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Journal articles on the topic 'Antitubercular treatment'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Zitko, Jan, and Martin Doležal. "Old Drugs and New Targets as an Outlook for the Treatment of Tuberculosis." Current Medicinal Chemistry 25, no. 38 (2019): 5142–67. http://dx.doi.org/10.2174/0929867324666170920154325.

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Background: Despite of the globally positive trends in the epidemiology of tuberculosis, the increasing rates of drug-resistant strains are urging to introduce new antituberculars into clinical practice. Development of a new chemical entity from hit to marketed drug is an extremely time and resources consuming process with uncertain outcome. Repurposing of clinically used drugs can be a cheaper alternative to develop new drugs effective in the treatment of tuberculosis. Objective: To extract the latest information on new mechanisms of action described or proposed for clinically used antituberc

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Ayushi, Praveen Jaiswal Mr., Shaneza Aman Ms., Ashok Kumar Sharma Mr., Purushottam Prajapati Mr., and Mehul Kumar Choudhary Mr. "A NEW DRUG- VXc-486 TUBERCULOSIS TREATMENT: A REVIEW." International Journal of Current Pharmaceutical Review and Research 13, no. 2 (2021): 24–27. https://doi.org/10.5281/zenodo.12667297.

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Tuberculosis (TB) is a communicable disorder from time to time because of themicroorganism mycobacterium tuberculosis (MTB). Antitubercular agent acts as inhibitingthe growth of Mycobacterium tuberculosis. Antitubercular agents specifically act with the aidof using inhibit the growth of microorganism with the aid of using cell wall synthesisinhibition. VXc-486 is a powerful antitubercular drug belonging with aminobenzimidazolecategory. The novel aminobenzimidazole, VXc-486, which targets gyrase B, potently inhibitsa couple of drug-sensitive isolates and drug-resistant isolates of Mycobacterium

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3

Dion Pratama Puja, Putu. "Treatment of Pulmonary TB Patients on Antitubercular Medications with Transaminitis." International Journal of Science and Research (IJSR) 11, no. 5 (2022): 725–28. http://dx.doi.org/10.21275/sr22505082555.

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4

Chaudhary, Meenakshi. "Butterfly pattern hypopigmentation with antitubercular treatment." International Journal of Basic & Clinical Pharmacology 3, no. 2 (2014): 1. http://dx.doi.org/10.5455/2319-2003.ijbcp20140434.

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5

Likhitha, B. K., Shreeshail Anjutagi, Keertivardhan D. Kulkarni, and Madhav Mahawar. "Challenges faced during antitubercular therapy." BLDE University Journal of Health Sciences 9, no. 2 (2024): 184–86. https://doi.org/10.4103/bjhs.bjhs_131_24.

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Abstract This case report discusses regarding a 48-year-old male with drug-sensitive tuberculosis (TB) and alcoholic liver disease, who experienced significant side effects during antitubercular therapy. The patient presented with peripheral neuropathy, deranged liver function, elevated uric acid levels, gastritis, and psychological distress during the treatment period. Modifications included the change of regimen and the symptomatic treatment of the associated side effects with regular liver function monitoring. Comprehensive patient education and counseling were provided to enhance adherence

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Olga Mykolaivna Shvets, Olga Stanislavna Shevchenko, and Hanna Leonidivna Stepanenko. "INSULIN RESISTANCE IN DRUG-SUSCEPTIBLE PULMONARY TUBERCULOSIS PATIENTS DURING THE FIRST MONTH OF ANTITUBERCULAR TREATMENT." International Academy Journal Web of Scholar 1, no. 8(38) (2019): 13–17. http://dx.doi.org/10.31435/rsglobal_wos/31082019/6650.

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   The study was aimed to investigate insulin resistance development in drug-susceptible newly diagnosed pulmonary tuberculosis patients. Those patients who developed insulin resistance during the 30 days of antitubercular therapy have expressed metabolic changes, that may be associated with impaired liver function due to the toxic effects of antitubercular drugs.  

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7

Kar, Sidhartha S., and Cinu A. Thomas. "Strategically Placed Trifluoromethyl Substituent in the Realm of Antitubercular Drug Design." Current Drug Therapy 14, no. 2 (2019): 114–23. http://dx.doi.org/10.2174/1574885513666180906101732.

