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Relevant bibliographies by topics / Antisense nucleic acids

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Academic literature on the topic 'Antisense nucleic acids'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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Journal articles on the topic "Antisense nucleic acids"

1

Goodchild, John. "Antisense nucleic acids and proteins." Cell Biophysics 18, no. 3 (June 1991): 295–96. http://dx.doi.org/10.1007/bf02989820.

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Razzak, Mina. "Antisense nucleic acids—tough delivery." Nature Reviews Urology 10, no. 12 (November 19, 2013): 681. http://dx.doi.org/10.1038/nrurol.2013.271.

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3

Penchovsky, Robert, Antoniya V. Georgieva, Vanya Dyakova, Martina Traykovska, and Nikolet Pavlova. "Antisense and Functional Nucleic Acids in Rational Drug Development." Antibiotics 13, no. 3 (February 27, 2024): 221. http://dx.doi.org/10.3390/antibiotics13030221.

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This review is focused on antisense and functional nucleic acid used for completely rational drug design and drug target assessment, aiming to reduce the time and money spent and increase the successful rate of drug development. Nucleic acids have unique properties that play two essential roles in drug development as drug targets and as drugs. Drug targets can be messenger, ribosomal, non-coding RNAs, ribozymes, riboswitches, and other RNAs. Furthermore, various antisense and functional nucleic acids can be valuable tools in drug discovery. Many mechanisms for RNA-based control of gene express

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4

Soomets, Ursel. "Antisense properties of peptide nucleic acids." Frontiers in Bioscience 4, no. 1-3 (1999): d782. http://dx.doi.org/10.2741/soomets.

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Langel, Ülo. "Antisense properties of peptide nucleic acids." Frontiers in Bioscience 4, no. 4 (1999): d782–786. http://dx.doi.org/10.2741/a394.

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6

Tonkinson, J. L., and C. A. Stein. "Antisense Nucleic Acids — Prospects for Antiviral Intervention." Antiviral Chemistry and Chemotherapy 4, no. 4 (August 1993): 193–200. http://dx.doi.org/10.1177/095632029300400401.

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Antisense oligodeoxynucleotides are a promising new class of antiviral agent. Because they bind in a sequence-specific manner to complementary regions of mRNA, oligos can inhibit gene expression in a sequence-specific manner. The ‘antisense’ approach has been used successfully to block cellular expression and replication of several viruses including Human Immunodeficiency Virus-1 (HIV-1), and Herpes Simplex Virus (HSV). However, the antiviral effect of oligodeoxynucleotides is not limited to sequence-specific inhibition of gene expression. Non sequence-specific effects are frequently observed,

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Morihiro, Kunihiko, Yuuya Kasahara, and Satoshi Obika. "Biological applications of xeno nucleic acids." Molecular BioSystems 13, no. 2 (2017): 235–45. http://dx.doi.org/10.1039/c6mb00538a.

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Malcolm, Alan D. B. "Uses of antisense nucleic acids — an introduction." Biochemical Society Transactions 20, no. 4 (November 1, 1992): 745–46. http://dx.doi.org/10.1042/bst0200745.

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9

Flores, Maria Vega C., David Atkins, Thomas Stanley Stewart, Arthur van Aerschot, and Piet Herdewijn. "Antimalarial antisense activity of hexitol nucleic acids." Parasitology Research 85, no. 10 (August 24, 1999): 864–66. http://dx.doi.org/10.1007/s004360050647.

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Nielsen, Peter. "Targeting structured nucleic acids with antisense agents ▾." Drug Discovery Today 8, no. 10 (May 2003): 440. http://dx.doi.org/10.1016/s1359-6446(03)02702-8.

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Dissertations / Theses on the topic "Antisense nucleic acids"

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Abbas, Sahar. "Design and synthesis of backbone-modified nucleic acids." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368273.

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Bijapur, Jeevan. "Factors affecting the stability of nucleic acids." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299497.

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Slaitas, Andis. "Development of a new PNA analogue as a potential antisense drug and tool for life-science studies /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-642-1/.

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Dryselius, Rikard. "Bacterial gene expression inhibition with antisense peptide nucleic acids /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-338-8/.

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Dysko, Anna Monika. "Synthesis and properties of oligonucleotides containing triazole backbone linkages and 2'-modifications for therapeutic applications." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:20fc1203-9751-4654-b497-5f4d97f874a1.

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Antisense oligonucleotides are short strands of DNA, which bind to their complementary mRNA target to prevent protein translation. Although conceptually appealing, for their practical use as drugs, these oligonucleotides must have better cellular uptake, resistance to enzymatic degradation, and target selectivity. In this work, new synthetic chemistry is established to prepare a novel group of chemically modified oligonucleotides. The anionic phosphodiester backbone is partially replaced with a neutral triazole and, at the same time, the 2'-position of the ribose sugar is functionalised with p

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Lewis, Karen Jane. "Biodegradable polymers for the sustained release of antisense nucleic acids." Thesis, Aston University, 1996. http://publications.aston.ac.uk/11054/.

