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Dissertations / Theses on the topic 'Antimicrobial peptites'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Bürkle, Carl-Philipp Stavros. "Die Expression antimikrobieller Peptide (Psoriasin, HBD-2 und HBD-3) in menschlicher Haut und deren Modulation in vivo - eine Untersuchung im xenogenen Haut-Transplantationsmodell." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-73827.

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In der humanen Haut spielen antimikrobielle Peptide (AP) bei Entzündungsgeschehen bakteriellen und nicht-bakteriellen Ursprungs eine bedeutende Rolle. Neben einer konstitutiven Expression AP können Zytokine deren vermehrte oder abgeschwächte Expression bewirken. In dieser Arbeit wurden die AP humanes β-Defensin (HBD) -2, HBD-3 und Psoriasin (PSO) in Bezug auf deren Expression in gesunder Haut und deren Modulation durch Zytokine in vivo anhand des xenogenen NOD-SCID-Maus-Transplantationsmodells untersucht. Nach erfolgreicher Transplantation von humaner Haut auf NOD-SCID Mäuse wurden die Zytokin
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2

Rolland, Jean-Luc. "Aspects moléculaires et biochimiques des stylicines, peptides multifonctionnels identifiés chez la crevette bleue du Pacifique Litopenaeus stylirostris (Crustacea, Decapoda)." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20049.

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Les travaux présentés dans ce mémoire ont été motivés par l'importance économique de l'élevage de la crevette bleue du pacifique Litopenaeus stylirostris dont les fortes mortalités sont principalement dues au développement de maladies bactériennes et virales. Ils ont consisté en la caractérisation des deux premiers membres d'une famille originale de peptides multifonctionnels présents chez les crevettes pénéides, les stylicines. Ces peptides, nommés stylicines 1 et 2, sont des peptides anioniques (pI < 6.0), formés d'une région amino-terminale riche en résidus de type proline et d'une régio
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3

Zerfas, Breanna L. "Creating Novel Antimicrobial Peptides: From Gramicidin A to Screening a Cyclic Peptide Library." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107444.

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Thesis advisor: Jianmin Gao<br>As the threat of microbial resistance to antibiotics grows, we must turn in new directions to find new drugs effective against resistant infections. Antimicrobial peptides (AMPs) and host-defense peptides (HDPs) are a class of natural products that have been well-studied towards this goal, though very few have found success clinically. However, as there is much known about the behavior of these peptides, work has been done to manipulate their sequences and structures in the search for more drug-like properties. Additionally, novel sequences and structures mimicki
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4

Borrelli, Alexander P. "Synthetic Genes for Antimicrobial Peptides." Digital WPI, 2003. https://digitalcommons.wpi.edu/etd-theses/427.

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The goal of this project was to clone and express the antimicrobial peptide protegrin 1 (PG-1). Initially a yeast system was chosen but was discarded due to technical difficulties. Invitrogen's bacterial T7 expression system was chosen next to express the peptide. PG-1 expression was verified by anti-his immunoblot and then the peptide was purified by IMAC. Its activity was verified using a Bacillus subtillis radial diffusion assay.
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5

Jodoin, Joelle. "Histone H5: Bioinspiration for Novel Antimicrobial Peptides." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36976.

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Modern medicine is challenged continuously by the increasing prevalence of multi-drug resistant bacteria. Therefore, the development of alternatives to traditional antibiotics is an urgent necessity. Cationic antimicrobial peptides (CAMPs) are components of the innate immune defense system. Histones, generally known as proteins that package and regulate the transcription of DNA, share all of the essential antimicrobial traits of CAMPs, and could be promising alternatives to antibiotics. In this study, I investigated the antimicrobial properties of nucleated-erythrocyte-specific linker hist
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6

Kwok, Hoi-shan, and 郭凱珊. "The comparison of biological properties of L- and D-enantiomeric antimicrobial peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206507.

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Antibiotics have been used widely for the treatment of bacterial infections for over half a century. However, the emergence of resistance to antibiotics has aroused public health concern, leading to the development of antimicrobial peptides (AMPs) as potential alternative therapeutic agents against bacterial infections. AMPs are naturally found in many species and have important roles in our innate immune defense systems. AMPs are usually cationic amphipathic peptides with membrane destabilizing property. They have a relatively broad spectrum of antimicrobial activity and pathogens are less li
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7

Linser, Sebastian. "Development of new antimicrobial peptides based on the synthetic peptide NK-2." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982021631.

