Log in

Relevant bibliographies by topics / Antioxidant and DNA damage / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Antioxidant and DNA damage.

Dissertations / Theses on the topic 'Antioxidant and DNA damage'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Antioxidant and DNA damage.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Watters, Joanne Lee Satia Jessie. "Antioxidant nutrients and oxidative DNA damage in healthy African American and White adults." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,1019.

Full text

Abstract:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Nutrition, School of Public Health." Discipline: Nutrition; Department/School: Public Health.

APA, Harvard, Vancouver, ISO, and other styles

2

Lee-Bellantoni, Margaret S. "Antioxidant defense and redox responses to telomere homolog oligonucleotides in human dermal fibroblasts: a model for investigating redox signaling responses to DNA damage." Thesis, Boston University, 2005. https://hdl.handle.net/2144/37162.

Full text

Abstract:

Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>It has been demonstrated that oligonucleotides homologous to the 3' telomere repeat sequence TTAGGG (T-oligos) stimulate DNA damage responses that are also induced by disruption of the telomere loop structure

APA, Harvard, Vancouver, ISO, and other styles

3

Delinassios, George. "UVA-induced oxidative stress and DNA damage in human skin cells and photoprotection by antioxidant compounds." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/uvainduced-oxidative-stress-and-dna-damage-in-human-skin-cells-and-photoprotection-by-antioxidant-compounds(f9b2b64f-de71-42d4-8787-05c30af81145).html.

Full text

Abstract:

Solar ultraviolet radiation (UVR), especially UVA (320-400nm), is a potent inducer of oxidative DNA damage in human skin cells. Such damage has mutagenic and carcinogenic potential. It is therefore important to understand the mechanisms that control its extent, and develop means of protecting against such damage. The main purpose of this work was to develop reliable quantitative methods to measure UVR-induced oxidative stress, assess its biological consequences and its inhibition, in human skin cells in vitro. Most of this work studied the effects of UVA radiation, as this is the major (>95

APA, Harvard, Vancouver, ISO, and other styles

4

Tang, Hei-man Vincent, and 鄧希文. "Characterization of yeast peroxiredoxin tsa1p in DNA damage response." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085921.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Tang, Hei-man Vincent. "Characterization of yeast peroxiredoxin tsa1p in DNA damage response." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085921.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Dean, Jennifer Dawn. "Flavone the molecular and mechanistic study of how a simple flavonoid protects DNA from oxidative damage /." [Johnson City, Tenn. : East Tennessee State University], 2003. http://etd-submit.etsu.edu/etd/theses/available/etd-1118103-040008/unrestricted/DeanJ111803a.pdf.

Full text

Abstract:

Thesis (M.S.)--East Tennessee State University, 2003.<br>Title from electronic submission form. ETSU ETD database URN: etd-1118103-040008. Includes bibliographical references. Also available via Internet at the UMI web site.

APA, Harvard, Vancouver, ISO, and other styles

7

Abdul, Salam Safnas Farwin. "Biochemistry of Reactive Oxygen Species in Selective Cancer Cell Toxicity and Protection of Normal Cells." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511880706270521.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Twigg, Jeremy Philip. "DNA damage in human spermatozoa : free radicals, sperm function and ICSI." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391610.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kaezer, Andrea da Rocha. "Efeito antimutagênico, antigenotóxico, antiobesidade e antioxidante da Ilex paraguariensis (erva-mate)." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7016.

Full text

Abstract:

O extrato aquoso de erva-mate, obtido a partir de folhas secas de Ilex paraguariensis, é uma bebida amplamente consumida na América do Sul. Inicialmente, nosso objetivo foi caracterizar os compostos presentes nas amostras de erva-mate disponíveis no mercado brasileiro (CH: chimarrão; T: chá mate torrado; G: chá mate torrado, comercialmente acondicionado em garrafas ou C: em copos; TS: chá mate torrado solúvel A mutagenicidade, citotoxicidade e antimutagenicidade de todas as amostras também foram avaliadas atavés do Teste de Ames na presença e na ausência de ativação metabólica. Em seguida, ana

