Relevant bibliographies by topics / Antitubercular activity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Antitubercular activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Antitubercular activity"

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HUSAIN, Asif, Aftab AHMAD, Anil BHANDARI, and Veerma RAM. "ANTITUBERCULAR ACTIVITY OF SOME NEWER 6-PYRIDAZINONE DERIVATIVES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 19, no. 19 (2011): 17–23. http://dx.doi.org/10.48141/sbjchem.v19.n19.2011.22_2011.pdf.

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Two series of 6-pyridazinone derivatives (17-30) were synthesized and evaluated for antitubercular activities against the Mycobacterium tuberculosis H37Rv strain. The results indicated that among the synthesized compounds, 5-( 4-hydroxy-3-methoxybenzyl}-3-phenyl-1,6-dihydro-6-pyridazinone (23) showed good antitubercular activity. Three more compounds, (18, 25 & 27) were significant in their antitubercular action. The present study reveals the antitubercular potential of 6-pyridazinones.
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Wächter, Gerald A., Susanne Valcic, Scott G. Franzblau, Enrique Suarez, and Barbara N. Timmermann. "Antitubercular Activity of Triterpenoids fromLippiaturbinata." Journal of Natural Products 64, no. 1 (2001): 37–41. http://dx.doi.org/10.1021/np000267b.

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Cardoso, Silvia H., Milena B. Barreto, Maria C. S. Lourenço, et al. "Antitubercular Activity of New Coumarins." Chemical Biology & Drug Design 77, no. 6 (2011): 489–93. http://dx.doi.org/10.1111/j.1747-0285.2011.01120.x.

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Kuneš, Jiřı́, Jaroslav Bažant, Milan Pour, Karel Waisser, Milan Šlosárek, and Jiřı́ Janota. "Quinazoline derivatives with antitubercular activity." Il Farmaco 55, no. 11-12 (2000): 725–29. http://dx.doi.org/10.1016/s0014-827x(00)00100-2.

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Gu, Jian-Qiao, Yuehong Wang, Scott G. Franzblau, Gloria Montenegro, and Barbara N. Timmermann. "Constituents ofSeneciochionophiluswith Potential Antitubercular Activity." Journal of Natural Products 67, no. 9 (2004): 1483–87. http://dx.doi.org/10.1021/np049831z.

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Tonelli, Michele, Federica Novelli, Bruno Tasso, et al. "Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines." Bioorganic & Medicinal Chemistry 22, no. 24 (2014): 6837–45. http://dx.doi.org/10.1016/j.bmc.2014.10.035.

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K, Ishwar Bhat, and Abhishek Kumar. "PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 247. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.17344.

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Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities. Chalcones with an enone group between two aromatic rings exhibit remarkable pharmacological activities such as antiinflammatory, antibacterial, antitumor, antifungal, and antimalarial activity. A series of pyrazolines from chalcones have been synthesized and evaluated for antitubercular and cytotoxic activity studies.Methods: Chalcones [3-substituted phenyl-1-(p-tolyl)prop-2-en-1-one] were synthesized from various substitut
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Jadhav, S. G., and S. R. Pattan. "SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES." INDIAN DRUGS 49, no. 06 (2012): 12–17. http://dx.doi.org/10.53879/id.49.06.p0012.

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A new series of substituted benzimidazole derivatives were synthesized by N-Mannich base reaction and the structures of these compounds have been established on the basis of spectral analysis. All the compounds have been screened for antitubercular activities. Some of these compounds have shown promising antitubercular activity.
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Anjani, Solankee, and Tailor Riki. "An efficient synthesis of some new chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus as potential antimicrobial and antitubercular agent." Chemistry International 2, no. 4 (2016): 189–200. https://doi.org/10.5281/zenodo.1471239.

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In an attempt to find a new class of antimicrobial and antitubercular agent, a new series of chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus were synthesized with appropriate chemical reagent. Chalcones (D1-D5) were synthesized by the classical Claisen-Schmidt condensation of substituted ketone (C) with variously substituted aldehydes via conventional method. Now treatment of chalcones with hydrazine hydrate/glacial acetic acid and guanidine hydrochloride/Alkali afforded the corresponding acetyl pyrazoline (E1-E5) and amino pyrimidine (F1-F5) derivatives respec
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Philip, Ifesinachi Anochie. "African Medicinal Plants that Can Control or Cure Tuberculosis." Int J Pharm Sci Dev Res 4, no. 1 (2018): 001–8. https://doi.org/10.17352/ijpsdr.000016.

