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Journal articles on the topic 'Antimycobacterial susceptibility of antimicrobials'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Guay, David RP. "Nontuberculous Mycobacterial Infections." Annals of Pharmacotherapy 30, no. 7-8 (1996): 819–30. http://dx.doi.org/10.1177/106002809603000721.

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OBJECTIVE: To review the epidemiology, clinical manifestations, diagnosis, and treatment of nontuberculous mycobacterial infections other than Mycobacterium avium complex (MAC). DATA SOURCES: A MEDLINE search of English-language literature pertaining to nontuberculous mycobacteria other than MAC was performed. Additional literature was obtained from reference lists of pertinent articles identified through the search. STUDY SELECTION AND DATA EXTRACTION: All articles were considered for possible inclusion in the review. Information judged by the author to be pertinent was selected for discussio

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Solnier, Julia, Liam Martin, Sanjib Bhakta, and Franz Bucar. "Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species." Molecules 25, no. 3 (2020): 734. http://dx.doi.org/10.3390/molecules25030734.

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Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM) infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are limited due to the spread of antimicrobial resistance mechanism. Plant-derived natural compounds as prospective efflux pump inhibitors may present a promising adjunct to conventional chemotherapy by enhancing mycobacterial susceptibility to antibiotics. This study served to evaluate the antimicrobial and resistance-modifying profile of a range of plant-derived flavonoids against the mycobacterial model strains: M. smegma

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Borek, Anna, Anna Zabost, Agnieszka Głogowska, Dorota Filipczak, and Ewa Augustynowicz-Kopeć. "New RAPMYCOI SensititreTM Antimicrobial Susceptibility Test for Atypical Rapidly Growing Mycobacteria (RGM)." Diagnostics 12, no. 8 (2022): 1976. http://dx.doi.org/10.3390/diagnostics12081976.

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Rapidly growing mycobacteria (RGM) cause an increasing international concern, mainly due to their natural resistance to many antibiotics. The aim of this study was to conduct species identification and determine the antimicrobial susceptibility profiles of RGM isolated in Poland. Antimicrobial susceptibility was tested using broth microdilution and the RAPMYCOI panel. A total of 60 strains were analysed, including the following species: M. fortuitum complex (30), M. abscessus subsp. abscessus (16), M. abscessus subsp. massiliense (7), M. chelonae (5), and M. mucogenicum (2). For 12 M. abscessu

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Maisetta, Giuseppantonio, Giovanna Batoni, Manuela Pardini та ін. "Use of a Recombinant Strain of Mycobacterium avium Expressing β-Galactosidase To Evaluate the Activities of Antimycobacterial Agents inside Macrophages". Antimicrobial Agents and Chemotherapy 45, № 1 (2001): 356–58. http://dx.doi.org/10.1128/aac.45.1.356-358.2001.

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ABSTRACT A reliable and low-cost method that enables rapid screening of the activity exerted by new antimicrobial agents on intracellularly growingMycobacterium avium has been developed. To this aim, a recombinant (lacZ) strain of M. aviumexpressing the Escherichia coli β-galactosidase gene was used to evaluate, in murine macrophages, the susceptibility of M. avium to common antimycobacterial agents. β-Galactosidase levels, measured in the presence of each of the antibiotics tested, were closely correlated with the number of CFU recovered from theM. avium lacZ strain-infected macrophages.

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P, Melkeri Shridhar, P. Parameshwara Naik, Krishnamurthy G., Prabhaker Walmik, and Priyarani RS. "Synthesis, Characterization and Biological studies on 3d-metal complexes of 5-[(1, 5- dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4- methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile." Der Pharma Chemica 13, no. 3 (2021): 12. https://doi.org/10.5281/zenodo.11071253.

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N-hetorocyclic ligand 5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4-methyl-2-oxo1,2Dihydropyridine-3-carbonitrile (L) and a few of their transition metal complexes have been synthesised and characterized by different physicochemical techniques. The electronic and magnetic susceptibility measurements suggest an octahedral geometry for all the complexes excepting Zn(II) complex which possess tetrahedral geometry. The results of thermo-gravimetric analysis showed that the synthesized complexes have thermal stability and confirms the absence of coordina

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Srinivas, A. "Anti-microbial susceptibility pattern of spores used in Bacillus clausii suspension: an in vitro study." International Journal of Contemporary Pediatrics 7, no. 5 (2020): 980. http://dx.doi.org/10.18203/2349-3291.ijcp20201511.