APA, Harvard, Vancouver, ISO, and other styles

10

England, Timothy George. "Oxidative DNA damage as a marker of cancer risk : effect of dietary antioxidants." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312186.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Thomas-Ahner, Jennifer M. "Gender differences in UVB induced cutaneous inflammation and skin carcinogenesis." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1179949864.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kaniewska, Joanna J. "Effect of increased fruit and vegetable intake on phytophenolic levels in humans and the impact on antioxidant capacity, DNA damage and protein expression." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225810.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Chen, Hong, and 陳紅. "A study of male accessory sex glands in protecting: the genomic integrity of sperm in the golden hamster(Mesocricetus auratus)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245195.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ferreira, Simone Gomes. "Estudo dos efeitos da melatonina sobre danos ao DNA induzidos pela ciclofosfamida em ratos wistar pinealectomizados." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-15092008-131230/.

Full text

Abstract:

Este estudo investigou o efeito protetor da melatonina sobre os danos ao DNA induzidos pela ciclofosfamida (20 e 50mg/kg) sobre as aberrações cromossômicas, fragmentação do DNA, ciclo celular e os sítios sensíveis a Fpg pelo Ensaio Cometa. Os níveis de RNAm de MGMT, p53, p21, Bax, Bcl-2, Top1, CSB e XPF foram analisados por qPCR. Após a remoção cirúrgica da glândula pineal, os animais foram tratados com 1 mg/kg de mel via oral durante 15 dias. Como resultados demonstramos que a melatonina foi capaz de reverter completamente o quadro de aberrações cromossômicas induzidas pela ciclofosfamida, in

APA, Harvard, Vancouver, ISO, and other styles

15

Schmid, Ursula. "Protection against oxidative DNA damage by antioxidants, hormone-receptor blockers and HMG-CoA-reductase inhibitors." Doctoral thesis, kostenfrei, 2008. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Oliveira, Larissa Ragozo Cardoso de [UNESP]. "Efeito da terapia antituberculose na expressão dos receptores TLR-2 e 4, do fator de transcrição Foxp3, da Óxido Nítrico Sintase Induzível, no perfil de citocinas e nas alterações genóticas." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/89949.

Full text

Abstract:

Made available in DSpace on 2014-06-11T19:24:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-15Bitstream added on 2014-06-13T19:10:40Z : No. of bitstreams: 1 oliveira_lrc_me_botfm.pdf: 589752 bytes, checksum: 4d9dc2b0e2961ff5f5d54602fbf367a2 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Universidade Estadual Paulista (UNESP)<br>A tuberculose permanece como um dos principais problemas de saúde pública no Brasil e no mundo. Tem como principal agente o Mycobacterium tuberculosis, e é uma doença letal sem tratamento, e seu controle é dificultado pel

APA, Harvard, Vancouver, ISO, and other styles

17

Thomas-Ahner, Jennifer Marie. "Gender differences in UVB induced cutaneous inflammation and skin carcinogenesis." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179949864.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Barbosa, Susiane de Oliveira. "Efeito da suplementação com licopeno sobre o estresse oxidativo pulmonar induzido por lesão pulmonar aguda experimental." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153467.

Full text

Abstract:

Submitted by Susiane de Oliveira Klefens Barbosa (btsusi@yahoo.com.br) on 2018-04-10T12:20:42Z No. of bitstreams: 1 TESE _ Susiane de Oliveira Klefens Barbosa 2018.pdf: 1518184 bytes, checksum: 6d5b1e7635afb78dfefe1890eea01151 (MD5)<br>Approved for entry into archive by Luciana Pizzani null (luciana@btu.unesp.br) on 2018-04-10T19:22:58Z (GMT) No. of bitstreams: 1 barbosa_so_dr_bot.pdf: 1518184 bytes, checksum: 6d5b1e7635afb78dfefe1890eea01151 (MD5)<br>Made available in DSpace on 2018-04-10T19:22:58Z (GMT). No. of bitstreams: 1 barbosa_so_dr_bot.pdf: 1518184 bytes, checksum: 6d5b1e7635afb78dfef

APA, Harvard, Vancouver, ISO, and other styles

19

Oliveira, Larissa Ragozo Cardoso de. "Efeito da terapia antituberculose na expressão dos receptores TLR-2 e 4, do fator de transcrição Foxp3, da Óxido Nítrico Sintase Induzível, no perfil de citocinas e nas alterações genóticas /." Botucatu : [s.n.], 2012. http://hdl.handle.net/11449/89949.

