the use of antimalarials, are in place to curb the malaria burden. However, the application of these antimalarials has two extremes, limited access to drug and drug pressure, which may have similar impact on malaria control, leading to treatment failure through divergent mechanisms. Limited access to drugs ensures that patients do not get the right doses of the antimalarials in order to have an effective plasma concentration to kill the malaria parasites, which leads to treatment failure and overall reduction in malaria

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18

Nayak, V., and Jm Esdaile. "The efficacy of antimalarials in systemic lupus erythematosus." Lupus 5, no. 1_suppl (1996): 23–27. http://dx.doi.org/10.1177/0961203396005001061.

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The use of antimalarial drugs to treat systemic lupus erythematosus (SLE) is receiving increased attention. A retrospective controlled study suggested that antimalarials were useful in suppressing disease activity in SLE. A randomized discontinuation trial of hydroxychloroquine sulphate supported the clinical belief that antimalarials are of benefit in SLE of mild to moderate disease activity and might have a role as adjunctive therapy to protect against more severe relapses of SLE. A randomized trial of the ability of hydroxychloroquine sulphate to suppress articular manifestations of SLE dem

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19

Manirakiza, Alexandre, Georges Soula, Remi Laganier, et al. "Pattern of the Antimalarials Prescription during Pregnancy in Bangui, Central African Republic." Malaria Research and Treatment 2011 (July 15, 2011): 1–4. http://dx.doi.org/10.4061/2011/414510.

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Introduction. The aim of this study was to identify the antimalarials prescribed during the pregnancy and to document their timing. Method. From June to September 2009, a survey was conducted on 565 women who gave birth in the Castors maternity in Bangui. The antenatal clinics cards were checked in order to record the types of antimalarials prescribed during pregnancy according to gestational age. Results. A proportion of 28.8% ANC cards contained at least one antimalarial prescription. The commonest categories of antimalarials prescribed were: quinine (56.7%), artemisinin-based combinations (

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Duncan, MR, and HA Capell. "The use of antimalarials in combination with other disease modifying agents in RA – the British experience." Lupus 5, no. 1_suppl (1996): 50–58. http://dx.doi.org/10.1177/0961203396005001121.

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Antimalarial drugs are effective disease modifying agents in RA with a low incidence of serious toxic effects. Recently, combinations of second-line agents have been used in RA in attempts to treat patients with no response to a number of single agents, or suboptimal response to a single agent. Combinations of drugs have been selected for maximum efficacy and minimum toxicity, but clinical trials are difficult to design and interpret. In particular, ensuring adequate power to detect small differences in response poses a major problem. Antimalarials are an attractive choice for combination ther

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Ezedom, Theresa, Innocent Onyesom, Prosper Ejiro Awhin, Chinwendu Obogheneophruhe Elu, and Joy Onyewonuwa Acha. "PROFILING OF PHYLLANTHUS AMARUS PHYTOCHEMICAL CONSTITUENTS AND EVALUATION OF ASSOCIATED ANTIMALARIAL ACTIVITY AND ANTIOXIDANT POTENTIAL IN EXPERIMENTAL MICE." EPH - International Journal of Biological & Pharmaceutical Science 9, no. 1 (2023): 4–12. http://dx.doi.org/10.53555/eijbps.v9i1.40.

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The failing curative ability of antimalarials has prompted an open discussion for the use of antioxidants in combination with antimalarials for effective chemotherapy. This study profiled the phytochemical constituents of Phyllanthus amarus and evaluated their antimalarial and antioxidant activities. Phytochemical screening, antimalarial and acute oral toxicity were determined according to standard procedures. Blood antioxidant activity was assessed by measuring antioxidant enzymes and nitric oxide (NO), concentrations of malarial infected mice treated with P. amarus phytochemicals. Alkaloids,

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Fang, Yaqun, Xiaoqin He, Pengcheng Zhang, et al. "In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin." Toxins 11, no. 7 (2019): 379. http://dx.doi.org/10.3390/toxins11070379.

