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Dissertations / Theses on the topic 'Antimicrobial metabolites'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Ali, Marina, University of Western Sydney, and School of Civic Engineering and Environment. "Antimicrobial metabolites from Australian Acacia." THESIS_XXXX_CEE_Ali_M.xml, 1998. http://handle.uws.edu.au:8081/1959.7/216.

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As part of an investigation into traditional Australian Aboriginal bush medicine a range of Acacia species have been examined. Several species have been reported to be utilised for the preparation of antimicrobial washes and lotions by Aboriginal tribes. Initial bioactivity screening focussed on antimicrobial activity of the polar/and or non-polar extracts of air dried plant material, and a range of interesting activity has been found. Specifically, of the 94 extracts of Acacia species screened, five showed activity against the fungus C.albicans, 47 showed activity showed activity against the

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2

Ali, Marina. "Antimicrobial metabolites from Australian Acacia." Thesis, View thesis, 1998. http://handle.uws.edu.au:8081/1959.7/216.

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As part of an investigation into traditional Australian Aboriginal bush medicine a range of Acacia species have been examined. Several species have been reported to be utilised for the preparation of antimicrobial washes and lotions by Aboriginal tribes. Initial bioactivity screening focussed on antimicrobial activity of the polar/and or non-polar extracts of air dried plant material, and a range of interesting activity has been found. Specifically, of the 94 extracts of Acacia species screened, five showed activity against the fungus C.albicans, 47 showed activity showed activity against the

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3

Ali, Marina. "Antimicrobial metabolites from Australian Acacia : thesis /." View thesis, 1998. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030825.144902/index.html.

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4

AISSANI, NADHEM. "Nematicidal, antimicrobial and acaricidal activity of plant secondary metabolites." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266458.

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Numerous research studies are focused on the isolation and identification of new active compounds derived from plants. In this PhD thesis we report for the first time about the use of Ailanthus altissima, Capparis spinosa, Melia azedarach and Armoracia rusticana and their secondary metabolites such as α, β- and α, β, γ, δ- unsaturated aldehydes, isothiocyanates and polyphenols as potential nematicidal against the root knot nematode Meloidogyne spp. We deal also about the possible mode of action of aromatic aldehydes by the inhibition of V-ATPase of the nematode. Second, we demostrate the anti

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5

Yaipakdee, Panadda. "Secondary metabolites of Aspergillus Candidus :|bisolation, chemical, antimicrobial and biotransformation studies /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu148795121493887.

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6

Sweidan, Alaa. "Antibiofilm activity of lichen secondary metabolites." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B017/document.

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Les bactéries buccales n'infectent pas seulement la bouche mais y resident. Elles peuvent également passer dans la voie sanguine et atteindre des organes secondaires. S’il n'est pas traité, le biofilm dentaire peut provoquer une inflammation destructrice dans la cavité buccale, entrainant de graves complications médicales. Dans ce biofilm, Streptococcus gordonii, colonisateur oral primaire, constitue la plate-forme sur laquelle des colonisateurs pathogènes tardifs comme Porphyromonas gingivalis, l'agent causal des maladies parodontales, se lieront. L'objectif de la première partie de la thèse

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7

Mann, Maryssa Gudrun Ailsa. "An investigation of the antimicrobial and antifouling properties of marine algal metabolites." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1007465.

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Prevention of the accumulation of undesirable biological material i.e. biofouling upon a solid surface requires the use of antifouling systems. The solid surface may be a contact lens, an off shore oil rig or a living organism. When chemicals are employed as a mechanism of defense against biofouling, the agents involved are known as antifouling agents. Marine algae must protect themselves from fouling organisms and it is thought that one of the mechanisms used by these organisms is the production of secondary metabolites with an array of biological activities. In vitro studies have shown numer

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Rojas, Rosario. "Secondary metabolites of Vernonia gigantea roots : isolation, antimicrobial, chemical and biotransformation studies." Connect to resource, 2000. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1228166792.

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9

Desai, Prerak T. "Antimicrobial Properties of Syringopeptin 25A and Rhamnolipids." DigitalCommons@USU, 2006. https://digitalcommons.usu.edu/etd/5526.

