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Journal articles on the topic 'Antitussive drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

KOLOSOVA, N. G., and S. I. SHATALINA. "ANTITUSSIVE DRUGS IN CHILDREN’S PRACTICE." Medical Council, no. 9 (July 18, 2017): 76–79. http://dx.doi.org/10.21518/2079-701x-2017-9-76-79.

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Adequate choice and use of antitussive therapy in pediatrics presupposes knowing at least the two key aspects: causes of cough and the specific mechanism of the cough reflex in children, as well as the mechanisms of action of antitussive drugs used. The need for the treatment of cough as such, that is, prescription of the so-called antitussive drugs, arises mainly in children with nonproductive, dry, persistent cough. Central antitussives suppress the function of the cough center in the medulla oblongata or other associated nerve centers of the brain. The antitussive drug butamirate, often use

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2

Prasanna K, Thomas, Jog Pramod, Vohra Nitin R, Veligandla Krishna C, and Petare Uttam Anup. "A Newer Approach in the Management of Cough: A Review on Levodropropizine." Journal of Respiratory Diseases 1, no. 3 (2023): 1–14. http://dx.doi.org/10.14302/issn.2642-9241.jrd-23-4566.

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Safe and effective antitussive therapy remains a significant area of unmet need for cough management. Antitussive drugs are commonly used cough suppressants and include centrally acting (opioids and non-opioids) cough suppressants and peripherally acting antitussives. Authors searched PubMed, Google Scholar and additional studies from reference lists via cross-referencing to identify studies assessing levodropropizine for the treatment of cough. Of the 748 studies identified, 13 were included. Recent clinical evidence, guideline recommendations and findings from this review suggest that levodr

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3

Sohn, Jang Won. "Antitussive and mucoactive drugs." Journal of the Korean Medical Association 56, no. 11 (2013): 1025. http://dx.doi.org/10.5124/jkma.2013.56.11.1025.

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4

Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "Understanding the Mechanism of Action of Antitussive Drugs." Journal of Advances in Experimental Therapeutics and Neurotherapeutics 2, no. 1 (2024): 17–20. https://doi.org/10.5281/zenodo.10795828.

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<em>Coughing is a natural reflex that assists in clearing the airways of irritants and mucus. Opioid have been used as an effective antitussive compounds namely codeine and hydro condone are helpful in stopping coughing in a wide manner. By binding with mu Opioid receptors, opioid ms stop the release of neurotransmitters particularly participated I'm the cough reflex and decrease the urge to cough. Dextro methorphin ( DXM) is a non_ Opioid derivative that participates in the over the counter cough medications. If performs centrally by blocking N_ methyl_D_ asparate (NMDA) receptors and stoppin

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Dicpinigaitis, P. V., A. H. Morice, S. S. Birring, et al. "Antitussive Drugs—Past, Present, and Future." Pharmacological Reviews 66, no. 2 (2014): 468–512. http://dx.doi.org/10.1124/pr.111.005116.

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6

Robab, Sana, and Nida Saleem. "Search for the Natural Remedies for the Treatment of Dry Cough." Phytopharmacological Communications 3, no. 2 (2023): 125–43. http://dx.doi.org/10.55627/ppc.003.02.0386.

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Cough, also known as tussis, is a normal physiological response to any intrusion in the airway. However, this protective mechanism can turn into a nuisance if it becomes persistent, significantly impacting the social, physical, and psychological performance of a person. Standard antitussive agents like dextromethorphan (DXM), codeine, and gabapentin produce various side effects, and in some cases, cough relapse occurs as soon as drug doses are reduced. In search of better alternatives, this article delves into plant-based antitussive agents, studied in-vivo in various cough models. The cough m

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7

Kholodova, I. N. "Features of cough therapy in children." Meditsinskiy sovet = Medical Council, no. 17 (November 1, 2021): 102–9. http://dx.doi.org/10.21518/2079-701x-2021-17-102-109.

