Relevant bibliographies by topics / Antioxidant and antimutagenic activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Antioxidant and antimutagenic activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Antioxidant and antimutagenic activity"

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Gautam, Vandana, Sukhmeen Kohli, Saroj Arora, Renu Bhardwaj, Mohsin Kazi, Ajaz Ahmad, Mohammad Raish, Majid Ganaie, and Parvaiz Ahmad. "Antioxidant and Antimutagenic Activities of Different Fractions from the Leaves of Rhododendron arboreum Sm. and Their GC-MS Profiling." Molecules 23, no. 9 (September 3, 2018): 2239. http://dx.doi.org/10.3390/molecules23092239.

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In this era of urbanization and environmental pollution, antioxidants and antimutagens derived from plants are promising safeguards for human health. In the current investigation, we analyzed the antioxidant and antimutagenic effects of the hexane, chloroform, and ethyl acetate fractions of Rhododendron arboreum Sm. leaves and determined their chemical composition. The different fractions inhibited lipid peroxidation, repressed the production of nitric oxide radicals, and prevented deoxyribose degradation. The antimutagenic activity of the leaf fractions was analyzed against 4-nitro-O-phenylenediamine, sodium azide and 2-aminofluorene mutagens in two test strains (TA-98 and TA-100) of Salmonella typhimurium. The experiment was conducted using pre- and co-incubation modes. The best results were obtained in the pre-incubation mode, and against indirect acting mutagen. The presence of a number of bioactive constituents was confirmed in the different fractions by GC-MS analysis. The study reveals the strong antioxidant and antimutagenic activity of R. arboreum leaves. We propose that those activities of R. arboreum might correspond to the combined effect of the phytochemicals identified by GC-MS analysis. To the best of our knowledge, this is the first report on the antimutagenic activity of R. arboreum leaves.
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Bunkova, R., I. Marova, Z. Pokorna, and A. Lojek. "Analysis of Plant Extracts Antimutagenicity Using the Ames Test and the Cytogenetic Analysis of Peripheral Blood Lymphocytes." Food Science and Technology International 11, no. 2 (April 2005): 107–12. http://dx.doi.org/10.1177/1082013205052764.

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This work was focused on comparison of antimutagenic effect of selected plant extracts (carrot, paprika, tomato, spinach, onion, kiwi and green tea) analysed by two independent tests of genotoxicity: i) the Ames test with Salmonella typhimurium TA98 and ii) cytogenetic analysis of peripheral blood lymphocytes (CAPL). Both methods were proved without and/or with metabolic activation. Samples were allowed to be positive antimutagens based on their ability to inhibit the mutagenic effects of standard mutagens. High positive results (more than 60% of inhibition of mutagenic effect) were obtained with extract from green tea. Extracts from paprika, carrot and spinach as well as solutions of standard alltrans-carotene and some standard flavonoids showed antimutagenic (40-60% of inhibition) or weakly antimutagenic (20-40% of inhibition) effects. Positive antimutagenic effects of extracts from spinach and green tea were determined using CAPL method too. Further, the comparison of antimutagenic activity and antioxidant capacity of tested samples analysed using TRAP (total radical-trapping antioxidant parameter) method was proved. Extract from green tea showed the highest antioxidant as well as antimutagenic capacity, but no correlation was found between these parameters in all tested extracts.
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Zahin, Maryam, Farrukh Aqil, Fohad Mabood Husain, and Iqbal Ahmad. "Antioxidant Capacity and Antimutagenic Potential ofMurraya koenigii." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/263509.

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It is well known that the intake of antioxidants with increased consumption of fruits and vegetables and medicinal herbs contributes towards reduced risk of certain diseases including cancers. This study aims to evaluate the broad-spectrum antioxidant and antimutagenic activities as well as to elucidate phytochemical profile of an Indian medicinal plantMurraya koenigii(curry) leaves. Leaves of the plant were successively fractionated in various organic solvents. Benzene fraction demonstrated the highest phenolic content followed by petroleum ether. The benzene fraction showed maximum antioxidant activity in all tested assays, namely, phosphomolybdenum, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, ferric reducing antioxidant power (FRAP) and cupric reducing antioxidant capacity (CUPRAC) assays. Based on the promising broad-spectrum antioxidant activity, benzene fraction was further evaluated for antimutagenic activity and showed a dose-dependent antimutagenic response in AmesSalmonellamutagenicity assay. It inhibited 72–86% mutagenicity induced by sodium azide, methyl methanesulfonate, benzo(a)pyrene, and 2-aminoflourene at the maximum tested concentration (100 μg/mL) inSalmonella typhimuriumtester strains. At least 21 compounds were detected by GC/MS. The findings clearly demonstrated that phenolic-rich benzene fraction has promising broad-spectrum antioxidant and antimutagenic property and needs further evaluation to exploit its therapeutic potential.
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Vaidya, Santosh Kumar, Dharmesh K. Golwala, and Darpini S. Patel. "Antioxidant and Antimutagenic (Anticlastogenic) Effect of Solanum xanthocarpum Seed Extracts." International Journal of Pharmaceutical Sciences and Nanotechnology 13, no. 4 (July 12, 2020): 5005–10. http://dx.doi.org/10.37285/ijpsn.2020.13.4.6.