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Background: Bacillus species have been used as probiotics as they have high stability to gastrointestinal conditions and impart health benefit on the host. Primarily used in their spore form the diversity of Bacillus species being used and their applications are remarkable. Here, we present the results of the antimicrobial susceptibility testing of the B. clausii spore suspension (Benegut®).Methods: Bacillus clausii spore suspension (Benegut®), used in oral bacteriotherapy was tested for the susceptibility to therapeutically useful antibiotics. Twelve commercially prepared, paper antibiotic di

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Arain, T. M., A. E. Resconi, M. J. Hickey, and C. K. Stover. "Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1536–41. http://dx.doi.org/10.1128/aac.40.6.1536.

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Bioluminescence-based assays to indicate antimicrobial susceptibility have been developed and validated for recombinant strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, and Mycobacterium intracellulare expressing an integrated eukaryotic luciferase gene. MICs determined with these bioluminescence assays for several antimycobacterial agents, including isoniazid, ethambutol, rifampin, amikacin, streptomycin, ciprofloxacin, and clarithromycin, compared favorably with traditional BACTEC methods and visual estimations of the inhibitory end point. Assay methodolog

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Alcaide, Fernando, Laura Calatayud, Miguel Santín, and Rogelio Martín. "Comparative In Vitro Activities of Linezolid, Telithromycin, Clarithromycin, Levofloxacin, Moxifloxacin, and Four Conventional Antimycobacterial Drugs against Mycobacterium kansasii." Antimicrobial Agents and Chemotherapy 48, no. 12 (2004): 4562–65. http://dx.doi.org/10.1128/aac.48.12.4562-4565.2004.

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ABSTRACT Mycobacterium kansasii is one of the most pathogenic and frequent nontuberculous mycobacteria isolated from humans. Patients with adverse drug reactions, resistant isolates, or suboptimal response require alternative treatment regimens. One hundred forty-eight consecutive clinical isolates of M. kansasii were tested for antimicrobial susceptibilities by the BACTEC 460 system (NCCLS) with two different inoculation protocols, one conventional and one alternative. In the alternative protocol, the inoculum 12B vial was incubated until the growth index was between 250 and 500. Four convent

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Schwander, Stephan, Srijata Sarkar, Youngmia Song та ін. "Suppression of the NF-κB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity (117.4)". Journal of Immunology 188, № 1_Supplement (2012): 117.4. http://dx.doi.org/10.4049/jimmunol.188.supp.117.4.

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Abstract Chronic exposure to air pollution increases susceptibility to respiratory infections including tuberculosis in humans. We hypothesized that exposure to diesel exhaust particles (DEP), a major component of urban fine particulate matter, suppresses antimycobacterial human immune effector cell functions by modulating TLR-signaling pathways and NF-κB activation. To examine the effects of DEP on M.tb-induced host immunity, PBMC from 20 healthy persons [13 m, 7 f, mean age 33.5 years) were stimulated with DEP and M.tb or PPD (purified protein derivative). We show by TEM studies that both DE

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Torres-Juarez, Flor, Albertina Cardenas-Vargas, Alejandra Montoya-Rosales, et al. "LL-37 Immunomodulatory Activity during Mycobacterium tuberculosis Infection in Macrophages." Infection and Immunity 83, no. 12 (2015): 4495–503. http://dx.doi.org/10.1128/iai.00936-15.

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Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility to this disease depends to a great extent on the innate immune response against mycobacteria. Host defense peptides (HDP) are one of the first barriers to counteract infection. Cathelicidin (LL-37) is an HDP that has many immunomodulatory effects besides its weak antimicrobial activity. Despite advances in the study of the innate immune response in tuberculosis, the immunological role of LL-37 duringM. tuberculosisinfection has not been clarified. Monocyte-derived macrophages were infected withM. tuberc

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Schwander, Stephan, Pasquale Cantarella, Srijata Sarkar, Megan Rockafellow, and César Rivas-Santiago. "Respiratory epithelial cell innate immunity against Mycobacterium tuberculosis is deregulated by air pollution particulate matter (PM) (INC7P.417)." Journal of Immunology 192, no. 1_Supplement (2014): 186.18. http://dx.doi.org/10.4049/jimmunol.192.supp.186.18.

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Abstract Epidemiological studies demonstrate a link between exposure to indoor air pollution and cigarette smoke and risk of development of Tuberculosis (TB). The role of ambient air pollution PM in human antimycobacterial immunity has not been studied. We examined the effects of PM (&lt;2.5 and &lt;10 μm diameter, from Mexico City) on Mycobacterium tuberculosis (M.tb)-induced expression of mRNA and protein of human β-defensin 2 and 3 (HBD-2,3, antimicrobial peptides), IL-8 and MCP-1 by qRT-PCR and ELISA, respectively. In addition, cell-mediated growth control of M.tb was measured by c

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Intorasoot, Sorasak, Amornrat Intorasoot, Arocha Tawteamwong, et al. "In Vitro Antimycobacterial Activity of Human Lactoferrin-Derived Peptide, D-hLF 1-11, against Susceptible and Drug-Resistant Mycobacterium tuberculosis and Its Synergistic Effect with Rifampicin." Antibiotics 11, no. 12 (2022): 1785. http://dx.doi.org/10.3390/antibiotics11121785.

