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Journal articles on the topic 'Antimetastatic activity'

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1

Thejass, P., and Girija Kuttan. "Antimetastatic activity of Sulforaphane." Life Sciences 78, no. 26 (2006): 3043–50. http://dx.doi.org/10.1016/j.lfs.2005.12.038.

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Wahyuni, W., Ajeng Diantini, Mohammad Ghozali, et al. "Cytotoxic and Antimigration Activity of Etlingera alba (A.D.) Poulsen Rhizome." Advances in Pharmacological and Pharmaceutical Sciences 2021 (December 28, 2021): 1–10. http://dx.doi.org/10.1155/2021/6597402.

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Etlingera alba is one of the Etlingera plants that might have anticancer activity. This study aims to investigate the cytotoxic and antimetastatic activity of E. alba rhizome fractions and migration cell assay against MDA-MB-231 cell lines, which are used for triple-negative breast cancer (TNBC) treatment assay. The cytotoxic activity was assayed using CCK-8 assay, while the antimetastatic was assayed using migration cell assay for the fractions A–F. They were followed by LCMS/MS profiling to determine the chemical contents in the most active fraction. According to results obtained, fraction B
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3

Urazova, L., and A. Gromova. "Antimetastatic activity of viral oncolysates." European Journal of Cancer 33 (September 1997): S90. http://dx.doi.org/10.1016/s0959-8049(97)84822-8.

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4

Zhurikov, R. V., L. P. Kovalenko, S. V. Nikitin, and A. D. Durnev. "EFFECTS OF 5-HYDROXYPYRIMIDINE DERIVATIVE ON GROWTH AND METASTASIS OF MELANOMA B16 IN C57BL/6 MICE." Russian Journal of Biotherapy 20, no. 3 (2021): 66–72. http://dx.doi.org/10.17650/1726-9784-2021-20-3-66-72.

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Introduction. Suppression of activation of an alternative immune response is promising approach of tumor immunotherapy. In this study we evaluated antitumor and antimetastatic activity of SNK-411.Objective. Evaluation of antitumor and antimetastatic activity of 5-hydroxypyrimidine derivative SNK-411 in mouse melanoma B16 model.Materials and methods. Antitumor and antimetastatic activity of the SNK-411 were studied in tests on male C57BL/6 mice using the B16-F10 melanoma model. SNK-411 was injected intraperitoneally at doses of 10 and 25 mg/kg from day 2 to day 15 of melanoma development. Doxor
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5

Kuttan, G., L. G. Menon, S. Antony, and R. Kuttan. "Anticarcinogenic and antimetastatic activity of Iscador." Anti-Cancer Drugs 8, Supplement 1 (1997): S15—S16. http://dx.doi.org/10.1097/00001813-199704001-00004.

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6

Steinmann, Patrick, Denise K. Walters, Matthias J. E. Arlt, et al. "Antimetastatic activity of honokiol in osteosarcoma." Cancer 118, no. 8 (2011): 2117–27. http://dx.doi.org/10.1002/cncr.26434.

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7

Blinova, Ekaterina V., Anna V. Epishkina, Oksana M. Tumutolova, et al. "Antitumor activity of the novel pyridine derivative." Research Results in Pharmacology 8, no. 3 (2022): 81–86. http://dx.doi.org/10.3897/rrpharmacology.8.89997.

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Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine derivative LHT-17-19 in cell culture and on experimental models of lung cancer in mice. Materials and methods: The study was performed on male and female ICR(CD-1), male BALB/c, male BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) was studied as water-soluble pharmaceutical substance. Acute toxicity was evaluated in groups of 5 animals, and the results were analyzed by Finney. Antitumor and antimetastatic activity was studied in syngeneic and xenograft models of lung cancer in mice
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8

Blinova, Ekaterina V., Anna V. Epishkina, Oksana M. Tumutolova, et al. "Antitumor activity of the novel pyridine derivative." Research Results in Pharmacology 8, no. (3) (2022): 81–86. https://doi.org/10.3897/rrpharmacology.8.89997.

