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Journal articles on the topic 'Antimicrobial metabolites'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Sanan, Antonius Oenunu, Triana Hertiani, and Yosi Bayu Murti. "TRACING OF SECONDARY METABOLITES AND ANTIMICROBIAL ACTIVITY OF SAPINDACEAE AS AN EFFORT TO PRESERVE HERBAL PLANTS: A REVIEW." Journal of Pharmaceutical Science and Application 6, no. 1 (2024): 1. http://dx.doi.org/10.24843/jpsa.2024.v06.i01.p01.

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Background: Sapindaceae plants in the community are used to treat various diseases. This plant is traced to contain secondary metabolites with various pharmacological activities, including antimicrobials. Objective: This review article aims to provide information about Sapindaceae plants with antimicrobial potential and summarize the content of secondary metabolite compounds. Methods: This review article uses sources from international and national journals obtained by online search and considers two criteria, namely inclusion and exclusion. Then, it was further selected to obtain data in the

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Ifediora, R. G., C. O. Anyamene, M. O. Ikele, and C. U. Ezebialu. "GC-MS Based Metabolomic Profiling of Streptomyces clavuligerus Isolated from Ocimum gratissimum Rhizosphere." Journal of Advances in Microbiology 23, no. 8 (2023): 28–35. http://dx.doi.org/10.9734/jamb/2023/v23i8741.

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Streptomyces clavuligerus is a member of the Actinobacteria family primarily known for its production of clavulanic acid antibiotic. The need for identification of new antimicrobials led to the identification of volatile components of S. clavuligerus metabolites using GC-MS. The isolate was obtained from Ocimum gratissimum rhizosphere using starch casein agar, and identified using molecular typing. The preliminary antibacterial screening of the isolate was carried out using some indicator bacteria from wound sites and urinary tract infection. Its bioactive metabolites were obtained using sub-m

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Yasmin, Rafida, Wulan Usfi Mafiroh, Anggiresti Kinasih, Aulia Noor Ramadhani, Rachmi Putri, and Endang Semiarti. "Potential of Orchids Secondary Metabolites as Anti-Cancer and Antimicrobial Based on Prediction of Phytochemical Activity with Online PASS-Software." Journal of Agromedicine and Medical Sciences 8, no. 1 (2022): 25. http://dx.doi.org/10.19184/ams.v8i1.26848.

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Abstract Orchidology is part of the branch of botany, it deals with a large family of monocotyledonous plants, Orchidaceae. Orchids have been used as traditional herbal medicines in Indonesia which are believed to be antimicrobial and anti-cancer. Orchids are able to produce secondary metabolites as their protective agent due to the extreme environment. Orchids have great diversity and potential to be the object of research, not only in experimental studies but also in a computational studies like in silico. Nowadays, molecular or metabolite data are available on the official-standard we

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Eltokhy, Mohamed A., Bishoy T. Saad, Wafaa N. Eltayeb, Mona R. El-Ansary, Khaled M. Aboshanab, and Mohamed S. E. Ashour. "A Metagenomic Nanopore Sequence Analysis Combined with Conventional Screening and Spectroscopic Methods for Deciphering the Antimicrobial Metabolites Produced by Alcaligenes faecalis Soil Isolate MZ921504." Antibiotics 10, no. 11 (2021): 1382. http://dx.doi.org/10.3390/antibiotics10111382.

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The continuous development of multidrug resistance pathogens with limited therapeutic options has become a great problem globally that impose sever health hazards. Accordingly, searching for of new antimicrobials became an urgent demand and great challenge. Soil significantly have been associated with several species that are antibiotic producers. In this study, combination of conventional screening methods with Liquid chromatography- Mass spectroscopy (LC/MS) and metagenomic nanopore sequence analysis have been conducted for the deciphering the active metabolites produced by soil isolate(s).

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R, Saravanakumar, Sudhakara Rao P, Sailaja B, and Manthira Moorthy S. "Fungal Biotransformation of Curcumin and Its Antibacterial Efficacy against Silkworm Flacherie Pathogens." Journal of Advances in Biology & Biotechnology 28, no. 2 (2025): 37–44. https://doi.org/10.9734/jabb/2025/v28i21966.

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Microbial transformation involves the production of new active biomolecules from natural products using microorganisms. This study focuses on exploring the microbial conversion of curcumin to develop improved antimicrobial agent for managing Flacherie disease in silkworms. The fungal cultures, Schizophyllum and Debaromyces species capable of converting curcumin into four metabolites. The chemical structures of the metabolites were analyzed using Nuclear Magnetic Resonance (NMR) spectroscopy, identifying them as tetrahydrocurcumin, hexahydrocurcumin, vanillin, and an unidentified metabolite. An

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Tolulope Mamora, Oluwatobi, Ayandiran Daniel Aina, S. G. Jonathan, S. Amodu, and K. O. Fagbemi. "Antimicrobial Activity of Silver Nanoparticles Biosynthesized by Metabolites of Lactic Acid Bacteria Isolated from Fermented Cyperus esculentus Milk." International Journal of Current Microbiology and Applied Sciences 13, no. 9 (2024): 236–52. https://doi.org/10.20546/ijcmas.2024.1309.026.

