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Journal articles on the topic 'Antimycobacterial susceptibility'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Griffith, M. E., and H. L. Bodily. "Stability of antimycobacterial drugs in susceptibility testing." Antimicrobial Agents and Chemotherapy 36, no. 11 (1992): 2398–402. http://dx.doi.org/10.1128/aac.36.11.2398.

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2

Pitaloka, Dian Ayu Eka, and Elin Yulinah Sukandar. "IN VITRO STUDY OF URSOLIC ACID COMBINATION FIRST-LINE ANTITUBERCULOSIS DRUGS AGAINST DRUG-SENSITIVE AND DRUG-RESISTANT STRAINS OF Mycobacterium tuberculosis." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 216. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16582.

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Objective: The resurgence of tuberculosis (TB) caused by Mycobacterium TB (MTB) is associated with the rapid spread of multidrug-resistant,therefore, the development of new antimycobacterial agents is necessary. The aim of this study was to evaluate the antimycobacterial activity ofursolic acid (UA) when it using alone and combination with TB drugs.Methods: MTB H37Rv strain, streptomycin-rifampicin resistant strain, and isoniazid-ethambutol resistant strain were evaluated by susceptibility testusing a serial number of UA (25-150 µg/mL). Minimum inhibitory concentration (MIC) was read as minimu

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3

Sánchez, Juan Gabriel Bueno, and Vladimir V. Kouznetsov. "Antimycobacterial susceptibility testing methods for natural products research." Brazilian Journal of Microbiology 41, no. 2 (2010): 270–77. http://dx.doi.org/10.1590/s1517-83822010000200001.

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4

Inderlied, C. B. "Antimycobacterial susceptibility testing: Present practices and future trends." European Journal of Clinical Microbiology & Infectious Diseases 13, no. 11 (1994): 980–93. http://dx.doi.org/10.1007/bf02111499.

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5

Portaels, F., H. Traore, K. De Ridder, and W. M. Meyers. "In Vitro Susceptibility of Mycobacterium ulcerans to Clarithromycin." Antimicrobial Agents and Chemotherapy 42, no. 8 (1998): 2070–73. http://dx.doi.org/10.1128/aac.42.8.2070.

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ABSTRACT Buruli ulcer (BU), caused by Mycobacterium ulcerans, was recently recognized by the World Health Organization as an important emerging disease. While antimycobacterial therapy is often effective for the earliest nodular or ulcerative lesions, medical management of BU lesions in patients presenting for treatment is usually disappointing, leaving wide surgical excision the only alternative. Advanced ulcerated lesions of BU rarely respond to antimycobacterial agents; however, perioperative administration of such drugs may prevent relapses or disseminated infections. Clarithromycin posses

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Do, Thi Thuy, Jerónimo Rodríguez-Beltran, Esmeralda Cebrián-Sastre, Alexandro Rodríguez-Rojas, Alfredo Castañeda-García, and Jesús Blázquez. "Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in Mycobacterium smegmatis." Antibiotics 11, no. 4 (2022): 509. http://dx.doi.org/10.3390/antibiotics11040509.

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Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. Rifampicin resistance in mycobacteria is mainly caused by mutations in the rpoB gene; however, some rifampicin-resistant strains showed no rpoB mutations. Therefore, alternative mechanisms must explain this resistance in mycobacteria. In this work, a library of 11,000 Mycobacterium smegmatis mc2 155 insertion mutants was explored to search and characterize new rifampicin-resistance determinants. A transposon insertion in the MSMEG_194

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K, Kalaiselvi, Mangayarkarasi V, Gomathi Ns, Balaji S, Shivshankar R. Mane, and Raja Shunmugam. "LUCIFERASE REPORTER MYCOBACTERIOPHAGES FOR EVALUATING NORBORNENE-BASED ANTITUBERCULOSIS DRUG SUSCEPTIBILITY TESTING ON MYCOBACTERIUM TUBERCULOSIS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 406. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19660.

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Objective: In 2015, 9.6 million people around the world became sick with tuberculosis (TB) disease and 1.5 million TB-related deaths worldwide. Recent increasing incidence of multidrug-resistant (MDR; resistance to at least rifampicin (RIF) and isoniazid [INH]) and extensively drug-resistant (MDR resistance plus resistance to a fluoroquinolone and an aminoglycoside) makes TB a serious concern. Lot of research is needed to deal with this infectious disease for a better alternative in treatment or modification of these older TB drugs. The present study aimed at evaluating antimycobacterial activ

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8

Singh, Ashok K., Shailendra K. Singh, Kavita Dhariyal, Ram Kumar, Amarendra Kumar, and Sudheer K. Singh. "Synthesis, Characterization and Antimycobacterial Activity of Phenanthrenequinone Thiosemicarbazones and their Ruthenium and Zinc Complexes." Asian Journal of Chemistry 33, no. 5 (2021): 983–88. http://dx.doi.org/10.14233/ajchem.2021.23127.