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Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine derivative LHT-17-19 in cell culture and on experimental models of lung cancer in mice. Materials and methods: The study was performed on male and female ICR(CD-1), male BALB/c, male BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) was studied as water-soluble pharmaceutical substance. Acute toxicity was evaluated in groups of 5 animals, and the results were analyzed by Finney. Antitumor and antimetastatic activity was studied in syngeneic and xenograft models of lung cancer in mice
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9

Lo, Chia-Hui, Shan-Chih Lee, Pin-Yi Wu, et al. "Antitumor and Antimetastatic Activity of IL-23." Journal of Immunology 171, no. 2 (2003): 600–607. http://dx.doi.org/10.4049/jimmunol.171.2.600.

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10

Kundu, Namita, Patricia Campbell, Brian Hampton, et al. "Antimetastatic activity isolated from Colocasia esculenta (taro)." Anti-Cancer Drugs 23, no. 2 (2012): 200–211. http://dx.doi.org/10.1097/cad.0b013e32834b85e8.

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11

Ohno, Takamasa, Makoto Inoue, Yukio Ogihara, and Iclal Saracoglu. "Antimetastatic Activity of Acteoside, a Phenylethanoid Glycoside." Biological & Pharmaceutical Bulletin 25, no. 5 (2002): 666–68. http://dx.doi.org/10.1248/bpb.25.666.

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12

Nanni, Patrizia, Giordano Nicoletti, Arianna Palladini, et al. "Antimetastatic Activity of a Preventive Cancer Vaccine." Cancer Research 67, no. 22 (2007): 11037–44. http://dx.doi.org/10.1158/0008-5472.can-07-2499.

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13

Roche-Nagle, G., E. M. Connolly, M. Eng, D. J. Bouchier-Hayes, and J. H. Harmey. "Antimetastatic activity of a cyclooxygenase-2 inhibitor." British Journal of Cancer 91, no. 2 (2004): 359–65. http://dx.doi.org/10.1038/sj.bjc.6601967.

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14

Scholar, E. M., L. Violi, and T. D. Hexum. "The antimetastatic activity of enkephalin-like peptides." Cancer Letters 35, no. 2 (1987): 133–38. http://dx.doi.org/10.1016/0304-3835(87)90036-x.

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15

Baloglu, Murat, Canan Vejselova Sezer, Hüseyin Izgördü, Ibrahim Yilmaz, and Hatice Mehtap Kutlu. "Could Fingolimod Combined with Bevacizumab Be a New Hope in Glioblastoma Treatment?" Current Issues in Molecular Biology 47, no. 6 (2025): 394. https://doi.org/10.3390/cimb47060394.

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Glioblastoma, classified as a grade IV astrocytoma, is an aggressive and malignant primary brain tumor with no known cure. Despite the implementation of standard medical and surgical treatment protocols, the disease often progresses with unsatisfactory outcomes. This study aimed to evaluate the cytotoxic, proapoptotic, and antimetastatic effects of anti-angiogenic monoclonal antibody bevacizumab combined with the sphingosine-1-phosphate receptor modulator fingolimod on rat glioma C6 cells. The cytotoxicity of bevacizumab and fingolimod was evaluated using the MTT assay. Proapoptotic activity w
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16

Arsenyan, Pavel, Jelena Vasiljeva, Ilona Domracheva, Iveta Kanepe-Lapsa, and Anita Gulbe. "Selenopheno[2,3-f]coumarins: novel scaffolds with antimetastatic activity against melanoma and breast cancer." New Journal of Chemistry 43, no. 30 (2019): 11851–64. http://dx.doi.org/10.1039/c9nj01682a.

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17

Xin, Hong, Andreas Herrmann, Karen Reckamp, et al. "Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480." Cancer Research 71, no. 21 (2011): 6601–10. http://dx.doi.org/10.1158/0008-5472.can-11-1217.

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18

Gol’dberg, E. D., E. N. Amosova, E. P. Zueva, T. G. Razina, and S. G. Krylova. "Antimetastatic activity of sea buckthorn (Hippophae rhamnoides) extracts." Bulletin of Experimental Biology and Medicine 143, S1 (2007): 50–54. http://dx.doi.org/10.1007/s10517-007-0080-4.