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The aim of the present study was to investigate the in-vitro antioxidant and in-vivo Antimutagenic properties of Solanum xanthocarpum seed extracts the preliminary qualitative phytochemical screening was to reveal presence of polyphenols, flavonoids, glycoside, alkaloids, carbo-hydrates, and reducing sugar etc. Based preliminary qualitative phytochemical screening, Quantitative estimation of polyphenols was performed, quantitative estimation alcoholic extract found significant amounts of polyphenols as compare to aqueous extract. In-vitro antioxidants was performed by two method DDPH and superoxide radical scavenging method, the alcoholic extract shows significant antioxidant properties as compare to aqueous extract, based on polyphenols and antioxidant properties alcoholic extracts was used for the antimutagenic (clastogenic) test. Alcoholic extract produced significant result in antimutagenic activity.
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Anish, Anusha, Sherena Padinjarevattom Abdulkadir, Annamala Panthapulakkil Theru, and Mukkadan Joseph Kurian. "Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii." Asian Pacific Journal of Cancer Biology 5, no. 4 (December 7, 2020): 147–52. http://dx.doi.org/10.31557/apjcb.2020.5.4.147-152.

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Introduction: Edible and medicinal plants contain active principles that can act as antimutagens, and hence their intake may be useful for human cancer prevention. Green leafy vegetables are important sources of carotenoids which possess antioxidant, anti-inflammatory and antimutagenic properties. Objective: To study the antimutagenic activity of oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves). Methods: Oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) were investigated for antimutagenic activity in vitro by Ames test using Salmonella typhimurium strains TA 98 and TA 1535. Mutagens used were, nitro-o- phenylenediamine (NPD) (20μg/plate) and N-methyl- N-nitro-N-nitrosoguanidine (MNNG) (1μg/ plate). Results: The results revealed that oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) administered at doses of 1.0 mg, 2.5 mg and 5 mg per plate significantly inhibited mutagenicity induced by NPD and MNNG.Conclusion: These findings suggest that oxycarotenoid- rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) have antimutagenic properties.
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Ramadan, Doaa T., Mohamed A. M. Ali, Shaymaa M. Yahya, and Wael M. El-Sayed. "Correlation between Antioxidant/Antimutagenic and Antiproliferative Activity of Some Phytochemicals." Anti-Cancer Agents in Medicinal Chemistry 19, no. 12 (December 2, 2019): 1481–90. http://dx.doi.org/10.2174/1871520619666190528091648.

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Background: Chemotherapeutic drugs have high toxicity associated with undesirable side-effects. Now, natural products are the most important anti-cancer agents because of their low toxicity and potential effectiveness. Methods: The half maximal inhibitory concentration (IC50) of amygdalin, naringenin and ellagic acid against breast, colon, and liver cell lines was estimated. The antimutagenic, free radical-, superoxide radical-, and hydroxyl radical- scavenging activities of these phytochemicals were measured. The expression of p53, bid, bax, bcl2, and caspases 9, 3, and 7 was measured by quantitative real-time polymerase chain reaction (qRT-PCR) in breast and liver cells. In addition, the active Caspase 3 protein was estimated in liver cells. Results: Ellagic acid showed the highest antioxidant and antiproliferative activities. Amygdalin and naringenin with low and moderate antioxidant profiles showed a corresponding low and moderate cytotoxicity against cancer cell lines, respectively. Naringenin and ellagic acid had a significant antimutagenic activity which was detected by the Salmonella test. Ellagic acid offered a much better antimutagenic activity than naringenin. The apoptotic pathway evoked by ellagic acid in HepG2 and MCF-7 cells was investigated. The results showed that a caspase-dependent and a caspase-independent apoptosis occurred in MCF-7 and HepG2, respectively. Conclusion: The antimutagenic/antioxidant properties are well correlated with the antiproliferative activity of the phytochemicals investigated. This study proved that some easy, quick and cheap assays could predict the antiproliferative activity of many nutraceuticals. Finally, this platform could help in the discovery of new anticancer agents where hundreds of compounds are investigated in the pipeline of drug discovery.
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KOGAN, G., Y. SKORIK, I. ITANOVA, L. KRIKOVA, Z. URAKOVA, C. GOMES, Y. YATLUK, and J. KRAJOVI. "Antioxidant and antimutagenic activity of -(2-carboxyethyl)chitosan." Toxicology and Applied Pharmacology 201, no. 3 (December 15, 2004): 303–10. http://dx.doi.org/10.1016/j.taap.2004.05.009.

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Spada, Patrícia D. S., Gabrielle Gianna Nunes de Souza, Giovana Vera Bortolini, João A. P. Henriques, and Mirian Salvador. "Antioxidant, Mutagenic, and Antimutagenic Activity of Frozen Fruits." Journal of Medicinal Food 11, no. 1 (March 2008): 144–51. http://dx.doi.org/10.1089/jmf.2007.598.

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Del-Toro-Sánchez, Carmen Lizette, Nereyda Bautista-Bautista, José Luis Blasco-Cabal, Marisela Gonzalez-Ávila, Melesio Gutiérrez-Lomelí, and Myriam Arriaga-Alba. "Antimutagenicity of Methanolic Extracts fromAnemopsis californicain Relation to Their Antioxidant Activity." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/273878.