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Tuberculosis is a highly contagious disease caused by the Mycobacterium tuberculosis complex (MTBC). Although TB is treatable, multidrug-resistant, extensively drug-resistant, and totally drug-resistant forms of M. tuberculosis have become a new life-threatening concern. New anti-TB drugs that are capable of curing these drug-resistant strains are urgently needed. The purpose of this study is to determine the antimycobacterial activity of D-enantiomer human lactoferricin 1-11 (D-hLF 1-11) against mycobacteria in vitro using a 3-(4,5-dimethylthiazol-2-yl)-2,5-dephenyltetrazolium bromide colorim

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13

Gilbert, P., J. Das, and I. Foley. "Biofilm Susceptibility to Antimicrobials." Advances in Dental Research 11, no. 1 (1997): 160–67. http://dx.doi.org/10.1177/08959374970110010701.

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Microbial biofilms, where organisms are intimately associated with each other and a solid substratum through binding and inclusion within an exopolymer matrix, are widely distributed in nature and disease. In the mouth, multispecies biofilms are associated not only with dental plaque and tooth decay but also with soft tissues of the buccal cavity and with most forms of periodontal disease. Organization of micro-organisms within biofilms confers, on the component species, properties which are not evident with the individual species grown independently or as planktonic populations in liquid medi

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Griffith, M. E., and H. L. Bodily. "Stability of antimycobacterial drugs in susceptibility testing." Antimicrobial Agents and Chemotherapy 36, no. 11 (1992): 2398–402. http://dx.doi.org/10.1128/aac.36.11.2398.

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Sánchez, Juan Gabriel Bueno, and Vladimir V. Kouznetsov. "Antimycobacterial susceptibility testing methods for natural products research." Brazilian Journal of Microbiology 41, no. 2 (2010): 270–77. http://dx.doi.org/10.1590/s1517-83822010000200001.

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16

Inderlied, C. B. "Antimycobacterial susceptibility testing: Present practices and future trends." European Journal of Clinical Microbiology & Infectious Diseases 13, no. 11 (1994): 980–93. http://dx.doi.org/10.1007/bf02111499.

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Qekwana, Daniel Nenene, Agricola Odoi, and James Wabwire Oguttu. "Efficacy Profiles of Antimicrobials Evaluated against Staphylococcus Species Isolated from Canine Clinical Specimens." Animals 11, no. 11 (2021): 3232. http://dx.doi.org/10.3390/ani11113232.

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Cross-resistance occurs between antimicrobials with either similar mechanisms of action and/or similar chemical structures, or even between unrelated antimicrobials. This study employed a multivariate approach to investigate the associations between the efficacy profile of antimicrobials and the clustering of eleven different antimicrobial agents based on their efficacy profile. Records of the susceptibility of 382 confirmed Staphylococcus species isolates against 15 antimicrobials based on the disc diffusion method were included in this study. Tetrachoric correlation coefficients were compute

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Pitaloka, Dian Ayu Eka, and Elin Yulinah Sukandar. "IN VITRO STUDY OF URSOLIC ACID COMBINATION FIRST-LINE ANTITUBERCULOSIS DRUGS AGAINST DRUG-SENSITIVE AND DRUG-RESISTANT STRAINS OF Mycobacterium tuberculosis." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 216. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16582.

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Objective: The resurgence of tuberculosis (TB) caused by Mycobacterium TB (MTB) is associated with the rapid spread of multidrug-resistant,therefore, the development of new antimycobacterial agents is necessary. The aim of this study was to evaluate the antimycobacterial activity ofursolic acid (UA) when it using alone and combination with TB drugs.Methods: MTB H37Rv strain, streptomycin-rifampicin resistant strain, and isoniazid-ethambutol resistant strain were evaluated by susceptibility testusing a serial number of UA (25-150 µg/mL). Minimum inhibitory concentration (MIC) was read as minimu

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Leps, Anna Sophia, Babette Klein, Marianne Schneider, and Sandra Goericke-Pesch. "How Restrictive Legislation Influences Antimicrobial Susceptibility in Selected Bacterial Isolates from the Canine Vagina." Antibiotics 13, no. 10 (2024): 946. http://dx.doi.org/10.3390/antibiotics13100946.

