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Serov, Dmitriy A., Ann V. Gritsaeva, Fatikh M. Yanbaev, Alexander V. Simakin, and Sergey V. Gudkov. "Review of Antimicrobial Properties of Titanium Dioxide Nanoparticles." International Journal of Molecular Sciences 25, no. 19 (2024): 10519. http://dx.doi.org/10.3390/ijms251910519.
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There is a growing interest in the utilization of metal oxide nanoparticles as antimicrobial agents. This review will focus on titanium dioxide nanoparticles (TiO2 NPs), which have been demonstrated to exhibit high antimicrobial activity against bacteria and fungi, chemical stability, low toxicity to eukaryotic cells, and therefore high biocompatibility. Despite the extensive research conducted in this field, there is currently no consensus on how to enhance the antimicrobial efficacy of TiO2 NPs. The aim of this review is to evaluate the influence of various factors, including particle size, shape, composition, and synthesis parameters, as well as microbial type, on the antibacterial activity of TiO2 NPs against bacteria and fungi. Furthermore, the review offers a comprehensive overview of the methodologies employed in the synthesis and characterization of TiO2 NPs. The antimicrobial activity of TiO2 exhibits a weak dependence on the microorganism species. A tendency towards increased antibacterial activity is observed with decreasing TiO2 NP size. The dependence on the shape and composition is more pronounced. The most pronounced antimicrobial potential is exhibited by amorphous NPs and NPs doped with inorganic compounds. This review may be of interest to specialists in biology, medicine, chemistry, and other related fields.
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Saputra, Kormil, Masruroh Masruroh, Hendra Santoso, and Retna Apsari. "Tapping into the Power of Sol-Gel Method for Enhanced Antimicrobial Activity of Titania Nanoparticles." Science and Technology Indonesia 9, no. 3 (2024): 546–55. http://dx.doi.org/10.26554/sti.2024.9.3.546-555.
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Increasing bacterial resistance to antibiotics has become a serious threat to global public health. In this context, this study aims to evaluate the antimicrobial activity of titanium dioxide nanoparticles (TiO2 NPS) synthesized using the sol-gel method. TiO2 NPS samples were prepared and characterized for morphology via field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analysis. Kirby-Bauer disc diffusion method was used to test the antimicrobial activity of TiO2 NPS against Gram positive bacteria Staphylococcus aureus, Gram negative bacteria Escherichia coli, and pathogenic fungus Aspergillus penicillioides. The results showed that TiO2 NPS effectively inhibited the growth of microorganisms, with significant inhibition zones especially against fungi. The antimicrobial mechanism of TiO2 NPS involves the formation of hydroxyl radicals and superoxide ions that damage the cell membrane of microorganisms. The implications of this study are the development of potential antimicrobial nanomaterials for biomedical and environmental applications, as well as the importance of considering the physical and chemical properties of TiO2 NPS in designing effective infection treatment strategies.
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Missier, Mary Sheloni, Mahesh Ramakrishnan, S. Veerasankar, C. Dhanalakshmi, Harish Ponniah, and Shanmugam Rajeshkumar. "Antibacterial Properties of Lemon Juice–Mediated Zinc Oxide Nanoparticle and Titanium Dioxide Nanoparticle." Journal of Pharmacy and Bioallied Sciences 16, Suppl 5 (2024): S4421—S4425. https://doi.org/10.4103/jpbs.jpbs_854_24.
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ABSTRACT Introduction: The emergence of antibiotic-resistant pathogenic bacteria has become a major global health concern, with the increasing prevalence of infections that are difficult to treat with conventional antibiotics. As a result, there is a critical need for alternative antimicrobial agents that can effectively control bacterial infections and combat the growing problem of antibiotic resistance. Materials and Methods: In this study, the antibacterial properties of lemon juice mediated zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO2 NPs) was evaluated against oral pathogens. The synthesized nanoparticles were characterized using UV-Vis spectroscopy. The antimicrobial activity of the nanoparticles was determined by the agar well diffusion assay. Results: Our results showed that both ZnO NPs and TiO2 NPs exhibited potent antimicrobial activity against both Streptococcus mutans and Streptococcus mitis. Our findings suggest that the antimicrobial activity of ZnO NPs and TiO2 NPs is attributed to the disruption of bacterial cell membrane integrity and inhibition of bacterial growth. Conclusion: Therefore, lemon juice mediated ZnO NPs and TiO2 NPs can be considered as promising antimicrobial agents for controlling bacterial infections.
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Fletes-Vargas, Gabriela, Rogelio Rodríguez-Rodríguez, Natalha Vicentina Pinto, et al. "TiO2 Nanoparticles Loaded with Polygonum cuspidatum Extract for Wound Healing Applications: Exploring Their Hemolytic, Antioxidant, Cytotoxic, and Antimicrobial Properties." Nanomaterials 15, no. 12 (2025): 926. https://doi.org/10.3390/nano15120926.
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The dry roots of Polygonum cuspidatum contain resveratrol, a compound known for its antimicrobial and protective effects against oxidative stress, which is associated with impaired wound healing. In this study, titanium dioxide nanoparticles (TiO2NPs) were loaded with a P. cuspidatum extract (TiO2-loaded extract NPs), and the resveratrol release profile, hemocompatibility, antioxidant, cytotoxic, and antimicrobial activities were evaluated. The results demonstrated that TiO2-loaded extract NPs exhibited antioxidant activity for DPPH (Inhibitory Concentration 50 (IC50) = 62.31 mg Trolox Equivalent (TE)/mL) and ABTS+ (IC50 = 4.8 mg TE/mL) assays, along with suitable hemocompatibility (3.02% at 10 mg/mL), in comparison with bulk TiO2 NPs. Additionally, temperature influenced the resveratrol release over time. The P. cuspidatum extract alone showed strong antibacterial activity, with a Minimal Inhibitory Concentration (MIC) of 5 µg/mL, TiO2-loaded extract NPs showed MIC values about 50 mg/mL, while bulk TiO2 NPs exhibited no antibacterial effect against the tested strains. In contrast, the P. cuspidatum extract, the TiO2-loaded extract NPs, and the bulk TiO2 NPs did not demonstrate antifungal activity against Candida albicans and C. glabrata. Moreover, TiO2-loaded extract NPs showed no cytotoxicity against the L-929 cell line at concentrations ranging from 1.5 to 150 µg/mL, unlike TiO2 NPs, which exhibited high cytotoxic concentrations between 9.4 and 300 µg/mL. These findings suggest that TiO2-loaded extract NPs effectively control the release of resveratrol and hold promises for applications in skin management and wound healing.
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Xing, Yage, Xuanlin Li, Xunlian Guo, et al. "Effects of Different TiO2 Nanoparticles Concentrations on the Physical and Antibacterial Activities of Chitosan-Based Coating Film." Nanomaterials 10, no. 7 (2020): 1365. http://dx.doi.org/10.3390/nano10071365.
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In this investigation, the effect of different concentrations of titanium dioxide (TiO2) nanoparticles (NPs) on the structure and antimicrobial activity of chitosan-based coating films was examined. Analysis using scanning electron microscopy (SEM) and atomic force microscopy (AFM) revealed that the modified TiO2 NPs were successfully dispersed into the chitosan matrix, and that the roughness of the chitosan-TiO2 nanocomposites were significantly reduced. Moreover, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses indicated that the chitosan interacted with TiO2 NPs and possessed good compatibility, while a thermogravimetric analysis (TGA) of the thermal properties showed that the chitosan-TiO2 nanocomposites with 0.05% TiO2 NPs concentration had the best thermal stability. The chitosan-TiO2 nanocomposite exhibited an inhibitory effect on the growth of Escherichia coli and Staphylococcus aureus. This antimicrobial activity of the chitosan-TiO2 nanocomposites had an inhibition zone ranging from 9.86 ± 0.90 to 13.55 ± 0.35 (mm). These results, therefore, indicate that chitosan-based coating films incorporated with TiO2 NPs might become a potential packaging system for prolonging the shelf-life of fruits and vegetables.
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Hamed, Moaaz T., Basant A. Bakr, Yahya H. Shahin, et al. "Novel Synthesis of Titanium Oxide Nanoparticles: Biological Activity and Acute Toxicity Study." Bioinorganic Chemistry and Applications 2021 (August 11, 2021): 1–14. http://dx.doi.org/10.1155/2021/8171786.
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Titanium oxide nanoparticles (TiO2 NPs) have been attracting numerous research studies due to their activity; however, there is a growing concern about the corresponding toxicity. Here in the present study, titanium oxide nanoparticles were newly synthesized using propolis extract followed by antimicrobial activity, cytotoxicity assay using human cancer cell lines, and acute toxicity study. The physicochemical characterization of the newly synthesized TiO2 NPs had average size = 57.5 nm, PdI = 0.308, and zeta potential = −32.4 mV. Antimicrobial activity assessment proved the superior activity against Gram-positive compared to Gram-negative bacteria and yeast (lowest MIC values 8, 32, and 32, respectively). The newly synthesized TiO2 NPs showed a potent activity against the following human cancer cell lines: liver (HepG-2) (IC50 8.5 µg/mL), colon (Caco-2), and breast (MDA-MB 231) (IC50 11.0 and 18.7 µg/mL). In vivo acute toxicity study was conducted using low (10 mg/kg) and high (1000 mg/kg) doses of the synthesized TiO2 NPs in albino male rats. Biochemistry and histopathology of the liver, kidney, and brain proved the safety of the synthesized TiO2 NPs at low dose while at high dose, there was TiO2 NPs deposit in different vital organs except the cerebral tissue.
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Hassan, H., K. I. Omoniyi, F. G. Okibe, A. A. Nuhu, and E. G. Echioba. "Evaluation of Antibacterial Potential of Biosynthesized Plant Leave Extract Mediated Titanium Oxide Nanoparticles using Hypheae Thiebeace and Anannos Seneglensis." Journal of Applied Sciences and Environmental Management 23, no. 10 (2019): 1795–804. http://dx.doi.org/10.4314/jasem.v23i10.5.
