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Journal articles on the topic 'Antioxidant and DNA damage'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

DOĞAN, Mustafa. "INVESTIGATION OF DNA DAMAGE AFTER FREEZİNG AND THAWING OF FUNCTIONAL RAINBOW TROUT (Oncorhynchus mykiss) SPERM." International Journal of Agriculture and Environmental Research 10, no. 06 (2024): 902–12. https://doi.org/10.51193/ijaer.2024.10607.

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During thawing and freezing of the sperm cell, the DNA structure may be damaged at different levels due to various internal and external reasons. In this study, DNA damage after freezing and thawing of functional masculinized rainbow trout (Oncorhynchus mykiss) semen was examined. Freezing was carried out using different dilution rates (1/3, 1/6, 1/9) and different doses of 1mM, 2 mM and 4 mM Ascorbic acid (antioxidant). In order to detect these damages that may be seen in the sperm DNA after the thawing process, the Comet assay method was used. The results showed that the group using 1/9 dilu

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2

Livingston, Justin R., Jacob J. Peterson, Gabriel A. Martinez, et al. "The Antioxidant and DNA Repair Activities of Resveratrol, Piceatannol, and Pterostilbene." Journal of Food Research 4, no. 5 (2015): 9. http://dx.doi.org/10.5539/jfr.v4n5p9.

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<p>Lifestyle diseases represent a large burden on developed societies and account for much morbidity worldwide. Research has shown that eating a diet rich in fruit and vegetables helps to ameliorate and prevent some of these diseases. Antioxidants found in fruits and vegetables may provide a substantial benefit in reducing disease incidence. This study examines the antioxidant properties of resveratrol, piceatannol, and pterostilbene, and the ability of Burkitt’s Lymphoma (Raji) cells to uptake these three antioxidants. It also studies the effect of the antioxidants in protecting against

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Davison, G. W., C. M. Hughes, and R. A. Bell. "Exercise and Mononuclear Cell DNA Damage: The Effects of Antioxidant Supplementation." International Journal of Sport Nutrition and Exercise Metabolism 15, no. 5 (2005): 480–92. http://dx.doi.org/10.1123/ijsnem.15.5.480.

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The purpose of this investigation was to determine the effects of antioxidant supplementation on DNA damage following exercise. Fourteen subjects were randomly assigned to one of two groups and required to ingest either antioxidants (400 mg α-lipoic acid, 200 mg co-enzyme Q10, 12 mg manganese, 600 mg vitamin C, 800 mg N-acetyl cysteine, 400 μg selenium, and 400 IU α-tocopherol per day) or placebos for 7 d. Exercise increased DNA damage, PS, FRAP, and LDH (P < 0.05), but not selectively between groups. LDH and PS concentration decreased 1 h post-exercise (P < 0.05), while LH concentration

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Wong, W. S. Fred, Tze Khee Chan, W. S. Daniel Tan, Hong Yong Peh, and Bevin P. Engelward. "Direct aeroallergen exposure disrupts the oxidant and antioxidant balance in human bronchial epithelial cells." Journal of Immunology 196, no. 1_Supplement (2016): 53.4. http://dx.doi.org/10.4049/jimmunol.196.supp.53.4.

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Abstract Exposure to aeroallergens is a major risk factor for asthma development. Allergen possessing proteolytic activity is capable of disrupting airway epithelium. Increasing evidence pointing to asthma as an epithelial disease, however, the underlying mechanisms that drive asthma are not fully elucidated. Here, we investigated the DNA damage potential of aeroallergens on human bronchial epithelial cells BEAS-2B, and elucidated the damaging mechanisms. We exposed BEAS-2B cells to house dust mite (HDM), and measured DNA damage by CometChip and DNA double strand breaks (DSBs) by γH2AX stainin

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Biswas, Jaydip, Dona Sinha, Sutapa Mukherjee, Soumi Roy, Maqsood Siddiqi, and Madhumita Roy. "Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal." Human & Experimental Toxicology 29, no. 6 (2010): 513–24. http://dx.doi.org/10.1177/0960327109359020.

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Groundwater arsenic contamination has been a health hazard for West Bengal, India. Oxidative stress to DNA is recognized as an underlying mechanism of arsenic carcinogenicity. A phytochemical, curcumin, from turmeric appears to be potent antioxidant and antimutagenic agent. DNA damage prevention with curcumin could be an effective strategy to combat arsenic toxicity. This field trial in Chakdah block of West Bengal evaluated the role of curcumin against the genotoxic effects of arsenic. DNA damage in human lymphocytes was assessed by comet assay and fluorescence-activated DNA unwinding assay.

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Merlin, J. P. Jose, Sabateeshan Mathavarajah, Graham Dellaire, Kieran P. J. Murphy та H. P. Vasantha Rupasinghe. "A Dietary Antioxidant Formulation Ameliorates DNA Damage Caused by γ-Irradiation in Normal Human Bronchial Epithelial Cells In Vitro". Antioxidants 11, № 7 (2022): 1407. http://dx.doi.org/10.3390/antiox11071407.

