Academic literature on the topic 'Antimicrobial activity of cinnoline derivatives'

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Journal articles on the topic "Antimicrobial activity of cinnoline derivatives"

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Gautam, Nidhi, and O. P. Chourasia. "ChemInform Abstract: Synthesis, Antimicrobial and Insecticidal Activity of Some New Cinnoline Based Chalcones and Cinnoline Based Pyrazoline Derivatives." ChemInform 41, no. 44 (2010): no. http://dx.doi.org/10.1002/chin.201044161.

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ABBADY, M. S., SH M. RADWAN, and E. A. BAKHITE. "ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Cinnoline Derivatives Containing Sulfonamido Group." ChemInform 25, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199418158.

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R., GOPIKUMAR MENON, and PURUSHOTHAMAN E. "Synthesis of Biologically Active 5-( 4-Hydroxycinnolin-3-yl)tetrazoles and 2-Methyl-5-( 4-acetoxycinnolin-3-yl)-1 ,3,4-oxadiazoles." Journal of Indian Chemical Society Vol. 74, Feb 1997 (1997): 123–24. https://doi.org/10.5281/zenodo.5875232.

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Department of Chemistry, University of Calicut, Calicut-673 635 <em>Manuscript received 29 November 1994, revised 5 July 1995. accepted 14 August 1995</em> A series of 5-(4-hydroxycinnolin-3-yl)tetrazoles and 2-methyl-5-(4-acetoxycinnolin-3-yl)-1,3.4-oxadiazo)es have been synthesised. The compounds exhibited moderate antimicrobial activity. None of the tetrazoles showed any antihistaminic activity.
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M., R. Patel, D. Akbari J., H. Purohit D., and S. Joshi H. "Synthesis and evaluation of pharmacological activity of some new aminopyrimidine and thiopyrimidine derivatives." Journal of Indian Chemical Society Vol. 84, Nov 2007 (2007): 1169–73. https://doi.org/10.5281/zenodo.5824805.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India <em>E-mail </em>: drhsjoshi@yahoo.com <em>Manuscript received 15 January 2007, revised 6 June 2007, accepted 17 August 2007</em> Various 3-(2-amino-6-arylpyrimidin-4-yl)-6-chlorocinnolin-4(3<em>H)</em>-one (2a-j) and 6-chloro-3-(6-aryl-2-mercapto3,4-dihydropyrimidin-4-yl)cinnolin-4(3<em>H</em>)-one (3a-j) were synthesized by the reaction of 6-chloro-3-[(2<em>E</em>)-3-arylprop-2-enoyl]- cinnolin-4(3<em>H</em>)-ones (1a-j) with guanidine hydrochloride and thiourea respectively. All newly synthesized compounds were te
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Lewgowd, Wieslawa, and Andrzej Stanczak. "Cinnoline Derivatives with Biological Activity." Archiv der Pharmazie 340, no. 2 (2007): 65–80. http://dx.doi.org/10.1002/ardp.200500194.

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Dr. M.Rajasekaran, Dr M. Rajasekaran, H. B. Nihal Furkhan H.B.Nihal Furkhan, R. Nishanth R.Nishanth, N. Panneerselvam N.Panneerselvam, B. S. Nithishkumar B.S.Nithishkumar, and M. Pandiyan M.Pandiyan. "Synthesis and Docking Studies of Cinnoline Derivatives for Enhanced Anti-Bacterial Activity." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1797–815. https://doi.org/10.35629/4494-100217971815.

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This study involves the synthesis and evaluation of a series of cinnoline derivatives for their biological activities. The compounds were synthesized through a multi-step process, including the preparation of benzene diazonium chloride, formation of phenyl hydrazoneacetylacetone, synthesis of 4-methyl-3-acetyl cinnoline, and subsequent reactions with various amines. These compounds were characterized using Thin Layer Chromatography (TLC), melting point determination, solubility tests, and advanced spectroscopic techniques, including Infrared (IR) and Proton Nuclear Magnetic Resonance (1HNMR) s
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Szumilak, Marta. "Polyamine derivatives as potential bisintercalators with antiproliferative activity." Postępy Polskiej Medycyny i Farmacji 4 (June 24, 2016): 9–15. http://dx.doi.org/10.5604/01.3001.0011.6389.