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Background:Fluorinated substituents have played, and continue to play an important role in antitubercular drug design. Nonetheless, previous works have indicated that organofluorines like –F, CF3, -OCF3, and CHF2 etc have been used to modulate the pharmacodynamic and pharmacokinetic behaviour of antitubercular agents. Among the fluorinated groups, trifluoromethyl (-CF3) substituent is a very familiar pharmacophore used widely in antitubercular research.Objective:This review assesses the development of selected trifluoromethyl group bearing antitubercular agents that are either in treatment or

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8

Yadav, Gulab S., Vinod K. Jangid, and Brij B. Mathur. "Study of various reasons for interruption of anti-tubercular treatment in patients of tuberculosis reporting to tertiary care center of west Rajasthan." International Journal of Research in Medical Sciences 7, no. 6 (2019): 2220. http://dx.doi.org/10.18203/2320-6012.ijrms20192542.

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Background: Tuberculosis is a major cause of death in India. Premature cessation of treatment in tuberculosis patient is a leading cause for developing MDR (multidrug resistant tuberculosis) as well as a major threat to control programs. Despite the easy approach and free of cost, availability to antitubercular medicines the interruptions of the treatment are still on a high. So, we analyzed such various reasons leading to interrupt the antitubercular treatment.Methods: Total 150 patients who interrupted the antitubercular treatment, were interviewed with a predesigned questionnaire and the re

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Li, Chungen, Yunxiang Tang, Zitai Sang, et al. "Discovery of napabucasin derivatives for the treatment of tuberculosis." MedChemComm 10, no. 9 (2019): 1635–40. http://dx.doi.org/10.1039/c9md00295b.

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10

Karthik, G. S., Kritika Sahay, Kiranmai Ismal, Swarnalata Gowrishankar, Nikita Sahay, and Manisha Sahay. "A Case Series of Bile Cast Nephropathy-induced Rapidly Progressive Renal Failure." Osmania Journal of Medical Research 1, no. 1 (2024): 25–28. http://dx.doi.org/10.4103/ojmr.ojmr_19_23.

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Abstract A 45-year-old male presented to the hospital with symptoms of left inguinal swelling, which showed granulomatous adenitis on fine-needle aspiration cytology. He was diagnosed with tuberculous adenitis, for which he was started on antitubercular treatment. After 15 days of antitubercular treatment, the patient developed deranged renal parameters, with serum creatinine of 8.8 mg/dL while serum bilirubin rose to 7.4 mg/dL. The patient was oliguric and underwent four sessions of hemodialysis. Following this, a renal biopsy was done, which showed normal glomeruli with tubular casts that we

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11

Hokama, Akira, Yuiko Oishi, Erika Koga, Sayuri Takehara, and Jiro Fujita. "Paradoxical Reaction to Antitubercular Treatment Causing Colonic Obstruction." Chonnam Medical Journal 58, no. 1 (2022): 52. http://dx.doi.org/10.4068/cmj.2022.58.1.52.

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12

Vyas, Aniruddha, K. Rajeshwari, Sumod Kurien, Vimal Mehta, Nagaraj Pandarikar, and Sanjay Tyagi. "An unusual cardiac mass resolving with antitubercular treatment." Annals of Pediatric Cardiology 7, no. 3 (2014): 204. http://dx.doi.org/10.4103/0974-2069.140849.

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13

De, Sajal. "Effect of Antitubercular Treatment on Tumorous Endobronchial Tuberculosis." Journal of Bronchology & Interventional Pulmonology 18, no. 2 (2011): 171–75. http://dx.doi.org/10.1097/lbr.0b013e318217ccea.

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14

Das, Saibal, Sapan Kumar Behera, Kirubakaran Ramakrishnan, Mahalakshmi Ganesapandian, Hemachandren Munuswamy, and Sandhiya Selvarajan. "A complex interaction between antitubercular treatment and acenocoumarol." European Journal of Clinical Pharmacology 76, no. 1 (2019): 133–35. http://dx.doi.org/10.1007/s00228-019-02776-0.

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15

Ichai, Philippe, Faouzi Saliba, Fadi Antoun, et al. "Acute liver failure due to antitubercular therapy: Strategy for antitubercular treatment before and after liver transplantation." Liver Transplantation 16, no. 10 (2010): 1136–46. http://dx.doi.org/10.1002/lt.22125.

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16

Kalbhande, Dr Jayesh. "Conservative management of tubercular intestinal obstruction with antitubercular drugs and steroid." Journal of Medical Science and clinical Research 12, no. 02 (2024): 23–27. http://dx.doi.org/10.18535/jmscr/v12i02.05.