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Antimicrobial resistance is a growing global public health threat, with the rapid rise of multidrug-resistant microbes becoming alarming. The quest for natural antimicrobials has increased as consumers seek safer alternatives for ensuring food safety, nutrition, and sensory quality. This current study investigates the antimicrobial activities of biosynthesized silver nanoparticles (AgNPs) from metabolites of lactic acid bacteria (LAB) isolated from Cyperus esculentus milk. LAB were isolated and characterized using conventional and molecular methods. Metabolites from the LAB strains were used t

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Raupovna, Khadjimetova Sevara. "Study of antimicrobial metabolites of lactic acid bacteria." International Journal of Medical Sciences And Clinical Research 5, no. 6 (2025): 31–33. https://doi.org/10.37547/ijmscr/volume05issue06-06.

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In the past decades, detailed studies of SAB have revealed their ability to produce antimicrobial substances of various natures.Many SAB strains, in addition to lactic acid, produce a large number of non-specific low molecular weight compounds, such as organic acids, hydrogen peroxide, diacetyl, reuterin, etc., which determine the spectrum of their antimicrobial action.Many SAB strains, in addition to lactic acid, produce a large number of non-specific low molecular weight compounds, such as organic acids, hydrogen peroxide, diacetyl, reuterin, etc., which determine the spectrum of their antim

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Moats, William A., and Sandra A. Buckley. "Determination of Free Metabolites of Ceftiofur in Animal Tissues with an Automated Liquid Chromatographic Cleanup." Journal of AOAC INTERNATIONAL 81, no. 4 (1998): 709–13. http://dx.doi.org/10.1093/jaoac/81.4.709.

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Abstract Ceftiofur, a recently introduced antibiotic of the β-lactam group, is rapidly converted to both free and protein-bound metabolites when administered by the prescribed procedure, intramuscular injection. Free metabolites retain antimicrobial activity and may be detected by antibiotic-screening tests based on antimicrobial activity. It is thus desirable to distinguish ceftiofur metabolites from other antibiotics. A multiresidue procedure for β-lactams in milk was adapted for determination of free ceftiofur metabolites by collecting appropriate liquid chromatographic fractions during cle

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Durães, Fernando, Nikoletta Szemerédi, Decha Kumla, et al. "Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants." Marine Drugs 19, no. 9 (2021): 475. http://dx.doi.org/10.3390/md19090475.

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Marine-derived fungi constitute an interesting source of bioactive compounds, several of which exhibit antibacterial activity. These acquire special importance, considering that antimicrobial resistance is becoming more widespread. The overexpression of efflux pumps, capable of expelling antimicrobials out of bacterial cells, is one of the most worrisome mechanisms. There has been an ongoing effort to find not only new antimicrobials, but also compounds that can block resistance mechanisms which can be used in combination with approved antimicrobial drugs. In this work, a library of nineteen m

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Molina, Diana, Evelyn Angamarca, George Cătălin Marinescu, Roua Gabriela Popescu, and Gabriela N. Tenea. "Integrating Metabolomics and Genomics to Uncover Antimicrobial Compounds in Lactiplantibacillus plantarum UTNGt2, a Cacao-Originating Probiotic from Ecuador." Antibiotics 14, no. 2 (2025): 123. https://doi.org/10.3390/antibiotics14020123.

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Background/Objectives: Lactic acid bacteria (LAB) produce several diverse metabolites during fermentation that play key roles in enhancing health and food quality. These metabolites include peptides, organic acids, exopolysaccharides, and antimicrobial compounds, which contribute to gut health, immune system modulation, and pathogen inhibition. This study analyzed the intracellular (Met-Int) and extracellular metabolites (Met-Ext-CFS; cell-free supernatant) of Lactiplantibacillus plantarum UTNGt2, a probiotic strain isolated from Theobroma grandiflorum. Methods: The assessment was performed us

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Arora, Poonam, Madhukar Garg, Tanvi Gera, et al. "Antimicrobial Activity of Secondary Metabolites in Medicinal Plants: An Update." BIO Web of Conferences 86 (2024): 01040. http://dx.doi.org/10.1051/bioconf/20248601040.

