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Journal articles on the topic 'Antioxidant abuse'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Berríos-Cárcamo, Pablo, Mauricio Quezada, María Elena Quintanilla, et al. "Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules." Antioxidants 9, no. 9 (2020): 830. http://dx.doi.org/10.3390/antiox9090830.

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Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, all drugs of abuse promote the activation of the brain reward system, with lasting neurobiological consequences that potentiate subsequent consumption. Recent evidence shows that the brain displays marked oxidative stress and neuroinflammation following chronic drug consumption. Brain oxidative stress and neuroinflammation disrupt glutamate homeostasis by impairing synaptic an

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Ige, A. O., D. T. Oluwole, M. O. Olaoye, and E. O. Adewoye. "Testicular function following oral exposure to Tramadol and Cannabis sativa ethanol extracts in male Wistar rats." Research Journal of Health Sciences 8, no. 2 (2020): 63–72. http://dx.doi.org/10.4314/rejhs.v8i2.2.

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Objective: Substance abuse is a global challenge. This study investigated the effects of two commonly abused substances, tramadol and/or Cannabis sativa ethanol extracts (ECS), on testicular function in Wistar male rats.Methods: Twenty-animals were equally divided into 4groups that received 0.9%NaCl (0.2ml), tramadol (40mg/kg), ECS (2mg/kg) and tramadol + ECS for 30days, respectively (daily p.o). Following anesthesia, blood samples were obtained and serum testosterone was determined. Testes and epididymis were harvested and weighed. Sperm motility, viability and counts were evaluated in the ep

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Saribal, Devrim, Fatma Sinem Hocaoglu-Emre, Fulya Karaman, Hasan Mırsal, and Mehmet Can Akyolcu. "Trace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuse." Biological Trace Element Research 193, no. 1 (2019): 7–13. http://dx.doi.org/10.1007/s12011-019-01681-y.

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Ramirez, Servio H., Raghava Potula, Shongshan Fan, et al. "Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells." Journal of Cerebral Blood Flow & Metabolism 29, no. 12 (2009): 1933–45. http://dx.doi.org/10.1038/jcbfm.2009.112.

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Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects. Recent studies in animal models have indicated that METH can induce impairment of the blood–brain barrier (BBB), thus suggesting that some of the neurotoxic effects resulting from METH abuse could be the outcome of barrier disruption. In this study, we provide evidence that METH alters BBB function through direct effects on endothelial cells and explore possible underlying mechanisms leading to endothelial injury. We report that METH increases BBB permeabi

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Duranti, Guglielmo, Roberta Ceci, Luigi Di Luigi, et al. "Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 9962. http://dx.doi.org/10.3390/ijerph18199962.

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Background: The phosphodiesterase type 5 inhibitor (PDE5I) tadalafil, in addition to its therapeutic role, has shown antioxidant effects in different in vivo models. Supplementation with antioxidants has received interest as a suitable tool for preventing or reducing exercise-related oxidative stress, possibly leading to the improvement of sport performance in athletes. However, the use/abuse of these substances must be evaluated not only within the context of amateur sport, but especially in competitions where elite athletes are more exposed to stressful physical practice. To date, very few h

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Arto, Sastha Sugih, and Reynatha C. A. Pangsibidang. "Review of natural antioxidant plants to overcome the neurotoxic effects of methamphetamine." Pharmacy Education 24, no. 6 (2024): 59–72. http://dx.doi.org/10.46542/pe.2024.246.5972.

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Background: Methamphetamine (METH) is a psychostimulant substance known for its substantial abuse potential and neurotoxic properties. METH is a second-line drug in certain conditions such as Attention Deficit Hyperactivity Disorder (ADHD), severe obesity, or narcolepsy. Objective: This study aims to compare natural plant antioxidants to overcome neurotoxicity caused by methamphetamine. Method: The authors used a literature review method and collected articles from "PubMed", "Google Scholar", "ScienceDirect", "Scopus" from 2010 - 2023 without excluding old works that are often cited and truste

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Baliño, Pablo, Ricard Romero-Cano, and María Muriach. "Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome." International Journal of Molecular Sciences 22, no. 2 (2021): 807. http://dx.doi.org/10.3390/ijms22020807.

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Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects of ethanol abuse and metabolic syndrome at a central level have not yet been elucidated in detail. Thus, this work aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Seven-week-old male control (B6.V-Lep

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Deka, Kamala, Anju Moni Rabha, and Mainak Roy. "Association of vitamin D and antioxidant enzyme levels in patients with delirium tremens: A case control study." Industrial Psychiatry Journal 33, no. 2 (2024): 285–91. https://doi.org/10.4103/ipj.ipj_25_24.