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Objective: Tubercular intestinal obstruction is a challenging condition often necessitating surgical intervention. This case study aims to evaluate the effectiveness of conservative management, including antitubercular therapy, short-course steroids, and dietary modifications, in resolving acute and complete intestinal obstruction caused by tuberculosis. Case Description: A 17-year-old malnourished male presented with acute abdominal pain, vomiting, and constipation. Imaging revealed mid-ileal intestinal obstruction due to tuberculosis. Conservative management, involving intravenous antibiotic

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17

Dzheliev, I. Sh, and B. M. Lolaeva. "COMPLICATION OF THE PRIMARY ANTITUBERCULAR VACCINATION." Journal of Volgograd State Medical University 74, no. 2 (2020): 118–22. http://dx.doi.org/10.19163/1994-9480-2020-2(74)-118-122.

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The aim of the study was to determine the causes and frequency of complications of TB vaccination in newborns, tactics of their treatment and prevention measures. The subject of the study were patients with chronic complications of tuberculosis vaccination: regional lymphadenitis, superficial ulcer, cold abscess, keloid scar, osteo-myelitis. Analysis of morbidity carried out in the Republic of North Ossetia – Alania from 2010 to 2018. A direct correlation of complications with the level of brevemente children with tuberculosis, a decrease in reactivity and change them-munna status of mother an

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18

Chemello, Davide, Maddalena Albertini, Johanna Chester, et al. "Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review." Microorganisms 13, no. 6 (2025): 1283. https://doi.org/10.3390/microorganisms13061283.

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Bacillus Calmette–Guerin (BCG) central nervous system (CNS) infections are one of the rarest complications following BCG exposure. A 77-year-old male, with bladder cancer previously treated with BCG instillation, presented with fever, confusion, and brain magnetic resonance imaging (MRI) consistent with encephalitis one month after the last BCG instillation. Cerebrospinal fluid (CSF) showed marked hypoglycorrhachia, hyperproteinorrachia, and lymphocytic pleocytosis. Despite CSF culture negativity, the presentation was considered suggestive of BCG-related encephalitis, and the empirical standar

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Koul, Ajaz Nabi. "Paradoxical Reactions in Tuberculosis : Clinicians Burnout." JMS SKIMS 21, no. 2 (2019): 127–28. http://dx.doi.org/10.33883/jms.v21i2.349.

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We want to make our observations regarding worsening of clinical and radiologic features in a patient of potts spine after institution of antitubercular therapy. The index case is 34 year old male presented with pain in lower back and fever for past many months. Clinical examination revealed febrile, weak and anxious person with normal clinical examination. His investigations revealed Hb 11.8 mg/dl, TLC, DLC, platelet count normal. ESR was 52 mm at 1st hour and Mantoux was 12 mm at 72 hrs. CXR, USG abdomen were normal. Brucella agglutination titre was not suggestive for endemic area. Retrovira

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20

Veluthat, Chitra, Kavitha Venkatnarayan, Priyadarshini Padaki, and Uma Maheswari Krishnaswamy. "Case of melioidosis misdiagnosed as pulmonary tuberculosis." BMJ Case Reports 14, no. 5 (2021): e242499. http://dx.doi.org/10.1136/bcr-2021-242499.

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Melioidosis is an endemic infection caused by Burkholderia pseudomallei predominantly reported in the coastal parts of India. A 19-year-old male student with no comorbidities presented with features suggestive of pneumonia. He was initiated on antitubercular treatment empirically elsewhere. However, due to lack of response to therapy diagnosis was revisited. Microbiological investigations were unyielding initially. Despite antitubercular treatment, he presented with complications of pneumonia and was diagnosed to have melioidosis. He was initiated on appropriate antibiotics for the intensive a

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Jalan, Shyam, Ashish Anjankar, and Mayur Wanjari. "Case Report: Abdominal tuberculosis presenting as abdominal mass." F1000Research 12 (July 21, 2023): 867. http://dx.doi.org/10.12688/f1000research.138592.1.

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Among the most prevalent types of extrapulmonary TB is abdominal (TB). The diagnosis of abdominal TB is difficult. This disorder is thought to be a good imitator of other abdominal illnesses. To reduce morbidity and mortality, early diagnosis, antitubercular medication start-up, and surgical treatment are crucial. Only seldom is surgery necessary because most patients benefit from antitubercular therapy. Imaging is crucial to the diagnosis and care of these individuals. The following patient, aged about 53 years old female, complained of stomach pain, vomiting, loss of appetite, and weight los

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22

Nene, Amit S., Manas Mengar, Onkar H. Pirdankar, Rajlaxmi Virkar, Pushpanjali Badole, and Smitesh Shah. "Isoniazid-induced Choroidal Effusion: A Rare Presentation." Delhi Journal of Ophthalmology 34, no. 2 (2024): 149–50. https://doi.org/10.4103/dljo.dljo_5_24.

