Relevant bibliographies by topics / Antimitotic Activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Antimitotic Activity'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Antimitotic Activity"

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Sundaresan, K., M. Thangavel, and K. Tharini. "Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 233–36. http://dx.doi.org/10.22270/jddt.v9i1.2228.

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The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine.
 Keywords: N-Benzyl piperidin 4-one oxime, me
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R. A. Ahirrao, B. S. Patange, and S. V. More. "Evaluation of Antimitotic Activity of Momordica Dioica Fruits on Allium Cepa Root Meristamatic Cells." Journal of Pharmaceutical Technology, Research and Management 7, no. 2 (2019): 67–71. http://dx.doi.org/10.15415/jptrm.2019.72009.

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Objective: Natural occurring phenolic compounds play an important role in cancer prevention and shows antimitotic activity. Number of active constituents like phenolic acid, curcuminoids, coumarine, ligans, quinones, etc. is showing antimitotic activity of Momordica dioica. The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells.Methods: The fruits are air dried and extracted with solvents like water by maceration method. The evaluation of antimitotic a
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Groult, Hugo, Isabel García-Álvarez, Lorenzo Romero-Ramírez, et al. "Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides." Nanomaterials 8, no. 8 (2018): 567. http://dx.doi.org/10.3390/nano8080567.

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The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive
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Badria, Farid A., Waell E. Houssein, Mona G. Zaghloul, and Ahmed F. Halim. "Antimitotic Activity of Gossypol and Gossypolone." Pharmaceutical Biology 39, no. 2 (2001): 120–26. http://dx.doi.org/10.1076/phbi.39.2.120.6257.

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Zhai, Lei, Anushree Balachandran, Rebecca Larkin, et al. "Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma." International Journal of Molecular Sciences 24, no. 21 (2023): 15571. http://dx.doi.org/10.3390/ijms242115571.

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MYCN amplification occurs in approximately 20–30% of neuroblastoma patients and correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the oncogenic function of MYCN. In this study, we identified mitotic dysregulation as a hallmark of tumor initiation in the pre-cancerous ganglia from TH-MYCN mice that persists through tumor progression. Single-cell quantitative-PCR of coeliac ganglia from 10-day-old TH-MYCN mice revealed overexpression of mitotic genes in a subpopulation of premalignant neurob
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Mohan, Gottumukkala Krishna, Malavika Yadav, M. Sandhya Rani, and Kalakotla Shanker. "Antimitotic activity of Borassus flabellifer Seed Coat." Research Journal of Pharmacognosy and Phytochemistry 8, no. 4 (2016): 223. http://dx.doi.org/10.5958/0975-4385.2016.00033.9.

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Satish, Ponnada* Bhagyalaxmi Suvvari. "Synthesis And Antimitotic Activity of Benzotriazole Compound." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2932–37. https://doi.org/10.5281/zenodo.15273474.

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The present work to Synthesize benzotriazole Nucleus and study the biological activity of Antimitotic method through by seed germination assay by using the green gram seeds. It is preliminary screening method to identify this benzotriazole basic nucleus is having Anticancer property. By using this seed germination assay method be can studied that this nucleus is having inhibition of seed germination Activity.
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Ramos, Sergio, Alba Vicente-Blázquez, Marta López-Rubio, Laura Gallego-Yerga, Raquel Álvarez, and Rafael Peláez. "Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition." International Journal of Molecular Sciences 24, no. 24 (2023): 17474. http://dx.doi.org/10.3390/ijms242417474.

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Antimitotic agents are one of the more successful types of anticancer drugs, but they suffer from toxicity and resistance. The application of approved drugs to new indications (i.e., drug repurposing) is a promising strategy for the development of new drugs. It relies on finding pattern similarities: drug effects to other drugs or conditions, similar toxicities, or structural similarity. Here, we recursively searched a database of approved drugs for structural similarity to several antimitotic agents binding to a specific site of tubulin, with the expectation of finding structures that could f
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Podila, Naresh, Mithun Rudrapal, Subramanyam Sibbala, et al. "In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues." Pharmacia 70, no. (4) (2023): 887–94. https://doi.org/10.3897/pharmacia.70.e109898.

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In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo-benzothiazole analogues in inhibiting the proliferation of cancer cells ei
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Reethu Metilda Manukonda and Satapathy Dhabal. "Phytochemical Analysis and Evaluation of In Vitro Antimitotic Activity of Allamanda cathartica Methanolic Extract." Journal of Pharma Insights and Research 2, no. 4 (2024): 146–54. http://dx.doi.org/10.69613/92x5vg75.

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Allamanda cathartica, a perennial shrub of the Apocynaceae family, has garnered significant attention in pharmacological research due to its diverse bioactive compounds and potential therapeutic applications. This study aimed to investigate the phytochemical composition and evaluate the in vitro antimitotic activity of A. cathartica methanolic extract. Comprehensive phytochemical screening revealed the presence of carbohydrates, alkaloids, saponin glycosides, proteins, tannins, flavonoids, and amino acids in the extract. The antimitotic potential was assessed using a seed germination assay wit
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Dissertations / Theses on the topic "Antimitotic Activity"

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Bortolozzi, Roberta. "Study of the mechanism of action of new molecules endowed with antitumoral activity." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422142.