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Background: Global alcohol consumption poses a serious threat to humankind. It is estimated that between 5% and 7% of Indian adults struggle with alcohol abuse. Alcoholism is associated with a number of disorders, impacting different organ systems and nutritional status, including symptoms of withdrawal that can vary in severity from moderate symptoms to delirium tremens (DT). An increase in oxidative stress in the body is linked to alcohol withdrawal. Aim: This study aimed to evaluate the role of vitamins with antioxidant properties on oxidative stress caused by the severe alcohol withdrawal

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Sandoval, Cristian, Jorge Farías, Mauricio Zamorano, and Christian Herrera. "Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review." Antioxidants 11, no. 3 (2022): 564. http://dx.doi.org/10.3390/antiox11030564.

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Several studies have shown that blood vitamin levels are low in alcoholic patients. In effect, alcohol use abuse is considered a chronic disease that promotes the pathogenesis of many fatal diseases, such as cancer and liver cirrhosis. The alcohol effects in the liver can be prevented by antioxidant mechanisms, which induces enzymatic as well as other nonenzymatic pathways. The effectiveness of several antioxidants has been evaluated. However, these studies have been accompanied by uncertainty as mixed results were reported. Thus, the aim of the present review article was to examine the curren

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C.O, Akintayo, Olukiran O.S, Ayodele M.J, and Karga S.V. "Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats." Journal of Drug Metabolism & Toxicology 14, no. 1 (2023): 5. https://doi.org/10.35248/2157-7609.23.14.271.

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Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and prevalence of use continues to grow. Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats. Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5 rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA. Results: The serum concentrations of AST and

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Patil, Siddappa A., Aravind R. Nesaragi, Raúl R. Rodríguez-Berrios, Sydney M. Hampton, Alejandro Bugarin, and Shivaputra A. Patil. "Coumarin Triazoles as Potential Antimicrobial Agents." Antibiotics 12, no. 1 (2023): 160. http://dx.doi.org/10.3390/antibiotics12010160.

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Currently, in hospitals and community health centers, microbial infections are highly common diseases and are a leading cause of death worldwide. Antibiotics are generally used to fight microbial infections; however, because of the abuse of antibiotics, microbes have become increasingly more resistant to most of them. Therefore, medicinal chemists are constantly searching for new or improved alternatives to combat microbial infections. Coumarin triazole derivatives displayed a variety of therapeutic applications, such as antimicrobial, antioxidant, and anticancer activities. This review summar

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Saleh, Amro. "Gastroprotective and Antioxidative Effects of Ammi Visnaga Extract Against Ethanol-induced Gastric Mucosal Ulceration in Male Albino Rats." Iranian Journal of Toxicology 17, no. 2 (2023): 137–46. http://dx.doi.org/10.32598/ijt.17.2.1066.1.

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Background: Alcohol abuse contributes to the pathology of gastric ulcers. The tissues contain antioxidants, but the activity declines when exposed to reactive oxygen species. The Ammi visnaga extract has substantial scavenging effects and is rich in phenols and flavonoids. We estimated the gastro-protective and antioxidative effects of A. visnaga extract on rats’ gastric mucosal lesions after exposure to ethanol. Methods: Forty adult male albino rats were divided into four groups of ten each. Group 1 (standard control), group 2 received omeprazole 20 mg/kg+1 mL ethanol, group 3 (ulcer model) r

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Sara BA, Abdaldafi, Ahamed Esraa MA, lsbaih Azza HA, et al. "Antimicrobial, Antioxidant Activities, and Phytochemical Characterization of Acacia nilotica and Hibiscus sabdariffa." International Journal of Agricultural Science and Food Technology 10, no. 1 (2024): 001–5. http://dx.doi.org/10.17352/2455-815x.000201.

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Antibiotic abuse has caused the emergence of an alarming number of resistant pathogens. Hence, there is an urgent need for novel agents. Most of the Sudanese people in rural areas rely on traditional medicine for the treatment of many infectious diseases. This study was carried out to investigate the antimicrobial antioxidant activities and phytochemical contents of Hibiscus sabdariffa fruits and Acacia nilotica pods. Antimicrobial assays of the ethanolic extracts of both plants showed that they exhibit diverse inhibitory activity against Gram-positive Staphylococcus aureus, and three Gram-neg

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Joshi, Pratibha C., and David M. Guidot. "The alcoholic lung: epidemiology, pathophysiology, and potential therapies." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 4 (2007): L813—L823. http://dx.doi.org/10.1152/ajplung.00348.2006.

