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Relevant bibliographies by topics / Antitumor Metallodrugs

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Journal articles
Dissertations / Theses
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Academic literature on the topic 'Antitumor Metallodrugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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Journal articles on the topic "Antitumor Metallodrugs"

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Li, Xuezhao, Zhuolin Shi, Jinguo Wu, et al. "Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy." Chemical Communications 56, no. 55 (2020): 7537–48. http://dx.doi.org/10.1039/d0cc02194f.

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DNA distortion induced by metallodrugs is one of the main subjects for drug design. In this Feature Article, the developments of DNA-targeted metallohelices for antitumor chemotherapy and photodynamic therapy are presented with future perspectives.

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Liu, Wukun, and Ronald Gust. "Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs." Chem. Soc. Rev. 42, no. 2 (2013): 755–73. http://dx.doi.org/10.1039/c2cs35314h.

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Liu, Wukun, and Ronald Gust. "ChemInform Abstract: Metal N-Heterocyclic Carbene Complexes as Potential Antitumor Metallodrugs." ChemInform 44, no. 20 (2013): no. http://dx.doi.org/10.1002/chin.201320229.

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Morais, Tânia S., Andreia Valente, Ana Isabel Tomaz, Fernanda Marques, and Maria Helena Garcia. "Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds." Future Medicinal Chemistry 8, no. 5 (2016): 527–44. http://dx.doi.org/10.4155/fmc.16.7.

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Timerbaev, Andrei R., Christian G. Hartinger, Svetlana S. Aleksenko, and Bernhard K. Keppler. "Interactions of Antitumor Metallodrugs with Serum Proteins: Advances in Characterization Using Modern Analytical Methodology." Chemical Reviews 106, no. 6 (2006): 2224–48. http://dx.doi.org/10.1021/cr040704h.

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Abás, Elisa, Diego Aguirre-Ramírez, Mariano Laguna, and Laura Grasa. "Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes." Biomedicines 9, no. 12 (2021): 1775. http://dx.doi.org/10.3390/biomedicines9121775.

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New dithiocarbamate cycloaurated complexes have been synthesized and their physicochemical and in vitro antitumor properties have been evaluated. All the performed studies highlighted good transport through the blood and biodistribution, according to the balance between the properties of hydrophilicity/lipophilicity and the binding of moderate strength to the BSA protein. Furthermore, none of the complexes exhibited reduction or decomposition reactions, presenting excellent physiological stability. The in vitro cytotoxic effect was evaluated on human colon cancer cell line Caco-2/TC7, and the

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Erxleben, Andrea. "Mitochondria-Targeting Anticancer Metal Complexes." Current Medicinal Chemistry 26, no. 4 (2019): 694–728. http://dx.doi.org/10.2174/0929867325666180307112029.

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Background: Since the serendipitous discovery of the antitumor activity of cisplatin there has been a continuous surge in studies aimed at the development of new cytotoxic metal complexes. While the majority of these complexes have been designed to interact with nuclear DNA, other targets for anticancer metallodrugs attract increasing interest. In cancer cells the mitochondrial metabolism is deregulated. Impaired apoptosis, insensitivity to antigrowth signals and unlimited proliferation have been linked to mitochondrial dysfunction. It is therefore not surprising that mitochondria have emerged

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Tolbatov, Iogann, Alessandro Marrone, Cecilia Coletti, and Nazzareno Re. "Computational Studies of Au(I) and Au(III) Anticancer MetalLodrugs: A Survey." Molecules 26, no. 24 (2021): 7600. http://dx.doi.org/10.3390/molecules26247600.

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Owing to the growing hardware capabilities and the enhancing efficacy of computational methodologies, computational chemistry approaches have constantly become more important in the development of novel anticancer metallodrugs. Besides traditional Pt-based drugs, inorganic and organometallic complexes of other transition metals are showing increasing potential in the treatment of cancer. Among them, Au(I)- and Au(III)-based compounds are promising candidates due to the strong affinity of Au(I) cations to cysteine and selenocysteine side chains of the protein residues and to Au(III) complexes b

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Drius, Giacomo, Silvia Bordoni, Carla Boga, et al. "Synthesis and Antiproliferative Insights of Lipophilic Ru(II)-Hydroxy Stearic Acid Hybrid Species." Molecules 28, no. 10 (2023): 4051. http://dx.doi.org/10.3390/molecules28104051.

