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Journal articles on the topic 'Antiulcer modals'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Sruthi, Y.* Dr. Vishnu Kangralkar. "A Comprehensive Review of Experimental Models, Evaluation Parameters, And Natural-Synthetic Therapeutics for Peptic Ulcer Treatment." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 929–46. https://doi.org/10.5281/zenodo.15350568.

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Peptic ulcer disease (PUD) is a gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid and pepsin, and the protective mechanisms of the gastrointestinal mucosa. Common causes include Helicobacter pylori infection, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), alcohol intake, smoking, and dietary imbalances. Conventional therapeutic approaches, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists, have proven effective but are often associated with adverse effects, drug interactions, and high recurrence ra

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2

Mishra, Abhinav P., Ankit Bajpai, and Suresh Chandra. "A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antiulcer Drugs." Current Clinical Pharmacology 14, no. 3 (2019): 175–96. http://dx.doi.org/10.2174/1574884714666190312143846.

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Background:Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs and sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that cause pain. Another condition that synergizes the abdominal pain is vomiting materials which look like coffee grounds, blood in the stool, blac

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3

Rameshwari, K. sudha, and Ayshwarya M. "EVALUATION OF ANTIULCEROGENIC ACTIVITY OF METHANOL EXTRACTS OF BRASSICA OLERACEA VAR. CAPITATA RUBRA ON ALBINO RAT GASTRIC ULCERATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 314. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16217.

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ABSTRACTObjective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats.Methods: To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously.The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index.Results: The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The controlanimals had ulcers and hemo

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Srikanth, J., and P. Muralidharan. "Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract." Journal of Scientific Research 1, no. 2 (2009): 345–52. http://dx.doi.org/10.3329/jsr.v1i2.1625.

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The study was designed to investigate the antiulcer activity of ethyl acetate extract of the fruits of Morinda citrifolia Linn (Rubiaceae) using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation and duodenal ulcers were induced by oral administration of cysteamine HCl. The extract was administered at a dose of 200 and 400 mg/kg orally 30 min prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard. The antiulcer activity was accessed by determining and comparing the

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5

Goulart, Yara Cavalcante Fortes, Vania Ramos Sela, Simoni Obici, et al. "Evaluation of gastric anti-ulcer activity in a hydro-ethanolic extract from Kielmeyera coriacea." Brazilian Archives of Biology and Technology 48, no. 2 (2005): 211–16. http://dx.doi.org/10.1590/s1516-89132005000200007.

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The antiulcer activity of a hydro-ethanolic extract prepared from the stems of Kielmeyera coriacea Mart. (Guttiferae) was evaluated in rats employing the ethanol-acid, acute stress and Indomethacin models to induce experimental gastric ulcers. Treatment with K coriacea hydro-ethanolic extract provided significant antiulcer protection in the ethanol-acid and Indomethacin models, but not in the acute stress model. These results suggested that the K coriacea hydro-ethanolic extract increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa.

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Mekonnen, Alefe Norahun, Seyfe Asrade Atnafie, and Mohammedbirhan A. Wahab Atta. "Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents." Evidence-Based Complementary and Alternative Medicine 2020 (April 9, 2020): 1–11. http://dx.doi.org/10.1155/2020/2809270.

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Background. Peptic ulcer disease causes significant mortality and morbidity. Plant kingdom provides a useful source for the development of new antiulcer agents. Croton macrostachyus is traditionally used to treat peptic ulcer in Ethiopia. This study aimed to evaluate the antiulcer activity of C. macrostachyus root extracts in rodents using different models. Methods. The crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water. The antiulcer activity was evaluated using pylorus ligation-induced ulcer model in Sprague Dawl

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7

Thi, Xuan Bui, Loi Vu Duc, Tung Bui Thanh, and Ngoc Tran Minh. "Chemical Constituents and Antiulcer Activity of n-Hexane Extract of Sanchezia nobilis Hook F. Leaves from Vietnam." Asian Journal of Chemistry 31, no. 9 (2019): 2125–32. http://dx.doi.org/10.14233/ajchem.2019.22156.