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Plants have filled in as a significant wellspring of elements for conventional drugs for centuries. Verifiable records and present day ethno botanical field examines feature their significance in the conventional treatment of irresistible malady. Be that as it may, plants form just a minor level of present collection of FDA-endorsed antimicrobial medications. The present article gives an outline of active components of plants as hint for other wellspring of antimicrobial agents to be used in the battle against microscopic organisms. It additionally surveys the ethno botanical way to deal with

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Vijay, Kothari, Shah Aesha, Gupta Shivani, Punjabi Amruta, and Ranka Abhishikha. "Revealing the Antimicrobial Potential of Plants." International Journal of BioSciences and Technology (IJBST) ISSN: 0974-3987 3, no. 1 (2010): 1–20. https://doi.org/10.5281/zenodo.1438284.

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<strong>ABSTRACT</strong> Plants being capable of synthesizing a vast array of secondary metabolites with antimicrobial potential are a prospective source of new therapeutic agents. Methods for preparing crude plant extracts, and those for assessing their antimicrobial activity become important in this context, especially when the problem of drug resistance among pathogenic microbes has become prevalent. This review explores the different classes of secondary metabolites, various extraction procedures followed by different assays that can be used to determine their antimicrobial potential. The

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CO, Akalezi. "Phytochemistry and Antimicrobial Properties of Gmelina arborea (Verberaceae) Ethanolic Leaf Extract and its Secondary Metabolites." Journal of Natural & Ayurvedic Medicine 4, no. 4 (2020): 1–7. http://dx.doi.org/10.23880/jonam-16000283.

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The aim of this study was to determine the antimicrobial potential of Gmelina arborea ethanolic leaf extract which is used in traditional medicine for treating different ailments such as hallucinations, piles, abdominal pains, burning sensation, diabetes and fever. It is also intended to study its acidic, basic and neutral metabolites with a view to identify the phytochemical compounds responsible for the observed antimicrobial properties. Phytochemical screening was carried out on the airdried ethanolic leaf extract and its secondary metabolites in the Research Laboratory of Phytochemistry/ C

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Segundo, Walter Oliva Pinto Filho, Roberta Silva de Oliveira, Rildo Mendes Lima, et al. "Antimicrobial Potential of Metabolites in Fungal Strains Isolated from a Polluted Stream: Annulohypoxylon stygium WL1B5 Produces Metabolites against Extended-Spectrum Beta-Lactamase-Positive Escherichia coli." Antibiotics 12, no. 1 (2022): 27. http://dx.doi.org/10.3390/antibiotics12010027.

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The emergence of multidrug resistance in bacterial pathogens is a growing public health concern requiring solutions including the discovery of new antimicrobial drugs. Fungi have been used for decades as a source of antimicrobials. Ongoing screenings for newly characterized fungal strains producing antimicrobials include environments that are difficult to access like the deep sea, glaciers, wastewaters and environments polluted due to human activity. In the present study, fungal microorganisms were isolated from water samples taken from a polluted stream in the city of Manaus, AM, Brazil, and

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Rakhmawatie, Maya Dian, Mustofa Mustofa, Puspita Lisdiyanti, et al. "Antimicrobial compounds from intracellular and extracellular secondary metabolites of Actinobacteria InaCC A759." Indonesian Journal of Biotechnology 29, no. 4 (2024): 221. https://doi.org/10.22146/ijbiotech.82376.

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The World Health Organization (WHO) has determined a list of pathogens that require the development of new antimicrobials due to resistance problems; these include Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. In addition, Mycobacterium smegmatis has been used for antimycobacterial discovery to address the increasing burden of tuberculosis. In this study, optimization of antimicrobial activity, secondary metabolite profiling, and strain identification was conducted on Actinobacteria InaCC A759. Intracellular and extracellular extracts of Actinobacteria InaCC A759 were fo

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Hussain, Amjad, and Christopher J. Godwin. "Streptomyces sp. VITGV156 (MCC 4965), a quinoline producing Streptomyces." Research Journal of Biotechnology 18, no. 10 (2023): 197–204. http://dx.doi.org/10.25303/1810rjbt1970204.

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The genus Streptomyces is renowned for its ability to synthesize a wide range of secondary metabolites, encompassing antimicrobial, anticancer, antiviral, antioxidant, immunosuppressant and antimalarial properties. In this study, we focused on Streptomyces sp. VITGV156 to explore its potential in producing quinoline, a secondary metabolite, leveraging the species' extensive biosynthetic gene repertoire. The complete genome of Streptomyces sp. VITGV156 was sequenced using Illumina technology and NextSeq. Genome analysis unveiled 29 Biosynthetic Gene Clusters (BGCs), including 7 PKS (Polyketide

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Hoai Trinh, Phan Thi, Ngo Thi Duy Ngoc, Vo Thi Dieu Trang, et al. "EFFECT OF CULTURE CONDITIONS FOR ANTIMICROBIAL ACTIVITY OF MARINE - DERIVED FUNGUS ASPERGILLUS FLOCCULOSUS 01NT.1.1.5." Vietnam Journal of Biotechnology 15, no. 4 (2018): 721–28. http://dx.doi.org/10.15625/1811-4989/15/4/13415.

