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Dissertations / Theses on the topic 'Antimicrobial proteins'

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Published: 4 June 2021
Last updated: 27 July 2025

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1

Berhane, Nahom Ahferom. "Antimicrobial Proteins for Human Health." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37283.

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Bacteria are one of the largest causes of human disease, with millions of deaths every year attributed to bacterial infections, and they have become more difficult to tackle with the widespread emergence of antibiotic resistance. In this thesis, I describe my studies that pursued two approaches: one focus was on using antimicrobial histones as an alternative to treatment for antibiotic resistant bacteria; in another approach the recombinant version of an eggshell cuticle protein was expressed and purified for testing against food-safety pathogens. One major pathogen that is contributing to t
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2

Tan, Yu Pei. "The development of Lactococcus lactis as an antimicrobial agent." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/39143/1/Yu_Pei_Tan_Thesis.pdf.

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Non-pathogenic lactic acid bacteria are economically important Gram-positive bacteria used extensively in the food industry. Due to their “generally regarded as safe” status, certain species from the genera Lactobacillus and Lactococcus are also considered desirable as candidates for the production and secretion of recombinant proteins, particular those with therapeutic applications. The hypothesis examined by this thesis is that Lactococcus lactis can be modified to be an effective antimicrobial agent. Therefore, the aims of this thesis were to investigate the optimisation of the express
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Eilers, Björn. "Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16023.

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Shigella flexneri verursacht im Verlauf der Infektion eine massive Enzündungsreaktion sowie Schädigung des humanen Darmepithels. Neutrophile sind die ersten Zellen des angeborenen Immunsystems, welche den Infektionsherd infiltrieren. Diese Zellen greifen Mikroorganismen mittels Phagozytose, Neutrophiler extrazellulärer Fallen (Neutrophil Extracellular Traps, NETs) oder Degranulierung an. In dieser Arbeit haben wir untersucht, wie die Degranulierung von Neutrophilen die Virulenz von Shigellen beeinflußt und konnten zeigen, dass die Exposition von Shigellen mit Proteinen aus den Granula von Neut
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4

Salazar, Montoya Vivian Angélica. "Exploring the mechanism of action of human antimicrobial ribonucleases." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/310611.

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Las ribonucleases humanas son un grupo heterogéneo de proteínas pertenecientes a la superfamilia de la Ribonucleasa A. Estas proteínas se caracterizan por su capacidad de hidrolizar ácidos ribonucleicos y por la presencia de actividad antimicrobiana frente diversos organismos patógenos como bacterias, hongos, parásitos y virus. El primer objetivo del presente estudio doctoral se centra en la caracterización de la actividad antimicrobiana y en modelos de membrana de las formas nativas de la ribonucleasa 3 purificadas a partir de eosinófilos. Las distintas formas nativas presentan modific
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5

Scott, Aaron. "Functional studies of the human antimicrobial proteins LL-37 and Eppin." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546424.

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6

Al-Mashikhi, Shalan Alwan Edan. "Separation of antimicrobial protein fractions from animal resources for potential use in infant feeding." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26948.

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In the first part of this study, a non-ferric method for selective elimination of β-lactoglobulin from cheese whey was investigated. A new method was developed based on hexametaphosphate treatment of cheese whey. When Cheddar cheese whey was treated under the optimized conditions, i.e., 1.33 mg/mL sodium hexametaphosphate at 22°C and pH 4.07 for 1 hr, more than 80% of β-lactoglobulin was removed by precipitation. Almost all of the immunoglobulins and the major portion of α-lactalbumin were retained in the supernatant as indicated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SD
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7

FASOLI, Anna. "Biophysical mechanisms of membrane perturbation and signal transduction produced by proteins and peptides." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2388995.

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My primary research interest is focused on the field of cellular electrical activity, ranging from the ion channels that generates it, up to the study of intracellular processes regulating it, and new generation of drugs. For this purpose, during my Ph.D. I have learnt and improved different cutting-edge techniques, i.e. the patch-clamp technique, the fluorescence imaging, and the synthesis and use of model membranes. Moreover, to explore particular aspects of these molecular mechanisms and to overcome the issues raised during the investigations, non-conventional strategies were employed, even
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8

Roca, Pinilla Ramon. "Development of a new generation of antimicrobial proteins based on a versatile nanoparticulated format and multidomain structure." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670790.

