Relevant bibliographies by topics / Antisickling activity

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  2. Dissertations / Theses

Academic literature on the topic 'Antisickling activity'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Antisickling activity"

1

Adesanya, S., T. Idowu, and A. Elujoba. "Antisickling Activity ofAdansonia digitata." Planta Medica 54, no. 04 (1988): 374. http://dx.doi.org/10.1055/s-2006-962472.

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2

Alaribe, Chinwe S., Akolade R. Oladipupo, Naomi U. Kanu, and Luca Rastrelli. "In vitro Antioxidant Activity of a Nigerian Propolis and Its Investigation on Sickle Red Blood Cells." Ethiopian Pharmaceutical Journal 36, no. 1 (2020): 61–66. http://dx.doi.org/10.4314/epj.v36i1.7.

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Scientific evidence suggests that antioxidants could reduce the risk of chronic diseases, including cancer and cardiovascular diseases, and play an important role in general wellbeing. Sickle cell disease (SCD) is a debilitating monogenic disorder considered as a public health problem in many countries, but with a major burden in Sub-Saharan Africa. The use of antioxidants could prove relevant and beneficial in the treatment of SCD. In this study, the antioxidant and antisickling activities of methanol extract of a Nigerian propolis were investigated. Antioxidant activity was evaluated by scav
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3

Olomola, Temitope O., Tawakalit O. Kelani, Mojisola C. Cyril-Olutayo, and Joseph M. Agbedahunsi. "Evaluation of Some Salicylaldehyde-derived Baylis-Hillman Adducts and Coumarin Derivatives as Potential Antisickling Compounds." Annals of Science and Technology 3, no. 1 (2018): 35–42. http://dx.doi.org/10.2478/ast-2018-0013.

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AbstractSome salicylaldehyde-derived Baylis-Hillman adducts and 3-(chloromethyl)coumarins have been synthesised and evaluated in vitro for their antisickling activities. The compounds were screened for inhibitory and reversal activity against mutated haemoglobin (HbSS) in red blood cells at four different concentrations (4 mg/mL, 2 mg/mL, 1 mg/mL and 0.5 mg/mL) as a measure of their antisickling potentials. Among the synthesized compounds, 6-chloro-3-(chloromethyl)coumarin 4d showed the highest inhibitory activity (83.75±1.90%), followed by 6-chlorocoumarin-3-methylsulfinic acid 5d (80.90 ±0.9
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4

Atabo, Samuel, Ismaila Alhaji Umar, Dorcas Bolanle James, and Aisha Indo Mamman. "Sickled Erythrocytes Reversal and Membrane Stabilizing Compounds inTelfairia occidentalis." Scientifica 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/1568061.

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Background and Purpose. Traditional management of sickle cell disease (SCD) is ubiquitous in Africa. In south-eastern Nigeria,Telfairia occidentalis (T. occidentalis)is strongly recommended for consumption by SCD patients, owing to its presumed therapeutic effect. This study investigates the antisickling and membrane regenerative potentials ofT. occidentalisin sickled erythrocytes.Experimental Approach. Sickled erythrocytes obtained from SCD patients were treated with sodium metabisulphite (2%) to induce further sickling. Heat and hypotonic-induced lyses of red blood cells’ membranes were also
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5

Ngunde-te-Ngunde, Samy, Emmanuel Moke Lengbiye, Tshidibi Dipa Joseph, et al. "Antisickling and Antibacterial Activities of Anthocleista schweinfurthii Gilg. (Gentianaceae) from Non-human Primates Pharmacopoeia in Democratic Republic of the Congo." Budapest International Research in Exact Sciences (BirEx) Journal 1, no. 3 (2019): 14–20. http://dx.doi.org/10.33258/birex.v1i3.345.

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The aim of the present study was to evaluate the Chemical composition and bioactivity of Anthocleista schweinfurthii Gilg (Gentianaceae) fruits, leaves, root bark and stem bark extracts against Sickle cell disease (SCD) and associated bacteria. The antisickling and antibacterial activities were carried out using Emmel and micro-dilution methods respectively. The results revealed that the fruits, leaves, root bark and stem bark extracts of A. schweinfurthii contains various secondary metabolites such as the alkaloids, saponins, total polyphenols, flavonoids, tannins, anthocyanis, leuco-anthocya
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6

Adebayo, EM, AA Adeyemi, OO Omotade, et al. "Antisickling Activity of the Fresh and Dried Roots of Cissus populnea Guill. Et Perr (Vitaceae)." Nigerian Journal of Natural Products and Medicine 19 (August 31, 2015): 134–38. http://dx.doi.org/10.4314/njnpm.v19i0.16.