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The substituted phenanthrenequinone thiosemicarbazones (HL1, HL2 and HL3), and their metal complexes (M = Ru(II) or Zn(II); SM1, SM2, SM3 and SM4) were synthesized and characterized by FT-IR, 1H & 13C NMR and ESI-MS. The spectral data IR, 1H & 13C NMR and ESI-MS indicates two tridentate ligands coordinating in the form of an octahedral geometry. The gas phase geometry of all the zinc(II) and ruthenium(II) complexes was carried by using density functional theory (DFT). The antimycobacterial susceptibility testing at 100 μM of the complexes using resazurin microtiter plate assay resulted

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9

Obregón-Henao, Andrés, Kimberly A. Arnett, Marcela Henao-Tamayo, et al. "Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6904–12. http://dx.doi.org/10.1128/aac.00459-15.

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ABSTRACTOver the last 10 years,Mycobacterium abscessusgroup strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. These opportunistic pathogens are widespread in the environment and can cause a wide range of clinical diseases, including skin, soft tissue, central nervous system, and disseminated infections; by far, the most difficult to treat is the pulmonary form. Infections withM. abscessusare often multidrug-resistant (MDR) and require prolonged treatment with various regimens and, many t

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Lang, Markus, Uday S. Ganapathy, Rana Abdelaziz, Thomas Dick та Adrian Richter. "Broad-Spectrum In Vitro Activity of Nα-aroyl-N-aryl-Phenylalanine Amides against Non-Tuberculous Mycobacteria and Comparative Analysis of RNA Polymerases". Antibiotics 13, № 5 (2024): 404. http://dx.doi.org/10.3390/antibiotics13050404.

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This study investigates the in vitro activity of Nα-aroyl-N-aryl-phenylalanine amides (AAPs), previously identified as antimycobacterial RNA polymerase (RNAP) inhibitors, against a panel of 25 non-tuberculous mycobacteria (NTM). The compounds, including the hit compound MMV688845, were selected based on their structural diversity and previously described activity against mycobacteria. Bacterial strains, including the M. abscessus complex, M. avium complex, and other clinically relevant NTM, were cultured and subjected to growth inhibition assays. The results demonstrate significant activity ag

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11

Guay, David RP. "Nontuberculous Mycobacterial Infections." Annals of Pharmacotherapy 30, no. 7-8 (1996): 819–30. http://dx.doi.org/10.1177/106002809603000721.

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OBJECTIVE: To review the epidemiology, clinical manifestations, diagnosis, and treatment of nontuberculous mycobacterial infections other than Mycobacterium avium complex (MAC). DATA SOURCES: A MEDLINE search of English-language literature pertaining to nontuberculous mycobacteria other than MAC was performed. Additional literature was obtained from reference lists of pertinent articles identified through the search. STUDY SELECTION AND DATA EXTRACTION: All articles were considered for possible inclusion in the review. Information judged by the author to be pertinent was selected for discussio

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12

Moore, Andrea V., Scott M. Kirk, Steven M. Callister, Gerald H. Mazurek, and Ronald F. Schell. "Safe Determination of Susceptibility of Mycobacterium tuberculosis to Antimycobacterial Agents by Flow Cytometry." Journal of Clinical Microbiology 37, no. 3 (1999): 479–83. http://dx.doi.org/10.1128/jcm.37.3.479-483.1999.

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We showed previously that susceptibility testing forMycobacterium tuberculosis labeled with fluorescein diacetate could be accomplished rapidly by using flow cytometry. However, safety was a major concern because mycobacteria were not killed prior to flow cytometric analysis. In this study, we developed a biologically safe flow cytometric susceptibility test that depends on detection and enumeration of actively growing M. tuberculosis organisms in drug-free and antimycobacterial agent-containing medium. The susceptibilities of 17 clinical isolates of M. tuberculosis to ethambutol, isoniazid, a

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13

Druszczyńska, Magdalena, Magdalena Godkowicz, Jakub Kulesza, Sebastian Wawrocki, and Marek Fol. "Cytokine Receptors—Regulators of Antimycobacterial Immune Response." International Journal of Molecular Sciences 23, no. 3 (2022): 1112. http://dx.doi.org/10.3390/ijms23031112.