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Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to radiation that could result in malignancies, including lung cancer. Mortality rates are consistently higher in lung cancer, which is usually diagnosed at later stages of cancer development and progression. In this preliminary study, we examined the potential of an antioxidant formulation (AOX2) to reduce DNA damage using a cell model of human normal bronchial epithelial cells (BEAS-2B). Cells were exposed to γ-irradiation or smoke-related hydrocarbon 4[(acetoxymethyl)nitrosamino]-1 (3-pyridyl) 1-butanone (NNKO

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Costantini, David, Shelly Masi, Lyna Rachid, Marielle Beltrame, Mélanie Rohmer, and Sabrina Krief. "Mind the food: rapid changes in antioxidant content of diet affect oxidative status of chimpanzees." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320, no. 5 (2021): R728—R734. http://dx.doi.org/10.1152/ajpregu.00003.2021.

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The link between dietary antioxidants and oxidative status has been studied extensively in humans. Surprisingly, comparative data are not available from closely related species, such as chimpanzees, which evolved in environments characterized by strong fluctuations in the availability and quality of vegetable food sources. We tested the hypothesis that an abrupt decrease in dietary antioxidants would increase oxidative damages in captive chimpanzees ( Pan troglodytes), while a rapid increase in antioxidant intake would decrease oxidative damages accrued while on the low-antioxidant diet. An ab

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Das, Sonali, Raghavendra L. S. Hallur, and Asit Baran Mandal. "Evaluation of Semecarpus kurzii Engler from Bay Islands for oxidative DNA damage protective activity and in vitro antioxidant potential." Biomedicine 43, no. 02 (2023): 595–602. http://dx.doi.org/10.51248/.v43i02.1961.

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Introduction and Aim: Harnessing traditional knowledge of medicinal plants is important for the betterment of mankind. We must safeguard traditional knowledge from misuse by miscreants living in modern societies and knowledge must be available in the public domain for use in drug designing in the healthcare system. Since the beginning of recorded history, Indians have used plants as a source of medicine, and their cultural past is incredibly rich. This study was conducted to evaluate the oxidative stress-induced DNA damage prevention and antioxidant potential of Semecarpus kurzii found in the

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Elahe, Rezayi Poor Mashizei Dr.Mehri Khatami*. "EVALUATION OF ANTIOXIDANT PROPERTIES CHERRY FRUIT EXTRACT ON PREVENTION THE FAILURE OF DNA." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2051–56. https://doi.org/10.5281/zenodo.834970.

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Free radicals preface can result in many diseases such as atherosclerosis, heart diseases, geriatrics and cancer. These diseases are resulting from irregular production of ROS and unstable mechanism of antioxidant protection system.in order to reduction of harmful effects of ROS, natural antioxidants of plants and synthesis antioxidant can be used. It is shown that phenyl compounds, lipid peroxidations and oxidative damage to DNA in some plants can be prevented through cleaning some ROS such as Hydrogen peroxide and hydrocele radicals. Black Cherry is brimful of these compounds; in addition, r

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10

Shubham, Kumar1* Dhaval J. Kamothi2 Manju Gari3 Anshuk Sharma4 Meemansha Sharma5 Thakur Uttam Singh6 Dinesh Kumar7. "Effect of oxidative stress on fertility and therapeutic effect of antioxidants." Science World a monthly e magazine 3, no. 2 (2023): 276–80. https://doi.org/10.5281/zenodo.7685603.

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The imbalance between the generation of reactive oxygen species (ROS) and the antioxidant system's beneficial role in neutralizing and removing them causes oxidative stress. An overabundance of ROS generates a pathogenic reaction that damages cells and tissues. Natural antioxidant defense mechanisms exist to reduce the damaging effects of free radicals by neutralizing them and mending damaged cells. Reactive oxygen species (ROS) and antioxidants must coexist in this delicate and challenging equilibrium for healthy cell activity (Pham et al., 2008). ROS are produced as end products when cel

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11

Peng, Sui, Xiaofang Huo, Davood Rezaei, et al. "In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 2 (2014): G129—G139. http://dx.doi.org/10.1152/ajpgi.00085.2014.

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Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's esophagus. We have explored mechanisms whereby ursodeoxycholic acid (UDCA, a hydrophilic bile acid) protects against DCA-induced injury in vivo in patients and in vitro using nonneoplastic, telomerase-immortalized Barrett's cell lines. We took biopsies of Barrett's esophagus from 21 patients before and after esophageal perfusion with DCA (250 μM) at baseline and after 8 wk of oral UDCA treatment. DNA damage was assessed

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Cockfield, Jordan A., and Zachary T. Schafer. "Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells." Cancers 11, no. 8 (2019): 1208. http://dx.doi.org/10.3390/cancers11081208.

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Reactive oxygen species (ROS) are well known for their capacity to cause DNA damage, augment mutagenesis, and thereby promote oncogenic transformation. Similarly, agents that reduce ROS levels (antioxidants) are frequently thought to have anti-cancer properties given their propensity to minimize DNA damage and mutagenesis. However, numerous clinical studies focused on antioxidants suggest that this is a facile premise and that antioxidant capacity can be important for cancer cells in a similar fashion to normal cells. As a consequence of this realization, numerous laboratories have been motiva

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Gjorgieva, Darinka, Tatjana Kadifkova Panovska, Tatjana Ruskovska, Katerina Bačeva, and Trajče Stafilov. "Influence of Heavy Metal Stress on Antioxidant Status and DNA Damage inUrtica dioica." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/276417.