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The biosynthesis of compounds with antibiotic activity produced by marine fungi, strongly depends on their growth conditions. A good understanding of the role of culture conditions in the biosynthesis of metabolites may lead to better exploitation of microbial metabolites. In this study, the influence of culture conditions including incubation period, initial pH and salinity on antimicrobial activity and secondary metabolites production of marine fungus 01NT.1.1.5 was investigated. This isolate, obtained from sponge Stylissa sp. in Nha Trang Bay, exhibited a broad spectrum of in vitro antimicr

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Habbu, Prasanna, Vijayanand Warad, Rajesh Shastri, Smita Madagundi, and Venkatrao H. Kulkarni. "Antimicrobial metabolites from marine microorganisms." Chinese Journal of Natural Medicines 14, no. 2 (2016): 101–16. http://dx.doi.org/10.1016/s1875-5364(16)60003-1.

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ABATE, DAWIT, and WOLF-RAINER ABRAHAM. "Antimicrobial metabolites from Lentinus crinitus." Journal of Antibiotics 47, no. 11 (1994): 1348–50. http://dx.doi.org/10.7164/antibiotics.47.1348.

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Manojlovic, Nedeljko T., Milan Novakovic, Vladeta Stevovic, and Slavica Solujic. "Antimicrobial Metabolites from Three SerbianCaloplaca." Pharmaceutical Biology 43, no. 8 (2005): 718–22. http://dx.doi.org/10.1080/13880200500387257.

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Valeeva, Lia R., Ashley L. Dague, Mitchell H. Hall, et al. "Antimicrobial Activities of Secondary Metabolites from Model Mosses." Antibiotics 11, no. 8 (2022): 1004. http://dx.doi.org/10.3390/antibiotics11081004.

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Plants synthetize a large spectrum of secondary metabolites with substantial structural and functional diversity, making them a rich reservoir of new biologically active compounds. Among different plant lineages, the evolutionarily ancient branch of non-vascular plants (Bryophytes) is of particular interest as these organisms produce many unique biologically active compounds with highly promising antibacterial properties. Here, we characterized antibacterial activity of metabolites produced by different ecotypes (strains) of the model mosses Physcomitrium patens and Sphagnum fallax. Ethanol an

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Owolabi, Lawrence, Cajethan Ezeamagu, and Godswill Anyasor. "Antibacterial properties of secondary metabolites produced from wasp-associated bacteria in Isara, Remo-North, Ogun State, Nigeria." Journal of Microbiology and Infectious Diseases 14, no. 2 (2024): 80. http://dx.doi.org/10.5455/jmid.2024.v14.i2.6.

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Background: Antibiotic resistance is a global problem with high morbidity and mortality in healthcare institution that requires an antimicrobial alternative and ittle is known of antibacterial agents derived from insect sources. Aim: The aim of the study was to examined antibacterial properties of secondary metabolites from insect-associated bacteria. Methods: Thirty-three wasps were obtained from abandoned structures in a local Community. Bacteria were isolated and identified by Sanger sequencing method. The metabolites were extracted and antibacterial potential was tested against different p

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Pirog, T. P. "MICROBIAL CO-CULTIVATION: DISCOVERY OF NOVEL SECONDARY METABOLITES WITH DIFFERENT BIOLOGICAL ACTIVITIES." Biotechnologia Acta 16, no. 1 (2023): 21–39. http://dx.doi.org/10.15407/biotech16.01.021.

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In recent decades, overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making them a major problem for humanity. One of the most effective approaches to the discovery of new secondary antimicrobial metabolites is co-cultivation of microorganisms, in which the producer of the target products is grown together with competitive microorganisms ( inductors), in response to the presence of which silent biosynthetic genes of the producer strain are activated and an increase in the biological activity of the synthesized

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Mohammadi, Mehdi, Moj Khaleghi, Shahriyar Shakeri, Majid Askari Hesni, Mohammad Rasoul Samandari-Bahraseman, and Ava Dalvand. "Isolation of Actinobacteria Strains From Environmental Samples and Assessment of Their Bioactivity." Avicenna Journal of Clinical Microbiology and Infection 9, no. 1 (2022): 18–25. http://dx.doi.org/10.34172/ajcmi.2022.03.

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Background: Actinobacteria are widespread and live in a variety of habitats. Today, these bacteria are very important due to the production of various secondary metabolites with different biological activities. The present study aimed to isolate strains of Actinobacteria from different habitats (the Persian Gulf, Gandom Beryan area in the Lut Desert, and some plant roots). The anticancer and antimicrobial activities of secondary metabolites of these isolates were also investigated. Methods: Samples were taken from water of the Persian Gulf, soil of Gandom Beryan area in the Lut Desert, and pla

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Abdullahi, Bashir, and Amina M. Gumel. "Detection of antibiotic-producing microorganisms with antimicrobial activities against selected clinical isolates." Journal of Pharmacy & Bioresources 22, no. 2 (2025): 132–39. https://doi.org/10.4314/jpb.v22i2.5.