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Five compounds (1-5) were isolated from the leaves of Sanchezia nobilis collected in Nam Dinh province by chromatographic methods. These compounds were identified as: mangiferin (1), β-sitosterol (2), margaric acid (3), ursolic acid (4), oleanolic acid (5). Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. These compounds were isolated from the leaves of Sanchezia nobilis for the first time. Screening of gastric and duodenal antiulcer effects on indomethacin induced gastric ulcer models showed that n-hexane fraction produced

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8

Saleem, Uzma, Ejaz Ul Haq, Bashir Ahmad, and Mohammad Saleem. "Anti-ulcer activity of Cestrum nocturnum leaf in ethanol- and indomethacin-induced ulcer models." Bangladesh Journal of Pharmacology 12, no. 3 (2017): 335. http://dx.doi.org/10.3329/bjp.v12i3.32790.

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<p class="Abstract">This study was planned to explore the antiulcer activity of the methanolic and <em>n</em>-hexane extracts of <em>Cestrum nocturnum</em> leaf against ethanol- and indomethacin-induced ulcer models in rats. The rats were administered orally vehicle in normal control group, methanolic and <em>n</em>-hexane extracts at doses 300, 500, 700 mg/kg, in treated groups and omeprazole 20 mg/kg, as standard drug. The gastric tissues/contents were examined to determine the ulcer index, antiulcer activity, gastric pH, gastric juice volume and aci

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9

Hemamalini, K., Y. Ramulu, and B. Rambabu. "Protective Effect of Raphanus sativus Using by Phytochemical and Antiulcer Activity by Aspirin Induced Gastric Ulcer." Journal of Pharmaceutical Research International 37, no. 1 (2025): 83–89. https://doi.org/10.9734/jpri/2025/v37i17650.

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Raphanus sativus, a widely growing, has been used in traditional medicine for treating many ailments. The objective of the present study was to evaluate the effects of Aspirinic extract of R. Sativus leaves on gastric ulcer. The antiulcer effects of MERS at 100 and 200 mg/kg doses were evaluated on Aspirin gastric ulcer models. The histological changes in gastric tissue of ulcer mice were also determined in aspirin induced models. R. sativus treatment significantly (P < 0.01) reduced the ulcer index and significantly (P < 0.01) increased the gastric pH of both Aspirin and aspirin-induced

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Deshpande, Mangirish, Pearl Dighe, and Sujit Nagare. "A Review of Antiulcer Activity of Some Medicinal Plants." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 201–13. http://dx.doi.org/10.22270/jddt.v14i8.6722.

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Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from

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11

Alka Zade, Jugalkishore Vyas, Vivek Paithankar, and Anjali Wankhede. "Evaluation of antiulcer activity of herbal drugs on experimental animal: Myrica nagi (Myricaceae)." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 138–44. http://dx.doi.org/10.30574/gscbps.2022.20.2.0326.

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The anti-ulcer activity of Methanolic extract of Myrica nagi (Myricaceae) fruit MEMN was investigated in pylorus ligation and methanol-induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index MEMN at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Aspirin-induced ulcers & pylorus ligation-induced ulcers. The extract (200, 400 mg/kg) showed a significant (P < 0.001) reduction in gastric volume, free acidity and ulcer index as compared to the control. This present study indicates that Myrica nagi frui

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12

Agbaje, Esther Oluwatoyin, and Yewa Peace Doe. "Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models." Journal of Phytopharmacology 4, no. 5 (2015): 268–75. http://dx.doi.org/10.31254/phyto.2015.4506.

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The plant Dialium guineense (DAG) has been claimed by local users, to be effective in the treatment of peptic ulcers, especially, when taken as an aqueous decoction. The present study assessed the antiulcer activity of the plant, as well as explored the possible mechanisms of action of the herbal drug, aside identifying some of the various phytoconstituents, which could be responsible for its antiulcer activity. Different ulcerogens (ethanol 99.9 %, indomethacin 50 mg/kg, cysteamine 400 mg/kg, glacial acetic acid) and the pylorus ligation-induced ulcers were used to induce acute and chronic ul

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13

Alka, Zade, Vyas Jugalkishore, Paithankar Vivek, and Wankhede Anjali. "Evaluation of antiulcer activity of herbal drugs on experimental animal: Myrica nagi (Myricaceae)." GSC Biological and Pharmaceutical Sciences 20, no. 2 (2022): 138–44. https://doi.org/10.5281/zenodo.7139688.