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The need for new antimicrobial agent has drawn attention on developing new and emerging materials based on nanoparticles with antimicrobial activity. The aim of this research was to evaluate the antibacterial activity of nanoparticles of titanium dioxide. A green synthesis of TiO2 nanoparticles was done using a plant extract of H. thelbiecea and Ananos seneglensisa The presence of various photochemical like flavonoids, steroids, polyphenols, and terpenoids was investigated by following standard biochemical methods. The titanium oxide nanoparticles (TiO2 NPs) synthesized was confirmed by their change of colour to brown and reddish brown due to the phenomenon of surface Plasmon resonance. The characterization studied was done by UV-vis spectroscopy, scanning electron microscopy (SEM), X-Ray diffraction (XRD) and Fourier Transmission infrared spectroscopy (FTIR). The green synthesized TiO2 NPs excitation was confirmed using UV–Vis spectrophotometer at 270 and 290 nm. SEM revealed that the synthesized TiO2 NPs are spherical and crystalline in nature. The overall sizes are 40 and 50 nm for H. thelbiecea and Ananos respectively. FTIR spectroscopy analysis showed the presence of flavonoid, polyphenols and amide groups likely to be responsible for the green synthesis of titanium oxide nanoparticles using H. thelbiecea and Ananos seneglensis aqueous leaf extracts .The XRD pattern showed the characteristic Bragg peaks of (111), (200), (220) and (311) facets of the anatase titanium oxide nanoparticles and confirmed that these nanoparticles are crystalline and spherical in nature. The two plants used to synthesized titanium oxide nanoparticle (H. thelbiecea and ananos seneglensisa) showed good antimicrobial activity against clinically important pathogens.. The antimicrobial study of TiO2 NPs shows that 20 μg/ml TiO2 NPs is effective for complete inactivation of Gram positive, Gram negative as well as fungal cultures. This effective microbial inactivation is mainly attributed to its ability to cause damage to the cell membrane.Keywords: Titanium oxide, phytochemicals, antimicrobial activity, H. thelbiecea, Ananos seneglensisa
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Ahmed, Dalia, Laith Yaaqoob, and Sehand Arif. "Biosynthesis of TiO2 nanoparticles using prodigiosin and evaluating its antibacterial activity against biofilm producing MDR- Acinetobacter baumannii." Al-Anbar Journal of Veterinary Sciences 13, no. 2 (2020): 137–51. http://dx.doi.org/10.37940/ajvs.2020.13.2.13.
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A rising number of hospital infections were caused by multi drug resistant A.baumannii. This microorganism has become a big global concern for clinicians. This study aimed to evaluate the antimicrobial activity of biosynthesized TiO2 nanoparticles against biofilm producing multi drug resistant A. baumannii. Bacteria were isolated from burn wounds. The selected isolate was identified using the routine biochemical assays, viteck 2, and confirmed by PCR technique, targeting the 16S rRNA and blaOXA-51 genes. Antimicrobial susceptibility tests were performed using Viteck 2 system and the biofilm production was tested by using microtiter plate method. S marcescens was used for production of the prodigiosin which characterized later by UV-visible spectroscopy and then was used for biosynthesis of titanium dioxide nanoparticles (TiO2) NPs. Atomic force microscopy, X-ray diffractometer and field emission scanning electron microscopy were used for characterization of TiO2 NPs. Antimicrobial activity of TiO2 NPs was examined by well diffusion assay using concentration of 0.4- 0.006 mg/ml. The studied isolate was beta-lactamase producer and showed resistance to aminoglycosides, quinolones, furanes and trimethoprim/ sulphonamide, PCR amplification of 16S rRNA and blaOXA-51 genes was used for detection of A baumannii. The selected isolate was a strong biofilm producer with 5.9 times more than the OD values of the control. Atomic force microscopy images showed that the synthesized TiO2 NPs were in spherical shape with an average diameter of 67.49 nm. The TiO2 NPs inhibited the bacterial growth at concentrations of ≥ 0.1mg/ ml and a maximum zone of inhibition recorded was 22 mm at concentration of 0.4 mg/ ml. Biosynthesis of TiO2 NPs using prodigiosin was showed a promising antibacterial activity against strong biofilm producing MDR- A. baumannii.
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Metryka, Oliwia, Daniel Wasilkowski, Anna Nowak, Małgorzata Adamczyk-Habrajska, and Agnieszka Mrozik. "Impact of an Engineered Copper-Titanium Dioxide Nanocomposite and Parent Substrates on the Bacteria Viability, Antioxidant Enzymes and Fatty Acid Profiling." International Journal of Molecular Sciences 21, no. 23 (2020): 9089. http://dx.doi.org/10.3390/ijms21239089.
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Due to the systematic increase in the production of nanomaterials (NMs) and their applications in many areas of life, issues associated with their toxicity are inevitable. In particular, the performance of heterogeneous NMs, such as nanocomposites (NCs), is unpredictable as they may inherit the properties of their individual components. Therefore, the purpose of this work was to assess the biological activity of newly synthesized Cu/TiO2-NC and the parent nanoparticle substrates Cu-NPs and TiO2-NPs on the bacterial viability, antioxidant potential and fatty acid composition of the reference Escherichia coli and Bacillus subtilis strains. Based on the toxicological parameters, it was found that B. subtilis was more sensitive to NMs than E. coli. Furthermore, Cu/TiO2-NC and Cu-NPs had an opposite effect on both strains, while TiO2-NPs had a comparable mode of action. Simultaneously, the tested strains exhibited varied responses of the antioxidant enzymes after exposure to the NMs, with Cu-NPs having the strongest impact on their activity. The most considerable alternations in the fatty acid profiles were found after the bacteria were exposed to Cu/TiO2-NC and Cu-NPs. Microscopic images indicated distinct interactions of the NMs with the bacterial outer layers, especially in regard to B. subtilis. Cu/TiO2-NC generally proved to have less distinctive antimicrobial properties on B. subtilis than E. coli compared to its parent components. Presumably, the biocidal effects of the tested NMs can be attributed to the induction of oxidative stress, the release of metal ions and specific electrochemical interactions with the bacterial cells.
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Matei, Ecaterina, Carmen Gaidau, Maria Râpă, et al. "Sustainable Rabbit Skin Glue to Produce Bioactive Nanofibers for Nonactive Wound Dressings." Materials 13, no. 23 (2020): 5388. http://dx.doi.org/10.3390/ma13235388.
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This paper assessed the collagen glue (Col) from rabbit skin for use as a raw material in combination with different water-based dispersants of antimicrobial agents such as ZnO NPs, TiO2 NPs doped with nitrogen and Ag NPs (TiO2-N-Ag NPs), and chitosan (CS) for the production of biocompatible and antimicrobial nanofibers. The electrospun nanofibers were investigated by scanning electron microscopy (SEM), attenuated total reflectance in conjunction with Fourier-transform infrared spectroscopy (ATR-FT-IR) analyses and antioxidant activity. The biocompatibility of electrospun nanofibers was investigated on cell lines of mouse fibroblast NCTC (clone L929) using MTT test assays. Antimicrobial activity was performed against Escherichia coli and Staphylococcus aureus bacteria and Candida albicans pathogenic fungus. Electrospun antimicrobial nanofibers based on collagen glue achieved reduction in the number of viable microorganisms against both fungi and bacteria and exhibited multiple inhibitory actions of fungal and bacterial strains. The electrospun nanofibers showed average dimension sizes in the range of 30–160 nm. The results indicated that both Col/TiO2-N-Ag NPs and Col/CS formulations are suitable for cell proliferation and may be useful for producing of nonactive wound dressings.
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Dharmarajan, P., P. Sathishkumar, S. Gracelin Juliana, G. Ramanathan, and S. C. Vella Durai. "Phytosynthesis of titanium dioxide nanoparticles using Cynodon dactylon leaf extract and their antibacterial activity." Semiconductor Physics, Quantum Electronics and Optoelectronics 27, no. 03 (2024): 287–93. http://dx.doi.org/10.15407/spqeo27.03.287.
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Due to use of nanoparticles, nanotechnology has become an important area of research penetrating in all the fields of science and technology including medicinal chemistry. Titanium dioxide nanoparticles (TiO2 NPs) play an important role in biotechnology and nanomedicine because of their antimicrobial effect against many pathogens such as bacteria, fungus, viruses and yeast. In this article, we propose an eco-friendly phytosynthesis method of TiO2 NPs using aqueous leaf extract of Cynodon dactylon herbal plant as a reducing agent. The formation of TiO2 NPs by plant bio-molecules involved in the reduction of metal ions to nanoparticles is demonstrated. The synthesized TiO2 NPs are analyzed using X-ray diffraction analysis, Fourier transform infrared spectroscopy, laser Raman spectroscopy and field emission scanning electron microscopy. The antibacterial activity of the TiO2 NPs against gram-positive bacterial pathogens like Bacillus subtilis and Staphylococcus aureus as well as gram-negative bacterial pathogen like Escherchia coli is tested. The obtained results demonstrate potent bactericidal activity of the TiO2 NPs.
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Al-Balakocy, NG, TM Hassan, SY Aly, SH Abd Elsalam, and Mahmoud Hamouda Elshakankery. "Using nano technology for imparting PET/C blended fabric new functional performance properties." Journal of Engineered Fibers and Fabrics 17 (January 2022): 155892502211013. http://dx.doi.org/10.1177/15589250221101385.
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This article, discuss the effect of finishing polyester/cotton blended fabric (PET/C) with alkali and Titanium dioxide nanoparticles (TiO2 NPs) simultaneously. The treatment conditions such as NaOH and TiO2 NPs concentrations, reaction temperature and duration will be investigated. The effect of addition NPs on alkaline treatment conditions will prove through weight loss and carboxylic content. The ability of PET/C fabrics for loading with NPs during alkaline treatment was investigated by using SEM, EDX, and FTIR measurements. The effect of finishing of PET/C blended fabric with the suggested method on antimicrobial activity and ultraviolet protection was investigated. The simultaneous finishing of PET/C blended fabrics with alkali and TiO2 NPs showed excellent ultraviolet protection and high antimicrobial activity against Gram-positive ( Bacillus mycoides), Gram-negative ( Escherichia coli), and nonfilamentous fungus ( Candida albicans). The functional performance imparted to PET/C fabrics by the suggested approach are durable in repeated laundering processes, even after five Launder-Ometer washes.
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Pušnik Črešnar, Klementina, Alexandra Aulova, Dimitrios N. Bikiaris, Dimitra Lambropoulou, Katja Kuzmič, and Lidija Fras Zemljič. "Incorporation of Metal-Based Nanoadditives into the PLA Matrix: Effect of Surface Properties on Antibacterial Activity and Mechanical Performance of PLA Nanoadditive Films." Molecules 26, no. 14 (2021): 4161. http://dx.doi.org/10.3390/molecules26144161.
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In this work, the modification process of poly(lactic acid) (PLA) with metal-based nanoparticle (NPs) additives (Ag, ZnO, TiO2) at different loading (0.5, 1.0, and 2.5 wt%) and by melt-mix extrusion method followed by film formation as one of the advantageous techniques for industrial application have been investigated. PLA nanoparticle composite films (PLA-NPs) of PLA-Ag, PLA-ZnO, PLA-TiO2 were fabricated, allowing convenient dispersion of NPs within the PLA matrix to further pursue the challenge of investigating the surface properties of PLA-NPs reinforced plastics (as films) for the final functional properties, such as antimicrobial activity and surface mechanical properties. The main objective was to clarify how the addition of NPs to the PLA during the melt extrusion process affects the chemistry, morphology, and wettability of the surface and its further influence on the antibacterial efficiency and mechanical properties of the PLA-NPs. Therefore, the effect of Ag, ZnO, and TiO2 NPs incorporation on the morphology (SEM), elemental mapping analysis (SEM-EDX), roughness, surface free energy (SFE) of PLA-NPs measured by goniometry and calculated by OWRK (Owens, Wendt, Rabel, and Kaelble) model was evaluated and correlated with the final functional properties such as antimicrobial activity and surface mechanical properties. The developed PLA-metal-based nanocomposites, with improved mechanical and antimicrobial surface properties, could be used as sustainable and biodegradable materials, offering desirable multifunctionalities not only for food packaging but also for cosmetics and hygiene products, as well as for broader plastic products where antimicrobial activity is desirable.