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Bisntercalators are very interesting group of compounds with potential antitumor activity. They interact reversibly with DNA double helix. These agents share common structural features such as the presence of two, planar, polycyclic aromatic or heteroaromatic systems separated by a spacer chain which must be long enough to enable double intercalation between base pairs. The unique chemical structure of these compounds provides numerous modifications within their structure resulting either in higher activity or increased selectivity toward tumor cells. Within the framework of the project, new p
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Prashanthi Evangeline M, Prem Kumar P, and Bala Murugan K. "Cinnoline Derivatives as Antibacterial Agent and Antimycobacterial Agent: Synthesis, Microbial Evaluation and Molecular Docking Study." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6675–84. http://dx.doi.org/10.26452/ijrps.v11i4.3588.

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Fourteen Novel cinnoline library compounds were designed, synthesized through a facile approach, and allowed for screening for anti-bacterial activity and anti-tubercular activity. The titled compounds were entirely synthesized by replacing alkyl groups, sulphonyl, halo groups in the 6th &amp; 7th position of cinnoline moiety. The enlightenment of structure was done by FTIR HNMR along with elemental analysis and further docked for Structural activity. The newly synthesized Cinnoline Compounds were examined for their in vitro drug-sensitive M tuberculosis H37Hv strain. All the compounds have sh
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Lettreuch, H., M. Khodja, and H. Boutoumi. "New Synthetic Route to Cinnoline Derivatives and Their Microbiological Activity." Russian Journal of Organic Chemistry 56, no. 12 (2020): 2188–93. http://dx.doi.org/10.1134/s1070428020120222.

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Kandeel, Manal M., Aliaa M. Kamal, Bassem H. Naguib, and Marwa S. A. Hassan. "Design, Synthesis, Cytotoxic Activity and Apoptosis-inducing Action of Novel Cinnoline Derivatives as Anticancer Agents." Anti-Cancer Agents in Medicinal Chemistry 18, no. 8 (2018): 1208–17. http://dx.doi.org/10.2174/1871520618666180220121319.

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Aims: Tyrosine kinases and topoisomerase I are common target enzymes for the majority of the anticancer agents. In contrast to quinazolines and quinolines, kinase inhibitors and topoisomerase inhibitors incorporating cinnoline scaffold are relatively infrequent. Thus the aim of this work was to replace the former scaffolds with the latter one. Eighteen novel cinnoline derivatives were designed, synthesized and characterized using both microanalytical and spectral data. Methods: The cytotoxic activity of the new compounds was screened in vitro against both human breast cancer cells and normal b
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Dissertations / Theses on the topic "Antimicrobial activity of cinnoline derivatives"

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Nascimento, PatrÃcia Georgina Garcia do. "Obtaining of derivatives lithocholic acid and antimicrobial activity." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16720.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>This paper describes obtaining eight lithocholic acid derivatives, as well as inhibitory activity. Interest in the use of lithocholic acid as starting material for the preparation of derivatives arose because of it being widely studied in order to discover new biological activities and such studies have shown good results. In this work it was used for the synthesis of a series of derivatives with modifications at the C-3 and/or C-24 of the steroid skeleton. The series was prepared using simple chemical and showed good yields. Aiming
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Chakraborty, Madhumita. "Studies on the antimicrobial activity of available triterpenoids and its derivatives from some medicinal plants." Thesis, University of North Bengal, 2012. http://hdl.handle.net/123456789/1443.

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Alasmary, Fatmah A. S. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents. An investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at pos
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Alasmary, Fatmah Ali Saeed. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents : an investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at positions
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Sobola, Abdullahi Owolabi. "Synthesis, characterization and antimicrobial activity of copper (II) complexes of some hydroxybenzaldimines and their derivatives." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1016258.