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The anti-ulcer activity of Methanolic extract of <em>Myrica nagi</em> (Myricaceae) fruit MEMN was investigated in pylorus ligation and methanol-induced ulcer models in Wistar rats. In both models, the common parameter determined was ulcer index MEMN at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Aspirin-induced ulcers & pylorus ligation-induced ulcers. The extract (200, 400 mg/kg) showed a significant (P < 0.001) reduction in gastric volume, free acidity and ulcer index as compared to the control. This present study indicates th

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14

Hulinská, Hana, Zdeněk Polívka, Jiří Jílek, et al. "Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1820–44. http://dx.doi.org/10.1135/cccc19881820.

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Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)-dibenz[b,f]azepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V-XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I). Contributions to the syntheses and characterization of mianserin (XIX),

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15

Hasan, Afrida, Md Aktaruz zaman, Nafisa Tabassum, and Rayhan Ahmed. "A Review of the Phytochemicals Found in Medicinal Plants that may have Antiulcer Properties." Middle East Research Journal of Pharmaceutical Sciences 4, no. 05 (2024): 59–64. http://dx.doi.org/10.36348/merjps.2024.v04i05.001.

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The risk of peptic ulcer is also increased by non-steroidal anti-inflammatory medications and Helicobacter pylori infection. Adverse effects and concurrent usage of antibiotics result from the careless use of synthetic medicines. Compounds drug-drug interactions; thus, it is vital to look for medications made from natural sources, particularly plants. Numerous ulcer-inducing models in lab animals have been used to assess the antiulcer effectiveness of numerous herbal remedies. The current study is to examine putative medicinal plants with gastro-protective and ulcer-healing properties and comp

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16

PA, Akah. "Evaluation of the Gastric Antiulcer Efficacy of Helianthus annuus L, Leaves Extract and Fractions." Journal of Natural & Ayurvedic Medicine 4, no. 2 (2020): 1–9. http://dx.doi.org/10.23880/jonam-16000251.

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Peptic ulcer disease is one of the most common gastrointestinal diseases worldwide. Its treatment is becoming increasingly difficult due to the implication of Helicobacter pylori and its increasing resistance to antimicrobial agents leading to a cyclical course of exacerbation and remission. This study evaluated the antiulcer effects of methanol leaf extract and fractions of Helianthus annuus. The crude extract was prepared by cold maceration with methanol. A portion of the extract (300 g) was partitioned with n-hexane, ethyl acetate and methanol to yield n-hexane (HF), ethyl acetate (EF) and

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17

Adinortey, Michael Buenor, Charles Ansah, Isaac Galyuon, and Alexander Nyarko. "In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents." Ulcers 2013 (June 25, 2013): 1–12. http://dx.doi.org/10.1155/2013/796405.

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Peptic ulcer is among the most serious gastrointestinal diseases in the world. Several orthodox drugs are employed for the treatment of the disease. Although these drugs are effective, they produce many adverse effects thus limiting their use. In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side effects, ease of accessibility, and affordability. Plant medicines with ethnomedicinal use in peptic ulcer management need to be screened for their effectiveness and possible isolation of lead compounds. Thi

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18

Khare, Basant, Naina Dubey, and Akash Sharma. "ANTIULCER ACTIVITY OF CONTROLLED RELEASE FORMULATION CONTAINING AQUEOUS EXTRACT OF ACACIA CATECHU WILLD ON RODENT MODELS." International Journal of Current Pharmaceutical Research 10, no. 5 (2018): 25. http://dx.doi.org/10.22159/ijcpr.2018v10i5.29689.