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The microtubule system of eukaryotic cells is a critical element in a variety of fundamental cellular processes such as cell proliferation, mitotic spindle formation, maintenance of cell shape, regulation of motility, cell signaling, secretion, and intracellular transport. The important role of microtubules dynamic in mitosis progression and thus in cell proliferation, made them an attractive target for cancer therapy. Many chemically diverse compounds bind and affect tubulin-microtubule system, altering polymerization and dynamics during the particularly vulnerable mitotic stage of the cell c
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Radhakrishna, P. M. "Studies in the synthesis and antimitotic activity of Aza and other analogues of Beta-Apopicropodophyllin." Thesis, 1990. http://hdl.handle.net/2009/2551.

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Teesdale-Spittle, P. H., Klaus Pors, R. Brown, Laurence H. Patterson, and J. A. Plumb. "Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells." 2005. http://hdl.handle.net/10454/3191.

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No<br>A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant ce
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Book chapters on the topic "Antimitotic Activity"

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Commerçon, A., J. D. Bourzat, E. Didier, and François Lavelle. "Practical Semisynthesis and Antimitotic Activity of Docetaxel and Side-Chain Analogues." In ACS Symposium Series. American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1995-0583.ch017.

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Shih, Chuan, Rima S. Al-Awar, Andrew H. Fray, et al. "Synthesis and Structure-Activity Relationship Studies of Cryptophycins: A Novel Class of Potent Antimitotic Antitumor Depsipeptides." In Anticancer Agents. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch010.

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Madhuri, M. Lakshmi, N. V. L. Suvarchala Reddy V, M. Mamatha, and Syed Sara Afreen. "ANTIPROLIFERATIVE ACTIVITY AND MOLECULAR DOCKING STUDIES OF PHYTOCONSTITUENTS FROM SYZYGIUM ALTERNIFOLIUM BARK." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 15. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn15p6ch2.

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The present study carried out to investigate the in vitro antimitotic activity using Allium cepa root tip assay to examine the anticancer potential of Syzygium alternifolium. The phytoconstituents previously determined were subjected to molecular docking studies against Bcl-2 and VEGFR-2 protein as a target receptor to support anticancer activities. Methanolic extract of Syzygium alternifoliumshowed significant antimitotic activity by decreasing rate of mitosis in comparison to water. Methotrexate (0.1 mg/mL) was used as a standard andshows the highest antimitotic activity. Thus, the selected
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Haider, Kashif, and Mohammad Shahar Yar. "Advances of Benzimidazole Derivatives as Anticancer Agents: Bench to Bedside." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101702.

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Benzimidazole is one of the privileged nitrogen-containing scaffolds known for its versatile diversified role in insecticides, pesticides, dyes, pigments and pharmaceuticals. Due to its electron-rich environment, structural features and binding potency of various therapeutic targets, benzimidazole derivatives exhibit a broad spectrum of biological activity that majorly includes antimicrobial, antifungal, analgesics, anti-diabetic and anticancer agents. Several benzimidazole scaffolds bearing drugs are clinically approved; they are used for various indications. For example, Bilastine, Lerisetro
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Podila, Naresh, Sanapala Arun Kumar, Vijaya Kishore K., et al. "In-silico and In-vitro Antimitotic Activity of Some Novel 6-Fluoro-1, 2, 4-Triazolo-Benzothiazole Analogues." In Advanced Concepts in Pharmaceutical Research Vol. 5. B P International, 2024. http://dx.doi.org/10.9734/bpi/acpr/v5/7097e.

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Taber, Douglass F. "Alkaloid Synthesis: (−)-α-Kainic Acid (Ohshima), Serpentine (Scheidt), (−)-Galanthamine ( Jia), (+)-Trigolutes B (Gong), Sarain A (Yokoshima/Fukuyama), DZ-2384 (Harran)." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0060.

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(−)-α-Kainic acid 3 is widely used in neuropharmacological studies. En route to 3, Takashi Ohshima of Kyushu University found (Chem. Eur. J. 2015, 21, 3937) that the intramolecular ene cyclization of 1 delivered 2 with high diastereocontrol. Karl A. Scheidt of Northwestern University set (Angew. Chem. Int. Ed. 2015, 54, 6900) the absolute configuration of 5 and so of serpentine 6 by the organocatalyzed cyclization of 4. This is the first total synthesis of that alkaloid. Yanxing Jia of Peking University prepared (Angew. Chem. Int. Ed. 2015, 54, 6255) the benzofuran 8 by the Pd-mediated cycliza
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Conference papers on the topic "Antimitotic Activity"

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Burke, Patrick J., Joseph Z. Hamilton, Thomas A. Pires, Kim K. Emmerton, Peter D. Senter, and Scott C. Jeffrey. "Abstract A097: Tubulysin ADC payloads: An antimitotic drug class that retains activity in multidrug resistant models." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-a097.

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