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The increasing bacterial resistance to available antibiotics requires the search for new antibacterial compounds to be broadened. This study investigated the antimicrobial properties of two secondary metabolites from fluorescent pseudo monads -- syringopeptin 25A, a lipodepsipeptide produced by Pseudomonas syringae pv. syringae, and a rhamnolipid mixture produced by Pseudomonas aeruginosa. The rate of antimicrobial action was determined by monitoring the rate of uptake of propidium iodide during exposure to the compounds. Inhibition was also confirmed by the microbroth dilution method to deter

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Sequeira, Patrícia Alexandra Soares. "Elucidate the biosy nthesis and the functional role of a new class of antimicrobial peptaibiotics in Neurospora crassa." Master's thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2017. http://hdl.handle.net/10362/79298.

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"Fungi are generally abundant producers of secondary metabolites. In particular, these organisms are involved in the production of a subclass of nonribosomal peptides - peptaibiotics - which display interesting antibiotic activities. Previous studies demonstrated that some fungal strains are able to grow in media supplemented with ionic liquid and this supplementation leads to alterations in their metabolic footprint. Moreover, in Neurospora crassa, growth media supplementation with either 1-ethyl-3-methylimidazolium chloride or cholinium chloride, led to increased levels of 1-aminocyclopropan

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11

Griffin, Shane G., of Western Sydney Hawkesbury University, and of Science Technology and Agriculture Faculty. "Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure." THESIS_FSTA_XXX_Griffin_S.xml, 2000. http://handle.uws.edu.au:8081/1959.7/243.

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Although the antomicrobial nature of essential oils and their major constituents, the terpenoids, has been widely investigated the mechanism of their antimicrobial action has not been subject to the same scrutiny. In this study the membrane disruptive nature of the terpenoids has been determined by experiments on the effects of terpenes on both microbial membrane and model lipid bilayer systems. These terpenes exhibited a range of membrane damaging effects. Experiments showed that the terpenoids were able to increase disorder in DPPC bilayers, and that antimicrobially active terpenoids cause i

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12

Guedes, Vanessa Rodrigues. "Estudo das atividades antimicrobianas dos extratos dos fungos Moniliophthora perniciosa, Phytophthora palmivora, Trichoderma stromaticum e Xylaria spp., e estudo químico de exemplares de Xylaria spp." reponame:Repositório Institucional da UFBA, 2011. http://www.repositorio.ufba.br/ri/handle/ri/10057.

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274f.<br>Submitted by Ana Hilda Fonseca (anahilda@ufba.br) on 2013-04-03T15:45:11Z No. of bitstreams: 1 Tese Vanessa R Guedes.pdf: 23534749 bytes, checksum: df0c04b0207f9bf62a0952e36a12f3f8 (MD5)<br>Approved for entry into archive by Ana Hilda Fonseca(anahilda@ufba.br) on 2013-04-23T16:58:28Z (GMT) No. of bitstreams: 1 Tese Vanessa R Guedes.pdf: 23534749 bytes, checksum: df0c04b0207f9bf62a0952e36a12f3f8 (MD5)<br>Made available in DSpace on 2013-04-23T16:58:28Z (GMT). No. of bitstreams: 1 Tese Vanessa R Guedes.pdf: 23534749 bytes, checksum: df0c04b0207f9bf62a0952e36a12f3f8 (MD5) Previous

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Caruso, Andrea. "Phenotypic and transcriptional analysis of secondary metabolites production in Pseudomonas corrugata CFBP5454." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/3787.

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Natural products have received a great deal of attention as sustainable alternative for management of plant diseases. In this study the potential and actual arsenal of secondary antimicrobial metabolites of the bacterium Pseudomonas corrugata, an ubiquitous bacterium, was dissected by phenotypic assays, genome mining and transcriptional studies. Pseudomonas corrugata strain CFBP 5454 was shown to produce diffusible compounds that inhibit the growth of plant pathogenic fungi and bacteria and antifungal volatile compounds and to produce cyanide. Mutant derivatives in LuxR transcriptional regulat

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Fernandes, Tanize Stuker. "Analise fitoquímica de duas espécies de rutaceae: Helietta apiculata benth e zanthoxylum fagara (l.) Sarg." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/4280.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The phytochemical investigation of methanol crude extract of the stem bark of the species Helietta apiculata Benth and Zanthoxylum fagara (L.) Sarg., Rutaceae, provided the isolation of thirty-one compounds. The species H. apiculata were isolated eight furoquinolínicos alkaloids (8, 9, 10, 11, 12, 13, 15 and 24) and one quinolinone (22), six coumarins (51, 52, 53, 58, 115 and 116), 116 first identified in the literature, three cinnamates (121, 122 and 123), two lignans (98 and 123), a limonoid (92), a long-chain acid (126), a ste

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15

Svahn, Stefan. "Analysis of Secondary Metabolites from Aspergillus fumigatus and Penicillium nalgiovense : Antimicrobial Compounds from Filamentous Fungi Isolated from Extreme Environments." Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242611.

