Academic literature on the topic 'Antitrypanosomal agents'
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Journal articles on the topic "Antitrypanosomal agents"
Steverding, Dietmar, and Kevin M. Tyler. "Novel antitrypanosomal agents." Expert Opinion on Investigational Drugs 14, no. 8 (July 29, 2005): 939–55. http://dx.doi.org/10.1517/13543784.14.8.939.
Full textIssa, Victor Sarli, and Edimar Alcides Bocchi. "Antitrypanosomal agents: treatment or threat?" Lancet 376, no. 9743 (September 2010): 768. http://dx.doi.org/10.1016/s0140-6736(10)61372-4.
Full textSchmidt, Ines, Sarah Göllner, Antje Fuß, August Stich, Anna Kucharski, Tanja Schirmeister, Elena Katzowitsch, et al. "Bistacrines as potential antitrypanosomal agents." Bioorganic & Medicinal Chemistry 25, no. 16 (August 2017): 4526–31. http://dx.doi.org/10.1016/j.bmc.2017.06.051.
Full textRyczak, Jasmin, Ma'ayan Papini, Annette Lader, Abedelmajeed Nasereddin, Dmitry Kopelyanskiy, Lutz Preu, Charles L. Jaffe, and Conrad Kunick. "2-Arylpaullones are selective antitrypanosomal agents." European Journal of Medicinal Chemistry 64 (June 2013): 396–400. http://dx.doi.org/10.1016/j.ejmech.2013.03.065.
Full textRassi, Anis, Anis Rassi, and José Antonio Marin-Neto. "Antitrypanosomal agents: treatment or threat? – Authors' reply." Lancet 376, no. 9743 (September 2010): 768–69. http://dx.doi.org/10.1016/s0140-6736(10)61373-6.
Full textSilva, Daniel G., J. Robert Gillespie, Ranae M. Ranade, Zackary M. Herbst, Uyen T. T. Nguyen, Frederick S. Buckner, Carlos A. Montanari, and Michael H. Gelb. "New Class of Antitrypanosomal Agents Based on Imidazopyridines." ACS Medicinal Chemistry Letters 8, no. 7 (June 29, 2017): 766–70. http://dx.doi.org/10.1021/acsmedchemlett.7b00202.
Full textDing, Dazhong, Yaxue Zhao, Qingqing Meng, Dongsheng Xie, Bakela Nare, Daitao Chen, Cyrus J. Bacchi, et al. "Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents." ACS Medicinal Chemistry Letters 1, no. 4 (April 6, 2010): 165–69. http://dx.doi.org/10.1021/ml100013s.
Full textRodríguez Arce, Esteban, Eugenia Putzu, Michel Lapier, Juan Diego Maya, Claudio Olea Azar, Gustavo A. Echeverría, Oscar E. Piro, et al. "New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents." Dalton Transactions 48, no. 22 (2019): 7644–58. http://dx.doi.org/10.1039/c9dt01317b.
Full textQiao, Zhitao, Qi Wang, Fenglong Zhang, Zhongli Wang, Tana Bowling, Bakela Nare, Robert T. Jacobs, et al. "Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents." Journal of Medicinal Chemistry 55, no. 7 (March 14, 2012): 3553–57. http://dx.doi.org/10.1021/jm2012408.
Full textPapadopoulou, Maria V., William D. Bloomer, Howard S. Rosenzweig, Ivan P. O'Shea, Shane R. Wilkinson, and Marcel Kaiser. "3-Nitrotriazole-based piperazides as potent antitrypanosomal agents." European Journal of Medicinal Chemistry 103 (October 2015): 325–34. http://dx.doi.org/10.1016/j.ejmech.2015.08.042.
Full textDissertations / Theses on the topic "Antitrypanosomal agents"
Clark, Rachel L. "The development of new broad spectrum antitrypanosomal agents." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415310.
Full textZulu, Ayanda Ignatia. "Synthesis and evaluation of arylpyrrole-chalcone hybrids as antiplasmodial and antitrypanosomal agents." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65268.
Full textSola, I., A. Artigas, M. C. Taylor, F. J. Perez-Areales, E. Viayna, M. V. Clos, B. Perez, Colin W. Wright, J. M. Kelly, and D. Muñoz-Torrero. "Synthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents." 2016. http://hdl.handle.net/10454/8940.
Full textCurrent drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, developed in our group as an anticholinesterasic agent, exhibits a submicromolar potency against Trypanosoma brucei and that its homo- and hetero-dimerization can result in to up to three-fold increased potency and selectivity. As an alternative strategy towards more potent smaller molecule anti-HAT agents, we have explored the introduction of ω-cyanoalkyl, ω-aminoalkyl, or ω-guanidinoalkyl chains at the primary amino group of huprine or the simplified 4-aminoquinoline analogue tacrine. Here, we describe the evaluation of a small in-house library and a second generation of newly synthesized derivatives, which has led to the identification of 13 side chain modified 4-aminoquinoline derivatives with submicromolar potencies against T. brucei. Among these compounds, the guanidinononyltacrine analogue 15e exhibits a 5-fold increased antitrypanosomal potency, 10-fold increased selectivity, and 100-fold decreased anticholinesterasic activity relative to the parent huprine Y. Its biological profile, lower molecular weight relative to dimeric compounds, reduced lipophilicity, and ease of synthesis, make it an interesting anti-HAT lead, amenable to further optimization to eliminate its remaining anticholinesterasic activity.
Wellcome Trust
Book chapters on the topic "Antitrypanosomal agents"
Kryshchyshyn, Anna, Danylo Kaminskyy, Philippe Grellier, and Roman Lesyk. "Thiazolidinone-Related Heterocyclic Compounds as Potential Antitrypanosomal Agents." In Azoles - Synthesis, Properties, Applications and Perspectives [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.91861.
Full textConference papers on the topic "Antitrypanosomal agents"
Suckling, Colin J., Fraser Scott, Abedawn Khalaf, Kirsten Gillingwater, Liam Morrison, Harry de Koning, Michael Barrett, and Federica Giordani. "Minor Groove Binders for DNA as Antitrypanosomal Agents: the Veterinary Context." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04647.
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