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Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid kil

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14

Yang, Dong, Yanfang Zhang, Ibrahima Sory Sow, et al. "Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes." Microorganisms 11, no. 10 (2023): 2611. http://dx.doi.org/10.3390/microorganisms11102611.

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Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20–100 µM of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilm develop

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15

Chew, Ka Lip, Sophie Octavia, Siang Fei Yeoh, and Jeanette W. P. Teo. "In Vitro Susceptibility of Nocardia farcinica to the Antimycobacterial Drug Clofazimine." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e01849-20. http://dx.doi.org/10.1128/aac.01849-20.

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16

Hannan, Abdul, Saira Munir, Muhammad Usman Arshad, and Nabila Bashir. "In Vitro Antimycobacterial Activity of Pakistani Beri Honey Using BACTEC MGIT 960." International Scholarly Research Notices 2014 (October 7, 2014): 1–4. http://dx.doi.org/10.1155/2014/490589.

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Background. Tuberculosis (TB) is a chronic bacterial disease. Mycobacterium tuberculosis, being the leading member of the MTB complex, is the main cause of tuberculosis worldwide. Tuberculosis is managed with combination of drugs: streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. Over the recent past years resistance against first line antituberculous drugs has emerged rapidly throughout the world resulting in MDR strains. The new threat in the management of MDR-TB is the development of resistance against second line drugs: aminoglycosides, polypeptides, fluoroquinolones, and

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17

Washington, J. A. "Functions and activities of the Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards." Clinical Microbiology Reviews 4, no. 2 (1991): 150–55. http://dx.doi.org/10.1128/cmr.4.2.150.

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The Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards has responsibility for the development of guidelines and standards in the field of clinical microbiology. Through the consensus process, representatives from government, industry, and professional societies have developed standards on antibacterial susceptibility testing (M2, M7, and M11), antimycobacterial susceptibility testing (M24), quality assurance on commercially prepared microbiological culture media (M22), evaluation of production lots of dehydrated Mueller-Hinton agar (M6), and preparation

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18

Tsukamura, Michio. "Differentiation ofMycobacterium gordonaefromMycobacterium scrofulaceumandMycobacterium szulgaiby Susceptibility to Enoxacin (Antimycobacterial Activity of Enoxacin)." Microbiology and Immunology 30, no. 9 (1986): 931–33. http://dx.doi.org/10.1111/j.1348-0421.1986.tb03022.x.

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19

Schoutrop, Esther L. M., Michelle A. E. Brouwer, Josien C. A. Jenniskens, et al. "The stability of antimycobacterial drugs in media used for drug susceptibility testing." Diagnostic Microbiology and Infectious Disease 92, no. 4 (2018): 305–8. http://dx.doi.org/10.1016/j.diagmicrobio.2018.06.015.

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20

Krajewska-Wędzina, Monika, Anna Zabost, Ewa Augustynowicz-Kopeć, Marcin Weiner, and Krzysztof Szulowski. "Evaluation of susceptibility to antimycobacterial drugs in Mycobacterium tuberculosis complex strains isolated from cattle in Poland." Journal of Veterinary Research 61, no. 1 (2017): 23–26. http://dx.doi.org/10.1515/jvetres-2017-0003.

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Abstract Introduction: Tuberculosis is a highly infectious disease affecting humans and animals. It is caused by the Mycobacterium tuberculosis complex (MTBC) – Mycobacterium bovis and Mycobacterium caprae, which are aetiological factors of bovine tuberculosis (bTB). In Poland, the bTB eradication programme exists. Animals diagnosed with tuberculosis are in the majority of cases not treated, but removed from their herd and then sanitary slaughtered. Material and Methods: In total, 134 MTBC strains isolated from cattle in Poland were subjected to microbiological analysis. The resistance phenoty

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Soetaert, Karine, Céline Rens, Xiao-Ming Wang, et al. "Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria." Antimicrobial Agents and Chemotherapy 59, no. 8 (2015): 5057–60. http://dx.doi.org/10.1128/aac.04856-14.

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ABSTRACTMycobacterium tuberculosisis wrapped in complex waxes, impermeable to most antibiotics. ComparingMycobacterium bovisBCG andM. tuberculosismutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycoba

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Maisetta, Giuseppantonio, Giovanna Batoni, Manuela Pardini та ін. "Use of a Recombinant Strain of Mycobacterium avium Expressing β-Galactosidase To Evaluate the Activities of Antimycobacterial Agents inside Macrophages". Antimicrobial Agents and Chemotherapy 45, № 1 (2001): 356–58. http://dx.doi.org/10.1128/aac.45.1.356-358.2001.