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Epidemiological evidence gathered only in the past decade reveals that alcohol abuse independently increases the risk of developing the acute respiratory distress syndrome by as much as three- to fourfold. Experimental models and clinical studies are beginning to elucidate the mechanisms underlying this previously unrecognized association and are revealing for the first time that chronic alcohol abuse causes discrete changes, particularly within the alveolar epithelium, that render the lung susceptible to acute edematous injury in response to sepsis, trauma, and other inflammatory insults. Rec

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Derme, Martina, Martina Briante, Mauro Ceccanti, et al. "Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The Role of the Oxidative Stress—A Review of the Literature." Children 11, no. 3 (2024): 269. http://dx.doi.org/10.3390/children11030269.

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Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis. This narra

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Opuwari, Chinyerum S., and Ralf R. Henkel. "An Update on Oxidative Damage to Spermatozoa and Oocytes." BioMed Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/9540142.

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On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential cellular functions including the function of germ cells (oocytes and spermatozoa) and thereby the fertilization process. However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. Numerous causes are responsible for the delicate bodily redox system being out of balance and causing disease and infertility. M

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Jurič, Andreja, Blanka Tariba Lovaković, Antonio Zandona, et al. "The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells." Archives of Industrial Hygiene and Toxicology 74, no. 2 (2023): 106–14. http://dx.doi.org/10.2478/aiht-2023-74-3727.

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Abstract Ketamine is a dissociative anaesthetic used to induce general anaesthesia in humans and laboratory animals. Due to its hallucinogenic and dissociative effects, it is also used as a recreational drug. Anaesthetic agents can cause toxic effects at the cellular level and affect cell survival, induce DNA damage, and cause oxidant/antioxidant imbalance. The aim of this study was to explore these possible adverse effects of ketamine on hepatocellular HepG2 and neuroblastoma SH-SY5Y cells after 24-hour exposure to a concentration range covering concentrations used in analgesia, drug abuse, a

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Samuhasaneeto, Suchittra, Chuchard Punsawad, and Prapaporn Chaniad. "Protective Effects of Glochidion wallichianum Mull. Arg. on Ethanol-induced Liver Injury in Rats." Trends in Sciences 19, no. 12 (2022): 4609. http://dx.doi.org/10.48048/tis.2022.4609.

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Chronic ethanol consumption leads to the development of liver disease. In the present study, the effects of Glochidion wallichianum Mull. Arg. ethanol extract (GWE) on chronic ethanol-induced liver injury in rats were evaluated. Total phenolic and flavonoid contents and in vitro antioxidant activities were determined. In the in vivo experiment, male Wistar rats were divided into 5 groups: Control, ethanol, ethanol plus low and high doses of GWE (ethanol+GWE300 and ethanol+GWE600, respectively) and GWE alone (GWE600). All treatments were administered orally for 28 days. Serum biochemical profil

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L, Lipoksenla, Viswedenu Kera, Sunit Nath, et al. "Melissa Officinalis: A Review on the Antioxidant, Anxiolytic, and Anti-depressant Activity." Biosciences Biotechnology Research Asia 21, no. 2 (2024): 491–500. http://dx.doi.org/10.13005/bbra/3241.

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ABSTRACT: Anxiety and depression are among the most prevalent neuropsychiatric disorders globally and significantly contribute to the healthcare burden. Various factors, like stressful events, family history, substance abuse, health issues, hormonal imbalances, inflammation, and reactive oxygen species (ROS) mediated oxidative stress. Although numerous medications are available, their efficacy may diminish over time or vary among individuals. Phytomedicine offers a promising approach, focusing on herbal remedies with multiple therapeutic modalities. Melissa Officinalis (MO), a member of the La

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Ibrahim, Marwan Abdel-Latif, and Alaa-Eldin Salah-Eldin. "Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats." Pharmacology 103, no. 3-4 (2019): 202–11. http://dx.doi.org/10.1159/000496424.

