Journal articles on the topic 'Antithrombotic strategies, acute coronary syndrome, ST elevation acute myocardial infarction (STEMI), percutaneous coronary intervention'

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1

Seker, Onur Osman, Idris Bugra Cerik, Metin Coksevim, Mustafa Yenercag, and Korhan Soylu. "Effectiveness of Different P2Y12 Inhibitors on Coronary Flow in Patients with ST-Elevation Myocardial Infarction." Journal Of Cardiovascular Emergencies 6, no. 4 (2020): 91–97. http://dx.doi.org/10.2478/jce-2020-0018.

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Abstract Background: ST-segment elevation myocardial infarction (STEMI) is a clinical syndrome with high mortality. The main purpose of STEMI treatment is to achieve optimal revascularization for tissue perfusion. Besides the innovations in revascularization strategies, developments in antithrombotic therapy resulted in a significant reduction in STEMI-related mortality. Reperfusion can be demonstrated by resolution of ST-segment elevation (STR), TIMI frame count (TFC), and myocardial blush grade (MBG). Aim of the study: In our study, we investigated the effects of P2Y12 inhibitors clopidogrel
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2

Seker, Onur Osman, Idris Bugra Cerik, Metin Coksevim, Mustafa Yenercag, and Korhan Soylu. "Effectiveness of Different P2Y12 Inhibitors on Coronary Flow in Patients with ST-Elevation Myocardial Infarction." Journal Of Cardiovascular Emergencies 6, no. 4 (2020): 91–97. http://dx.doi.org/10.2478/jce-2020-0018.

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AbstractBackground: ST-segment elevation myocardial infarction (STEMI) is a clinical syndrome with high mortality. The main purpose of STEMI treatment is to achieve optimal revascularization for tissue perfusion. Besides the innovations in revascularization strategies, developments in antithrombotic therapy resulted in a significant reduction in STEMI-related mortality. Reperfusion can be demonstrated by resolution of ST-segment elevation (STR), TIMI frame count (TFC), and myocardial blush grade (MBG). Aim of the study: In our study, we investigated the effects of P2Y12 inhibitors clopidogrel,
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3

Kireyev, Dmitriy, Huay Cheem Tan, and Kian Keong Poh. "Management of Acute ST-Elevation Myocardial Infarction: Reperfusion Options." Annals of the Academy of Medicine, Singapore 39, no. 12 (2010): 927–33. http://dx.doi.org/10.47102/annals-acadmedsg.v39n12p927.

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Primary percutaneous coronary intervention and thrombolysis remain therapies of choice for patients presenting with ST-segment elevation myocardial infarction (STEMI). Clinical outcome in the management of acute STEMI is dependent on myocardial reperfusion time and reperfusion strategies. Optimisation of these strategies should take into consideration logistical limitations of the local medical systems and the various patient profiles. We review the reperfusion strategies and its history in Singapore, comparing its clinical application with that in some developed Western countries. Key words:
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Vlachojannis, Georgios J., Bimmer E. Claessen, and George D. Dangas. "Early Stent Thrombosis after Percutaneous Coronary Intervention for Acute Myocardial Infarction." Interventional Cardiology Review 7, no. 1 (2012): 33. http://dx.doi.org/10.15420/icr.2012.7.1.33.

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Stent thrombosis (ST) is the most feared complication of coronary stent treatment because of its morbidity and mortality. Ongoing research is focusing on the frequency and the timing in various patient subsets as well as the factors associated with the occurrence of ST. The mechanism of ST is multifactorial, hence various procedure-, lesion- and patient-related factors have been associated with its occurrence. Beside these factors the role of adjunctive antithrombotic therapy remains unchallenged. Emerging data suggest that primary percutaneous coronary intervention for ST-elevation myocardial
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Kandan, Sri Raveen, and Thomas W. Johnson. "Contemporary Antiplatelet Strategies in the Treatment of STEMI using Primary Percutaneous Coronary Intervention." Interventional Cardiology Review 10, no. 1 (2015): 26. http://dx.doi.org/10.15420/icr.2015.10.1.26.

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Reperfusion therapy for patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) involves primary percutaneous coronary intervention (PPCI) and concomitant oral antiplatelet and intravenous antithrombotic pharmacotherapy. There is a conflict between the desire to reduce the time between first medical contact and coronary re-canalisation and achieving effective platelet inhibition with oral antiplatelet agents. This review outlines the currently available antiplatelet treatments, and their place within the therapeutic timeline of a patient presenting with STEMI. Addi
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Gilyarov, M. Yu, E. V. Konstantinova, M. R. Atabegashvili, et al. "Comorbidities and Percutaneous Coronary Intervention in Elderly Patients with Acute Coronary Syndrome." Rational Pharmacotherapy in Cardiology 17, no. 2 (2021): 221–27. http://dx.doi.org/10.20996/1819-6446-2021-04-10.

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Aim. To assess comorbidities in elderly patients with acute coronary syndrome (ACS) and to analyze patient subgroups with different treatment strategies in the Regional Vascular Center (RVC).Material and methods. The prospective study included 205 patients with confirmed ACS 75 years and older, the mean age was 81±4.9 years, and 68% were women. ST segment elevation myocardial infarction (STEMI) was diagnosed in 46 (22.4 %) patients, non-ST segment elevation myocardial infarction (NSTEMI) was diagnosed in 159 (77,6 %) patients. The Charlson Comorbidity Index (CCI) was calculated in every patien
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7

Thani, Khalid Bin, Fajer Al-Moosa, Eman Murad, Aisha Al-Moosa, Mohamed E. Alalawi, and Hind Al-Sindi. "Stent Thrombosis after Rescue Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction." Open Cardiovascular Medicine Journal 9, no. 1 (2015): 127–32. http://dx.doi.org/10.2174/1874192401509010127.