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The purpose is to report a rare case of isoniazid-induced choroidal effusion. A 62-year-old female who was under antitubercular treatment with isoniazid came with chief complains of diminution of vision in both eyes. Clinical evaluation, fundus photos, and B scan revealed choroidal detachment in both eyes. Discontinuation of antitubercular drug and posterior subtenon’s triamcinolone injection resulted in resolved choroidals. Health education about possible ocular side effects of isoniazid and periodic ophthalmic screening should be considered.

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23

A, Sontakke, Pati R, and Ali S. "Adverse Drug Reactions in Intensive / Initial Phase of Antitubercular Treatment in Patients of Tuberculosis." International Journal of Science and Research (IJSR) 13, no. 10 (2024): 1745–51. http://dx.doi.org/10.21275/sr241021223722.

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24

Lv, Qingzhi, Dun Wang, Zimeng Yang, et al. "Repurposing antitubercular agent isoniazid for treatment of prostate cancer." Biomaterials Science 7, no. 1 (2019): 296–306. http://dx.doi.org/10.1039/c8bm01189c.

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25

Kirubanandam, A., V. Arunshankar, and A. Mahilmaran. "Recurrent tuberculosis due to subtherapeutic levels of antitubercular treatment." Journal of Association of Pulmonologist of Tamil Nadu 3, no. 3 (2020): 142. http://dx.doi.org/10.4103/japt.japt_6_21.

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26

Makwana, Mitul Jagdishbhai, Devang A. Rana, Krisha Panchal, and Sapna D. Gupta. "Antitubercular treatment-induced chronic progressive sensory-motor polyneuropathy with optic neuropathy." National Journal of Pharmacology and Therapeutics 2, no. 1 (2024): 51–53. http://dx.doi.org/10.4103/njpt.njpt_7_24.

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Polyneuropathy is a major complication in tuberculosis (TB) patients associated with various causes, including comorbid conditions and antitubercular medications, particularly involving drugs such as isoniazid (INH) and ethambutol. INH interferes with pyridoxine synthesis, leading to sensory peripheral neuropathy, and presents with symptoms such as tingling, burning, numbness, and difficulty in walking. Ethambutol, on the other hand, is associated with optic neuropathy, presenting as bilateral and symmetrical visual field abnormalities. We report a case of a 39-year-old male with TB undergoing

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Stephanie, Filia, Mutiara Saragih, and Usman Sumo Friend Tambunan. "Recent Progress and Challenges for Drug-Resistant Tuberculosis Treatment." Pharmaceutics 13, no. 5 (2021): 592. http://dx.doi.org/10.3390/pharmaceutics13050592.

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Control of Mycobacterium tuberculosis infection continues to be an issue, particularly in countries with a high tuberculosis (TB) burden in the tropical and sub-tropical regions. The effort to reduce the catastrophic cost of TB with the WHO’s End TB Strategy in 2035 is still obstructed by the emergence of drug-resistant TB (DR-TB) cases as result of various mutations of the MTB strain. In the approach to combat DR-TB, several potential antitubercular agents were discovered as inhibitors for various existing and novel targets. Host-directed therapy and immunotherapy also gained attention as the

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Kumar, M. Ravish, Praveen Kumar Doddamani, Lavanya S. Peter, Prashant Parandekar, and Shrinivas Reddy. "Pattern of Mutations in Rifampicin Resistance (rpoB) Gene and Analysis of Rifampicin Indeterminate Result in Tuberculosis Detected by Xpert MTB/RIF Assay in Kalaburagi, India." Journal of Pure and Applied Microbiology 18, no. 2 (2024): 1290–96. http://dx.doi.org/10.22207/jpam.18.2.49.

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Tuberculosis (TB) is a serious disease that has been observed since ancient times. In the mid-to late-20th century, the main clinical approach to this disease involved focusing on its diagnosis, prevention, and treatment. However, in the 21st century, the focus has shifted toward the diagnosis and treatment of drug-resistant TB. With the use of the Xpert MTB/RIF assay at the frontlines in India, interpreting indeterminate results to treatment with rifampicin, an antitubercular drug, can be challenging. This is further exacerbated by a lack of knowledge regarding mutation frequency in antituber

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Davies-Bolorunduro, Olabisi Flora, Abraham Ajayi, Isaac Adeyemi Adeleye, Alfinda Novi Kristanti, and Nanik Siti Aminah. "Bioprospecting for antituberculosis natural products – A review." Open Chemistry 19, no. 1 (2021): 1074–88. http://dx.doi.org/10.1515/chem-2021-0095.