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Abu-Dalo, Muna A., Ayat Bozeya, Zaid Sawalmeh, Borhan Albiss, Nour Alnairat, and Rund Abu-Zurayk. "Antifouling polymeric nanocomposite membrane based on interfacial polymerization of polyamide enhanced with green TiO2 nanoparticles for water desalination." PeerJ Analytical Chemistry 5 (June 14, 2023): e26. http://dx.doi.org/10.7717/peerj-achem.26.
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In the present investigation, the preparation and characterization of polyamide/TiO2 as thin film nanocomposites (TFN) for brackish water desalination was investigated. TiO2 nanoparticles (NPs) were synthesized by a green method using thyme plant extract as a reducing and capping agent. The TiO2 NPs was successfully prepared in pure crystalline anatase phase with 15 nm size, and −33.1 mV zeta potential. The antimicrobial tests confirmed the antimicrobial activity of TiO2 against gram-positive and gram-negative bacteria. In addition, TiO2 NPs showed a good photocatalytic activity in degradation of methylene blue dye. TFN based on interfacial polymerization was enhanced by embedding 5% of the greenly synthesized TiO2 NPs within the polyamide thin film active layer. The incorporation of TiO2 NPs was confirmed by SEM, atomic force microscope (AFM), surface wettability, and FTIR. Membranes performance was investigated based on flux, salt rejection and fouling resistance. The antifouling was examined using bovine serum albumin (BSA) as protein fouling by dead-end cell filtration system at 2 bar. The results showed the TFN increased in water flux by 40.9% and a slight decrease in NaCl rejection (6.3%) was observed, with enhancement in antifouling properties. The flux recovery rate of the modified TFN membranes after fouling with BSA solution was enhanced by 21.5% (from 61.7% for TFC to 83.2% for TFN). Also, they demonstrated remarkable anti-biofouling behavior against both bacterial strains.
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Ahmed, Amal Qasim, Sattar Jabbar Abdul-Zahra Al-Hmedat, Dunya Malhan Hanweet, and Julfikar Haider. "Assessing the Antifungal Activity of a Soft Denture Liner Loaded with Titanium Oxide Nanoparticles (TiO2 NPs)." Dentistry Journal 11, no. 4 (2023): 90. http://dx.doi.org/10.3390/dj11040090.
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Aim: Soft denture lining materials are susceptible to be colonized by different microorganisms, especially by Candida albicans (C. albicans), causing denture-induced stomatitis. This study was designed to evaluate the effectiveness of incorporating titanium dioxide nanoparticles (TiO2 NPs) into a soft denture liner towards reducing microbial activity. Method: A total of 40 PEMA-TiO2 nanocomposites samples were fabricated by adding 0.0 wt.% (control), 1.0 wt.%, 1.5 wt.%, and 2 wt.% TiO2 NPs to a heat cured soft denture lining material (polyethyl methacrylate, PEMA). The prepared samples were divided into four groups (n = 10) according to the content of TiO2 NPs. The uniformity of TiO2 NPS distribution within the denture liner matrix was assessed using a Scanning Electron Microscope (SEM). The viable count of C. albicans was evaluated to test the antifungal resistance of the developed composite. Results: The SEM images showed fairly homogeneous dispersion, with patches of TiO2 NPs agglomeration within the PEMA matrix and an increasing concentration of NPs with higher NP content. The particle map and EDX analysis confirmed the evidence of the TiO2 NPs. The mean viable count results for the control (0.0 wt.%) and 1.0 wt.%, 1.5 wt.%, and 2 wt.% TiO2 groups were 139.80, 12.00, 6.20, and 1.00, respectively, with a significant difference from the control group (p < 0.05). The antifungal activity also increased with the increase in the concentration of TiO2 NPs. Conclusions: The addition of TiO2 NPs into a heat-cured soft denture liner provided antifungal activity as evidenced by the reduced colonization of C. albicans. The antimicrobial activity of the liner material increased with the increased concentration of TiO2 NPS.
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Zafar, Naheed, Bushra Uzair, Muhammad Bilal Khan Niazi, et al. "Fabrication & Characterization of Chitosan Coated Biologically Synthesized TiO2 Nanoparticles against PDR E. coli of Veterinary Origin." Advances in Polymer Technology 2020 (January 20, 2020): 1–13. http://dx.doi.org/10.1155/2020/8456024.
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Treatment of pandrug resistant (PDR) Escherichia coli strain is the leading causative agent of bovine mastitis worldwide. Hence, becoming a potential threat to veterinary and public health. Therefore, to control the infection new nontoxic, biocompatible antimicrobial formulation with enhanced antibacterial activity is massively required. Current study was planned to synthesize chitosan coated titanium dioxide nanoparticles (CS-NPs coated TiO2). Coating was being done by chitosan nanoparticles (CS-NPs) using ionic gelation method. Aqueous solution of Moringa concanensis leaf extract was used to synthesize titanium dioxide nanoparticles (TiO2 NPs). The synthesized nanoformulations were characterized by using XRD, SEM, and FTIR. X-ray diffraction (XRD) analysis indicated the crystalline phase of TiO2 NPs and CS-NPs coated TiO2 NPs. Scanning Electron Microscopy (SEM) confirmed spherical shaped nanoparticles size of chitosan NPs ranging from 19–25 nm and TiO2 NPs 35–50 nm. Thesize of CS-NPs coated TiO2 NPs was in the range of 65–75 nm. The UV-Vis Spectra and band gap values illustrated the red shift in CS-NPs coated TiO2 NPs. Fourier transform infrared (FTIR) spectroscopy confirmed the linkages between TiO2 NPs and chitosan biopolymer, Zeta potential confirmed the stability of CS-NPs coated TiO2 NPs by showing 95 mV peak value. In-vitro antibacterial activity of CS-NPs coated TiO2 NPs and Uncoated TiO2 NPs was evaluated by disc diffusion method against PDR strain of E. coli isolated from mastitic milk samples. The antibacterial activity of all the synthesized nanoformulations were noted and highest antibacterial activity was shown by CS-NPs coated TiO2-NPs against pandrug resistant (PDR) E. coli strain with the prominent zone of inhibition of 23 mm. Morphological changes of E. coli cells after the treatment with MIC concentration (0.78 μg/ml) of CS-NPs coated TiO2 NPs were studied by transmission electron microscopy TEM showedrigorous morphological defectand has distorted the general appearance of the E. coli cells. Cytotoxicity (HepG2 cell line) and hemolytic (human blood) studies confirmed nontoxic/biocompatible nature of CS-NPs coated biologically synthesized TiO2 NPs. The results suggested that biologically synthesized and surface modified TiO2 NPs by mucoadhesive polysaccharides (e.g. chitosan) coating would be an effective and non-toxic alternative therapeutic agent to be used in livestock industry to control drug resistant veterinary pathogens.
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Amirah Shafie, Nur Fathin, Nazira Syahira Zulkifli, Roshafima Rasit Ali, Zatil Izzah Tarmizi, and Syazwani Mohd Faizo. "Green Synthesis of Titanium Dioxide Nanoparticles Using Extraction of Psidium Guajava for Smart Packaging Application." Journal of Research in Nanoscience and Nanotechnology 11, no. 1 (2024): 16–23. http://dx.doi.org/10.37934/jrnn.11.1.1623.
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This research aims to investigate the application of smart packaging in exhibited antimicrobial activity against bacteria such as E. coli and S. aureus. An alternative of non-degradable plastic based on the green synthesis of titanium dioxide nanoparticles (TiO2 NPs) and biofilm of Chitosan-TiO2 NPs has been developed. TiO2 NPs are known to be effective antimicrobial agents synthesized from Psidium Guajava leaves. Chitosan is a natural carbohydrate polymer employed in smart biofilm for packaging for a long time due to its biodegradability, biocompatibility, and low toxicity. Chitosan-Titanium dioxide Biofilm underwent characterization study through XRD, FTIR and FESEM. The analysis has shown the spectra minima at 380 nm from UV- vis analysis represents TiO2 bands, the small size of titanium dioxide nanoparticle at 5-10 nm obtained from FESEM analysis, the crystallographic nature is "plane of TiO2 anatase" through XRD analysis, and the main functional group involved are carboxylic group O–H and Ti-O-Ti from FTIR analysis. The titanium dioxide nanoparticle was incorporated into chitosan, and the effectiveness of antimicrobial properties of the incorporated packaging was studied and recorded by observing the inhabitant zone. Consequently, TiO2-Chitosan efficiently suppresses the growth of bacterial colonies. The study only considers the antimicrobial packaging used, which will be disposed of generally for biodegradable packaging.
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Khalil, Mennatullah, and Lamis Enaba. "Influence of Antimicrobial Nanoparticles on Flexural Strength and Hardness of Polymethylmethacrylate." Open Access Macedonian Journal of Medical Sciences 9, no. D (2021): 314–18. http://dx.doi.org/10.3889/oamjms.2021.7565.
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BACKGROUND: Polymethylmethacrylate (PMMA) is commonly used for dental appliances but has several shortcomings that could benefit from improvement with the use of nanoparticles (NPs). AIM: The purpose of this study was to modify PMMA with three different antimicrobial NPs; Graphene oxide nanosheets (nGO), Titanium dioxide NPs (TiO2 NPs) and curcumin (CUR)-loaded graphene oxide nanosheets alone, and in combination and assess the flexural strength and hardness of the different groups. MATERIALS AND METHODS: The material used in this study was chemically cured PMMA that was modified with nGO, TiO2 NPs and GOCUR alone and in combination to give 6 groups; Group A: PMMA, Group B: PMMA with nGO, Group C: PMMA with TiO2 NPs, Group D: PMMA with TiO2 and GO NPs, Group E: PMMA with GOCUR, and Group F: PMMA with TiO2 NP, and GOCUR. The Six groups were tested for flexural strength and hardness. Statistical analysis was and data were expressed as means and standard deviation. Data was explored for normality using the Kolmogorov-Smirnov test of normality. The ANOVA test was used to compare between groups, followed by Bonferroni’s post hoc test for pairwise comparison. The significance level was set at p ≤ 0.05. RESULTS: The highest flexural strength was recorded in Group C (52.26 ± 5.48 MPa) and the lowest value was in Group A (24.94 ± 5.37 MPa). The highest hardness was recorded in Group F (23.29 ± 0.8 HV) and the lowest value was in Group A (15.88 ± 1.02 HV). CONCLUSION: The modification of PMMA with NPs with proven antimicrobial activity can increase the flexural strength and hardness of the material. GO, TiO2 and, GOCUR NPs were each used alone and in different combinations, and all the groups displayed higher flexural strength and hardness than the unmodified PMMA.
