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Relevant bibliographies by topics / Antineoplastic Methotrexate Cell line

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Academic literature on the topic 'Antineoplastic Methotrexate Cell line'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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Journal articles on the topic "Antineoplastic Methotrexate Cell line"

1

Ciaiolo, Carlo, Dario Ferrero, Agostino Pugliese, et al. "Enhancement of Methotrexate Cytotoxicity by Modulation of Proliferative Activity in Normal and Neoplastic t Lymphocytes and in a Myeloid Leukemia Cell Line." Tumori Journal 74, no. 5 (1988): 537–42. http://dx.doi.org/10.1177/030089168807400507.

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Recent advances in the modulation of cell kinetics with growth factors suggest that the effect of cyclespecific cytostatic drugs can be enhanced by combination with such factors. The truth of this hypothesis was investigated by studying the effect of phytohemoagglutinin and/or interlenkin 2 on the sensitivity to methotrexate (MTX) of normal T lymphocytes and of lymphoblastis of a patient with acute T-cell lymphoid leukemia. In both cases, inhibition of proliferation by MTX was increased from less than 30% in resting cells or those sub-optimally stimulated, in the case of leukemic blasts, to 68

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Miyashita, T., and JC Reed. "Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line." Blood 81, no. 1 (1993): 151–57. http://dx.doi.org/10.1182/blood.v81.1.151.151.

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Abstract Previous studies have shown that the bcl-2 gene encodes a mitochondrial protein that contributes to neoplastic cell expansion primarily by promoting cell survival through interference with “programmed cell death” (PCD), also termed “apoptosis.” Because many chemotherapeutic drugs are capable of initiating pathways leading to apoptosis, we determined whether deregulated bcl-2 expression could render cells resistant to several drugs commonly used in the treatment of non- Hodgkin's lymphomas, including dexamethasone (DEX), methotrexate (MTX), 1-beta-D-arabinofuranosyl-cytosine (Ara-C), e

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Miyashita, T., and JC Reed. "Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line." Blood 81, no. 1 (1993): 151–57. http://dx.doi.org/10.1182/blood.v81.1.151.bloodjournal811151.

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Previous studies have shown that the bcl-2 gene encodes a mitochondrial protein that contributes to neoplastic cell expansion primarily by promoting cell survival through interference with “programmed cell death” (PCD), also termed “apoptosis.” Because many chemotherapeutic drugs are capable of initiating pathways leading to apoptosis, we determined whether deregulated bcl-2 expression could render cells resistant to several drugs commonly used in the treatment of non- Hodgkin's lymphomas, including dexamethasone (DEX), methotrexate (MTX), 1-beta-D-arabinofuranosyl-cytosine (Ara-C), etoposide

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4

Kothari, Shalin, Daniel Gustafson, Keith Killian, et al. "COXEN prediction of antineoplastic drug sensitivity in bladder cancer patients." Journal of Clinical Oncology 34, no. 2_suppl (2016): 365. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.365.

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365 Background: COXEN (Co-eXpression ExtrapolatioN) uses molecular profiles as a “rosetta stone” for translating drug sensitivities of one set of cancers into predictions for another completely independent set of cell lines or human tumors. The ability of COXEN to predict drug effectiveness in pts using tumor samples from in vitro assays is unique. Methods: We tested the predictive value of COXEN for standard chemotherapies in a cohort of bladder cancer pts. Total RNA was extracted from formalin fixed paraffin embedded (FFPE) tissue and converted to cDNA, amplified with Ovation FFPE WTA, and h

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Eischen, Christine M., Timothy J. Kottke, Luis M. Martins, et al. "Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions." Blood 90, no. 3 (1997): 935–43. http://dx.doi.org/10.1182/blood.v90.3.935.

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Abstract The Fas/Fas ligand (FasL) pathway is widely involved in apoptotic cell death in lymphoid and nonlymphoid cells. It has recently been postulated that many chemotherapeutic agents also induce cell death by activating the Fas/FasL pathway. In the present study we compared apoptotic pathways induced by anti-Fas or chemotherapeutic agents in the Jurkat human T-cell leukemia line. Immunoblotting showed that treatment of wild-type Jurkat cells with anti-Fas or the topoisomerase II-directed agent etoposide resulted in proteolytic cleavage of precursors for the cysteine-dependent aspartate-dir

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Eischen, Christine M., Timothy J. Kottke, Luis M. Martins, et al. "Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions." Blood 90, no. 3 (1997): 935–43. http://dx.doi.org/10.1182/blood.v90.3.935.935_935_943.

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The Fas/Fas ligand (FasL) pathway is widely involved in apoptotic cell death in lymphoid and nonlymphoid cells. It has recently been postulated that many chemotherapeutic agents also induce cell death by activating the Fas/FasL pathway. In the present study we compared apoptotic pathways induced by anti-Fas or chemotherapeutic agents in the Jurkat human T-cell leukemia line. Immunoblotting showed that treatment of wild-type Jurkat cells with anti-Fas or the topoisomerase II-directed agent etoposide resulted in proteolytic cleavage of precursors for the cysteine-dependent aspartate-directed pro

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Bayraktar, Ulas D., Roberto Ochoa, Soley Bayraktar, Maria Matsangou, and Juan Carlos Ramos. "High-Dose Methotrexate and Azidothymidine in Combination with Alternating DA-EPOCH Is An Effective Regimen for the Treatment of EBV-Related Plasmablastic Lymphoma." Blood 114, no. 22 (2009): 4753. http://dx.doi.org/10.1182/blood.v114.22.4753.4753.