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Abstract There has been an increase in the reported cases of tuberculosis, a disease caused by Mycobacterium tuberculosis, which is still currently affecting most of the world’s population, especially in resource-limited countries. The search for novel antitubercular chemotherapeutics from underexplored natural sources is therefore of paramount importance. The renewed interest in studies related to natural products, driven partly by the growing incidence of MDR-TB, has increased the prospects of discovering new antitubercular drug leads. This is because most of the currently available chemothe

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Brewer, Christopher Trent, Kiran Kodali, Jing Wu, Timothy I. Shaw, Junmin Peng, and Taosheng Chen. "Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid." Cells 9, no. 7 (2020): 1654. http://dx.doi.org/10.3390/cells9071654.

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Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of hPXR-mediated hepatotoxicity and the systemic toxicity of antitubercular drugs. The antitubercular drug isoniazid plays a role in such pathologic states as acute intermittent porphyria, anemia, hepatotoxicity, hypercoagulable states (deep vein thrombosis, pulmonary embolism, or ischemic stroke), pellagra (vitamin B3 deficiency), peripheral neuropathy, and vitamin B6 deficiency. Howe

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Karthikeyan, VS, SC Sistla, D. Ram, et al. "Spontaneous choledochoduodenal fistula with tuberculous duodenal ulceration." Annals of The Royal College of Surgeons of England 96, no. 1 (2014): e01-e02. http://dx.doi.org/10.1308/003588414x13824511649292.

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Spontaneous choledochoduodenal fistulas (CDFs) are rare. The most common aetiology is penetrating duodenal ulcers, observed in 80% of cases. Even in areas where acid peptic disease is common, tuberculosis should be considered as a cause, especially in developing countries like India, where tuberculosis is common. The management of CDF due to acid peptic disease is predominantly surgical while healing of tuberculous CDF has been reported with antitubercular treatment. A preoperative diagnosis of tuberculous CDF by endoscopic biopsy from the duodenal ulcer or image guided fine needle aspiration

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Basuri, TS, and Ranjit Mohapatra. "Critical review on analytical detection of first line and second line anti tubercular agent by various modern analytical method." IP International Journal of Comprehensive and Advanced Pharmacology 9, no. 2 (2024): 91–97. http://dx.doi.org/10.18231/j.ijcaap.2024.014.

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Tuberculosis is a chronic inflammatory, granulomatous bacterial infectious disease caused by Mycobacterium tuberculosis. About 10 million people worldwide are ill with MTB in 2018, 5.7 million are males, 3.2 million are females and 1.1 million are infants, 1.6 million died from the disease. This article includes epidemiology, classification, pathogenesis, diagnosis and treatment of Tuberculosis. It includes the drug profile of antitubercular agents such as isoniazid, pyrazinamide, ethambutol, rifampicin, paraminosalicylic acid, thiacetazone, ethionamide, kanamycin, amikacin. cycloserine, viomy

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Saxena, Anil Kumar, and Anamika Singh. "Mycobacterial tuberculosis Enzyme Targets and their Inhibitors." Current Topics in Medicinal Chemistry 19, no. 5 (2019): 337–55. http://dx.doi.org/10.2174/1568026619666190219105722.

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Tuberculosis (TB) still continues to be a major killer disease worldwide. Unlike other bacteria Mycobacterium tuberculosis (Mtb) has the ability to become dormant within the host and to develop resistance. Hence efforts are being made to overcome these problems by searching for new antitubercular agents which may be useful in the treatment of multidrug-(MDR) and extensively drugresistant (XDR) M. tuberculosis and shortening the treatment time. The recent introduction of bedaquiline to treat MDR-TB and XDR-TB may improve the status of TB treatment. The target enzymes in anti-TB drug discovery p

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Priyanka, Bansal, Mishra Sukriti, and Ambey Ravi. "Weight Gain Pattern in Children Below 14 Years Undergoing Antitubercular Therapy." International Journal of Toxicological and Pharmacological Research 13, no. 5 (2023): 100–105. https://doi.org/10.5281/zenodo.11207003.