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19

Gu, Liwei, Xiaodong Li, Qingsen Ran, Chen Kang, Canghai Lee, and Jianying Shen. "Antimetastatic activity of novel ruthenium ( III ) pyridine complexes." Cancer Medicine 5, no. 10 (2016): 2850–60. http://dx.doi.org/10.1002/cam4.826.

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20

Tian, Zhenzhen, Yuliang Yang, Lihua Guo, Genshen Zhong, Juanjuan Li, and Zhe Liu. "Dual-functional cyclometalated iridium imine NHC complexes: highly potent anticancer and antimetastatic agents." Inorganic Chemistry Frontiers 5, no. 12 (2018): 3106–12. http://dx.doi.org/10.1039/c8qi00920a.

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21

Gurgul, Ilona, Olga Mazuryk, Michał Łomzik, Philippe C. Gros, Dorota Rutkowska-Zbik, and Małgorzata Brindell. "Unexplored features of Ru(ii) polypyridyl complexes – towards combined cytotoxic and antimetastatic activity." Metallomics 12, no. 5 (2020): 784–93. http://dx.doi.org/10.1039/d0mt00019a.

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22

Somasekharan, Syam Prakash, Amal El-Naggar, Poul H. Sorensen, Yuzhuo Wang, and Hongwei Cheng. "An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9730654.

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Research on marine natural products as potential anticancer agents is still limited. In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung, prostate, stomach, breast, and pancreatic cancers, as well as an osteosarcoma.In vitro, the microalgal extract exhibited marked anticolony forming activity. In addition, it was more toxic, as indicated by increased apoptosis, to nonadherent cells (grown in suspension) than to adherent cells.In vivo, an antimetastatic ef
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23

Ravera, Mauro, Elisabetta Gabano, Ilaria Zanellato, et al. "Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity." Dalton Transactions 50, no. 9 (2021): 3161–77. http://dx.doi.org/10.1039/d0dt04051g.

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24

Dodokhova, Margarita A., Andrey V. Safronenko, Inga M. Kotieva, Margarita S. Alkhuseyn-Kulyaginova, Dmitry B. Shpakovsky, and Elena R. Milaeva. "Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes." Research Results in Pharmacology 8, no. (1) (2022): 85–93. https://doi.org/10.3897/rrpharmacology.8.76363.

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Introduction: In modern medical chemistry, much attention is paid to the search for new antimetastatic agents based on metal compounds. Organotin compounds promise to be good candidates as the treatment of malignant neoplasms. In order to reduce a possible nonspecific toxic effect of tin compounds and to expand the intended therapeutic use, the paper presents hybrid tin (IV) complexes with Sn-S bond containing a fragment of 2,6-di-tert-butylphenol. The aim of the study was to evaluate the antitumor and antimetastatic effects of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3)
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25

Guedes, Adriana Pereira Mundim, Francyelli Mello-Andrade, Wanessa Carvalho Pires, et al. "Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets." Metallomics 12, no. 4 (2020): 547–61. http://dx.doi.org/10.1039/c9mt00272c.

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26

Tayeh, Malatee, and Ramida Watanapokasin. "Antimetastatic Potential of Rhodomyrtone on Human Chondrosarcoma SW1353 Cells." Evidence-Based Complementary and Alternative Medicine 2020 (July 27, 2020): 1–12. http://dx.doi.org/10.1155/2020/8180261.

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Chondrosarcoma is primary bone cancer, with the forceful capacity to cause local invasion and distant metastasis, and has a poor prognosis. Cancer metastasis is a complication of most cancers; it is one of the leading causes of cancer-related death. Rhodomyrtone is a pure compound that has been shown to induce apoptosis and antimetastasis in skin cancer. However, the inhibitory effect of rhodomyrtone on human chondrosarcoma cell metastasis is largely unknown. Effect of rhodomyrtone on cell viability in SW1353 cell was determined by MTT assay. Antimigration, anti-invasion, and antiadhesion were
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27

Kazhemekaite, M., V. Shimkyavichene, and Z. Stumbryavichyute. "Synthesis and antimetastatic activity of 3,3-dimethyltriazene aryl derivatives." Pharmaceutical Chemistry Journal 30, no. 1 (1996): 19–21. http://dx.doi.org/10.1007/bf02218920.