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Melchor-Moncada, Jhon Jairo, Santiago Vasquez-Giraldo, Augusto Zuluaga-Vélez, Lina Marcela Orozco, Luz Angela Veloza, and Juan Carlos Sepúlveda-Arias. "Bioconjugation of Serratiopeptidase with Titanium Oxide Nanoparticles: Improving Stability and Antibacterial Properties." Journal of Functional Biomaterials 15, no. 10 (2024): 300. http://dx.doi.org/10.3390/jfb15100300.
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Antimicrobial resistance (AMR) poses a significant global health threat, necessitating the development of novel antibacterial strategies. Serratiopeptidase (SP), a metalloprotease produced by bacteria such as Serratia marcescens, has gained attention not only for its anti-inflammatory properties but also for its potential antibacterial activity. However, its protein nature makes it susceptible to pH changes and self-proteolysis, limiting its effectiveness. This study aimed to increase both the enzymatic stability and antibacterial activity of serratiopeptidase through immobilization on titanium oxide nanoparticles (TiO2-NPs), leveraging the biocompatibility and stability of these nanomaterials. Commercial TiO2-NPs were characterized using TGA/DTG, FT-IR, UV–Vis, and XRD analyses, and their biocompatibility was assessed through cytotoxicity studies. Serratiopeptidase was produced via fermentation using the C8 isolate of Serratia marcescens obtained from the intestine of Bombyx mori L., purified chromatographically, and immobilized on carboxylated nanoparticles via EDC/NHS coupling at various pH conditions. The optimal enzymatic activity was achieved by using pH 5.1 for nanoparticle activation and pH 5.5 for enzyme coupling. The resulting bioconjugate demonstrated stable proteolytic activity at 25 °C for 48 h. Immobilization was confirmed by FT-IR spectroscopy, and the Michaelis–Menten kinetics were determined. Notably, the bioconjugate exhibited two-fold greater antibacterial activity against E. coli than the free enzyme or TiO2-NPs at 1000 µg/mL. This study successfully developed a serratiopeptidase–TiO2 bioconjugate with enhanced enzymatic stability and antibacterial properties. The improved antibacterial activity of the immobilized enzyme presents a promising approach for developing new tools to combat antimicrobial resistance, with potential applications in healthcare, food safety, and environmental protection.
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David, Madalina Elena, Rodica Mariana Ion, Ramona Marina Grigorescu, et al. "Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiO2 Nanoparticles for Potential Biomedical Applications." Nanomaterials 12, no. 2 (2022): 239. http://dx.doi.org/10.3390/nano12020239.
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This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO2 nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO2 NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial.
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Tsakiridou, Melpomeni, Ioannis Tsagkalias, Rigini M. Papi, and Dimitris S. Achilias. "Synthesis of Novel Nanocomposite Materials with Enhanced Antimicrobial Activity based on Poly(Ethylene Glycol Methacrylate)s with Ag, TiO2 or ZnO Nanoparticles." Nanomaterials 14, no. 3 (2024): 291. http://dx.doi.org/10.3390/nano14030291.
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The aim of this investigation was to prepare novel hybrid materials with enhanced antimicrobial properties to be used in food preservation and packaging applications. Therefore, nanocomposite materials were synthesized based on two stimuli-responsive oligo(ethylene glycol methacrylate)s, namely PEGMA and PEGMEMA, the first bearing hydroxyl side groups with three different metal nanoparticles, i.e., Ag, TiO2 and ZnO. The in situ radical polymerization technique was employed to ensure good dispersion of the nanoparticles in the polymer matrix. FTIR spectra identified the successful preparation of the corresponding polymers and XRD scans revealed the presence of the nanoparticles in the polymer matrix. In the polymer bearing hydroxyl groups, the presence of Ag-NPs led to slightly lower thermal stability as measured by TGA, whereas both ZnO and TiO2 led to nanomaterials with better thermal stability. The antimicrobial activity of all materials was determined against the Gram-negative bacteria E. coli and the Gram-positive S. aureus, B. subtilis and B. cereus. PEGMEMA nanocomposites had much better antimicrobial activity compared to PEGMA. Ag NPs exhibited the best inhibition of microbial growth in both polymers with all four bacteria. Nanocomposites with TiO2 showed a very good inhibition percentage when used in PEGMEMA-based materials, while in PEGMA material, high antimicrobial activity was observed only against E. coli and B. subtilis, with moderate activity against B. cereus and almost absent activity against S. aureus. The presence of ZnO showed antimicrobial activity only in the case of PEGMEMA-based materials. Differences observed in the antibacterial activity of the polymers with the different nanoparticles could be attributed to the different structure of the polymers and possibly the more efficient release of the NPs.
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Jabbar Shawkat, Sabar, and Khosrow Chehri. "Antimicrobial Potential of Titanium Dioxide Nanoparticles in Urinary Tract Infections: An Experimental Study on the Growth Inhibitory Activity and Biofilm Inhibition." Avicenna Journal of Clinical Microbiology and Infection 8, no. 4 (2021): 123–29. http://dx.doi.org/10.34172/ajcmi.2021.23.
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Background: T Microorganisms cause many diseases for the human body such as urinary tract infection and, therefore, it is highly important to eliminate and control them. Bacterial resistance to different types of antibiotics was increased and it is necessary to find alternative agents to eliminate these microbes. Methods: This study aimed was to evaluate the antimicrobial effect of different concentrations of titanium dioxide nanoparticles (TiO2 NPs) on some gram-positive bactria, gram-negative bacteria, and Candida albicans. TiO2 NPs were synthesized using the chemical methods, coated with carboxymethyl cellulose (CMC) and prepared in different concentrations (0.098, 0.196, 0.392, 0.784, 1.568, and 3.136 mg/mL). Eventually, a minimum inhibitory concentration (MIC) and a minimum biofilm inhibitory concentration (MBIC) were applied to investigate the effect of TiO2 NPs on microorganisms. Results: According to the study results, the MICs of TiO2 NPs were found to be 1.489, 1.208, and 1.166 mg/ mL for Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae as the Gram-negative bacteria, respectively; and they were discovered to be 0.512, 0.830, and 0.707 mg/mL for Streptococcus pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis as the Gram-positive bacteria, respectively. As for C. albicans, as the yeast strain, MIC was 0.253 mg/ mL. The MBIC of more than 90% of TiO2 NPs was 6.25 mg/mL for both Gram-negative and Gram-positive bacterial types and 1.562 mg/mL for C. albicans. Conclusions: It was concluded that TiO2 NPs were effective antimicrobial agents for Gram-positive bacteria, Gram-negative bacteria, and C. albicans, but their inhibitory effect on yeast was greater than that of bacteria.
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Gutarowska, Beata, Edyta Matyjas-Zgondek, Piotr Kulpiński, Marta Mroczyńska-Florczak, and Eugeniusz Rutkowski. "Long-Lasting Photocatalytic and Antimicrobial Activity of Cotton Towels Modified with TiO2 and ZnO Nanoparticles." Catalysts 11, no. 8 (2021): 952. http://dx.doi.org/10.3390/catal11080952.
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This study aimed to evaluate the durability of the photocatalytic and antimicrobial activities of ZnO and TiO2 nanoparticles (NPs)-modified 100% cotton terry textiles. SEM-EDX confirmed the long-lasting durability of the washing materials, and TGA analysis revealed that ZnO and TiO2 NPs can be found on the terry fabric surface; however, the amount of NPs decreased 10 times after 15 washes and 1.6 times after the subsequent 15 washes. The efficiency of self-cleaning properties and antimicrobial activity against five microorganisms (Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 10536, Candida albicans ATCC 10231, Aspergillus niger ATCC 16404, and Bacillus subtilis NCAIM 01644) depended on UVA/B radiation intensity. The increase in UVA/B radiation intensity from 400 to 1400 µW/cm2 significantly increases the effectiveness of photocatalysis. Long-lasting self-cleaning properties characterised the tested fabric; however, stronger photocatalytic efficiency was observed in light with a greater intensity of UVA/B radiation. At the UVA/B radiation intensity of 1400 µW/cm2, a biocidal effect (R = 100%) against all tested microorganisms (E. coli, S. aureus. B. subtilis, C. albicans, and A. niger) was observed on the surface of materials. The lower UVA/B radiation intensity (400 µW/cm2) and 30 wash cycles reduce the antimicrobial activity of the material (R = 65.4–99.4%) for B. subtilis, C. albicans, and A. niger. The antimicrobial activity of washed materials modified with TiO2/ZnO nanoparticles can be increased by irradiation with a light bulb (1400 µW/cm2).
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Qamandar, Marwah Amer, and Taha M. Rashid. "Exploring the Biological Applications of TiO2 and AgNPs: Innovations and Impacts." International Journal of Medical Science and Dental Health 10, no. 08 (2024): 12–26. http://dx.doi.org/10.55640/ijmsdh-10-08-02.
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The foundation for crucial industrial applications and rapid expansion is now nanotechnology. The nanoparticles are synthesized by various methods that are classified into bottom-up or top-down method Ag NPs show antimicrobial effect and are possibly useful in the areas of food preservation, antibacterial surfaces and tissues, nanomedicine, and dentistry, TiO2 NPs are one of the most widely generated metal oxide NPs, which is typically because of its adaptable and acceptable qualities that come from the optical, electrical, chemical properties, and physical. Its various kinds of minerals include anatase, rutile, and brookite; generally, the former has more TiO2 due to increased photocatalytic activity. Despite TiO2 NPs' relevance, very little work has been done to generate them sustainably. Nanoparticles have many applications likes engineering of tissue antimicrobial applications, and regenerative medicine, carrier for drug delivery, cancer Treatment, the major aim of the essay to provide overview about silver and titanium nanoparticles their application in medicine especially how the penetration occur
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Liao, Chengzhu, Yuchao Li, and Sie Chin Tjong. "Visible-Light Active Titanium Dioxide Nanomaterials with Bactericidal Properties." Nanomaterials 10, no. 1 (2020): 124. http://dx.doi.org/10.3390/nano10010124.