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This thesis describes the cultivation and extraction of filamentous fungi isolated from extreme environments in the search for new antibiotic compounds. Filamentous fungi are a rich source of medicines including antibiotics, and it is believed that many currently unknown fungal species and bioactive fungal metabolites remain to be discovered. Aspergillus fumigatus and Penicillium nalgiovense strains were isolated from an antibiotic-contaminated riverbed near Hyderabad, India, and soil taken from a penguin’s nest on Paulete Island, Antarctica, respectively. It was anticipated that the extreme c

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Griffin, Shane. "Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure /." View thesis View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030429.142248/index.html.

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17

Tawfike, Ahmed. "Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search for new potential anti-cancer and antimicrobial drugs." Thesis, University of Strathclyde, 2015. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25719.

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Endophytes are microbes that inhabit living, internal tissues of plants without causing any immediate, apparent negative effects. Endophytic fungi associated with medicinal plants represent a potential source of novel chemistry and biology. This study involved isolation of three endophytic fungal strains from two Egyptian medicinal plants, Terminalia laxiflora and Markhamia platicalyx. Identification of the strains has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liqui

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18

Santos, Daniele Damian dos. "CONTROLE DE QUALIDADE, ANÁLISE FITOQUÍMICA E ATIVIDADE ANTIMICROBIANA DE Bidens pilosa LINNAEUS (ASTERACEAE)." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4898.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The use of natural resources as a treatment and cure of diseases is an old and still widely used method. The study aims to determine the antimicrobial activity and secondary metabolites from plants Bidens pilosa L. obtained in different crops as well as perform the physical-chemical quality control of plant drug. Studying the in vitro germination were tested different conditions and diasporas storage periods, and the ex vitro different substrate preparation. In micropropagation, they were used apical segments and nodal, and combina

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19

Camillo, Ana Silvia Ciscato. "Otimização das condições de cultivo de 'Rhizopus microsporus' var. 'rhizopodiformis' para a produção, isolamento e identificação de metabólitos com atividade antimicrobiana." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-03082007-103314/.

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O fungo Rhizopus microsporus var. rhizopodiformis foi submetido a determinadas condições de cultivo, objetivando produzir substâncias com atividade antimicrobiana. O microorganismo foi transferido da sílica, na qual foi armazenado, e incubado por sete dias em meio aveia-ágar para o crescimento prévio. Em seguida, 4 x 106 esporos/mL de meio foram transferidos para o meio pré-fermentativo e incubado por 24 horas, seguido de transferência para meio fermentativo (meio Czapek, meio Jackson e meio Vogel) e incubado por períodos de tempo determinados. Além disso, foi incubado em meio fermentativo de

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Chan, Andrea C. "The application of nanomaterials for the delivery of natural antimicrobials in engineered systems." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:9f8b7c1c-7d49-437b-9743-cb3008d89f86.

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Biofouling is the undesired biofilm formation on surfaces at a liquid interface that interferes with the affected substrate’s function. It is a ubiquitous problem in many engineered systems in industry. Biofouling causes contamination, essential damage to materials, and impedances to crucial industrial processes. These adverse effects lead to health hazards, gross increase in energy consumption, and significant decrease in overall productivity, all of which result in higher operational costs and environmentally destructive consequences. Interest in discovering effective alternatives to convent

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Tabares, Paula [Verfasser], and Ute [Akademischer Betreuer] Hentschel. "Antimicrobial, anti-protease and immunomodulatory activities of secondary metabolites from Caribbean sponges and their associated bacteria = Sekundärmetabolite mit antimikrobiellen, Protease-hemmenden und immunmodulatorischen Aktivitäten aus karibischen Schwämmen und assoziierten Bakterien / Paula Tabares. Betreuer: Ute Hentschel." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1018612874/34.