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Durant la major part de la historia humana, els patògens han estat una de les principals causes de morts i malalties. Gràcies al descobriment dels antibiòtics hem aconseguit tractar aquestes malalties amb facilitat, però el seu mal ús ha accelerat l’aparició de resistències als antimicrobians (AMRs). Atès que les AMRs han provocat que la majoria de fàrmacs antimicrobians siguin ineficaços, el desenvolupament de tractaments alternatius és mes necessari que mai. Els pèptids de la defensa del hoste (HDPs) han estat proposats com a models per la generació de nous antimicrobians per lluitar contra
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9

Duncan, Melanie Laura. "The Final Hurdle: The role of envelope proteins in poxvirus release." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25858.

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Increasing incidence of antimicrobial resistance requires identification of novel drugs, and the human genome presents thousands of potential targets. Intracellular pathogens rely on host proteins and pathways during their entry, replication and egress. Poxviruses are reliant on host Abl tyrosine kinases for release of enveloped virus, the last step in their egress. Release can be inhibited by Abl kinase targeting drug imatinib, with treatment shown to rescue mice infected with a lethal dose of vaccinia virus (VACV). It is speculated that host-targeted antimicrobials are less likely to sele
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10

Oguejiofor, Wilson. "Investigating the delivery of antimicrobial proteins and aminoglycoside antibiotics to the airways." Thesis, Aston University, 2013. http://publications.aston.ac.uk/20895/.

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Biopharmaceuticals are finding wide applications in the management of diverse disease conditions. Pulmonary delivery of proteins may constitute an effective and efficient non-invasive alternative to parenteral delivery, which is currently the main route of administration of biopharmaceutical drugs. A particular area, in which pulmonary delivery of peptides and proteins may find ready application, is in the local delivery of antimicrobial peptides and proteins to the airway, a measure that could potentially bring about improvements to currently available antipseudomonal therapies. This thesis h
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11

Tollin, Maria. "Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-270-5/.

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12

Cunden, Lisa Stephanie. "A molecular investigation of the antimicrobial functions of the human S100 host-defense proteins." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121779.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>The human host is continually exposed to potentially harmful organisms and the innate immune response is the first line of defense against microbial invasion. One strategy employed by the human innate immune system includes the release of antimicrobial host-defense proteins (HDPs). The goal of this thesis is to understand the antimicrobial functions of four host-defense proteins of the S100 family of proteins: calprotecti
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13

Kaye, Elena Cortizas. "The Function of Outer Membrane Protein A (OmpA) in Yersinia pestis." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/58.

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The outer membrane protein OmpA is one of the major outer membrane proteins in many species of bacteria, including the Yersiniae. Our goal was to explore the role of OmpA in Y. pestis. This encompasses the ability of Yersinia to infect and survive within macrophages, as well as to resist antimicrobial compounds. Our laboratory found that a delta ompA mutant is impaired in a macrophage-associated infectivity assay. We also found that OmpA might play a role in the ability of the bacteria to resist antimicrobial peptides, specifically polymyxin B. Aditionally, we assessed the differences in OmpA
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14

Miyazawa, Naoki. "Atomic and electronic analysis of interactions between nanoporous Auand proteins." Kyoto University, 2019. http://hdl.handle.net/2433/242319.

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15

Brumini, Diana. "Investigation on donkey milk protein fractions: in vitro antimicrobial, antiviral and anti-proliferative activities and casein separation by cation exchange chromatography." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1273.

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This thesis was aimed to study donkey milk protein fractions and their biological properties. In the first Chapter the donkey¡¯s milk gross composition and the related hygienic-sanitary aspects are introduced. The main use of donkey milk in human nutrition, especially in infancy and in patients with cow milk protein allergy (CMPA), is also discussed. The second Chapter ¡°Antimicrobial compounds in milk¡± was drafted after an intensive course at the University of Copenhagen: ¡°Functional milk compound ¨C with focus on milk proteins¡±, and presented as the final report of the first year of Ph
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16

Hinds, Vaughan Nichole. "Antibacterial Proteins and Peptides in Nurse Shark (Ginglymostoma Cirratum) Peripheral Blood Leukocytes." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/369.