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Aim: The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats due to the chronic usage of tramadol and the effect of its withdrawal. Method: Adult male albino rats were classified into the following 3 groups: (I) a control administered with normal saline and (II) tramadol-treated rats (40 mg/kg b.w. orally) for 21 successive days; and (III) like the rats in the second group but kept for 4 weeks after the last tramadol dose to study the effect of tramadol withdrawal. At the end of the experimental period, blood was collected and specimens from

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Fiore, Marco, Marisa Patrizia Messina, Carla Petrella, et al. "Antioxidant properties of plant polyphenols in the counteraction of alcohol-abuse induced damage: Impact on the Mediterranean diet." Journal of Functional Foods 71 (August 2020): 104012. http://dx.doi.org/10.1016/j.jff.2020.104012.

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Graziani, Manuela, Paolo Sarti, Marzia Arese, Maria Chiara Magnifico, Aldo Badiani, and Luciano Saso. "Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/3034245.

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Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activ

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Saensouk, Surapon, Supacha Benjamin, Theeraphan Chumroenphat, and Piyaporn Saensouk. "In Vitro Propagation, Evaluation of Antioxidant Activities, and Phytochemical Profiling of Wild and In Vitro-Cultured Plants of Curcuma larsenii Maknoi & Jenjitikul—A Rare Plant Species in Thailand." Horticulturae 10, no. 11 (2024): 1181. http://dx.doi.org/10.3390/horticulturae10111181.

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Curcuma larsenii Maknoi & Jenjitikul is a member of the Zingiberaceae family, possessing significant pharmacological potential, although it has become endangered through the abuse of resources. This research article delineates the findings of the in vitro propagation, transplantation, and phytochemical profiles of C. larsenii, a rare plant species in Thailand. Microshoots measuring 1 cm in length were used as explants for the induction of shoots and roots in both solid and liquid Murashige and Skoog medium, incorporating various concentrations of cytokinins (6-benzylamino-purine (BA), 6-fu

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Sadowska-Krępa, Ewa, Barbara Kłapcińska, Anna Nowara, et al. "High-dose testosterone supplementation disturbs liver pro-oxidant/antioxidant balance and function in adolescent male Wistar rats undergoing moderate-intensity endurance training." PeerJ 8 (November 19, 2020): e10228. http://dx.doi.org/10.7717/peerj.10228.

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In some countries, anabolic-androgenic steroid abuse is rampant among adolescent boys and young men, including some of those seeking physical fitness and/or pleasing appearance through various exercise types. This tactic carries the risk of severe harmful health effects, including liver injury. Most anabolic-androgenic steroid stacking protocols employed are based on the use of the ‘prototypic’ anabolic-androgenic steroid testosterone and/or its esters. There is a vast body of data on the effects of anabolic-androgenic steroids’ abuse combined with physical exercise training on the liver antio

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Kika, V., and O. Makarenko. "Development of oxidative stress in laboratory rats with alcohol intoxication." Visnyk of Lviv University. Biological series, no. 87 (November 11, 2022): 130–38. http://dx.doi.org/10.30970/vlubs.2022.87.11.

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Introduction: the imbalance between the formation of reactive oxygen species (ROS) and the ability of cells to neutralize them is characterized as oxidative stress and occurs in almost any pathological condition. Reactions to convert ethanol to acetic acid are accompanied by an increase in ROS production. Given the prevalence of alcohol abuse and the contribution of oxidative stress to the development of pathological conditions, we formulated the aim of our work: to assess the impact of chronic alcohol intoxication on the development of oxidative stress in the mucous membranes of the digestive

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Tia, Ayu Novitasari, Taufikurohmah Titik, and Soepardjo Djodjok. "The Effect of Nanogold-Nanosilver for Immune Enhancement of Drug Abuse Victims in Areas Affected by COVID-19." International Journal of Current Science Research and Review 04, no. 01 (2021): 39. https://doi.org/10.47191/ijcsrr/V4-i1-06.

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Abstract : The development of confirmed cases of COVID-19 in Indonesia is increasing, but until now there is no specific drug to prevent the virus. Therefore, it is necessary to do a research to produce a drug that can prevent this virus. Efforts to prevent the spread of COVID-19 and to avoid contracting the virus can be done by strengthening the immune system. Currently, the development of nanogold and nanosilver utilization occurs very rapidly, especially in the health sector due to its antibacterial and antioxidant properties. In this research, nanogold-nanosilver was presented in the form

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Liang, Yan, Samantha M. Yeligar, and Lou Ann S. Brown. "Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome." Scientific World Journal 2012 (2012): 1–9. http://dx.doi.org/10.1100/2012/740308.