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Objective: To study the Antiulcer activity of aqueous extract of acacia catechu willd on rodent models by controlled release formulation.Methods: Microspheres were prepared by solvent evapoaration method and were evaluated for various parameters like SEM, stability and in vitro relese. And acacia catechu willd loaded microspheres were evaluated for in vivo study involving Gastric ulceration in rats was induced by Ethanol/HCl. Ulcer genic effect (Ulcer Index), pH and Total acidity, Histopathological studies.Results: Results indicated that Acacia catechu willd microspheres contains some active c

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YANO, Shingo, Masatoshi HARADA, Kazuo WATANABE, et al. "Antiulcer activities of glycyrrhetinic acid derivatives in experimental gastric lesion models." CHEMICAL & PHARMACEUTICAL BULLETIN 37, no. 9 (1989): 2500–2504. http://dx.doi.org/10.1248/cpb.37.2500.

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Suba, V., T. Murugesan, M. Pal, Subhash C. Mandal, and B. P. Saha. "Antiulcer activity of methanol fraction ofBarleria lupulina Lindl. in animal models." Phytotherapy Research 18, no. 11 (2004): 925–29. http://dx.doi.org/10.1002/ptr.1587.

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Upadhyay, Srishti, Jagdish Nagar, and Mohammad Mukim. "Pharmacognostical Standardization, Phytochemical Screening and Antiulcer Activity of Terminalia bellerica." Asian Journal of Pharmaceutical Research and Development 10, no. 2 (2022): 125–37. http://dx.doi.org/10.22270/ajprd.v10i2.1119.

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Context: Terminalia chebula Retz. (Combretaceae) is a medium-sized tree that grows in the wild throughout India. T. chebula has been extensively used in Ayurveda, Unani, and homoeopathic medicine. The fruit has been used as a traditional medicine for a household remedy against various human ailments. Traditionally T. chebula is used to cure chronic ulcer, gastritis, and stomach cancers. Objective: The present study is to evaluate the antiulcer effect of hydroalcoholic extract of Terminalia chebula fruit. Materials and methods: In the pharmacognostical, phytochemical and biological

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22

Fulga, Simona, Ana-Maria Pelin, Cristina Mihaela Ghiciuc, and Elena Cătălina Lupușoru. "Particularities of Experimental Models Used to Induce Gastric Ulcer." ARS Medica Tomitana 25, no. 4 (2019): 179–84. http://dx.doi.org/10.2478/arsm-2019-0035.

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Abstract Introduction: Gastric ulcer is one of the most common gastrointestinal diseases, therefore the constant interest for new treatments is due to adverse effects induced by current therapy. The restricted number of in vivo experimental models is a challenge for researchers. Objectives: Identifying the particularities of different types of experimentally induced gastric ulcer in laboratory animals to facilitate their choise for the study of new antiulcer drugs. Material and method: A search in PubMed and Scopus using keywords ( “experimentally” AND “gastric ulcer” AND “rats/mice”) to inclu

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Srivastava, Vivek, Santosh Kumar Verma, Neha Mathur, and Kapil Kumar Goel. "Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats." Journal of Applied and Natural Science 13, no. 1 (2021): 308–15. http://dx.doi.org/10.31018/jans.v13i1.2513.

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Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model

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Jadhav, Rupali V., V. K. Redasani, Shankar B. Kalbhare, Karishma Yadav, Aryan Langeh, and Amuruta Tidke. "Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats." International Journal of Research in Medical Sciences 9, no. 5 (2021): 1412. http://dx.doi.org/10.18203/2320-6012.ijrms20211878.

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Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significa

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Syed, Safiullah Ghori* Mohd Firdousuddin Amer &Shazia Siddiqa. "ANTIULCER POTENTIAL OF FICUS DALHOUSIAE STEM BARK METHANOLIC EXTRACT IN ALBINO RATS." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1096–101. https://doi.org/10.5281/zenodo.163851.