Full text

Abstract:

Orientador: Sueli Aparecida Calvi<br>Banca: Lenice do Rosário de Souza<br>Banca: Fátima Regina Vitani Moreno<br>Resumo: A tuberculose permanece como um dos principais problemas de saúde pública no Brasil e no mundo. Tem como principal agente o Mycobacterium tuberculosis, e é uma doença letal sem tratamento, e seu controle é dificultado pela longa duração e ausência de marcadores, para medir o sucesso ou a falha deste. Os TLRs são receptores que após o reconhecimento de produtos microbianos, ativam a resposta inata e adaptativa. Assim, os receptores TLRs e as citocinas possuem um papel chave na

APA, Harvard, Vancouver, ISO, and other styles

20

Turcatel, Elias. "Investigação da capacidade antioxidante, perfil inflamatório e dano ao DNA em pacientes com Doença de Gaucher tratados com a terapia de reposição enzimática." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/129765.

Full text

Abstract:

A doença de Gaucher (DG) é uma doença de armazenamento lisossômico causada por uma mutação no gene que codifica a enzima β-glicosidase, a deficiência dessa enzima provoca o acúmulo de glicosilceramidas nos lisossomos do sistema retículo endotelial. A DG é divididas em três tipos, o tipo I é a forma mais branda e mais prevalente da doença. As consequências desta doença incluem hepatoesplenomegalia, deficiências ósseas, manifestações hematológicas e neurodegeneração, porém os mecanismos fisiopatológicos ainda não estão totalmente esclarecidos. Portanto, a fim de esclarecer a fisiopatologia envol

APA, Harvard, Vancouver, ISO, and other styles

21

Åsgård, Rikard. "Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-217886.

Full text

Abstract:

Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes. The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. We also used antioxidants as tools to determine the mechanisms behind genotoxicity induced by mutagenic pro-oxidative agents in mouse lymphoma cells. Several techniques were used to measure oxidative stress and DNA damage, but the main technique used was

APA, Harvard, Vancouver, ISO, and other styles

22

Ogusucu, Renata. "Interações de peroxirredoxinas citossólicas da levedura Saccharomyces cerevisiae com peróxidos. Estudos cinéticos e funcionais." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25062009-143107/.

Full text

Abstract:

As peroxirredoxinas constituem uma família de tiol-proteínas, que reduzem peróxido de hidrogênio, peróxidos orgânicos e peroxinitrito a água, álcool e nitrito, respectivamente, utilizando equivalentes redutores fornecidos pela tiorredoxina, tiorredoxina redutase e NADPH. As peroxirredoxinas são enzimas abundantes (constituem aproximadamente 0,7 % do total de proteínas solúveis presentes em leveduras) e foram identificadas em diversas espécies de animais, plantas e bactérias, porém seu papel fisiológico ainda é discutido. Até recentemente, as peroxirredoxinas eram consideradas pouco eficientes

APA, Harvard, Vancouver, ISO, and other styles

23

Milella, Maria Serena. "Study of molecular mechanisms and pharmacological approaches of Alkaptonuria's disease." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1204563.

Full text

Abstract:

Alkaptonuria (AKU) is an autosomal recessive disorder, called also Black Bone Disease, for the characteristic dark coloration that some tissues and parts of the body assumed. The pathology is caused by the failure of the enzyme homogentisate 1,2- dioxygenase (HGD), that leads the accumulation of the metabolic intermediate homogentisic acid (HGA), derived by tyrosine. HGA highly reactivity triggers the formation of HGA-derived oxidized products, that react with cellular macromolecules, causing a significant generation of ROS and occurrence of oxidative stress. The ongoing oxidative stress statu

APA, Harvard, Vancouver, ISO, and other styles

24

Onobun, Emmanuel. "A Novel Method for Synthesis of Hydroxytyrosol." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3267.