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Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level inUrtica dioicaleaves and stems were investigated. The samples are sampled from areas with different metal exposition. Metal content was analyzed by Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), for total antioxidants level assessment the Ferric-Reducing Antioxidant Power (FRAP) assay was used, and genomic DNA isolation from frozen plant samples was performed to obtain DNA fingerprints of investigated

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Someya, Yuduki, Sakine Kobayashi, Kazuya Toriumi, Shigeki Takeda, Noritaka Adachi, and Aya Kurosawa. "A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style." Genes 14, no. 2 (2023): 420. http://dx.doi.org/10.3390/genes14020420.

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Natural antioxidants derived from plants exert various physiological effects, including antitumor effects. However, the molecular mechanisms of each natural antioxidant have not yet been fully elucidated. Identifying the targets of natural antioxidants with antitumor properties in vitro is costly and time-consuming, and the results thus obtained may not reliably reflect in vivo conditions. Therefore, to enhance understanding regarding the antitumor effects of natural antioxidants, we focused on DNA, one of the targets of anticancer drugs, and evaluated whether antioxidants, e.g., sulforaphane,

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Park, Hee Jung, Ji Hye Jun, Jae Yeon Kim, et al. "Phosphatase of Regenerating Liver-1 (PRL-1)-Overexpressing Placenta-Derived Mesenchymal Stem Cells Enhance Antioxidant Effects via Peroxiredoxin 3 in TAA-Injured Rat Livers." Antioxidants 12, no. 1 (2022): 46. http://dx.doi.org/10.3390/antiox12010046.

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DNA damage repair is induced by several factors and is critical for cell survival, and many cellular DNA damage repair mechanisms are closely linked. Antioxidant enzymes that control cytokine-induced peroxide levels, such as peroxiredoxins (Prxs) and catalase (CAT), are involved in DNA repair systems. We previously demonstrated that placenta-derived mesenchymal stem cells (PD-MSCs) that overexpress PRL-1 (PRL-1(+)) promote liver regeneration via antioxidant effects in TAA-injured livers. However, the efficacy of these cells in regeneration and the role of Prxs in their DNA repair system have n

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Bae, Hyo-Kyung, In-Sun Hwang, Ji-Ye Kim, et al. "Antioxidant treatment during manipulation procedures prevents mitochondrial and DNA damage and enhances nuclear reprogramming of bovine somatic cell nuclear transfer embryos." Reproduction, Fertility and Development 27, no. 7 (2015): 1088. http://dx.doi.org/10.1071/rd14027.

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We tried to prevent the mitochondrial and DNA damage caused by mechanical stress-associated reactive oxygen species (ROS), and to improve the reprogramming of bovine somatic cell nuclear transfer (SCNT) embryos by antioxidant treatment during the manipulation procedures of SCNT. Bovine recipient oocytes and reconstituted oocytes were treated with antioxidants during manipulation procedures. The H2O2 level, mitochondrial morphology, membrane potential and apoptosis at the one-cell stage, and in vitro development and DNA methylation status of blastocysts were evaluated. Antioxidant treatment dur

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17

Patel, Bhakti, Huiyuan Zhang, Malgorzata A. Zal, Xianxiu Wan, Tomasz Zal, and Stephanie S. Watowich. "STAT3 modulates metabolic programming of inflammation-induced macrophages." Journal of Immunology 204, no. 1_Supplement (2020): 144.22. http://dx.doi.org/10.4049/jimmunol.204.supp.144.22.

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Abstract Redox homeostasis in an inflammatory environment is crucial to ensure a balanced immune response. Several inflammatory disorders are associated with impairment of redox homeostasis, leading to DNA damage and subsequent immune dysregulation. The transcription factor STAT3 has anti-inflammatory activity in myeloid cells, mediated by inhibition of Ubc13, a key Toll-like receptor (TLR) signaling component. STAT3 anti-inflammatory activity is crucial in protection from systemic inflammation, maintenance of lineage-balanced hematopoiesis, and inhibition of DNA damage accumulation in hematop

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18

Caple, Fiona, Elizabeth A. Williams, Alison Spiers, et al. "Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype." British Journal of Nutrition 103, no. 11 (2010): 1585–93. http://dx.doi.org/10.1017/s0007114509993540.

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Diets rich in fruits and vegetables are associated with lower risk of cancer which may be conferred in part by the antioxidant properties of these foods. However, antioxidant supplementation or increased consumption of antioxidant-rich foods has been reported to have inconsistent effects on DNA damage. The present work (the DART study) investigated the extent of inter-individual variation in DNA damage, the capacity for base excision repair (BER) and the responses of both variables to supplementation with an antioxidant supplement for 6 weeks. There was a wide inter-individual variation in end

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Pini, Taylor, Rachel Makloski, Karen Maruniak, William B. Schoolcraft, and Mandy G. Katz-Jaffe. "Mitigating the Effects of Oxidative Sperm DNA Damage." Antioxidants 9, no. 7 (2020): 589. http://dx.doi.org/10.3390/antiox9070589.