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The aim of the present study was to evaluate the antiulcer potential of Ficus Dalhousiae stem bark methanolic extract by excision and incision experimental models. Aalbino rats weighing 180 - 200 gm were utilised for the study. The preliminary phytochemical screening of the methanolic extract of stem bark showed the presence of various phytoconstituents namely alkaloids, flavanoids glycosides, saponins, sterols and tannins. Aspirin induced and ethanol induced gastric ulcers has been widely used for the experimental evaluation of antiulcer activity. Aspirin induced and ethanol induced gastric l

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Sarwade, Prakash Pralhad, Kavita Narayan Gaisamudre (Sarwade), Santosh Kumar S.R., Manoj Manjunath Bongale, Mihir Otia, and Chandresh Maurya. "Psidium guajava It's Botanical Description, Phytochemistry, Pharmacological Activities and It's Role in Antiulcer Activity." Journal for Research in Applied Sciences and Biotechnology 4, no. 3 (2025): 35–44. https://doi.org/10.55544/jrasb.4.3.5.

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Psidium guajava L., commonly known as guava, is a widely distributed tropical and subtropical plant belonging to the family Myrtaceae. It has been traditionally used in folk medicine for the treatment of a variety of ailments, particularly gastrointestinal disorders. This plant has attracted considerable scientific interest due to its rich phytochemical profile and broad pharmacological properties. The present review aims to provide a comprehensive overview of the botanical characteristics, chemical constituents, pharmacological activities, and specifically the antiulcer potential of Psidium g

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Amazu, Louis U., Bassey S. Antia, and Jude E. Okokon. "Antiulcerogenic activity of Solenostemon monostachyus." Journal of Phytopharmacology 4, no. 2 (2015): 97–101. http://dx.doi.org/10.31254/phyto.2015.4207.

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Objective: Solenostemon monostachyus P. Beauv (family Lamiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer activity. Materials and Methods: The effects of extract of Solenostemon monostachyus (75 - 225 mg/kg) and fractions (Aqueous and chloroform, 150 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results: The effect of ethanol extract of S. monostachyus (75 – 225 mg/kg) and fractions on experimentally i

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Kumar, Arun, Nitin Kumar, Rahul Shukla, and Anurag Chaudhary. "Antiulcer activity of ethanolic extract of Sesamum Indicum on experimental animal models." Asian Journal of Pharmacy and Pharmacology 5, no. 6 (2019): 1144–51. http://dx.doi.org/10.31024/ajpp.2019.5.6.10.

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Mikwangock, Hauberline Domegne, Alfred Ngenge Tamfu, André Perfusion Amang, et al. "Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon." BioMed Research International 2023 (January 9, 2023): 1–19. http://dx.doi.org/10.1155/2023/2657278.

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Aim. This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats. Materials and Methods. Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of Corchorus olitorius, Solanum nigrum, Vigna unguiculata, Triumfetta pentandra, “nkui” spices, and “yellow soup” spices were tested at two doses (200 and 400 mg/kg). After treatments, animals were sacrificed, healing percentage and antio

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Offor, Samuel, Adedayo Adedoyin Tologbonse, Sifon Obong John Akpan, Victor Udo Anah, and Enobong Anietie Edward. "Evaluation of the Anti-ulcer Effect of Extra Virgin Avocado (Persea americana) Oil in Rats." European Journal of Pharmaceutical Research 2, no. 1 (2022): 1–5. http://dx.doi.org/10.24018/ejpharma.2022.2.1.15.

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Peptic ulcer disease is a gastrointestinal disorder of high mortality and morbidity. Therapy of this disease condition with conventional drugs presents therapeutic challenge due to incidents of unwanted side effects, and the high cost of these medications. The use of products from natural sources will provide useful alternatives due to their minimal side effects, being inexpensive, and readily available, especially in resource-challenged nations of the continent of Africa and other developing economies. Oils derived from plants are increasingly being used in management of several disease condi

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Koshurba, I. V., F. V. Hladkykh, and M. O. Chyzh. "COMPARATIVE CHARACTERISTICS OF ANTIULCER ACTIVITY OF PLACENTAL CRYOEXTRACT UNDER DIFFERENT MODES OF APPLICATION IN THE EXPERIMENT." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 22, no. 2 (2022): 65–70. http://dx.doi.org/10.31718/2077-1096.22.2.65.