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Soil microorganisms, particularly from diverse environments, are known for producing bioactive compounds with potential applications in combating antibiotic-resistant pathogens. This study investigated the antimicrobial activities of secondary metabolites produced by microorganisms isolated from various soil samples sites within Ahmadu Bello University, Zaria-Nigeria. Potential antibiotic-producing microorganisms were isolated and screened for antibiotic production using crowded plate and dual-culture methods respectively. The isolated microorganisms were identified using phenotypic characteri

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Noval, Noval, Iwan Yuwindry, and Dahlia Syahrina. "Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method." Jurnal Surya Medika 5, no. 1 (2019): 143–54. http://dx.doi.org/10.33084/jsm.v5i1.954.

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Bundung plants (Actinuscirpus Grossus) are widely spread in Borneo and used by society empirically as antimicrobials. Nevertheless, the use of Bundung plants as traditional medicine has not been equipped with convincing data, because there is no research that is related to the plants. In order to the use of the plants accountable, it is necessary to conduct research about phytochemical screening studies and tests the antimicrobial activity of ethanol extract of Bundung plants to staphylococcus aureusandEschericia Coli bacteria. Moreover, extraction does with maceration method. Secondary metabo

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Eshboev, Farkhod, Nilufar Mamadalieva, Pavel Nazarov, et al. "Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms." Antibiotics 13, no. 3 (2024): 271. http://dx.doi.org/10.3390/antibiotics13030271.

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Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous new antimicrobial compo

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Mishra, Mamta, Upasana Sharma, Manisha Rawat, Harshvardhan Harshvardhan, Shelley Sardul Singh, and Suresh Korpole. "Antimicrobial Compounds from Anaerobic Microorganisms: A Review of an Untapped Reservoir." Applied Microbiology 5, no. 3 (2025): 68. https://doi.org/10.3390/applmicrobiol5030068.

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Anaerobes, the oldest evolutionary life forms, have been unexplored for their potential to produce secondary metabolites due to the difficulties observed in their cultivation. Antimicrobials derived from anaerobic bacteria are an emerging and valuable source of novel therapeutic agents. The urgent need for new antimicrobial agents due to rising antibiotic resistance has prompted an investigation into anaerobic bacteria. The conventional method of antimicrobial discovery is based on cultivation and extraction methods. Antibacterial and antifungal substances are produced by anaerobic bacteria, b

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Zolotykh, Denis Sergeyevich, Dmitriy Igorevich Pozdniakov, Margarita Petrovna Glushko, and Жанна Владимировна Daironas. "CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF SECONDARY METABOLITES FROM IMPATIENS BALSAMINA." chemistry of plant raw material, no. 3 (September 26, 2022): 27–47. http://dx.doi.org/10.14258/jcprm.20220310518.

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The review summarizes the literature data concerning the chemical composition of secondary metabolites and the types of biological activity of extracts and separate groups of secondary metabolites of Impatiens balsamina. First, data are given concerning the different types of biological activity of the extracts. Further, individual groups of secondary metabolites are considered, the corresponding structural formulas and types of biological activity established for this group of secondary metabolites are given. An attempt has been made to present the material about chemical composition and type

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Pahalagedara, Amila S. N. W., Steve Flint, Jon Palmer, et al. "Non-Targeted Metabolomic Profiling Identifies Metabolites with Potential Antimicrobial Activity from an Anaerobic Bacterium Closely Related to Terrisporobacter Species." Metabolites 13, no. 2 (2023): 252. http://dx.doi.org/10.3390/metabo13020252.

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This work focused on the metabolomic profiling of the conditioned medium (FS03CM) produced by an anaerobic bacterium closely related to Terrisporobacter spp. to identify potential antimicrobial metabolites. The metabolome of the conditioned medium was profiled by two-channel Chemical Isotope Labelling (CIL) LC-MS. The detected metabolites were identified or matched by conducting a library search using different confidence levels. Forty-eight significantly changed metabolites were identified with high confidence after the growth of isolate FS03 in cooked meat glucose starch (CMGS) medium. Some

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Jadimurthy, Ragi, Swamy Jagadish, Siddaiah Chandra Nayak, Sumana Kumar, Chakrabhavi Dhananjaya Mohan, and Kanchugarakoppal S. Rangappa. "Phytochemicals as Invaluable Sources of Potent Antimicrobial Agents to Combat Antibiotic Resistance." Life 13, no. 4 (2023): 948. http://dx.doi.org/10.3390/life13040948.