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This study focuses on the antimicrobial activity of Cu(II) complexes of some orthohydroxybenzaldimines and its derivatives. Four different categories of Schiff base ligands were prepared by condensing salicylaldehyde, o-vanillin, p-vanillin and vanillin with p- and osubstituted anilines; 1-aminonaphthalene; 2- and 3-aminopyridine; 2- and 3- aminomethylpyridine as well as 2-aminobenzimidazole. The last category was prepared from ophenylenediamine and o-vanillin. The Schiff base ligands have been characterized by a combination of elemental analysis and spectral (¹H- and ¹³C-NMR, UV/Visible, infr
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Gaivelytė, Kristina. "5-nitrofuraldehido darinių antimikrobinio aktyvumo tyrimas, toksiškumo, farmakokinetikos ir struktūros aktyvumo ryšio įvertinimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100621_093138-22354.

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5-nitrofuraldehido darinių antimikrobinio aktyvumo tyrimas, toksiškumo, farmakokinetinių savybių ir struktūros aktyvumo ryšio įvertinimas. K. Gaivelytės magistro baigiamasis darbas. Moksliniai vadovai: dr. V. Petrikaitė, dr. J. Šarlauskas, prof. habil. dr. A. Pavilonis; Kauno medicinos universiteto, Farmacijos fakulteto, Vaistų chemijos katedra. Kaunas, 2010. Darbo tikslas – įvertinti 5-nitrofuraldehido darinių struktūros įtaką jų antimikrobiniam aktyvumui ir parinkti perspektyviausius antimikrobinius junginius tolimesniems tyrimams. Tyrimo metodai. Junginių antimikrobinio aktyvumo prognozė at
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Srđan, Bjedov. "Sinteza i biološka ispitivanja novih derivata žučnih kiselina." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104087&source=NDLTD&language=en.

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U disertaciji je ostvarena sineza amida i oksazolina žučnih kiselina, kao i njihovih alkil i alkilidenskih derivata polazeći od holne kiseline. Ipitano je pona&scaron;anje različitih okso derivata žučnih kiselina u uslovima Grignard-ove i Wittig-ove reakcije. Ispitana je biolo&scaron;ka aktivnost odabranih sintetizovanih jedinjenja<br>Synhesis of bile acid amide and oxazoline derivatives, and their alkyl and alkylidene derivatives was accomplished starting from cholic acid. Also, chemical behavior of different bile acid oxo derivatives in Grignard and Wittig reaction was investigated. Biologic
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Milica, Karadžić. "Хроматографска, микробиолошка и in silico анализа стероидних једињења од потенцијалног биомедицинског значаја". Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2017. http://www.cris.uns.ac.rs/record.jsf?recordId=104606&source=NDLTD&language=en.

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Испитивано је хроматографско понашање (хроматографска липофилност) 29 стероидних једињења (триазола и тетразола, толуенсулфонилхидразида, диона, нитрила и динитрила) од потенцијалног биомедицинског значаја, испитивано је помоћу течне хроматографије високих перформанси на обрнутим фазама, применом две стационарне и две мобилне фазе. Липофилност, изражена преко ретенционог параметра logk, моделована је QSRR приступом. Формирани линеарни и нелинеарни модели омогућили су испитивање односа између ретенционих параметара и in silico молекулских дескриптора, који су израчунати на основу структуре испи
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Alasmary, Fatmah A. S., Anna M. Snelling, M. E. Zain, A. M. Alafeefy, A. S. Awaad, and Nazira Karodia. "Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents." 2015. http://hdl.handle.net/10454/9303.

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No<br>A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxac
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Ke, Fang-Ying, and 柯方盈. "Studies on the Syntheses of Pyrazoline、Thiazoline Derivatives and their Antimicrobial、Antioxidative Activity." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/06836031465387714444.