Full text

Abstract:

Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol mak

APA, Harvard, Vancouver, ISO, and other styles

25

Rytter, Elisabet. "Effect of Dietary Antioxidants on Oxidative Stress, Inflammation and Metabolic Factors : Studies in Subjects with Overweight and with Type 2 Diabetes." Doctoral thesis, Uppsala universitet, Oxidativ stress och inflammation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134938.

Full text

Abstract:

Observational studies have indicated that fruit and vegetables, and dietary antioxidants may play an important role in reducing the risk of chronic diseases, potentially by affecting pathogenic mechanisms such as oxidative stress and inflammation. Clinical trials investigating the effects of supplementation with single or a few antioxidants in high doses have, however, shown inconsistent results and thus have not been able to support the observational findings. It was therefore hypothesised that a supplement, containing a combination of antioxidants mainly extracted from fruit and vegetables

APA, Harvard, Vancouver, ISO, and other styles

26

Zanuto, Marcia Elena. "Efeito da suplementação de β-caroteno sintético no DNA e no metabolismo de células hepáticas de ratos recebendo etanol." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-18092017-120853/.

Full text

Abstract:

A suplementação de β-caroteno em fumantes e alcoólatras pode promover efeitos indesejáveis, manifestando a característica pró-oxidante deste carotenóide. Sabendo que o fígado é o principal órgão de armazenamento de vitamina A e (β-caroteno, e local de oxidação do etanol, o presente estudo buscou investigar no fígado de ratos, a influência da suplementação de (β-caroteno isolado ou associado ao etanol, sobre o metabolismo celular, danos no DNA, proliferação celular e função da proteína p53. Os ratos receberam dietas líquidas contendo (β-caroteno (24mg/L dieta) com (GAB) ou s

APA, Harvard, Vancouver, ISO, and other styles

27

Colombo, Natália Beatriz Rigoldi. "Ação dos compostos antioxidantes na redução do estresse oxidativo em modelo experimental de câncer de pulmão: estudo do pequi (Caryocar brasilense camb)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-27082014-092810/.

Full text

Abstract:

Introdução. Uma alimentação rica em antioxidantes pode prevenir e reparar danos oxidativos causados pelas espécies reativas de nitrogênio e oxigênio, como o dano no DNA e a peroxidação lipídica e pode reduzir o risco de câncer, aterosclerose e outras doenças degenerativas. A polpa do Caryocar Brasiliense Camb, mais conhecido como pequi, é uma fruta do cerrado brasileiro que possui altos níveis de antioxidantes como os carotenóides, vitamina C e E e compostos fenólicos. Objetivos. Verificar a atividade antioxidante do óleo e do extrato da polpa do pequi na diminuição do estresse oxidativo em um

APA, Harvard, Vancouver, ISO, and other styles

28

Sunter, Nicola. "DNA Damage Responses." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489314.

Full text

Abstract:

The histone H2AX has been established as a reliable biomarker of DNA damage, becoming phosphorylated rapidly following damage in discrete foci which can be correlated with DNA DSB number. In the present study, the phosphorylation of H2AX was used as a marker of DNA DSB damage to compare and contrast the damage induced by ionizing radiation, the topo II poison, etoposide, and the topo II catalytic inhibitor, ICRF-193. To examine the DNA damage numbers at time-points in the 24 hours following exposure to these damaging agents. Topo lIP null cells were used to investigate the contribution of topo

APA, Harvard, Vancouver, ISO, and other styles

29

Pereira, Lindalva. "Efeitos dos herbicidas clomazone e ametrina em parâmetros funcionais da espécie de peixe neotropical Prochilodus lineatus." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/1776.

Full text

Abstract:

Made available in DSpace on 2016-06-02T19:29:51Z (GMT). No. of bitstreams: 1 4461.pdf: 864627 bytes, checksum: 65403dae241e7d12b25fab4c53a4ee0b (MD5) Previous issue date: 2012-03-30<br>The use of biomarkers can provide a great help in the evaluation of the damages caused by pesticides in aquatic organisms. The present study aimed to verify the toxicity of clomazone and ametryn for a tropical freshwater fish Prochilodus lineatus by using different parameters in fish exposed for 96h to clomazone (1, 5 and 10 mg.L-1) and to ametryn, as the commercial product GesapaxR500 or in its pure form, in

APA, Harvard, Vancouver, ISO, and other styles

30

Fazendeiro, Marta Sofia Pereira Pingarilho. "DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels." Doctoral thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/10000.