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Chronic alcohol ingestion increases the risk of developing acute respiratory distress syndrome (ARDS), a severe form of acute lung injury, characterized by alveolar epithelial and endothelial barrier disruption and intense inflammation. Alcohol abuse is also associated with a higher incidence of sepsis or pneumonia resulting in a higher rate of admittance to intensive care, longer inpatient stays, higher healthcare costs, and a 2–4 times greater mortality rate. Chronic alcohol ingestion induced severe oxidative stress associated with increased ROS generation, depletion of the critical antioxid

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Arazi, Hamid, Siavash Rahmati, and Hosein Ghafoori. "The interaction effects of resistance training and sustanon abuse on liver antioxidant activities and serum enzymes in male rats." Interventional Medicine and Applied Science 9, no. 3 (2017): 178–83. http://dx.doi.org/10.1556/1646.9.2017.29.

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Sharma, Anjali, Sharad Wakode, Faizana Fayaz, Shaik Khasimbi, Faheem H. Pottoo, and Avneet Kaur. "An Overview of Piperazine Scaffold as Promising Nucleus for Different Therapeutic Targets." Current Pharmaceutical Design 26, no. 35 (2020): 4373–85. http://dx.doi.org/10.2174/1381612826666200417154810.

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Piperazine scaffolds are a group of heterocyclic atoms having pharmacological values and showing significant results in pharmaceutical chemistry. Piperazine has a flexible core structure for the design and synthesis of new bioactive compounds. These flexible heterogenous compounds exhibit various biological roles, primarily anticancer, antioxidant, cognition enhancers, antimicrobial, antibacterial, antiviral, antifungal, antiinflammatory, anti-HIV-1 inhibitors, antidiabetic, antimalarial, antidepressant, antianxiety and anticonvulsant activities, etc. In the past few years, researchers focused

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Verma, Shiv Bhushan, Chitranjan Kumar, and Raghvendra Pratap Narayan. "Organic inputs with reduced chemical fertilizers improve yield, antioxidant components, and defense mechanisms in Tomato (var. Pusa Sheetal)." BIO Web of Conferences 110 (2024): 01011. http://dx.doi.org/10.1051/bioconf/202411001011.

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Chemical fertilizers are widely used to meet the nutritional needs of crops and increase yields; but, due to their high cost and abuse, certain adverse effects are causing the soil to deteriorate. A decline in soil organic carbon is being addressed through the use of vermicompost and farmyard manure as organic amendments, potentially reducing chemical fertilizer usage and ensuring sustainable crop nutrient supply. A study utilizing cattle farmyard manure and vermicompost, along with reduced chemical fertilizers, demonstrated that organic inputs significantly enhance tomato growth, physiology,

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Han, Youngji, Seonggeun Zee, and Kyung-Hyun Cho. "Beeswax Alcohol and Fermented Black Rice Bran Synergistically Ameliorated Hepatic Injury and Dyslipidemia to Exert Antioxidant and Anti-Inflammatory Activity in Ethanol-Supplemented Zebrafish." Biomolecules 13, no. 1 (2023): 136. http://dx.doi.org/10.3390/biom13010136.

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Alcohol abuse, a global health problem, is closely associated with many pathological processes, such as dyslipidemia and cardiovascular disease. In particular, excessive alcohol consumption promotes dyslipidemia and liver damage, such as hepatic steatosis, fibrosis, and cirrhosis. Beeswax alcohol (BWA) is a natural product used for its antioxidant properties that has not been evaluated for its efficacy in alcohol-induced liver injury. In the present study, zebrafish were exposed to 1% ethanol with supplementation of 10% fermented black rice bran (BRB-F), 10% BWA, or 10% mixtures of BWA+BRB-F (

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Charles, Ifedi I., Nwafor C. Charles, Ihezuruoha C. Salome, Ovie F. O, Ifedi O. Blessing, and Igwedibia C. Paul. "The Effects of Mkpuru Mmiri Consumption on Cognitive Performance and Brain Histology in an Animal Study." Journal of Pharmaceutical Research International 36, no. 6 (2024): 43–53. http://dx.doi.org/10.9734/jpri/2024/v36i67521.

