Relevant bibliographies by topics / Antineoplastic antibiotics Diels-Alder reaction

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Academic literature on the topic 'Antineoplastic antibiotics Diels-Alder reaction'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "Antineoplastic antibiotics Diels-Alder reaction"

1

Caygill, Graham B., David S. Larsen, and Brett S. McFarlane. "Synthetic Approaches to the Angucycline Antibiotics: A Synthesis of (±)-Hatomarubigin B and C." Australian Journal of Chemistry 50, no. 4 (1997): 301. http://dx.doi.org/10.1071/c96106.

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The synthesis of the angucycline natural products hatomarubigin B and C in racemic form is described. The key step in the construction of the benz[a]anthraquinone skeleton of these molecules was the Diels–Alder reaction of the acetate of (E,1R*,5R*)-3-(2′-methoxyvinyl)-5-methylcyclohex-2-en-1-ol and 5-acetoxy-8-hydroxy-1,4-naphthoquinone. Methylation of the C11 phenolic group of the resulting cycloadduct, followed by aromatization of the B ring with subsequent deacylation gave (±)-hatomarubigin C. Oxidation of the latter compound with Dess-Martin periodinane, 1,1,1-triacetoxy-1,1-dihydro-1,2-b
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Fejes, Zsolt, Attila Mándi, István Komáromi, László Majoros, Gyula Batta, and Pál Herczegh. "A synthetic and in silico study on the highly regioselective Diels–Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin." Tetrahedron Letters 51, no. 38 (2010): 4968–71. http://dx.doi.org/10.1016/j.tetlet.2010.07.049.

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3

Kitani, Yasuo, Akiko Morita, Takuya Kumamoto, and Tsutomu Ishikawa. "Synthetic Studies on Kinamycin Antibiotics: Synthesis of a Trioxygenated Benz[f]indenone and its Diels–Alder Reaction to a Kinamycin Skeleton." Helvetica Chimica Acta 85, no. 4 (2002): 1186. http://dx.doi.org/10.1002/1522-2675(200204)85:4<1186::aid-hlca1186>3.0.co;2-q.

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Kitani, Yasuo, Akiko Morita, Takuya Kumamoto, and Tsutomu Ishikawa. "ChemInform Abstract: Synthetic Studies on Kinamycin Antibiotics: Synthesis of a Trioxygenated Benz[f]indenone and Its Diels-Alder Reaction to a Kinamycin Skeleton." ChemInform 33, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.200237233.

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Dissertations / Theses on the topic "Antineoplastic antibiotics Diels-Alder reaction"

1

Osman, Hasnah, and n/a. "Synthetic approaches to the angucycline antibiotics." University of Otago. Department of Chemistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070426.160307.

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The stereoselective synthesis of urdamycinone B (17) was achieved in a 21% overall yield from C-glycosyl-naphthoquinone 197. The key reaction was the Diels-Alder cycloaddition reaction of 197 and siloxydiene (�)-117 promoted by a chiral Lewis acid derived from (S)-3,3�-diphenyl-1,1�-binaphthalene-2,2�-diol (291), BH₃.THF and acetic acid. An effective kinetic resolution of (�)-117 occurred. Four cycloadducts 199a-d were formed in a ratio between 84:8:2:6 and 70:9:2:19. Aromatisation of the mixture by treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) gave 200a and 200b in 4:1 ratio. A sequ
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2

Morrison, Christopher F. "Efforts directed towards an asymmetric total synthesis of the antitumor antibiotic Fredericamycin A and a study of the Diels-Alder reactions of a carvone-derived diene /." 2001.

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3

Ψαρρά, Βασιλική. "Μελέτες με σκοπό την ολική σύνθεση της Ecteinascidin 743 : νέες συνθετικές μεθοδολογίες στη φαρμακευτική χημεία". Thesis, 2009. http://nemertes.lis.upatras.gr/jspui/handle/10889/2901.

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Η Ecteinascidin 743 είναι ένα σπουδαίο αντικαρκινικό φάρμακο, που καταστρέφει μέσω αλκυλίωσης τα καρκινικά κυττάρα και είναι εμπορικά διαθέσιμο με το όνομα Yondelis. Χρησιμοποιείται στην Ευρώπη, τη Ρωσία και τη Νότια Κορέα για τη θεραπεία του σαρκώματος του μαλακού ιστού, δηλαδή καρκίνου των ιστών που υποστηρίζουν το σώμα, όπως οι μύες, τα αιμοφόρα αγγεία και άλλα είδη ιστών που υποστηρίζουν και προστατεύουν τα όργανα του σώματος. Η Ecteinascidin 743 βρίσκεται υπό κλινικές δοκιμές για τη θεραπεία και άλλων μορφών καρκίνου, όπως του καρκίνου του μαστού, του προστάτη, των ωοθηκών, των νεφ
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Books on the topic "Antineoplastic antibiotics Diels-Alder reaction"

1

Maier, Martin. Hetero-Diels-Alder Reaktionen mit inversem Elektronenbedarf zur Synthese von Hexopyranosiden. Hartung-Gorre, 1985.

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