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In many vertebrate and invertebrate species mediators of innate immunity include antimicrobial peptides (AMPs) such as peptide fragments of histones and other proteins with previously ascribed different functions. Shark AMPs have not been described and this research examines the antibacterial activity of nurse shark (Ginglymostoma cirratum) peripheral blood leukocyte lysates. Screening of lysates prepared by homogenizing unstimulated peripheral blood leukocytes identified muramidase (lysozyme-like) and non-muramidase antibacterial activity. Lysates were tested for lysozyme using the lysoplat
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17

Mody, Shreena Himanshu. "The Antimicrobial Properties of Honey and Their Effect on Pathogenic Bacteria." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7042.

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Honey has been used to heal wounds since ancient times. There are many references in ancient literature that cite honey for its medicinal uses. It is used as an alternative agent to cure infections of wounds, burns, ulcers etc. Researchers have shown some of the antimicrobial properties of honey when used as an ointment. When applied to an affected area, it helps to promote the growth of healthy tissue. One of the factors on which the quality of the honey depends, is its geographical origin. Based on the location, honey types can vary as much as 100-fold from each other in color, aroma, viscos
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18

Ballottin, Daniela Pott Marinho 1987. "Caracterização de nanopartículas de prata e sua aplicação na produção de tecidos antimicrobianos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248431.

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Orientadores: Ljubica Tasic, Priscyla Daniely Marcato Gaspari<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-25T19:45:44Z (GMT). No. of bitstreams: 1 Ballottin_DanielaPottMarinho_D.pdf: 4687735 bytes, checksum: 78a932e6ae81a2c4a51ae94b6bf0c65f (MD5) Previous issue date: 2014<br>Resumo: Esta tese compreende a produção biogênica e extracelular de nanopartículas de prata (AgNP) utilizando o fungo Fusarium oxysporum, a caracterização físico-química e bioquímica de AgNP e de proteínas, respectivamente. As partículas obtidas for
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19

Furlan, Michela. "Activity of salmonid antibacterial proteins and regulation of their expression in response to pathogens." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10146.

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2012/2013<br>Cathelicidins are an important family of antimicrobial peptides involved in the innate immune system and have been discovered quite recently in teleost. Differently from the well-studied mammal cathelicidins, information about their structural and functional characteristics and the tissue expression and localization are yet scattered or inconsistent in fish and in particular in salmonids. The present work highlights some characteristics of salmonid cathelicidins. Results indicate that fragments of the C-terminal domain own a wide-spectrum, salt-sensitive antibacterial activity es
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20

Wu, Qiong. "Biofoams and Biocomposites based on Wheat Gluten Proteins." Doctoral thesis, KTH, Fiber- och polymerteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207778.

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Novel uses of wheat gluten (WG) proteins, obtained e.g. as a coproduct from bio-ethanol production, are presented in this thesis. A flame-retardant foam was prepared via in-situ polymerization of hydrolyzed tetraethyl orthosilicate (TEOS) in a denatured WG matrix (Paper I). The TEOS formed a well-dispersed silica phase in the walls of the foam. With silica contents ≥ 6.7 wt%, the foams showed excellent fire resistance. An aspect of the bio-based foams was their high sensitivity to fungi and bacterial growth. This was addressed in Paper II using a natural antimicrobial agent Lanasol. In the sam
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21

Korir, Daniel Kiplangat. "Design, Synthesis and Characterization of Polymer and Protein Coated Hybrid Nanomaterials: Investigation of Prototypes for Antimicrobial and Anticancer Applications." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505197/.

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This work involves synthesis and characterization of isotropic and anisotropic noble metal nanoparticles for applications ranging from antimicrobial uses to anticancer applications. These nanomaterials are stabilized in genuinely benign biomaterials ranging from polymers to cross linked proteins for targeted cancer treatments. The nanoparticles are found to have tunable optical properties.
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22

Balaguer, Grimaldo María de la Paz. "Development of active bioplastics based on wheat proteins and natural antimicrobials for food packaging applications." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/48520.

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This PhD dissertation focuses on the development of renewable and biodegradable active films based on chemically-modified wheat gliadin proteins endowed with antimicrobial capacity owing to the incorporation of naturally-occurring bioactive compounds, namely cinnamaldehyde, natamycin, and lysozyme. Gliadin proteins were treated with cinnamaldehyde at acidic pH and films were produced by casting. The resulting protein-based films presented improved functional properties (mechanical, barrier, and water resistance), and biochemical evidence of the formation of a more compact network whos
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23

Ruiz, González Rubén. "New strategies in antimicrobial photodynamic therapy and singlet oxygen detection." Doctoral thesis, Universitat Ramon Llull, 2013. http://hdl.handle.net/10803/119556.