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Main Problem:To determine the incidence of coronary stent thrombosis (ST) in patients with acute ST segment elevation myocardial infarction (STEMI) after rescue percutaneous coronary intervention (PCI). Methods:An observational study looking at the incidence of ST in a middle-eastern population. A total of 510 consecutive patients presented with ST-segment elevation myocardial infarction (STEMI) were enrolled and underwent thrombolytic therapy with a total follow-up period of 2 years. Study outcomes were ST, death, re-infarction or acute coronary syndrome requiring coronary angiography and PCI
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8

Zeymer, Uwe, Peter Ludman, Nicolas Danchin, et al. "The ESC ACCA EAPCI EORP acute coronary syndrome ST-elevation myocardial infarction registry." European Heart Journal - Quality of Care and Clinical Outcomes 6, no. 2 (2019): 100–104. http://dx.doi.org/10.1093/ehjqcco/qcz042.

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Abstract Aims The Acute Cardiac Care Association (ACCA)–European Association of Percutaneous Coronary Intervention (EAPCI) Registry on ST-elevation myocardial infarction (STEMI) of the EurObservational programme (EORP) of the European Society of Cardiology (ESC) registry aimed to determine the current state of the use of reperfusion therapy in ESC member and ESC affiliated countries and the adherence to ESC STEMI guidelines in patients with STEMI. Methods and results Between 1 January 2015 and 31 March 2018, a total of 11 462 patients admitted with an initial diagnosis of STEMI according to th
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9

Fallahzadeh, Aida, Ali Sheikhy, Afsaneh Aein, et al. "Outcome of Percutaneous Coronary Intervention in Old Patients Presenting with Acute Coronary Syndrome." Archives of Iranian Medicine 25, no. 8 (2022): 523–32. http://dx.doi.org/10.34172/aim.2022.84.

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Background: Octogenarians (age≥80 years) with coronary artery disease constitute a high-risk group and the elderly undergoing percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared to young patients. In this study, we aimed to describe the outcomes of the elderly with acute coronary syndrome (ACS) who underwent PCI and also to identify the predictors of short-term major adverse cerebrocardiovascular events (MACCE) in octogenarians. Methods: In this registry-based cohort study, we reviewed the data of patients (aged≥65 years) who underwent PCI. Univariate Cox-r
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Kedev, Sasko. "The Role of the Transradial Approach for Complex Coronary Interventions in Patients with Acute Coronary Syndrome." Interventional Cardiology Review 8, no. 2 (2013): 81. http://dx.doi.org/10.15420/icr.2013.8.2.81.

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Despite advances in antithrombotic and antiplatelet therapy, bleeding complications remain an important cause of morbidity and mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). A significant proportion of such bleedings are related to the access site, and adoption of transradial access (TRA) may reduce these complications. In patients with ST-segment elevation myocardial infarction (STEMI), TRA reduced cardiac mortality in comparison with the femoral approach (TFA). High-risk patients such as women, obese patients and elderly subjects
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11

Eliaz, Ran, Bethlehem Mengesha, Tal Ovdat, et al. "Ticagrelor versus Prasugrel in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Analysis from the Acute Coronary Syndrome Israeli Survey." Cardiology 147, no. 2 (2021): 113–20. http://dx.doi.org/10.1159/000521042.

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<b><i>Introduction:</i></b> We aimed to compare the outcomes of acute coronary syndrome (ACS) patients undergoing in-hospital percutaneous coronary intervention treated with prasugrel versus ticagrelor. <b><i>Methods:</i></b> Among 7,233 patients enrolled to the Acute Coronary Syndrome Israeli Survey (ACSIS) between 2010 and 2018, we identified 1,126 eligible patients treated with prasugrel and 817 with ticagrelor. Comparison between the groups was performed separately in ST-elevation myocardial infarction (STEMI) patients, propensity score match
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Tsang, Michael, and Sanjit Jolly. "Interventional Strategies in Thrombus Management for ST Elevation Myocardial Infarction." Interventional Cardiology Review 10, no. 1 (2015): 35. http://dx.doi.org/10.15420/icr.2015.10.1.35.

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The major limitation of modern primary percutaneous coronary intervention (PPCI) is distal embolisation of thrombus and microvascular obstruction. Microvascular flow, as measured by myocardial blush grade (MPG), predicts mortality after PPCI. Despite initial enthusiasm, current evidence does not support routine use of Intracoronary over intravenous glycoprotein 2b3a inhibitors during PPCI for ST elevation myocardial infarction (STEMI) to improve clinical outcomes. Manual thrombectomy (MT) improves MPG and reduces distal embolisation in meta-analyses of small trials. A single-centre trial (N=10
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13

Jiang, Dongmei, and Guosheng Fu. "A case of de Winter syndrome presenting with chest tightness." Journal of International Medical Research 49, no. 7 (2021): 030006052110121. http://dx.doi.org/10.1177/03000605211012198.