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Plants have been used for therapeutic purposes against various human ailments for several centuries. Plant-derived natural compounds have been implemented in clinics against microbial diseases. Unfortunately, the emergence of antimicrobial resistance has significantly reduced the efficacy of existing standard antimicrobials. The World Health Organization (WHO) has declared antimicrobial resistance as one of the top 10 global public health threats facing humanity. Therefore, it is the need of the hour to discover new antimicrobial agents against drug-resistant pathogens. In the present article,

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Beck, Frederik, Ninfa Rangel Pedersen, and Dennis Sandris Nielsen. "Fermented Rapeseed and Soybean Alone and in Combination with Macro Algae Inhibit Human and Pig Pathogenic Bacteria In Vitro." Microorganisms 12, no. 5 (2024): 891. http://dx.doi.org/10.3390/microorganisms12050891.

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Higher plants produce secondary metabolites expressing antimicrobial effects as a defense mechanism against opportunistic microorganisms living in close proximity with the plant. Fermentation leads to bioconversion of plant substrates to these bioactive compounds and their subsequent release via breakdown of plant cell walls. Fermented feed products have recently started to become implemented in the pig industry to reduce overall disease pressure and have been found to reduce events such as post-weaning diarrhea. In this study, we investigate the antimicrobial potential of fermented soybean- a

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Cuevas-Cianca, Sofía Isabel, Cristian Romero-Castillo, José Luis Gálvez-Romero, Eugenio Sánchez-Arreola, Zaida Nelly Juárez, and Luis Ricardo Hernández. "Latin American Plants against Microorganisms." Plants 12, no. 23 (2023): 3997. http://dx.doi.org/10.3390/plants12233997.

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The constant emergence of severe health threats, such as antibacterial resistance or highly transmissible viruses, necessitates the investigation of novel therapeutic approaches for discovering and developing new antimicrobials, which will be critical in combating resistance and ensuring available options. Due to the richness and structural variety of natural compounds, techniques centered on obtaining novel active principles from natural sources have yielded promising results. This review describes natural products and extracts from Latin America with antimicrobial activity against multidrug-

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K.A, Lawan, Adebayo I.A, Ungokore H.Y, and Akinola S.A. "A Systematic review of Aspergillus fumigatus metabolites of antimicrobial importance." KIU Journal of Health Sciences 5, no. 1 (2025): 15–33. https://doi.org/10.59568/kjhs-2025-5-1-02.

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Background: Aspergillus fumigatus is a common fungus in many environments; from the air we breathe and the ground beneath us to even the International Space Station. It has proven capable of yielding no fewer than 226 bioactive compounds, 36 of which are chemical structures that may be connected to the genome of Aspergillus fumigatus through biosynthetic gene clusters (BGCs). This systematic review aims to investigate the status of Aspergillus fumigatus metabolites that are of antimicrobial importance. Methods: PubMed was systematically searched on November 5, 2023, using the algorithm "Asperg

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Bahri, Saiful, Theodora Christy, Yulius Nanda Setiawan, et al. "Uji Antimikroba Ekstrak Kapang Endofit RLC 5 Akar Tanaman Kayu Jawa (Lannea coromandelica (Houtt.) Merr.)." Pharmaceutical Journal of Indonesia 9, no. 1 (2023): 65–70. http://dx.doi.org/10.21776/ub.pji.2023.009.01.10.

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Java root (Lannea coromandelica (Houtt.) Merr.) contains many saponins, steroids and alkoloids which are known to have potential as antimicrobials. This study aims to examine the antimicrobial activity of isolates of endophytic molds from the roots of Javanese wood plants with RLC code 5 against pathogenic fungi and bacteria. The research was carried out by rejuvenating RLC 5 isolates for 7 days and then carrying out macroscopic and microscopic characteristics. Fermentation was carried out for 21 days to reach the stationary phase in producing secondary metabolites, then extraction was carried

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Math, Halaswamy Hire, Sreenivasa Nayaka, Muthuraj Rudrappa, et al. "Isolation, Characterization of Pyraclostrobin Derived from Soil Actinomycete Streptomyces sp. HSN-01 and Its Antimicrobial and Anticancer Activity." Antibiotics 12, no. 7 (2023): 1211. http://dx.doi.org/10.3390/antibiotics12071211.

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The present study demonstrated the isolation, characterization, and antimicrobial and anticancer activity of active metabolite produced from mining-soil-derived actinomycetes. Among the 21 actinomycete isolates, the isolate HSN-01 exhibited significant antimicrobial activity in primary screening and was identified as Streptomyces sp. through 16S rRNA gene sequencing. The active metabolite was separated, purified, and confirmed through UV–Vis spectroscopy, FTIR, HR-ESI-MS, and NMR analysis and identified as pyraclostrobin. Further, the active metabolite pyraclostrobin was tested for antimicrobi

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K., Monika, Tanu Malik, Rakesh Gehlot, et al. "Antimicrobial Property of Probiotics." Environment Conservation Journal 22, SE (2021): 33–48. http://dx.doi.org/10.36953/ecj.2021.se.2204.