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This article provides an overview of current research into the development, synthesis, photocatalytic bacterial activity, biocompatibility and cytotoxic properties of various visible-light active titanium dioxide (TiO2) nanoparticles (NPs) and their nanocomposites. To achieve antibacterial inactivation under visible light, TiO2 NPs are doped with metal and non-metal elements, modified with carbonaceous nanomaterials, and coupled with other metal oxide semiconductors. Transition metals introduce a localized d-electron state just below the conduction band of TiO2 NPs, thereby narrowing the bandgap and causing a red shift of the optical absorption edge into the visible region. Silver nanoparticles of doped TiO2 NPs experience surface plasmon resonance under visible light excitation, leading to the injection of hot electrons into the conduction band of TiO2 NPs to generate reactive oxygen species (ROS) for bacterial killing. The modification of TiO2 NPs with carbon nanotubes and graphene sheets also achieve the efficient creation of ROS under visible light irradiation. Furthermore, titanium-based alloy implants in orthopedics with enhanced antibacterial activity and biocompatibility can be achieved by forming a surface layer of Ag-doped titania nanotubes. By incorporating TiO2 NPs and Cu-doped TiO2 NPs into chitosan or the textile matrix, the resulting polymer nanocomposites exhibit excellent antimicrobial properties that can have applications as fruit/food wrapping films, self-cleaning fabrics, medical scaffolds and wound dressings. Considering the possible use of visible-light active TiO2 nanomaterials for various applications, their toxicity impact on the environment and public health is also addressed.
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Bano, Fareha. "Green-Synthesized Titanium Dioxide Nanoparticles Inhibit and Eradicate the Biofilms of Pathogenic Bacteria Through Intracellular ROS Production." Microbiology Research 16, no. 2 (2025): 48. https://doi.org/10.3390/microbiolres16020048.
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Objectives: Bacterial infections, mainly due to rising antimicrobial resistance (AMR), are an immense global health threat, complicating treatment, prolonging illness, and increasing mortality. The WHO lists AMR as one of the major threats to human health. Biofilm plays a crucial role in AMR, protecting bacteria and promoting resistance. Targeting biofilms improves antibiotic efficacy and reduces chronic infections. Titanium dioxide nanoparticles (TiO2-NPs) have emerged as a promising candidate in drug delivery, diagnostics, and antimicrobial therapies due to their distinctive properties. Methods: Due to the challenge of AMR and the potential of green-synthesized nanoparticles, this study investigates antibiofilm activity and intracellular ROS production by TiO2-NPs produced from Linum usitatissimum seed extract. Results: The crystal size of LU-TiO2-NPs was determined as 8.024 nm, and TEM validated the average particle size as 14.30 ± 5.93 nm. FTIR confirmed the presence of the O-Ti-O bond near 684 cm−1. LU-TiO2-NPs effectively inhibited biofilms, reducing biofilms of Staphylococcus aureus MTCC 3160 and Escherichia coli ATCC 25922 by 79.96% and 71.85%, respectively. Microscopic analysis also showed a reduction in bacterial adherence and colonization. This inhibition was supported by the reduction in exopolysaccharides, a major biofilm component. The biofilm inhibition was likely mediated by the induction of intracellular ROS production by LU-TiO2-NPs. Furthermore, LU-TiO2-NPs successfully eradicated established biofilms of both the Gram +ve and Gram −ve bacteria. Conclusion: The findings demonstrate that TiO2-NPs hold significant promise in tackling biofilm-associated bacterial infections and may prove beneficial in addressing the escalating problem of AMR.
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Alhadrami, Hani A., and Raniyah A. M. Shoudri. "Titanium Oxide (TiO2) Nanoparticles for Treatment of Wound Infection." Journal of Pure and Applied Microbiology 15, no. 1 (2021): 437–51. http://dx.doi.org/10.22207/jpam.15.1.41.
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Wound infections is one of the major problems worldwide. Millions of people around the world require several medical treatments for wound infections. The extensive use of antibiotics to treat wound infection leads to emerging new microbial strains that are resistant to many antibiotics. There is a growing concern on the emergence and re-emergence of drug-resistant pathogens such as multi-resistant bacterial strains. Hence, the development of new antimicrobial compounds or the modification of those that already exist to improve antibacterial activity is a high research priority. Metallic nanoparticles (NPs) are considered as new alternative treatment for wound infection with superior antibacterial activity. In this study, new formulation of titanium oxide (TiO2) NPs with different sizes were synthesized and characterized. Genotoxicity, mutagenicity and antibacterial activities of TiO2 NPs against the causative agents of wound infection were investigated. Antibacterial activity of TiO2 NPs was conducted against three ATCC® bacterial strains: methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. The results clearly illustrate a superior antibacterial activity of all newly formulated TiO2 NPs against the most causative agents of wound infection. Most of our TiO2 NPs showed non-genotoxic and non-mutagenic results at the maximum concentrations. Findings of this study will enhance the future of the therapeutic strategies against the resistant pathogenic strains that cause wound infections.
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Alizadeh-Sani, Mahmood, Hamed Hamishehkar, Arezou Khezerlou, et al. "Kinetics Analysis and Susceptibility Coefficient of the Pathogenic Bacteria by Titanium Dioxide and Zinc Oxide Nanoparticles." Advanced Pharmaceutical Bulletin 10, no. 1 (2019): 56–64. http://dx.doi.org/10.15171/apb.2020.007.
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Purpose: The increase of bacterial resistance to common antibacterial agents is one of the major problems of health care systems and hospital infection control programs. In this study, antimicrobial activity of titanium dioxide (TiO2 ) and zinc oxide (ZnO) nanoparticles (NPs) was investigated against E. coli, Salmonella enteritidis, Listeria monocytogenes, and Staphylococcus aureus pathogenic bacteria by determining sensitivity coefficient and kinetics of bacterial death. Methods: Antimicrobial tests were performed with ~106 CFU/mL of each bacterium at baseline. At first, minimum inhibitory concentration (MIC) was concluded by the dilution method and then, death kinetic and susceptibility coefficient of NPs suspensions was determined at 0 to 360 min. treatment time. Results: The results of this study revealed that, the highest susceptibility was observed for L. monocytogenes (Z=0.025 mL/μg) to TiO2 NPs, whereas the lowest susceptibility was obtained in the reaction of ZnO NPs with S. enteritidis (Z=0.0033 mL/μg). The process of bacterial death in NPs suspension was assumed to follow first-degree kinetic and the survival ratio of bacteria decreased by the increase in treatment time. An increase in the concentration of NPs was seen to enhance the bactericidal action. Conclusion: Results showed that L. monocytogenes had higher sensitivity compared to S. enteritidis. The results of this study also demonstrated that TiO2 NPs have a strong antimicrobial effect in comparison with ZnO NPs and it could be employed to aid the control of pathogenic bacteria.
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Oliveira, Iracema Nascimento de, Raphaella Ingrid Santana Oliveira, Eduarda Bezerra Pereira, Francine Ferreira Padilha, Silvia Maria Egues, and Maria Lucila Hernández-Macedo. "Synthesis and photocatalytic effects of TiO2-Ag on antibiotic-resistant bacteria." Peer Review 5, no. 8 (2023): 45–61. http://dx.doi.org/10.53660/400.prw1014b.
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Titanium dioxide (TiO2) is a semiconductor metal oxide extensively studied due to its photocatalytic properties that can be applied in various areas. However, the catalytic performance of TiO2 is limited at the UV spectrum, and the silver doping to titanium dioxide (Ag-TiO2) can increase the catalytic performance for visible light. In this work, Ag-doped TiO2 nanoparticles were synthesized to evaluate photocatalytic activity against sensitive and methicillin-resistant Staphylococcus aureus frequently associated with skin infections. The sol-gel method followed by Ag doping was applied to NPs synthesis. NPs were characterized by UV-vis spectroscopy, scanning electron microscopy (SEM), UV-vis diffuse reflectance spectrophotometry (DRS), Semi-quantitative energy dispersive spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy. FTIR and EDS results confirmed the doping of silver in TiO2. MEV analysis evidenced spherical nanoparticles between 8.5 - 25.6 nm. The TiO2 nanoparticles combined with silver improved the antimicrobial effect of TiO2 under visible light at 180 min, however, the greatest antimicrobial effect was observed under UV light at 120 min.
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Moon, Kyoung-Suk, Eun-Joo Choi, Ji-Myung Bae, Young-Bum Park, and Seunghan Oh. "Visible Light-Enhanced Antibacterial and Osteogenic Functionality of Au and Pt Nanoparticles Deposited on TiO2 Nanotubes." Materials 13, no. 17 (2020): 3721. http://dx.doi.org/10.3390/ma13173721.
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This study aimed at evaluating the visible light mediated antimicrobial and osteogenic applications of noble metal, such as gold (Au) and platinum (Pt) coated titania (TiO2) nanotubes (NTs). In this study, the Au and Pt nanoparticles (NPs) were deposited on anodized 100 nm TiO2 NTs by ion plasma sputtering. The Au and Pt NPs were mainly deposited on the top surface layer of TiO2 NTs and showed light absorbance peaks around the 470 and 600 nm visible light region used in this study, as seen from the surface characterization. From the results of antibacterial activity test, Au and Pt NPs that were deposited on TiO2 NTs showed excellent antibacterial activity under 470 nm visible light irradiation due to the plasmonic photocatalysis based on the localized surface plasmon resonance effect of the Au and Pt NPs. In addition, alkaline phosphate activity test and quantitative real-time PCR assay of osteogenic related genes resulted that these NPs promoted the osteogenic functionality of human mesenchymal stem cells (hMSCs) under 600 nm visible light irradiation, because of the synergic effect of the photothermal scattering of noble metal nanoparticles and visible light low-level laser therapy (LLLT). Therefore, the combination of noble metal coated TiO2 NTs and visible light irradiation would be expected to perform permanent antibacterial activity without the need of an antibacterial agent besides promoting osteogenic functionality.
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Al-Salih, Moatasem, Syakirah Samsudin, and Siti Suri Arshad. "Synthesis and characterizations titanium dioxide nanocomposite by laser ablation for antimicrobial applications." Journal of Bacteriology & Mycology: Open Access 7, no. 4 (2019): 81–84. http://dx.doi.org/10.15406/jbmoa.2019.07.00249.
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A composite nanoparticle containing Titanium Dioxide is synthesized by pulsed laser ablation. Oxide nanoparticles NPs have wide ranges of physical, chemical and biological properties. The main advantages In the present work, studying the characterization of colloid TiO2 NPs were synthesis by PLAL and investigated the antibacterial activity of colloidal TiO2 NPs compared to the antibacterial activity of synthesized composite nanoparticles was tested against four different pathogen bacteria two-gram negative (Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae)), institute of bioscience UPM university kindly supplied these bacteria. The bacterial suspension was made and adjusted by comparison against 0.5Mc-Farland turbidity typical (5x107cell ml-1) tubes. It was further diluted to obtain a final of 5x106cell ml-1. All bacteria strains were culture in agar media. The media was inoculated by the 0.2ml/5ml with either the bacteria strains, then added 0.5ml of TiO2 nanoparticles at concentration 200, 400,600ml-1. The samples were incubated at 37°C. The bacterial growth was measured by optical density that absorbs strongly at 532nm wavelength. Conclusion that is the mean values of inhibition were calculated from triple evaluation in each assessment.