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28

Bocharova, O. A., R. V. Karpova, V. A. Golubeva, T. G. Filippova, N. N. Kasatkina, and A. Yu Baryshnikov. "In vivo antimetastatic and immunomodulating activity of phytomix-40." Bulletin of Experimental Biology and Medicine 128, no. 4 (1999): 1005–8. http://dx.doi.org/10.1007/bf02433190.

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29

Krüger, Achim, Matthias J. E. Arlt, Michael Gerg, et al. "Antimetastatic Activity of a Novel Mechanism-Based Gelatinase Inhibitor." Cancer Research 65, no. 9 (2005): 3523–26. http://dx.doi.org/10.1158/0008-5472.can-04-3570.

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30

Carminati, Laura, Denise Pinessi, Patrizia Borsotti, et al. "Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma." Carcinogenesis 40, no. 2 (2018): 303–12. http://dx.doi.org/10.1093/carcin/bgy177.

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31

Strzadala, Leon, Ianusz Rak, Ewa Ziolo, Maria Paprocka, Czeslaw Radzikowski, and Willem Den Otter. "Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity." Cancer Immunology, Immunotherapy 30, no. 1 (1989): 51–56. http://dx.doi.org/10.1007/bf01665030.

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32

Yang, Xiao-Chun, Chong-Xing Tu, Pei-Hua Luo, et al. "Antimetastatic activity of MONCPT in preclinical melanoma mice model." Investigational New Drugs 28, no. 6 (2009): 800–811. http://dx.doi.org/10.1007/s10637-009-9323-8.

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33

Dodokhova, Margarita A., Andrey V. Safronenko, Inga M. Kotieva, Margarita S. Alkhuseyn-Kulyaginova, Dmitry B. Shpakovsky, and Elena R. Milaeva. "Evaluation of the pharmacological activity of hybrid organotin compounds in a B16 melanoma model in the classical and metronomic administration modes." Research Results in Pharmacology 8, no. 1 (2022): 85–93. http://dx.doi.org/10.3897/rrpharmacology.8.76363.

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Introduction: In modern medical chemistry, much attention is paid to the search for new antimetastatic agents based on metal compounds. Organotin compounds promise to be good candidates as the treatment of malignant neoplasms. In order to reduce a possible nonspecific toxic effect of tin compounds and to expand the intended therapeutic use, the paper presents hybrid tin (IV) complexes with Sn-S bond containing a fragment of 2,6-di-tert-butylphenol. The aim of the study was to evaluate the antitumor and antimetastatic effects of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3)
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34

&NA;. "TIMP: in vivo antimetastatic activity is related to in vitro antimetalloproteinase activity." Inpharma Weekly &NA;, no. 744 (1990): 6. http://dx.doi.org/10.2165/00128413-199007440-00014.

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35

Lovison, Denise, Lorenzo Allegri, Federica Baldan, et al. "Cationic carboxylate and thioacetate ruthenium(ii) complexes: synthesis and cytotoxic activity against anaplastic thyroid cancer cells." Dalton Transactions 49, no. 24 (2020): 8375–88. http://dx.doi.org/10.1039/d0dt01390k.

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High cytotoxic and antimetastatic activities against anaplastic thyroid cancer are displayed by cationic complexes [RuX(CO)(dppb)(phen)]Y (X = Y = OAc, OPiv, SAc, and NCS; X = Cl and Y = PF<sub>6</sub>).
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36

Kyaw, Kay Zin, Jiyoon Park, Seung Ho Oh, et al. "Antimetastatic Activity of Apoptolidin A by Upregulation of N-Myc Downstream-Regulated Gene 1 Expression in Human Colorectal Cancer Cells." Pharmaceuticals 16, no. 4 (2023): 491. http://dx.doi.org/10.3390/ph16040491.

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Colorectal cancer (CRC) is one of the most prevalent tumors with high metastatic potential; consequently, finding new drug candidates that suppress tumor metastasis is essential. Apoptolidin A is a macrocyclic lactone produced by Amycolatopsis sp. DW02G. It exhibits significant cytotoxicity against several cancer cell lines, but its effects on CRC cells remain unknown. Therefore, the present study investigated the antiproliferative and antimetastatic activities of apoptolidin A and its underlying molecular mechanisms in CRC cells. Apoptolidin A effectively inhibited CRC cell growth and colony
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37

Shu, Liwei, Lulu Ren, Yuchen Wang, et al. "Niacin-ligated platinum(iv)–ruthenium(ii) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo." Chemical Communications 56, no. 20 (2020): 3069–72. http://dx.doi.org/10.1039/c9cc09016a.