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22

Sanja, Vlaisavljević. "Hemijska, biohemijska i mikrobiološka karakterizacija Trifolium pratense L." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=87893&source=NDLTD&language=en.

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Hemijska karakterizacija ekstrakata  <em>T. pratense </em>L.  određena je LC-MS-MS, a etarskih ulja GC-MS analizom, pri čemu je  identifikovano vi&scaron;e bioaktivnih jedinjenja.  Spektrofotometrijskim metodama ispitan je antioksidantni potencijal ekstrakata i etarskih ulja. Hepatoprotektivni efekat određen je  na  homogenatu i hemolizatu jetre laboratorijskih mi&scaron;eva.  Budući da  ova biljka ima visok sadržaj izoflavona, određena je estrogena, antiestrogena aktivnost, kao i citotoksičnost ekstrakata. An

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23

Andraud-Dieu, Amandine. "Recherche de molécules antimicrobiennes d'origine lichénique : Etude phytochimique de trois lichens & approche synthétique de deux composés actifs." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0029/document.

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L’étude physicochimique de trois lichens récoltés en Limousin, Usnea florida, Flavoparmelia caperata et Cladonia incrassata, a permis d’isoler et de caractériser 16 composés issus du métabolisme secondaire. Dans un premier temps, ces lichens ont été sélectionnés lors d’un criblage analytique préliminaire réalisé sur 17 espèces. L’activité antimicrobienne des extraits acétoniques a été évaluée, puis leur fractionnement bioguidé a été mis en œuvre. Les deux isomères de l’acide usnique, 3 dibenzofuranes, 4 depsides, 3 depsidones, un acide aliphatique, un phtalide et un stérol ont été isolés. Une

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Bhedi, Chinmayee D. "Quorum Sensing Signals Produced by Heterotrophic Bacteria in Black Band Disease (BBD) of Corals and Their Potential Role in BBD Pathogenesis." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3367.

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Black band disease (BBD) of corals is a temperature dependent, highly virulent, polymicrobial disease affecting reef-building corals globally. The microbial consortium of BBD is primarily comprised of functional physiological groups that include photosynthetic cyanobacteria, sulfate reducers, sulfide oxidizers and a vast repertoire of heterotrophic bacteria. Quorum sensing (QS), the cell-density dependent communication phenomenon in bacteria, is known to induce expression of genes for a variety of virulence factors in diseases worldwide. Microbes capable of QS release signals such as acyl homo

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Araujo, Rafael Canonenco de. "Óleos essenciais de plantas brasileiras como manipuladores da fermentação ruminal in vitro." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-17032011-165221/.

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Na tentativa de reproduzir os benefícios ruminais dos ionóforos, pesquisadores exploram as propriedades antimicrobianas dos compostos secundários dos vegetais. Técnicas in vitro de produção de gás são amplamente utilizadas nas etapas iniciais de pesquisa. Óleos essenciais são compostos hidrofóbicos, sendo comum sua diluição com etanol em experimentos in vitro. Etanol é metabolizado no ambiente ruminal, havendo principalmente produção de acetato. No primeiro experimento, o objetivo foi avaliar o efeito de 10, 100 e 1000 µL de etanol em 75 mL de fluido ruminal tamponado, correspondendo a 0,13; 1

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Pereira, Sara Margarida Filipe. "Pesquisa de novos metabolitos secundários bioactivos em bactérias de sedimentos marinhos." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8486.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>O principal objectivo deste trabalho foi explorar o potencial biotecnológico sobre o ponto de vista microbiológico, de compostos químicos produzidos por bactérias marinhas presentes em sedimentos marinhos da plataforma continental portuguesa. Um total de 67 amostras de sedimentos marinhos recolhidos nos arquipélagos dos Açores, Madeira e da região de Sesimbra foram processados de forma a estudar o seu potencial biotecnológico a nível de actividade antimicrobiana e citotóxica. Destes sedimentos marinhos, isolara

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Sathekge, Ntshakga Rinah. "Comparison of secondary metabolite content and antimicrobial activity of four Hypoxis species used in traditional medicine." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/25775.