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This article discusses the problem of cough in children as one of the symptoms of a complicated course of acute respiratory infection. The data on the peculiarities of the course of cough in children depending on the cause, the level of damage, and age are presented. Virulence of infectious agents, immune status, and the child’s constitution may influence the development of local inflammation covering the tonsils, adenoids, pharynx, larynx. The study of respiratory problems in children remains relevant due to the need to improve therapy tactics and rehabilitation after an infection. Acute uppe

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8

Mutolo, Donatella, Fulvia Bongianni, Elenia Cinelli, and Tito Pantaleo. "Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit." Journal of Applied Physiology 109, no. 4 (2010): 1002–10. http://dx.doi.org/10.1152/japplphysiol.00406.2010.

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We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern. These findings led us to suggest that the cVRG region, and possibly other neural substrates involved in cough regulation, may be sites of action of antitussive drugs. To address this issue, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation followin

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9

Manjhi, Pramod Kumar, Sunil Kumar Singh, Chakrapani Kumar, and Akhilesh Kumar Rana. "Rational use and cost variation analysis of antitussive-expectorants available in the Indian market: a pharmacoeconomic study." International Journal of Basic & Clinical Pharmacology 10, no. 12 (2021): 1342. http://dx.doi.org/10.18203/2319-2003.ijbcp20214474.

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Background: Antitussive-expectorants are among the most frequently prescribed drugs by physicians in clinical practice. Upper respiratory tract infections, such as common cold, acute pharyngitis and acute trachea-bronchitis, are the most common of all communicable diseases and significantly increase OPD burden. This study aimed to assess the rational use, cost ratio, and percentage cost variations in different brands of the commonly prescribed antitussive-expectorants available in the Indian market.Methods: The cost of antitussive-expectorant manufactured by different pharmaceutical companies

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10

Kiran, Kumari* Akhil Thakur Ajeet Kumar Nikhil Kumar. "Formulation and evaluation of polyherbal antitussive." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 992–97. https://doi.org/10.5281/zenodo.11221410.

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Cough remain as untreated and symptoms of multiple disease. Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastro oesophageal reflux, and as a problem in its own right in patients with chronic cough of unknown origin. Cough remains a major unmet medical need and, although the centrally acting opioids have remained the antitussive drug of choice for decades, such opioids possess many unwanted side-effects. Now a days the synthetic and novel drugs are the major source of curing any type of di

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11

Mackenzie, Auralyn J., Domenico Spina, and Clive P. Page. "Models used in the development of antitussive drugs." Drug Discovery Today: Disease Models 1, no. 3 (2004): 297–302. http://dx.doi.org/10.1016/j.ddmod.2004.10.009.

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12

Скепьян, Е. Н. "Basics of Rational Use and Overview of the Antitussive Medicines Available on the Market." Рецепт, no. 4 (November 11, 2021): 470–79. http://dx.doi.org/10.34883/pi.2021.24.4.005.

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Кашель - одно из наиболее частых клинических проявлений острых инфекционных заболеваний верхних и нижних дыхательных путей. В статье рассмотрены классификация, причины возникновения, подходы к диагностике и лечению кашля. Представлена классификация противокашлевых лекарственных средств. Описаны клинико-фармакологические особенности применения отдельных противокашлевых лекарственных средств и даны рекомендации по их применению в клинической практике. Cough is one of the most common clinical manifestations of acute infectious diseases of the upper and lower respiratory tract. In the article, the

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Skepian, Е. N. "CLINICAL AND PHARMACOLOGICAL FEATURES OF APPLICATION WITH AN OVERVIEW OF THE COUNTRIES ON THE MARKET AN TIT UIS H DRUGS." Medical Journal, no. 3(77) (2021): 140–46. http://dx.doi.org/10.51922/1818-426x.202l3.140.

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Cough is one of the most common clinical manifestations of acute infectious diseases of the upper and lower respiratory tract. Patients complaining of coughing represent one of the most numerous groups in the practice of a doctor. In most cases, an acute cough usually resolves on its own and rarely requires additional medical intervention. Chronic cough can be a manifestation of a variety of pulmonary and extra pulmonary diseases. A long course of chronic cough can lead to both somatic disorders and psychological and social difficulties. Since cough can be caused by many factors, it is often d

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14

Bolser, Donald C., John A. Hey, and Richard W. Chapman. "Influence of central antitussive drugs on the cough motor pattern." Journal of Applied Physiology 86, no. 3 (1999): 1017–24. http://dx.doi.org/10.1152/jappl.1999.86.3.1017.