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Antimicrobial stewardship is one of the cornerstones in the battle against antimicrobial resistance. Restrictive legislation aims to foster antimicrobial stewardship. Prophylactic prescription of antimicrobials is still a widespread practice in canine breeding management to prevent suspected infectious infertility. The aim of this study was to evaluate the efficacy of restrictive legislation in Germany (Veterinary Home Pharmacy Ordinance, TÄHAV) based on resistance profiles of common bacterial isolates from the vaginal tract by comparing the resistance situation before (time frame (TF1)) and a

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Portaels, F., H. Traore, K. De Ridder, and W. M. Meyers. "In Vitro Susceptibility of Mycobacterium ulcerans to Clarithromycin." Antimicrobial Agents and Chemotherapy 42, no. 8 (1998): 2070–73. http://dx.doi.org/10.1128/aac.42.8.2070.

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ABSTRACT Buruli ulcer (BU), caused by Mycobacterium ulcerans, was recently recognized by the World Health Organization as an important emerging disease. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, medical management of BU lesions in patients presenting for treatment is usually disappointing, leaving wide surgical excision the only alternative. Advanced ulcerated lesions of BU rarely respond to antimycobacterial agents; however, perioperative administration of such drugs may prevent relapses or disseminated infections. Clarithromycin posses

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Brook, I., H. M. Wexler, and E. J. C. Goldstein. "Antianaerobic Antimicrobials: Spectrum and Susceptibility Testing." Clinical Microbiology Reviews 26, no. 3 (2013): 526–46. http://dx.doi.org/10.1128/cmr.00086-12.

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Chiaraviglio, Lucius, and James E. Kirby. "High-Throughput Intracellular Antimicrobial Susceptibility Testing of Legionella pneumophila." Antimicrobial Agents and Chemotherapy 59, no. 12 (2015): 7517–29. http://dx.doi.org/10.1128/aac.01248-15.

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ABSTRACTLegionella pneumophilais a Gram-negative opportunistic human pathogen that causes a severe pneumonia known as Legionnaires' disease. Notably, in the human host, the organism is believed to replicate solely within an intracellular compartment, predominantly within pulmonary macrophages. Consequently, successful therapy is predicated on antimicrobials penetrating into this intracellular growth niche. However, standard antimicrobial susceptibility testing methods test solely for extracellular growth inhibition. Here, we make use of a high-throughput assay to characterize intracellular gro

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Apley, Mike. "Antimicrobials and BRD." Animal Health Research Reviews 10, no. 2 (2009): 159–61. http://dx.doi.org/10.1017/s1466252309990223.

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AbstractPharmacodynamics is limited with respect to its ability to provide precise predictions to guide therapy because of complications related to the bound versus unbound state of the agent, tissue versus plasma concentrations, drug degradation over time, variations among microorganisms, and factors associated with the specific environment at the infection site. Antimicrobial susceptibility testing is likewise imprecise when applied to an individual animal; however, it is valuable on an animal population basis.

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COOK, ANGELA, RICHARD J. REID-SMITH, REBECCA J. IRWIN, SCOTT A. McEWEN, VIRGINIA YOUNG, and CARL RIBBLE. "Antimicrobial Resistance in Campylobacter, Salmonella, and Escherichia coli Isolated from Retail Grain-Fed Veal Meat from Southern Ontario, Canada." Journal of Food Protection 74, no. 8 (2011): 1245–51. http://dx.doi.org/10.4315/0362-028x.jfp-10-483.

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This study estimated the prevalence of Salmonella, Campylobacter, and Escherichia coli isolates in fresh retail grain-fed veal obtained in Ontario, Canada. The prevalence and antimicrobial resistance patterns were examined for points of public health significance. Veal samples (n = 528) were collected from February 2003 through May 2004. Twenty-one Salmonella isolates were recovered from 18 (4%) of 438 samples and underwent antimicrobial susceptibility testing. Resistance to one or more antimicrobials was found in 6 (29%) of 21 Salmonella isolates; 5 (24%) of 21 isolates were resistant to five

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Obregón-Henao, Andrés, Kimberly A. Arnett, Marcela Henao-Tamayo, et al. "Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6904–12. http://dx.doi.org/10.1128/aac.00459-15.

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ABSTRACTOver the last 10 years,Mycobacterium abscessusgroup strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. These opportunistic pathogens are widespread in the environment and can cause a wide range of clinical diseases, including skin, soft tissue, central nervous system, and disseminated infections; by far, the most difficult to treat is the pulmonary form. Infections withM. abscessusare often multidrug-resistant (MDR) and require prolonged treatment with various regimens and, many t

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Do, Thi Thuy, Jerónimo Rodríguez-Beltran, Esmeralda Cebrián-Sastre, Alexandro Rodríguez-Rojas, Alfredo Castañeda-García, and Jesús Blázquez. "Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in Mycobacterium smegmatis." Antibiotics 11, no. 4 (2022): 509. http://dx.doi.org/10.3390/antibiotics11040509.