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Sperm DNA damage is correlated with reduced embryo development and increased miscarriage risk, reducing successful conception. Given its links with oxidative stress, antioxidants have been investigated as a potential treatment, yet results are conflicting. Importantly, individual antioxidants are not identical in composition, and some compounds may be more effective than others. We investigated the use of the polyphenol-rich, high-antioxidant-capacity fruit acai as a treatment for elevated sperm DNA fragmentation (>16%), measured by terminal deoxynucleotidyl transferase dUTP nick end labell

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Hassain Enayah, Sabah, Ahmed K. Al Atya, and Afrah A. Maktoof. "The protective role of N-Acetyl Cysteine and vitamin C against atrazine-Induced Dopaminergic Neurodegeneration in N27 Cells." University of Thi-Qar Journal of Science 6, no. 4 (2018): 54–61. http://dx.doi.org/10.32792/utq/utjsci/v6i4.67.

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Background: Atrazine (ATZ)has been associated with its capability to interact and damage DNA in neuronal cells. However, the molecular mechanisms of ATZ are not fully understood. In vitro and In vivo studies indicated that atrazine induces cytotoxicity and oxidative stress in human and animals. This study sought to determine the role of two antioxidants against the toxic impact of atrazine. Main Methods: N27 cell line pretreated to N-acetyl Cysteine NAC or Ascorbic acid AA alone or in combination before 24h atrazine exposure. Multiple intercellular antioxidant parameters measured such as (GSH,

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Kapralova, Katarina, Ondrej Jahoda, Pavla Koralkova, et al. "Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia." International Journal of Molecular Sciences 21, no. 24 (2020): 9652. http://dx.doi.org/10.3390/ijms21249652.

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Molecular pathophysiology of Diamond-Blackfan anemia (DBA) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis; with the activation of p53 considered as a key component. Recently, oxidative stress was proposed to play an important role in DBA pathophysiology as well. CRISPR/Cas9-created Rpl5- and Rps19-deficient murine erythroleukemia (MEL) cells and DBA patients’ samples were used to evaluate proinflammatory cytokines, oxidative stress, DNA damage and DNA damage response. We demonstrated that the antioxidant defense capacity of Rp-mutant cells is insufficient to

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Neubauer, Oliver, Stefanie Reichhold, Lukas Nics, et al. "Antioxidant responses to an acute ultra-endurance exercise: impact on DNA stability and indications for an increased need for nutritive antioxidants in the early recovery phase." British Journal of Nutrition 104, no. 8 (2010): 1129–38. http://dx.doi.org/10.1017/s0007114510001856.

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Antioxidant requirements have neither been defined for endurance nor been defined for ultra-endurance athletes. To verify whether an acute bout of ultra-endurance exercise modifies the need for nutritive antioxidants, we aimed (1) to investigate the changes of endogenous and exogenous antioxidants in response to an Ironman triathlon; (2) to particularise the relevance of antioxidant responses to the indices of oxidatively damaged blood lipids, blood cell compounds and lymphocyte DNA and (3) to examine whether potential time-points of increased susceptibility to oxidative damage are associated

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Guarnieri, Serena, Steffen Loft, Patrizia Riso, et al. "DNA repair phenotype and dietary antioxidant supplementation." British Journal of Nutrition 99, no. 5 (2008): 1018–24. http://dx.doi.org/10.1017/s0007114507842796.

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Phytochemicals may protect cellular DNA by direct antioxidant effect or modulation of the DNA repair activity. We investigated the repair activity towards oxidised DNA in human mononuclear blood cells (MNBC) in two placebo-controlled antioxidant intervention studies as follows: (1) well-nourished subjects who ingested 600 g fruits and vegetables, or tablets containing the equivalent amount of vitamins and minerals, for 24 d; (2) poorly nourished male smokers who ingested 500 mg vitamin C/d as slow- or plain-release formulations together with 182 mg vitamin E/d for 4 weeks. The mean baseline le

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Du, Wei, Reena Rani, Jared Sipple, et al. "The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters." Blood 119, no. 18 (2012): 4142–51. http://dx.doi.org/10.1182/blood-2011-09-381970.

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Abstract Oxidative stress has been implicated in the pathogenesis of many human diseases including Fanconi anemia (FA), a genetic disorder associated with BM failure and cancer. Here we show that major antioxidant defense genes are down-regulated in FA patients, and that gene down-regulation is selectively associated with increased oxidative DNA damage in the promoters of the antioxidant defense genes. Assessment of promoter activity and DNA damage repair kinetics shows that increased initial damage, rather than a reduced repair rate, contributes to the augmented oxidative DNA damage. Mechanis

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Ortiz-Franco, Manuel, Elena Planells, Bartholomé Quintero, et al. "Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes." International Journal of Sports Medicine 38, no. 14 (2017): 1117–25. http://dx.doi.org/10.1055/s-0043-119881.

