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Dissertations / Theses on the topic 'Antitrypanosomal'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Clark, Rachel L. "The development of new broad spectrum antitrypanosomal agents." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415310.

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2

Golisade, Abolfasl. "Polymerunterstützte Synthese von antitrypanosomal und anti-Malaria-aktiven Adenosinderivaten." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964083248.

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3

Mungongo, Singfrid Gasper. "The design, synthesis and biological evaluation of novel antitrypanosomal drugs." Thesis, University of Sunderland, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284073.

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4

Skaf, Joseph [Verfasser], and Ulrike [Gutachter] Holzgrabe. "Antileishmanial and antitrypanosomal compounds from \(Achillea\) \(fragrantissima\) / Joseph Skaf ; Gutachter: Ulrike Holzgrabe." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1166560244/34.

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5

Zulu, Ayanda Ignatia. "Synthesis and evaluation of arylpyrrole-chalcone hybrids as antiplasmodial and antitrypanosomal agents." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/65268.

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6

Rathnam, Rajendra Prasad. "Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/8110/.

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The 1,4-benzodiazepin-2-one motif has been taken as a privileged skeleton for making antitrypanosomal agents. A library of over sixty 1,4-benzodiazepin-2-one derivatives has been synthesised employing novel synthetic routes. These derivatives were characterised spectroscopically, by mass spectrometry, and by combustion analysis. Five derivatives were characterised, in the solid state, by single crystal X-ray crystallography. Biological assays of the library of compounds against Trypanosoma brucei brucei (T. b brucei) revealed a range of trypanocidal activities. A first generation library activ
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7

He, Shanshan. "Neglected Tropical Disease Chemotherapy: Mechanistic Characterization of Antitrypanosomal Dihydroquinolines and Development of a High Throughput Antileishmanial Screening Assay." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337980540.

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8

Maiwald, Franziska [Verfasser], and Conrad [Akademischer Betreuer] Kunick. "Synthese neuer 4-Azapaullone als potenziell antitrypanosomale Wirkstoffe / Franziska Maiwald ; Betreuer: Conrad Kunick." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175821853/34.

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9

Murebwayire, Sengabo. "Etudes des propriétés antiplasmodiales, antitrypanosomales et inhibitrices d'acétylcholinestérase de triclisia sacleuxii (Pierre) Diels "Menispermaceae"." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210506.

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Le paludisme, la maladie la plus dévastatrice des régions tropicales fait l’objet de nombreuses recherches ayant pour but de trouver des médicaments préventifs, du matériel de protection, de nouveaux traitements, des vaccins, …<p>Notre travail s’est inscrit dans la recherche des composés naturels actifs sur l’agent pathogène, le Plasmodium. Nos investigations phytochimiques et pharmacologiques ont porté sur Triclisia sacleuxii, une plante utilisée en médecine traditionnelle pour traiter diverses maladies dont deux parasitaires: la schistosomiase et l’ascardiose. Elle est aussi employée dans la
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10

Wendling, Ana Paula Barbosa. "Desempenho da pesquisa de anticorpos antiTrypanosoma cruzi, por citometria de fluxo, na monitoração precoce de cura pósterapêutica etiológica da doença de Chagas." Universidade Federal de Minas Gerais, 2006. http://hdl.handle.net/1843/ECJS-7GJN9A.

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Specific therapy of chronic Chagas disease aims mainly to reduce parasitemia, besides preventing and reducing symptoms. However, monitoring treatment efficacy still remains unclear due to the lack of laboratorial methods that could certify a complete parasitological cure. Currently, the cure criteria used by various researchers is based on repeated serological and parasitological negative tests. Several studies have shown that serology can remain positive for decades after specific therapeutics. The introduction of highly sensitive techniques such as specific antibodies detection by flow citom
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11

Bawn, Saw. "Studies on Antitrypanosomal Activity of Medicinal Plants." Doctoral thesis, 2010. http://hdl.handle.net/2115/42816.

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12

Skaf, Joseph. "Antileishmanial and antitrypanosomal compounds from \(Achillea\) \(fragrantissima\)." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-167841.

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This PhD thesis is dealing with the bioassay-guided fractionation of a dichloromethane extract of the aerial parts of Achillea fragrantissima with the aim of isolation and structure isolation of the antileishmanial and/or antitrypanosomal principles in the plant<br>Diese Dissertation beschäftigt sich mit der aktivitätsgeleiteten Fraktionierung eines Dichlormethanextrakts aus den oberirdischen Teilen von Achillea fragrantissima mit dem Ziel der Isolierung und Strukturaufklärung der anti-leishmanialen und/oder anti-trypanosomalen Verbindungen der Pflanze
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13

Golisade, Abolfasl [Verfasser]. "Polymerunterstützte Synthese von antitrypanosomal und anti-Malaria-aktiven Adenosinderivaten / vorgelegt von Abolfasl Golisade." 2001. http://d-nb.info/964083248/34.

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14

Sola, I., A. Artigas, M. C. Taylor, et al. "Synthesis and biological evaluation of N-cyanoalkyl-, Naminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents." 2016. http://hdl.handle.net/10454/8940.

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Yes<br>Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, developed in our group as an anticholinesterasic agent, exhibits a submicromolar potency against Trypanosoma brucei and that its homo- and hetero-dimerization can result in to up to three-fold increased potency and selectivity. As an alternative strategy towards more potent smaller molecule an
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15

PREVITI, SANTO. "Design, synthesis and biological evaluation of novel inhibitors of rhodesain, cysteine protease of Trypanosoma brucei rhodesiense, as antitrypanosomal agents." Doctoral thesis, 2017. http://hdl.handle.net/11570/3116817.

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Human African Trypanosomiasis (HAT), also known as sleeping sickness, is an endemic parasitic disease of sub-Saharan Africa, caused by two subspecies of protozoa of Trypanosoma genus: T. brucei gambiense and T. b. rhodesiense. This vector-borne disease is transmitted by the bite of tsetse fly (Glossina genus), with an estimated number of actual cases of 30000 each year. T. b. gambiense is widespread in central and western Africa, where induces a chronic form of the disease (95% of HAT cases). On the contrary, T. b. rhodesiense causes a rapid-onset, higher mortality rate, acute form of trypanos
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16

Inhoff, Oliver Dirk. "Die Trypanothionreduktase als Zielmolekül der antitrypanosomalen Wirkstoffentwicklung /." 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012972576&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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17

Tlhapi, Bafedile Dorcas. "Isolation and structure elucidation of bioctive compounds from Rauvolfia Caffra Sond." Diss., 2018. http://hdl.handle.net/11602/1259.

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MSc (Chemistry)<br>Department of Chemistry<br>Rauvolfia caffra Sond, a species of evergreen trees and shrubs in the dogbane family, (Apocynaceae), is used as a medicinal plant among traditional communities in many countries for the treatment of malaria, diabetes, coughs, gastrointestinal disturbances, skin infections, impotence, insomnia, diarrhoea, dysentery, scabies, worm infections, and both parasitic and microbial infections. Phytochemical studies have revealed that indole alkaloids are the major constituents of the stem bark. However, there are limited studies linking the compounds with t
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18

Merkel, Patrick [Verfasser]. "Isolierung und Identifizierung der hauptaktiven antitrypanosomalen Komponente des Viperngiftes von Eristocophis macmahoni und ihre Effekte auf Trypanosoma brucei / vorgelegt von Patrick Merkel." 2007. http://d-nb.info/983722927/34.

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