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Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. Rifampicin resistance in mycobacteria is mainly caused by mutations in the rpoB gene; however, some rifampicin-resistant strains showed no rpoB mutations. Therefore, alternative mechanisms must explain this resistance in mycobacteria. In this work, a library of 11,000 Mycobacterium smegmatis mc2 155 insertion mutants was explored to search and characterize new rifampicin-resistance determinants. A transposon insertion in the MSMEG_194

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Moore, Andrea V., Scott M. Kirk, Steven M. Callister, Gerald H. Mazurek, and Ronald F. Schell. "Safe Determination of Susceptibility of Mycobacterium tuberculosis to Antimycobacterial Agents by Flow Cytometry." Journal of Clinical Microbiology 37, no. 3 (1999): 479–83. http://dx.doi.org/10.1128/jcm.37.3.479-483.1999.

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We showed previously that susceptibility testing forMycobacterium tuberculosis labeled with fluorescein diacetate could be accomplished rapidly by using flow cytometry. However, safety was a major concern because mycobacteria were not killed prior to flow cytometric analysis. In this study, we developed a biologically safe flow cytometric susceptibility test that depends on detection and enumeration of actively growing M. tuberculosis organisms in drug-free and antimycobacterial agent-containing medium. The susceptibilities of 17 clinical isolates of M. tuberculosis to ethambutol, isoniazid, a

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Druszczyńska, Magdalena, Magdalena Godkowicz, Jakub Kulesza, Sebastian Wawrocki, and Marek Fol. "Cytokine Receptors—Regulators of Antimycobacterial Immune Response." International Journal of Molecular Sciences 23, no. 3 (2022): 1112. http://dx.doi.org/10.3390/ijms23031112.

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Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid kil

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Saginur, Raphael, Melissa StDenis, Wendy Ferris, et al. "Multiple Combination Bactericidal Testing of Staphylococcal Biofilms from Implant-Associated Infections." Antimicrobial Agents and Chemotherapy 50, no. 1 (2006): 55–61. http://dx.doi.org/10.1128/aac.50.1.55-61.2006.

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ABSTRACT Standardized susceptibility testing fails to predict in vivo resistance of device-related infections to antimicrobials. We assessed agents and combinations of antimicrobials against clinical isolates of Staphylococcus epidermidis and S. aureus (methicillin-resistant S. aureus and methicillin-sensitive S. aureus) retrieved from device-associated infections. Isolates were grown planktonically and as biofilms. Biofilm cultures of the organisms were found to be much more resistant to inhibitory and bactericidal effects of single and combination antibiotics than planktonic cultures (P <

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K, Kalaiselvi, Mangayarkarasi V, Gomathi Ns, Balaji S, Shivshankar R. Mane, and Raja Shunmugam. "LUCIFERASE REPORTER MYCOBACTERIOPHAGES FOR EVALUATING NORBORNENE-BASED ANTITUBERCULOSIS DRUG SUSCEPTIBILITY TESTING ON MYCOBACTERIUM TUBERCULOSIS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 406. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19660.

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Objective: In 2015, 9.6 million people around the world became sick with tuberculosis (TB) disease and 1.5 million TB-related deaths worldwide. Recent increasing incidence of multidrug-resistant (MDR; resistance to at least rifampicin (RIF) and isoniazid [INH]) and extensively drug-resistant (MDR resistance plus resistance to a fluoroquinolone and an aminoglycoside) makes TB a serious concern. Lot of research is needed to deal with this infectious disease for a better alternative in treatment or modification of these older TB drugs. The present study aimed at evaluating antimycobacterial activ

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Hemanth, Kumar N. K., Rao K. Poornachandra, and Jagannath Shobha. "Evaluation of antibacterial potentialities of Terminalia arjuna wight & arn leaf gall: an ethnomedicinal plant." Biolife 2, no. 4 (2022): 1380–86. https://doi.org/10.5281/zenodo.7248607.

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<strong>ABSTRACT</strong> In the current exploration an attempt has been made to assess the antibacterial potentialities of <em>Terminalia arjuna</em> Wight and Arn leaf galls. It belongs to the family Combretaceae commonly known as ‘Arjuna’, an important ethno medicinal plant. The different solvent extract of <em>T. arjuna</em> leaf gall were subjected to antibacterial activity, total phenol and total carbohydrate content estimation. The antimicrobial susceptibility was screened by means of well diffusion, disc diffusion, MIC and MBC methods. The result showed that the methanol ex

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Singh, Ashok K., Shailendra K. Singh, Kavita Dhariyal, Ram Kumar, Amarendra Kumar, and Sudheer K. Singh. "Synthesis, Characterization and Antimycobacterial Activity of Phenanthrenequinone Thiosemicarbazones and their Ruthenium and Zinc Complexes." Asian Journal of Chemistry 33, no. 5 (2021): 983–88. http://dx.doi.org/10.14233/ajchem.2021.23127.

