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Journal articles on the topic 'Antitumor activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Shtemenko, N. I., D. E. Kytova, O. V. Berzenina, O. I. Hrabovska, and A. V. Shtemenko. "New formulation and activity of rhenium-platinum antitumor system." Ukrainian Biochemical Journal 94, no. 3 (2022): 92–98. http://dx.doi.org/10.15407/ubj94.03.092.

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Two-component Rhenium-Platinum system (Re-Pt system) is based on administration of a cluster dirhenium(III) compound and cisplatin to tumor bearing animals followed by a significant antitumor effect and decreased toxic effect of cisplatin on normal cells. The aim of this work was to obtain solid lipid nanoparticles (SLN) from surface lipids (waxes) of Chelidonium majus L. (Papaveraceae) leaves and to estimate whether capsulation of dirhenium(III) as a component of the Re-Pt system into SLN will affect its antitumor activity and red blood cells (RBC) morphology in a rat model of Guerin’s carcin

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2

Ferrarelli, L. K. "Engineering antitumor activity." Science 353, no. 6307 (2016): i—1510. http://dx.doi.org/10.1126/science.353.6307.1509-i.

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3

NISHIKAWA, KIYOHIRO, CHIEKO SHIBASAKI, KATSUTOSHI TAKAHASHI, TERUYA NAKAMURA, TOMIO TAKEUCHI, and HAMAO UMEZAWA. "Antitumor activity of spergualin, a novel antitumor antibiotic." Journal of Antibiotics 39, no. 10 (1986): 1461–66. http://dx.doi.org/10.7164/antibiotics.39.1461.

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4

Kasakura, Shinpei. "Cytokines with antitumor activity." Japanese Journal of Clinical Immunology 10, no. 1 (1987): 1–9. http://dx.doi.org/10.2177/jsci.10.1.

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5

Zverev, Y. F. "Antitumor activity of flavonoids." Bulletin of Siberian Medicine 18, no. 2 (2019): 181–94. http://dx.doi.org/10.20538/1682-0363-2019-2-181-194.

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This review of the literature is devoted to the consideration of mechanisms of the antitumor effect of flavonoids. The anticanceromatous effect of flavonoids is discussed in the context of their impact on the main stages of development of malignant tumor cells. At the same time, the influence of flavonoids on the activity of protein kinases, metalloproteinases, apoptosis, angiogenesis and the cell cycle of tumor cells is considered in detail.

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6

MORIMOTO, MAKOTO, and RYOJI IMAI. "ANTITUMOR ACTIVITY OF ECHINOSPORIN." Journal of Antibiotics 38, no. 4 (1985): 490–95. http://dx.doi.org/10.7164/antibiotics.38.490.

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7

ISODA, Yoshihiro, Yukio NISHIZAWA, Shigehiko YAMAGUCHI, Jiro HIRANO, Akihiko YAMAMOTO, and Mitsuhiro NUMATA. "Antitumor Activity of Lipids." Journal of Japan Oil Chemists' Society 42, no. 11 (1993): 923–28. http://dx.doi.org/10.5650/jos1956.42.923.

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8

SAGASTER, P., E. M. KOKOSCHKA, O. KOKRON, and M. MICKSCHE. "Antitumor Activity of Imexon." JNCI Journal of the National Cancer Institute 87, no. 12 (1995): 935–36. http://dx.doi.org/10.1093/jnci/87.12.935-a.

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9

Ryu, Shi Yong, Sang Un Choi, Chong Ock Lee, and Ok Pyo Zee. "Antitumor activity ofPsoralea corylifolia." Archives of Pharmacal Research 15, no. 4 (1992): 356–59. http://dx.doi.org/10.1007/bf02974112.

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10

Ryu, Shi Yong, Seung Ho Lee, Sang Un Choi, Chong Ock Lee, Zaesung No, and Jong Woong Ahn. "Antitumor activity ofTrichosanthes kirilowii." Archives of Pharmacal Research 17, no. 5 (1994): 348–53. http://dx.doi.org/10.1007/bf02974175.

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11

Teplán, I. "Peptides and antitumor activity." Acta Biologica Hungarica 51, no. 1 (2000): 1–29. http://dx.doi.org/10.1007/bf03542961.