Full text

Abstract:

RESUMO:Em 1994 a acrilamida (AA) foi classificada pela IARC como um provável cancerígeno para o homem. Para além da utilização de AA em numerosas aplicações industriais, a AA está também presente numa grande variedade de alimentos ricos em amido e processados a temperaturas elevadas. Esta exposição através da ingestão de produtos alimentares despoletou elevadas preocupações ao nível do risco para a saúde pública e poderá implicar um risco adicional para o aparecimento de cancro. A glicidamida (GA), o metabolito epóxido formado a partir da oxidação da AA provavelmente através do citocromo P450

APA, Harvard, Vancouver, ISO, and other styles

31

Thornley, Andrew Charles. "Antioxidant defence and autoxidative damage in neoplastic disease." Thesis, University of Surrey, 1987. http://epubs.surrey.ac.uk/848118/.

Full text

Abstract:

The principal factors governing antioxidant defence and lipid peroxidation in vitro have been determined for neoplastic and normal tissues, from mice, bearing Lewis lung carcinomas. These parameters were measured at varying intervals after the intramuscular transplantation of Lewis lung carcinoma cells in C57BL6 mice. The activities of glutathione peroxidase (EC 1.11.1.9), superoxide dismutase (EC. 1.15.1.1), gamma glutamylcysteine synthetase (EC 6.3.2.2), and catalase (EC. 1.11.1.6) were similar in tumour tissue to those of lung, the tissue of origin. Glutathione reductase (EC. 1.6.4.2) and g

APA, Harvard, Vancouver, ISO, and other styles

32

Håkansson, Pelle. "Ribonucleotide reductase and DNA damage." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-706.

Full text

Abstract:

A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. The rate-limiting step in de novo biosynthesis of dNTPs is catalyzed by the enzyme ribonucleotide reductase (RNR). The classic eukaryotic RNR enzyme consists of a large and a small subunit. Together, these subunits form a heterotetrameric RNR complex. The larger subunit harbours active sites whereas the smaller s

APA, Harvard, Vancouver, ISO, and other styles

33

Håkansson, Pelle. "Ribonucleotide reductase and DNA damage /." Umeå : Medicinsk biokemi och biofysik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-706.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Johnstone, Elaine Claire. "Ifosfamide metabolism and DNA damage." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264417.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Aldosari, Sahar. "Assessment of DNA damage and DNA damage response and repair in dormancy-enriched leukemia cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47257/.

Full text

Abstract:

Acute myeloid leukaemia (AML) is a heterogeneous myeloid malignancy characterized by clonal expansion of abnormal/immature hematopoietic precursor cells in the bone marrow. A side compartment in the BM niche consists of abnormal, quiescent cells, which are called dormant leukemic initiating cells (DLICs). Patients with AML tend to respond well to remission induction chemotherapy, but relapse is common because current therapies cannot completely eradicate leukemic cells. It is widely accepted that CD34+CD38− DLICs are more resistant to chemotherapy and that they contribute to drug resistance an

APA, Harvard, Vancouver, ISO, and other styles

36

Farooq, Sabya. "Free radical induced oxidative DNA damage." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30749.

Full text

Abstract:

Oxidative DNA damage has been implicated in processes such as carcinogenesis, mutagenesis, ageing and cell death. Reactive oxygen species (ROS) such as superoxide (O2), hydrogen peroxide (H2O 2) and hydroxyl radical (OH*) are produced in mammalian cells as a result of aerobic metabolism. However excess generation of these species by endogenous or exogenous sources can result in damage to DNA, producing a large number of sugar and base lesions. In order to understand the biological consequences of such free radical induced damage it is essential to characterise and quantitate this damage. This

APA, Harvard, Vancouver, ISO, and other styles

37

Bykov, Vladimir J. "UV-induced DNA damage in humans /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3345-6/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Lampus, Daniele Jacopo. "Towards IR Probes of DNA Damage." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518828.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Jansson, Martin D. "Regulation of the DNA damage response." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504493.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Kuimova, Marina K. "Designing infrared probes of DNA damage." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416394.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Alhebshi, H. "Molecular pathways controlling DNA damage response." Thesis, University of Salford, 2018. http://usir.salford.ac.uk/48475/.