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The substituted phenanthrenequinone thiosemicarbazones (HL1, HL2 and HL3), and their metal complexes (M = Ru(II) or Zn(II); SM1, SM2, SM3 and SM4) were synthesized and characterized by FT-IR, 1H & 13C NMR and ESI-MS. The spectral data IR, 1H & 13C NMR and ESI-MS indicates two tridentate ligands coordinating in the form of an octahedral geometry. The gas phase geometry of all the zinc(II) and ruthenium(II) complexes was carried by using density functional theory (DFT). The antimycobacterial susceptibility testing at 100 μM of the complexes using resazurin microtiter plate assay resulted

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Lang, Markus, Uday S. Ganapathy, Rana Abdelaziz, Thomas Dick та Adrian Richter. "Broad-Spectrum In Vitro Activity of Nα-aroyl-N-aryl-Phenylalanine Amides against Non-Tuberculous Mycobacteria and Comparative Analysis of RNA Polymerases". Antibiotics 13, № 5 (2024): 404. http://dx.doi.org/10.3390/antibiotics13050404.

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This study investigates the in vitro activity of Nα-aroyl-N-aryl-phenylalanine amides (AAPs), previously identified as antimycobacterial RNA polymerase (RNAP) inhibitors, against a panel of 25 non-tuberculous mycobacteria (NTM). The compounds, including the hit compound MMV688845, were selected based on their structural diversity and previously described activity against mycobacteria. Bacterial strains, including the M. abscessus complex, M. avium complex, and other clinically relevant NTM, were cultured and subjected to growth inhibition assays. The results demonstrate significant activity ag

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Ekakoro, John E., G. Kenitra Hendrix, Lynn F. Guptill, and Audrey Ruple. "Antimicrobial susceptibility and risk factors for resistance among Escherichia coli isolated from canine specimens submitted to a diagnostic laboratory in Indiana, 2010–2019." PLOS ONE 17, no. 8 (2022): e0263949. http://dx.doi.org/10.1371/journal.pone.0263949.

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Escherichia coli (E. coli) is the most common Gram-negative pathogen isolated in human infections. Antimicrobial resistant (AMR) E. coli originating from dogs may directly or indirectly cause disease in humans. The objective of this study was to calculate the proportion of antimicrobial susceptible E. coli isolated from canine specimens submitted to the Indiana Animal Disease Diagnostic Laboratory and to identify temporal patterns of susceptibility among these isolates. Susceptibility data of 2,738 E. coli isolates from dogs from 2010 through 2019 were used in this study. Proportions of isolat

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Kuppusamy, Willcox, Black, and Kumar. "Short Cationic Peptidomimetic Antimicrobials." Antibiotics 8, no. 2 (2019): 44. http://dx.doi.org/10.3390/antibiotics8020044.

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The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials.

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Ozawa, Manao, Michiko Kawanishi, Mariko Uchiyama, et al. "Correlation of minimum inhibitory concentrations between human and animal antimicrobials against Escherichia coli isolated from livestock." Journal of Veterinary Diagnostic Investigation 33, no. 4 (2021): 744–48. http://dx.doi.org/10.1177/10406387211019718.

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We analyzed the correlation between minimum inhibitory concentrations (MICs) of antimicrobials used in humans and those used in animals to enable comparison of antimicrobial susceptibility between Escherichia coli isolated from humans and those from animals. We compared the following pairs of MIC data: piperacillin (PIPC) to ampicillin (ABPC), amikacin (AMK) to kanamycin (KM), minocycline (MINO) to oxytetracycline (OTC), and levofloxacin (LVFX) to enrofloxacin (ERFX) using 103 isolates of E. coli from healthy livestock (cattle, pigs, broiler chickens, and layer chickens). Kappa analysis of the

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Akalu, Aberaw, Tekalign Tadesse, Haile Alemayehu, Girmay Medhin, Desalegn Woldeyohannes, and Tadesse Eguale. "Prevalence and Antimicrobial Susceptibility Profile of Salmonella from Poultry Farms and In-Contact Humans and Associated Risk Factors in Addis Ababa, Ethiopia." International Journal of Microbiology 2024 (April 26, 2024): 1–12. http://dx.doi.org/10.1155/2024/4227460.