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8

Ringstad, Lovisa. "Interaction Between Antimicrobial Peptides and Phospholipid Membranes Effects of Peptide Length and Composition /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101989.

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9

Bagheri, Mojtaba [Verfasser]. "Cationic antimicrobial peptides : thermodynamic characterization of peptide-lipid interactions and biological efficacy of surface-tethered peptides / Mojtaba Bagheri." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1025126971/34.

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10

Borelli, Alexander P. "Synthetic genes for antimicrobial peptides." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-102059/.

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11

Vila, Farrés Xavier. "Development of new antimicrobial peptides and peptidomimetics and mechanism of resistance to peptide antibiotics." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285375.

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Nowadays in the world there is a very big problem associated with two factors related to each other. The first factor is the increase in the resistant of certain bacteria, especially the bacteria from the ESKPAE group. The second factor is the dramatically decrease of new antibiotics approved by the FDA. These two problems show that there is an urgent need to find new antibiotics active against these resistant bacteria. In this thesis, we have tackled two different topics closely related in the race to find new antimicrobials. The first topic tackled was the knowledge of the mechanism of re
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12

Gomes, von Borowski Rafael. "Obtention et évaluation de l’activité antibiofilm de peptides et peptidomimétiques issus de Capsicum baccatum var. pendulum (Solanaceae)." Thesis, Rennes 1, 2019. http://www.theses.fr/2019REN1B005.

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Le biofilm confère aux bactéries de nombreux avantages en tant que matrice qui améliore leur résistance et tolérance aux antibiotiques. Staphylococcus epidermidis est l'une des bactéries cliniques les plus importantes en raison de sa capacité à former des biofilms sur des dispositifs médicaux, notamment les stimulateurs cardiaques, les cathéters urinaires et les prothèses. Dans ce contexte, les peptides ont été proposés comme une alternative importante, que ce soit en tant que traitement médicamenteux ou en tant qu’agents de surfaces anti-infectieux. Cette étude porte sur l’identification de n
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13

Strauss, Joshua. "Investigating bacterial lipopolysaccharides and interactions with antimicrobial peptides." Worcester, Mass. : Worcester Polytechnic Institute, 2009. http://www.wpi.edu/Pubs/ETD/Available/etd-012009-120216/.

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14

Wan, Yang. "Synthesis of β,γ-diamino acids and their use to design new analogues of the antimicrobial peptide Gramicidin Septide antimicrobien, la Gramicidine S". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS407/document.

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Dans notre groupe, nous nous intéressons au développement de peptides contenant des acides γ-aminés. Comme d’autres peptides contenant des acides aminés non naturels, ils ont montré leur capacité à posséder des conformations stables et/ou des propriétés biologiques intéressantes. De plus, ces peptides sont généralement résistant à la protéolyse. Dans l’objectif de synthétiser des acides -diaminés sous la forme d’un seul stéréoisomère, nous avons développé une voie de synthèse reposant sur une réaction de Blaise suivie d’une réduction diastéréosélective. En appliquant cette méthode, nous avons
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15

Vargues, Thomas. "Antimicrobial peptides : structure, function and resistance." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4076.

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Higher eukaryotes produce a vast range of antimicrobial peptides (AMPs) that play important roles in their defence against microbial infection. Beta defensins are small (3-5 kDa), cationic peptides that display broad, potent antimicrobial activity against a range of microbes and also act as chemoattractants of important immunomodulatory cells. To generate highly pure peptides for structural and functional studies, we developed a method to prepare recombinant human beta defensin-2 (HBD2). The HBD2 gene was synthesised by recursive PCR with codons optimised for expression in Escherichia coli. HB
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16

Zhao, Hongxia. "Mode of action of antimicrobial peptides." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/zhao/.

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17

Nicolás, Lorenzón Esteban [UNESP]. "Efeito do comprimento e da polaridade do espaçador entre cadeias do peptídeo Hylina-C na forma dimérica." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/88051.