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The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats. Cough was produced by mechanical stimulation of the intrathoracic trachea. Centrally acting drugs administered included codeine, morphine, dextromethorphan, baclofen, CP-99,994, and SR-48,968. Intravertebral artery administration of all drugs reduced cough number (number of coughs per stimulus trial) and rectus abdominis burst amplitude i

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15

Okovityi, S. V., D. S. Sukhanov, and A. A. Zaicev. "Cough associated with the new coronavirus infection (COVID-19): rational approaches to pharmacotherapy." PULMONOLOGIYA 32, no. 2 (2022): 232–38. http://dx.doi.org/10.18093/0869-0189-2022-32-2-232-238.

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Cough is one of the most frequent symptoms of the new coronavirus infection (COVID-19). It reduces the quality of life and contributes to the development of life-threatening conditions.Aim. This article analyzes modern approaches to the pharmacotherapy of cough in patients with the new coronavirus infection from the standpoint of pathogenetic justification of the use of drugs. The main mechanisms of cough development in COVID-19 presented in the literature are considered. The cough is associated with virus-induced damage to the epithelium and subsequent release of biologically active substance

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16

Altaeva, A., and A. Kozhanova. "THE USE OF ANTITUSSIVE DRUGS FOR COUGH IN CHILDREN." Sciences of Europe, no. 117 (May 23, 2023): 22–24. https://doi.org/10.5281/zenodo.7960980.

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When choosing antitussive medications, you should know the cause of cough, the pathogenesis of the cough reflex in children and the mechanism of action of the medications prescribed by you. The variety of factors leading to the occurrence of cough in childhood, in some cases, creates difficulties in differential diagnosis and treatment [1].

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17

McLeod, Robbie L., Deen B. Tulshian, and John A. Hey. "Novel pharmacological targets and progression of new antitussive drugs." Expert Opinion on Therapeutic Patents 13, no. 10 (2003): 1501–12. http://dx.doi.org/10.1517/13543776.13.10.1501.

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18

Bolser, Donald C. "Mechanisms of Action of Central and Peripheral Antitussive Drugs." Pulmonary Pharmacology 9, no. 5-6 (1996): 357–64. http://dx.doi.org/10.1006/pulp.1996.0047.

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19

Kamei, Junzo, Yuriko Iwamoto, Miwa Misawa та Yutaka Kasuya. "Effects of rimcazole, a specific antagonist of σ sites, on the antitussive effects of non-narcotic antitussive drugs". European Journal of Pharmacology 242, № 2 (1993): 209–11. http://dx.doi.org/10.1016/0014-2999(93)90083-t.

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20

Swapnali, Kapse* Rutuja Kakde Ashwin Pundkar Manjusha Markad Prachi Murkute Dr. Santosh Payghan. "Formulation Evaluation and Comparative Study of Antitussive Tablet with Marketed Formulation." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1788–802. https://doi.org/10.5281/zenodo.15220911.

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In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. The role of traditional medicines in the solution of health problems is invaluable on a global level. India is the largest producer of medicinal herbs and is called as botanical garden of the world. The problem emerging from the treatment of cough during many types of respiratory diseases by conventional opioid antitussive agents, such as codeine and codeine like compou

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21

Liu, Yuan, Shaoneng Xiang, Yanying Wang, and Qinghua Xu. "Effects of drug treatments and types of drugs used by pregnant women at different gestational ages on pregnancy outcomes: A retrospective study." Medicine 104, no. 11 (2025): e41646. https://doi.org/10.1097/md.0000000000041646.