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ABSTRACT A reliable and low-cost method that enables rapid screening of the activity exerted by new antimicrobial agents on intracellularly growingMycobacterium avium has been developed. To this aim, a recombinant (lacZ) strain of M. aviumexpressing the Escherichia coli β-galactosidase gene was used to evaluate, in murine macrophages, the susceptibility of M. avium to common antimycobacterial agents. β-Galactosidase levels, measured in the presence of each of the antibiotics tested, were closely correlated with the number of CFU recovered from theM. avium lacZ strain-infected macrophages.

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Doležal, Martin, Jiří Hartl, Antonín Lyčka, Vladimír Buchta, and Želmíra Odlerová. "Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides." Collection of Czechoslovak Chemical Communications 61, no. 7 (1996): 1102–8. http://dx.doi.org/10.1135/cccc19961102.

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A series of N-substituted 3-amino-5-thiocarbamoyl-2-pyrazinecarboxamides was prepared. The structure of compounds was confirmed by elemental analysis, IR and 1H NMR spectra. The results of in vitro antifugal and antimycobacterial susceptibility testing shown no activity against pathogenic fungi and some effect on mycobacteria. The highest antituberculotic activity (MIC within 25-50 mg ml-1) against Mycobacterium tuberculosis and other mycobacterial strains in this series was shown by 3-(3-hydroxyphenylamino)-5-thiocarbamoyl-2-pyrazinecarboxamide. The antituberculotic activity of these compound

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Borek, Anna, Anna Zabost, Agnieszka Głogowska, Dorota Filipczak, and Ewa Augustynowicz-Kopeć. "New RAPMYCOI SensititreTM Antimicrobial Susceptibility Test for Atypical Rapidly Growing Mycobacteria (RGM)." Diagnostics 12, no. 8 (2022): 1976. http://dx.doi.org/10.3390/diagnostics12081976.

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Rapidly growing mycobacteria (RGM) cause an increasing international concern, mainly due to their natural resistance to many antibiotics. The aim of this study was to conduct species identification and determine the antimicrobial susceptibility profiles of RGM isolated in Poland. Antimicrobial susceptibility was tested using broth microdilution and the RAPMYCOI panel. A total of 60 strains were analysed, including the following species: M. fortuitum complex (30), M. abscessus subsp. abscessus (16), M. abscessus subsp. massiliense (7), M. chelonae (5), and M. mucogenicum (2). For 12 M. abscessu

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25

Sankar, Manimuthu, Krishnamoorthy Gopinath, Roopak Singla, and Sarman Singh. "In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay." Annals of Clinical Microbiology and Antimicrobials 7, no. 1 (2008): 15. http://dx.doi.org/10.1186/1476-0711-7-15.

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26

Kumar, Rupesh, Bhavani Shankar Madhumathi, and Valakunja Nagaraja. "Molecular Basis for the Differential Quinolone Susceptibility of Mycobacterial DNA Gyrase." Antimicrobial Agents and Chemotherapy 58, no. 4 (2014): 2013–20. http://dx.doi.org/10.1128/aac.01958-13.

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ABSTRACTDNA gyrase is a type II topoisomerase that catalyzes the introduction of negative supercoils in the genomes of eubacteria. Fluoroquinolones (FQs), successful as drugs clinically, target the enzyme to trap the gyrase-DNA complex, leading to the accumulation of double-strand breaks in the genome. Mycobacteria are less susceptible to commonly used FQs. However, an 8-methoxy-substituted FQ, moxifloxacin (MFX), is a potent antimycobacterial, and a higher susceptibility of mycobacterial gyrase to MFX has been demonstrated. Although several models explain the mechanism of FQ action and gyrase

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Arain, T. M., A. E. Resconi, M. J. Hickey, and C. K. Stover. "Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1536–41. http://dx.doi.org/10.1128/aac.40.6.1536.