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Metallodrugs represent a combination of multifunctionalities that are present concomitantly and can act differently on diverse biotargets. Their efficacy is often related to the lipophilic features exhibited both by long carbo-chains and the phosphine ligands. Three Ru(II) complexes containing hydroxy stearic acids (HSAs) were successfully synthesized in order to evaluate possible synergistic effects between the known antitumor activity of HSA bio-ligands and the metal center. HSAs were reacted with [Ru(H)2CO(PPh3)3] selectively affording O,O-carboxy bidentate complexes. The organometallic spe

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Petanidis, Savvas, Efrosini Kioseoglou, and Athanasios Salifoglou. "Metallodrugs in Targeted Cancer Therapeutics: Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks." Current Medicinal Chemistry 26, no. 4 (2019): 607–23. http://dx.doi.org/10.2174/0929867324666171116125908.

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Tumor cell chemoresistance is a major challenge in cancer therapeutics. Major select metal-based drugs are potent anticancer mediators yet they exhibit adverse sideeffects and are efficient against limited types of malignancies. A need, therefore, arises for novel metallodrugs with improved efficacy and decreased toxicity. Enhancement of antitumor drugs based on anticancer metals is currently a very active research field, with considerable efforts having been made toward elucidating the mechanisms of immune action of complex metalloforms and optimizing their immunoregulatory bioactivity throug

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Dissertations / Theses on the topic "Antitumor Metallodrugs"

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Sanghamitra, Nusrat Jahan Mobassarah. "Synthesis, Characterization And Anticancer Activity Of Copper(I) Phosphine Complexes." Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1516.

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Das, Sangeeta. "Ancillary Ligand Effects On The Anticancer Activity Of Ruthenium(II) Piano Stool Complexes." Thesis, 2009. http://hdl.handle.net/2005/998.

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The thesis “Ancillary Ligand Effects on the Anticancer Activity of Ruthenium (II) Piano Stool Complexes” is an effort to design better antitumor metallodrugs based on ruthenium(II) complexes with various H-bond donor/acceptor ligands and to understand their mechanism of action. Chapter 1 presents a brief review of metallodrugs and their mechanism of action. Different classes of metallodrugs are discussed. A short discussion on ruthenium based anticancer drugs and their established mechanism of action is also included in this chapter. Chapter 2 deals with the synthesis, characterization and a

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Book chapters on the topic "Antitumor Metallodrugs"

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Sullivan, Matthew P., Hannah U. Holtkamp, and Christian G. Hartinger. "13. Antitumor Metallodrugs that Target Proteins." In Metallo-Drugs: Development and Action of Anticancer Agents, edited by Astrid Sigel, Helmut Sigel, Eva Freisinger, and Roland K. O. Sigel. De Gruyter, 2018. http://dx.doi.org/10.1515/9783110470734-019.

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Tolbatov, Iogann, and Alessandro Marrone. "Structural Basis of the Biomolecular Action of Paddlewheel- and N-Heterocyclic-Carbene-Based Antitumor Metallodrugs: A Computational Perspective." In Computational Science and Its Applications – ICCSA 2022 Workshops. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-10592-0_22.

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"13. ANTITUMOR METALLODRUGS THAT TARGET PROTEINS." In Metallo-Drugs: Development and Action of Anticancer Agents. De Gruyter, 2018. http://dx.doi.org/10.1515/9783110470734-013.

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Conference papers on the topic "Antitumor Metallodrugs"

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Hussaini, Sunusi Y., Rosenani A. Haque, Mohd R. Razali, and A. M. S. Abdul Majid. "Effects of supramolecular interactions in nitrile functionalized silver(I)-N-heterocyclic carbene complexes and investigation into their enhancement of antitumor metallodrugs." In 4TH INTERNATIONAL CONFERENCE ON THE SCIENCE AND ENGINEERING OF MATERIALS: ICoSEM2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0027461.

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