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To analyze the effects of drug treatments and types of drugs on pregnancy outcomes in pregnant women at different gestational ages. The records of 526 pregnant women from our hospital from September 2018 to January 2024 were analyzed retrospectively. Women were categorized into 3 groups: normal delivery, artificial abortion, and spontaneous abortion. Data on maternal age, gestational age, smoking, drinking, radiation, medication timing, and types were collected and compared. Pearson correlation analysis assessed relationships between pregnancy outcomes, gestational age at medication, and medic

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22

KAMEI, Junzo, Tomokazu HOSOKAWA, Saizo YANAURA, and Takehiko HUKUHARA. "Effects of naloxone on the cough depressant activities of antitussive drugs." Folia Pharmacologica Japonica 87, no. 6 (1986): 641–48. http://dx.doi.org/10.1254/fpj.87.641.

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23

Deisemann, Heike, Nadine Ahrens, Irene Schlobohm, Christian Kirchhoff, Rainer Netzer, and Clemens Möller. "Effects of Common Antitussive Drugs on the hERG Potassium Channel Current." Journal of Cardiovascular Pharmacology 52, no. 6 (2008): 494–99. http://dx.doi.org/10.1097/fjc.0b013e31818eec8d.

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24

Mega Salamatul Masruroh, Zeeshan Ali, and Viola Dwicha Asda Asda. "BIOINFORMATION STUDY OF NONI (MORINDA CITRIFOLIA) AS ANTITUSSIVE AGENT AGAINST SARS-COV-2." PROBILITAS 1, no. 01 (2022): 1–7. http://dx.doi.org/10.54482/probilitas.v1i01.80.

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Sars-Cov-2 which was first identified at the end of 2019 due to Corona Virus infection is still a worldwide pandemic because there is no specific drug that can fight this virus. Several problems, such as the performance of the vaccine that functions to relieve symptoms of Sars-Cov-2 virus infection, have sparked a new view of alternative medicine through natural ingredients as an alternative treatment for this viral infection. The chemical compound Zingiber officinale has potential as an antitussive, but its specific performance is unknown. So in this study, we will predict the molecular mecha

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Orlova, N. V. "Complex therapy of acute respiratory diseases." Medical Council, no. 15 (December 8, 2019): 91–97. http://dx.doi.org/10.21518/2079-701x-2019-15-91-97.

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Acute respiratory disease (ARD) is a common pathology. Untimely diagnosis and treatment, co-morbidities, old age and children under 1 year of age, pregnancy can increase the severity of the condition and lead to complications and death. According to IDSA recommendations, vaccination is an effective way to prevent complications and fatal influenza cases. Vaccination is primarily for people at risk of serious illness. In cases of suspected influenza, molecular diagnostics is recommended. At the same time, treatment of suspected influenza should be prescribed immediately, without waiting for labo

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Seliuk, Mariana, Mykola Kozachok, Svitlana Bychkova, et al. "Modern Treatment of Dry Post-viral Cough. Focus on Efficiency and Safety." Family medicine. European practices, no. 1 (February 29, 2024): 32–38. http://dx.doi.org/10.30841/2786-720x.1.2024.300462.

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Cough is the most common symptom of bronchopulmonary diseases, about which patients consult the doctors of both primary and secondary care. Cough can be caused by diseases of the respiratory tract, digestive tract, and cardiovascular diseases. However, cough most often develops during acute respiratory viral infections (ARVI), which disrupts the patient’s normal activities and limits his work capacity. Since most respiratory infections are viral in nature, the use of antibacterial drugs will not only be of no benefit, but will also significantly worsen the patient’s condition. The objective: t

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Seliuk, Mariana, Mykola Kozachok, Svitlana Bychkova, et al. "Modern Treatment of Dry Post-viral Cough. Focus on Efficiency and Safety." Family Medicine. European Practices, no. 1 (February 29, 2024): 32–38. https://doi.org/10.30841/2786-720X.1.2024.300462.