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In India, an estimated 3.33 lakh children in the 0–14 years’ age group become ill with Tuberculosis (TB) each year. TB is one of the most pressing health problems nationally. Weight gain during treatment is the main indicator of good treatment outcome, but there is no adequate information on weight gain pattern and the factors that affect weight gain in pediatrics population. <strong>Objective:</strong> To evaluate the weight gain in pediatric patients undergoing antitubercular therapy and to analyse the various factors associated with weight gain in pediatric patients un

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Kakadiya, Monika, Singh Ramiya, Malleshappa Noolvi, and T. Y. Pasha. "Designing of Nitroimidazole Derivatives as a Promising Target for Treatment of Tuberculosis." Asian Journal of Organic & Medicinal Chemistry 4, no. 2 (2019): 55–60. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p173.

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Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, with high level of mortality worldwide, currently with approximately 10 million cases of tuberculosis. These rate of incidence are due to several factors such as bacterial resistance, AIDS, latent tuberculosis that reoccur in patient. Deazaflavin dependent nitroreductase (Ddn) is an emerging target in the field of antitubercular agent. Ddn catalyses the reduction of nitroimidazoles resulting in intra-cellular release of lethal reactive nitrogen species. Nitroimidazole class drug- delamanid and pretonamid are used in th

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Goldman, Jennifer, and Susan Abdel-Rahman. "Pharmacology of Mycobacterial Drugs in Children." Journal of Pediatric Infectious Diseases 13, no. 02 (2017): 101–12. http://dx.doi.org/10.1055/s-0037-1606602.

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AbstractTo effectively treat tuberculosis (TB), optimization of therapy guided by an understanding of pharmacokinetic-pharmacodynamic principles represents the strategy most likely to influence favorable patient outcomes. However, challenges are often encountered during TB treatment given the concomitant administration of multiple drugs, some with poorly defined therapeutic targets, for prolonged durations. Treatment is further complicated in children as many antitubercular drugs have not been extensively studied in the pediatric population where the impact of human development on drug disposi

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Gupta, Rahul Kumar, Sammi Pundir, Mansi Kala, Avriti Baveja, Pranshul Rawat, and Anuradha Khandelwal. "Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report." Indian Journal of Allergy, Asthma and Immunology 39, no. 1 (2025): 29–32. https://doi.org/10.4103/ijaai.ijaai_64_24.

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Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder which occurs due to excessive immune response and high cytokine levels leading to tissue damage and organ failure. HLH can be primary and secondary. The etiology and presentation of secondary HLH remain diverse. Treatment of secondary HLH includes management of primary conditions and immunosuppressives. Several cases of secondary HLH due to tuberculosis (TB) have been reported in the past although their management beyond antitubercular therapy and follow-up was not reported. Here, we present a rare case report of

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Bhardwaj, Parul, Anju Bala, and Shivbrat . "Isoniazid Induced Unilateral Gynecomastia: A Rare Case Report." International Journal of Science and Healthcare Research 6, no. 2 (2021): 50–52. http://dx.doi.org/10.52403/ijshr.202104010.

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Gynecomastia refers to glandular enlargement of male breast. It can be physiological, pathological, pharmacological and idiopathic. The present case report describes a case of isoniazid induced gynecomastia. Keywords: Gynecomastia, antitubercular treatment (ATT), isoniazid.

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Choudhary, Narendra Singh, Vikas Deswal, Swapnil Dhampalwar, Saurabh Mishra, Dheeraj Gautam, and Neeraj Saraf. "Hepatic Histoplasmosis Masquerading as Cirrhosis and Portal Hypertension: A Case Report." Journal of Gastrointestinal Infections 12, no. 02 (2022): 121–23. http://dx.doi.org/10.1055/s-0042-1759744.

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AbstractHistoplasmosis is an uncommon cause of pyrexia of unknown origin in India. We present a case of hepatic histoplasmosis presenting as pyrexia of unknown origin. The patient had splenomegaly, thrombocytopenia, high serum-ascites albumin gradient, and imaging suggestive of cirrhosis. The patient had received 2 months of antitubercular treatment and came to us because of a lack of improvement. A liver biopsy was done because of cholestatic liver function tests and normal biliary system on imaging, thus raising the possibility of infiltrative liver disease. A transjugular liver biopsy revea

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Ugwu, D. I., B. E. Ezema, F. U. Eze, and D. I. Ugwuja. "Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides." International Journal of Medicinal Chemistry 2014 (December 30, 2014): 1–18. http://dx.doi.org/10.1155/2014/614808.