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Bioluminescence-based assays to indicate antimicrobial susceptibility have been developed and validated for recombinant strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, and Mycobacterium intracellulare expressing an integrated eukaryotic luciferase gene. MICs determined with these bioluminescence assays for several antimycobacterial agents, including isoniazid, ethambutol, rifampin, amikacin, streptomycin, ciprofloxacin, and clarithromycin, compared favorably with traditional BACTEC methods and visual estimations of the inhibitory end point. Assay methodolog

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Tariq, Ezza Binte, Urooj Subhan, Farah Deeba, and Sidra Younis. "Tuberculosis and scavenger receptors: Exploring their relationship." Journal of Shifa Tameer-e-Millat University 6, no. 2 (2024): 113–21. http://dx.doi.org/10.32593/jstmu/vol6.iss2.268.

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Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries. Several risk factors are associated with TB infection and its progression from infection to disease onset, including host factors, microbial factors, environmental factors, and socio-economic status. Host genetic factors play a significant role in determining susceptibility to acquiring infection, progression to active disease, and the severity of the disease. Innate immunity is essential in the initial defense, advancement, and long-term control of mycobacterial infection. Among va

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P, Melkeri Shridhar, P. Parameshwara Naik, Krishnamurthy G., Prabhaker Walmik, and Priyarani RS. "Synthesis, Characterization and Biological studies on 3d-metal complexes of 5-[(1, 5- dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4- methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile." Der Pharma Chemica 13, no. 3 (2021): 12. https://doi.org/10.5281/zenodo.11071253.

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N-hetorocyclic ligand 5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) diazenyl]-1-ethyl-6-hydroxy-4-methyl-2-oxo1,2Dihydropyridine-3-carbonitrile (L) and a few of their transition metal complexes have been synthesised and characterized by different physicochemical techniques. The electronic and magnetic susceptibility measurements suggest an octahedral geometry for all the complexes excepting Zn(II) complex which possess tetrahedral geometry. The results of thermo-gravimetric analysis showed that the synthesized complexes have thermal stability and confirms the absence of coordina

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Inderlied, C. B., L. S. Young, and J. K. Yamada. "Determination of in vitro susceptibility of Mycobacterium avium complex isolates to antimycobacterial agents by various methods." Antimicrobial Agents and Chemotherapy 31, no. 11 (1987): 1697–702. http://dx.doi.org/10.1128/aac.31.11.1697.

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Komenan, Kassi, Ecra J. Elidjé, Gbery P. Ildevert, et al. "Multifocal Buruli Ulcer Associated with Secondary Infection in HIV Positive Patient." Case Reports in Medicine 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/348628.

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Buruli ulcer is a chronic and infectious skin disease, caused byMycobacterium ulcerans. It leads to large skin ulceration and sometimes bone infection which is responsible for deformities. Here, we report a case of multifocal form of Buruli ulcer associated with secondary infection in a 46-year-old human immunodeficiency virus (HIV) positive woman. The antimycobacterial drugs combined to surgery allowed curing this multifocal case and rose up two relevant issues: the susceptibility of immune reconstitution inflammatory syndrome (IRIS) occurrence andMycobacteriumdissemination. The deep immune d

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Pais, João P., Olha Antoniuk, David Pires, et al. "Synthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial N-Alkyl Nitrobenzamides." Pharmaceuticals 17, no. 5 (2024): 608. http://dx.doi.org/10.3390/ph17050608.

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Tuberculosis (TB) is a disease that plagues the frailest members of society. We have developed a family of N-alkyl nitrobenzamides that exhibit promising antitubercular activities and can be considered a structural simplification of known inhibitors of decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase (DprE1), an essential Mycobacterium tuberculosis (Mtb) enzyme and an emergent antitubercular target. Hereby, we report the development of these compounds via a simple synthetic methodology as well as their stability, cytotoxicity, and antitubercular activity. Studying their in vitro activity revea

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33

Winglee, Kathryn, Shichun Lun, Marco Pieroni, Alan Kozikowski, and William Bishai. "Mutation ofRv2887, amarR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 6873–81. http://dx.doi.org/10.1128/aac.01341-15.

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ABSTRACTDrug resistance is a major problem inMycobacterium tuberculosiscontrol, and it is critical to identify novel drug targets and new antimycobacterial compounds. We have previously identified an imidazo[1,2-a]pyridine-4-carbonitrile-based agent, MP-III-71, with strong activity againstM. tuberculosis. In this study, we evaluated mechanisms of resistance to MP-III-71. We derived three independentM. tuberculosismutants resistant to MP-III-71 and conducted whole-genome sequencing of these mutants. Loss-of-function mutations inRv2887were common to all three MP-III-71-resistant mutants, and we

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Tseng, Cheng-Yin, Mao-Feng Sun, Tsai-Chung Li, and Ching-Ting Lin. "Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus." Evidence-Based Complementary and Alternative Medicine 2020 (November 10, 2020): 1–9. http://dx.doi.org/10.1155/2020/9754357.

