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Dissertations / Theses on the topic 'Antitubercular activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Coulibaly, Songuigama. "Synthèse et activité antituberculeuse de quelques dérivés de la 1,10-phénanthrolinone." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC407/document.

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La tuberculose est une infection humaine cosmopolite à transmission pulmonaire causée par Mycobactérium tuberculosis. Elle représente l'une des principales causes de mortalité dans le monde. La prise en charge thérapeutique de cette maladie est confrontée aujourd’hui à une forte pharmacorésistance des bacilles à la plupart des médicaments antituberculeux habituellement indiqués. Face à cette situation la recherche de nouvelles molécules plus efficaces échappant au phénomène de pharmacorésistance est encouragée par l'OMS. C'est dans ce contexte que nous avons conçu des dérivés de la 1,10-phénan
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2

Rudolph, Andrea Ines [Verfasser], Peter [Akademischer Betreuer] Imming, Martin [Akademischer Betreuer] Schlitzer, Ute [Akademischer Betreuer] Möllmann, and Andrea [Akademischer Betreuer] Sinz. "Antitubercular Benzothiazinones : synthesis, activity, properties and SAR / Andrea Ines Rudolph. Betreuer: Peter Imming ; Martin Schlitzer ; Ute Möllmann ; Andrea Sinz." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1059740028/34.

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3

Khouri, Inana Marie. "Synthèse et évaluation biologique de composés de série pyranodibenzofurane actifs sur Mycobacterium Tuberculosis." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P633.

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La tuberculose est une maladie infectieuse extrêmement contagieuse qui dans sa forme simple peut être soignée et guérie. Cependant, des formes multirésistantes aux traitements classiques ont récemment fait leur apparition et le développement de nouvelles molécules constitue donc un enjeu majeur de santé publique. Le 3,3-diméthyl-1,2-dihydro-3H-benzofuro[3,2-f][1]benzopyrane est un produit possédant une activité antituberculeuse marquée, y compris sur des lignées résistantes. L’objectif des travaux réalisés ici est la recherche de composés de puissance accrue et l’élucidation du mécanisme d’act
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4

Chiang, Chun-Ching, and 姜純靜. "Chemical Constituents and Antitubercular Activity from Fatoua pilosa." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/74320226382512584768.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Fatoua pilosa Gaud. (Moraceae) is a small perennial herb, which distributed in Taiwan, Philippine, Moluccas and New Guinea. In a series of studies on the active constituents of Formosan plants, the methanolic extract of the whole plant of this species showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. There are only three species of Fatoua in the world. The chemical constituents and bioactivities of Fatoua plants have never been conducted. The methanolic extract of whole plant of this species was partitioned into EtOAc and H2O-sol
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5

Huang, Wei-Ming, and 黃尉銘. "Chemical Constituents and Antitubercular activity from the Coptosapelta diffusa." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/02620399362746089391.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Coptosapelta diffusa Steenis (Thysanospermum diffusum Champ., Rubiaceae) is a woody lianas, distributed in Southern China, Ryukyu, and Taiwan in broad-leaved forests. The MeOH extract of its whole plant showed significant antitubercular activity against Mycobacterium tuberculosis H37Rv. and was partitioned into EtOAc, n-BuOH and H2O-soluble parts. Investigation of the EtOAc-soluble part by repeated column chromatography led to the isolation of thirty-four compounds, including fourteen triterpenoids: thysanolactone (1), coptosalactone A (2), coptosalactone B (3)
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6

Yang, Ping-Shin, and 楊秉勳. "Chemical Constituents and Antitubercular Activity from the Root ofBeilschmiedia erythrophloia." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/28757673115332773076.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Abstract Beilschmiedia erythrophloia Hay. (Lauraceae) is an evergreen tree, distributed in south China, Hainan, Ryukyus, and throughout the Taiwan. There are only two species of Beilschmiedia in Taiwan, the methanolic extract from the root of B. erythrophloia showed antitubercular activity, and its chemical constituents have never been conducted. The aim of this study is the isolation of chemical constituents and antitubercular activity from the methanolic extract of the root, which was partitioned to get EtOAc layer, H2O layer and insoluble part. Examination o
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7

Pan, Pei-Chi, and 潘霈淇. "Chemical Constituents and Antitubercular Activity from the Root of Litsea hypophaea." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02016555328008037466.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Litsea hypophaea Hay. (syn.: Actinodaphne pedicellata Hay., Litsea kostermansii Chang) (Lauraceae) is a small evergreen tree, endemic to Taiwan, distributed below 1,000 m in the broad-leaved forests. The methanolic extract of the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The chemical constituents have never been studied. Therefore, the aim of this study is the isolation of chemical constituents and its antitubercular activity. Investigation of the ethyl acetate-soluble layer of the root of this species
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8

Chu, Chin-Yi, and 朱晋億. "Chemical Constituents and Antitubercular Activity from the Root of Itea parviflora." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/82761083322049074416.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Itea parviflora Hemsl. (Saxifragaceae) is a shrub, endemic to Taiwan, common in forest at low to medium altitudes. The methanolic extract from the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. Past chemical study reported the flavonoids, including orientin, isoorientin, vitexin, and isovitexin detected by HPLC method in Itea virginica, I. parviflora and I. japonica, respectively. But their biological activities have not been conducted. The aim of this study is the isolation of chemical and antitubercular co
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9

Chien, Yu-Chieh, and 簡鈺潔. "Chemical Constituents and Antitubercular Activity from the Root of Ehretia longiflora." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/21177619265877218353.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>98<br>Ehretia longiflora Champ. ex Benth. (Boraginaceae) is a medium sized deciduous tree, distributed in south China, Indochina, and in forests from low elevations to 750 m of Taiwan. The methanolic extract of the root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The aim of this study is to isolate the antitubercular active constituents from the root of this plant. Bioassay-guided fractionation of the ethyl acetate-soluble layer from the root of this species led to the isolation of thirty compounds, including one qu
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10

Wu, Ho-Chen, and 吳和澄. "Chemical Constituents and Antitubercular Activity from the Stem of Engelhardia roxburghiana." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/56857263430447803250.