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The unusual structure and chemical composition of the mycobacterial cell wall, the tedious duration of therapy, and resistance developed by the microorganism have made the recurrence of the disease multidrug resistance and extensive or extreme drug resistance. The prevalence of tuberculosis in synergy with HIV/AIDS epidemic augments the risk of developing the disease by 100-fold. The need to synthesize new drugs that will shorten the total duration of effective treatment and/or significantly reduce the dosage taken under DOTS supervision, improve on the treatment of multidrug-resistant tubercu

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Saxena, Anil K., and Muneer Alam. "ATP Synthase Inhibitors as Anti-tubercular Agents: QSAR Studies in Novel Substituted Quinolines." Current Topics in Medicinal Chemistry 20, no. 29 (2020): 2723–34. http://dx.doi.org/10.2174/1568026620666200903163515.

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Background: Tuberculosis (TB) is a major infectious disease caused by Mycobacterium Tuberculosis. As per the World Health Organization (WHO) report of 2019, there were 1.5 million deaths in the year 2018, mainly because of multi- and extensively drug-resistant tuberculosis (MDR & XDR-TB). Among several antitubercular drugs in clinical trials, bedaquiline (TMC207) is a highly promising drug that was approved by the FDA in 2012 and marketed in 2016 for the treatment of multidrug resistant TB in combination with other drugs. Bedaquiline acts on mycobacterial ATP synthase and is highly effecti

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Ghodke, Aashish, Sumedha Singh, Alok Gadkari, Dheeraj Batheja, and Ram Chaddha. "Isolated costotransverse joint tuberculosis - A rare location for tubercular arthritis." Surgical Neurology International 13 (June 23, 2022): 266. http://dx.doi.org/10.25259/sni_398_2022.

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Background: Posterior element involvement of the spine with tuberculosis (TB) is very uncommon. Case Description: A 25-year-old immunocompetent female presented with dull mid-back ache and tenderness over the inferior angle of the left scapula and left 7th costovertebral junction. The MRI showed erosion and enhancing soft tissue in the periarticular region of the left 7th costotransverse joint. After the CT-guided biopsy confirmed the diagnosis of TB, she was successfully managed with antitubercular chemotherapy. Conclusion: In a 25-year-old female, the early diagnosis of atypical TB involving

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Farr, Dylan C., Lendl Tan, Juanelle Furness, I. Darren Grice, Nicholas P. West, and Todd A. Houston. "Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin." Australian Journal of Chemistry 76, no. 11 (2023): 812–20. http://dx.doi.org/10.1071/ch23154.

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Aminoglycoside antibiotics represent the first class of successful drugs in the treatment of tuberculosis; however, mycobacteria and other bacterial species possess several drug resistance mechanisms to inactivate these natural products. In the past 15 years, a variety of amphiphilic aminoglycosides have been shown to have improved activity against infectious microorganisms and to subvert resistance mechanisms. Here, we report on four novel synthetic compounds derived from two existing potent antitubercular compounds and describe their activity against both Mycobacterium tuberculosis and Staph

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Dr., Sonali Banpure* Bhalekar Pournima Ingale Pramod Matade Siddhesh Mhase Pratiksha. "Design, In Silico Evaluation, Synthesis and Biological Evaluation Of 4-Nitroimidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1621–27. https://doi.org/10.5281/zenodo.15381646.

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This study aimed to design and evaluate novel antitubercular agents using computational methods. Four derivatives of isoniazid and acyclovir were designed and subjected to molecular docking studies against the 3IX2 protein. The results showed that the first derivative had the lowest binding energy (-11.58) and formed three hydrogen bonds with the protein. ADMET analysis was performed to evaluate the pharmacokinetic properties of the designed compounds. Based on the molecular docking and ADMET analysis, the first derivative was identified as the most promising compound for further development a

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Kumar, Uma, and Sauvik Dasgupta. "Musculoskeletal Tuberculosis: A Multifaceted Foe." Annals of the National Academy of Medical Sciences (India) 55, no. 01 (2019): 003–5. http://dx.doi.org/10.1055/s-0039-1694070.