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Mycobacterium abscessus infections are notoriously difficult to be treated and newer treatment options are required. Coptis chinensis (C. chinensis) and its main compound berberine are frequently used to treat bacterial and viral infections. In this study, the susceptibility of M. abscessus to C. chinensis extract and berberine was assessed by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) evaluation. The effects of C. chinensis and berberine on biofilm formation and antibiotic susceptibility in M. abscessus were observed. C. chinensis at concentrations of

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35

Srinivas, A. "Anti-microbial susceptibility pattern of spores used in Bacillus clausii suspension: an in vitro study." International Journal of Contemporary Pediatrics 7, no. 5 (2020): 980. http://dx.doi.org/10.18203/2349-3291.ijcp20201511.

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Background: Bacillus species have been used as probiotics as they have high stability to gastrointestinal conditions and impart health benefit on the host. Primarily used in their spore form the diversity of Bacillus species being used and their applications are remarkable. Here, we present the results of the antimicrobial susceptibility testing of the B. clausii spore suspension (Benegut®).Methods: Bacillus clausii spore suspension (Benegut®), used in oral bacteriotherapy was tested for the susceptibility to therapeutically useful antibiotics. Twelve commercially prepared, paper antibiotic di

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Gebeyehu, Netsanet Azene, Solomie Jebessa Deribessa, Freeman Alexandra та ін. "Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-γ R1) Defect: A Clinical Diagnostic and Treatment Challenge". Case Reports in Infectious Diseases 2022 (23 вересня 2022): 1–8. http://dx.doi.org/10.1155/2022/6534009.

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Background. Mendelian susceptibility to mycobacterial diseases (MSMD) is an inborn error of immunity categorized as defects in intrinsic and innate immunity. MSMD is characterized by vulnerability to less virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccine strains, as well as environmental mycobacteria (EM). The definitive diagnosis is made by genetic analysis. Treatments constitute antimycobacterial, interferon-gamma, surgery, and hematopoietic stem cell transplantation (HSCT), which is the only known curative treatment. The mortality rate ranges from 40% to 80% depending on

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Zhang, Ying, Angelo Scorpio, Hiroshi Nikaido, and Zhonghe Sun. "Role of Acid pH and Deficient Efflux of Pyrazinoic Acid in Unique Susceptibility of Mycobacterium tuberculosis to Pyrazinamide." Journal of Bacteriology 181, no. 7 (1999): 2044–49. http://dx.doi.org/10.1128/jb.181.7.2044-2049.1999.

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ABSTRACT Pyrazinamide (PZA) is an important antituberculosis drug. Unlike most antibacterial agents, PZA, despite its remarkable in vivo activity, has no activity against Mycobacterium tuberculosis in vitro except at an acidic pH. M. tuberculosis is uniquely susceptible to PZA, but other mycobacteria as well as nonmycobacteria are intrinsically resistant. The role of acidic pH in PZA action and the basis for the unique PZA susceptibility of M. tuberculosisare unknown. We found that in M. tuberculosis, acidic pH enhanced the intracellular accumulation of pyrazinoic acid (POA), the active deriva

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Hart, Bryan E., and Richard I. Tapping. "Genetic Diversity of Toll-Like Receptors and Immunity toM. lepraeInfection." Journal of Tropical Medicine 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/415057.

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Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection withMycobacterium leprae. As expected, many of the polymorphisms reside within genes that encode components of the innate and adaptive immune system. Despite the preponderance of these studies, our understanding of the mechanisms that underlie these genetic associations remains sparse. Toll-like receptors (TLRs) have emerged as an essential family of innate immune pattern recognition receptors which play a pivotal role in host defense agains

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Alcaide, Fernando, Laura Calatayud, Miguel Santín, and Rogelio Martín. "Comparative In Vitro Activities of Linezolid, Telithromycin, Clarithromycin, Levofloxacin, Moxifloxacin, and Four Conventional Antimycobacterial Drugs against Mycobacterium kansasii." Antimicrobial Agents and Chemotherapy 48, no. 12 (2004): 4562–65. http://dx.doi.org/10.1128/aac.48.12.4562-4565.2004.