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This review contains a compendium of medicinal plants in Africa that can control or cure tuberculosis. A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better. Information regarding the chemistry and pharmacology of plants leads to insight into their structure–activity relationship and potency. A well-defined strategy is required to exploit these phytomolecules as antitubercular drugs.
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Dissertations / Theses on the topic "Antitubercular activity"

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Coulibaly, Songuigama. "Synthèse et activité antituberculeuse de quelques dérivés de la 1,10-phénanthrolinone." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC407/document.

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La tuberculose est une infection humaine cosmopolite à transmission pulmonaire causée par Mycobactérium tuberculosis. Elle représente l'une des principales causes de mortalité dans le monde. La prise en charge thérapeutique de cette maladie est confrontée aujourd’hui à une forte pharmacorésistance des bacilles à la plupart des médicaments antituberculeux habituellement indiqués. Face à cette situation la recherche de nouvelles molécules plus efficaces échappant au phénomène de pharmacorésistance est encouragée par l'OMS. C'est dans ce contexte que nous avons conçu des dérivés de la 1,10-phénan
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Rudolph, Andrea Ines [Verfasser], Peter [Akademischer Betreuer] Imming, Martin [Akademischer Betreuer] Schlitzer, Ute [Akademischer Betreuer] Möllmann, and Andrea [Akademischer Betreuer] Sinz. "Antitubercular Benzothiazinones : synthesis, activity, properties and SAR / Andrea Ines Rudolph. Betreuer: Peter Imming ; Martin Schlitzer ; Ute Möllmann ; Andrea Sinz." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1059740028/34.

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Khouri, Inana Marie. "Synthèse et évaluation biologique de composés de série pyranodibenzofurane actifs sur Mycobacterium Tuberculosis." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P633.