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Tres estratègies adreçades a aportar una major perspectiva en el camp de la teràpia fotodinámica antimicrobiana comprenen la primera part de la tesi. En una primera aproximació, sis fotosensibilitzadors catiònics, amb diferent càrrega elèctrica neta i estructura, han estat caracteritzats en dissolució i les seves propietats fotoinactivadores provades contra diferents tipus de microorganismes. En una segona aproximació, conjugats entre un fotosensibilitzador i el pèptid antimicrobià Apidaecina 1b han estat analitzats fotofísica i mecanísticament, i les seves propietats correlacionades amb la se
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24

Baron, Olga. "Functional analysis of lipopolysaccharide binding proteins/Bactericidal permeability increasing proteins in immune responses of the freshwater snail, Biomphalaria glabrata." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ016.

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Les LBP/BPIs sont des protéines importantes de la réponse antimicrobienne des mammifères, encore mal caractérisées chez les invertébrés. L'objectif de ce projet était d'élucider le rôle des LBP/BPIs dans la réponse immunitaire du gastéropode B. glabrata. Nous avons montré que l'une des LBP/BPI (BgLBP/BPI1) était une protéine majeure de la glande albumène et des masses d'oeufs et possédait les activités attendues des BPIs telle que la capacité de perméabilisation des bactéries.De plus, nous avons découvert une nouvelle activité biocide (anti-oomycète) inconnue jusqu'alors chez les LBP/BPI, et d
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25

Carratalá, Tomás Jose Vicente. "Development and characterization of protein nanoformulations as alternative therapeutics to reduce antibiotic usage." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673321.

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L’aparició de farmacoresistència bacteriana als antibiòtics convencionals és una situació d’alarma mundial. Aquest escenari ha obligat a implementar mesures com la millora de les pràctiques d’higiene o l’administració controlada d’antibiòtics per reduir el seu ús en totes les àrees en les que s’utilitzen comunament, inclosa la medicina humana i animal i la indústria animal de producció d’aliments . Totes aquestes mesures estan destinades a disminuir l’aparició i propagació de la resistència als antibiòtics entre els bacteris, però quan es tracta de combatre als bacteris que ja presenten una o
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26

Farias, Davi Felipe. "ProteÃnas de sementes de Amburama Cearensis (Allemao) A. C. Smith: Valor Nutricional e bioatividade contra patÃgenos e vetores de doenÃas." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8090.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Amburana cearensis (Allemao) A. C. Smith, usually known in portuguese language as âImburana-de-Cheiroâ or âCumaruâ, is a leguminous tree, subfamily Papilionoideae with common occurrence in âCaatingaâ Dominium. Despite the numerous ethnobotanical uses, few studies report biological activities of medical interest and / or agribusiness for this species or yet its utilization as food for humans and / or animals. This study aimed to evaluate the proteins of A. cearensis on its nutritional value associated with its biochemical characteri
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27

Toillier, Sandra Luisa. "Controle de crestamento bacteriano comum (Xanthomonas axonopodis pv. phaseoli) e alterações bioquímicas em feijoeiro induzidas por Pycnoporus sanguineus." Universidade Estadual do Oeste do Paraná, 2008. http://tede.unioeste.br:8080/tede/handle/tede/1341.