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Abstract Abstract 4753 Introduction Plasmablastic lymphoma (PBL) is an aggressive and generally fatal, rare type of B-cell non-Hodgkin's lymphoma (NHL) with predilection to sino-oral mucosa. PBL is usually associated with human immunodeficiency virus (HIV) and displays an unusual phenotype lacking the expression of B-cell surface antigens. PBLs are infected by Epstein Barr virus (EBV) in approximately 80% of cases and exhibit a restricted pattern of EBV gene expression as they do not typically express latent membrane proteins (LMPs), which enforce viral latency. Azidothymidine (AZT), a thymidi

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Melguizo, C., J. Prados, J. Aneiros, J. E. Fernandez, C. Velez, and A. Aranega. "Differentiation of a human rhabdomyosarcoma cell line after antineoplastic drug treatment." Journal of Pathology 175, no. 1 (1995): 23–29. http://dx.doi.org/10.1002/path.1711750105.

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Caldito, Elena G., Jay M. Pescatore, and Maha Elsebaie. "Severe multiorgan toxicity after first dose of Capizzi methotrexate in a young adult patient with acute lymphocytic leukaemia." BMJ Case Reports 14, no. 7 (2021): e243153. http://dx.doi.org/10.1136/bcr-2021-243153.

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Methotrexate is a versatile antineoplastic and immunosuppressive agent. We report a case of a young adult on the Cancer and Leukaemia Group B 10403 treatment protocol for B-cell acute lymphoblastic leukaemia. She has previously completed the induction and consolidation phases with good tolerance then started on Capizzi methotrexate during the interim maintenance phase. Few days after receiving one intermediate dose of methotrexate, she developed severe multiorgan toxicities including pancytopaenia and several dermatologic toxicities. The patient underwent extensive diagnostic workup, with all

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Virdis, Patrizia, Rossana Migheli, Grazia Galleri, et al. "Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line." Tumor Biology 42, no. 2 (2020): 101042831990106. http://dx.doi.org/10.1177/1010428319901061.

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Burkitt lymphoma is a very aggressive B-cell non-Hodgkin lymphoma. Although remarkable progress has been made in the therapeutic scenario for patients with Burkitt lymphoma, search and development of new effective anticancer agents to improve patient outcome and minimize toxicity has become an urgent issue. In this study, the antitumoral activity of Inula viscosa, a traditional herb obtained from plants collected on the Asinara Island, Italy, was evaluated in order to explore potential antineoplastic effects of its metabolites on Burkitt lymphoma. Raji human cell line was treated with increasi

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Dissertations / Theses on the topic "Antineoplastic Methotrexate Cell line"

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Fotoohi, Alan Kambiz. "Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-087-9/.

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Yu, Weiping. "Mechanisms of RRR-[alpha]-tocopheryl succinate (VES) induction of growth inhibition and apoptosis in the human breast cancer cell line, MDA-MB-435 /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Lindskog, Magnus. "Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-160-1/.

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Shor, Audrey Cathryn. "Src kinase inhibitors for the treatment of sarcomas : cellular and molecular mechanisms of action." [Tampa, Fla] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001906.

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Kinkade, Rebecca. "Rb-Raf-1 interaction as a therapeutic target for proliferative disorders." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002426.

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Charcosset, Jean-Yves. "Etude sur le mécanisme d'action de dérivés de l'ellipticine sur des cellules en culture sensibles et résistantes à la 9-hydroxyellipticine." Paris 6, 1986. http://www.theses.fr/1986PA066109.

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Salord, Jérôme. "L'ecto-nad**(+) glycohydrolase : une cible cellulaire specifique pour le pilotage de molecules bio-actives au moyen de liposomes." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13083.

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Nous avons mis au point un systeme de ciblage de molecules bio-actives au moyen de liposomes, base sur la reconnaissance entre une ecto-enzyme et un ligand de petite taille greffe de maniere covalente sur des vesicules preformees. L'ecto-nad**(+) glycohydrolase (e. C. 3. 2. 2. 6) a ete choisie comme cible cellulaire pour des liposomes porteurs a leur surface du (3,4-(ch3)2)pdad**(+), inhibiteur competitif de l'enzyme. En vue du couplage covalent, le ligand a ete derivatise en position n**(6) de l'adenine par un bras hydrophile espaceur termine par une fonction thiol, destine a reagir avec des

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Craperi, Delphine. "Thérapie génique des gliomes : caractérisation des voies cytotoxiques déclenchées par le système thymidine kinase herpétique/ganciclovir." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10073.