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Poultry and poultry products are the common sources of Salmonella,which is one of the serious food-borne bacterial diseases in humans. Little is known about the status of Salmonella and their antimicrobial susceptibility in poultry farms in Addis Ababa. This study was conducted to estimate the prevalence and antimicrobial susceptibility of Salmonella isolates and to investigate possible risk factors for the occurrence of Salmonella in poultry farms in Addis Ababa. We recruited 58 poultry farms, from which 471 poultry-related samples and 44 stool samples from in-contact humans were collected. T

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MAINALI, C., M. McFALL, R. KING, and R. IRWIN. "Evaluation of Antimicrobial Resistance Profiles of Salmonella Isolates from Broiler Chickens at Slaughter in Alberta, Canada." Journal of Food Protection 77, no. 3 (2014): 485–92. http://dx.doi.org/10.4315/0362-028x.jfp-13-363.

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Antimicrobial-resistant Salmonella species are threatening to become a serious public health problem. Therefore, surveillance and prudent use of antimicrobials is needed in both the agricultural and human health sectors. The aim of this study was to describe the antimicrobial susceptibility profiles of Salmonella isolates recovered from healthy broiler chickens at slaughter from November 2004 to April 2005. Salmonella isolates recovered from 36 broiler flocks in Alberta, Canada, were serotyped and tested for antimicrobial susceptibility against 15 antimicrobials. Of 272 Salmonella isolates tes

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Lagacé-Wiens, Philippe RS, Melanie R. DeCorby, Patricia J. Baudry, et al. "Differences in Antimicrobial Susceptibility inEscherichia colifrom Canadian Intensive Care Units Based on Regional and Demographic Variables." Canadian Journal of Infectious Diseases and Medical Microbiology 19, no. 4 (2008): 282–86. http://dx.doi.org/10.1155/2008/568458.

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OBJECTIVES:Escherichia coliresistance to antimicrobials varies according to many factors.E coliisolates from Canadian intensive care units (ICUs) were studied to determine the distribution and demographics associated with antimicrobial resistance in this population.METHODS: The Canadian National Intensive Care Unit (CAN-ICU) study characterized pathogens isolated in Canadian ICUs from July 2005 to June 2006.E colisusceptibility to 10 antimicrobials was determined and a multivariate logistic regression model was designed to determine whether region, sex, isolation from a sterile site and age (y

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Chew, Ka Lip, Sophie Octavia, Siang Fei Yeoh, and Jeanette W. P. Teo. "In Vitro Susceptibility of Nocardia farcinica to the Antimycobacterial Drug Clofazimine." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e01849-20. http://dx.doi.org/10.1128/aac.01849-20.

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Sabbour, M. S., L. M. Osman, T. Abd-El-Hamid, and W. F. El-Baz. "Present Day Susceptibility of Urinary Pathogens to Antimicrobials." Drugs 34, Supplement 1 (1987): 176–87. http://dx.doi.org/10.2165/00003495-198700341-00037.

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Owusu, Enid, Mercy J. Newman, Kwesi K. Addo, and Phyllis Addo. "In Vitro Susceptibility ofMycobacterium ulceransIsolates to Selected Antimicrobials." Canadian Journal of Infectious Diseases and Medical Microbiology 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/5180984.

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Background.The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one. This is as a result of drug misuse by health personnel and patients’ noncompliance to treatment regimen. Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease. This study therefore investigated the inhibitory activity of some antibiotics against isolates ofMycobacterium ulcerans.Methods.Activity of eight antibiotics was tested against twelveM. ulceransisolates (2 referen

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ZENILMAN, JONATHAN M. "Gonococcal Susceptibility to Antimicrobials in Baltimore, 1988–1994." Sexually Transmitted Diseases 23, no. 3 (1996): 213–18. http://dx.doi.org/10.1097/00007435-199605000-00009.

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COOK, ANGELA, RICHARD REID-SMITH, REBECCA IRWIN, SCOTT A. McEWEN, ALFONSO VALDIVIESO-GARCIA, and CARL RIBBLE. "Antimicrobial Resistance in Campylobacter, Salmonella, and Escherichia coli Isolated from Retail Turkey Meat from Southern Ontario, Canada." Journal of Food Protection 72, no. 3 (2009): 473–81. http://dx.doi.org/10.4315/0362-028x-72.3.473.

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This study estimated the prevalence of Campylobacter, Salmonella, and Escherichia coli isolated from fresh retail turkey purchased at grocery stores in Ontario, Canada. The antimicrobial susceptibility patterns were determined and assessed for potential public health risk. From February 2003 to May 2004, 465 raw turkey meat samples were collected. Antimicrobial susceptibility testing was performed for Campylobacter isolates with a concentration gradient test and for Salmonella and E. coli isolates with a broth microdilution assay. Campylobacter isolates were recovered from 188 (46%) of 412 sam

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Sękowska, Alicja, Yulian Konechnyi, and Andrés Carrazco-Montalvo. "Identification, Antimicrobial Susceptibility and Clinical Significance of Klebsiella variicola Strains." Microbiology Research 16, no. 6 (2025): 123. https://doi.org/10.3390/microbiolres16060123.