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There is an expanding request from customers for regular antimicrobial substances that can be utilised for food safeguarding and replace the synthetic food additive. The antimicrobial development of precisely critical lactic acid microorganisms as starter cultures and various probiotics microorganisms is the guideline subject of an audit. The probiotics produce metabolites, for example, natural acids (lactic and acetic acid), hydrogen peroxide, ethanol, diacetyl, acetaldehyde, acetone, carbon dioxide, reuterin, reutericyclin, and bacteriocins, etc. The capability of utilising metabolite bacter

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García, Wendy, Mariela Pérez-Cárdena, Katherine Trivino-Cepeda, Andrea C. Zurita-Leal, and Marco Esteban Gudiño Gomezjurado. "Antimicrobial activity of edaphic microorganisms against clinically relevant bacteria." Bionatura Journal 1, no. 3 (2024): 1–9. http://dx.doi.org/10.70099/bj/2024.01.03.5.

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In recent decades, the emergence of bacterial resistance to antimicrobial agents has raised a significant challenge in the medical field. The search for new therapeutic alternatives has become a challenging task. With an estimated diversity ranging from 100 million to 1 billion different bacterial types with unique functions and roles, it is critical to find antimicrobial solutions Recent studies have focused on bacterial species in soil as a source of antimicrobial compounds that can be used as potential therapeutics for the treatment of infectious diseases. This study focused on isolating, c

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Mirbakhsh, Maryam, Babak Ghaednia, and Akram Sadat Tabatabaee Bafroee. "An In Vivo and In Vitro Assessment of the Probiotic Potentials of Indigenous Halotolerant Bacteria on Growth Performance and Digestive Enzymes of White Leg Shrimp (Litopenaeus vannamei) in High-Salinity Waters." Aquaculture Nutrition 2022 (March 7, 2022): 1–12. http://dx.doi.org/10.1155/2022/2704224.

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The present study was aimed at evaluating Bacillus subtilis subsp. inaquosorum strain IS02 (B.s.i. IS02; GenBank accession number: JN856456.1) to determine the growth kinetics of antimicrobial metabolite production in different ranges of environmental factors, such as salinity (15-55‰), pH (5-9), and temperature (30-40°C); to evaluate the lifespan of antimicrobial metabolites in different ranges of salinity (0-57‰), pH (2-12), and temperature (35-121°C); and to investigate the effect of B.s.i. IS02 as an additive to functional feed on the digestive activity of Litopenaeus vannamei under high-s

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Abbood, Zinah Ameer, Saja Adel Abdul Sada, and Rana Hadi H. Al-Shammari. "Anti-Microbial Activity of Aspergillus terreus Bioactive Compounds Extract." IOP Conference Series: Earth and Environmental Science 1371, no. 2 (2024): 022006. http://dx.doi.org/10.1088/1755-1315/1371/2/022006.

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Abstract Microorganisms that possess antimicrobial properties opened up new possibilities in the fight against microbes, A very effective microorganism in combating pathogenic microbes is the Aspergillus terreus. All species of Aspergillus do not have appropriate and similar antimicrobial effects, and it is important to identify and isolate species with antimicrobial effects. In this research, moldy citrus fruits were sampled and Aspergillus was isolated and identified from them. 3 species of Aspergillus terreus, Aspergillus niger isolate 1 and Aspergillus niger isolate 2 were isolated. After

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Rozhkova, I. V., A. V. Begunova, and V. A. Leonova. "Antimicrobial activity metabolites of probiotic cultures." DAIRY INDUSTRY, no. 9 (2022): 30–31. http://dx.doi.org/10.31515/1019-8946-2022-09-30-31.

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Li, Jianxiong, Genhui Chen, John M. Webster, and Eva Czyzewska. "Antimicrobial Metabolites from a Bacterial Symbiont." Journal of Natural Products 58, no. 7 (1995): 1081–86. http://dx.doi.org/10.1021/np50121a016.

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Wallace, R. John. "Antimicrobial properties of plant secondary metabolites." Proceedings of the Nutrition Society 63, no. 4 (2004): 621–29. http://dx.doi.org/10.1079/pns2004393.

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Increasing awareness of hazards associated with the use of antibiotic and chemical feed additives has accelerated investigations into plants and their extracts as feed additives. The present review mainly discusses two classes of plant secondary compounds in this context, i.e. essential oils and saponins. The broader potential of plants and their extracts is illustrated by the progress of an EC Framework 5 project, ‘Rumen-up’. Dietary inclusion of a commercial blend of essential oils causes markedly decreased NH3production from amino acids in rumen fluid taken from sheep and cattle. This effec

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Tian, Hui, Jamil Shafi, Mingshan Ji, Yuhui Bi, and Zhiguo Yu. "Antimicrobial Metabolites from Streptomyces sp. SN0280." Journal of Natural Products 80, no. 4 (2017): 1015–19. http://dx.doi.org/10.1021/acs.jnatprod.6b01016.