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Anemopsis californicahas been used empirically to treat infectious diseases. However, there are no antimutagenic evaluation reports on this plant. The present study evaluated the antioxidant activity in relation to the mutagenic and antimutagenic activity properties of leaf (LME) and stem (SME) methanolic extracts ofA. californicacollected in the central Mexican state of Querétaro. Antioxidant properties and total phenols of extracts were evaluated using DPPH (1,1-diphenyl-2-picrylhydrazyl) and Folin-Ciocalteu methods, respectively. Mutagenicity was evaluated using the Ames test employingSalmonella entericaserovar Typhimurium strains (TA98, TA100, and TA102), with and without an aroclor 1254 (S9 mixture). Antimutagenesis was performed against mutations induced on the Ames test with MNNG, 2AA, or 4NQO. SME presented the highest antioxidant capacity and total phenolic content. None of the extracts exhibited mutagenicity in the Ames test. The extracts produced a significant reduction in 2AA-induced mutations inS. typhimuriumTA98. In both extracts, mutagenesis induced by 4NQO or methyl-N′-nitro-N-nitrosoguanidine (MNNG) was reduced only if the exposure of strains was <10 μg/Petri dish.A. californcaantioxidant properties and its capacity to reduce point mutations render it suitable to enhance medical cancer treatments. The significant effect against antimutagenic 2AA suggests that their consumption would provide protection against carcinogenic polycyclic aromatic compounds.
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Halavach, Т. M., E. I. Tarun, N. V. Dudchik, R. V. Romanovich, I. A. Bubra, and V. P. Kurchenko. "Description of biologically active protein hydrolysates of whey and colostrum." Proceedings of the National Academy of Sciences of Belarus, Biological Series 63, no. 4 (October 30, 2018): 409–18. http://dx.doi.org/10.29235/1029-8940-2018-63-4-409-418.

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Antioxidant, antimutagenic and antigenic properties of partial hydrolysates of whey and colostrum obtained using bacterial endopeptidase (alcalase) have been investigated. It was found that the depth of proteolysis, qualitative and quantitative composition of protein component of samples determined the level of their antiradical and antimutagenic activity. According to SDS-electrophoresis whey hydrolysate contains cleaved allergen proteins, whereas colostrum hydrolysate possesses a high molecular weight fraction (>10 kDa) of partially digested immunoglobulins. Proteolysis of β-lactoglobulin, which has a high allergenic potential, is confirmed by results of immunoprecipitation reaction. In accordance with the ORAC method antioxidant action of hydrolysed whey and colostrum increased by 2.8 and 5.0 times, respectively. Antimutagenic effect for whey hydrolysate was 15.7–49.2 % when tested on the strain Salmonella typhimurium TA 98 and 18.8–52.1 % for strain TA 100. It exceeded values of colostrum hydrolysate. Samples of whey and colostrum hypoallergenic hydrolysates with confirmed antioxidant and antimutagenic properties have been obtained.
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Dissertations / Theses on the topic "Antioxidant and antimutagenic activity"

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Barošová, Michaela. "Sledování antioxidantů v sušeném ovoci." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216231.

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Presented diploma work is focused on study of antioxidants in different kinds of dried fruits. Analyses of ascorbate, tocopherols, carotenoids and flavonoids were performed using RP-HPLC with spectrophotometric detection. Analysis of dried fruits showed high level of vitamins and phenolocs mainly in berries. High level of carotenoids was observed in dried apricots and plums. Further, antioxidant activity of dried fruit extracts was tested by ABTS method. High antioxidant activity was found mainly in dried apples, cranberries and blueberries. The biological test with yeast Sascharomyces cerevisiae D7 was used for the analysis of antimutagenic efects of dried fruits. High antimutagenic activity exhibited dried cranberries and blueberries. Most of tested dried fruits with high antimutagenic effect exhibited also high antioxidant activity as well as high content of some antioxidants. No direct correlation was found among these parameters. Last part of this work was focused on study of influence of drying on antioxidant content in two types of apples. Drying at mild controlled conditions exhibited no significant negative effect on active substance content; in some samples their concentration was observed.
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Tomková, Martina. "Obsah antioxidačních látek ve vybraných druzích ovocných a bylinných čajů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216228.

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This diploma project deals with antioxidant and antimutagenic properties of selected herbal and fruit teas commonly used in Czech population. Influence of different tea packaging (bag teas and loose leaf teas) on bioactive compound content was compared. Further, effect of long-term storage in common household conditions was studied. Antioxidant properties of teas were characterized using some group parameters - total antioxidant activity ("Randox Total Antioxidant Status Kit"), total phenolics and total flavonoids - as well as some individual representatives of low molecular weight antioxidants. Higher antixidant content was found in herbal teas than in fruit teas. Comparing bag teas with loose leaf teas higher antioxidant activity was shown in loose leaf teas. Individual antioxidants were analyzed using HPLC method with spectrophotometric detection and verified by on-line LC/MS. IN all tea samples catechins - catechin, epicatechin, epicatechin gallate and other flavonoids - rutin, morin, quercetin, kaempferol, myricetin and luteolin were determined. In most of teas high level of catechin and rutin was detected. The highest level of flavonoids was determined in herbal poured teas. Ascorbic acid content was also determined by HPLC method. Higher vitamine C level was found in most of fruit teas and in rose hip tea. Antimutagenicity of tea extracts was tested by in vitro test using Saccharomyces cerevisiae D7 yeast. High antimutagenic activity showed mainly nettle tea, tutsan tea and most of fruit teas. During long-term storage (1 year, 20°C, darkness) a significant decrease of all analyzed antioxidant parameters was followed. Higher lost of antioxidants was found in fruit teas when compared with the herbal ones.
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Pedreschi, Romina Paola. "Fractionation of phenolic compounds from a purple corn extract and evaluation of antioxidant and antimutagenic activities." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2343.