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碩士<br>南台科技大學<br>化學工程系<br>91<br>Many heterocyclic compounds have been known for special physiological activity. Therefore, sydnonyl-substituted pyrazolines, thiazolines and thiazolidines were synthesized in this study. The text is divided into two parts: In the first part, the sydnonyl-substituted pyrazoline derivatives were prepared successfully through the reactions of sydnonyl-substituted α, β-unsaturated ketones and hydrazine hydrate. The new series of sydnonyl-substituted pyrazolines were evaluated for their antimicrobial activity. The results indicated that the antifungal activity of thes
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Books on the topic "Antimicrobial activity of cinnoline derivatives"

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Jenssen, Havard. Antimicrobial activity of lactoferrin and lactoferrin derived peptides. Nova Science, 2009.

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Kaur, Ms Rajwant. Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives. Independently Published, 2018.

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Kozłowska, Joanna, and Anna Duda-Madej, eds. Antimicrobial Activity of Different Plant Extracts, Plant-Derived Compounds and Synthetic Derivatives of Natural Compounds on Pathogenic Microorganisms. MDPI, 2024. http://dx.doi.org/10.3390/books978-3-7258-1423-7.

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Book chapters on the topic "Antimicrobial activity of cinnoline derivatives"

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Yalpani, Manssur, Fran Johnson, and Larry E. Robinson. "Antimicrobial Activity of Some Chitosan Derivatives." In Advances in Chitin and Chitosan. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-5942-5_61.

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Feio, S. S., A. M. Silva, L. Reis, B. Gigante, J. C. Roseiro, and M. J. Marcelo-Curto. "Antimicrobial Activity of Dehydroabietic Acid Derivatives (II)." In Natural Products in the New Millennium: Prospects and Industrial Application. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-015-9876-7_25.

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van Doorne, H., E. H. Bosch, and C. F. Lerk. "Interactions between Cyclodextrins and Some Antimycotic Imidazole Derivatives: Studies on Solubility and Antimicrobial Activity." In Proceedings of the Fourth International Symposium on Cyclodextrins. Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-2637-0_42.

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Hoogkamp-Korstanje, J. A. A. "Comparative in Vitro Activity of Five Quinoline Derivatives and Five Other Antimicrobial Agents Used in Oral Therapy." In Ciprofloxacin. Vieweg+Teubner Verlag, 1986. http://dx.doi.org/10.1007/978-3-663-01930-5_2.

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Filipowska, Anna, Wojciech Filipowski, Ewaryst Tkacz, and Monika Wujec. "Statistical Analysis of the Impact of Molecular Descriptors on Antimicrobial Activity of Thiourea Derivatives Incorporating 3-amino-1,2,4-triazole Scaffold." In Innovations in Biomedical Engineering. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-70063-2_19.

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Ambhore, Ajay N. "An Efficient Green Synthesis of Diphenyl Pyrazol-4-Yl-Thiopyridin-4-Yl-1,3,4-Oxadiazole Derivatives and Evaluation of Their Antimicrobial and Antioxidant Activity." In Modern Green Chemistry and Heterocyclic Compounds. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-3.

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Penta, Santhosh. "Antimicrobial Agents." In Advances in Structure and Activity Relationship of Coumarin Derivatives. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-803797-3.00002-3.

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Dutta, Joydeep, and Pradip Dutta. "Antimicrobial Activity of Chitin, Chitosan and Their Oligosaccharides." In Chitin, Chitosan, Oligosaccharides and Their Derivatives. CRC Press, 2010. http://dx.doi.org/10.1201/ebk1439816035-c15.

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Durgadevi, Ravindran, and Arumugam Veera Ravi. "Synthetic Derivatives from Marine Natural Products as Potential Antimicrobial Drugs." In Frontiers in Antimicrobial Agents. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815080148123030016.

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The marine environment havens a massive number of species that are the source of a wide range of structurally diverse bioactive secondary metabolites. The importance of marine natural products (MNPs) in drug discovery has been documented extensively with their impact on the development of existing drugs. Despite the promising activity of MNPs, most of them suffer from their complex structures, instability, and poor solubility. The synthetic derivatives of natural products cover the chemical derivatization of scaffolds isolated from marine sources and are highly applicable as chemical biosynthe
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Pal, Pinki. "Recent advances in syntheses and antibacterial activity of novel furan derivatives." In Heterocyclic Chemistry - New Perspectives [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1004117.