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Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity. In the in vitro antiplasmodial assay, LZ1 showed strong suppression of blood stage Plasmodium falciparum (P. falciparum) with an IC50 value of 3.045 μM. In the in vivo antiplasmodial assay, LZ1 exerted a significant antimalarial activity against Plasmodium berghei (P. berghei) in a dose- and a time- dependent manner. In addition, LZ1 exhibited anti-in

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23

Fernández, Diana, César Segura, Margarita Arboleda, Giovanny Garavito, Silvia Blair, and Adriana Pabón. "In VitroSusceptibility of Plasmodium vivax to Antimalarials in Colombia." Antimicrobial Agents and Chemotherapy 58, no. 11 (2014): 6354–59. http://dx.doi.org/10.1128/aac.03191-14.

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ABSTRACTThein vitrosusceptibilities of 30 isolates ofPlasmodium vivaxto a number of antimalarials (chloroquine [CQ], mefloquine, amodiaquine, quinine, and artesunate [AS]) were evaluated. The isolates came from the region of Urabá in Colombia, in which malaria is endemic, and were evaluated by the schizont maturation test. The 50% inhibitory concentration (IC50) was 0.6 nM (95% confidence interval [CI], 0.3 to 1.0 nM) for artesunate, 8.5 nM (95% CI, 5.6 to 13.0 nM) for amodiaquine, 23.3 nM (95% CI, 12.4 to 44.1 nM) for chloroquine, 55.6 nM (95% CI, 36.8 to 84.1 nM) for mefloquine, and 115.3 nM

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MODUPE IRETIOLA BUILDERS. "The potency of plant antimalarial." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 190–99. http://dx.doi.org/10.30574/wjbphs.2022.12.1.0113.

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Malaria has remained a major cause of morbidity and mortality in all parts of the world. It is associated with high economic burden on the nation, high prevalence of mortality in children, pregnant women and non-immune individuals, thus malaria is a global public health problem. This protozoan infection is mainly characterized by fever, pains, loss of appetite and anaemia, researchers had discovered potent antimalarial drugs mainly from plant sources in order to overcome resistance of antimalarials, vectors, inability to develop malarial vaccines and also toxic effects of conventional antimala

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Piscianz, Elisa, Eva Cuzzoni, Rajan Sharma, Alessandra Tesser, Pooja Sapra, and Alberto Tommasini. "Reappraisal of Antimalarials in Interferonopathies: New Perspectives for Old Drugs." Current Medicinal Chemistry 25, no. 24 (2018): 2797–810. http://dx.doi.org/10.2174/0929867324666170911162331.

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The story of antimalarials as antinflammatory drugs dates back several centuries. Chinin, the extract of the Cinchona bark, has been exploited since the 18th century for its antimalarial and antifebrile properties. Later, during the Second World War, the broad use of antimalarials allowed arguing their antirheumatic effect on soldiers. Since then, these drugs have been broadly used to treat Systemic Lupus Erythematosus, but, only recently, have the molecular mechanisms of action been partly clarified. <p> Inhibitory action on vacuole function and trafficking has been considered for decad

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Sukhoverkov, Kirill V., Maxime G. Corral, Julie Leroux, et al. "Improved herbicide discovery using physico-chemical rules refined by antimalarial library screening." RSC Advances 11, no. 15 (2021): 8459–67. http://dx.doi.org/10.1039/d1ra00914a.

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Trawling hundreds of antimalarials for herbicides, we develop a weighted scoring system for the phys-chem ‘rules’ of herbicide-likeness. Using this, we discover the antimalarial MMV1206386 is herbicidal via a novel mode of action.

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Dembele, Laurent, Yaw Aniweh, Nouhoum Diallo, et al. "Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali." Journal of Antimicrobial Chemotherapy 76, no. 8 (2021): 2079–87. http://dx.doi.org/10.1093/jac/dkab133.

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Abstract Objectives To evaluate Plasmodium malariae susceptibility to current and lead candidate antimalarial drugs. Methods We conducted cross-sectional screening and detection of all Plasmodium species malaria cases, which were nested within a longitudinal prospective study, and an ex vivo assessment of efficacy of a panel of antimalarials against P. malariae and Plasmodium falciparum, both PCR-confirmed mono-infections. Reference compounds tested included chloroquine, lumefantrine, artemether and piperaquine, while candidate antimalarials included the imidazolopiperazine GNF179, a close ana

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Calic, Petar P. S., Mahta Mansouri, Peter J. Scammells, and Sheena McGowan. "Driving antimalarial design through understanding of target mechanism." Biochemical Society Transactions 48, no. 5 (2020): 2067–78. http://dx.doi.org/10.1042/bst20200224.