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Qualitative and quantitative analysis of anthocyanins and other phenolic compounds from a purple corn extract was performed. The purple corn extract had cyanidin-3-glucoside, pelargonidin-3-glucoside, peonidin-3-glucoside and its respective acylated anthocyanin-glucosides. Cyadinin-3glucoside was the main constituent (44.4 ?? 4.7%) followed by the acylated cyanidin-3-glucoside (26.9 ?? 8.0%). Other phenolic compounds present in the purple corn corresponded to protocatechuic acid, vanillic acid, and p-coumaric acid. In addition, quercetin derivatives, a hesperitin derivative and pcoumaric and ferulic acid derivatives were found. Fractionation of phenolic compounds yielded two main fractions, an anthocyanin-rich water fraction (WF) and an ethyl acetate fraction (EAF). Evaluation of antimutagenic activity in both fractions revealed higher antimutagenic activity in the ethyl acetate fraction compared to the anthocyanin-rich fraction. On the other hand, antioxidant activity of the anthocyanin-rich fraction was higher compared to the ethyl acetate fraction. Further fractionation of the anthocyanin-rich fraction in a Toyopearl HW40 gel permeation column yielded five sub-fractions which showed no difference in antimutagenic activity except for the water sub-fraction WF-V. All the sub-fractions were active as antimutagens and antioxidants. Further fractionation of the ethyl acetate fraction yielded four sub-fractions that showed to be active as antimutagens and antioxidants. Ethyl acetate sub-fraction EAF-IV was the most active as an antimutagen. HPLC-DAD characterization of that sub-fraction revealed mainly the presence of a quercetin derivative with UV-visible spectral characteristics similar to rutin but with a little longer retention time. The mechanism of antimutagenic action by the phenolic compounds present either in the anthocyanin-rich fraction or the ethyl acetate fraction and sub-fraction EAFIV seems to be a contribution of a direct action on the enzymes involved in the activation of the mutagen and to the scavenging activity of the mutagen nucleophiles, as demonstrated by our assays.
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Richards, Elizabeth Siân. "The antioxidant and antimutagenic activities of Cyclopia spesies and activity-guided fractionation of C. intermedia." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53614.

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Lichnová, Andrea. "Cereálie - aktivní složky, biologické účinky a vybrané aplikace v potravinářství." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2014. http://www.nusl.cz/ntk/nusl-233398.

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The presented doctoral thesis is focused on the study of the biological effects of active compounds found in cereals, on the development of methods of analysis these effects, on the determination of the content of active substances and characterization of the relationship between composition and biological effects of cereals and cereal products. For the analysis several kinds of raw cereal samples (flakes, flour, germ, bran), flavored extruded cereal products and also samples of paddy and husked rice were chosen. To major types of analysed active compounds belong mainly phenolic compounds in the form of glycosides and aglycones, and also saccharides. Group parameters such as total polyphenols, flavonoids and total and reducing saccharides were determined spectrophotometrically, individual phenolics and saccharides were determined by high performance liquid chromatography (HPLC). TEAC, DPPH and CLAMS methods were used to determine the antioxidant activity. Indirect methods of determination of substances with antioxidant effect were used as well. Results of the total antioxidant activity were compared with values of antimutagenic/genotoxic activity obtained by several microbial test systems. Antimutagenic effect was expressed as a percentage of inhibition of effect of standard mutagen and could be considered as a potential preventive effect of cereals to DNA arising primarily by free radicals effect. The highest values of group and individual phenolics, antioxidant and antimutagenic activity were found in germs, bran, in buckwheat products and in coloured and raw rice. In flavoured cereal products addition of chocolate or fruit positively influences content of active phenolic substances as well as sugars, antixidant and antimutagenic activity. In a representative sample of Czech population, questionnairy study was performed to monitor interest in cereals and consumer preferences. The most of consumers consider cereals with chocolate flavour as less healthy than confirmed results of laboratory analyses. In this study some new food products were developed. Several types of model cereal products containing plant (fruit, vegetables) extracts were proposed. Extracts were added to cereals in freeze-dried and encapsulated form. The highest positive effect exhibited addition of local forrest fruit extract. Within preparation of encapsulated extracts several methods of preparing lipid or saccharides particles were also tested. The encapsulation efficiency of the methods and stability and size of particles were analysed. Optimal type of fortified cereal foods could be suggested based on the acquired results. Selected cereals were used as alternative carbon substrates (processed or raw) for the cultivation of microorganisms to produce enriched biomass usable in the feed industry. We can conclude that cereals in raw as well as processed form belong to universal foods and rich sources of biologically active substances. They can be processed by many ways. They can be used for direct consumption, as a part of new products and also undirectly as a substrate for feedstock.
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Fragoso, Variluska. "Alcalóides de Psychotria : fotorregulação e propriedades antioxidantes e antimutagênicas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10958.