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ABSTRACT Mycobacterium kansasii is one of the most pathogenic and frequent nontuberculous mycobacteria isolated from humans. Patients with adverse drug reactions, resistant isolates, or suboptimal response require alternative treatment regimens. One hundred forty-eight consecutive clinical isolates of M. kansasii were tested for antimicrobial susceptibilities by the BACTEC 460 system (NCCLS) with two different inoculation protocols, one conventional and one alternative. In the alternative protocol, the inoculum 12B vial was incubated until the growth index was between 250 and 500. Four convent

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Bakuła, Zofia, Magdalena Modrzejewska, Lian Pennings, et al. "Drug Susceptibility Profiling and Genetic Determinants of Drug Resistance inMycobacterium kansasii." Antimicrobial Agents and Chemotherapy 62, no. 4 (2018): e01788-17. http://dx.doi.org/10.1128/aac.01788-17.

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ABSTRACTVery few studies have examined drug susceptibility ofMycobacterium kansasii, and they involve a limited number of strains. The purpose of this study was to determine drug susceptibility profiles ofM. kansasiiisolates representing a spectrum of species genotypes (subtypes) with two different methodologies, i.e., broth microdilution and Etest assays. To confirm drug resistance, drug target genes were sequenced. A collection of 85M. kansasiiisolates, including representatives of eight different subtypes (I to VI, I/II, and IIB) from eight countries, was used. Drug susceptibility against 1

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Lytvynenko, N. A., M. V. Pogrebna, Yu O. Senko, L. M. Protsyk, S. P. Korotchenko, and R. L. Liubevych. "Treatment of MDR-TB/HIV/CMV patients under individualized regimes of antimycobacterial therapy." Infusion & Chemotherapy, no. 4 (December 28, 2022): 52–58. http://dx.doi.org/10.32902/2663-0338-2022-4-52-58.

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BACKGROUND. Often in practice there are combinations of several diseases, or tuberculosis of the respiratory organs develops against the background of various comorbidities, including HIV. OBJECTIVE. To demonstrate best clinical practices for selecting the optimal individualized treatment regimen (ITR) in a patient with multidrug-resistant tuberculosis (MDR-TB) associated with HIV in the setting of severe immunosuppression and complicated by poor tolerability. MATERIALS AND METHODS. Presented clinical analysis of newly diagnosed generalized MDR-TB associated with HIV, treated for I

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Flesch, I., and S. H. Kaufmann. "Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis." Journal of Immunology 138, no. 12 (1987): 4408–13. http://dx.doi.org/10.4049/jimmunol.138.12.4408.

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Abstract Growth inhibition of the intracellular bacterial pathogens Mycobacterium bovis and M. tuberculosis by lymphokine-activated murine bone marrow macrophages was studied. Mycobacterial growth was assessed by the uptake of 3H-uracil or by determination of colony-forming units. Stimulation of macrophages with recombinant interferon-gamma (r-IFN-gamma) or with IFN-gamma-containing supernatants from antigen- or mitogen-stimulated T cells markedly reduced growth of M. bovis strain BCG Phipps or M. tuberculosis strain H37Rv. In contrast, M. tuberculosis strain Middelburg proved resistant to lym

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Solnier, Julia, Liam Martin, Sanjib Bhakta, and Franz Bucar. "Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species." Molecules 25, no. 3 (2020): 734. http://dx.doi.org/10.3390/molecules25030734.

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Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM) infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are limited due to the spread of antimicrobial resistance mechanism. Plant-derived natural compounds as prospective efflux pump inhibitors may present a promising adjunct to conventional chemotherapy by enhancing mycobacterial susceptibility to antibiotics. This study served to evaluate the antimicrobial and resistance-modifying profile of a range of plant-derived flavonoids against the mycobacterial model strains: M. smegma

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Eng, Hock-Liew, Huey-Ling You, Chiou-Huey Wang, Pei-Yi Su, and Tsun-Mei Lin. "Functional polymorphisms of TLR8 gene contribute to Mycobacterium tuberculosis infection (INC7P.401)." Journal of Immunology 192, no. 1_Supplement (2014): 186.2. http://dx.doi.org/10.4049/jimmunol.192.supp.186.2.

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Abstract Innate immunity is important for antimycobacterial defence through senses various pathogen-associated molecular patterns of Mycobacterium tuberculosis (MTB). Davila et al. first reported the evidence of association of TLR8 polymorphisms with tuberculosis (TB) susceptibility in males, but the mechanism through which TLR8 recognizes MTB and intracellular signaling remains unknown. In this study, we demonstrated that TLR8-129C /+1 A allele was present at higher frequency in males TB infected patients as compared to the healthy controls (24.1% vs. 6.8%, p=0.001) in Taiwan. Ex vivo phagocy

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Petrenko, V. I., O. V. Stopolyansky, Yа V. Bondarenko, et al. "Risk factors for lethal outcome in tuberculosisassociated immune reconstitution inflammatory syndrome with tuberculous lesions of the central nervous system." Tuberculosis, Lung Diseases, HIV Infection, no. 2 (June 29, 2021): 15–19. http://dx.doi.org/10.30978/tb2021-2-15.