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Malaria continues to be a global health threat, affecting approximately 219 million people in 2018 alone. The recurrent development of resistance to existing antimalarials means that the design of new drug candidates must be carefully considered. Understanding of drug target mechanism can dramatically accelerate early-stage target-based development of novel antimalarials and allows for structural modifications even during late-stage preclinical development. Here, we have provided an overview of three promising antimalarial molecular targets, PfDHFR, PfDHODH and PfA-M1, and their associated inh

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Aksic, Jelena, Marija Gencic, and Niko Radulovic. "Recent updates in the development of mettallocenes with antimalarial activity." Facta universitatis - series: Physics, Chemistry and Technology 18, no. 1 (2020): 1–37. http://dx.doi.org/10.2298/fupct2001001a.

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Great progress in the fight against malaria has been made in the last decade. Nevertheless, the development of resistance to almost all commonly used antimalarial drugs poses a major threat to the sustainability of this progress and highlights the need for the discovery of novel potent and inexpensive antimalarials to stay one step ahead. After the finding of ferrocene-containing analog of chloroquine - ferroquine, that can overcome Plasmodium resistance, a ?big-bang? in the metallocene antimalarials research has occurred. This review describes in detail the most recent advances in this import

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Creek, Darren J., William N. Charman, Francis C. K. Chiu, et al. "Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials." Antimicrobial Agents and Chemotherapy 52, no. 4 (2008): 1291–96. http://dx.doi.org/10.1128/aac.01033-07.

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ABSTRACT The reaction of spiro- and dispiro-1,2,4-trioxolane antimalarials with heme has been investigated to provide further insight into the mechanism of action for this important class of antimalarials. A series of trioxolanes with various antimalarial potencies was found to be unreactive in the presence of Fe(III) hemin, but all were rapidly degraded by reduced Fe(II) heme. The major reaction product from the heme-mediated degradation of biologically active trioxolanes was an alkylated heme adduct resulting from addition of a radical intermediate. Under standardized reaction conditions, a

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MODUPE, IRETIOLA BUILDERS. "The potency of plant antimalarial." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 190–99. https://doi.org/10.5281/zenodo.7602949.

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Malaria has remained a major cause of morbidity and mortality in all parts of the world. It is associated with high economic burden on the nation, high prevalence of mortality in children, pregnant women and non-immune individuals, thus malaria is a global public health problem. This protozoan infection is mainly characterized by fever, pains, loss of appetite and anaemia, researchers had discovered potent antimalarial drugs mainly from plant sources in order to overcome resistance of antimalarials, vectors, inability to develop malarial vaccines and also toxic effects of conventional antimala

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32

Chris-Otubor, Grace Ovayoza, Joseph O. Ehinmidu, and Ikoni Joshua Ogaji. "Incidence of malaria infection and adherence to antimalarial treatment guidelines at Bingham University Teaching Hospital, Jos, Nigeria." Journal of Pharmacy & Bioresources 21, no. 3 (2024): 127–34. http://dx.doi.org/10.4314/jpb.v21i3.4.

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The development of antimalarial resistance has been a foremost barrier to malaria control. The aim of this study was to investigate the incidence of malaria infection and adherence to Antimalarial Treatment Guidelines (ATG) at Bingham University Teaching Hospital (BhUTH), Jos, Nigeria. A descriptive cross-sectional study was carried out to assess malaria infection diagnosis, antimalarials prescription pattern and adherence to the ATG by physicians over a two-year period. The study extracted data from 570 prescriptions of different patients and 227 patient files. The demographics of the patient

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Gomides, Ana, Gilda Ferreira, Adriana Kakehasi, et al. "Impact of Chronic Use of Antimalarials on SARS-CoV-2 Infection in Patients With Immune-Mediated Rheumatic Diseases: Protocol for a Multicentric Observational Cohort Study." JMIR Research Protocols 9, no. 10 (2020): e23532. http://dx.doi.org/10.2196/23532.