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Made available in DSpace on 2014-06-11T19:23:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-24Bitstream added on 2014-06-13T19:49:48Z : No. of bitstreams: 1 nicolaslorenzon_e_me_araiq.pdf: 1141028 bytes, checksum: 6886093f73fd039fe1ed73b26a3d43dd (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Neste trabalho foi avaliado o efeito da dimerização e do comprimento/polaridade do espaçador utilizado na formação dos dímeros, na estrutura e atividade biológica do peptídeo antimicrobiano: Gly-Trp-Leu-Asp-Val-Ala-Lys-Lys-Ile-Gly-Lys-Ala-Ala-Phe-Asn-Val-
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18

Das, Sanjit. "Methodological development in peptide chemistry for synthesis of antimicrobial and antifungal derivatives of marine natural peptides." Thesis, Perpignan, 2018. http://www.theses.fr/2018PERP0054.

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La chimie de clic est devenue indispensable dans les nombreux domaines de chimie associée à la conception de médicament. Dans ce contexte, comme nous savons(connaissons) l'étude concernant l'impact d'insertion triazole sur la conformation de peptaibol est limitée, nous avons conduit l'étude pour examiner l'impact et l'adaptabilité de 1, 1 4-disubstituted, 2, l'insertion 3-triazole dans peptaibols différent. Selon le résultat de cette expérience touchant à l'activité réduite et la conformation perturbée de l'analogue peptaibol, le substitut dipeptide décoré du fragment triazole portant substitu
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19

Nilebäck, Linnea. "Recombinant spider silk with antimicrobial properties." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102804.

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Immobilizing antimicrobial substances onto biocompatible materials is an important approach for the design of novel, functionalized medical devices. By choosing antimicrobial substances from innate immune systems, the risk for development of resistance in pathogenic microbes is lower than if conventional antibiotics are used. Combining natural antimicrobial peptides and bactericidal enzymes with strong and elastic spider silk through recombinant protein technology would enable large-scale production of materials that could serve as functionalized wound dressings. Herein, fusion proteins with t
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20

Bergsson, Gudmundur. "Antimicrobial polypeptides and lipids as a part of innate defense mechanism of fish and human fetus /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-546-1/.

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21

Díaz, i. Cirac Anna. "Mechanism of action of cyclic antimicrobial peptides." Doctoral thesis, Universitat de Girona, 2011. http://hdl.handle.net/10803/38252.

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This PhD thesis is the result of the combination of experimental and computational techniques with the aim of understanding the mechanism of action of de novo cyclic decapeptides with high antimicrobial activity. By experimental techniques the influence of the replacement of the phenylalanine for tryptophan residue in their antimicrobial activity was tested and the stability in human serum was also analyzed, in order to evaluate their potential therapeutic application as antitumor agents. On the other hand, the interaction amongst the peptide BPC194 c(KKLKKFKKLQ), the best candidate from the
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22

Arranz, Trullén Javier. "Unveiling the multifaceted antimicrobial mechanism of action of human host defence RNases." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400666.

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La presente tesis doctoral se encuentra integrada dentro del estudio a gran escala de la estructura-función de las ribonucleasas antimicrobianas humanas. Estas proteínas catiónicas y de bajo peso molecular son secretadas por la mayoría de los organismos vertebrados agrupándose dentro la superfamilia de la ribonucleasa A, una de las enzimas mejor caracterizadas del siglo XX. De interés remarcable podríamos considerar su amplio abanico de propiedades biológicas, teniendo en cuenta su diverso historial de propiedades biológicas no catalíticas, convirtiéndolas en un buen modelo de proteínas
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23

Morin, Kimberly M. "Cloning and expression of plasmids encoding multimers of antimicrobial peptides indolicidin and PGQ." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0425103-153311.

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24

Lu, Shanshan. "Immobilization of antimicrobial peptides onto titanium surfaces." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12622.

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Prosthetic-associated infections are one of the most challenging postoperative complications for orthopedic implants. The consequences that infections may lead to include patient pain, high cost, prolonged hospitalization time, and usually the revision of the implant. Current prophylaxis and therapy utilizing antibiotics are facing an emergency of increasing bacterial resistance; the design of a novel anti-infectious implant surface is therefore required. Among the potential antimicrobial alternatives are the antimicrobial peptides (AMP). AMPs are a family of natural defense peptides that has
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25

Bunkóczi, Gábor. "Structure determination of peptides with antimicrobial action." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974033650.