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Klebsiella variicola strains are Gram-negative rod-shaped bacteria that usually cause bloodstream, urinary and respiratory tract infections. The aim of the study was to identify K. variicola strains, evaluate the susceptibility of strains to selected antimicrobials, and detect their resistance mechanisms to β-lactams. Strain identification was performed using the mass spectrometry method. DNA sequencing was performed for selected strains. Susceptibility to selected antimicrobials was assessed using an automated method. The presence of an antimicrobial resistance mechanism and genes encoding ES

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Cardoso, Alexander Machado, Vinicius Ribeiro Flores, Gabriel Gomes do Rosario, et al. "Antimicrobial Susceptibility of Escherichia coli Isolates Causing Community-Acquired Urinary Tract Infections: Comparison of Methods." Microorganisms 13, no. 2 (2025): 231. https://doi.org/10.3390/microorganisms13020231.

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Due to bacterial resistance to antimicrobials, antibiotic therapy for urinary tract infections (UTIs) has become a major challenge for clinicians. The present work aimed to compare the antimicrobial susceptibility profiles of 53 uropathogenic Escherichia coli (UPEC) isolates, assessed using the disk diffusion method and two automated systems (PHOENIX BD™ and VITEK2), with interpretations based on CLSI and BrCAST guidelines. Twenty-five antibiotics were tested to assess differences in susceptibility profiles. Statistical tools, including Kappa coefficient analysis and chi-square tests, were app

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Berge, Anna Catharina B., Dale A. Moore, and William M. Sischo. "Field Trial Evaluating the Influence of Prophylactic and Therapeutic Antimicrobial Administration on Antimicrobial Resistance of Fecal Escherichia coli in Dairy Calves." Applied and Environmental Microbiology 72, no. 6 (2006): 3872–78. http://dx.doi.org/10.1128/aem.02239-05.

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ABSTRACT The objective of this study was to describe the influence of in-feed and therapeutic antimicrobials on resistance in commensal fecal Escherichia coli isolated from preweaned calves. Four groups of 30, day-old calf-ranch calves were enrolled and raised until 4 weeks of age. Groups 1 to 3 were raised without antimicrobials in the feed. Group 1 was isolated from the other groups and received no antimicrobial therapy. Group 2 was housed on the calf ranch and did not receive antimicrobial therapy, whereas groups 3 and 4 could be treated with antimicrobials. Group 4 was fed neomycin and tet

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Spierer, Oriel, Darlene Miller, and Terrence P. O’Brien. "Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates." British Journal of Ophthalmology 102, no. 5 (2018): 708–12. http://dx.doi.org/10.1136/bjophthalmol-2017-311751.

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Background/aimsAchromobacter xylosoxidans and Stenotrophomonas maltophilia are emerging corneal pathogens, which are closely related to Pseudomonas aeruginosa, and have intrinsic resistance to many commonly available antimicrobials. The purpose of this study is to compare the in vitro efficacy of 12 antimicrobial agents against A. xylosoxidans, S. maltophilia and P. aeruginosa isolates recovered from clinical cases of keratitis.MethodsRecovered corneal isolates (n=58) were identified and extracted from the Microbiology Data Bank of the Bascom Palmer Eye Institute. Comparative in vitro minimum

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Bizuwork, Ketema, Haile Alemayehu, Girmay Medhin, Wondwossen Amogne, and Tadesse Eguale. "Asymptomatic Bacteriuria among Pregnant Women in Addis Ababa, Ethiopia: Prevalence, Causal Agents, and Their Antimicrobial Susceptibility." International Journal of Microbiology 2021 (July 17, 2021): 1–8. http://dx.doi.org/10.1155/2021/8418043.

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Asymptomatic bacteriuria (ASBU) is an important health problem among pregnant women, particularly in low-income countries. This study aimed to estimate the prevalence of ASBU and potential risk factors among pregnant women attending antenatal care centers in Addis Ababa. It also aimed to identify causal bacterial pathogens and to assess their antimicrobial susceptibility. A health facility-based cross-sectional study was conducted from March to June 2019. Urine samples from a total of 281 pregnant women with no symptoms of urinary tract infection were tested for ASBU. Women whose urine samples

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Yang, Dong, Yanfang Zhang, Ibrahima Sory Sow, et al. "Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes." Microorganisms 11, no. 10 (2023): 2611. http://dx.doi.org/10.3390/microorganisms11102611.

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Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20–100 µM of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilm develop

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