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Antisense oligodeoxynucleotides can selectively inhibit individual gene expression provided they remain stable at the target site for a sufficient period of time. Thus, the efficacy of antisense oligodeoxynucleotides may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for the oligodeoxynucleotides and ribozymes. Polymers such as polylactide, polyglycolide, polyhydroxybutyr

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Dong, Shuzhi Dong Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4' II. Studies toward the enantioselective synthesis of pestalotiopsin A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174627553.

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Silvester, Nicole Cherie. "Terminal Modifications of PNA and Their Use in Diagnostic and Antisense Technologies." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/366991.

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Peptide nucleic acids (PNA) are analogues of DNA that bind to DNA and RNA via Watson-Crick base-pairing rules. Due to the lack of a negatively-charged backbone, hybridisation of PNA to DNA or RNA occurs without electrostatic repulsion thus binding is typically stronger and more rapid than when traditional DNA probes are used. This is reflected in the increased melting temperature (Tm) of the conjugates. These properties, as well as the chemical and biological stability of PNA, make these molecules attractive for use in diagnostic and therapeutic applications. Amino acids are routinely conjugat

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Xu, Jian, and 徐堅. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220150.

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Xu, Jian. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19918884.

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Books on the topic "Antisense nucleic acids"

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1947-, Brakel Christine L., ed. Discoveries in antisense nucleic acids. The Woodlands, Tex: Portfolio Pub. Co., 1989.

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2

A, Stein Cy, and Krieg Arthur M, eds. Applied antisense oligonucleotide technology. New York: Wiley-Liss, 1998.

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3

Ian, Phillips M., ed. Antisense therapeutics. 2nd ed. Totowa, N.J: Humana Press, 2005.

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Ian, Phillips M., ed. Antisense therapeutics. 2nd ed. Totowa, N.J: Humana Press, 2005.

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5

1966-, Hartmann Gunther, and Endres Stefan 1957-, eds. Manual of antisense methodology. Boston: Klwuer Academic, 1999.

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6

Renato, Baserga, and Denhardt David T, eds. Antisense strategies. New York: New York Academy of Sciences, 1992.

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7

T, Crooke Stanley, ed. Antisense drug technology: Principles, strategies, and applications. 2nd ed. Boca Raton: Taylor & Francis, 2006.

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8

Sudhir, Agrawal, ed. Antisense therapeutics. Totowa, N.J: Humana Press, 1996.

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9

Mol, Joseph N. M., 1948- and Krol, Alexander R. van der, 1956-, eds. Antisense nucleic acids and proteins: Fundamentals and applications. New York: M. Dekker, 1991.

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10

Ian, Phillips M., ed. Antisense technology: General methods, methods of delivery and RNA studies. San Diego, CA: Academic Press, 1999.

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Book chapters on the topic "Antisense nucleic acids"

1

Houba-Hérin, N., and M. Inouye. "Antisense RNA." In Nucleic Acids and Molecular Biology, 210–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-46596-3_13.

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2

Goh, Shan, Jem Stach, and Liam Good. "Antisense Effects of PNAs in Bacteria." In Peptide Nucleic Acids, 223–36. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-553-8_18.

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Goltermann, Lise, and Peter E. Nielsen. "PNA Antisense Targeting in Bacteria: Determination of Antibacterial Activity (MIC) of PNA-Peptide Conjugates." In Peptide Nucleic Acids, 231–39. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0243-0_14.

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4

Liang, Xue-hai, Timothy A. Vickers, and Stanley T. Crooke. "Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs." In From Nucleic Acids Sequences to Molecular Medicine, 191–214. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_8.

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Eritja, Ramon, Montserrat Terrazas, Santiago Grijalvo, Anna Aviñó, Adele Alagia, Sónia Pérez-Rentero, and Juan Carlos Morales. "Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms." In Chemical Biology of Nucleic Acids, 227–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54452-1_13.

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6

Magistri, Marco, and Mohammad Ali Faghihi. "Natural Antisense Transcripts Mediate Regulation of Gene Expression." In From Nucleic Acids Sequences to Molecular Medicine, 247–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_10.

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7

Caruso, Gerardo, Mariella Caffo, Giuseppe Raudino, Federica Raudino, Mario Venza, and Francesco Tomasello. "Antisense Oligonucleotides in the Treatment of Malignant Gliomas." In From Nucleic Acids Sequences to Molecular Medicine, 215–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_9.