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26

Neville, Frances Clare. "Interaction of antimicrobial peptides with bacterial membranes." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439597.

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27

Chau, Tanguy. "Delivery, design, and mechanism of antimicrobial peptides." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62063.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Each year, 2 million people contract hospital-acquired bacterial infections, which causes the death of 100,000 patients and costs the US healthcare system over $21 billion. These infections have become dangerously resistant to our existing line of antibiotics and are rapidly spreading outside of hospitals and into communities. As molecular targets to develop new antibiotics are becoming exhausted, clinicians and scienti
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28

Franzman, Michael Ryan. "Targeted antimicrobial activity of SMAP28 conjugated to IgG antibody." Thesis, University of Iowa, 2007. http://ir.uiowa.edu/etd/140.

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29

Tollin, Maria. "Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-270-5/.

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30

HORA, Gabriel Costa Alverni da. "Simulações computacionais do peptídeo híbrido Plantaricina-Pediocina em membranas fosfolipídicas puras e binárias compostas por POPC: POPG." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18337.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-02-16T14:50:28Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Thesis_Gabriel_digital.final.pdf: 10412972 bytes, checksum: ec85b3671bb5bbcd735ea9e83436b08f (MD5)<br>Made available in DSpace on 2017-02-16T14:50:28Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Thesis_Gabriel_digital.final.pdf: 10412972 bytes, checksum: ec85b3671bb5bbcd735ea9e83436b08f (MD5) Previous issue date: 2016-04-01<br>CNPq<br>Peptídeos antim
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31

Dannehl, Claudia. "Fragments of the human antimicrobial LL-37 and their interaction with model membranes." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6814/.

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A detailed description of the characteristics of antimicrobial peptides (AMPs) is highly demanded, since the resistance against traditional antibiotics is an emerging problem in medicine. They are part of the innate immune system in every organism, and they are very efficient in the protection against bacteria, viruses, fungi and even cancer cells. Their advantage is that their target is the cell membrane, in contrast to antibiotics which disturb the metabolism of the respective cell type. This allows AMPs to be more active and faster. The lack of an efficient therapy for some cancer types and
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32

Arouri, Ahmad. "Interaction of antimicrobial peptides with model lipid membranes." kostenfrei, 2009. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-540.

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33

SOLLAMI, DELEKTA SZYMON. "Hexosomes as Drug Delivery Vehicles for Antimicrobial Peptides." Thesis, KTH, Skolan för kemivetenskap (CHE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-172360.

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This master thesis project was carried out at SP Technical Research Institute of Sweden within the FORMAMP project which goal is to increase the efficiency and stability of antimicrobial peptides (AMPs) by exploring and developing a number of innovative formulation strategies for the drug delivery of those systems. In view of the growing problem of bacterial resistance to traditional antibiotics, AMPs represent one of the most promising alternatives as therapeutics against infectious diseases: besides having a fast and non-specific mechanism of action, they are less prone to bacterial resistan
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34

Warfield, Rachel. "Internally quenched peptides as substrates for antimicrobial enzymes." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436725.

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35

Loose, Christopher (Christopher R. ). "The production, design and application of antimicrobial peptides." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38969.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2007.<br>Includes bibliographical references (p. 248-268).<br>With the spread of drug-resistant bacteria, existing antibiotics are losing their potency. Antimicrobial peptides (AmPs) represent an exciting class of drug candidates, particularly because their mechanism of action is unlikely to induce drug resistance. If resistance to AmPs were also slower to emerge in the clinic, they would have longer useful lifetimes than existing antibiotics. Nevertheless, a number of limitations exist for AmPs in the clini
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36

Okechuku, Adaora. "Determination of the mode of action of the antibacterial peptide ApoEdp." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/determination-of-the-mode-of-action-of-the-antibacterial-peptide-apoedp(1937bcc4-f28b-416e-8dd7-8d493082ac2a).html.