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Espécies de Psychotria encontradas no sul do Brasil produzem alcalóides do tipo monoterpeno indólicos, alguns deles com interessantes atividades biológicas e oriundos de novas rotas biossintéticas. P. leiocarpa Cham. & Schlecht. acumula N, b-D-glicopiranosilvincosamida (GPV), o primeiro alcalóide N-glicosilado desta classe a ser descrito. O extrato contendo GPV apresenta atividade analgésica inespecífica e, na planta, sua biossíntese é regulada pelo desenvolvimento e por luz. P. umbellata Vell., por sua vez, produz psicolatina, que apresenta alto potencial farmacológico, pois apresenta atividade analgésica do tipo opióide, ansiolítica e antipsicótica, interagindo com receptores de diversos sistemas de neurotransmissores no sistema nervoso central. Além disso, psicolatina é um eficiente agente redutor de peróxidos e quencher de oxigênio singlet in vitro. Os objetivos do presente trabalho foram estudar a fotorregulação de GPV em plântulas de P. leiocarpa, assim como avaliar os efeitos antioxidantes e antimutagênicos in vivo do extrato foliar bruto de P. umbellata e de psicolatina purificada, utilizando a levedura Saccharomyces cerevisiae. Essas duas últimas substâncias também foram avaliadas quanto à capacidade antioxidante contra o radical hidroxila in vitro. Em ensaios de transição luz-escuro realizados com plântulas assépticas de P. leiocarpa, o acúmulo de GPV mostrou ser responsivo a alterações na condição luminosa de cultivo. O papel negativo do escuro contínuo na biossíntese de GPV foi comprovado pela redução dos níveis deste alcalóide em plântulas cultivadas na luz e transferidas para o escuro. Por outro lado, quando plântulas cultivadas no escuro foram expostas à luz, os níveis de GPVaumentaram, indicando o caráter promotor da luz na produção de GPV. Os efeitos das transições foram mais evidentes em plântulas cultivadas em meio sem sacarose do que em plântulas cultivadas com suprimento exógeno de carboidratos. A biossíntese de GPV é regulada por diferentes faixas de luz. As regiões do azul e do vermelho-extremo aumentaram os teores de GPV. A luz vermelha não afetou de forma significativa o teor de GPV. Os resultados revelam um padrão típico de VLFRs (Very Low Fluence Responses), possivelmente envolvendo ação de PhyA em conjunto com criptocromo.Tanto o extrato bruto foliar de P. umbellata quanto psicolatina apresentaram efeito antioxidante in vivo, reduzindo a inibição do crescimento de Saccharomyces cerevisiae sob estresse oxidativo induzido por peróxido de hidrogênio e paraquat. O extrato e o alcalóide purificado também apresentaram ótima atividade antioxidante in vitro, protegendo contra o ataque do radical hidroxila. Os índices de mutagênese induzida por peróxido de hidrogêncio foram significativamente reduzidos quando as células de S. cerevisiae foram co-cultivadas na presença tanto do extrato quanto de psicolatina.
Species of Psychotria founded in southern Brazil produce a set of novel monoterpene indole alkaloids (MIAs), several of which have interesting biological activities and originate from new metabolic pathways. P. leiocarpa Cham. & Schlecht. accumulates N, b-D-glucopyranosylvincosamide (GPV), the first N-glycosylated MIA described. Leaf extracts containing GPV display nonspecific analgesic activity and, in planta, its biosynthesis is regulated by development and light. P. umbellata Vell., in turn, produces psychollatine which has significant pharmacological potential, since it yields opioid-like analgesic, anxiolytic and antipsychotic activities, interacting with receptors of different neurotransmitter systems in the central nervous system. In addition, psychollatine is an efficient peroxide reducing agent and a singlet oxygen chemical quencher in vitro. This work aimed at studying the photoregulation of GPV in P. leiocarpa seedlings, as well as at investigating the antimutagenic and antioxidant in vivo effects of the crude foliar extract of P. umbellata and purified psychollatine using the yeast Saccharomyces cerevisiae. These last substances were also evaluated for their in vitro antioxidant properties against hydroxyl radicals.In light-dark transition assays with aseptic P. leiocarpa seedlings, GPV accumulation showed to be responsive to changes in light condition. The negative role of continuous dark on GPV biosynthesis was shown by reduction of the alkaloid contents when light growing seedlings were transferred to dark. On the other hand, dark growing seedlings increased GPV contents after light exposure, suggesting a positive light regulation of GPV production. Theseresults were more evident in seedlings cultivated in media without sucrose than in seedlings cultivated with carbohydrate supplementation. GPV biosynthesys is also regulated by different light qualities. Light in the blue and far-red regions increased GPV accumulation, whereas red ligh had no significant influence on GPV yield. These results are in agreement with the profile of VLFRs (Very Low Fluence Responses), mediated by PhyA with coaction of cryptochrome. Both the crude foliar extract of P. umbellata and psychollatine showed in vivo antioxidant effects by reducing the growth inhibition of Saccharomyces cerevisiae under hydrogen peroxide- and paraquat-induced oxidative stress. The extract and the purified alkaloid also showed strong in vitro antioxidant activity against hydroxyl radicals. The levels of hydrogen peroxide-induced mutagenicity were significantly reduced when S. cerevisiae cells were cocultivated with leaf crude extract or psychollatine.
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Dušan, Bugarin. "Antioksidantni, antibakterijski i antimutageni potencijal vrste Myrtus communis L. iz Crne Gore." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2010. http://dx.doi.org/10.2298/NS20100608BUGARIN.