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Kőrösi, László, Botond Pertics, György Schneider, et al. "Photocatalytic Inactivation of Plant Pathogenic Bacteria Using TiO2 Nanoparticles Prepared Hydrothermally." Nanomaterials 10, no. 9 (2020): 1730. http://dx.doi.org/10.3390/nano10091730.
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Exploitation of engineered nanomaterials with unique properties has been dynamically growing in numerous fields, including the agricultural sector. Due to the increasing resistance of phytopathogenic microbes, human control over various plant pathogens in crop production is a big challenge and requires the development of novel antimicrobial materials. Photocatalytic active nanomaterials could offer an alternative solution to suppress the plant pathogens. In this work, titanium dioxide nanoparticles (TiO2 NPs) with high photocatalytic activity were synthesized by hydrothermal post-treatment of amorphous titania at different temperatures (250 °C or 310 °C) without using any additives or doping agents. The obtained samples were investigated through X-ray diffraction, N2-sorption measurements, diffuse reflectance UV-Vis spectroscopy, transmission electron microscopy, electron paramagnetic resonance spectroscopy, and X-ray photoelectron spectroscopy. The applied hydrothermal treatment led to the formation of TiO2 nanocrystallites with a predominant anatase crystal phase, with increasing crystallinity and crystallite size by prolonging treatment time. The photocatalytic activity of the TiO2 NPs was tested for the photo-degradation of phenol and applied for the inactivation of various plant pathogens such as Erwinia amylovora, Xanthomonas arboricola pv. juglandis, Pseudomonas syringae pv. tomato and Allorhizobium vitis. The studied bacteria showed different susceptibilities; their living cell numbers were quickly and remarkably reduced by UV-A-irradiated TiO2 NPs. The effectiveness of the most active sample prepared at 310 °C was much higher than that of commercial P25 TiO2. We found that fine-tuning of the structural properties by modulating the time and temperature of the hydrothermal treatment influenced the photocatalytic properties of the TiO2 NPs considerably. This work provides valuable information to the development of TiO2-based antimicrobial photocatalysts.
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Shalaby, Samy E., Naser Gad Al-Balakocy, Margrita K. Beliakova, and Abdelmageed M. Othman. "Effect of wet processing operations on the functional properties imparted to polyester fabrics loaded with different metal oxides NPs part II: Effect of the different sequences of dyeing." Journal of Engineered Fibers and Fabrics 16 (January 2021): 155892502110057. http://dx.doi.org/10.1177/15589250211005760.
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The present work aims at investigating the effect of applying different dyeing sequences on the imparted functional properties to partially hydrolysed and bleached PET and PET/CO fabrics loaded with TiO2, ZnO and SnO2 nanoparticles (NPs). The so obtained dyed fabrics have been characterized using SEM, EDX and FT-IR analytical techniques. The obtained results revealed that, an interaction has taken place between COOH groups created on dyed polyester fabrics and each of the applied NPs. Moreover, the effect of loading and sequence of dyeing wet operation on the functional performances of polyester fabrics was evaluated by estimating its antimicrobial efficacy and ultraviolet protection properties. The antimicrobial activity was tested against B. mycoides, E. coli and C. albicans. It has been found that, loading polyester fabrics with TiO2 and ZnO during dyeing process using exhaustion or after dyeing using pad-dry-cure methods paves the way for imparting outstanding antimicrobial activity even after five washing cycles. Moreover, the obtained results have also reviled that, the UPF values are dependent on the sequences of the loading of abovementioed NPs during or after dyeing wet operation.
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Hamdi, Hamida, Rania S. Rashwan, Abeer A. Abu-zaid, et al. "Efficacy of Titanium Dioxide Nanoparticles Using Juniperus phoenicea in Controlling Rice Weevil (Sitophilus oryzae) and Its Effect on the Microbial Contents and Nutritive Value of Grains." Journal of Biobased Materials and Bioenergy 18, no. 6 (2024): 1002–9. http://dx.doi.org/10.1166/jbmb.2024.2452.
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The rice weevil, Sitophilus oryzae is a primary pest attack many kinds of crops. It causes a lot of loss and reduces the economic values of products. The study investigated to determine the insecticidal effect of titanium dioxide nanoparticles using Juniperus phoenicea (TiO2 NPs) against the insect, and the nutritional and antimicrobial value of rice grains after treatment by TiO2 NPs was estimated. Adult was the target of bioassay of the biocomponent. Four concentrations were prepared as 30, 50, 80 and 100%. Some biochemical components were evaluated as response indicators of insect. Obtained data demonstrated significant differences between the four concentrations, where the highest mortality was recorded after 120 h. On the adults (85%). Treatment with the titanium dioxide nanoparticles inhibited the activities of acetylcholine esterase and total soluble protein. While it increases the activity of catalase as antioxidant enzyme. Nutritional values increased with increasing the proportion of TiO2 NPs, except for the decrease in protein. No colonization of coliform bacteria and fungi cell was recorded in 80% of TiO2 NPs, aerobic bacteria were reduced to a lower number 12 CFU/g 103 at 100%. Biosynthesized titanium dioxide nanoparticles with J. phoenicea extract is promising bio-insecticide and antimicrobial in integrated pest management control, preserving the nutritional value of grains during storage.
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K J, Mangala. "Green synthesis of titanium dioxide nanoparticles using Thymus vulgaris leaf extract for biological applications." Advances in Natural Sciences: Nanoscience and Nanotechnology 14, no. 3 (2023): 035016. http://dx.doi.org/10.1088/2043-6262/acf2ed.
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Abstract In the last few decades, the biosynthesis of nanoparticles using biological agents such as microorganisms or plant extracts has gained a lot of attention due to the growing need for generating safe and non-toxic substances, cost-effective techniques, ecologically friendly solvents, and renewable materials. The aqueous leaf extract of Thymus vulgaris was used in the current investigation to achieve the biosynthesis of TiO2 nanoparticles (TiO2 NPs). In this study, leaf extract was used as a size-reducer in synthesis of TiO2. Thyme leaf extract contains flavonoids, phenols, and saponins, which function as both reducing and stabilising agents and are crucial for the synthesis of TiO2 nanoparticles. Methods such as Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible diffuse reflectance spectroscopy (UV-DRS), x-ray diffraction (XRD), photoluminescence (PL), and scanning electron microscopy (SEM) with energy dispersive x-ray (EDX) were used to characterise TiO2 NPs. The XRD investigations showed that titanium dioxide nanoparticles are crystalline and average crystal size is 28 nm. Gram-positive bacteria like S. aureus and B. subtilis as well as Gram-negative bacteria like Pseudomonas aeruginosa were used as standardised test microbial inoculums to evaluate the antibacterial properties of biosynthesised nanoparticles (TiO2 NPs). Against each of the studied bacteria, the TiO2 nanoparticles demonstrated significant antimicrobial activity. TiO2 nanoparticles had the maximum activity against Staphylococcus aureus, with an inhibitory zone diameter of 14 mm at 100 g ml−1. By using DPPH, hydroxyl radical techniques, the comprehensive antioxidant activity of produced NPs was examined.
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Kassalia, Maria-Emmanouela, Nikos Chorianopoulos, George-John Nychas, and Evangelia A. Pavlatou. "Investigation of the Photoinduced Antimicrobial Properties of N-Doped TiO2 Nanoparticles under Visible-Light Irradiation on Salmonella Typhimurium Biofilm." Applied Sciences 13, no. 7 (2023): 4498. http://dx.doi.org/10.3390/app13074498.
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The aim of the present study was to investigate the photoinduced properties of nitrogen-doped titanium dioxide (N-TiO2) against the Salmonella ser. Typhimurium bacterial biofilm, under visible-light irradiation. The capability of N-TiO2 nanoparticles working as multipurpose materials with antimicrobial applications, as well as environmental ones, was therefore investigated. The sol–gel method was used to synthesize N-TiO2 particles, which were then characterized by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET) analysis of surface area, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), and transmission electron microscopy (TEM). The results showed that the particles formed were nano-sized and had the expected Ti-O bonds and the presence of elemental N. The as-produced N-TiO2 nanoparticles (NPs) were tested for their antimicrobial activity. The antibacterial photocatalytic testing was performed under visible-light irradiation, on Salmonella Typhimurium biofilm. To form the biofilm, stainless steel (ss) coupons were incubated with three different strains of Salmonella Typhimurium bacteria for 48 h at 15 °C in tryptone soy broth (TSB). After the biofilm’s formation, the coupons were placed on a horizontal, rectangular, batch, equipped with a vis-LED irradiation source reactor in the presence of N-TiO2 NPs. After 1, 2, and 3 h of irradiation, sampling of the bacterial population was assessed. The results showed an evident inhibition of proliferation under light irradiation when the N-TiO2 was present, compared to the non-irradiated NPs. It is noteworthy that, during the first 2 h, the TiO2 NPs specimens tended to attract more bacteria on their surface then the control specimens, due to their higher available surface area, which worked as a shelter. There were ~6% viable (remaining) Salmonella cells after the first hour of visible-light irradiation with N-TiO2 NPs.
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Samb-Joshi, Kanchan M., Yogesh A. Sethi, Anuradha A. Ambalkar, et al. "Lignin-Mediated Biosynthesis of ZnO and TiO2 Nanocomposites for Enhanced Antimicrobial Activity." Journal of Composites Science 3, no. 3 (2019): 90. http://dx.doi.org/10.3390/jcs3030090.
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In this work, we report the synthesis of fragmented lignin (FL) assisted zinc oxide (ZnO) and titanium oxide (TiO2) nanocomposites. The fragmented lignin synthesized from biomass (sugarcane bagasse) was used as a template to generate the morphology and crystallite structure of metal oxide nanomaterial. The nanocomposites were synthesized by a simple precipitation method, wherein fragmented lignin is used in alkaline medium as a template. X-ray diffraction (XRD) analysis shows the phase formation of hexagonal wurtzite ZnO and mixed phase formation of TiO2 as rutile and anatase. The morphology was studied by using field emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HRTEM). The FE-SEM of pristine ZnO nanocomposites showed a cluster of particles whereas FL–ZnO NPs showed self-aligned nanoparticles in the form of rod shaped having average size 30–70 nm. Pristine TiO2 nanoparticles showed clusters of particles and FL–TiO2 nanocomposites showed well crystalline 41nm size nanocomposites. The FL acts as a surfactant which restrict the cluster formations. The band gap determined by diffuse reflectance spectra is 3.10 eV and 3.20 eV for FL–ZnO and FL–TiO2 nanocomposites, respectively. Photoluminescence spectra of both nanocomposites showed structural defects in the visible region. Further, the antimicrobial activity of pristine ZnO and TiO2 nanoparticles, and FL–ZnO and FL–TiO2 nanocomposites against Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC25923) were studied under UV-A (315-400 nm) (8W) for 30min.