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AbstractTuberculosis (TB) still remains a global epidemic, and India accounts for one-fourth of the world's TB burden. The incidence of extrapulmonary TB has relatively remained constant, but with the introduction of antitumor necrosis factor, there has been a surge in pulmonary and extrapulmonary TB cases presenting to rheumatologists. Musculoskeletal TB accounts for 10 to 30% of all cases of extrapulmonary TB, with spondylitis (Pott's spine) being the most common manifestation. Manifestations mimicking autoimmune spondylitis are seen in 10% of cases. Tubercular arthritis most commonly presen

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Unnikrishnan, Ranjith, Ankith Chacko, Muhammad Jasim, Nitheesh Chandran, and S. Gowrishankar. "Multifocal Skeletal Tuberculosis – A Case Report." Journal of Orthopaedic Case Reports 14, no. 7 (2024): 77–82. http://dx.doi.org/10.13107/jocr.2024.v14.i07.4582.

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Introduction: Tuberculosis (TB) remains a pervasive infectious disease, and extrapulmonary manifestations account for a significant proportion of cases. Skeletal involvement is observed in about 10% of extrapulmonary TB instances. While spinal TB is relatively common, sacroiliac (SI) joint TB is a rare occurrence, particularly in immunocompetent individuals. Case Report: This case report discusses an unusual presentation in a 19-year-old immunocompetent lady where the spine, acetabulum, and SI joint were concurrently affected. The patient, initially undergoing alternative medicine, exhibited s

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Anjum, Rashid, Vivek Sharma, and Navdeep Singh. "Isolated tuberculosis of the patella mimicking as prepatellar bursitis." BMJ Case Reports 17, no. 8 (2024): e261535. http://dx.doi.org/10.1136/bcr-2024-261535.

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Patellar tuberculosis (TB) is a rare manifestation of musculoskeletal tuberculosis, accounting for a small proportion of cases. This case report presents a detailed analysis of a female patient in her early 30s who presented with isolated TB of the patella without concurrent pulmonary involvement. The patient received antitubercular chemotherapy, consisting of a 4-month intensive phase followed by an 8-month continuation phase. This case report underscores the rarity and diagnostic complexities associated with patellar TB. The condition often presents with non-specific symptoms, often mimickin

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Chandran, Aswin, Prem Sagar, Rabia Monga, and Shuchita Singh. "Unusual manifestation of Koch’s disease: Gradenigo-Lannois syndrome." BMJ Case Reports 13, no. 11 (2020): e236779. http://dx.doi.org/10.1136/bcr-2020-236779.

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Gradenigo-Lannois syndrome or petrous apicitis is an uncommon but a morbid complication of otitis media. Traditionally treated by surgery, recent advances in imaging and antibiotics have favoured a more conservative approach. Although pyogenic organisms are the leading aetiological agent, petrous apicitis due to Koch’s bacilli is not rare. We report two cases of tubercular petrositis presenting as Gradenigo’s syndrome with triad of ear discharge, deep-seated retro-orbital pain and diplopia. The first patient represented a mixed infection with pyogenic organism and tuberculosis, which was succe

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Soukaina.Laaouina, Soukaina Azib, Adil Elkhouyaali, Aissam.Fiqhi, and Yassine.Mouzari. "Ocular Tuberculosis with Sea Fan Neovascularization: A Case Report and Literature Review." International Journal of Medical and Pharmaceutical Case Reports 18, no. 2 (2025): 20–26. https://doi.org/10.9734/ijmpcr/2025/v18i2417.

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Eye diseases may lead to visual impairment which is one of the public's most feared disabilities. Tuberculosis is a systemic infectious disease caused by Mycobacterium tuberculosis. Ocular tuberculosis is a rare manifestation of this condition. We report the case of a 36-year-old patient who was referred to the ophthalmology department due to acute vision loss in both eyes. An ophthalmological examination revealed retinal vasculitis in both eyes, complicated by pre-retinal neovascularization. Blood tests were positive for QuantiFERON-TB Gold, and the Mantoux test was also positive. Antitubercu

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Banga, Manpreet, Kaushik Roy, Sandeep V., and Sibaji Dasgupta. "Sellar and Suprasellar Tuberculoma." Indian Journal of Neurosurgery 07, no. 01 (2017): 039–42. http://dx.doi.org/10.1055/s-0037-1599787.

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AbstractTuberculosis is responsible for 20% of the intracranial space-occupying lesions in India, and tuberculomas of the sellar and suprasellar region comprise only 1% of all intracranial tuberculomas. The clinical and radiological features of these lesions mimic a typical pituitary adenoma. Surgery is not usually indicated, except for obtaining biopsies to confirm diagnosis, as these lesions tend to resolve with appropriate antitubercular therapy. There is no consensus regarding the type of antitubercular regimen and duration of the treatment as the experience with tuberculomas of pituitary

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