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de Winter syndrome, also termed anterior ST-segment elevation myocardial infarction (STEMI) equivalent, is estimated to be present in approximately 2% of patients with acute myocardial infarction, but is often under-recognized by clinicians. Therefore, de Winter syndrome is associated with increased morbidity and mortality. We report a 51-year-old man with typical chest tightness and a characteristic electrocardiographic pattern without classic ST-segment elevation, but with acute nearly total occlusion of the left anterior descending coronary artery. Although the patient presented as a non-ST
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14

Djuric, Predrag, Slobodan Obradovic, Zoran Stajic, et al. "Very late stent thrombosis of bare-metal coronary stent nine years after primary percutaneous coronary intervention." Vojnosanitetski pregled 73, no. 8 (2016): 774–78. http://dx.doi.org/10.2298/vsp141222053d.

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Introduction. Stent thrombosis (ST) in clinical practice can be classified according to time of onset as early (0?30 days after stent implantation), which is further divided into acute (< 24 hours) and subacute (1?30 days), late (> 30 days) and very late (> 12 months). Myocardial reinfaction due to very late ST in a patient receiving antithrombotic therapy is very rare, and potentially fatal. The procedure alone and related mechanical factors seem to be associated with acute/subacute ST. On the other hand, in-stent neoathero-sclerosis, inflammation, premature cessation of antiplatelet
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15

Vereshchagin, I. E., V. I. Ganyukov, and I. N. Mamchur. "CARDIOPROTECTION IN PATIENTS WITH ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION." Complex Issues of Cardiovascular Diseases 8, no. 3 (2019): 52–59. http://dx.doi.org/10.17802/2306-1278-2019-8-3-52-59.

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Aim To evaluate cardioprotective effects of combined intracoronary phosphocreatine and succinic acid administration after primary percutaneous coronary intervention (PCI) in patients with ST elevation acute coronary syndrome who were present within 12 hours of symptom onset.Methods Seven patients with STEMI presenting within 12 hours of onset of symptoms and thrombotic occlusion of the left anterior descending artery were included in the study. Evaluation of efficiency and safety was performed with the recording of major adverse cardiac events, evaluation of the procedure success, and the rate
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Enache, Iulian, Răzvan Alexandru Radu, Elena Oana Terecoasă, Bogdan Dorobăţ, and Cristina Tiu. "Stress cardiomyopathy misinterpreted as ST-segment elevation myocardial infarction in a patient with aneurysmal subarachnoid hemorrhage: a case report." Romanian Journal of Internal Medicine 58, no. 3 (2020): 173–77. http://dx.doi.org/10.2478/rjim-2020-0010.

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AbstractCardiac abnormalities are frequently reported in acute subarachnoid hemorrhage (SAH) patients. However, frank ST-elevation and myocardial dysfunction mimicking acute coronary syndrome is a rare occurrence. Systemic and local catecholamine release mediate myocardial injury and may explain raised troponin levels, concordant regional wall motion abnormalities and systolic dysfunction. These findings can pose a significant problem in the acute setting where “time-is-muscle” paradigm can rush clinicians towards a “rule-in” diagnosis of acute myocardial infarction.We present the case of a 60
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Aghlmandi, Soheila, Nadine Schärer, Dik Heg, et al. "Thrombus aspiration in acute coronary syndromes: prevalence, procedural success, change in serial troponin T levels and clinical outcomes in a contemporary Swiss cohort." European Heart Journal: Acute Cardiovascular Care 7, no. 6 (2017): 522–31. http://dx.doi.org/10.1177/2048872617706480.

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Background: Randomised controlled trials have provided conflicting results regarding procedural and clinical outcomes of thrombus aspiration combined with percutaneous coronary intervention, when compared with primary percutaneous coronary intervention alone in patients with acute coronary syndromes. Methods: Acute coronary syndrome patients referred for coronary angiography to four Swiss university hospitals between 2009 and 2012 were enrolled in the SPUM–ACS cohort. At the discretion of the interventional cardiologist, patients underwent thrombus aspiration with percutaneous coronary interve
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18

Crouch, Michael A., Jean M. Nappi, and Kai I. Cheang. "Glycoprotein IIb/IIIa Receptor Inhibitors in Percutaneous Coronary Intervention and Acute Coronary Syndrome." Annals of Pharmacotherapy 37, no. 6 (2003): 860–75. http://dx.doi.org/10.1345/aph.1c338.

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OBJECTIVE: To review the contemporary role of the glycoprotein (GYP) IIb/IIIa receptor inhibitors abciximab, eptifibatide, and tirofiban in patients undergoing percutaneous coronary intervention (PCI) and those with an acute coronary syndrome (ACS), and to provide an algorithm based on currently available evidence for specific agents. DATA SOURCES: Primary articles were identified by a MEDLINE search (1966–January 2003); references cited in these articles provided additional resources. STUDY SELECTION AND DATA EXTRACTION: All of the articles identified from data sources were considered for rel
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Oktaviono, Yudi Her, and Feranti Meuthia. "Thrombocytopenia in a Patient Undergoing Primary Percutaneous Coronary Intervention." Folia Medica Indonesiana 55, no. 1 (2021): 68. http://dx.doi.org/10.20473/fmi.v55i1.24434.