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Research into plants with claimed traditional use in the management of sickle cell anaemia constitutes a useful research strategy in the search for new antisickling drugs and templates. The root of Cissus populnea has been used traditionally in the management of sickle cell disease (SCD). Phytochemical screening of the fresh and powdered sample of the root of C. populnea (CP) was done using standard methods followed by in vitro antisickling evaluation of extracts, solvent-partitioned fraction (ethylacetate) and the vacuum liquid chromatographic fractions (VLC) of the fresh and dried roots of C
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7

Floriane, Tammo, Cabral Biapa Nya Prosper, Juenkou Tekumu Jesse, et al. "In vitro Antisickling properties, Free radicals quenching potential, protective properties against oxidative mediated ion toxicity of combinations of Theobroma cocoa beans (sterculaceae)." Algerian Journal of Natural Products 7, no. 2 (2019): 685–700. https://doi.org/10.5281/zenodo.3549015.

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Sickle cell anaemia induces an abnormal haemoglobin synthesis and reactive oxygen species. The present work aims to determine the antioxidant and antisickling activities of <em>Theobroma cocoa </em>extracts combination.<strong> </strong>Cocoa beans Extracts combinations of Santchou/Obala (CSOH), Bertoua/Mbalmayo (CMBH) were prepared using water/ethanol mixture. The antioxidant capacity of extracts was determined by measuring FRAP, DPPH&deg; and ABTS&deg;. The protective activity of extracts was estimated by evaluating some oxidative stress parameters. Osmotic fragility resistance and antisickl
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8

Floriane, Tammo, Cabral Biapa Nya Prosper, Juenkou Tekumu Jesse, et al. "In vitro Antisickling Properties, Free Radicals Quenching Potential, Protective Properties Against Oxidative Mediated ion Toxicity of Combinations of Theobroma cocoa Beans (sterculaceae)." Algerian Journal of Natural Products 7, no. 2 (2019): 718–31. https://doi.org/10.5281/zenodo.3605120.

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Sickle cell anaemia induces an abnormal haemoglobin synthesis and reactive oxygen species. The present work aims to determine the antioxidant and antisickling activities of <em>Theobroma cocoa </em>extracts combination.<strong> </strong>Cocoa beans Extracts combinations of Santchou/Obala (CSOH), Bertoua/Mbalmayo (CMBH) were prepared using water/ethanol mixture. The antioxidant capacity of extracts was determined by measuring FRAP, DPPH&deg; and ABTS&deg;. The protective activity of extracts was estimated by evaluating some oxidative stress parameters. Osmotic fragility resistance and antisickl
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9

Fall, Ahmedou B. K., Michèle Toppet, Alina Ferster, Pierre Fondu, Renée Vanhaelen-Fastré, and Maurice Vanhaelen. "In vitro antisickling activity of cromolyn sodium." British Journal of Haematology 103, no. 4 (1998): 957–59. http://dx.doi.org/10.1046/j.1365-2141.1998.01106.x.

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10

Akojie, F., and L. Fung. "Antisickling Activity of Hydroxybenzoic Acids inCajanus cajan." Planta Medica 58, no. 04 (1992): 317–20. http://dx.doi.org/10.1055/s-2006-961475.

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Dissertations / Theses on the topic "Antisickling activity"

1

Rolan, Paul Edward. "The exploratory clinical development of tucaresol, an antisickling agent, using a novel surrogate marker /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09M.D/09m.dr744.pdf.

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Thesis (M.D.)--University of Adelaide, Dept of Clinical and Experimental Pharmacology, 1995.<br>Copies of author's previously published articles inserted. Describes the exploratory clinical development of tucaresol, consisting of three studies performed on humans and subsequent in vitro and animal studies investigating the possible effects on the immune system. Demostrates that rational drug design may be an efficient way of selecting potential therapeutic candidates.
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2

Rolan, Paul Edward. "The exploratory clinical development of tucaresol, an antisickling agent, using a novel surrogate marker." Thesis, 1995. http://hdl.handle.net/2440/38411.

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Copies of author's previously published articles inserted<br>Describes the exploratory clinical development of tucaresol, consisting of three studies performed on humans and subsequent in vitro and animal studies investigating the possible effects on the immune system. Demonstrates that rational drug design may be an efficient way of selecting potential therapeutic candidates.<br>xxi, 265 leaves<br>Thesis (M.D.) -- University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1995
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