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Made available in DSpace on 2017-07-10T17:37:26Z (GMT). No. of bitstreams: 1 Sandra Luisa Toillier.pdf: 545173 bytes, checksum: 7cdf4b17689b7059b1098820885d4e6c (MD5) Previous issue date: 2008-08-01<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Bean (Phaseolus vulgaris) is among one of the main Brazilian crops and can be affected by several diseases, such as common bacterial blight caused by Xanthomonas axonopodis pv. phaseoli. The study of this interaction can contribute to development of alternative methods to control this disease. The aim of this work was to verify t
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Salles, Sara Salomão. "Prospecção in silico de novos peptídeos antimicrobianos a partir de fragmentos proteolíticos de leite bovino." Universidade Federal de Juiz de Fora, 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/1723.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-06-29T12:36:04Z No. of bitstreams: 1 sarasalomaosalles.pdf: 1082471 bytes, checksum: d6da8553ca94e46e9009c917347d9549 (MD5)<br>Approved for entry into archive by Diamantino Mayra (mayra.diamantino@ufjf.edu.br) on 2016-07-05T14:46:27Z (GMT) No. of bitstreams: 1 sarasalomaosalles.pdf: 1082471 bytes, checksum: d6da8553ca94e46e9009c917347d9549 (MD5)<br>Made available in DSpace on 2016-07-05T14:46:28Z (GMT). No. of bitstreams: 1 sarasalomaosalles.pdf: 1082471 bytes, checksum: d6da8553ca94e46e9009c917347d9549 (MD5) Previous issue date:
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Fernandes, GeÃrgia Sampaio. "ProspecÃÃo nutricional e bioativa de sementes de dez espÃcies vegetais da caatinga." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7681.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A Caatinga possui uma vegetaÃÃo heterogÃnea cuja biodiversidade taxonÃmica conta com mais de 2.000 espÃcies de plantas. Dentre essas, cerca de 220 pertencem à famÃlia das leguminosas com 80 espÃcies endÃmicas, Ãnicas desse bioma. Muitas sÃo usadas para diversas finalidades de forma indiscriminada, reduzindo consideravelmente a diversidade e o nÃmero de espÃcies antes mesmo do conhecimento de suas potencialidades. Estudos que possam agregar valor econÃmico e viabilizar o uso racional, sustentÃvel e a conservaÃÃo das mesmas, aliada Ã
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Lourenço, Anete Pedro. "Genes codificadores dos peptídeos antimicrobianos e de outras proteínas envolvidas na resposta imune de in Apis mellifera." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-04042008-144240/.

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Os insetos desenvolveram um sistema imune eficiente contra parasitas e patógenos, que compreende a resposta celular e a humoral. Os mecanismos celulares envolvem a fagocitose e a encapsulação pelos hemócitos, enquanto que as respostas humorais incluem a ativação da Profenoloxidase, e a síntese pelo corpo gorduroso dos peptídeos antimicrobianos, que são liberados na hemolinfa. Duas vias de sinalização intracelular, Toll e Imd, controlam a expressão dos genes codificadores dos peptídeos antimicrobianos. A análise do Genoma da abelha Apis mellifera permitiu a identificação dos genes dessas vias.
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Borge-Renberg, Karin. "Communicate or die : signalling in Drosophila immunity." Doctoral thesis, Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1817.

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Surasombatpattana, Pornapat. "Transmission du virus de la dengue : rôle de la salive d’Aedes aegypti." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20210.

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Lors de la prise d'un repas sanguin par le moustique Aedes (Ae) aegypti, le virus de la dengue (DENV) est transmis à l'homme avec la salive du moustique. Ce mélange complexe est en partie déposé dans le compartiment cutané extravasculaire lors de la piqûre de moustique. Il est donc important de prendre en compte la triade virus-vecteur-hôte vertébré dans les mécanismes de transmission de ce virus à l'hôte vertébré. Des analyses de génomique et protéomique des glandes salivaires d'Ae. Aegypti infectées ou non par le DENV nous ont permis de mettre en évidence dans les glandes salivaires de moust
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Parton, Daniel L. "Pushing the boundaries : molecular dynamics simulations of complex biological membranes." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:7ab91b51-a5ae-46b4-b6dc-3f0dd3f0b477.

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A range of simulations have been conducted to investigate the behaviour of a diverse set of complex biological membrane systems. The processes of interest have required simulations over extended time and length scales, but without sacrifice of molecular detail. For this reason, the primary technique used has been coarse-grained molecular dynamics (CG MD) simulations, in which small groups of atoms are combined into lower-resolution CG particles. The increased computational efficiency of this technique has allowed simulations with time scales of microseconds, and length scales of hundreds of nm
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Alves, Cristina Jansen. "Microencapsulação de própolis utilizando matrizes proteicas para aplicação como ingrediente funcional em alimentos." Universidade Federal de Pelotas, 2018. http://guaiaca.ufpel.edu.br:8080/handle/prefix/4131.

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Corrales, Jone. "Antimicrobial Polypeptides, Piscidins and Histone-Like Proteins, in Important Aquacultured Fish and the Effect of Nutrition on their Expression and Susceptibility to Infection in Hybrid Striped (Sunshine) Bass (Morone saxatilis â x M. chrysops â)." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-05052008-171103/.