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The emergence of multidrug resistant strains of bacteria has resulted in the need for novel therapeutic agents. The ApoEdp peptide, derived from the receptor-binding region of the human apolipoprotein E, had previously been shown to have activity against herpes simplex viruses, human immunodeficiency virus and certain bacterial species. However, its antibacterial mode of action was not elucidated, therefore the present study aimed to determine this mechanism. The susceptibility of several different strains, including Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium smegmatis, Staph
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37

Lorenzón, Esteban Nicolás. "Efeito do comprimento e da polaridade do espaçador entre cadeias do peptídeo Hylina-C na forma dimérica /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/88051.

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Orientador: Eduardo Maffud Cillli<br>Banca: Ana Marisa Fusco Almeida<br>Banca: Vani Xavier de Oliveira Júnior<br>Resumo: Neste trabalho foi avaliado o efeito da dimerização e do comprimento/polaridade do espaçador utilizado na formação dos dímeros, na estrutura e atividade biológica do peptídeo antimicrobiano: Gly-Trp-Leu-Asp-Val-Ala-Lys-Lys-Ile-Gly-Lys-Ala-Ala-Phe-Asn-Val-Ala-Lys-Asn-Phe-Leu-CONH2. Nesse sentido, o monômero e três dímeros com diferentes espaçadores foram sintetizados pelo método de síntese de peptídeo em fase sólida (SPFS) utilizando uma combinação das químicas Fmoc e Boc. An
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Dallon, Emma Kay. "Exploration of Antimicrobial Activity in Natural Peptides and High-Throughput Discovery of Synthetic Peptides." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7468.

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Despite many medical advances, antibiotic resistant bacteria increasingly plague the modern world, necessitating discovery of new antibiotics. One area of nature that can provide inspiration for antibiotics is antimicrobial peptides. Many of these peptides exist in nature, with some classes that have not been studied or characterized well. One such class is the defensin-like peptides generated by the plant Medicago truncatula as part of their symbiotic relationship with Sinorhizobium meliloti. Nodule-specific Cysteine Rich (NCR) peptides are defined by the presence of multiple cysteines, and r
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Güell, Costa Imma. "Synthesis of antimicrobial peptides derived from BP100 and BPC194." Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/69920.

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In the present PhD thesis we studied the solid-phase peptide synthesis of antimicrobial peptides derived from the lead peptides BP100 and BPC194. First, peptides derived from BP100 containing D-amino acids at different positions of the sequences were prepared. Moreover, peptidotriazoles derived from BP100 were also synthesized containing the triazole ring at the side-chain of different amino acids. Then, we proceeded to perform studies for the synthesis of multivalent peptides derived from BPC194. To achieve this objective, the synthesis of cyclic peptides containig a triazole ring at amino ac
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40

Termén, Stefan. "Expression of cathelicidin antimicrobial peptides in man and rat /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-138-5/.

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41

Shewring, Dawn M. "Fish antimicrobial peptides and the indentification of gadoid cathelicidins." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604.

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With the culture of marine fish species increasing, interest in ways to combat infection in these species has grown. One such avenue is the search for novel antimicrobials. Antimicrobial peptides (AMPs) are host derived molecules with a significant role in innate immune responses and have been studied extensively in mammals. Well known AMP families include β-defensins, cathelicidins, liver expressed antimicrobial peptides and, specific to fish, the piscidins. While these molecules have been found in some fish species mining of expressed sequence tag (EST) databases was carried out to identify
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42

Zhang, Ruowen. "Isolation and analysis of antimicrobial peptides from frog skins." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534592.

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Morgan, Michelle Marie. "Interaction of Burkholderia cepacia complex organisms and antimicrobial peptides." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540768.

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44

McQuade, Rebecca. "Clostridium difficile Responds to Antimicrobial Peptides and Oxidative Stress." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578613.