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AbstractThe aim of the study was to evaluate the effect of melatonin supplementation on antioxidant capacity and DNA damage in high intensity interval training (HIIT) athletes. A 2-week randomised, double-blinded, placebo-controlled trial with two groups was conducted. Placebo (PG) and melatonin (MG) (20 mg/d) athletes were monitored over a two-week period of HIIT and strength training. The total antioxidant capacity (TAC) and the glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were analysed in blood samples. DNA damage was measured in isolated lymphocytes by comet assay

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Golla, Upendarrao, and Solomon Sunder Raj Bhimathati. "Evaluation of Antioxidant and DNA Damage Protection Activity of the Hydroalcoholic Extract ofDesmostachya bipinnataL. Stapf." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/215084.

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Desmostachya bipinnataStapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts of this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed to evaluate the antioxidant and DNA damage protection activity of hydroalcoholic extract ofDesmostachya bipinnatabothin vitroandin vivo, to provide scientific basis for traditional usage of this plant. The extract showed significant antioxidant activity in a dose-dependent manner with an IC50value of264.18±3.47 μg/mL in H2O2scavenging assay and prevented

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Jecika Stefany Br Tumanggor, Razoki Razoki, Muhammad Yunus, and Daimah Wirdatus Sanaun Harahap. "Uji Aktivitas Antioksidan Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) dengan Metode DPPH." Jurnal Ilmu Kedokteran dan Kesehatan Indonesia 5, no. 2 (2025): 241–48. https://doi.org/10.55606/jikki.v5i2.6142.

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Free radicals are reactive compounds that can cause damage to cells, enzymes, lipids, and even DNA, thus triggering various degenerative diseases. Antioxidants neutralize free radicals and prevent oxidative damage. Chinese betel herb (Peperomia pellucida L.) is known to contain phenol and flavonoid secondary metabolite compounds that act as natural antioxidants. This study aims to test the antioxidant activity of ethanol extract of Chinese betel herb with DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was done by maceration method using 80% ethanol solvent. Antioxidant activity was te

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Sun, Bolu, Yanmei Yang, Shixing Yu, et al. "Electrochemical Biosensor Based on ds-DNA/N-G@CS/GCE for Highly Sensitive and Rapid Measurement of Antioxidant Activity." ECS Advances 2, no. 2 (2023): 026501. http://dx.doi.org/10.1149/2754-2734/acd017.

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Antioxidants remove free radicals and inhibit the oxidation of oxygen-sensitive substances, which are of great significance in disease prevention and food preservative. Therefore, it is of great significance to establish a convenient, efficient and universal method for screening and evaluating antioxidant activity. In this study, Nitrogen-doped Graphene (N-G) with high conductivity and Chitosan (CS) with good film forming and stability were used as electrode substrate materials. And a ds-DNA/N-G@CS/GCE electrochemical biosensor for rapid evaluation of antioxidant activity was constructed by as

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Tsai, Yi-Chih, Pei-Yi Li, Chung-Chu Chen, and Yin-Chang Liu. "Is the Oxidative DNA Damage Level of Human Lymphocyte Correlated with the Antioxidant Capacity of Serum or the Base Excision Repair Activity of Lymphocyte?" Oxidative Medicine and Cellular Longevity 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/237583.

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A random screening of human blood samples from 24 individuals of nonsmoker was conducted to examine the correlation between the oxidative DNA damage level of lymphocytes and the antioxidant capacity of serum or the base excision repair (BER) activity of lymphocytes. The oxidative DNA damage level was measured with comet assay containing Fpg/Endo III cleavage, and the BER activity was estimated with a modified comet assay including nuclear extract of lymphocytes for enzymatic cleavage. Antioxidant capacity was determined with trolox equivalent antioxidant capacity assay. We found that though th

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Fox, Jennifer T., Srilatha Sakamuru, Ruili Huang, et al. "Reply to Kojo: Mechanisms of antioxidant-induced DNA damage." Proceedings of the National Academy of Sciences 109, no. 30 (2012): E2029. http://dx.doi.org/10.1073/pnas.1207795109.

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Selman, Colin, Jane S. McLaren, Andrew R. Collins, Garry G. Duthie, and John R. Speakman. "Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal." Biology Letters 9, no. 4 (2013): 20130432. http://dx.doi.org/10.1098/rsbl.2013.0432.

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While oxidative damage owing to reactive oxygen species (ROS) often increases with advancing age and is associated with many age-related diseases, its causative role in ageing is controversial. In particular, studies that have attempted to modulate ROS-induced damage, either upwards or downwards, using antioxidant or genetic approaches, generally do not show a predictable effect on lifespan. Here, we investigated whether dietary supplementation with either vitamin E (α-tocopherol) or vitamin C (ascorbic acid) affected oxidative damage and lifespan in short-tailed field voles, Microtus agrestis

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Xhuti, Donald, Irena A. Rebalka, Mahek Minhas, et al. "The Acute Effect of Multi-Ingredient Antioxidant Supplementation following Ionizing Radiation." Nutrients 15, no. 1 (2023): 207. http://dx.doi.org/10.3390/nu15010207.