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Cough is the most common symptom of bronchopulmonary diseases, about which patients consult the doctors of both primary and secondary care. Cough can be caused by diseases of the respiratory tract, digestive tract, and cardiovascular diseases. However, cough most often develops during acute respiratory viral infections (ARVI), which disrupts the patient’s normal activities and limits his work capacity. Since most respiratory infections are viral in nature, the use of antibacterial drugs will not only be of no benefit, but will also significantly worsen the patient’s condition. <str

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28

Orlova, N. V. "Chronic cough: differential diagnosis and treatment." Meditsinskiy sovet = Medical Council, no. 17 (November 22, 2020): 124–31. http://dx.doi.org/10.21518/2079-701x-2020-17-124-131.

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Cough is one of the most common symptoms and is present in diseases of the respiratory, cardiovascular, digestive, endocrine and other systems. Cough is a reflex act, therefore it is caused by stimulation of cough receptors due to pathological influences. The diagnosis takes into account the nature of the cough, its duration, the results of laboratory and instrumental examination methods. The most attention is required to diagnose chronic cough and exclude life-threatening causes. Symptoms of anxiety are hemoptysis, prolonged resistant cough, prolonged intoxication syndrome, weight loss, etc.

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Kamei, Junzo, Yutaka Kasuya, and Takehiko Hukuhara. "Possible involvement of serotonergic systems in the central mechanisms of antitussive drugs." Japanese Journal of Pharmacology 43 (1987): 81. http://dx.doi.org/10.1016/s0021-5198(19)58048-9.

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30

Ajay, Laware* Gopal Chavhan Vaishnavi Tawde Swati Deshmukh. "Formulation And Evaluation of Polyherbal Antitussive Cough Syrup." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3924–35. https://doi.org/10.5281/zenodo.15497316.

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The current study is centered on the development and scientific evaluation of a polyherbal antitussive cough syrup formulated using multiple medicinal herbs with established ethnomedicinal use in respiratory disorders. The growing resistance to synthetic drugs and their associated side effects, such as sedation and gastrointestinal discomfort, have driven increased interest in herbal remedies. The plants selected for this formulation—Glycyrrhiza glabra (Liquorice), Zingiber officinale (Ginger), Adhatoda vasica (Vasaka), Ocimum sanctum (Tulsi), Mentha piperita (Peppermint), and Syzygium a

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31

Welch, Leisa, and Robert Sovner. "The Treatment of a Chronic Organic Mental Disorder with Dextromethorphan in a Man with Severe Mental Retardation." British Journal of Psychiatry 161, no. 1 (1992): 118–20. http://dx.doi.org/10.1192/bjp.161.1.118.

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Response to dextromethorphan (15 mg b.i.d.), an antitussive agent not usually considered to have psychotropic properties, was seen in a 25–year-old man with severe developmental disabilities, congenital rubella, and an organic mental disorder. Dextromethorphan affects CNS serotonergic systems, and this was the probable therapeutic mechanism. This and other published cases suggest the existence of a distinct organic mental syndrome in developmentally disabled persons which responds to drugs that increase indoleaminergic activity.

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Yamamoto, Gen, Fumio Soeda, Tetsuya Shirasaki, and Kazuo Takahama. "Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats." Canadian Journal of Physiology and Pharmacology 87, no. 11 (2009): 893–99. http://dx.doi.org/10.1139/y09-078.

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We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague–Dawley rats. Cerebral infarction was then induced by occlusion of the left middle cerebral artery. Twenty-four hours after cerebral infarction, the effect of each drug on micturition disorder was estimated for 5 parameters: bladder capacity, maximum voiding pressure, micturition latency, flow rate, and urethral resistance. Cerebral i

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33

Mutolo, Donatella, Elenia Cinelli, Fulvia Bongianni, and Tito Pantaleo. "Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 11 (2014): R1358—R1367. http://dx.doi.org/10.1152/ajpregu.00237.2014.

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The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related afferents and a strategic site for the modulation of the cough reflex. The similarities between the characteristics of central processing of nociceptive and cough-related inputs led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, could also be involved in the regulation of the cough reflex at the level of the NTS, where galanin receptors have been found. We investigated the effects of galanin and galnon, a nonpeptide agonist at galanin receptors, on cough responses to mecha

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Mutolo, Donatella, Fulvia Bongianni, Elenia Cinelli, Giovanni A. Fontana, and Tito Pantaleo. "Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 1 (2008): R243—R251. http://dx.doi.org/10.1152/ajpregu.00184.2008.