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Ispitivanja hemijskog sastava etarskih ulja iekstrakata izvedena su na vrsti Myrtus communisL. sa pet lokaliteta iz Crne Gore. Pored toga,ispitana je njihova antioksidantna aktivnost urazlicitim in vitro sistemima kako bi se utvrdiouticaj pomenutih ekstrakata i etarskih ulja naneutralizaciju DPPH, NO, OH i 2- radikala, kaoi njihov uticaj na lipidnu peroksidaciju ulipozomima i inhibiciju enzima ksantin-oksidaze.Takode, ispitana je i antibakterijska aktivnostetarskih ulja i ekstrakata ove vrste na 9bakterijskih sojeva, kao i njihov antimutagenipotencijal na bakterijskom soju Escherichia coliIC 202.
In this tessis the chemical analysis of the essential oils and methanolic extracts from five plant samples of Myrtus communis L., collected from different localities in Montenegro, have been investigate. Beside that, their antioxidant activity in differwnt in vitro systems has been study to establish their scavenging potential towards DPPH, NO, OH, and O2- free radicals, as wel as their effects on lipid peroxidation in liposoma and inhibition enzyme XOD. Also, the antibacterial activity of the essential oils and methanolic extract has been study on 9 bacterial strains, as wel as their antimutagenic effects on bacterial strain E. Colli IC202.
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Nataša, Simin. "Sekundarni biomolekuli u vrstama Allium sect. Codonoprasum Rchb. – biološke aktivnosti, fitohemijski i hemotaksonomski aspekti." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=91799&source=NDLTD&language=en.

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Abstract:
U ovoj doktorskoj disertaciji ispitan je hemijski sastav i biološke aktivnostiekstrakata deset  samoniklih  taksona roda  Allium  sect.  Codonoprasum:  A. carinatum subsp. pulchellum,  A. carinatum  subsp. carinatum,  A. fuscum  var. gracile,  A. fuscum  var. fuscum,  A. flavum subsp. flavum,  A. melanantherum,  A. paniculatum  subsp.  marginatum, A. pallens  subsp. tenuiflorum,  A. oleraceum  i  A. rhodopeum, sakupljenih na  27 lokaliteta u Srbiji. Cilj rada bio je da se dobiju podaci o sadržaju biološki aktivnih jedinjenja u ovim, do sada veoma malo ispitanim vrstama roda  Allium, i utvrdi njihova potencijalna lekovita vrednost.Analiza hemijskog sastava obuhvatila je: analizu volatilnih komponenti svežih lukovica primenom headspace GC-MS tehnike, kvalitativnu analizu metanolnih  ekstrakata primenom tečnohromatografskih metoda (LC-DAD-MS i LC-MS-MS),  kvantitativnu analizu odabranih fenolnih jedinjenja LC-MS-MS tehnikom,  određivanje sadržaja ukupnih  monomernih  antocijana  i određivanje aktivnosti aliinaze. Ispitivanja bioloških aktivnosti ekstrakata obuhvatila su: određivanje antioksidantne, antiinflamatorne, antimikrobne, antimutagene i genotoksične aktivnosti, kao i ispitivanje uticaja na rast zdravih i tumorskih ćelija i sposobnosti indukcije ćelijske smrti. Sumiranjem dobijenih rezultata može se zaključiti da ispitivani predstavnici roda Allium  sect.  Codonoprasum  predstavljaju bogate izvore biološki aktivnih jedinjenja sa širokim spektrom bioloških aktivnosti. Sa hemotaksonomskog aspekta značajno je da se dimetil-disulfid  izdvaja kao  najdominantnija  i često jedina  isparljiva komponenta, da ekstrakti većine vrsta  sadrže veliku količinu flavonoida (prvenstveno derivata kvercetina), da se vrste  A. pallens  i  A. oleraceum  izdvajaju od ostalih po tome što ne sadrže rutin  a sadrže  hiperozid,  da je vrsta  A. rhodopeum  siromašna fenolnim jedinjenjima i da su sve vrste, osim vrste  A.  flavum, bogate antocijanima. Aktivnost aliinaze je visoka u svim ispitivanim vrstama. Većina ispitivanih ekstrakata, izuzev ekstrakata vrsta  A. carinatum i A. melanantherum, pokazala je izraženu antioksidantnu aktivnost, dok su ekstrakti vrsta A. flavum, A. rhodopeum, A. oleraceum i A. paniculatum snažni antiinflamatorni agensi. Ekstrakti ispitivanih predstavnika sect.  Codonoprasum nisu pokazali antimikrobnu i antimutagenu aktivnost. Takođe, ovi ekstrakti nisu ispoljili genotoksični efekat na ćelije zdravog tkiva (izuzev slabog genotoksičnog efekta ekstrakta nadzemnih delova  A. flavum), što ukazuje na bezbednost upotrebe vrsta sect. Codonoprasum  kao hrane ili u obliku lekova. Ekstrakti celih biljaka A. paniculatum i A. rhodopeum, kao i ekstrakt nadzemnih delova  A. melanantherum  pokazali su snažnu antiproliferativnu aktivnost sa povoljnim ne-tumor/tumor koeficijentima i indukovali apoptozu u tumorskim ćelijama, iz čega se može zaključiti da imaju visok potencijal primene u antitumorskoj terapiji. 
In the present doctoral thesis the chemical composition and biological activities  of 10 wild growing taxa of genus  Allium  sect. Codonoprasum  (A. carinatum  subsp. pulchellum,  A. carinatum  subsp.  carinatum,  A. fuscum  var.  gracile,  A. fuscum  var. fuscum,  A. flavum  subsp.  flavum,  A. melanantherum,  A. oleraceum,  A. paniculatumsubsp. marginatum, A. pallens subsp. tenuiflorum and A. rhodopeum) were investigated. The samples were  collected from 27 locations in Serbia. The aim of the study was to obtain data on the content of biologically active compounds in extracts of  these unexplored species of the genus Allium and to determine their potential medicinal value.Phytochemical caracterisation included: headspace GC-MS analysis of fresh bulb volatiles, LC-DAD-MS and LC-MS-MS qualitative analysis of methanol extracts, LC-MS-MS quantitative analysis of 44 selected phenolic compounds in methanol extracts, determination of total monomeric anthocyanins content and alliinase activity. In order to assess the biological potential of methanol extracts, the antioxidant, anti-inflammatory, antimicrobial, antimutagenic, genotoxic and antiproliferative activities of  the extracts were studied.Summing up all the results obtained, it can be concluded that species of genus Allium  sect.  Codonoprasum  are rich sources of biologically active compounds with a broad spectrum of biological activities. Dimethyl disulfide is the most dominant and often the only volatile component of most species, which is significant from chemotaxonomic point of view. The methanol extracts of investigated species contain high levels of flavonoids (primarily quercetin derivatives). Specificity of  A. pallens  and A.  oleraceum  extracts is that they do not contain rutin, but contain hyperoside, while small quantity of phenolic compounds  is characteristic for  A. rhodopeum  extract. All investigated species, except of A. flavum, are rich in anthocyanins. Alliinase activity was high in  all examined species. Most of the extracts, except  A. carinatum  and  A. melanantherum  extracts, express considerable antioxidant activity,  while extracts of  A. flavum,  A. rhodopeum,  A. paniculatum  and  A. oleraceum  are potent anti-inflammatory agents. The investigated  Allium  extracts did not show antimicrobial and antimutagenic activity. Also, the extracts did not express genotoxic effect on healthy tissue cells (except the weak genotoxic effects of aerial parts extract of  A. flavum), indicating that the use  of these species as a food or as a drug is safe. Whole plant extracts of  A. paniculatum  and  A. rhodopeum, as well as aerial parts extract of  A. melanantherum showed strong antiproliferative activity (with a favorable  non-tumor/tumor ratios) and induced apoptosis in tumor cells, suggesting that these plants have a high potential for application in antitumor therapy.
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Arts, Mariken J. T. J. "Assessing antioxidant activity." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8676.