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Objective — to study the relation of death in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and central nervous system (CNS) tuberculosis with the following factors: 1) baseline CD4+ T-lymphocyte count, cells/µL, at the beginning of treatment; 2) the level of viral load at the beginning of treatment; 3) resistance to antimycobacterial drugs (R, HR, HR + others) or its absence at the beginning of treatment; 4) age of patients; 5) gender of patients. Materials and methods. 55 cases of neurological TB-IRIS were analyzed. These patients were treated and observ

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Scanga, Charles A., Vellore P. Mohan, Kathryn Tanaka, David Alland, JoAnne L. Flynn, and John Chan. "The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice." Infection and Immunity 69, no. 12 (2001): 7711–17. http://dx.doi.org/10.1128/iai.69.12.7711-7717.2001.

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ABSTRACT Murine macrophages effect potent antimycobacterial function via the production of nitric oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2). The protective role of reactive nitrogen intermediates (RNI) against Mycobacterium tuberculosisinfection has been well established in various murine experimental tuberculosis models using laboratory strains of the tubercle bacillus to establish infection by the intravenous route. However, important questions remain about the in vivo importance of RNI in host defense against M. tuberculosis. There is some evidence that RNI p

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Lee, S., D. H. Kong, S. H. Yun, et al. "Evaluation of a modified antimycobacterial susceptibility test using Middlebrook 7H10 agar containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride." Journal of Microbiological Methods 66, no. 3 (2006): 548–51. http://dx.doi.org/10.1016/j.mimet.2006.02.004.

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Peloquin, Charles A. "Controversies in the Management of Mycobacterium Avium Complex Infection in AIDS Patients." Annals of Pharmacotherapy 27, no. 7-8 (1993): 928–37. http://dx.doi.org/10.1177/106002809302700722.

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OBJECTIVE: To update readers on the clinical management of infections secondary to Mycobacterium avium complex (MAC) in patients with AIDS. A general description of the organism, culture and susceptibility testing, and clinical manifestations of the disease is provided. Several aspects of the treatment of the disease, including an historical perspective, current approaches, and future research opportunities, are described. DATA SOURCES: Current medical literature, including abstracts presented at international meetings, is reviewed. References were identified through MEDLINE, Current Contents,

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Schwander, Stephan, Srijata Sarkar, Youngmia Song та ін. "Suppression of the NF-κB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity (117.4)". Journal of Immunology 188, № 1_Supplement (2012): 117.4. http://dx.doi.org/10.4049/jimmunol.188.supp.117.4.

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Abstract Chronic exposure to air pollution increases susceptibility to respiratory infections including tuberculosis in humans. We hypothesized that exposure to diesel exhaust particles (DEP), a major component of urban fine particulate matter, suppresses antimycobacterial human immune effector cell functions by modulating TLR-signaling pathways and NF-κB activation. To examine the effects of DEP on M.tb-induced host immunity, PBMC from 20 healthy persons [13 m, 7 f, mean age 33.5 years) were stimulated with DEP and M.tb or PPD (purified protein derivative). We show by TEM studies that both DE

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Klemens, S. P., C. A. Sharpe, and M. H. Cynamon. "Activity of pyrazinamide in a murine model against Mycobacterium tuberculosis isolates with various levels of in vitro susceptibility." Antimicrobial Agents and Chemotherapy 40, no. 1 (1996): 14–16. http://dx.doi.org/10.1128/aac.40.1.14.

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The activity of pyrazinamide (PZA) against eight isolates of Mycobacterium tuberculosis in a murine infection model was evaluated. M. tuberculosis isolates with various degrees of in vitro susceptibility to PZA (MIC range, 32 to > 2,048 micrograms/ml) were used. Four-week-old female mice were infected intravenously with approximately 10(7) viable M. tuberculosis organisms. PZA at 150 mg/kg of body weight was started 1 day postinfection and given 5 days/week for 4 weeks. Infected but untreated mice were compared with PZA-treated mice. Mice were sacrificed at the completion of the treatment p

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