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Thrombocytopenia is a common abnormality in patients presenting with acute coronary syndrome. Baseline thrombocytopenia in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention is associated with early adverse events, related to both ischemia and bleeding. Treatment for acute coronary syndrome usually involves antiplatelet, anticoagulant, antithrombotic therapy, and the performance of percutaneous coronary intervention. The safety of antiplatelet therapy and percutaneous coronary intervention patients who have acute coronary syndrome and thrombo
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Ozaki, Yukio, Hironori Hara, Yoshinobu Onuma, et al. "CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) update 2022." Cardiovascular Intervention and Therapeutics 37, no. 1 (2022): 1–34. http://dx.doi.org/10.1007/s12928-021-00829-9.

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AbstractPrimary Percutaneous Coronary Intervention (PCI) has significantly contributed to reducing the mortality of patients with ST-segment elevation myocardial infarction (STEMI) even in cardiogenic shock and is now the standard of care in most of Japanese institutions. The Task Force on Primary PCI of the Japanese Association of Cardiovascular Interventional and Therapeutics (CVIT) society proposed an expert consensus document for the management of acute myocardial infarction (AMI) focusing on procedural aspects of primary PCI in 2018. Updated guidelines for the management of AMI were publi
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Oktaviono, Yudi Her, and Feranti Meuthia. "Case report: Thrombocytopenia in a Patient Undergoing Primary Percutaneous Coronary Intervention." Folia Medica Indonesiana 55, no. 1 (2019): 68. http://dx.doi.org/10.20473/fmi.v55i1.12562.

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Thrombocytopenia is a common abnormality in patients presenting with acute coronary syndrome. Baseline thrombocytopenia in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention is associated with early adverse events, related to both ischemia and bleeding. Treatment for acute coronary syndrome usually involves antiplatelet, anticoagulant, antithrombotic therapy, and the performance of percutaneous coronary intervention. The safety of antiplatelet therapy and percutaneous coronary intervention patients who have acute coronary syndrome and thrombo
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Cодномова, Лариса, Larisa Sodnomova, Наталья Булутова, and Natalya Bulutova. "EFFICIENCY OF INVASIVE REVASCULARIZATION FOR ACUTE CORONARY SYNDROME WITH ST ELEVATION." Acta biomedica scientifica 2, no. 5 (2018): 55–59. http://dx.doi.org/10.12737/article_5a3a0dba5f2a88.40775068.

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The primary and main method of treating ACS with ST elevation is timely restoration of coronary vessel patency.
 Material and methods. 273 medical records of patients admitted with provisional diagnosis of ACS with ST elevation
 were studied. Statistical data were processed in Microsoft Excel and Statistica 10 (StatSoft Inc., USA).
 Results. One third of patients with ACS with ST elevation were admitted at «the golden hour» since symptoms onset.
 234 (86 %) patients underwent coronary angiography. Primary percutaneous intervention (PCI), coronary stenting were
 perform
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23

Stepinska, Janina, Izabela Wojtkowska, Lieven Annemans, et al. "Long-Term Outcome of Acute Coronary Syndromes in Patients on Chronic Oral Anticoagulants: Data from the EPICOR Study." Current Vascular Pharmacology 18, no. 1 (2019): 92–99. http://dx.doi.org/10.2174/1570161117666181227122355.

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Objective: To analyze characteristics, management and outcomes of patients with acute coronary syndromes (ACS) receiving chronic oral anticoagulant (OAC) therapy enrolled in the EPICOR (long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients) prospective, international, observational study of antithrombotic management patterns in ACS survivors (NCT01171404). Methods: This post-hoc analysis evaluated the association between OAC use at baseline (OACb) and time from hospital admission to percutaneous coronary intervention (PCI) (tHA-PCI), pre-PCI thrombolysis
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Zameer, Imran, Muhammad Kashif, Akasha Perveez, et al. "In-Hospital Outcomes of Patients Presenting with Acute Anterior STEMI with Right Bundle Branch Block." Pakistan Armed Forces Medical Journal 72, SUPPL-3 (2022): S518–23. http://dx.doi.org/10.51253/pafmj.v72isuppl-3.9610.

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Objective: To assess the in-hospital outcomes in Anterior wall ST Elevation Myocardial Infarction patients presenting with Right Bundle Branch Block with different reperfusion strategies.
 Study Design: Analytical Cross-Sectional Study.
 Place and Duration of Study: Department of Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi Pakistan, from Sep 2020 to Feb 2021.
 Methodology: Patients with myocardial infarction who presented to the emergency department of the hospital were included in the study. Further evaluation was performed on individuals with ST elevation in ant
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Shaikh, Sanaullah, Vashu Mal, Jagdesh Kumar, Suhail Ahmed, Faraz Farooq Memon, and Bilawal Adrani. "The Frequency of Early Subacute Stent Thrombosis after Primary Percutaneous Coronary Intervention in Patients with St-Segment Elevation Myocardial Infarction." Pakistan Journal of Medical and Health Sciences 16, no. 1 (2022): 530–34. http://dx.doi.org/10.53350/pjmhs22161530.

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Introduction: Acute coronary syndrome(ACS) is associated with activation ofplateletsand thecoagulationsystem which could influence the incidence of early stentthrombosis(EST).Stent thrombosis is a relatively uncommon phenomenon, yet it is a serious complication which often presents as an ST-segment elevation myocardial infarction (STEMI) and/or sudden cardiac death1,2.Stent thrombosis (ST) is an uncommon but life-threatening complication after percutaneous coronary intervention (PCI), frequently manifesting as acute coronary syndrome (ACS) or even cardiac death.Platelet activation and the heig
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Fernández-Bergés, Daniel, Irene R. Degano, Reyes Gonzalez Fernandez, et al. "Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction." Open Heart 7, no. 2 (2020): e001169. http://dx.doi.org/10.1136/openhrt-2019-001169.