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O'Reilly, James Daniel. "Antioxidant activity of dietary flavonoids." Thesis, King's College London (University of London), 1999. https://kclpure.kcl.ac.uk/portal/en/theses/antioxidant-activity-of-dietary-flavonoids(10c771a4-169d-405b-a1cd-354e86ebd109).html.

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Books on the topic "Antioxidant and antimutagenic activity"

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Apak, Resat, Esra Capanoglu, and Fereidoon Shahidi, eds. Measurement of Antioxidant Activity & Capacity. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119135388.

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Russell, Vincent Patric. Antioxidant activity of the isomers of butylated hydroxyanisole. Salford: University of Salford, 1985.

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McClements, D. J., Eric Decker, and Ryan J. Elias. Oxidation in foods and beverages and antioxidant applications: Understanding mechanisms of oxidation and antioxidant activity. Oxford: Woodhead Pub., 2010.

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Handbook of naturally occurring compounds with antioxidant activity in plants. New York: Nova Science, 2006.

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Maxwell, Simon Robert Jenkinson. An enhanced chemiluminescent assay for antioxidant activity in biological fluids. Birmingham: University of Birmingham, 1995.

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Boskou, Dimitrios, Ioannis P. Gerothanassis, and Panagiotis Kefalas. Natural antioxidant phenols: Sources, structure-activity relationship, current trends in analysis and characterisation. Kerala, India: Research Signpost, 2006.

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Soleas, George J. The analysis of polyphenolic constituents in wine and their relationship to antioxidant activity. Ottawa: National Library of Canada, 1997.

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Egerton, Caroline Greta. Studies on physical fitness, activity levels, diet and antioxidant status in children and adolescents. [s.l: The Author], 1993.

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Antioxidant Activity of Polyphenolic Plant Extracts. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-0365-0289-2.

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Antioxidant activity of green tea in vivo. Society of Chemical Industry, 1994.

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Book chapters on the topic "Antioxidant and antimutagenic activity"

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Lozovik, G., M. Shlyankevich, and A. Sergeev. "Antimutagenic Activity of Natural Carotenoid Extracts." In Advances in Experimental Medicine and Biology, 229. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-0939-8_29.

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Patras, Ankit, Yvonne V. Yuan, Helena Soares Costa, and Ana Sanches-Silva. "Antioxidant activity of phytochemicals." In Handbook of Plant Food Phytochemicals, 452–72. Oxford: John Wiley & Sons Ltd, 2013. http://dx.doi.org/10.1002/9781118464717.ch20.

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Sundaram Sanjay, Sharda, and Ashutosh Kumar Shukla. "Mechanism of Antioxidant Activity." In Potential Therapeutic Applications of Nano-antioxidants, 83–99. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1143-8_4.

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Kuroda, Yukiaki. "Antimutagenic Activity of Vitamins in Cultured Mammalian Cells." In Antimutagenesis and Anticarcinogenesis Mechanisms II, 233–56. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4615-9561-8_20.

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Bast, Aalt, and Guido R. M. M. Haenen. "Pharmaceutical Compounds with Antioxidant Activity." In Developments in Cardiovascular Medicine, 71–83. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4375-2_5.

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Shahidi, Fereidoon, and Chandrika M. Liyana-Pathirana. "Antioxidant Activity of Sesame Fractions." In ACS Symposium Series, 33–45. Washington, DC: American Chemical Society, 2005. http://dx.doi.org/10.1021/bk-2005-0909.ch004.

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Rodríguez-Malaver, Antonio Jesús. "Antioxidant Activity of Pot-Honey." In Pot-Honey, 475–80. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4960-7_34.