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The chimeric Pt(iv)–Ru(ii) complex was designed to simultaneously release cytotoxic cisplatin and an antimetastatic Ru(ii)–arene compound, thereby producing potent anticancer activity with high drug tolerability in animals.
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38

Liu, Xin-Yao, Yu-Miao Wang, Xiang-Yu Zhang та ін. "Alkaloid Derivative (Z)-3β-Ethylamino-Pregn-17(20)-en Inhibits Triple-Negative Breast Cancer Metastasis and Angiogenesis by Targeting HSP90α". Molecules 27, № 20 (2022): 7132. http://dx.doi.org/10.3390/molecules27207132.

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Metastasis is an important cause of cancer-related death. Previous studies in our laboratory found that pregnane alkaloids from Pachysandra terminalis had antimetastatic activity against breast cancer cells. In the current study, we demonstrated that treatment with one of the alkaloid derivatives, (Z)-3β-ethylamino-pregn-17(20)-en (1), led to the downregulation of the HIF-1α/VEGF/VEGFR2 pathway, suppressed the phosphorylation of downstream molecules Akt, mTOR, FAK, and inhibited breast cancer metastasis and angiogenesis both in vitro and in vivo. Furthermore, the antimetastasis and antiangioge
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39

Manaharan, Thamilvaani, Ramaraj Thirugnanasampandan, Rajarajeswaran Jayakumar, Gunasekar Ramya, Gogul Ramnath, and M. S. Kanthimathi. "Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from EdibleOcimum sanctumLeaves." Scientific World Journal 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/239508.

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Antimetastatic and anti-inflammatory activities ofOcimum sanctumessential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant (P*&lt;0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, ad
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40

Pyaskovskaya, O. N., D. L. Kolesnik, A. G. Fedorchuk, I. V. Prochorova, and G. I. Solyanik. "2-DEOXY-D-GLUCOSE ENHANCES DICHLOROACETATE ANTITUMOR ACTION AGAINST LEWIS LUNG CARCINOMA." Experimental Oncology 38, no. 3 (2016): 176–80. http://dx.doi.org/10.31768/2312-8852.2016.38(3):176-180.

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Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. Aim: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC). Materials and Methods: As experimental tumor model, LLC/R9 varian
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41

Smyth, Mark J., Nadine Y. Crowe, Daniel G. Pellicci та ін. "Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide". Blood 99, № 4 (2002): 1259–66. http://dx.doi.org/10.1182/blood.v99.4.1259.

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The antimetastatic effect of the CD1d-binding glycolipid, α-galactosylceramide (α-GalCer), is mediated by NK1.1+T (NKT) cells; however, the mechanisms behind this process are poorly defined. Although it has been shown to involve NK cells and interferon-γ (IFN-γ) production, the way these factors collaborate to mediate effective tumor rejection and the importance of other factors characteristic of NKT cell and NK cell activation are unknown. Using gene-targeted mice and antibody treatments, the critical need for interleukin 12 (IL-12), IFN-γ, and NK cells has been shown in the antimetastatic ac
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42

Brunda, M. J., L. Luistro, R. R. Warrier, et al. "Antitumor and antimetastatic activity of interleukin 12 against murine tumors." Journal of Experimental Medicine 178, no. 4 (1993): 1223–30. http://dx.doi.org/10.1084/jem.178.4.1223.

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It has recently been demonstrated that in vivo administration of murine interleukin 12 (IL-12) to mice results in augmentation of cytotoxic natural killer (NK)/lymphocyte-activated killer cell activity, enhancement of cytolytic T cell generation, and induction of interferon gamma secretion. In this study, the in vivo activity of murine IL-12 against a number of murine tumors has been evaluated. Experimental pulmonary metastases or subcutaneous growth of the B16F10 melanoma were markedly reduced in mice treated intraperitoneally with IL-12, resulting in an increase in survival time. The therape
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43

Giraldi, T., G. Sava, L. Perissin, S. Zorzet, P. Piccini, and V. Rapozzi. "Antimetastatic activity of the prostacyclin analog iloprost in the mouse." Pharmacological Research Communications 20 (September 1988): 182. http://dx.doi.org/10.1016/s0031-6989(88)80312-6.