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Hypoxis (commonly known as African potato, Ilabatheka, Inkomfe, sterretjie or yellow starflowers and also as monna wa maledu or thitidi) is a genus of the family Hypoxidaceae. The rootstocks of Hypoxis species, particularly H. hemerocallidea, are well-known to be used in traditional medicine for the treatment of different ailments, such as urinary tract infection, epilepsy, prostate cancer and onset diabetes. Several visits have been made to the Faraday Medicinal Market and Abey Bailey Nature Reserve in Johannesburg to determine the availability of Hypoxis plant materials. From these visits, i

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Oliveira, Bruno Francesco Rodrigues de. "Análise das atividades antimicrobiana e citotóxica de actinobactérias isoladas de diversos habitats." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4835.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-29T14:44:05Z No. of bitstreams: 2 Dissertação - Bruno Francesco Rodrigues de Oliveira - 2015.pdf: 3313694 bytes, checksum: 5cb9779c379ed9f47de7c0d65abeb95b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-29T14:47:16Z (GMT) No. of bitstreams: 2 Dissertação - Bruno Francesco Rodrigues de Oliveira - 2015.pdf: 3313694 bytes, checksum: 5cb9779c379ed9f47de7c0d65abeb95b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac

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Silva, Eliane de Oliveira. "Otimização das condições de cultivo e investigação das atividades citotóxica e antimicrobiana de metabólitos secundários do fungo endofítico Drechslera ravenelii." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-08062010-161118/.

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O interesse na obtenção de novos fármacos a partir de micro-organismos endofíticos vem crescendo, uma vez que esta é uma fonte ainda pouco explorada. Além disso, o estudo das interações entre plantas e micro-organismos tem sido amplamente discutido ao longo dos últimos anos. No presente trabalho, o fungo endofítico Drechslera ravenelii (SS33), isolado das folhas de Smallanthus sonchifolius (yacon), foi cultivado sob diferentes condições fermentativas, objetivando a determinação das melhores condições para produzir metabólitos secundários com atividades antimicrobiana e/ou citotóxica. Para tal

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Corrêa, Cristina Bani. "Potencial antimicrobiano de resíduos agroindustriais sobre Listeria monocytogenes." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11141/tde-22112011-091434/.

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Os compostos fenólicos e os glucosinolatos vêm sendo pesquisados quanto à atividade antimicrobiana contra diversos microrganismos patogênicos, dentre eles a Listeria monocytogenes, um perigoso contaminante de alimentos. Este trabalho teve como objetivo principal avaliar resíduos agroindustriais com atividade contra Listeria monocytogenes, bem como identificar a composição química, visando a aplicação na indústria de alimentos. Neste trabalho foram analisados 23 resíduos agroindustriais. Os extratos destes resíduos foram preparados a partir de cinco solventes (hexano; clorofórmio; acetato de et

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Pino, Robles Joyce Dione del. "Acción antimicrobiana de los metabolitos secundarios de hojas y flores de Nicotiana paniculata (tabaco cimarrón), extraídos de las Lomas de Lachay." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2008. https://hdl.handle.net/20.500.12672/230.

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El presente trabajo reporta la actividad antimicrobiana y antifúngica de extractos obtenidos de hojas y flores de Nicotiana paniculata L, especie endémica del Perú cuyas muestras fueron colectadas en las Lomas de Lachay, en el Departamento de Lima. Se estudió la actividad antimicrobiana comparando los métodos de Kirby Bauer o disco difusión y el método de excavación placa cultivo encontrando que el método de excavación es más sensible para evaluar actividad antimicrobiana. Las cepas utilizadas fueron Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 653

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Pino, Robles Joyce Dione del, and Robles Joyce Dione del Pino. "Acción antimicrobiana de los metabolitos secundarios de hojas y flores de Nicotiana paniculata (tabaco cimarrón), extraídos de las Lomas de Lachay." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2008. http://cybertesis.unmsm.edu.pe/handle/cybertesis/230.

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El presente trabajo reporta la actividad antimicrobiana y antifúngica de extractos obtenidos de hojas y flores de Nicotiana paniculata L, especie endémica del Perú cuyas muestras fueron colectadas en las Lomas de Lachay, en el Departamento de Lima. Se estudió la actividad antimicrobiana comparando los métodos de Kirby Bauer o disco difusión y el método de excavación placa cultivo encontrando que el método de excavación es más sensible para evaluar actividad antimicrobiana. Las cepas utilizadas fueron Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 653

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Vargas, Aline Garcias de. "Influência da sazonalidade na composição química e nas atividades antioxidante e antimicrobiana das folhas de ora-pro-nobis (Pereskia aculeata Miller)." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2281.