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ObjectivePrimary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI than younger patients despite their higher in-hospital morbimortality. The objective of this analysis was to determine the effectiveness of P-PCI in patients with STEMI ≥75 years.MethodsWe included 979 patients with STEMI ≥75 years, from the ATención HOspitalaria del Síndrome coronario study, a registry of 8142 consecutive patients with acute coronary syndrome admitted at 31 Spani
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Hadadi, László, Paul Calburean, Paul Grebenisan, et al. "Mortality predictors after percutaneous coronary intervention – a prospective single-center registry study." Romanian Journal of Cardiology 30, no. 3 (2020): 413–22. http://dx.doi.org/10.47803/rjc.2020.30.3.413.

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Objectives – To evaluate the predictors of three-year cardiovascular mortality after percutaneous coronary intervention (PCI) in a Romanian tertiary cardiovascular center. Methods – Consecutive patients treated by PCI in the Emergency Institute for Cardiovascular Diseases and Transplantation of Targu Mures were included prospectively in a local PCI Registry. Demographic, clinical, and procedural parameters of the patients enrolled in the year 2016 were statistically analyzed as possible predictors of three-year cardiovascular mortality post-PCI. Results – 1079 patients were included: 254 (23.5
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Baumann, Angus A. W., Aashka Mishra, Matthew I. Worthley, Adam J. Nelson, and Peter J. Psaltis. "Management of multivessel coronary artery disease in patients with non-ST-elevation myocardial infarction: a complex path to precision medicine." Therapeutic Advances in Chronic Disease 11 (January 2020): 204062232093852. http://dx.doi.org/10.1177/2040622320938527.

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Recent analyses suggest the incidence of acute coronary syndrome is declining in high- and middle-income countries. Despite this, overall rates of non-ST-elevation myocardial infarction (NSTEMI) continue to rise. Furthermore, NSTEMI is a greater contributor to mortality after hospital discharge than ST-elevation myocardial infarction (STEMI). Patients with NSTEMI are often older, comorbid and have a high likelihood of multivessel coronary artery disease (MVD), which is associated with worse clinical outcomes. Currently, optimal treatment strategies for MVD in NSTEMI are less well established t
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Montone, Rocco A., Giampaolo Niccoli, Filippo Crea, and Ik-Kyung Jang. "Management of non-culprit coronary plaques in patients with acute coronary syndrome." European Heart Journal 41, no. 37 (2020): 3579–86. http://dx.doi.org/10.1093/eurheartj/ehaa481.

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Abstract Approximately 50% of patients with ST-segment elevation myocardial infarction (STEMI) have multivessel coronary artery disease, a condition associated with an increased incidence of recurrent ischaemic events and higher mortality. Based on recent evidences, a strategy of staged percutaneous coronary intervention (PCI) of obstructive non-culprit lesions should be considered the gold standard for the management of these patients. However, several issues remain still unresolved. Indeed, what is the optimal timing of staged PCI is not completely defined. Moreover, assessment of intermedia
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Sen, Gautam, Alice Veitch, and Sergio Nabais. "Anterior STEMI complicating acute aortic syndrome: mechanistic insight and bridge to surgery with intravascular ultrasound-guided primary PCI." BMJ Case Reports 15, no. 3 (2022): e248055. http://dx.doi.org/10.1136/bcr-2021-248055.

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Stanford type A acute aortic syndromes (AAS) can be complicated with acute coronary closure and ST segment elevation myocardial infarction (STEMI) leading to significant additional morbidity and mortality. The recommended treatment for type A AAS is emergency cardiac surgery. We present the case of a patient with intramural haematoma involving the ascending and descending aorta complicated with anterior wall STEMI after CT imaging. Coronary angiography and intravascular ultrasonography (IVUS) revealed the dissection spiralling into the media of the left main stem (LMS) and left anterior descen
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Lazar, Roxana-Daiana, Abigaela Rus, Cosmin Tolescu, Renata Gerculy, Diana Opincariu, and Imre Benedek. "Spontaneous Coronary Artery Dissection and Anomalous Coronary Origin – Underlying Cause of Acute Coronary Syndrome in a Young Woman: A Case Report." Journal Of Cardiovascular Emergencies 7, no. 1 (2021): 22–26. http://dx.doi.org/10.2478/jce-2020-0017.

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Abstract Introduction: Spontaneous coronary artery dissection (SCAD) represents a very rare and poorly understood condition that is gaining recognition as an important cause of myocardial infarction, especially among young women. The pathogenesis of SCAD is not well established yet, but several theories have been proposed. Case presentation: We report the case of a 25-year-old woman without any history of cardiovascular disease who presented with acute anterior ST-elevation myocardial infarction (STEMI) due to the luminal obstruction generated by an intramural hematoma from a SCAD of the left
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Opolonskaya, P. E., N. I. Maximov, and M. Yu Smetanin. "Effect of obstructive sleep apnea syndrome on left ventricular remodeling in acute ST-elevation myocardial infarction after percutaneous coronary intervention." Siberian Journal of Clinical and Experimental Medicine 35, no. 3 (2020): 100–106. http://dx.doi.org/10.29001/2073-8552-2020-35-3-100-106.