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Microbial resistance has turned into a global issue due to the ineffectiveness of currently available antimicrobial medicines. In the realm of medicinal chemistry, furan derivatives have taken on a special position. An essential synthetic technique in the search for new drugs is the inclusion of the furan nucleus. Due to the remarkable therapeutic efficacy of furan-related medicines, medicinal chemists have been inspired to create numerous innovative antibacterial agents. Due to the numerous methods by which furans derivatives can be made as well as their numerous structural reactions, the fie
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Conference papers on the topic "Antimicrobial activity of cinnoline derivatives"

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Al-Majedy, Yasmien, Ahmed Al-Amiery, and Redha Al-Bayati. "Novel quinazolinone derivatives: Synthesis and Antimicrobial Activity." In The 14th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00413.

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Mangalagiu, Violeta, Dorina Amariucai-Mantu, Vasilichia Antoci, Dumitrela Diaconu, and Ionel I. Mangalagiu. "Azine derivatives with antimicrobial properties." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.87.

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Azine derivatives, especially pyridine, quinoline and their fused derivatives, are invaluable scaffolds in medicinal chemistry having a large variety of biological activities, antimicrobials including. In this work we present some recent results that we obtained in the field of azine with antibacterial, antifungal and antituberculosis activity. Some of the obtained results are very promising, the antimicrobial activity of some azine derivatives being spectacular.
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Smit, Biljana, Ivana Radojevic, Marijana Djukic, Ljiljana Comic, and Darko Asanin. "Antimicrobial Activity of Various Hydantoin Derivatives ." In 2nd International Electronic Conference on Medicinal Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a032.

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Babu, Kayathi Narendra, Tamatam Rekha, G. Sravya, Putta Ramachandra Reddy, Venkatapuram Padmavathi, and Grigory V. Zyryanov. "Synthesis and antimicrobial activity of bis(azolyl) urea derivatives." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087354.

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Lysytsya, Andriy, and Pavlо Kryvoshyya. "COMPARISON OF ANTIMICROBIAL ACTIVITY OF TWO POLYMERIC GUANIDINE DERIVATIVES." In GRUNDLAGEN DER MODERNEN WISSENSCHAFTLICHEN FORSCHUNG. European Scientific Platform, 2023. http://dx.doi.org/10.36074/logos-31.03.2023.23.

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Fulgheci, Ana Maria, Ioana Nicolau, Petre Ionita, et al. "STUDY OF THE ANTIMICROBIAL ACTIVITY OF SOME FERROCENE DERIVATIVES." In International Symposium "The Environment and the Industry". National Research and Development institute for Industrial Ecology, 2022. http://dx.doi.org/10.21698/simi.2022.ab16.

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Negreanu-Pirjol, Ticuta. "ANTIMICROBIAL ACTIVITY OF SOME TRANSITIONAL METAL COMPLEXES WITH PHENYLBIGUANIDE DERIVATIVES." In 15th International Multidisciplinary Scientific GeoConference SGEM2015. Stef92 Technology, 2015. http://dx.doi.org/10.5593/sgem2015/b61/s25.036.

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Sankar, P. Siva, K. Divya, G. Dinneswara Reddy, V. Padmavathi, and Grigory V. Zyryanov. "Synthesis, characterization and antimicrobial activity of azetidinone and thiazolidinone derivatives." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087379.

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Mangalagiu, Ionel, Violeta Mangalagiu, Costel Moldoveanu, Gheorghita Zbancioc, Ramona Danac, and Vasilichia Antoci. "Antimicrobial and anticancer activity of some hybrid azine/azole derivatives." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab07.

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Khachatryan, D. S., A. V. Kolotaev, V. N. Osipov, V. A. Yashkir, and K. R. Matevosyan. "Quaternary ammonium derivatives of 2-aminothiophene-3-carboxylates with antimicrobial activity." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087355.

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