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碩士<br>高雄醫學大學<br>藥學研究所<br>99<br>Engelhardia roxburghiana Wall. (Juglandaceae) is a deciduous tree, distributed in India, Indochina, SW China, and low to middle altitudes of Taiwan. Approximately 1300 species of Formosan plants have been screened for antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro, and E. roxburghiana was shown to be one of the active species. Previous investigations from our laboratory, eleven new compounds, and twenty-nine known compounds have been isolated from the root of this plant, among them, 2-methoxyjuglone, 3-methoxyjuglone, engelharquinone, e
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11

Wu, Ming-Chun, and 吳明純. "Chemical Constituents and Antitubercular Activity fromthe Stem and Root of Pisonia aculeata." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/56715518274439519266.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Pisonia aculeata L. (Nyctaginaceae) is a scandent shrub with pricks, which distributed in south China, the Ryukyus, India, Malaysia, Indonesia and in thickets along the seashores and open forests at low elevations in the south and east of Taiwan. In a series of studies on the active constituents of Formosan plants, the MeOH extract of the combined stem and root of this plant showed antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro. The chemical constituents of P. aculeata have never been conducted. 　　The MeOH extract of the combined stem
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12

Huang, Hung-Yi, and 黃弘宜. "Chemical Constituents and Antitubercular Activity from the Root Wood of Zanthoxylum wutaiense." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/64902516771378440604.

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碩士<br>高雄醫學大學<br>天然藥物研究所碩士班<br>94<br>Zanthoxylum wutaiense Chen (Rutaceae) is a prickle shrub, endemic in Taiwan and known only from Pintung County. In preliminary screening, the methanolic extract of the root wood showed antitubercular activity against Mycobacterium tuberculosis 90-221387 in vitro. Investigation of the chloroform-soluble fraction of the root wood led to the isolation of fifty-three compounds. These compounds were identified as wutaiensyl methyl ether (1), demethoxywutaiensyl methyl methylether (2), methyl wutaiensate (3), methyl demethoxywutaiensate (4), wutaiensal (5), methyl
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13

Chen, Yi-Shiou, and 陳怡秀. "Antitubercular Activity and Chemical Constituents from the Stems of Formosan Actinidia callosa var. callosa." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/03954192430230170848.

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碩士<br>高雄醫學大學<br>天然藥物研究所碩士班<br>94<br>Abstract Actinidia callosa Lindl. var. callosa (Actinidiaceae) is a tall climbing tree, and MeOH extract of its stems showed significant antitubercular activity against Mycobacterium tuberculosis 90-221387 (clinical isolate) in vitro. The MeOH extract was partitioned into n-hexane-, CHCl3-, n-BuOH and H2O-soluble fractions, and showed significant antitubercular activity except n-BuOH-soluble fraction. The investigation of the n-hexane-soluble fraction led to the isolation of twenty-eight compounds, including sixteen triterpenoids: ??-amyrinyl palmitate (1),
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14

Chikhale, R., S. Menghani, R. Babu, et al. "Development of selective DprE1 inhibitors: Design, synthesis, crystal structure and antitubercular activity of benzothiazolylpyrimidine-5-carboxamides." 2015. http://hdl.handle.net/10454/7338.

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No<br>Decaprenylphosphoryl-b-d-ribose 20-epimerase (DprE1) is a potential drug target for development of antitubercular agents. Structure based drug discovery approach yielded twenty novel derivatives of benzothiazolylpyrimidine-5-carboxamides (7a–t) which were synthesised by three component one pot reaction involving benzothiazolyl oxobutanamide, thiourea and substituted aromatic benzaldehydes. These derivatives were evaluated for antitubercular activity to determine MIC and compound 7a, 7e, 7f and 7o were found to be potentially active against Mycobacterium tuberculosis (H37Rv). Log P of the
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15

Chang, Chun-Wei, and 張峻維. "Part I. Chemical Constituents and Antitubercular Activity from the Whole Plant of Amischotolype hispidaPart II. Secondary Metabolites and Antiinflammatory Activity of an Endophytic Fungus, Hypoxylon investiens." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/27687169637023561951.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>101<br>Part I: Amischotolype hispida (Less.＆ A. Rich.) Hong (Commelinaceae) is a perennial herb, distributed over forest floors at low to middle altitudes throughout Taiwan. There are 20 species of Amischotolype genus around the world and only one species in Taiwan. The methanolic extract of the whole plant of this plant was shown with antitubercular activity. However, the phytochemistry and biological activities of Amischotolype genus have never been conducted. Bioassay-guided fractionation of the active ethyl acetate-soluble layer has led to the isolation of four n
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