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Introduction. Patients with obstructive sleep apnea syndrome (OSA) may have features of acute ST-segment elevation myocardial infarction (STEMI). We assumed that the previous OSA due to acute and chronic hypoxia has a “protective” effect on myocardial damage in STEMI. To assess the damage to the myocardium, we selected the index of local contractility disorders (ILCD), and used the oxygen desaturation index (ODI) to assess OSA’s severity.Aim. To study the relationship between myocardial damage and the severity of OSA in STEMI after percutaneous coronary intervention (PCI).Material and Methods.
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Wiggins, Barbara S., and Sarah Spinler. "Antiplatelet and Antithrombin Therapy for Early Management of Acute Coronary Syndromes." Journal of Pharmacy Practice 17, no. 5 (2004): 347–69. http://dx.doi.org/10.1177/0897190004271778.

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Acute coronary syndromes (ACS) are defined as either unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Their management is continuously evolving in terms of pharmacologic therapy. The usual cause of ACS is the disruption of an atherosclerotic plaque leading to formation of a thrombus within a coronary artery. Initial antiplatelet and antithrombin therapy for patients with ST-segment elevation (STE) ACS includes aspirin and unfractionated heparin (UFH). Patients presenting to the hospital early may undergo percu
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Galappatthy, Priyadarshani, Vipula R. Bataduwaarachchi, Priyanga Ranasinghe, et al. "Management, characteristics and outcomes of patients with acute coronary syndrome in Sri Lanka." Heart 104, no. 17 (2018): 1424–31. http://dx.doi.org/10.1136/heartjnl-2017-312404.

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BackgroundIschaemic heart disease is the leading cause of in-hospital mortality in Sri Lanka. Acute Coronary Syndrome Sri Lanka Audit Project (ACSSLAP) is the first national clinical-audit project that evaluated patient characteristics, clinical outcomes and care provided by state-sector hospitals.MethodsACSSLAP prospectively evaluated acute care, in-hospital care and discharge plans provided by all state-sector hospitals managing patients with ACS. Data were collected from 30 consecutive patients from each hospital during 2–4 weeks window. Local and international recommendations were used as
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Sultana, Syeda Aleya, Syed Asif Iqbal, Md Abdul Malek, et al. "A Comparative Study on Short-term Clinical Outcome in Acute Coronary Syndrome." Journal of Armed Forces Medical College, Bangladesh 13, no. 1 (2017): 22–27. http://dx.doi.org/10.3329/jafmc.v13i1.41011.

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Introduction: Coronary artery diseases are currently the major cause of death in developing countries. Acute coronary syndrome (ACS) is defined as any group of clinical symptoms compatible with acute myocardial ischemia and covers the spectrum of clinical conditions ranging from unstable angina (UA) to non-ST elevation myocardial infarction (NSTEMI) to STelevation myocardial infarction (STEMI). Accurate diagnosis and management of ACS has life-saving implications of its outcome.
 Objective: To compare the outcomes of STEMI and NSTEMI in a percutaneous coronary intervention (PCI) capable c
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Liu, Yuan-Hui, Lei Jiang, Chong-Yang Duan, et al. "Canada Acute Coronary Syndrome Score: A Preprocedural Risk Score for Contrast-Induced Nephropathy After Primary Percutaneous Coronary Intervention." Angiology 68, no. 9 (2017): 782–89. http://dx.doi.org/10.1177/0003319717690674.

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In patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, contrast-induced nephropathy (CIN) is a serious complication associated with poor outcomes. We assessed the predictive value of the Canada Acute Coronary Syndrome (C-ACS) score for CIN in these patients. A total of 394 consecutive patients with STEMI were enrolled and divided into 3 groups according to their C-ACS scores—group 1, score 0; group 2, score 1; and group 3, score ≥2. The clinical outcomes were CIN and major adverse clinical events (MACEs) during hospital and fo
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M, Anupama, Sharath JV, and Shetty GG. "A study to compare fibrinolytic therapy versus primary percutaneous coronary intervention in ST-segment elevation myocardial infarction in a tertiary care hospital." National Journal of Physiology, Pharmacy and Pharmacology 13, no. 5 (2022): 1. http://dx.doi.org/10.5455/njppp.2023.13.09472202202102022.

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Background: ST-segment elevation myocardial infarction (STEMI) is the most dramatic manifestation of coronary artery disease, acute STEMI is a clinical syndrome defined by characteristic symptoms of myocardial ischemia in association with persistent electrocardiographic ST elevation and subsequent release of biomarkers of myocardial necrosis. Reperfusion with thrombolysis or PCI (percutaneous coronary intervention) is the current standard of care for STEMI. Aims and Objectives: The aim of the study was to compare the effectiveness of fibrinolytic therapy and primary PCI which are the available
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Aurigemma, Cristina, Giancarla Scalone, Fabrizio Tomai, et al. "Persistent enhanced platelet activation in patients with acute myocardial infarction and coronary microvascular obstruction: clinical implications." Thrombosis and Haemostasis 111, no. 01 (2014): 122–30. http://dx.doi.org/10.1160/th13-02-0166.