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12

Sasaki, Shoji, Kenjiro Kodama, Kazuo Uchida, and Hiroshi Yoshino. "Antitumor Activity ofAspergillusCell Walls." Agricultural and Biological Chemistry 49, no. 4 (1985): 1219–21. http://dx.doi.org/10.1080/00021369.1985.10866882.

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13

ISHII, SHIGETAKA, MIEKO NAGASAWA, YUKO KARIYA, et al. "Antitumor activity of ankinomycin." Journal of Antibiotics 42, no. 10 (1989): 1518–19. http://dx.doi.org/10.7164/antibiotics.42.1518.

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14

KUMAGAI, HIROYUKI, TORU MASUDA, MASAAKI ISHIZUKA, and TOMIO TAKEUCHI. "Antitumor Activity of Cytogenin." Journal of Antibiotics 48, no. 2 (1995): 175–78. http://dx.doi.org/10.7164/antibiotics.48.175.

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15

Eckardt, John R. "Antitumor activity of docetaxel." American Journal of Health-System Pharmacy 54, suppl_2 (1997): S2—S6. http://dx.doi.org/10.1093/ajhp/54.suppl_2.s2.

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16

Ostrovskaya, L. A., D. B. Korman, S. D. Varfolomeev, et al. "Polysuccinimide: Experimental antitumor activity." Biophysics 60, no. 2 (2015): 298–302. http://dx.doi.org/10.1134/s000635091502013x.

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17

IKEKAWA, Tetsuro, Hideharu SAITOH, Weijian FENG, Huiling ZHANG, Langfang LI, and Tsunetomo MATSUZAWA. "Antitumor Activity of Hypsizigus marmoreus. I. Antitumor Activity of Extracts and Polysaccharides." CHEMICAL & PHARMACEUTICAL BULLETIN 40, no. 7 (1992): 1954–57. http://dx.doi.org/10.1248/cpb.40.1954.

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18

Cibotaru, Sandu, Andreea-Isabela Sandu, Alina Nicolescu, and Luminita Marin. "Antitumor Activity of PEGylated and TEGylated Phenothiazine Derivatives: Structure–Activity Relationship." International Journal of Molecular Sciences 24, no. 6 (2023): 5449. http://dx.doi.org/10.3390/ijms24065449.

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The paper aims to investigate the antitumor activity of a series of phenothiazine derivatives in order to establish a structure–antitumor activity relationship. To this end, PEGylated and TEGylated phenothiazine have been functionalized with formyl units and further with sulfonamide units via dynamic imine bonds. Their antitumor activity was monitored in vitro against seven human tumors cell lines and a mouse one compared to a human normal cell line by MTS assay. In order to find the potential influence of different building blocks on antitumor activity, the antioxidant activity, the ability t

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19

Gomi, Katsushige, Eiji Kobayashi, Katsunori Miyoshi, et al. "Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics." Japanese Journal of Cancer Research 83, no. 1 (1992): 113–20. http://dx.doi.org/10.1111/j.1349-7006.1992.tb02360.x.

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20

P., J. Jainey, and Ishwar Bhat K. "Synthesis, antitumor and antioxidant activity studies of cyanopyridones." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 945–50. https://doi.org/10.5281/zenodo.5674233.

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Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India <em>E-mail</em> : jaineyjames@gmail.com Cyanopyridone derivatives are generated by both microwave assisted and conventional methods. The condensation of chalcones with ethylcyanoacetate in the presence of ammonium acetate in ethanol leads to cyanopyridones. In microwave synthesis, the reactions are considerably faster and the yields are significantly higher compared to conventionally heated reactions. All compounds were tested for antitum

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21

Villa-Pulgarin, Janny A., Constain H. Salamanca, Jose Oñate-Garzón, and Ruben E. Varela-M. "Antitumor Activity In Vitro Provided by N-Alkyl-Nitroimidazole Compounds." Open Medicinal Chemistry Journal 14, no. 1 (2020): 45–48. http://dx.doi.org/10.2174/1874104502014010045.