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Clostridium difficile (CD) is the leading cause of bacterial hospital-associated infection in North America. How CD colonizes the human host, including its response to the innate immune system and other stresses, is poorly understood. This work considers CD's defenses against two stresses found in the host - the antimicrobial peptide LL-37 and reactive oxygen species (ROS). LL-37 had bactericidal activity against CD. CD strains varied in their sensitivity to the peptide, and epidemic-associated strains were more resistant to LL-37 than others. CD became more resistant to LL-37 following exposu
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45

van, Rensburg Wilma. "Characterization of natural antimicrobial peptides adsorbed to different matrices." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97929.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Biofouling is the attachment and biofilm formation that leads to negative repercussions such as persistent post-harvest infections, infections obtained from medical implants and continual surface contamination of food processing plants. Much of the problem lies with the resistance that develops against conventional treatments due to the formation of mature biofilms. Thus the focus has shifted from the removal of biofilms to the prevention of initial attachment of organisms. This entails the use of antimicrobial surfaces tha
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46

Alkassem, Hasan. "Imaging antimicrobial peptides in action by atomic force microscopy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10043141/.

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Antimicrobial resistance is a challenge facing the world in the twenty-first century with an estimated 10 million deaths by 2050 if no actions are taken. Microbial resistance to drugs is a natural consequence when bacteria develop and adapt genetically to face new challenges including antibiotics. Currently, this development occurs at a higher rate than drug discovery. Hence there is a need for a new generation of antibiotics that kill pathogenic bacteria. Nature itself provides inspiration for such new antibiotics. For example, our immune system secretes antimicrobial peptides (AMPs), which h
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47

Bell, Stephanie. "Antimicrobial peptide gene expression in human tonsils." Thesis, University of Newcastle upon Tyne, 2009. http://hdl.handle.net/10443/3589.

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The human palatine tonsils play important roles in host immunity and provide a barrier against invading pathogens. However the Gram-positive bacterium, Streptococcus pyogenes often penetrates their defences. This results in tonsillitis, in which sufferers present with swollen and painful palatine tonsils. Moreover tonsillitis is often recurrent. Despite tonsillitis being relatively common, the immunological factors that allow this infection to perpetuate remain obscure. Antimicrobial peptides (AMPs), expressed at epithelial and mucosal surfaces, provide a first-line of defence against potentia
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48

Montanha, Érica Azzolino. "Efeitos da dimerização e modificações na porção N-terminal do peptídeo antimicrobiano Aureína 1.2 em sua interação com filmes de Langmuir e atividade biológica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-06012017-115404/.

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Filmes de Langmuir são usados como modelos simplificados de membranas celulares, cujas propriedades podem ser correlacionadas com efeitos fisiológicos de moléculas de interesse biológico, como os peptídeos antimicrobianos (PAMs). Nesta dissertação investigamos a interação do peptídeo Aureína 1.2, na forma de monômero (AU), dímero ((AU)2K) e com variações na porção N-terminal (KAU e DAU), com filmes de Langmuir obtidos do extrato lipídico da bactéria Escherichia coli. Todos os peptídeos injetados em concentrações de 20 a 200nM se incorporaram ao filme de Langmuir, causando expansão nas isoterma
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49

GAZZANEO, Luiz Rodrigo Saldanha. "Expressão heteróloga da defensina dehys de euphorbia hyssopifolia 32 em E. coli." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/19523.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-07-12T14:29:17Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Tese_Gazzaneo (Biblioteca Central).pdf: 2832068 bytes, checksum: bb29fc38317d9f60a0d6129655b9b7a1 (MD5)<br>Made available in DSpace on 2017-07-12T14:29:17Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Tese_Gazzaneo (Biblioteca Central).pdf: 2832068 bytes, checksum: bb29fc38317d9f60a0d6129655b9b7a1 (MD5) Previous issue date: 2016-03-14<br>Defensinas são
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50

Felek, Arif. "Discovery of antimicrobial peptides active against antibiotic resistant bacterial pathogens." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/discovery-of-antimicrobial-peptides-active-against-antibiotic-resistant-bacterial-pathogens(cc408f16-e24a-4f49-ac8e-e7a5fe7185d0).html.

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Rapid development of antimicrobial resistance (AMR) among bacteria, combined with diminished new antibiotic discovery rates, is an increasing threat to human health. Bacterially derived antimicrobial peptides (AMP) hold excellent potential as potent novel therapeutics. This study embraces traditional natural AMP discovery methods and the newer in silico genome mining tool BAGEL 3 to facilitate identification of novel antimicrobial agents. The traditional screening efforts led to the discovery of two promising antimicrobial producer strains; Bacillus pumilus J1 producing two AMPs, peptides NI03
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