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SummaryAbout 30% of patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing recanalisation of the infarct-related coronary artery do not achieve valid myocardial reperfusion (no-reflow phenomenon or coronary microvascular obstruction [MVO]). The mechanisms of MVO are incompletely understood. In this study we investigated the role platelet activation in the pathogenesis of coronary MVO in STEMI patients. We enrolled 48 STEMI patients (age 56.2 ± 11 years; 31 men), treated by primary percutaneous coronary intervention (PCI) followed by double anti-platelet treatment, an
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Christ, Günter, Jolanta M. Siller-Matula, Marcel Francesconi, Cornelia Dechant, Katharina Grohs, and Andrea Podczeck-Schweighofer. "Individualising dual antiplatelet therapy after percutaneous coronary intervention: the IDEAL-PCI registry." BMJ Open 4, no. 10 (2014): e005781. http://dx.doi.org/10.1136/bmjopen-2014-005781.

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ObjectiveTo evaluate the clinical utility of individualising dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in an all-comers population, including ST-elevation myocardial infarction (STEMI) patients.SettingTertiary care single centre registry.Participants1008 consecutive PCI patients with stent implantation, without exclusion criteria.InterventionPeri-interventional individualisation of DAPT, guided by multiple electrode aggregometry (MEA), to overcome high on-treatment platelet reactivity (HPR) to ADP-induced (≥50 U) and arachidonic acid (AA)-induced aggregati
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Bocharov, Aleksandr V., and Leonid V. Popov. "Comparison of strategies for myocardial revascularization in patients with coronary heart disease and multivessel coronary artery disease." Journal of Clinical Practice 10, no. 4 (2020): 30–35. http://dx.doi.org/10.17816/clinpract12631.

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Justification. To this day, the problem of choosing the method of complete revascularization in the category of patients with acute coronary syndrome without the ST segment elevation and multi-vascular lesions of the coronary bed does not lose its relevance. The goal of this study was to compare the results of surgical manipulations in patients who underwent percutaneous coronary intervention using 3rd-generation drug-coated stents and coronary artery bypass grafting, according to the two-year follow-up data.
 Methods. The results of surgical and endovascular revascularization strategies
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Chen, Hongwu, Xiaofan Yu, Xiangyong Kong, Longwei Li, Jiawei Wu, and Likun Ma. "Efficacy and safety of bivalirudin application during primary percutaneous coronary intervention in older patients with acute ST-segment elevation myocardial infarction." Journal of International Medical Research 48, no. 9 (2020): 030006052094794. http://dx.doi.org/10.1177/0300060520947942.

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Objective ST-segment elevation myocardial infarction (STEMI) is the most serious type of acute coronary syndrome. This study aimed to investigate the efficacy and safety of bivalirudin application during primary percutaneous coronary intervention (PPCI) in older patients with acute STEMI. Methods A total of 672 older patients with STEMI (>75 years) who underwent PPCI were studied. The primary endpoints were 30-day net adverse clinical events (NACEs) post-emergency percutaneous coronary intervention, including major adverse cardiac and cerebrovascular events (MACCEs) and Bleeding Academic Re
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Ryabov, V. V., S. K. Demianov, A. G. Syrkina, et al. "Quality of care for patients with myocardial infarction with ST segment elevation. real clinical practice of the invasive center." Clinical Medicine (Russian Journal) 96, no. 6 (2018): 506–11. http://dx.doi.org/10.18821/0023-2149-2018-96-6-506-511.

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According to the Russian registry RECORD, the hospital mortality at STEMI in domestic hospitals remains high, which is due to the low frequency of reperfusion measures. There are problems in treatment patients of senile age. Comparative studies of the quality of care for patients with acute coronary syndrome were not conducted in Russia. 489 patients with STEMI, arrived in the first 24 hours from the onset of MI were analyzed. Quality of care for patients with STEMI was evaluated according to the quality criteria of the Association of Emergency Cardiovascular Care of the European Society of Ca
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Indah, Aprila Aqmarina, Praditya Virza Ramadhan, Vireza Pratama, Haikal Haikal, and Irnizarifka Irnizarifka. "Acute Coronary Syndrome in Well Trained Young Adult: A Rare Cases." Cardiovascular and Cardiometabolic Journal (CCJ) 1, no. 2 (2020): 69. http://dx.doi.org/10.20473/ccj.v1i2.2020.69-76.

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Acute Coronary Syndrome (ACS) has been observed in the older population (>40 years old), sedentary lifestyle and unhealthy behaviour. Recently, there is an increase of ACS reported in the younger population even without a sedentary lifestyle.We report a case of awell-trained 25-years old man thatcame with late presentation of ST elevation myocardial infarction (STEMI) occurred 10 minutes after vigorous exercise. His traditional risk factor was a smoker.Electrocardiogram (ECG) showed a pathological Q wave in V1-V3 and T wave inversion in V1-V6 with elevated cardiac biomarker. Primary percuta
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George, Jisa, and Malathy A.R. "Efficacy of Quantitative Troponin I in Predicting Cardiovascular Outcome in ST Segment Elevation Myocardial Infarction / Non-ST Segment Elevation Myocardial Infarction (STEMI / NSTEMI) Patients - A Retrospective Study from a Centre in South India." Journal of Evidence Based Medicine and Healthcare 8, no. 14 (2021): 877–81. http://dx.doi.org/10.18410/jebmh/2021/171.