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Background: Cancer is one of the most common diseases in the world, with over 18 million new cases estimated in 2018. Many of the drugs used for cancer can have significant adverse effects and variable effectiveness. Nitroimidazoles are prodrugs that usually have shown antimicrobial activity specifically antiparasitic. However, its antitumor activity in vitro has barely been explored. Objective: The aim of this study is to determine the influence of the length of the substituted N-alkyl chain in the imidazole ring on the antitumor activity in vitro. Methods: Four nitroimidazoles were obtained

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22

Rodrigues, de Oliveira Rodrigo, Souza Sales Queitilane de, Braga Gonçalves Fernanda Manhães, et al. "Phytochemical analysis and cytotoxic activity of Petiveria alliacea (Phytolaccaceae)." International Journal of Sciences Volume 5, no. 2016-04 (2016): 52–58. https://doi.org/10.5281/zenodo.3349175.

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Petiveria alliacea (Phytolaccaceae) is a small shrub which grows in Africa and tropical America, where it is popularly known as "tipim", "tipi" and "guiné". The leaves are used in folk medicine as diuretic, sedative or analgesic. Phytochemical investigation led to the identification of eight compounds, six of which are being described for the first time in this species: stigmasterol, stigmastenol, stigmastanol, loliolide, 3-hydroxy-5,6-epoxy-β-ionone and benzyl-β-glucopyranoside. The hexane and dichloromethane fractions presented good antitumor activity besides low toxicity. The compounds isol

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23

KOMIYAMA, KANKI, KENJI OKADA, SHIGERU TOMISAKA, IWAO UMEZAWA, TETSUO HAMAMOTO, and TERUHIKO BEPPU. "Antitumor activity of leptomycin B." Journal of Antibiotics 38, no. 3 (1985): 427–29. http://dx.doi.org/10.7164/antibiotics.38.427.

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24

Gao, Huimin, Ruxandra Popescu, Brigitte Kopp, and Zhimin Wang. "Bufadienolides and their antitumor activity." Natural Product Reports 28, no. 5 (2011): 953. http://dx.doi.org/10.1039/c0np00032a.

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25

La Ferla, Barbara, Cristina Airoldi, Cristiano Zona, et al. "Natural glycoconjugates with antitumor activity." Nat. Prod. Rep. 28, no. 3 (2011): 630–48. http://dx.doi.org/10.1039/c0np00055h.

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26

Lou, Yanyan, Chengwen Liu, Gregory Lizée, et al. "Antitumor Activity Mediated by CpG." Journal of Immunotherapy 34, no. 3 (2011): 279–88. http://dx.doi.org/10.1097/cji.0b013e31820d2a05.

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27

Foley, John F. "Unsilencing antitumor T cell activity." Science Signaling 8, no. 407 (2015): ec370-ec370. http://dx.doi.org/10.1126/scisignal.aaf0596.

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28

Takayasu, J., Y. Yamaoka, Y. Nakagawa, H. Nishino, and A. Iwashima. "Antitumor-Promoting Activity of Eperisone." Oncology 46, no. 1 (1989): 58–60. http://dx.doi.org/10.1159/000226682.

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29

Matoušek, Josef. "Ribonucleases and their antitumor activity." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 129, no. 3 (2001): 175–91. http://dx.doi.org/10.1016/s1532-0456(01)90202-9.

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30

Foss, Francine M. "Immunologic mechanisms of antitumor activity." Seminars in Oncology 29, no. 3 (2002): 5–11. http://dx.doi.org/10.1053/sonc.2002.33076.

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31

Norman, Amos, Leslie R. Bennett, James F. Mead, and Keisuke S. Iwamoto. "Antitumor activity of sodium Linoleate." Nutrition and Cancer 11, no. 2 (1988): 107–15. http://dx.doi.org/10.1080/01635588809513977.

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32

Butin, B. M., S. A. Baisakbaeva, B. K. Beketova, B. N. Mynbaeva, and E. T. Nikitina. "Antitumor activity of selenabicyclodecanone derivatives." Pharmaceutical Chemistry Journal 29, no. 8 (1995): 526–27. http://dx.doi.org/10.1007/bf02219005.

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33

Edwards, Michael L., N. J. Prakash, D. M. Stemerick, et al. "Polyamine analogs with antitumor activity." Journal of Medicinal Chemistry 33, no. 5 (1990): 1369–75. http://dx.doi.org/10.1021/jm00167a014.