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Mkpuru mmiri, popularly known as ice or methamphetamine (METH) is one of the illegal substances that young people in Nigeria abuse most frequently. The purpose of the study is to determine how methamphetamine affects the cognitive-motor behavior of Wistar rats. In the study, twenty-five Wistar rats weighing between 117 and 138 grams were split into five groups: group A had only rat feed and water, group B - D received doses of METH ranging from 5 mg/kg to 20 mg/kg, and group E received a dose of 5 mg/kg of diazepam. Neurobehavioral tools such as the navigator maze test, elevated plus maze and

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El-Kersh, Dina M., Rania F. Abou El-Ezz, Eman Ramadan, and Reham F. El-kased. "In vitro and in vivo burn healing study of standardized propolis: Unveiling its antibacterial, antioxidant and anti-inflammatory actions in relation to its phytochemical profiling." PLOS ONE 19, no. 5 (2024): e0302795. http://dx.doi.org/10.1371/journal.pone.0302795.

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Background Natural propolis has been used since decades owing to its broad-spectrum activities. Burn injuries are a global health problem with negative impacts on communities. Bacterial infections usually accompany burns, which demand implementation of antibiotics. Antibiotics abuse led to emergence of microbial drug resistance resulting in poor treatment outcomes. In such instances, the promising alternative would be natural antimicrobials such as propolis. Objective Full chemical profiling of propolis and evaluation of in vitro antibacterial, antioxidant and anti-inflammatory activities as w

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Oreščanin-Dušić, Zorana, Nikola Tatalović, Teodora Vidonja-Uzelac, et al. "The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/5969486.

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Ibogaine is an indole alkaloid originally extracted from the root bark of the African rainforest shrub Tabernanthe iboga. It has been explored as a treatment for substance abuse because it interrupts drug addiction and relieves withdrawal symptoms. However, it has been shown that ibogaine treatment leads to a sharp and transient fall in cellular ATP level followed by an increase of cellular respiration and ROS production. Since contractile tissues are sensitive to changes in the levels of ATP and ROS, here we investigated an ibogaine-mediated link between altered redox homeostasis and uterine

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Mykytenko, A. O., O. Y. Akimov, and K. S. Neporada. "Influence of lipopolysaccharide on the development of oxidative-nitrosative stress in the liver of rats under conditions of chronic alcohol intoxication." Fiziolohichnyĭ zhurnal 68, no. 2 (2022): 29–35. http://dx.doi.org/10.15407/fz68.02.029.

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Alcohol abuse is a common phenomenon among the countries of the European continent. One of the first organs suffering from alcohol-induced damage is the liver. Activation of Kupffer cells, as part of the mononuclear phagocyte system, plays a significant role in the development of oxidative-nitrosative damage of the liver. Systemic inflammatory response affects the polarization of macrophages throughout the body and may affect the development of alcohol damage of hepatocytes. The aim of this work is to study the effect of in vivo stimulation by S. typhi bacterial lipopolysaccharide on the devel

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Mohammadnejad, Leila, and Kambiz Soltaninejad. "Tramadol-Induced Organ Toxicity via Oxidative Stress : A Review Study." International Journal of Medical Toxicology and Forensic Medicine 12, no. 1 (2022): 35430. http://dx.doi.org/10.32598/ijmtfm.v12i1.35430.

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Background: Tramadol (TR) is a synthetic opioid-like centrally acting analgesic used for moderate to severe pain management in various diseases. Numerous investigations have supported the association between tramadol use and increased levels of oxygen-free radicals. Mass production of reactive oxygen species produces secondary toxic compounds. This could damage the internal components of the cell and ultimately causes organ damage. There exists a growing trend of tramadol abuse and the increasing reports of poisoning, abuse, and mortality due to this drug. Thus, the present study aimed to revi

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Gaydos, Jeanette, Alicia McNally, Ruixin Guo, R. William Vandivier, Philip L. Simonian, and Ellen L. Burnham. "Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 310, no. 6 (2016): L507—L518. http://dx.doi.org/10.1152/ajplung.00242.2015.

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Alcohol use disorders (AUDs) and tobacco smoking are associated with an increased predisposition for community-acquired pneumonia and the acute respiratory distress syndrome. Mechanisms are incompletely established but may include alterations in response to pathogens by immune cells, including alveolar macrophages (AMs) and peripheral blood mononuclear cells (PBMCs). We sought to determine the relationship of AUDs and smoking to expression of IFNγ, IL-1β, IL-6, and TNFα by AMs and PBMCs from human subjects after stimulation with lipopolysaccharide (LPS) or lipoteichoic acid (LTA). AMs and PBMC

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Fu, Min, Hui Liu, Wenbo Yang, et al. "Virtual Cold Chain Method with Comprehensive Evaluation to Reveal the Effects of Temperature Abuse on Blueberry Quality." Foods 13, no. 23 (2024): 3731. http://dx.doi.org/10.3390/foods13233731.