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Radiation exposure is an undeniable health threat encountered in various occupations and procedures. High energy waves in ionizing radiation cause DNA damage and induce reactive oxygen species (ROS) production, which further exacerbate DNA, protein, and lipid damage, increasing risk of mutations. Although endogenous antioxidants such as superoxide dismutase have evolved to upregulate and neutralize ROS, exogenous dietary antioxidants also have the potential to combat ionizing radiation (IR)-induced ROS production. We evaluated a cocktail of ingredients (AOX) purported to have antioxidant and m

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Williamson, Josh, and Gareth Davison. "Targeted Antioxidants in Exercise-Induced Mitochondrial Oxidative Stress: Emphasis on DNA Damage." Antioxidants 9, no. 11 (2020): 1142. http://dx.doi.org/10.3390/antiox9111142.

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Exercise simultaneously incites beneficial (e.g., signal) and harming (e.g., damage to macromolecules) effects, likely through the generation of reactive oxygen and nitrogen species (RONS) and downstream changes to redox homeostasis. Given the link between nuclear DNA damage and human longevity/pathology, research attempting to modulate DNA damage and restore redox homeostasis through non-selective pleiotropic antioxidants has yielded mixed results. Furthermore, until recently the role of oxidative modifications to mitochondrial DNA (mtDNA) in the context of exercising humans has largely been

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Merlin, J. P. Jose, Graham Dellaire, Kieran Murphy, and H. P. Vasantha Rupasinghe. "Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro." Biomedicines 9, no. 11 (2021): 1665. http://dx.doi.org/10.3390/biomedicines9111665.

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Lung cancer has the highest mortality rate worldwide and is often diagnosed at late stages, requiring genotoxic chemotherapy with significant side effects. Cancer prevention has become a major focus, including the use of dietary and supplemental antioxidants. Thus, we investigated the ability of an antioxidant formulation (AOX1) to reduce DNA damage in human bronchial epithelial cells (BEAS-2B) with and without the combination of apple peel flavonoid fraction (AF4), or its major constituent quercetin (Q), or Q-3-O-d-glucoside (Q3G) in vitro. To model smoke-related genotoxicity, we used cigaret

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Catalán, Jaime, Iván Yánez-Ortiz, Marc Torres-Garrido, et al. "Impact of Seminal Plasma Antioxidants on DNA Fragmentation and Lipid Peroxidation of Frozen–Thawed Horse Sperm." Antioxidants 13, no. 3 (2024): 322. http://dx.doi.org/10.3390/antiox13030322.

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Cryopreservation is a stressful process for sperm, as it is associated with an increased production of reactive oxygen species (ROS). Elevated ROS levels, which create an imbalance with antioxidant capacity, may result in membrane lipid peroxidation (LPO), protein damage and DNA fragmentation. This study aimed to determine whether the membrane LPO and DNA fragmentation of frozen–thawed horse sperm relies upon antioxidant activity, including enzymes (superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and paraoxonase type 1 (PON1)); non-enzymatic antioxidant capacity (Trolo

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Nermien, Z. Ahmed, and R. Ibrahim Shaimaa. "Cardio-protective Effect of Selenium and Lemon Grass (Cymbopogon citratus) Ethanolic Extract against Doxorubicin-induced Cardio Toxicity and DNA Fragmentation in Rats." Pharmaceutical and Chemical Journal 5, no. 1 (2018): 96–116. https://doi.org/10.5281/zenodo.13891395.

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Doxorubicin (Dox) is a chemotherapy drug used for treatment of wide variety of cancers and the most effective antitumor agents, soon proved to be hampered by such serious problems as the development of cardiotoxicity and heart damage by producing free radicals and oxidative stress along the period of treatment. The current study aims at evaluating the cardio protective effect of <em>Cymbopogon citrates</em> known as lemon grass (LG) and the role of trace element selenium (SE), which is an essential element possessing antioxidant properties and has protective effects against toxicity of some dr

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Godic, Aleksandar, Borut Poljšak, Metka Adamic, and Raja Dahmane. "The Role of Antioxidants in Skin Cancer Prevention and Treatment." Oxidative Medicine and Cellular Longevity 2014 (March 26, 2014): 1–6. http://dx.doi.org/10.1155/2014/860479.

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Skin cells are constantly exposed to reactive oxygen species (ROS) and oxidative stress from exogenous and endogenous sources. UV radiation is the most important environmental factor in the development of skin cancer and skin aging. The primary products caused by UV exposure are generally direct DNA oxidation or generation of free radicals which form and decompose extremely quickly but can produce effects that can last for hours, days, or even years. UV-induced generation of ROS in the skin develops oxidative stress when their formation exceeds the antioxidant defense ability. The reduction of

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KoŠíková, Božena, Juraj Lábaj, Adriána Gregorová, and Darina Slameňová. "Lignin antioxidants for preventing oxidation damage of DNA and for stabilizing polymeric composites." Holzforschung 60, no. 2 (2006): 166–70. http://dx.doi.org/10.1515/hf.2006.027.