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CAPES<br>Em meio a grande biodiversidade da flora brasileira, a ora-pro-nobis (Pereskia aculeata Miller) começou a ganhar visibilidade principalmente devido ao alto teor de proteínas presente em suas folhas, passando a ser utilizada então na alimentação. Visto que a colheita pode se dar durante todo o ano, não são raras as possíveis variações sazonais em sua composição e atividade. Com o objetivo de melhor conhecer as propriedades biológicas e os constituintes químicos desta espécie, considerando duas estações de coleta do material vegetal (inverno e verão), foi realizada a análise da composiç

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Barthélémy, Morgane. "Etude de la diversité chimique et biologique d’endophytes de palmiers." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS563.

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Dans cette étude, le palmier Astrocaryum sciophilum a été choisi comme modèle pour l'étude de ses endophytes foliaires. Du fait de sa longévité, nous avons cherché à mettre en évidence une communauté compétitive d’endophytes en fonction de l’âge de ses feuilles. Afin d’évaluer si les métabolites produits par ces endophytes pourraient être utilisés en santé humaine, les extraits de chaque endophyte ont été testés contre Staphylococcus aureus résistant à la méticilline (SARM) ainsi que pour leur activité quorum quenching (QQ). En parallèle, afin d’identifier un rôle écologique de protection de l

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Sanchez, Perez Jorge Andres. "Actividad antimicrobiana de metabolitos secundarios de Aspergillus fumigatus sobre cepas clínicas de Staphylococcus aureus y Streptococcus pneumoniae - Instituto de Medicina Tropical “Daniel Alcides Carrión” UNMSM." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/10285.

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Evalúa la actividad antimicrobiana de metabolitos secundarios de Aspergillus fumigatus sobre cepas clínicas de Staphylococcus aureus y Streptococcus pneumoniae. La fermentación líquida de un aislamiento clínico de Aspergillus fumigatus fue realizada en un caldo líquido Sulfato, Papa y Dextrosa (SPG). La extracción de metabolitos del caldo de cultivo fermentado fue realizada usando acetato de etilo. Se evaluó la actividad antimicrobiana sobre cepas clínicas de cocos Gram positivos mediante los métodos de disco y pozo difusión. Se obtuvo una media de 24 y 23 mm sobre Staphylococcus aureus sensib

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Navarri, Marion. "Métabolites secondaires de champignons de sédiments marins profonds : criblages génétique et fonctionnel et caractérisation structurale de molécules antimicrobiennes." Thesis, Brest, 2016. http://www.theses.fr/2016BRES0127/document.

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La propagation des micro-organismes résistants aux antibiotiques menace le système mondial de santé publique. Pour lutter contre ce phénomène, le renouvellement des molécules utilisées en antibiothérapie est devenu une priorité mondiale. Les antibiotiques étant principalement d’origine microbienne, l’étude des micro-organismes et de leurs métabolites s’est donc renforcée et s’oriente vers des écosystèmes peu explorés comme les biotopes marins.Nous avons exploré les activités antimicrobiennes d’une collection de 183 champignons isoles de sédiments marins profonds et collectés entre 4 et 1884 mè

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Meirelles, Casella Thiago. "Composés antimicrobiens ou cytotoxiques à partir de micro-organismes endophytes foliaires." Thesis, Antilles-Guyane, 2014. http://www.theses.fr/2014AGUY0836/document.

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En raison de la nature symbiotique des micro-organismes endophytes, cette étude visait à étudier l'activité antibactérienne, antifongique et cytotoxique chez les métabolites secondaires des extraits endophytes foliaires de plantes de l'Amazonie brésilienne et du Cerrado. Dans ce travail de thèse 147 micro-organismes cultivables ont été isolés (130 champignons, 3 bactéries e 14 champignons non-identifiés ou inconnus) à partir de 28 plantes (4 espèces collectées au Brésil et 24 en Guyane Française). Tous les micro-organismes furent identifiés par analyse moléculaire des régions spécifiques de l'

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Kristina, Tešanović. "Биолошка активност и хемијски састав аутохтоних врста гљива Coprinus comatus (O.F. Müll.) Pers. Gray, 1797 и Coprinellus truncorum (Scop.) Redhead, Vilgalys & Monclavo, 2001". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104928&source=NDLTD&language=en.