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Gait, Michael J., and Sudhir Agrawal. "Introduction and History of the Chemistry of Nucleic Acids Therapeutics." In Methods in Molecular Biology, 3–31. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_1.

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AbstractThis introduction charts the history of the development of the major chemical modifications that have influenced the development of nucleic acids therapeutics focusing in particular on antisense oligonucleotide analogues carrying modifications in the backbone and sugar. Brief mention is made of siRNA development and other applications that have by and large utilized the same modifications. We also point out the pitfalls of the use of nucleic acids as drugs, such as their unwanted interactions with pattern recognition receptors, which can be mitigated by chemical modification or used as immunotherapeutic agents.

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Di Cresce, Christine, Colin Way, Mateusz Rytelewski, Saman Maleki Vareki, Supritha Nilam, Mark D. Vincent, James Koropatnick, and Peter J. Ferguson. "Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments." In From Nucleic Acids Sequences to Molecular Medicine, 145–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_7.

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Stetsenko, Dmitry A. "Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents." In Handbook of Chemical Biology of Nucleic Acids, 1–41. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-1313-5_19-1.

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Conference papers on the topic "Antisense nucleic acids"

1

Van Aerschot, Arthur, Mark Vandermeeren, Johan Geysen, Walter Luyten, Marc Miller, David Atkins, Sonia Preveral, Ester Saison-Behmoaras, and Piet Herdewijn. "In vitro evaluation of hexitol nucleic acid antisense oligonucleotides." In XIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902151.

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Marzenell, Paul D., Helen Hagen, Larisa Kovbasyuk, and Andriy Mokhir. "Chemically modified phosphorothioate DNA and 2'-OMe RNA as antisense agents." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112391.

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Wojtczak, Blazej A., Agnieszka Andrysiak, and Zbigniew J. Lesnikowski. "An approach towards synthesis of antisense oligonucleotides modified with lipophilic boron clusters via "click chemistry" method." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810482.

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Ravn, Jacob, Maj Hedtjärn, Niels Fisker, Joachim Elmén, Marie W. Lindblom, Henrik F. Hansen, Michael Meldgaard, Ellen M. Straarup, Jens B. Hansen та Christoph Rosenbohm. "Locked nucleic acid antisense oligonucleotides targeting apolipoprotein B: the effect of short sequences and α-L-LNA insertion". У XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112444.

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Greco, Francesca, Elena Cesaro, Andrea Falanga, Rosa Catapano, Simona Romano, Nicola Borbone, Arianna Pastore, et al. "A novel antisense strategy peptide nucleic acid-based to downregulate CD5 expression in chronic lymphocytic leukemia." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11396.

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Levin, Arthur A., Lee M. Greenberger, Aby Buchbinder, Bo R. Hansen, Maj Hedtjärn, Sakari Kauppinen, Henrik Oerum, and Ivan D. Horak. "Abstract SY31-02: Locked nucleic acid (LNA)-modified antisense oligonucleotides as anticancer agents: Using high-affinity antisense molecules in the laboratory and in the clinic." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-sy31-02.

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Brown, Paige K., Ammar T. Qureshi, Daniel J. Hayes, and W. Todd Monroe. "Targeted Gene Silencing With Light and a Silver Nanoparticle Antisense Delivery System." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53647.

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Targeted delivery and controlled release of oligonucleotide therapeutics in vivo are essential aspects of an ideal delivery vehicle. Here we demonstrate the synthesis and in vitro/intracellular characterization of silver nanoparticle (SNP) photolabile nucleic acid conjugates, with the aim of developing a nanoparticulate platform for inducible gene silencing. Due to unique size related properties, nanostructures are being increasingly utilized for intracellular diagnostics and delivery applications. While most nanoscale delivery platforms are polymeric in composition, studies of metallic nanopa

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Thomas, Sufi M., Shrinivas Rapiredd, Bichismita Sahu, Sonali Joyce, and Danith Ly. "Abstract C175: Antisense EGFR guanidium‐based peptide nucleic acid (GPNA) oligomers as an antitumor agent for head and neck cancer." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c175.

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Klar, Richard, Clara Seger, Nicole Kirchhammer, André Maaske, Julia Festag, Laura Fernandez Rodriguez, Mélanie Buchi, et al. "434 Targeting the expression of Neuropilin-1 by locked nucleic acid modified antisense oligonucleotides results in potent anti-tumor activity in vivo." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0434.

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Sapra, Puja, Yixian Zhang, Stephen Castaneda, Steven Kim, Patricia Kraft, Raj Bandaru, Lee M. Greenberger, and Ivan D. Horak. "Abstract C144: A locked nucleic acid antisense oligonucleotode against androgen receptor, down‐modulates target mRNA and causes antitumor effects in xenograft models of prostate cancer." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c144.

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