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Abstract The antioxidative behavior of various lignin preparations derived from chemical wood treatment for paper production was examined. All lignin samples exhibited higher antioxidant activity than Trolox. The protective effect of lignin antioxidants against H2O2-induced oxidative damage of DNA in human carcinoma cells and male rats was evaluated. Moreover, lignin was tested as a stabilizer in the processing of polypropylene composites, as well as in thermo-oxidative aging of styrene-butadiene vulcanizates. The results indicate that the lignin preparations show great potential as antioxidan

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Younis, M. A., S. M. Ali, and A. S. Alchalabi. "Correlations among oxidative DNA damage markers, enzymatic antioxidants and HSPs in stressed rats with H2O2 at different concentrations." Regulatory Mechanisms in Biosystems 15, no. 4 (2024): 951–56. https://doi.org/10.15421/0224139.

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Oxidative stress is a normal metabolic byproduct and when produced in abnormal amounts it leads to cellular damage indicated by oxidative DNA damage and antioxidant enzyme reduction. The present study aimed to identify the mechanism by which DNA is destroyed. Blood samples were taken from rats exposed to oral 1% and 2% hydrogen peroxide and from the control group. RNA was extracted from blood, and transcription to cDNA synthesis was done. Primers for heat shock proteins and antioxidant enzymes were designed, PCR was conducted, and serum was analysed for 8-hydroxydeoxyguanosine and tumor protei

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YILDIZ, Hülya. "Effects of glutathione on mitochondrial DNA and antioxidant enzyme activities in Drosophila melanogaster." International Journal of Secondary Metabolite 9, no. 4 (2022): 377–86. http://dx.doi.org/10.21448/ijsm.1084592.

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The free radical theory in aging assumes that the accumulation of macromolecular damage induced by toxic reactive oxygen species plays a central role in the aging process. The intake of nutritional antioxidants can prevent this damage by neutralizing reactive oxygen derivatives. Glutathione (GSH; en-L-Glutamyl-L-cysteinyl glycine) is the lowest molecular weight thiol in the cells and as a cofactor of many enzymes and a potent antioxidant plays an important role in maintaining normal cell functions by destroying toxic oxygen radicals. In this study, the effects of GSH on SOD, GST and catalase e

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Zorić, Nataša, Nevenka Kopjar, Jadranka Vuković Rodriguez, Siniša Tomić, and Ivan Kosalec. "Protective effects of olive oil phenolics oleuropein and hydroxytyrosol against hydrogen peroxide-induced DNA damage in human peripheral lymphocytes." Acta Pharmaceutica 71, no. 1 (2021): 131–41. http://dx.doi.org/10.2478/acph-2021-0003.

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AbstractThis study investigates antioxidant capacity and protective effects of phenolic compounds oleuropein (OLP) and hydroxytyrosol (HT), present in olive oil and olive leaves, against H2O2-induced DNA damage in human peripheral lymphocytes. Antioxidant potency was determined using the measurement of radical-scavenging activity (ABTS∙+ assay), ferric reducing power (FRAP assay) and cupric reducing antioxidant capacity (CUPRAC assay). Both substances were found to be potent antioxidant agents due to their free radical-scavenging activities. Antigenotoxic effects of oleuropein and hydroxytyros

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Garcia-Mouronte, Emilio, Luis Alfonso Pérez-González, Jorge Naharro-Rodriguez, and Montserrat Fernández Guarino. "Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants." Life 14, no. 7 (2024): 822. http://dx.doi.org/10.3390/life14070822.

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The detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis. Conventional photoprotective measures predominantly rely on filters, which scatter or absorb UV radiation, yet fail to address the cellular damage incurred post-exposure. To fill this gap, antioxidant molecules and DNA–repair enzymes have been extensively researched, offering a paradigm shift towards active photoprotection capable of both preventing and reversing UV–induced damage. In the current review, we focused on “act

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Nayan, Nazatul Shima, Muhammad Aiman Mohd Yazid, Kamachisree Nallappan, et al. "In Vitro Modulation of Endogenous Antioxidant Enzyme Activities and Oxidative Stress in Autism Lymphoblastoid Cell Line (ALCL) by Stingless Bee Honey Treatment." Oxidative Medicine and Cellular Longevity 2020 (December 1, 2020): 1–7. http://dx.doi.org/10.1155/2020/4539891.

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Autism has been associated with a low antioxidant defense mechanism, while honey has been known for decades for its antioxidant and healing properties. Determination of stingless bee honey (KH) effects on antioxidant enzyme activities and oxidative damage in Autism Lymphoblastoid Cell Line (ALCL) was performed. ALCL and its normal sibling pair (NALCL) were cultured in RPMI-1640 medium at 37°C and 5% CO2. ALCL was treated with 400 μg/mL KH (24 h), and oxidative stress marker, malondialdehyde (MDA), and antioxidant enzyme activities (catalase (CAT), glutathione peroxidase (GPx), and superoxide d

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Sreekumar, R., J. Unnikrishnan, A. Fu, et al. "Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle." American Journal of Physiology-Endocrinology and Metabolism 282, no. 5 (2002): E1055—E1061. http://dx.doi.org/10.1152/ajpendo.00554.2001.