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We have previously shown that ionotropic glutamate receptors in the caudal portion of the nucleus tractus solitarii (NTS), especially in the commissural NTS, play a prominent role in the mediation of tracheobronchial cough and that substance P potentiates this reflex. This NTS region could be a site of action of some centrally acting antitussive agents and a component of a drug-sensitive gating mechanism of cough. To address these issues, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30–50 nl)

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35

Husain, Mazhar, M. Zaigham, Hamiduddin ., Abdul Wadud, and Mohd Akhtar Ali. "A REVIEW ON PHARMACOLOGICAL AND PHYTOCHEMICAL PROFILE OF KHATMI (ALTHAEA OFFICINALIS LINN.): AN IMPORTANT MUCILAGINOUS PLANT AND ITS UTILIZATION IN UNANI SYSTEM OF MEDICINE." International Journal of Research in Ayurveda and Pharmacy 12, no. 3 (2021): 63–72. http://dx.doi.org/10.7897/2277-4343.120376.

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Traditional medicines / drugs are helpful for management of life style disorders and chronic and acute diseases. Khatmi (Althea officinalis Linn.) is a one of the commonly used drugs that has potential for management of many diseases. The meaning of Khatmi (Marshmallow) is Kaseer-al-manafe (Multi actions) in Unani literature. Roots, flowers and seeds of Khatmi are used as a medicament. According to Unani texts the main actions of Khatmi are demulcent, expectorant, defragment, concoctive, astringent, detergent and repellent. It is also used as part of many traditional recipes. Analgesic, emolli

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Kamei, Junzo. "δ-Opioid Receptor Antagonists as a New Concept for Central Acting Antitussive Drugs". Pulmonary Pharmacology & Therapeutics 15, № 3 (2002): 235–40. http://dx.doi.org/10.1006/pupt.2002.0350.

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37

Taranushenko, Т. Е. "Cough in children: issues of diagnosis and rational therapy." Medical Council, no. 17 (November 24, 2019): 100–106. http://dx.doi.org/10.21518/2079-701x-2019-17-100-106.

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The presented review is devoted to topical issues of managing patients with cough, includes literature data on epidemiology, clinical classification, analysis of the causes, and the necessary diagnostic methods and lines of cough pharmacotherapy in children. The article focuses on the differential diagnosis of various pathological conditions and diseases, where cough is the leading clinical sign. The author provides information on treatment and characteristics of drugs recommended for symptomatic therapy of cough and indicates principles for rational antitussive and mucoactive pharmacotherapy.

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Mizernitskiy, Yu L., and I. M. Melnikova. "Persistent and prolonged cough in children: differential diagnosis and treatment algorithms." Medical Council, no. 17 (November 24, 2019): 58–75. http://dx.doi.org/10.21518/2079-701x-2019-17-58-75.

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The article presents data on the etiology, modern methods for diagnosis and treatment of respiratory system diseases and examines in detail cough as the main symptom. Particular attention is paid to hypertussivity, which is defined as a cough that occurs in the absence of obvious reasons. In addition, the emphasize was put on the role of anatomical and physiological features in the development and characteristics of cough, especially in young children. The authors draw attention to the complex mechanism of the cough, which development involves many body systems such as nervous, immune, endocri

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Orlova, N. V. "The place of phytotherapy in the treatment of acute upper respiratory tract infections." Meditsinskiy sovet = Medical Council, no. 20 (November 16, 2022): 65–71. http://dx.doi.org/10.21518/2079-701x-2022-16-20-65-71.