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У оквиру ове докторске дисертације испитана је биолошка активност екстраката плодних тела и потопљених култура (мицелије и филтрата) аутохтоних врста гљива <em>Coprinus comatus</em> и<em> Coprinellus truncorum</em>. Такође, испитан је  метаболизам фосфата мицелија обе врсте употребом нуклеарно магнетне резонантне спректроскопије (<sup>31</sup>Р NMR), утицај ванадијума на метаболизам фосфата као и идентификација облика ванадата присутних у ћелији мицелије (<sup>51</sup>V NMR). Утврђена је антирадикалска и антиоксидативна активност  етанолних,метанолних и водених екстраката гљива при ч

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Milena, Rašeta. "Детекција биоактивних супстанци одабраних врста гљива рода Ganoderma (Basidiomycota) и њихова биолошка активност". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=101530&source=NDLTD&language=en.

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 У оквиру ове докторске дисертације испитан је хемијски састав и биолошке активности ЕtOH, H<sub>2</sub>Oи CHCl<sub>3 </sub> екстраката четири врсте гљива рода<em> Ganoderma</em>  (Basidiomycota): <em> G. applanatum,  G. lucidum,G. pfeifferi,  G. resinaceum</em>  са територије Војводине.Хемијски састав анализираних врста је одређенприменом: ААЅ методе (састав макро-  имикроелемената у сувим остацима гљива) и LC-MS/MS технике (квантитативни састав фенолних једињења и флавоноида) при чему је детектовано 12 једињења. Спектрофотометријским методама је одређе

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ZENG, YING-YU, and 曾穎玉. "Investigation on the antimicrobial substances in metabolites of monascus species." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/51118574224807881665.

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Tabares, Paula. "Antimicrobial, anti-protease and immunomodulatory activities of secondary metabolites from Caribbean sponges and their associated bacteria." Doctoral thesis, 2011. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-67000.

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Marine sponges and their associated bacteria have been proven to be a rich source of novel secondary metabolites with therapeutic usefulness in infection and autoimmunity. This Ph.D. project aimed to isolate bioactive secondary metabolites from the marine sponges Amphimedon compressa, Aiolochroia crassa and Theonella swinhoei as well as from bacteria associated with different Caribbean sponges, specifically actinomycetes and sphingomonads. In this study, amphitoxin was isolated from the crude methanol extract of the sponge A. compressa and it was found to have antibacterial and anti-parasitic

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Griffin, Shane G. "Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure." Thesis, 2000. http://handle.uws.edu.au:8081/1959.7/243.

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Although the antomicrobial nature of essential oils and their major constituents, the terpenoids, has been widely investigated the mechanism of their antimicrobial action has not been subject to the same scrutiny. In this study the membrane disruptive nature of the terpenoids has been determined by experiments on the effects of terpenes on both microbial membrane and model lipid bilayer systems. These terpenes exhibited a range of membrane damaging effects. Experiments showed that the terpenoids were able to increase disorder in DPPC bilayers, and that antimicrobially active terpenoids cause i

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Lee, Ming-Shian, and 李明憲. "The exploration of fungal bioactive secondary metabolites from Phoma sp. NTOU4195 and the strategic development of antimicrobial natural products." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7e67b4.

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Heleno, Sandrina Alves. "Important human metabolites of phenolic acids from diet with wild mushrooms: chemical synthesis and studies of their antioxidant, antitumor and antimicrobial properties." Doctoral thesis, 2014. http://hdl.handle.net/1822/35721.

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Tese de doutoramento em Ciências (ramo de conhecimento em Química)<br>In this study, seven wild mushroom species (Ganoderma lucidum, Coprinopsis atramentaria, Rhodotus palmatus, Lactarius bertillonii, Lactarius vellereus, Xerocomus chrysenteron and Morchella esculenta), were characterized for their nutritional value (macronutrients and energy) and chemical composition (fatty acids, tocopherols, sugars and organic acids). A special focus was given to the analysis of phenolic acids and related compounds in mushroom fruiting bodies, spores and in vitro produced mycelia, by using chromatographic a

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Castro, Inês Manuel de Sousa Martins de. "Halocins and lanthipeptides from Haloferax mediterranei." Master's thesis, 2019. http://hdl.handle.net/10773/29244.