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BACKGROUND Cardiac biomarkers like troponin play a very important role in the diagnosis of acute myocardial infarction. In a developing country like India, though the burden of cardiovascular diseases is on the rise, majority of the patients with acute coronary syndrome do not have access to primary percutaneous coronary intervention (PCI) facilities. Few Indian studies have looked into the utility of the quantitative troponin levels in predicting the cardiovascular outcome of non-ST segment elevation myocardial infarction / ST segment elevation myocardial infarction STEMI / NSTEMI patients; t
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Kadloor, Parvaiz, Mohammed Hidayathullah, and Abhishek Golla. "Reduced left ventricular ejection fraction in patients with acute coronary syndrome as a risk factor for mortality." International Journal of Research in Medical Sciences 10, no. 1 (2021): 80. http://dx.doi.org/10.18203/2320-6012.ijrms20215035.

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Background: The study aimed to evaluate left ventricular ejection fraction (LVEF) as the risk factor for mortality in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).Methods: This was an observational, single centre study. The patients who were admitted at tertiary care centre in India during the period February 2014 to June 2015 who were diagnosed with ACS were included in the study. The patients were evaluated by dividing into two groups based on LVEF. The patients were followed up to 1 year.Results: Total 100 patients were included in the study. Ch
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Kohan, Marío R., Virginia Messler, Horacio Buffa, et al. "Reperfusion Times in a Telemedicine-guided Program for the Management of ST-segment Elevation Myocardial Infarction in the Province of La Pampa." Revista Argentina de Cardiologia 90, no. 4 (2022): 268–73. http://dx.doi.org/10.7775/rac.v90.i4.20536.

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Background: Timing of medical care is a relevant factor for ST-segment elevation myocardial infarction (STEMI) mortality. Objectives: The aim of the present study is to evaluate reperfusion times in STEMI patients participating in a telemedicine-based cardiology care program in the province of La Pampa between August 2018 and December 2021. Methods: This program consists of a protocol for the management of patients with acute coronary syndrome (ACS) in the different locations of the province, with 24-hour remote assistance provided by cardiologists, including both diagnostic support and coordi
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Maharjan, Prabindra, Reezu Manandhar, Wei Xu, et al. "Markers of Autolysis in Acute ST Elevation Myocardial Infarction – A Comparative Analysis." Journal of Nepal Medical Association 53, no. 198 (2015): 96–103. http://dx.doi.org/10.31729/jnma.2769.

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Introduction: The availability of reliable noninvasive markers for infarct-related artery patency status are very limited, otherwise could allow early identification of patients with patent IRA, for whom repeat thrombolysis or rescue percutaneous coronary intervention are not necessary.
 Methods: We conducted a single centered retrospective study of STEMI patients undergoing primary PCI to determine how various factors such as demographic characteristics, risk markers of coronary heart disease, clinical and blood parameters present differently in patients with higher coronary flow and pat
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Rakowski, Tomasz, Dariusz Dudek, Arnoud van ’t Hof, et al. "Impact of acute infarct-related artery patency before percutaneous coronary intervention on 30-day outcomes in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention in the EUROMAX trial." European Heart Journal: Acute Cardiovascular Care 7, no. 6 (2017): 514–21. http://dx.doi.org/10.1177/2048872617690888.

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Aims: Early infarct-related artery patency has been associated with improved outcomes in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. However, it is unknown whether this relationship persists in contemporary practice with pre-hospital initiation of treatment, use of novel P2Y12 inhibitors and frequent use of drug-eluting stents. The purpose of the study was to determine the impact of early infarct-related artery patency on outcomes in the contemporary EUROMAX trial. Methods and results: A total of 2218 patients were enrolled.
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Flores-Salinas, Héctor E., Fidel Casillas-Muñoz, Yeminia Valle, Cesar M. Guzmán-Sánchez, and Jorge Ramon Padilla-Gutiérrez. "Good Practices in the Clinical Management of Patients with Acute Coronary Syndrome: Retrospective Analysis in a Third-Level Hospital in Mexico." Cardiology Research and Practice 2020 (July 6, 2020): 1–7. http://dx.doi.org/10.1155/2020/9624283.

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Introduction and Objective. In Mexico, there has been an increase in the risk of cardiovascular disease due to rising life expectancy, westernized lifestyle, lack of prevention, and industrialized exposure. This article describes the pharmacological treatment, surgical interventions, and associated clinical complications in patients diagnosed with acute coronary syndrome (ACS) and their impact on in-hospital mortality frequency in a Cardiology Unit in Instituto Mexicano del Seguro Social. Methods. This is a retrospective study including male and female patients aged ≥18 years who were diagnose
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Berbis, Julie, Marc Laine, Sébastien Armero, et al. "Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction." Thrombosis and Haemostasis 108, no. 07 (2012): 101–6. http://dx.doi.org/10.1160/th12-02-0125.

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SummaryOptimal platelet reactivity (PR) inhibition is critical to prevent thrombotic events in primary percutaneous coronary intervention (PCI). We aimed to determine the relationship between high on-treatment platelet reactivity (HTPR) and ST-elevation myocardial infarction (STEMI) following a 600 mg loading dose (LD) of clopidogrel. We performed a prospective monocentre study enrolling patients on clopidogrel undergoing PCI. The VASP index was used to assess PR inhibition after clopidogrel LD. HTPR was defined according to the consensus as a VASP index ≥50%. The present study included 833 pa
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