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Phytotherapy is based on the use of herbal medicines. Treatment with phytopreparations is characterized by efficiency, low risk of adverse events and the ability to enhance the effect of complex therapy. Herbal preparations are subject to standard requirements for quality control, safety and effectiveness. Inflammatory diseases of the respiratory tract are characterized by numerous symptoms that significantly reduce the quality of life of the patient. Along with pathogenetic therapy, symptomatic treatment is used. For the treatment of respiratory diseases, phytopreparations with antipyretic, i

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40

Xu, Yang, Fang Wang, Hongye Guo, et al. "Antitussive and Anti-inflammatory Dual-active Agents Developed from Natural Product Lead Compound 1-Methylhydantoin." Molecules 24, no. 13 (2019): 2355. http://dx.doi.org/10.3390/molecules24132355.

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Natural products play an important role in drug discovery. This work employed a natural product 1-methylhydantoin as the lead compound to develop novel dual-active drugs. 1-Methylhydantoin was isolated from Oviductus Ranae, which is a traditional Chinese medicine that has been used for tussive and inflammation treatment for a long time. An in silico study screened the more active 1-methylhydantoin derivatives. Antitussive assessment indicated that the newly synthesized agent had similar bioactivity with the natural product. An anti-inflammatory model used xylene induced ear edema model. At the

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Uwaya, Dickson Onyenmulo, and Offiong Nnom Effiong. "Quantification of Phytochemical Constituents, and Non-Enzymatic Antioxidants of Polyherbal-Formulated Tea on Antitussive, Expectorant, and Analgesic Activity in Rodent." Research in Biotechnology and Environmental Science 3, no. 1 (2024): 9–17. http://dx.doi.org/10.58803/rbes.v3i1.29.

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Introduction: Polyherbal formulations maximize therapeutic effects and reduce toxicity by combining effective herbs in specific ratios. The present study aimed to quantify some phytochemical constituents, and some non-enzymatic antioxidants and to estimate the analgesic, expectorant, and antitussive properties of polyherbal-formulated tea (Curcuma longa, Citrus limon, Zingiber officinale, Allium sativum, and Moringa oleifera). Materials and Methods: Some phytochemical constituents and some non-enzymatic antioxidants of the polyherbal tea were evaluated using colorimetric methods. The antitussi

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Kara, Mehmet, and Esma Yıldırım. "COVID-19 Pandemic: Changes in Drug Consumption and Implications for Treatment Strategies." Medical Science and Discovery 10, no. 7 (2023): 466–71. http://dx.doi.org/10.36472/msd.v10i7.984.

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Objective: This study aims to establish a roadmap for drug supply during potential future pandemic scenarios by examining the variations in drug consumption at Kayseri City Training and Research Hospital during the COVID-19 pandemic compared to the pre-COVID-19 period. Materials and Methods: The study involved an analysis of one-year drug stock data before and after the pandemic. The start date of the pandemic was identified as April 2020 when the first COVID-19 case was admitted to our hospital. Data on drug stock inputs and outputs were obtained from the Hospital Information Management Syste

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Zaremba, Malgorzata, Pawel Serafin, and Patrycja Kleczkowska. "Antipsychotic Drugs Efficacy in Dextromethorphan-Induced Psychosis." Biomedicines 11, no. 1 (2023): 123. http://dx.doi.org/10.3390/biomedicines11010123.

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Psychosis is known as a broad term of symptoms that cause serious disorganization of behavior, thinking, and perception of reality. One of the medicines that recently gained much attention in terms of its psychotic potential is dextromethorphan (DXM). DXM, a widely used antitussive drug, is a commonly abused drug because of its euphoric, hallucinogenic, and dissociative properties. To date, DXM is a legally marketed cough suppressant that is neither a controlled substance nor a regulated chemical under the Controlled Substances Act. The management of DXM-related psychosis is dependent on the t

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Thapliyal, Neeta, Harun Patel, Rajshekhar Karpoormath, Rajendra N. Goyal, and Rajkumar Patel. "A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs." Talanta 142 (September 2015): 157–63. http://dx.doi.org/10.1016/j.talanta.2015.04.061.

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Kucherenko, N. G., A. K. Ratnikova, V. B. Grinevich, E. I. Tkachenko, and Yu A. Kravchuk. "Clinic and semiotics of digestive lesions with coronavirus SARS-CoV-2." Experimental and Clinical Gastroenterology, no. 2 (April 7, 2021): 20–26. http://dx.doi.org/10.31146/1682-8658-ecg-186-2-20-26.