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Blueberry is one of the most perishable fruits, and the postharvest supply chain environment temperature has great effects on fruit quality. In order to determine the critical steps referring to non-optimal conditions and the key quality indexes in response to temperature along the cold chain, 15 time–temperature scenarios were conducted simultaneously for the storage of blueberry fruits and 17 quality attributes were determined. The results indicated that different cold chain steps under abusing temperatures significantly affected blueberry qualities. Based on the comprehensive evaluation ana

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Vasarri, Marzia, Lucia De Marchi, Carlo Pretti, Emanuela Barletta, and Donatella Degl’Innocenti. "Antioxidant and Anti-Inflammatory Properties of Four Native Mediterranean Seagrasses: A Review of Bioactive Potential and Ecological Context." Marine Drugs 23, no. 5 (2025): 206. https://doi.org/10.3390/md23050206.

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This review provides current knowledge of the potential benefits of native Mediterranean seagrasses for human health, specifically focusing on their anti-inflammatory and antioxidant properties. The four main species examined—Posidonia oceanica, Cymodocea nodosa, Zostera marina, and Zostera noltii—are integral components of marine ecosystems, providing essential habitats and supporting biodiversity. Recent studies highlight their rich bioactive compounds that show significant therapeutic potential against oxidative stress and chronic inflammation, which are prevalent in various health disorder

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Downey, Luke A., and Jennifer M. Loftis. "Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine." European Journal of Pharmacology 727 (March 2014): 125–29. http://dx.doi.org/10.1016/j.ejphar.2014.01.032.

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Hari Shanker Sharma, Per-Ove Sjoquist, and Syed F. Ali. "Drugs of Abuse-Induced Hyperthermia, Blood-Brain Barrier Dysfunction and Neurotoxicity: Neuroprotective Effects of a New Antioxidant Compound H-290/51." Current Pharmaceutical Design 13, no. 18 (2007): 1903–23. http://dx.doi.org/10.2174/138161207780858375.

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Aminu, Imam, Kudirat Funmi Lambe Oladeji, Abdulwasiu Taiwo Lawal, et al. "Repeated benzodiazepines ingestions affected behavioral and neurochemical profiles, with mild effect on histological integrities: modulatory efficacy of Nigella sativa oil." üha 11, no. 2 (2024): 29–37. http://dx.doi.org/10.32739/uha.jnbs.11.1538964.

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Background: Benzodiazepines (BZDs) are a class of depressant drugs that have enjoyed widespread use in conventional clinical management of anxiety-related conditions such as panic disorders that require therapeutic central relaxation and sedation. Meanwhile, prolonged administration of benzodiazepines even at low doses has however been linked to variety of undesirable effects such as discontinuation relapse with the associated risk of abuse and dependency. Aim: This study investigated the behavioral, histological and biochemical outcomes of long-term low dose diazepam use and explored the pote

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Hussain, Usman, Nikit Venishetty, Marwan Alkassis, and Omer Raheem. "The Clinical Management of Leukocytospermia in Male Infertility: A Narrative Review." Uro 4, no. 2 (2024): 36–49. http://dx.doi.org/10.3390/uro4020004.

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A major global health concern, male infertility affects 8–12% of couples globally. Leukocytospermia is a complicated illness that is distinguished from other reasons causing male infertility by having high white blood cell counts in semen. The complex mechanisms behind leukocytospermia’s effects on sperm function and fertility are examined in this review. Leukocytospermia induces oxidative stress and reactive oxygen species (ROS) that impair DNA integrity, mitochondrial function, cytoplasmic extrusion, and sperm quality overall. Leukocytospermia is exacerbated by non-infectious factors, such a

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Soltaninejad, Masoud, Mehran Ilaghi, Reza Saboori Amleshi, and Mohammad Shabani. "Quercetin as a Complementary Therapy in Substance Use Disorder: A Narrative Review." Journal of Kerman University of Medical Sciences 32 (March 2, 2025): 3816. https://doi.org/10.34172/jkmu.3816.