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La tuberculose est une maladie infectieuse extrêmement contagieuse qui dans sa forme simple peut être soignée et guérie. Cependant, des formes multirésistantes aux traitements classiques ont récemment fait leur apparition et le développement de nouvelles molécules constitue donc un enjeu majeur de santé publique. Le 3,3-diméthyl-1,2-dihydro-3H-benzofuro[3,2-f][1]benzopyrane est un produit possédant une activité antituberculeuse marquée, y compris sur des lignées résistantes. L’objectif des travaux réalisés ici est la recherche de composés de puissance accrue et l’élucidation du mécanisme d’act
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Chiang, Chun-Ching, and 姜純靜. "Chemical Constituents and Antitubercular Activity from Fatoua pilosa." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/74320226382512584768.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Fatoua pilosa Gaud. (Moraceae) is a small perennial herb, which distributed in Taiwan, Philippine, Moluccas and New Guinea. In a series of studies on the active constituents of Formosan plants, the methanolic extract of the whole plant of this species showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. There are only three species of Fatoua in the world. The chemical constituents and bioactivities of Fatoua plants have never been conducted. The methanolic extract of whole plant of this species was partitioned into EtOAc and H2O-sol
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Huang, Wei-Ming, and 黃尉銘. "Chemical Constituents and Antitubercular activity from the Coptosapelta diffusa." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/02620399362746089391.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Coptosapelta diffusa Steenis (Thysanospermum diffusum Champ., Rubiaceae) is a woody lianas, distributed in Southern China, Ryukyu, and Taiwan in broad-leaved forests. The MeOH extract of its whole plant showed significant antitubercular activity against Mycobacterium tuberculosis H37Rv. and was partitioned into EtOAc, n-BuOH and H2O-soluble parts. Investigation of the EtOAc-soluble part by repeated column chromatography led to the isolation of thirty-four compounds, including fourteen triterpenoids: thysanolactone (1), coptosalactone A (2), coptosalactone B (3)
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Yang, Ping-Shin, and 楊秉勳. "Chemical Constituents and Antitubercular Activity from the Root ofBeilschmiedia erythrophloia." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/28757673115332773076.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Abstract Beilschmiedia erythrophloia Hay. (Lauraceae) is an evergreen tree, distributed in south China, Hainan, Ryukyus, and throughout the Taiwan. There are only two species of Beilschmiedia in Taiwan, the methanolic extract from the root of B. erythrophloia showed antitubercular activity, and its chemical constituents have never been conducted. The aim of this study is the isolation of chemical constituents and antitubercular activity from the methanolic extract of the root, which was partitioned to get EtOAc layer, H2O layer and insoluble part. Examination o
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Pan, Pei-Chi, and 潘霈淇. "Chemical Constituents and Antitubercular Activity from the Root of Litsea hypophaea." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02016555328008037466.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Litsea hypophaea Hay. (syn.: Actinodaphne pedicellata Hay., Litsea kostermansii Chang) (Lauraceae) is a small evergreen tree, endemic to Taiwan, distributed below 1,000 m in the broad-leaved forests. The methanolic extract of the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The chemical constituents have never been studied. Therefore, the aim of this study is the isolation of chemical constituents and its antitubercular activity. Investigation of the ethyl acetate-soluble layer of the root of this species
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Chu, Chin-Yi, and 朱晋億. "Chemical Constituents and Antitubercular Activity from the Root of Itea parviflora." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/82761083322049074416.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Itea parviflora Hemsl. (Saxifragaceae) is a shrub, endemic to Taiwan, common in forest at low to medium altitudes. The methanolic extract from the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. Past chemical study reported the flavonoids, including orientin, isoorientin, vitexin, and isovitexin detected by HPLC method in Itea virginica, I. parviflora and I. japonica, respectively. But their biological activities have not been conducted. The aim of this study is the isolation of chemical and antitubercular co
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Chien, Yu-Chieh, and 簡鈺潔. "Chemical Constituents and Antitubercular Activity from the Root of Ehretia longiflora." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/21177619265877218353.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>98<br>Ehretia longiflora Champ. ex Benth. (Boraginaceae) is a medium sized deciduous tree, distributed in south China, Indochina, and in forests from low elevations to 750 m of Taiwan. The methanolic extract of the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The aim of this study is to isolate the antitubercular active constituents from the root of this plant. Bioassay-guided fractionation of the ethyl acetate-soluble layer from the root of this species led to the isolation of thirty compounds, including one qu
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Wu, Ho-Chen, and 吳和澄. "Chemical Constituents and Antitubercular Activity from the Stem of Engelhardia roxburghiana." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/56857263430447803250.

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碩士<br>高雄醫學大學<br>藥學研究所<br>99<br>Engelhardia roxburghiana Wall. (Juglandaceae) is a deciduous tree, distributed in India, Indochina, SW China, and low to middle altitudes of Taiwan. Approximately 1300 species of Formosan plants have been screened for antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro, and E. roxburghiana was shown to be one of the active species. Previous investigations from our laboratory, eleven new compounds, and twenty-nine known compounds have been isolated from the root of this plant, among them, 2-methoxyjuglone, 3-methoxyjuglone, engelharquinone, e
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Book chapters on the topic "Antitubercular activity"

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"Antitubercular Agents: Quantitative Structure Activity Relationships and Drug Design." In Chemoinformatics: Directions Toward Combating Neglected Diseases, edited by Mushtaque S. Shaikh, Vijay M. Khedkar, and Evans C. Coutinho. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805183011201010069.

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Kayukova, Lyudmila, Umirzak Jussipbekov, and Kaldybay Praliyev. "Amidoxime Derivatives with Local Anesthetic, Antitubercular, and Antidiabetic Activity." In Heterocycles - Synthesis and Biological Activities. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90002.

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Appetecchia, Federico, Mariangela Biava, and Giovanna Poce. "Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents." In Flavonoids and Phenolics. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815079098122010008.

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Tuberculosis is a leading cause of mortality and morbidity worldwide, claiming 1.2 million deaths (including 208 000 people with HIV) and 10 million new cases in 2019. Current treatment suffers from significant shortcomings such as length, dosage regimen, toxicity, and resistance development to currently used medicines. The emergence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis is a major concern in controlling the disease. Therefore, there is an urgent need for new antitubercular drugs that are active against resistant strains, less toxic, and that act upon
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Jaiswal, Shalini. "Aqua Mediated Multicomponent Synthesis of N, O-Heterocycles and Biological Activity of Fused Isoxazole Derivatives." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch012.