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Baranova, A. A., Y. V. Zakalyukina, A. P. Tyurin, et al. "Antimicrobial Metabolites from Pig Nasal Microbiota." Russian Journal of Bioorganic Chemistry 50, no. 2 (2024): 354–74. http://dx.doi.org/10.1134/s1068162024020237.

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Overton, Jessie M., Lyndsey Linke, Roberta Magnuson, Corey D. Broeckling, and Sangeeta Rao. "Metabolomic Profiles of Multidrug-Resistant Salmonella Typhimurium from Humans, Bovine, and Porcine Hosts." Animals 12, no. 12 (2022): 1518. http://dx.doi.org/10.3390/ani12121518.

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Antimicrobial resistance (AMR) is a global public health threat, yet tools for detecting resistance patterns are limited and require advanced molecular methods. Metabolomic approaches produce metabolite profiles and help provide scientific evidence of differences in metabolite expressions between Salmonella Typhimurium from various hosts. This research aimed to evaluate the metabolomic profiles of S. Typhimurium associated with AMR and it compares profiles across various hosts. Three samples, each from bovine, porcine, and humans (total n = 9), were selectively chosen from an existing library

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Etta, Kanya Kumari, Chiranjeevi Chetapalli, Vijayalakshmi Muvva, and Nagaraju Kumbha. "Taxonomic Profile and Antimicrobial Potential of Brachybacterium conglomeratum VLCH–15 Isolated from Mangroves of Machilipatnam, Andhra Pradesh, India." Journal of Advances in Microbiology 25, no. 2 (2025): 22–33. https://doi.org/10.9734/jamb/2025/v25i2898.

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Actinobacteria of mangrove origin become a vital source of novel antibiotics with high therapeutic potential. Hence, the current study has been focused on antimicrobial potential of secondary metabolites produced by rare actinobacterium isolated from mangrove ecosystem of Machilipatnam, Andhra Pradesh, India. Sediment samples collected from mangrove habitats were shade dried at room temperature. The samples were employed for isolation of actinobacteria by serial dilution followed by spread plate method. Yeast extract malt extract dextrose (YMD) agar, starch casein agar (SCA), actinomycetes iso

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Teshome, Ejigayehu, Sirawdink Fikreyesus Forsido, H. P. Vasantha Rupasinghe, and Ebisa Olika Keyata. "Potentials of Natural Preservatives to Enhance Food Safety and Shelf Life: A Review." Scientific World Journal 2022 (September 23, 2022): 1–11. http://dx.doi.org/10.1155/2022/9901018.

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Food-borne illnesses are a significant concern for consumers, the food industry, and food safety authorities. Natural preservatives are very crucial for enhancing food safety and shelf life. Therefore, this review aimed to assess the literature regarding the potential of natural preservatives to enhance food safety and extend the shelf life of food products. The review paper indicated that natural antimicrobial agents that inhibit bacterial and fungal growth for better quality and shelf life have been of considerable interest in recent years. Natural antimicrobials are mainly extracted and iso

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Perigo, Crislene V., Lenita L. Haber, Roselaine Facanali, et al. "Essential Oils of Aromatic Plant Species from the Atlantic Rainforest Exhibit Extensive Chemical Diversity and Antimicrobial Activity." Antibiotics 11, no. 12 (2022): 1844. http://dx.doi.org/10.3390/antibiotics11121844.

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Microbial resistance, caused by the overuse or inadequate application of antibiotics, is a worldwide crisis, increasing the risk of treatment failure and healthcare costs. Plant essential oils (EOs) consist of hydrophobic metabolites with antimicrobial activity. The antimicrobial potential of the chemical diversity of plants from the Atlantic Rainforest remains scarcely characterized. In the current work, we determined the metabolite profile of the EOs from aromatic plants from nine locations and accessed their antimicrobial and biocidal activity by agar diffusion assays, minimum inhibitory co

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Dilshad, Rimsha, Nazia Jamil, and Rida Batool. "Biosynthetic Gene Clusters in Bacteria: A Review." Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences 58, no. 3 (2022): 29–42. http://dx.doi.org/10.53560/ppasb(58-3)665.

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Soil is a nutrient-rich environment that harbors billions of microbial species. The diversity of microbes in an environment varies with the change in edaphic factors. To survive these environmental changes, microbes produce secondary metabolites which are not directly associated with their growth and reproduction. Bacterial genomes possess biosynthetic gene clusters (BGC) which regulate the synthesis of these secondary metabolites. These BGCs encode for megasynthases such as nonribosomal peptide synthases (NRPS) and polyketide synthases (PKS) which produce metabolites such as antimicrobial com

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