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34

Aujla, Mandy. "PARP inhibitor has antitumor activity." Nature Reviews Clinical Oncology 6, no. 9 (2009): 496. http://dx.doi.org/10.1038/nrclinonc.2009.118.

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35

Yang, Q., S. R. Goding, M. E. Hokland, and P. H. Basse. "Antitumor Activity of NK Cells." Immunologic Research 36, no. 1-3 (2006): 13–26. http://dx.doi.org/10.1385/ir:36:1:13.

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36

Kunick, C. "Fused Azepinones with Antitumor Activity." Current Pharmaceutical Design 5, no. 3 (1999): 181–94. http://dx.doi.org/10.2174/1381612805666230109214720.

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Based on the observation that some simple [l]benzazepin-2-ones exhibit in vivo antitumor activity, studies directed to several new structure classes with this partial motif have been reported recently, comprising 7,l 2-dihydro-indolo[3,2-d][l ]benzazepin- 6(5H)-ones (paullones), 5H-quinolino[3,2-d][ I ]benzazepin-6(7H)-ones, 2,4-diaryl-5H• pyrido[3,2-d][ I ]benzazepin-6(7H)-ones, spiro[ l-benzazepine-4, l '-cyclohexane] deri va tives, and naphthannelated benzazepinones. For the syntheses of these heterocyclic compounds, IH-[l]benzazepine-2,5(3H,4H)-diones were employed as readily available ;

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37

Kim, Seon-Hee, Gyu-Yong Song, Guang-Zhu Jin, and Byung-Zun Ahn. "Antitumor activity of arylacetylshikonin analogues." Archives of Pharmacal Research 19, no. 5 (1996): 416–22. http://dx.doi.org/10.1007/bf02976389.

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38

Zhubanov, B. A., G. I. Boiko, K. A. Abdulin, M. B. Umerzakova, and Zh K. Ibraeva. "Tricyclodecenetetracarboxydiimides and their antitumor activity." Pharmaceutical Chemistry Journal 25, no. 1 (1991): 38–40. http://dx.doi.org/10.1007/bf00766364.

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39

Brunda, Michael J., and Maurice K. Gately. "Antitumor Activity of Interleukin-12." Clinical Immunology and Immunopathology 71, no. 3 (1994): 253–55. http://dx.doi.org/10.1006/clin.1994.1081.

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40

Noda, Hiroyuki, Hideomi Amano, Koichi Arashima, and Kazutosi Nisizawa. "Antitumor activity of marine algae." Hydrobiologia 204-205, no. 1 (1990): 577–84. http://dx.doi.org/10.1007/bf00040290.

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41

Kulikova, Vitalia V., Elena A. Morozova, Vasiliy S. Koval, Pavel N. Solyev, Tatyana V. Demidkina, and Svetlana V. Revtovich. "Thiosulfinates: Cytotoxic and Antitumor Activity." Biochemistry (Moscow) 88, no. 7 (2023): 912–23. http://dx.doi.org/10.1134/s0006297923070052.

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42

Kulikova, V. V., E. A. Morozova, V. S. Koval, P. N. Solyev, T. V. Demidkina, and S. V. Revtovich. "Thiosulfinates: cytotoxic and antitumor activity." Биохимия 88, no. 7 (2023): 1123–36. http://dx.doi.org/10.31857/s0320972523070059.

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The pharmacological value of some natural compounds makes them attractive for use in oncology. Sulfur-containing thiosulfinates found in plants of the genus Allium have long been known as compounds with various therapeutic properties, including antitumor. In recent years, the effect of thiosulfinates on various stages of carcinogenesis has been actively studied. In vitro and in vivo studies have shown that thiosulfinates inhibit the proliferation of cancer cells, as well as induce apoptosis. The purpose of this review is to summarize current data on the use of natural and synthetic thiosulfina

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43

ISHIZEKI, SEIJI, MARI OHTSUKA, KAZUHIKO IRINODA, KEN-ICHI KUKITA, KATSUHIKO NAGAOKA, and TOSHIAKI NAKASHIMA. "Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity." Journal of Antibiotics 40, no. 1 (1987): 60–65. http://dx.doi.org/10.7164/antibiotics.40.60.