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The article presents the results of the analysis of clinical features of gastroenterological manifestations of a new coronavirus infection (COVID-19) caused by the pathogen SARS-CoV-2. Taking into account the stage-by-stage system assessment of the experience of treating 1,180 patients in a multi-specialty hospital transformed into an infectious hospital, the most characteristic clinical manifestations of digestive damage by SARS-CoV-2 coronavirus are described. The article focuses on verification of changes in the digestive system, both at the stage of primary examination, and during etiotrop

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Yu, Huiqing, Mengting Chen, Junhui Zhang, and Hong Yang. "Efficacy of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer cough." Journal of Clinical Oncology 42, no. 16_suppl (2024): e20548-e20548. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20548.

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e20548 Background: To assess the therapeutic effect of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer cough. Methods: A total of 60 patients with diagnosed middle-advanced stage lung cancer accompanied with lung cancer cough from Jan, 2022 to May, 2022 were enrolled . According to the method of random number table, the patients were divided into two groups: observation group and control group. Observation group received compound pholcodine syrup treatment, while control group received compound codeine phosphate oral solution treatment. The dosage of the t

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Karegar-Borzi, Hossein, Mehdi Salehi, and Roja Rahimi. "Laūq." Journal of Evidence-Based Complementary & Alternative Medicine 21, no. 1 (2015): 63–70. http://dx.doi.org/10.1177/2156587215587417.

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Laūq is a pharmaceutical dosage form that had been mainly used for the treatment of various respiratory disorders in traditional Persian medicine. It is important from 2 aspects: a dosage form with efficient and optimum delivery of drugs to the respiratory tract and biological effects of its ingredients. Natural medicine in laūq has been demonstrated to act in respiratory disorders by their antitussive, antiallergic, anti-inflammatory, antioxidant, spasmolytic, and antibacterial activities. Some of these natural remedies act by most of the mentioned mechanisms such as Cydonia oblonga, Glycyrrh

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Pourova, Jana, Patricia Dias, Milan Pour, et al. "Proposed mechanisms of action of herbal drugs and their biologically active constituents in the treatment of coughs: an overview." PeerJ 11 (October 24, 2023): e16096. http://dx.doi.org/10.7717/peerj.16096.

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Various medicinal plants find their use in cough treatment, based on traditions and long-term experience. Pharmacological principles of their action, however, are much less known. Herbal drugs usually contain a mixture of potentially active compounds, which can manifest diverse effects. Expectorant or antitussive effects, which can be accompanied by others, such as anti-inflammatory or antibacterial, are probably the most important in the treatment of coughs. The aim of this review is to summarize the current state of knowledge of the effects of medicinal plants or their constituents on cough,

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Zaicev, A. A., E. V. Bolotova, A. V. Dudnikova, et al. "Results of an open observational multicenter study of the effectiveness and tolerability of levodropropizine in comparison with standard antitussive therapy (real practice) in the treatment of patients with COVID-19." PULMONOLOGIYA 32, no. 4 (2022): 548–57. http://dx.doi.org/10.18093/0869-0189-2022-32-4-548-557.

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Cough is one of the most common symptoms of COVID-19 (COronaVIrus Disease-2019), occurring in more than 70% of cases. The cough associated with the new coronavirus infection tends to be non-productive and requires symptomatic antitussive therapy. However, at present, there is insufficient data on the effectiveness of various antitussive agents in COVID-19.The aim. Analysis of the clinical and economic efficiency and safety of the use of levodropropizin in comparison with standard symptomatic therapy of patients with a new coronavirus infection COVID-19 in the real-life clinical setting.Methods

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Takahama, Kazuo, Tetsuya Shirasaki, and Jian Rong Zhou. "Lower airway nervous system as a putative target of antitussive drugs effective for treatment of chronic cough." Folia Pharmacologica Japonica 131, no. 6 (2008): 423–28. http://dx.doi.org/10.1254/fpj.131.423.

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