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Peptic ulcer disease is one of the most common diseases of the gastrointestinal tract worldwide. Among the causes of disability in the adult population, diseases of the digestive tract occupy the 5th place, and about 20.0–30.0% of them is peptic ulcer disease, which leads to permanent disability in more than 50.0% of patients. According to scientific reports, the prevalence of this pathology is due to its polyetiology, which leads to clinical heterogeneity and recurrent course. The aim of this study is to conduct a comparative assessment of the antiulcer effect of placental cryoextract in prop

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Sivaraman, D., and P. Muralidharan. "Cytoprotective Effect of Morinda tinctoria Roxb. against Surgical and Chemical Factor Induced Gastric and Duodenal Ulcers in Rats." Ulcers 2011 (December 25, 2011): 1–9. http://dx.doi.org/10.1155/2011/142719.

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The present paper relates to the pharmacological validation of the antiulcer efficacy of ethanol leaf extract of Morinda tinctoria Roxb. (EEMT) against aspirin pyloric ligation-induced gastric ulcer model and cysteamine-induced duodenal ulcer in Wistar rats. Oral administration of EEMT at a dose of 200 and 400 mg/kg significantly prevented the occurrence of aspirin pyloric ligation and cysteamine-induced gastric and duodenal ulceration. The volume and acidity of gastric juice in pyloric ligated rats were significantly () reduced by EEMT. There was a significant decrease in the number of ulcers

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Generalova, L. V., K. A. Kritskaya, D. P. Laryushkin, and E. A. Generalov. "Polysaccharide from Solanum tuberosum L. as a Potential Antiulcer Drug." Biofizika 69, no. 6 (2024): 1376–81. https://doi.org/10.31857/s0006302924060229.

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A study was conducted to investigate the antiulcer activity of the polysaccharide from Solanum tuberosum L. in chronic and acute ulcer models proposed by Selye and Okabe. The antiulcer effect was assessed by determining and comparing the ulcer index in the treated animals and a control. The groups of treated animals that received a daily administration of polysaccharide for 7 and 3 days showed a significant decrease in the ulcer index when compared with that of the control group of animals given physiological saline. In presence of polysaccharide, the incidence of pathological conditions (hype

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Vishnu, Patil* Mahesh Dhumal Shantanu Mane. "Evaluation Of Antiulcer Activity of Ativisha by Ethanol Induced Model on Experimental Animal." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1603–15. https://doi.org/10.5281/zenodo.14243215.

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The present study investigates the antiulcer activity of the ethanolic root extract of Aconitum heterophyllum (ERAH) in ethanol-induced ulcer models in albino Wistar rats. The study aimed to evaluate the ulcer index, ulcer score, and other related parameters such as pH, free acidity, and total acidity following the administration of different doses of ERAH (225 mg/kg, 450 mg/kg, and 900 mg/kg) and comparison with the standard drug Omeprazole (20 mg/kg). The findings revealed that ERAH demonstrated significant protection against ulcer formation, with a dose-dependent reduction in ulcer scores a

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Jaseela KP, Rakesh Kumar Jat, Subrata Kundu, and Sujith S Nair. "A REVIEW ON THE ANTIULCER POTENTIAL OF VARIOUS HERBAL EXTRACT IN DIFFERENT ANIMAL MODELS." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 24–32. https://doi.org/10.61280/tjpls.v12i1.175.

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Ulcers, particularly peptic ulcers, remain a significant health issue worldwide, primarily caused by factors like stress, Helicobacter pylori infection, excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs) and imbalances in gastric acid secretion. Although conventional medications like proton pump inhibitors and H2 antagonists are commonly used to treat ulcers, herbal remedies have garnered considerable attention due to their potential therapeutic benefits and minimal side effects. This review explores the antiulcer activity of various herbal extracts traditionally used in folk medic

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Anitha, Nandagopal. "Screening of antiulcer activity of lacidipine in experimentally induced ulcer models in rats." International Journal of Pharmacy Education and Research 1, no. 2 (2014): 28–32. http://dx.doi.org/10.17812/ijper/2014;1(2):28-32.