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High-fat diets are reported to increase oxidative stress in a variety of tissues, whereas antioxidant supplementation prevents many diseases attributed to high-fat diet. Rodent skeletal muscle mitochondrial DNA has been shown to be a potential site of oxidative damage. We hypothesized that the effects of a high-fat diet on skeletal muscle DNA functions would be attenuated or partially reversed by antioxidant supplementation. Gene expression profiling and measurement of mitochondrial ATP production capacity were performed in skeletal muscle from male rats after feeding one of three diets (contr

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Menéndez-Perdomo, Ivette M., Maylin Wong-Guerra, Fabiana Fuentes-León, et al. "Antioxidant, photoprotective and antimutagenic properties of Phyllanthus spp. from Cuban flora." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 251–61. http://dx.doi.org/10.56499/jppres17.212_5.4.251.

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Context: Sunlight ultraviolet (UV) radiation constitutes a significant physical carcinogen in nature. It could induce direct and indirect DNA damage, which if not properly repaired may generate mutations. Plants in the genus Phyllanthus (Phyllanthaceae) are widely used in traditional medicine and known as natural sources of antioxidant compounds. Recent investigations support their genoprotective activity against chemical and physical mutagens, among them UV radiation. Aims: To compare the antioxidant, photoprotective and antimutagenic activity of aqueous extracts obtained from three Cuban end

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Rajesh, Kowti, Joshi Vedamurthy, Kumar Mani Rupesh, et al. "UV rays induced DNA damage: Protection by polyphenols enriched extract of mint leaves." World Journal of Advanced Research and Reviews 8, no. 2 (2020): 152–57. https://doi.org/10.5281/zenodo.4318600.

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DNA of live cells is damaged when exposed to harmful Ultraviolet rays.  If the cells are exposed to UV rays exposure time more duration of time, more thymine dimers are formed in the DNA and the greater the risk of an incorrect repair or a missed dimer.  To analyze the effect of UV rays Calf thymus DNA and prevention by polyphenol enriched extract of Mint leaves and also its non toxic nature. The above study was done by using submarine gel electrophoresis where UV rays are used to damage the DNA and BHA (400µM) used as positive control.   The polyphenol enriched extra

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Korolev, V. A., A. V. Sedykh, E. V. Felker, I. V. Korolev, V. A. Ryadnova, and E. V. Korolev. "Assessment of the redox potential and DNA oxidative damage (8-OHdG) in subchronic thiram intoxication." Theoretical and Applied Ecology, no. 2 (June 25, 2025): 183–89. https://doi.org/10.25750/1995-4301-2025-2-183-189.

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In this study the effect of oxidative stress caused by subchronic intoxication with the fungicide thiram on the antioxidant defense system of the body was examined and the methods for correcting the antioxidant status were developed. As a result of the introduction of thiram, there was a significant increase in the amount of reactive oxygen species (ROS) (~ 3.26 times in relation to the control), together with a significant decrease in reduced glutathione (GSH) (~ 2.63 times) and total antioxidant activity (AAA) (~ 1.64 times) in blood plasma. The level of 8-oxo-2’-deoxyguanosine (8-OHdG) was

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Verle, Olga, Oleg Ostrovskiy, Valerian Verovskiy, and Galina Dudchenko. "Estimation of the Genotoxicityof Hydrogen Peroxide and Antioxidant Actionof Halo Acid by the Method of Dna-Cometwith the Use of the Model of Transplantable Cell Cultures." Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Serija 11. Estestvennye nauki, no. 1 (August 2018): 40–43. http://dx.doi.org/10.15688/jvolsu11.2018.1.7.

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In the framework of the study, the degree of defragmentation of DNA by the DNA-comet method is evaluated when exposed to the cell culture of hydrogen peroxide (H2O2), and an in vitro model is developed to evaluate the antioxidant activity of new pharmacological agents. The results of working with cell lines show that the percentage of damage to the genetic material of cells of intact samples does not greatly vary from the method of removing the cellular monolayer from the culture plastic. Concerning the effect of H2O2 as an inducer of oxidative stress on DNA cell damage, the optimal level of D

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Daré, Regina G., and Sueli O. S. Lautenschlager. "Nanoparticles with Antioxidant Activity." Antioxidants 14, no. 2 (2025): 221. https://doi.org/10.3390/antiox14020221.

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Oxidative stress is commonly defined as an imbalance between reactive oxygen species (ROS) production and an organism’s ability to neutralize them via antioxidant defense mechanisms, leading to damage to biomolecules, including lipids, proteins, and DNA [...]

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Ménézo, Yves, Frida Entezami, Isabelle Lichtblau, Stephanie Belloc, Marc Cohen, and Brian Dale. "Oxidative stress and fertility: incorrect assumptions and ineffective solutions?" Zygote 22, no. 1 (2012): 80–90. http://dx.doi.org/10.1017/s0967199412000263.

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SummaryOne of the most important concerns in assisted reproduction (ART), and in particular ICSI, is the quality of sperm DNA. Oxidative stress is one of the major causes of damage to DNA and attempting to reduce generation of DNA damage related to reactive oxygen species (ROS) through consumption of antioxidants is often tempting. However, current antioxidant treatments, given irrespectively of clinically quantified deficiencies, are poorly efficient, potentially detrimental and over-exposure is risky. Here we discuss new treatments in relation to present day concepts on oxidative stress. Thi

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