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Background COVID-19, caused by the virus SARS-CoV-2, has brought extensive challenges to the scientific community in recent months. Several studies have been undertaken in an attempt to minimize the impact of the disease worldwide. Although new knowledge has been quickly disseminated, including viral mechanisms, pathophysiology, and clinical findings, there is a lack of information on the effective pharmacological management of this disease. In vitro studies have shown some benefits related to the use of antimalarials (chloroquine and hydroxychloroquine) for inhibiting SARS-CoV-2. However, the

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SMITH, PAUL W., THIERRY T. DIAGANA, and BRYAN K. S. YEUNG. "Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages." Parasitology 141, no. 1 (2013): 66–76. http://dx.doi.org/10.1017/s0031182013000747.

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SUMMARYThe number of novel antimalarial candidates entering preclinical development has seen an increase over the last several years. Most of these drug candidates were originally identified as hits coming from screening large chemical libraries specifically targeting the asexual blood stages of Plasmodium falciparum. Indeed, a large proportion of the current antimalarial arsenal has mainly targeted the asexual blood stage which is responsible for clinical symptoms of the disease. However, as part of the eradication agenda and to address resistance, any next-generation antimalarial should have

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&NA;. "Antimalarials." Reactions Weekly &NA;, no. 1363 (2011): 7–8. http://dx.doi.org/10.2165/00128415-201113630-00024.

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&NA;. "Antimalarials." Reactions Weekly &NA;, no. 540 (1995): 5. http://dx.doi.org/10.2165/00128415-199505400-00008.

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&NA;. "Antimalarials." Drugs & Therapy Perspectives 9, no. 6 (1997): 13–16. http://dx.doi.org/10.2165/00042310-199709060-00005.

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Van Beek, Marta J., and Warren W. Piette. "Antimalarials." Dermatologic Therapy 14, no. 2 (2001): 143–53. http://dx.doi.org/10.1046/j.1529-8019.2001.014002143.x.

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Van Beek, Marta J., and Warren W. Piette. "ANTIMALARIALS." Dermatologic Clinics 19, no. 1 (2001): 147–60. http://dx.doi.org/10.1016/s0733-8635(05)70236-9.

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Willoughby, Joanne S., and Neil H. Shear. "Antimalarials." Clinics in Dermatology 7, no. 3 (1989): 60–68. http://dx.doi.org/10.1016/0738-081x(89)90008-4.

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Bhandari, Prasan R., and Apeksha Bhandary. "Variation of cost among anti-malarial drugs available in Indian market." International Journal of Basic & Clinical Pharmacology 8, no. 11 (2019): 2408. http://dx.doi.org/10.18203/2319-2003.ijbcp20194775.

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Background: There are numerous brands of antimalarial existent in the market. Expensive drugs could result in financial drain that causes reduced compliance or even non-compliance. Non-adherence to therapy could consequently cause partial treatment that leads to higher morbidity and in certain cases mortality too. Thus this evaluation was conducted to measure the cost disparity of malaria therapy.Methods: The maximum and minimum price of each brand of the drug in Indian rupee rate was noted by using the latest edition of current index of medical specialities. The cost ratio and the percentage

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Veiga, Maria Isabel, Nuno S. Osório, Pedro Eduardo Ferreira, et al. "Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response." Antimicrobial Agents and Chemotherapy 58, no. 12 (2014): 7390–97. http://dx.doi.org/10.1128/aac.03337-14.

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ABSTRACTPlasmodium falciparumhas the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including theApicomplexaparasites.P. falciparumgenome analysis has revealed two genes coding for the multidrug resistance protein (MRP) type of ABC transporters:Pfmrp1, previously associated with decreased parasite drug susceptibility, and the poorly studiedPfmrp2. The role ofPfmrp2polymorphisms in modulating sensitivity to antimalarial drugs has not been established. We

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Bashige, Chiribagula Valentin, Mushagalusa Kasali Félicien, Ndjolo Philippe Okusa, Amuri Salvius Bakari, and Simbi Jean-Baptiste Lumbu. "Self-medication practices in the management of malaria in the city of Bukavu in Eastern of Democratic Republic of Congo." World Journal of Biology Pharmacy and Health Sciences 3, no. 2 (2020): 029–41. https://doi.org/10.5281/zenodo.4430543.