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In the literature, several Drugs substituted with isoxazole ring shows various biological activities. The various drugs available in the market like sulfamethoxazole A, muscimol-B, ibotenic acid C, parecoxib-D, and leounomide contain the core structure of isoxazole. The use of water and phase transfer catalyst combined acted as a green attribute for the current approach. The current methodology has several benefits, such as a single-pot reaction, environmental friendliness, economic viability, wide substrate range, ease of operation, quick reaction time, simple workup process, and elevated yie
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Derangula, Samba Siva Raju, N. S. Muthiah, H. S. Somashekar, and E. Sukumar. "Hepatoprotective Activity of Pongamia pinnata Leaves on Antitubercular Drugs Induced Hepatotoxicity in Rats." In Pharmaceutical Research: Recent Advances and Trends Vol. 1. B P International, 2024. http://dx.doi.org/10.9734/bpi/prrat/v1/61.

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Palekar, Vikrant Sudhakar, and Kulbhushan A. Sasane. "Examining Biological Relevence of Thiazolo Thiadiazole and Thiazolo Thiazole Fused Heterocyles." In Advances in Bioinformatics and Biomedical Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7520-4.ch005.

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Aromatic Fused heterocycles containing Nitrogen (N) and Sulfur(S) has extraordinary bioactive behavior due to which they are attracting the interest of chemists worldwide &amp; thus used as a potential material in medicinal/pharmaceutical industries. The nitrogen-sulphur fused heterocycles attracting attention of the researchers due to number of biological and pharmacological activities and observed to exhibit extensive applications in drug discovery and development. The efforts are made to understand biological activity based on position of heteroatom &amp; the substituent present in 5-member
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Mahapatra, Monalisa, Kakarla Pakeeraiah, Suman Kumar Mekap, and Sudhir Kumar Paidesetty. "AZETIDINONE DERIVED DRUGS: BIOLOGICAL SIGNIFICANCE AND THEIR FUTURE SCOPE IN CHEMICAL SYNTHESIS." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 19. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bacs19p1ch2.

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Drug discovery and chemical synthesis have been globalizing the pharmaceutical market. The process of drug discovery takes along many stages of drug development viz., targeting a disease, repurposing an existing drug, conjugating obsolete drugs with natural compounds, searching for different receptors for specificity and rationality, and finally testing the toxicity before exposing it tothe clinical trial. This long path from targeting to clinical trial takes many efforts of scientists and chemists. When entering into the drug development core, the heterocyclic compounds were ruling the world
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K. Joshi, Kaushal. "Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors." In Chemistry with Pyridine Derivatives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106749.

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Pyridine is a valuable nitrogen based heterocyclic compound which is present not only in large number of naturally occurring bioactive compounds, but widely used in drug designing and development in pharmaceuticals as well as a precursor to agrochemicals and chemical-based industries. Pyridine derivatives bearing either formyl or amino group undergo Schiff base condensation reaction with appropriate substrate and under optimum conditions resulting in Schiff base as product which behave as a flexible and multidentate bioactive ligand. These Schiff bases are of great interest in medicinal chemis
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Conference papers on the topic "Antitubercular activity"

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Mangalagiu, Violeta, Dumitrela Diaconu, Costel Moldoveanu, et al. "Hybrid and chimeric nitrogen heterocycles with biological activity." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab01.

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Nitrogen heterocycles, especially azine and azole derivatives, are highly valuable scaffolds in medicinal chemistry, being the core components of a large variety of drugs with variously biological activity such as antiplasmodial and antimalarial, antitubercular, antibacterial, antifungal, anticancer, analgesic, antidepressant, anxiolytics, antihypertensive, anticoagulants, diuretics, etc. As a result, obtaining of such entities continues to arouse a strong interest from academia and industry. As part of our ongoing research in the area of nitrogen heterocyclic derivatives, we present herein so
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Monteiro, Alex, Marcus Scotti, and Luciana Scotti. "MOLECULAR MODELING OF NUCLEOTIDE DERIVATIVES OF 2.5-DIHYDROFURAN-2,5-DIOL FOR EVALUATION OF POTENTIAL ANTITUBERCULAR ACTIVITY." In MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition. MDPI, 2018. http://dx.doi.org/10.3390/mol2net-04-05917.

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