Full text

Abstract:

P53 is inactivated in around 50 % of human neoplasms and more than 26,000 somatic mutations of the p53 have reported in human cancers. P53 network is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to repression of the cell cycle progression and induction of apoptosis. Consequently, the p53 protein is considered vital to cancer progression and treatment and has been the focus of intense research. TTC5 (Tetratricopeptide repeat domain 5) or STRAP was identified as p53 cofactor and a key component of the

APA, Harvard, Vancouver, ISO, and other styles

42

Yu, Emma Pei Kuen. "Mitochondrial DNA damage, dysfunction and atherosclerosis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648537.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Parkes, Eileen. "The immune response to DNA damage." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709693.

Full text

Abstract:

Breast cancer is a highly heterogenous disease and current methods of treatment selection in the clinic do not take account of this heterogeneity. In order to improve outcomes in breast cancer, a personalised approach is required. Previously we identifed a DNA damage response deficient (DDRD) molecular subgroup within breast cancer. A 44-gene expression assay prospectively identifying this subgroup was validated as predicting benefit from DNA-damaging chemotherapy. This subgroup was defined by interferon signalling. In this study the biology identified by the subgroup is addressed, identifying

APA, Harvard, Vancouver, ISO, and other styles

44

Clement, Amy Marie. "The Antioxidant Defense Network: Synergistic Combinations to Prevent Oxidative Damage." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1549.

Full text

Abstract:

One of the matchless ironies of the human body is its requirement for the highly reactive oxygen molecule, which has been clearly implicated in many diseases and the aging processes. Oxidants produced by metabolic processes damage cells by starting chemical chain reactions including oxidation of DNA and proteins as well as lipid peroxidation. Damage to DNA can cause mutations and lead to cancer if not reversed by DNA repair mechanisms. Damage to proteins causes enzyme inhibition, denaturation and protein degradation. Lipid peroxidation can cause cell lysis as well as creating mutagenic and car

APA, Harvard, Vancouver, ISO, and other styles

45

Ndlebe, Thabisile S. "Oxidative Damage in DNA: an Exploration of Various DNA Structures." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05112006-154326/.

Full text

Abstract:

Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2007.<br>Donald F. Doyle, Committee Member ; Bridgette Anne Barry, Committee Member ; Dr. Gary B. Schuster, Committee Chair ; Nicholas V. Hud, Committee Member ; Roger M. Wartell, Committee Member.

APA, Harvard, Vancouver, ISO, and other styles

46

Krusong, Kuakarun. "Recognition and repair of DNA damage by uracil DNA glycosylase." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417133.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Cooley, Nicola. "Quantitative associations betweenn DNA damage, DNA repair and celluar outcomes." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499845.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Kaliyaperumal, Saravanan. "hMSH6 Protein Phosphorylation: DNA Mismatch Repair or DNA Damage Signaling?" Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1242933021.

Full text

Abstract:

Dissertation (Ph.D.)--University of Toledo, 2009.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 174-180, p. 201-238.

APA, Harvard, Vancouver, ISO, and other styles

49

Mikhed, Yuliya [Verfasser]. "The role of DNA damage in the pathogenesis of nitrate tolerance - nitrosative versus oxidative DNA damage / Yuliya Mikhed." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1080187529/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Karakoula, Aikaterini. "Studies on UV-induced DNA damage and repair to human DNA." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29692.

Full text

Abstract:

The induction and repair of DNA damage has been shown to occur heterogeneously throughout the mammalian genome. As a consequence, analysis of these parameters at a global genome level may not reflect important gene-level events. Few techniques have been established to explore quantitatively gene-specific DNA damage and repair. Most of these are PCR-based assays and are relatively insensitive, relying on decreased PCR amplification arising from damage in template DNA. In this study, a quantitative assay that combines specific immunocapture of damaged DNA by an antiserum specific for thymine dim

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!