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La therapie genique par transfert du gene de la thymidine kinase du virus de l'herpes simplex de type 1 (hsv1-tk) suivi d'un traitement avec la prodrogue ganciclovir (gcv) a ete utilisee pour le traitement de divers cancers. L'efficacite de cette therapie est en partie due a l'existence d'un effet de toxicite de voisinage : le traitement au ganciclovir entraine non seulement la mort des cellules exprimant hsv1-tk mais aussi celle des cellules adjacentes non transfectees. Nous avons entrepris une etude in vitro des mecanismes moleculaires de la toxicite de ce systeme enzyme/prodrogue sur des li

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Agarwal, Nitin Kumar. "Proteome-wide Identification of New Molecular Targets Affected by Methotrexate in Acute Promyelocytic Leukaemia Cell Line." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F227-3.

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"The anti-cancer activities of paeoniae radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms." 2004. http://library.cuhk.edu.hk/record=b6073630.

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Li Lok Yee Mandy.<br>"June 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 155-165).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Books on the topic "Antineoplastic Methotrexate Cell line"

1

B, Roninson Igor, ed. Molecular and cellular biology of multidrug resistance in tumor cells. Plenum Press, 1991.

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Book chapters on the topic "Antineoplastic Methotrexate Cell line"

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Lee, In Seon, Soo Un Kim, Yun Sik Lee, Sung Hui Park, and In Ja Rhee. "Molecular Mechanisms of Selaginella Tamariscina for Antineoplastic Activity in Human Leukemia Cell Line U937." In Animal Cell Technology: Basic & Applied Aspects. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5161-0_15.

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Mandelbaum-Shavit, Frederika. "Up-Regulated Transport of Methotrexate and 5-Methyltetrahydrofolate in a Human Breast Cancer Cell Line." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2960-6_165.

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Williams, Frederick E., Manohar Ratnam, Terence P. McAlinden, Gerrit Jansen, Jan H. Schornagel, and James H. Freisheim. "Transformation of an L-Cell Line with the DNA Coding for the Reduced-Folate/Methotrexate Transporter Protein from a CCRF-CEM Human Leukemia Cell Line." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2960-6_163.

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Tanizawa, Akihiko, Masaru Kubota, Tetsuya Takimoto, et al. "Sequential Combination of Methotrexate and 1-β-D-Arabinofuranosylcytosine Shows Synergistic Effect on the Generation of DNA Strand Breaks in a Human Promyelocytic Leukemia Cell Line." In Advances in Experimental Medicine and Biology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5676-9_51.

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Sinacore, M. S., S. Brodeur, S. Brennan, M. Fallon, S. R. Adamson, and D. Cohen. "Population analysis of a recombinant Chinese hamster ovary cell line expressing recombinant human protein cultured in the presence and absence of methotrexate selective pressure." In Animal Cell Technology. Elsevier, 1994. http://dx.doi.org/10.1016/b978-0-7506-1845-8.50015-6.

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6

"Effect of vincristine on methotrexate cytotoxicity and accumulation in MCF-7 cells, a human breast cancer cell line." In Zurich, Switzerland, September 3–8, 1989. De Gruyter, 1990. http://dx.doi.org/10.1515/9783110889000-220.

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7

"Use of CI-920 in the Characterization of the Methotrexate Transport Defect in a Resistant Human Leukemic CCRF-CEM Cell Line." In Montreal, Canada, June 15–20, 1986. De Gruyter, 1986. http://dx.doi.org/10.1515/9783110856262-102.

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8

Cocchia, Rosangela, Riccardo Gorla, and Eduardo Bossone. "Aortitis: infectious and non-infectious diseases." In ESC CardioMed, edited by Raimund Erbel. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0625.

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Aortitis includes infectious or more frequently non-infectious conditions leading to inflammation of the aorta. This represents a rare but potentially risky disease since it can be complicated by acute aortic syndromes and thrombosis. Non-infectious aortitis in most cases is associated with rheumatological conditions and in particular, is more frequent in giant cell arteritis and in Takayasu arteritis. It may also occasionally follow an endovascular aortic repair. Given the non-specific symptoms and physical signs, a high clinical index of suspicion is necessary to detect the disease. In the majority of cases, erythrocyte sedimentation rate and C-reactive protein level may be increased, reflecting disease activity. However, an integrated multimodality approach remains essential in order to confirm the diagnosis, detect life-threatening complications, and guide therapeutic interventions. In non-infectious aortitis, corticosteroids (prednisone) represent the first-line initial and long-term therapy. Second-line agents include methotrexate, azathioprine, and anti-tumour necrosis factor-alpha agents. However, in a substantial number of cases disease relapse may occur, requiring additional immunosuppression.

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Conference papers on the topic "Antineoplastic Methotrexate Cell line"

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Duran, Gulay Gulbol, Nizami Duran, Emrah Ay, Durmus Alpaslan Kaya, and Madalina Georgiana Albu Kaya. "Synergistic Activities of the Essential Oils Hypericum Perforatum with Methotrexate on Human Breast Cancer Cell Line MCF-7." In The 6th International Conference on Advanced Materials and Systems. INCDTP - Division: Leather and Footwear Research Institute, Bucharest, RO, 2016. http://dx.doi.org/10.24264/icams-2016.ii.9.

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