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44

ZHEN, YONG-SU, XIU-YING MING, BIN YU, TOSHIO OTANI, HITOSHI SAITO, and YUJI YAMADA. "A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity." Journal of Antibiotics 42, no. 8 (1989): 1294–98. http://dx.doi.org/10.7164/antibiotics.42.1294.

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45

Akima, Kazuo, Hisashi Ito, Yuhei Iwata, et al. "Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity." Journal of Drug Targeting 4, no. 1 (1996): 1–8. http://dx.doi.org/10.3109/10611869609046255.

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46

Yu, Wang, and Li Ling. "Research Progress of Antitumor Activity by Baicalin and Baicalein." International Journal of Sciences Volume 8, no. 2019-06 (2019): 11–14. https://doi.org/10.5281/zenodo.3350775.

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Baicalin and its aglycon, baicalein, are flavonoids present from Scutellaria baicalensis Georgi. Baicalin generally inhibits tumor cells by inducing apoptosis and arresting growth, while baicalein suppresses by regulating autophagy. Certain signaling pathways and regulating factors are involved among the induced-apoptosis and autophagy progress. In suppressing growth, baicalin and baicaein inhibit angiogenesis or induce cell cycle arrest at S phase against proliferation, migration and differentiation. The present agents against tumor still have related side effects. Therefore, the natural and

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47

Javlonabduraimovich, Yuldashev, Ibragimov Shavkat Narzikulovich, Shakhanova Shakhnoza Shavkatovna та Esankulova Bustonoy Sobirovna. "STUDY OF ACUTE TOXICITY AND ANTITUMOR ACTIVITY OF NEW COLCHAMETIN PREPARATION СOLCHAMETIN". International Journal of Medical Sciences And Clinical Research 03, № 03 (2023): 29–36. http://dx.doi.org/10.37547/ijmscr/volume03issue03-05.

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The aim of the study was to study acute toxicity in different methods of administration in mice and rats of a new antitumor preparation "colchametin" (K-2) and its antitumor activity on 2 strains of tumors Material and research methods. Acute toxicity of the preparation K-2 with a single intraperitoneal administration was carried out according to the Litchfield and Wilcoxon method in 60 white infertile mice weighing 202g. both sexes and 60 male and female rats weighing 14010g 5 animals in each group, a total of 120 mice and rats were used. The study of antithumor activity was performed on 12

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48

Pérez, Marina, Berta Buey, Pilar Corral, David Giraldos, and Eva Latorre. "Microbiota-Derived Short-Chain Fatty Acids Boost Antitumoral Natural Killer Cell Activity." Journal of Clinical Medicine 13, no. 13 (2024): 3885. http://dx.doi.org/10.3390/jcm13133885.

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Background: The intestinal microbiota can regulate numerous host functions, including the immune response. Through fermentation, the microbiota produces and releases microbial metabolites such as short-chain fatty acids (SCFAs), which can affect host homeostasis. There is growing evidence that the gut microbiome can have a major impact on cancer. Specific gut microbial composition and metabolites are associated with tumor status in the host. However, their effects on the antitumor response have scarcely been investigated. Natural killer (NK) cells play an important role in antitumor immunity d

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49

Ivanova, Stefka. "Metal-based organic complexes with anticancer activity." Bulgarian Society of Medical Sciences Journal 6 (October 28, 2024): e136135. https://doi.org/10.3897/bsms.6.136135.

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The discovery of the mechanism of action and the main structure-activity dependencies of platinum complexes create opportunities for rational synthesis of new metal-based organic complexes as potential antitumor drugs with reduced resistance and toxicity and / or a wider spectrum of antitumor activity. In the field of targeted synthesis of antitumor complexes has been working hard for 40 years. Initial research focused on obtaining complexes with a structure similar to cisplatin, and later on the search for new "non-classical" antitumor complexes. Selection of a suitable ligand system, ensurin

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50

Wang, Xinmin, Ying Wang, Jialiang Hu, and Hanmei Xu. "An antitumor peptide RS17‐targeted CD47, design, synthesis, and antitumor activity." Cancer Medicine 10, no. 6 (2021): 2125–36. http://dx.doi.org/10.1002/cam4.3768.

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