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Hassan, H., K. I. Omoniyi, F. G. Okibe, A. A. Nuhu, and E. G. Echioba. "Assessment of Wound Healing Activity of Green Synthesized Titanium Oxide Nanoparticles using Strychnos spinosa and Blighia sapida." Journal of Applied Sciences and Environmental Management 24, no. 2 (2020): 197–206. http://dx.doi.org/10.4314/jasem.v24i2.2.
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The biosynthesis of nanoparticles has been proposed as a cost effective and environmentally friendly alternative to chemical and physical methods. The present work investigates the synthesis of titanium oxide nanoparticles (TiO2 NPs) by green approach using Strychnos spinosa and Blighia sapida leave extracts. The detailed characterization of the TiO2 NPs was carried out using UV-Visible Spectroscopy, Scanning Electron Microscopy (SEM), X- ray Diffraction (XRD), and Fourier-Transform Infrared (FTIR) Spectroscopy. The green synthesized TiO2 NPs excitation was confirmed using UV–Vis spectrophotometer at 270 and 290 nm for Strychnos spinosa and Blighia sapida respectively. SEM revealed that the synthesized TiO2 NPs were spherical and crystalline in nature. The overall sizes are 40 and 50 nm for Strychnos spinosa and Blighia sapida respectively. FTIR spectroscopic analysisshowed the presence of flavonoids, polyphenols and amide groups likely to be responsible for the green synthesis of titanium oxide nanoparticles using S. Spinosa and B .sapida aqueous leaf extracts. The XRD pattern showed the characteristic Bragg peaks of (111), (200), (220) and (311) facets of the anatase titanium oxide nanoparticles and confirmed that these nanoparticles were crystalline and spherical in nature. Furthermore, the green synthesized TiO2 NPs wound healing activity was examined in the excision wound model by measuring wound closure, histopathology and protein profiling. This revealed significant wound healing activity in Albino rats. In the present study, topical application ofnanoformulated extracts of B. sapidaa nd S. spinosa significantly accelerated wound healing with 20% nanoformulated ointment having the highest percentage wound contraction ability comparable with gentamicin (a commercially sold antimicrobial agent used in dressing wounds). In conclusion, this work proved the capability of using TiO2 NPs to deliver a novel therapeutic route for wound treatment in clinical practice.
 Keywords: Wound healing activity; SEM; TiO2; XRD; FTIR; UV–Vis spectroscopy.
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Gordillo-Delgado, Fernando, Jakeline Zuluaga-Acosta, and Gonzalo Restrepo-Guerrero. "Effect of the suspension of Ag-incorporated TiO2 nanoparticles (Ag-TiO2 NPs) on certain growth, physiology and phytotoxicity parameters in spinach seedlings." PLOS ONE 15, no. 12 (2020): e0244511. http://dx.doi.org/10.1371/journal.pone.0244511.
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In this work, the effect of the inoculation of silver-incorporated titanium dioxide nanoparticles (Ag-TiO2 NPs) in spinach seeds was evaluated on certain growth, physiology and phytotoxicity parameters of the plants. This is an important crop for human consumption with high nutritional value due to their low calorie and fat content, providing various vitamins and minerals, especially iron. These NPs were obtained by means of the sol-gel method and heat treatment; the resulting powder material was characterized using X-ray diffraction and scanning electron microscopy and the influence of these NPs on plants was measured by estimating the germination rate, monitoring morphological parameters and evaluating phytotoxicity. The photosynthetic activity of the spinach plants was estimated through the quantification of the Ratio of Oxygen Evolution (ROE) by the photoacoustic technique. Samples of TiO2 powder with particle size between 9 and 43 nm were used to quantify the germination rate, which served to determine a narrower size range between 7 and 26 nm in the experiments with Ag-TiO2 NPs; the presence of Ag in TiO2 powder samples was confirmed by energy-dispersive X-ray spectroscopy. The analysis of variance showed that the dependent variable (plant growth) could be affected by the evaluated factors (concentration and size) with significant differences. The statistical trend indicated that the application of the Ag-TiO2 NPs suspension of lowest concentration and smallest particle size could be a promoting agent of the growth and development of these plants. The inoculation with NPs of 8.3 nm size and lowest concentration was related to the highest average ROE value, 24.6 ± 0.2%, while the control group was 20.2 ± 0.2%. The positive effect of the Ag-TiO2 NPs treatment could be associated to the generation of reactive oxygen species, antimicrobial activity, increased biochemical attributes, enzymatic activity or improvements in water absorption.
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Schneider, György, Bettina Schweitzer, Anita Steinbach, Botond Zsombor Pertics, Alysia Cox, and László Kőrösi. "Antimicrobial Efficacy and Spectrum of Phosphorous-Fluorine Co-Doped TiO2 Nanoparticles on the Foodborne Pathogenic Bacteria Campylobacter jejuni, Salmonella Typhimurium, Enterohaemorrhagic E. coli, Yersinia enterocolitica, Shewanella putrefaciens, Listeria monocytogenes and Staphylococcus aureus." Foods 10, no. 8 (2021): 1786. http://dx.doi.org/10.3390/foods10081786.
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Contamination of meats and meat products with foodborne pathogenic bacteria raises serious safety issues in the food industry. The antibacterial activities of phosphorous-fluorine co-doped TiO2 nanoparticles (PF-TiO2) were investigated against seven foodborne pathogenic bacteria: Campylobacter jejuni, Salmonella Typhimurium, Enterohaemorrhagic E. coli, Yersinia enterocolitica, Shewanella putrefaciens, Listeria monocytogenes and Staphylococcus aureus. PF-TiO2 NPs were synthesized hydrothermally at 250 °C for 1, 3, 6 or 12 h, and then tested at three different concentrations (500 μg/mL, 100 μg/mL, 20 μg/mL) for the inactivation of foodborne bacteria under UVA irradiation, daylight exposure or dark conditions. The antibacterial efficacies were compared after 30 min of exposure to light. Distinct differences in the antibacterial activities of the PF-TiO2 NPs, and the susceptibilities of tested foodborne pathogenic bacterium species were found. PF-TiO2/3 h and PF-TiO2/6 h showed the highest antibacterial activity by decreasing the living bacterial cell number from ~106 by ~5 log (L. monocytogenes), ~4 log (EHEC), ~3 log (Y. enterolcolitca, S. putrefaciens) and ~2.5 log (S. aureus), along with complete eradication of C. jejuni and S. Typhimurium. Efficacy of PF-TiO2/1 h and PF-TiO2/12 h NPs was lower, typically causing a ~2–4 log decrease in colony forming units depending on the tested bacterium while the effect of PF-TiO2/0 h was comparable to P25 TiO2, a commercial TiO2 with high photocatalytic activity. Our results show that PF-co-doping of TiO2 NPs enhanced the antibacterial action against foodborne pathogenic bacteria and are potential candidates for use in the food industry as active surface components, potentially contributing to the production of meats that are safe for consumption.
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Harsha, L., and Aravind Subramanian. "An In Vitro Evaluation of The Effect of Titanium Dioxide Nanoparticle on The Shear Bond Strength and Antimicrobial Property of Orthodontic Adhesive: A Systematic Review and Meta-Analysis." Journal of Complementary Medicine Research 13, no. 5 (2022): 105. http://dx.doi.org/10.5455/jcmr.2022.13.05.20.
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Objective: The objective of this review was to systematically analyse available literature on the effects of titanium dioxide nanoparticles (TiO₂ NPs) in improving the antimicrobial activity and shear bond strength when incorporated in orthodontic adhesives. Methods: All invitro studies that have evaluated the shear bond strength and the antimicrobial activity of TiO2 NPs infiltrated orthodontic adhesive were included in this review. A comprehensive search in 5 electronic databases namely, Google scholar, PUBMED, EMBASE, Cochrane and Web of science were done up to January 2023. Using the reference method for invitro studies, the Risk of bias ROB was evaluated. Meta-analysis using Random Effects Model was performed for assessing the antimicrobial activity against S. mutans, C. albicans and L. Acidophilus. Results: All the included studies had a moderate risk of bias. On qualitative analysis, a significant antimicrobial effect against Streptococcus mutans and Lactobacillus acidophilus and a non-significant shear bond strength of TiO2 infiltrated orthodontic adhesive was reported. The meta-analysis revealed a significant overall antimicrobial effect and non-significant shear bond strength values with a high heterogeneity. Conclusion: An overall significant antimicrobial effect of TiO₂ infiltrated orthodontic adhesive against S. mutans and L. Acidophilus was noted but with a high heterogeneity and a moderate risk of bias. An overall non-significant shear bond strength of TiO₂ infiltrated orthodontic adhesive was noted but with a high heterogeneity and a moderate risk of bias.
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Ben Chobba, Marwa, Maduka L. Weththimuni, Mouna Messaoud, et al. "Silver-Doped TiO2-PDMS Nanocomposite as a Possible Coating for the Preservation of Serena Stone: Searching for Optimal Application Conditions." Heritage 5, no. 4 (2022): 3411–26. http://dx.doi.org/10.3390/heritage5040175.
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The main objective of this research is to determine the optimal application conditions of a newly synthesized multifunctional coating containing Ag-doped TiO2 nanoparticles when used as a possible protective agent for sandstone. Firstly, Ag-TiO2 nanoparticles with anatase structure, spherical shape and controllable sizes were prepared using the sol–gel method and characterized. The biocidal activity of Ag-doped TiO2 NPs was studied by comparing its performance to pure TiO2 NPs against two representative Gram-positive and Gram-negative bacterial strains, under both visible irradiation and in the dark; then, the antimicrobial efficiency of two different concentrations of Ag-TiO2 nanoparticles (0.1–1 mol%) was evaluated against two phototrophic strains commonly isolated from deteriorated surfaces. Results showed that the photoactivation and photokilling activity of TiO2 were highly improved by doping with Ag. Next, prepared nanopowders were dispersed in a binder with different powder/PDMS ratios: (0.1, 0.2, 0.5 and 1% w/v TiO2) and then applied in different amounts (2, 3 and 6 g/m2) on Serena stone specimens. Results revealed that the application of 2 g/m2 nanocomposite at powder/binder ratios equal to 1% w/v TiO2 provided a fine hydrophobic character for the stone material with acceptable chromatic variations.
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Bottagisio, Marta, Arianna Lovati, Fabio Galbusera, Lorenzo Drago, and Giuseppe Banfi. "A Precautionary Approach to Guide the Use of Transition Metal-Based Nanotechnology to Prevent Orthopedic Infections." Materials 12, no. 2 (2019): 314. http://dx.doi.org/10.3390/ma12020314.