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Capanoglu, Esra, Senem Kamiloglu, Sema Demirci Cekic, Kevser Sozgen Baskan, Asli Neslihan Avan, Seda Uzunboy, and Resat Apak. "Antioxidant Activity and Capacity Measurement." In Plant Antioxidants and Health, 1–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-45299-5_22-1.

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Hoshina, Chie, Kouji Tomita, and Yuzo Shioi. "Antioxidant Activity of Chlorophylls: Its Structure-Activity Relationship." In Photosynthesis: Mechanisms and Effects, 3281–84. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-3953-3_766.

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Tsao, Rong, Mingchen Wang, and Zeyuan Deng. "Lutein: Separation, Antioxidant Activity, and Potential Health Benefits." In Antioxidant Measurement and Applications, 352–72. Washington, DC: American Chemical Society, 2007. http://dx.doi.org/10.1021/bk-2007-0956.ch023.

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Conference papers on the topic "Antioxidant and antimutagenic activity"

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Xu, H., G. Xia, and Y. Bao. "Antioxidant, antimutagenic and antitumor activities of flavonoids from the seed shells of Juglans mandshurica." In Proceedings of the 3rd Annual Congress on Advanced Engineering and Technology (CAET 2016). P.O. Box 11320, 2301 EH Leiden, The Netherlands, e-mail: Pub.NL@taylorandfrancis.com, www.crcpress.com – www.taylorandfrancis.com: CRC Press/Balkema, 2016. http://dx.doi.org/10.1201/9781315387222-32.

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POZDNYAKOVA, Olga G., Galina A. BELAVINA, Alexander N. AVSTRIEVSKIKH, Andrey A. VEKOVTSEV, and Valery M. POZNYAKOVSKY. "Antioxidant Phytocomplex with Antitumor Activity." In XVIII International Scientific and Practical Conference "Modern Trends in Agricultural Production in the World Economy". Sibac, 2020. http://dx.doi.org/10.32743/kuz.agri.2020.1-11.

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Jácome, A.L., Morocho. "Antioxidant activity of microalgae extracts." In 8th International conference on Research in Engineering, Science and Technology. Acavent, 2018. http://dx.doi.org/10.33422/8rest.2018.11.42.

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"Antioxidant Activity of some Amidine Derivatives." In International Conference on Chemical, Agricultural and Biological Sciences. Emirates Research Publishing, 2015. http://dx.doi.org/10.17758/erpub.er915010.

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Hegedus, Ondrej. "ANTIOXIDANT ACTIVITY DETERMINATION OF HORTICULTURAL CROPS." In 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/6.1/s25.070.

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Tarun, E., N. Tarasevich, T. Golovach, and R. Romanovich. "ANTIOXIDANT ACTIVITY OF FERMENTED COLOSTRUM EXTRACTS." In SAKHAROV READINGS 2020: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. Minsk, ICC of Minfin, 2020. http://dx.doi.org/10.46646/sakh-2020-2-181-184.

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Souza, Gabriel L. C. de, Shawan K. C. Almeida, and Rodrigo A. Mendes. "Antioxidant activity of myricetin-like compounds." In VII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Editora Letra1, 2018. http://dx.doi.org/10.21826/9788563800374002.

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Chukhareva, Natalia. "ANTIOXIDANT ACTIVITY OF PEAT HUMIC ACIDS." In 17th International Multidisciplinary Scientific GeoConference SGEM2017. Stef92 Technology, 2017. http://dx.doi.org/10.5593/sgem2017/32/s13.003.

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Djarkasi, G. S. Suhartati, Lana E. Lalujan, Erny Nurali, and Maria F. Sumual. "Antioxidant activity of karimenga (Acorus calamus)." In PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCES AND MEDICAL ENGINEERING (ICBME2019): Towards innovative research and cross-disciplinary collaborations. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5125555.

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Gorbunova, E. A., and M. N. Gorbunova. "Antioxidant activity of new azanorbornene copolymers." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018395.

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Reports on the topic "Antioxidant and antimutagenic activity"

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Kim, Yuan, Edward M. Steadham, Steven M. Lonergan, and Elisabeth J. Huff-Lonergan. Antioxidant Capacity of Calcium Lactate on m-Calpain Activity In Vitro. Ames (Iowa): Iowa State University, January 2009. http://dx.doi.org/10.31274/ans_air-180814-1237.

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Balabanova, Vessela, Yulian Voynikov, Gökhan Zengin, Reneta Gevrenova, and Dimitrina Zheleva-Dimitrova. A View on Antioxidant and Enzyme Inhibitory Activity of Senecio hercynicus Herbal Drugs. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2020. http://dx.doi.org/10.7546/crabs.2020.12.06.

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Darenskaya, M. A., A. A. Semendyaev, D. A. Stupin, L. A. Grebenkina, I. N. Danusevich, L. I. Kolesnikova, and S. I. Kolesnikov. ACTIVITY OF ANTIOXIDANT ENZYMES IN REGIONAL AREA BLEEDING WITH VARICOSE EXPANSION OF THE VALVES OF THE SMALL PELVIS IN WOMEN. EXPERIMENTAL BULLETIN BIOLOGY AND MEDICINE. - 2020, 2020. http://dx.doi.org/10.18411/2413-1008-2020-12088.

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Paul, Satashree. Oxidative Stress: A Cause of Male Infertility. Science Repository OÜ, October 2020. http://dx.doi.org/10.31487/sr.blog.10.

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