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The study of archaea's secondary metabolites, including archaeocins, is still limited. These antimicrobial peptides are poorly studied, especially when compared to the numerous studies on antibiotic production by other microorganisms. Only two types of archaeocins are known: i) halocins, produced by halophilic archaea and ii) sulfolobicins, produced by the extremely thermophilic Sulfolobus spp. There are also promising reports of archaeocins endowed with anticancer properties. Halophilic archaea have recently been found to be present in the human gut, thus showing that they are not confined to

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Melo, Fredilson da Veiga. "Isolation and identification of bioactive secondary metabolites from Salinispora arenicola obtained from ocean sediments from the Madeira Archipelago." Master's thesis, 2016. http://hdl.handle.net/10362/25621.

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Recently there has been an increase in pathogenic microorganisms resistant to antibiotics, infectious diseases and the appearance of new threats to human health and the economy. The inability of terrestrial natural product-based drugs to solve these problems has led scientists to look at unexplored habitats in search of new drugs. The marine environment has established itself as a remarkably rich treasure of new bioactive compounds with a wide range of biological properties, including antimicrobial, anti-fungal, anti-cancer, anti-inflammatory and cytotoxic. In the short time the marine enviro

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Su, Chin-Ling, and 蘇琴玲. "Evaluation of the Antimicrobial Effects by Herbal Medicine-San-Huang-Sie-Sin-Tang and its Metabolites with Oxacillin to Methicillin-resistant Staphylococcus aureus." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/27417530519222858220.

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碩士<br>中原大學<br>醫學工程研究所<br>96<br>In the field of medical science, bacteria infection is a serious problem for decades. Methicillin-resistant Staphylococcus aureus, MRSA, is the worldwide most noted multiple resistant bacteria strain which is resistant to Methicillin. Chinese herbal medicines are the treasures of our ancestors; some of them have the ability of killing bacteria, for example, Rhubarb, Coptis and Scute etc. Recently, the combination therapy of herbal medicine and Western medicine has been taken extensively. Also, there are more and more experts value the outcome of the combination.

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Nair, V. Anusree. "Bioprospecting of novel antimicrobial metabolites from Bacillus subtilis MBTDCMFRI Ba37 and Pseudomonas aeruginosa MBTDCMFRI Ps04 of tropical estuarine habitats of Cochin, India and its application in fish health management." Thesis, 2016. http://eprints.cmfri.org.in/14058/1/Thesis_2016_Anusree%20Nair.pdf.

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Aquaculture is an important economic activity the world over and about 90% of the global production is contributed by Asian countries. Global aquaculture has a persistent goal to maximize the production with optimal profit. Even though the aquaculture is growing at a rapid rate, the practice of aquaculture faces many challenges in its developing path. Intense cultivation in high densities significantly affect the environment by issues of used - up farm water discharges and heavy waste accumulation through hyper nutrification due to excessive feeding and high dietary nutrient composition

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Wierzbínska, A. "Evaluation of bioactive potential of a secondary metabolite produced by Penicillium nordicum." Master's thesis, 2017. http://hdl.handle.net/10198/14396.

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Fungi of the genus Penicillium are promising sources of bioactive substances. Fungal strains isolated from poorly characterized habitats are currently under active investigation as potential producers of biologically active compounds. Penicillium nordicum is mostly known by its ability to produce the mycotoxin ochratoxin A in several protein- and salt-rich food matrices like processed meat and cheese, but it can also produce an array of other secondary metabolites. In a previous study, strains of this species were found to produce, under specific growth conditions, one unidentified comp

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Sancha, Shirley Arnie dos Reis. "Avaliação da atividade antimicrobiana de metabolitos secundárias isolados a partir de uma planta usada na medicina tradicional africana." Master's thesis, 2015. http://hdl.handle.net/10451/24984.

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Tese de Mestrado, Química Farmacêutica e Terapêutica, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Esta dissertação teve como principal objetivo a identificação de compostos com atividade antibacteriana e antifúngica, isolados a partir da planta medicinal Africana Cleistochlamys kirkii permitindo assim a validação científica da sua aplicação no tratamento de doenças infeciosas, na medicina tradicional Moçambicana. Para tal, recolheu-se a parte da planta usada pelas populações – casca da raiz – e procedeu-se ao estudo fitoquímico bioguiado do extrato metanólico. Da fração do extrato

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