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The increase of multidrug-resistant bacteria remains a global concern. Among the proposed strategies, the use of nanoparticles (NPs) alone or associated with orthopedic implants represents a promising solution. NPs are well-known for their antimicrobial effects, induced by their size, shape, charge, concentration and reactive oxygen species (ROS) generation. However, this non-specific cytotoxic potential is a powerful weapon effective against almost all microorganisms, but also against eukaryotic cells, raising concerns related to their safe use. Among the analyzed transition metals, silver is the most investigated element due to its antimicrobial properties per se or as NPs; however, its toxicity raises questions about its biosafety. Even though it has milder antimicrobial and cytotoxic activity, TiO2 needs to be exposed to UV light to be activated, thus limiting its use conjugated to orthopedic devices. By contrast, gold has a good balance between antimicrobial activity as an NP and cytocompatibility because of its inability to generate ROS. Nevertheless, although the toxicity and persistence of NPs within filter organs are not well verified, nowadays, several basic research on NP development and potential uses as antimicrobial weapons is reported, overemphasizing NPs potentialities, but without any existing potential of translation in clinics. This analysis cautions readers with respect to regulation in advancing the development and use of NPs. Hopefully, future works in vivo and clinical trials will support and regulate the use of nano-coatings to guarantee safer use of this promising approach against antibiotic-resistant microorganisms.
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Tortella, Gonzalo, Olga Rubilar, Paola Fincheira, et al. "Bactericidal and Virucidal Activities of Biogenic Metal-Based Nanoparticles: Advances and Perspectives." Antibiotics 10, no. 7 (2021): 783. http://dx.doi.org/10.3390/antibiotics10070783.
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Much progress has been achieved in the preparation and application of engineered nanoparticles (NPs) in the field of medicine, mainly for antibacterial and antiviral applications. In the war against bacteria and viruses, besides traditional antibiotics and antiviral drugs, metal-based nanoparticles, such as silver (AgNPs), copper (CuNPs), copper oxides (CuO-NPs), iron oxide (FeO-NPs), zinc oxide (ZnO-NPs), and titanium oxide (TiO2-NPs) have been used as potent antimicrobial agents. These nanoparticles can be synthesized by traditional methods, such as chemical and physical routes, or more recently by biogenic processes. A great variety of macro and microorganisms can be successfully used as reducing agents of metal salt precursors in the biogenic synthesis of metal-based NPs for antimicrobial activity. Depending on the nature of the biological agent, NPs with different sizes, aggregation states, morphology, surface coatings and charges can be obtained, leading to different antimicrobial effects. Considering the drug resistance to traditional therapies, the development of versatile nanomaterials with potent antimicrobial effects is under intensive investigation. In this sense, this review presents and discusses the recent progress in the preparation and application of metal-based nanoparticles biogenically synthesized for antibacterial and antivirus applications. The strength and limitations are critically discussed.
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Nayak1, Heena, and Pragya Kulkarni. "Industrial algae mediated development and evaluation of Titanium Oxide nanoparticles, their ability to fight bacteria, and environmental application." Spectrum of Emerging Sciences 4, no. 1 (2024): 7–12. http://dx.doi.org/10.55878/ses2024-4-1-2.
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The field of nanotechnology is rapidly growing and has a wide range of application in medical science, engineering, pharmacy, and other disciplines. In the present day the world is facing the major problems of water pollution and health issues. The Industrial algae extract and Titanium is opropoxide was used for the eco-friendly synthesis of the NPs consisting of TiO2 effect of TiO2 small particles against polluted water were tested and its antimicrobial properties are observed. The synthesized particles were distinguished by the Spectrophotometer UV-visible, Infrared Fourier Transform Spectroscopy (FT-IR), XRD, Antimicrobial study. Further prepared materials were used for methylene blue dye reduction and antibacterial activity was done on Staphylobacillus.
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Alsalih, Moatasem Wdaah, Syakirah Samsudin, and Siti Suri Arshad. "Ma Synthesis and characterizations Titanium Dioxide Nanocomposite by Laser Ablation for Antimicrobial Applications." Science Proceedings Series 1, no. 3 (2019): 26–29. http://dx.doi.org/10.31580/sps.v1i3.886.
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Background: a composite nanoparticles containing Titanium Dioxide are synthesized by pulsed laser ablation. oxide nanoparticles NPs have wide ranges of physical, chemical and biological properties. The main advantages In the present work, studying the characterization of colloid TiO2 NPs were synthesis by PLAL and investigated the antibacterial activity of colloidal TiO2NPs compared to the antibacterial activity of synthesized composite nanoparticles was tested against four different pathogen bacteria two-gram negative (Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae )), institute of bioscience UPM university kindly supplied these bacteria. The bacterial suspension was made and adjusted by comparison against 0.5 Mc-Farland turbidity typical (5x 107cell ml-1) tubes. It was further diluted to obtain a final of 5 x 106cell ml-1. All bacteria strains were culture in agar media. The media was inoculated by the 0.2 ml/5ml with either the bacteria strains, then added 0.5 ml of TiO2 nanoparticles at concentration200, 400,600 ml-1. The samples were incubated at 37 °C. The bacterial growth was measured by optical density that absorbs strongly at 532 nm wavelength. Conclusion that is the mean values of inhibition were calculated from triple evaluation in each assessment.
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Meleshko, А. A., A. G. Afinogenova, G. E. Afinogenov, A. A. Spiridonova та V. P. Tolstoy. "Аntibacterial inorganic agents: efficiency of using multicomponent systems". Russian Journal of Infection and Immunity 10, № 4 (2020): 639–54. http://dx.doi.org/10.15789/2220-7619-aia-1512.
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Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents. They have a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans. The use of NPs reduces the possibility of the microbial resistance development. This review briefly shows the general mechanisms and the main factors of antibacterial activity of NPs. In this article, a comprehensive review of the recent researches in the field of new antimicrobial agents with superior long-term bactericidal activity and low toxicity is provided. The review gives the examples of synthesis of double and triple nanocomposites based on following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2, etc. including metal and nonmetal doped nanocomposites (for example with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F, etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and have synergistic effects. For example, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by -100% by formation of triple nanocomposites ZnO—MnO2—Cu2O or ZnO—Ag2O—Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. The present article also provides the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers, etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and longterm antibacterial activity. All of the considered nanocomposites and their combinations have a pronounced long-term antimicrobial effect including against antibiotic-resistant strains. They are able to prevent the formation of microbial biofilms on biotic and abiotic surfaces, have low toxicity to eukaryotic cells, demonstrate anti-inflammatory and woundhealing properties in compositions with polymers (sodium alginate, collagen, polyvinylpyrrolidone, etc.). The use of nanoscale systems can solve several important practical problems at the same time: saving of long-term antimicrobial activities while reducing the number of compounds, creation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.
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A., Shalini Krubha, and Velmurugan S. "Pharmacological Applications of Iron Doped Titanium Oxide (Fe/TiO2) Nanoparticles Derived from Beta vulgaris Leaf Extract." Indian Journal of Science and Technology 18, no. 18 (2025): 1430–40. https://doi.org/10.17485/IJST/v18i18.153.
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Abstract <strong>Objectives:</strong> To evaluate the structural, morphological and pharmacological application of green synthesized iron doped titanium oxide nanoparticles derived from Beta vulgaris leaves extract. <strong>Methods:</strong> A green synthesis of Fe doped TiO2 a nanoparticle (Fe/TiO2) was achieved using aqueous extract of Beta vulgaris leaves. The obtained Fe/TiO2 was categorized by analytical techniques including UV, FTIR, XRD, SEM, EDS and TEM. Antibacterial and antifungal activities were analyzed by PDA agar disc diffusion method, while the anticancer studies were carried out using MCF-7 cell-line by MTT assay method. <strong>Findings:</strong> The FTIR spectrum haves showed a new broad band at 574 cm-1 indicating to TiO2 with ferrous ion. The UV spectrum shows absorption peaks at 277.40, 396.30 and 453.30 nm, which tallies with the wavelength of the surface plasmon resonance (SPR) of Fe/TiO2 bimetallic NPs. The XRD peaks corresponding to rutile phase also emerged at 2 = 25.61(121) and 39.69 (004) diffraction corresponding to the Fe3+ ions could substitute Ti4+ from some of the lattice sites of TiO2. SEM, EDS and TEM images have showed very clear shapes of ferrous ion anatase, Antibacterial activity of green synthesized Fe/TiO2 has excellent zone of inhibition (14 mm) which is appreciable. Anticancer activities have showed significant effects (IC50= 62.5 μg/m.L). <strong>Novelty:</strong> The nanoparticles of Fe/TiO2 mediated by Beta vulgaris have acted as effective bioreductant and also as potential anticancer agent. <strong>Keywords:</strong> Green synthesis, Beta vulgaris, Fe/TiO2NPs, Antimicrobial, Antioxidant, Anticancer activity
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Metryka, Oliwia, Daniel Wasilkowski, and Agnieszka Mrozik. "Insight into the Antibacterial Activity of Selected Metal Nanoparticles and Alterations within the Antioxidant Defence System in Escherichia coli, Bacillus cereus and Staphylococcus epidermidis." International Journal of Molecular Sciences 22, no. 21 (2021): 11811. http://dx.doi.org/10.3390/ijms222111811.
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The antimicrobial activity of nanoparticles (NPs) is a desirable feature of various products but can become problematic when NPs are released into different ecosystems, potentially endangering living microorganisms. Although there is an abundance of advanced studies on the toxicity and biological activity of NPs on microorganisms, the information regarding their detailed interactions with microbial cells and the induction of oxidative stress remains incomplete. Therefore, this work aimed to develop accurate oxidation stress profiles of Escherichia coli, Bacillus cereus and Staphylococcus epidermidis strains treated with commercial Ag-NPs, Cu-NPs, ZnO-NPs and TiO2-NPs. The methodology used included the following determinations: toxicological parameters, reactive oxygen species (ROS), antioxidant enzymes and dehydrogenases, reduced glutathione, oxidatively modified proteins and lipid peroxidation. The toxicological studies revealed that E. coli was most sensitive to NPs than B. cereus and S. epidermidis. Moreover, NPs induced the generation of specific ROS in bacterial cells, causing an increase in their concentration, which further resulted in alterations in the activity of the antioxidant defence system and protein oxidation. Significant changes in dehydrogenases activity and elevated lipid peroxidation indicated a negative effect of NPs on bacterial outer layers and respiratory activity. In general, NPs were characterised by very specific nano-bio effects, depending on their physicochemical properties and the species of microorganism.
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H. Abbas, Ruaa, Azhar M. Haleem, Mazin K. Hamid, A. Kadhim, and Raad S. Jawad. "Antimicrobial Activity of TiO2 NPs against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923." International Journal of Computation and Applied Sciences 2, no. 1 (2017): 6–10. http://dx.doi.org/10.24842/1611/0017.
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