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44

Kundu, N., T. L. Beaty, E. C. Borden, and A. M. Fulton. "Antitumor and Antimetastatic Activity of Interleukin-10 in Mammary Cancer." Journal of Immunotherapy 18, no. 2 (1995): 133. http://dx.doi.org/10.1097/00002371-199508000-00030.

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45

Kimoto, Masashi, Koichi Ando, Sachiko Koike, et al. "Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide." Clinical & Experimental Metastasis 11, no. 3 (1993): 285–92. http://dx.doi.org/10.1007/bf00121171.

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46

Nikitin, S. V., L. P. Kovalenko, A. G. Rebeko, R. V. Zhurikov, E. A. Ivanova, and A. D. Durnev. "Synthesis and Antitumor and Antimetastatic Activity of 5-hydroxypyrimidine Derivatives." Pharmaceutical Chemistry Journal 53, no. 8 (2019): 697–700. http://dx.doi.org/10.1007/s11094-019-02065-1.

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47

Blank, Michael, Gad Lavie, Mathilda Mandel, et al. "Antimetastatic activity of the photodynamic agent hypericin in the dark." International Journal of Cancer 111, no. 4 (2004): 596–603. http://dx.doi.org/10.1002/ijc.20285.

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48

Jibul, Tatsuo, Sachiko Koike, Koichi Ando, Tsuneya Matsumoto, Masashi Kimoto, and Shiro Kanegasaki. "Antimetastatic activity of lipopolysaccharide against a NK-resistant murine fibrosarcoma." Clinical & Experimental Metastasis 11, no. 4 (1993): 306–12. http://dx.doi.org/10.1007/bf00058050.

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49

Ahn, Ji-Hye, Dae Sik Jang, and Jung-Hye Choi. "Lancemaside A Isolated from the Root of Codonopsis lanceolata Inhibits Ovarian Cancer Cell Invasion via the Reactive Oxygen Species (ROS)-Mediated p38 Pathway." American Journal of Chinese Medicine 48, no. 04 (2020): 1021–34. http://dx.doi.org/10.1142/s0192415x20500494.

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Codonopsis lanceolata roots have been widely used in Korean cuisine and traditional medicine. This study aimed to investigate the antimetastatic effects of lancemaside A, a major triterpenoid saponin, isolated from the roots of C. lanceolata, in human ovarian cancer cells. Lancemaside A significantly suppressed the migration and invasion and the expression of matrix metalloproteinases (MMPs)-2 and -9 in ovarian cancer A2780 and SKOV3 cells. Treatment with lancemaside A generated reactive oxygen species (ROS) in ovarian cancer cells. However, treatment with anti-oxidant N-acetyl-L-cysteine (NAC
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Coluccia, M., G. Sava, G. Salerno, et al. "Efficacy of 5-FU Combined to Na[trans-RuCl4(DMSO)Im] , A Novel Selective Antimetastatic Agent, on the Survival Time of Mice With P388 Leukemia, P388/DDP subline and MCa Mammary Carcinoma." Metal-Based Drugs 2, no. 4 (1995): 195–99. http://dx.doi.org/10.1155/mbd.1995.195.

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Abstract:
The combinational treatment between the selective antimetastatic agent, sodium-trans-rutheniumtetrachloridedimethylsulfoxideimidazole, Na[trans-RuCl4(DMSO)Im], and the cytotoxic drug 5-fluorouracil (5-FU) on primary tumor growth and on the survival time of experimental tumors results in an effect significantly greater than that of each single agent used alone either with the solid metastasizing MCa mammary carcinoma of the CBA mouse or with the lymphocytic leukemia P388 and its platinum resistant P388/DDP subline. Thus the inorganic compound Na[trans-RuCl4(DMSO)Im], known for its potent and se
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