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Self-medication for malaria management is very common in Democratic Republic of Congo (DRC). This study was conducted to determine the extent, characteristics and factors associated with this practice in medical area in the city of Bukavu. This cross-sectional descriptive study was carried out by direct interview between January and June 2018, in the internal medicine department of the General Referral Hospital (GRH) of Bukavu. Graph Pad software was used to analyze the data collected. Seven hundred eighty-five patients were consulted, among them 57.8% (average age 38.7 ± 8 years; avera

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Taylor, Dennis K., Thomas D. Avery, Ben W. Greatrex, et al. "Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity." Journal of Medicinal Chemistry 47, no. 7 (2004): 1833–39. http://dx.doi.org/10.1021/jm0305319.

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Warhurst, David C. "Antimalarial drugs II: Current antimalarials and new drug development." Trends in Pharmacological Sciences 6 (January 1985): 302–4. http://dx.doi.org/10.1016/0165-6147(85)90140-3.

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Wright, Colin W. "Traditional antimalarials and the development of novel antimalarial drugs." Journal of Ethnopharmacology 100, no. 1-2 (2005): 67–71. http://dx.doi.org/10.1016/j.jep.2005.05.012.

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Wilson, Danny W., Christine Langer, Christopher D. Goodman, Geoffrey I. McFadden, and James G. Beeson. "Defining the Timing of Action of Antimalarial Drugs against Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 57, no. 3 (2013): 1455–67. http://dx.doi.org/10.1128/aac.01881-12.

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ABSTRACTMost current antimalarials for treatment of clinicalPlasmodium falciparummalaria fall into two broad drug families and target the food vacuole of the trophozoite stage. No antimalarials have been shown to target the brief extracellular merozoite form of blood-stage malaria. We studied a panel of 12 drugs, 10 of which have been used extensively clinically, for their invasion, schizont rupture, and growth-inhibitory activity using high-throughput flow cytometry and new approaches for the study of merozoite invasion and early intraerythrocytic development. Not surprisingly, given reported

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McCarthy, Peter J., Bracken F. Roberts, Abigail Carbonell, Jill Roberts, Amy E. Wright, and Debopam Chakrabarti. "Marine Microbiome as a Source of Antimalarials." Tropical Medicine and Infectious Disease 4, no. 3 (2019): 103. http://dx.doi.org/10.3390/tropicalmed4030103.

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It is important to discover novel antimalarial pharmacophores because of the widespread emergence of Plasmodium falciparum isolates resistant to the available drugs. Secondary metabolites derived from microbes associated with marine invertebrates are a valuable resource for the discovery of novel drug leads. However, the potential of marine microbes as a source of antimalarials has not been explored. We investigated the promise of marine microorganisms for the production of antimalarial activities by testing 2365 diverse microbial extracts using phenotypic screening of a multidrug resistant ch

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Rizki, Andita Fitri Mutiara, Wihda Aisarul Azmi, Muhaimin Muhaimin, Melva Louisa, I. Made Artika, and Josephine Elizabeth Siregar. "Antimalarial Activity of Mangrove Plants and Possible Mechanisms of Action: A Scoping Review." Molekul 19, no. 1 (2024): 98. http://dx.doi.org/10.20884/1.jm.2024.19.1.9236.

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Malaria is one of life threatening-infectious diseases with high mortality rate in African regions. Malaria is also one of public health problem in most of Southeast Asia (SEA) regions. This disease is caused by a Apicomplexan parasite; Plasmodium sp., which can be transmitted from humans to humans via Anopheles sp. To date, the need of a new antimalarial drug is still high, due to the rapid increase of drug resistance. Natural-derived drug candidates are still being used by researchers to develop new antimalarials. One of the natural resources which could potentially be a source of antimalari

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Olafson, Katy N., Megan A. Ketchum, Jeffrey D. Rimer, and Peter G. Vekilov. "Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine." Proceedings of the National Academy of Sciences 112, no. 16 (2015): 4946–51. http://dx.doi.org/10.1073/pnas.1501023112.

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Hematin crystallization is the primary mechanism of heme detoxification in malaria parasites and the target of the quinoline class of antimalarials. Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. Among them are the identity of the crystallization medium in vivo, aqueous or organic; the mechanism of crystallization, classical or nonclassical; and whether quinoline antimalarials inhibit crystallization by sequestering hematin in the solution, or by blocking surface sites crucial for growth. Here we use time-resolved in s

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