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Innate immunity is the initial response of a host in defending against pathogen invasion (Beutler 2004, Janeway and Medzhitov 2002). The key features of an innate immune response are that it is: non-specific (broad-spectrum), rapid (often within minutes to hours) and conserved in its pattern of recognition. Antimicrobial polypeptides (AMPP) are a key component of the innate system and present in virtually all life forms (Zasloff 2002). One of the most widespread AMPP in fish are the piscidins. Piscidins have potent, broad-spectrum activity against viruses (Chinchar et al 2004), bacteria (Silph
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36

López, Marcos Alejandro Sulca. "Desenvolvimento de novos peptídeos antimicrobianos a partir de proteínas dos venenos das serpentes peruana Bothrops pictus e Bothriopsis oligolepis." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11042017-083735/.

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A resistência aos antibióticos adquirida por micro-organismos patogênicos é um problema de saúde mundial e, por isso, o desenvolvimento de novos agentes antimicrobianos vem sendo amplamente estimulado. Sabendo que muitos peptídeos bioativos correspondem a fragmentos peptídicos de proteínas e/ou seus análogos, este trabalho teve o objetivo de desenvolver novos peptídeos antimicrobianos (AMPs) a partir das sequências aminoacídicas e das estruturas 3D de proteínas possivelmente envolvidas na atividade antimicrobiana de venenos de serpentes pouco estudados. As etapas iniciais seguidas foram: a) es
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37

Borrelli, Alexander P. "Synthetic Genes for Antimicrobial Peptides." Digital WPI, 2003. https://digitalcommons.wpi.edu/etd-theses/427.

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The goal of this project was to clone and express the antimicrobial peptide protegrin 1 (PG-1). Initially a yeast system was chosen but was discarded due to technical difficulties. Invitrogen's bacterial T7 expression system was chosen next to express the peptide. PG-1 expression was verified by anti-his immunoblot and then the peptide was purified by IMAC. Its activity was verified using a Bacillus subtillis radial diffusion assay.
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38

GAZZANEO, Luiz Rodrigo Saldanha. "Expressão heteróloga da defensina dehys de euphorbia hyssopifolia 32 em E. coli." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/19523.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-07-12T14:29:17Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Tese_Gazzaneo (Biblioteca Central).pdf: 2832068 bytes, checksum: bb29fc38317d9f60a0d6129655b9b7a1 (MD5)<br>Made available in DSpace on 2017-07-12T14:29:17Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Tese_Gazzaneo (Biblioteca Central).pdf: 2832068 bytes, checksum: bb29fc38317d9f60a0d6129655b9b7a1 (MD5) Previous issue date: 2016-03-14<br>Defensinas são
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39

Borelli, Alexander P. "Synthetic genes for antimicrobial peptides." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-102059/.

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40

Wallock-Richards, Daynea Juaneckah. "Natural products : biosynthesis, antimicrobial properties and protein targets." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/14188.

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The diversity of biosynthetic pathways in prokaryotes and eukaryotes has led to numerous bioactive natural products (NPs) which occupy a vast chemical space. Despite the current challenges in NP research, these molecules are still relevant today as they are a major source of human medicine as well as being useful biological tools. The elucidation of their biosynthetic pathways has also provided information about the biochemical and biophysical properties of fascinating enzyme families such as the α- oxoamine synthases (AOSs). The AOSs are an expanding group of pyridoxal 5’- phosphate (PLP)-dep
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41

SOUZA, Renata Silva Cabral de. "Avalia??o do potencial antioxidante e antimicrobiano de prote?nas do soro de leite concentradas por membranas e hidrolisadas por diferentes enzimas comerciais." Universidade Federal Rural do Rio de Janeiro, 2013. https://tede.ufrrj.br/jspui/handle/jspui/2534.

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Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-11-29T17:12:51Z No. of bitstreams: 1 2013 - Renata Silva Cabral de Souza.pdf: 1753830 bytes, checksum: 2dff8752eb3f7974e34f8809d059f126 (MD5)<br>Made available in DSpace on 2018-11-29T17:12:51Z (GMT). No. of bitstreams: 1 2013 - Renata Silva Cabral de Souza.pdf: 1753830 bytes, checksum: 2dff8752eb3f7974e34f8809d059f126 (MD5) Previous issue date: 2013-05-23<br>CAPES<br>The aim of this study was to evaluate the process of protein concentration in bovine whey proteins by ultrafiltration process and subsequently the protein hydrolysate obt
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42

Karlsson, Jenny. "Regulation and characterization of antimicrobial peptides in man and mice /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-286-6/.