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Substance use disorder (SUD) is a pervasive public health concern characterized by compulsive drug use despite adverse consequences. SUD treatment strategies aim to help addicts stop obsessively seeking and consuming drugs. These approaches could be provided in a variety of venues, utilizing a range of behavioral and pharmacological techniques. Emerging research explores alternative treatments for SUD, including the use of medicinal plants. Quercetin, a natural flavonoid present in various fruits and vegetables, exhibits promising pharmacological properties. This naturally occurring pharmaceut

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Bajpai, Vivek K., Ashutosh Bahuguna, Vishal Kumar, et al. "Cellular antioxidant potential and inhibition of foodborne pathogens by a sesquiterpene ilimaquinone in cold storaged ground chicken and under temperature-abuse condition." Food Chemistry 373 (March 2022): 131392. http://dx.doi.org/10.1016/j.foodchem.2021.131392.

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Li, Jiahe, Jiacheng Ma, Michael J. Lacagnina, et al. "Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling." Anesthesiology 132, no. 2 (2020): 343–56. http://dx.doi.org/10.1097/aln.0000000000003077.

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Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Available treatments for neuropathic pain have modest efficacy and significant adverse effects, including abuse potential. Because oxidative stress is a key mechanistic node for neuropathic pain, the authors focused on the master regulator of the antioxidant response—nuclear factor erythroid 2-related factor 2 (NFE2L2; Nrf2)—as an alternative target for neuropathic pain. The authors tested whether dimethyl fumarate (U.S. Food and Drug Administration-approved treatment for multi

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Ruiz-Yance, Iris, Junior Siguas, Brandy Bardales, et al. "Potential Involvement of Oxidative Stress, Apoptosis and Proinflammation in Ipconazole-Induced Cytotoxicity in Human Endothelial-like Cells." Toxics 11, no. 10 (2023): 839. http://dx.doi.org/10.3390/toxics11100839.

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Triazole fungicides are widely used in the world, mainly in agriculture, but their abuse and possible toxic effects are being reported in some in vivo and in vitro studies that have demonstrated their danger to human health. This in vitro study evaluated the cytotoxicity, oxidative stress and proinflammation of EA.hy926 endothelial cells in response to ipconazole exposure. Using the MTT assay, ipconazole was found to produce a dose-dependent reduction (*** p < 0.001; concentrations of 20, 50 and 100 µM) of cell viability in EA.hy926 with an IC50 of 29 µM. Also, ipconazole induced a signific

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Mehta, Shashi Dhar, Umesh Kumar, Anil Kumar Mavi, Vinod Kumar, Suhel Parvez, and Suhasini Bhatnagar. "Effect of Allium Sativum on the Alcohol Induced Neuropathic Pain in Wistar Rats." Defence Life Science Journal 7, no. 4 (2022): 248–56. http://dx.doi.org/10.14429/dlsj.7.17774.

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Neuropathic pain is a severe pain condition associated with pathological changes which have deleterious effects like dysfunction of the brain. Alcohol abuse is known to be the most common reason at present for developing neuropathic pain. Alcohol-induced neuropathic pain can be assessed by ache studies such as hyperalgesia and allodynia which characterizes the response severity of induced pain. In the current research, we used the Allium Sativum (Garlic) bulb extract to study the effect on alcohol-administered rodents. The behavioral and biochemical studies have been done. It has been reported

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Kim, Dae Yoon, Seung Cheol Shin, Gab Jung Kim, et al. "The Beneficial Effects of Ethanol Extract of the Microalga Phaeodactylum tricornutum in Alcoholic Liver Disease." International Journal of Molecular Sciences 26, no. 8 (2025): 3851. https://doi.org/10.3390/ijms26083851.

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Alcoholic liver disease (ALD) is a condition resulting from liver damage linked to excessive drinking over a brief duration. It poses a significant public health challenge globally, with its prevalence and morbidity rising annually due to escalating rates of alcohol abuse, which adversely affect human health. Phaeodactylum tricornutum (PT), a diatom species of microalgae, is reported to possess active components that provide anti-inflammatory and antioxidant benefits. This study aimed to investigate the preventive and therapeutic effects of PT extract on ALD. To address our purpose, we used et

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Huang, Jian, Jiuyang Ding, Zhuo Wang, et al. "Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway." Oxidative Medicine and Cellular Longevity 2022 (March 28, 2022): 1–23. http://dx.doi.org/10.1155/2022/8400876.

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Chronic and long-term methamphetamine (METH) abuse is bound to cause damages to multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS), a type of flavonoid and one of the main active ingredients of the traditional Chinese medicine Epimedium, exhibits a variety of biological and pharmacological properties such as anti-inflammatory, antioxidant, and anticancer activities. However, whether ICS could protect against METH-induced neurotoxicity remains unknown. Based on a chronic METH abuse mouse model, we detected the neurotoxicity after METH exposure and deter

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