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43

Silva, Carolina Moroni. "Atividade antioxidante e antimicrobiana apresentada por hidrolisados enzimáticos obtidos de subprodutos da corvina (Micropogonias furnieri)." reponame:Repositório Institucional da FURG, 2014. http://repositorio.furg.br/handle/1/6078.

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Submitted by Raquel Vergara Gondran (raquelvergara38@yahoo.com.br) on 2016-04-27T00:16:18Z No. of bitstreams: 1 carolina moroni - atividade antioxidante e antimicrobiana apresentada por hidrolisados enzimticos obtidos de subprodutos da corvina micropogonias furnieri.pdf: 1099496 bytes, checksum: f4121ee0cb5558274a8aa510dfe92eaf (MD5)<br>Rejected by Gilmar Barros (gilmargomesdebarros@gmail.com), reason: - Corrigir a citação: o artigo tem 80 f., e não 82 f. (sempre olhar o número de folhas pela ficha catalográfica, só quando não houver ficha catalográfica é que se deve olhar o que informa o Ado
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44

chaudhary, Arpana S. "Inhibitors of SecA as Potential Antimicrobial Agents." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/chemistry_diss/77.

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Protein translocation is essential for bacterial survival and the most important translocation mechanism in bacteria is the secretion (Sec) pathway. Thus targeting Sec pathway is a promising strategy for developing novel antibacterial therapeutics. We report the design, syntheses, mechanistic studies and structure-activity relationship studies using HQSAR and 3-D QSAR Topomer CoMFA analyses of 4-oxo-5-cyano thiouracil derivatives. In summary, introduction of polar group such as –N3 and linker groups such as –CH2-O- enhanced the potency as well as logP and logS several fold. We also report the
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45

Heilborn, Johan. "The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-432-5/.

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46

Lad, Mitaben D. "An investigation of protein and antimicrobial peptide interactions with model lipid membranes." Thesis, University of Reading, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443364.

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47

Chen, Kexun. "ANTIMICROBIAL RESPONSE OF AND BLOOD PLASMA PROTEIN ADSORPTION ON SILVER-DOPED HYDROXYAPATITE." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1523269330734553.

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48

Moreno, Marro Olga. "Starch-protein active films for food preservation." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/80616.

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The overall objective of the doctoral thesis was the development of starch-based (S) biodegradable active films for food packaging applications, by applying both casting method and thermoprocessing. Different blends of S with protein material have been studied in order to improve the functional properties of the films or confer antimicrobial/antioxidant activity. The following protein materials were used: powder buttermilk (BM); lactoferrin (LF) and/or lysozyme (LZ), and bovine gelatin (BG). Ethyl lauroyl arginate (LAE, E243) was also incorporated as antimicrobial compound. Likewise, S:BG blen
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49

Hu, Yaogang. "Design and Synthesis of Bioactive Peptidomimetics." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5504.

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Protein-Protein Interactions (PPIs) play a very important role in biological functions and therefore the inhibition of specific Protein-Protein Interactions has a huge therapeutic value. The most successful small molecular PPIs inhibitors do not fit with the prevalent `Rule of Five' drug profile. To overcome the disadvantages of small molecular PPIs inhibitors, peptide based PPIs inhibitors were developed. Herein we describe the development of a new class of peptidomimetics AA-peptides. The AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides tha
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50

Santos, Fellipe Bronze dos. "Análise bioquímica e estrutural das proteínas dermicidina-1L e sua splice variante em sistema biomimético." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-26062014-170711/.

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Dermicidina (DCD) é um gene mapeado no cromossomo 12, lócus 12q13.1, e codifica uma proteína de 110 aminoácidos, que sofre um processamento proteolítico, gerando peptídeos ativos. O peptídeo C-terminal (DCD-1L) de 48 aminoácidos tem uma carga -2, e exerce função antibacteriana e antifúngica, e o peptídeo C-terminal splice variante, denominado DCD-SV de 59 aminoácidos, tem carga neutra, e suas propriedades ainda não foram estabelecidas. Neste trabalho são apresentados os resultados da expressão, purificação e sequenciamento da DCD nativa produzida em E. coli BL21 transformada com o vetor pAE-DC
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