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S., Shree Lakshmi Devi, Abilash S. C., and Sengottuvelu S. "Evaluation of antiulcer and antioxidant potential of Ipomoea Reniformis leaf extract against experimentally induced ulcer in rats." International Journal of Basic & Clinical Pharmacology 6, no. 7 (2017): 1602. http://dx.doi.org/10.18203/2319-2003.ijbcp20172614.

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Background: Ulcer is a major disease of gastrointestinal system which affects about 10% of the world’s population. As conventional drugs can produce undesirable side effects on long term use it can be replaced by herbal medicines more safely. The study was designed to evaluate the antiulcer activity of ethanolic leaf extract of Ipomoea reniformis against pyloric ligated ulcer and cold restraint stress induced ulcer models in rats.Methods: Male Wistar albino rats were used. 0.1% Carboxy Methyl Cellulose (CMC) was used as vehicle. Ethanolic leaf extract of Ipomoea reniformis was employed at two

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Mohammed, Bala Alkali, Ali Audu Jigam, Abdulkadir Abubakar, Abdullahi Abdulkadir, and Mohammed Audu. "Antiulcerogenic activities of Agelanthus dodoneifolius leaf against acetyl salicylate and ethanol induced ulceration in rats." GSC Biological and Pharmaceutical Sciences 9, no. 1 (2019): 053–61. https://doi.org/10.5281/zenodo.4283341.

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Antiulcer and antioxidant activities of crude methanol (800 and 1600 mg/kg bw), n-hexane and ethyl acetate fractions (800 mg/kg bw) of <em>Agelanthus dodoneifolius</em> were investigated against acetylsalicylate and ethanol induced ulcer in rats.  The methanol fraction had the highest ulcer protective effect (73.33 ± 7.40%), better than the cimetidine (60.00±8.54 %) while the ethyl acetate fraction had the least (26.66 ± 6.66 %) in ethanol model, however, in acetyl salicylate model, crude extract exhibited the highest (54.16 ± 4.16 %) and the lowest (

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Rodrĺguez, Jaime A., Clélia A. Hiruma-Lima, and Alba RM Souza Brito. "Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara." Human & Experimental Toxicology 23, no. 9 (2004): 455–61. http://dx.doi.org/10.1191/0960327104ht473oa.

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The antiulcerogenic activity of trans-dehydrocrotonin (DHC), a nor-clerodane diterpene isolated from Croton cajucara Benth. (Euphorbiaceae), and its subacute (35 days) toxicity were studied in mice and rats, respectively. For the antiulcerogenic tests, models of gastric ulcers induced in mice by ethanol/HCl or stress were used. In both models, an oral dose of DHC (100 mg/kg) significantly reduced (P <0.01) the formation of gastric lesions. DHC was also tested for its ability to scavenge free radicals, but no such action was observed in rat liver mitochondria. To assess the subacute toxicity

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Andargie, Yared, Woretaw Sisay, Mulugeta Molla, Alefe Norahun, and Pradeep Singh. "Evaluation of the Antiulcer Activity of Methanolic Extract and Solvent Fractions of the Leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in Rats." Evidence-Based Complementary and Alternative Medicine 2022 (June 29, 2022): 1–12. http://dx.doi.org/10.1155/2022/4199284.

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Introduction. In Ethiopia, traditionally, the leaves of Calpurnia aurea have been utilized to treat peptic ulcer disease. Therefore, the objective of the present study was to examine the antiulcer activity of Calpurnia aurea hydromethanolic leaf extract and solvent fractions in rats. Methods. The ulcer-healing potential of the crude test extract was assessed in rats by adopting pyloric ligation-, acidified ethanol-, and acetic acid-induced ulcer methods; while, in solvent fractions, the acidified ethanol-induced ulcer model was used. In all models, three serial test doses (100, 200, and 400 mg

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Sathyanarayanan, Saikumar, Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, and Thangaraj Parimelazhagan. "Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats." Evidence-Based Complementary and Alternative Medicine 2022 (May 18, 2022): 1–14. http://dx.doi.org/10.1155/2022/4328571.

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Humans have been using herbs to prevent and cure various ailments since antiquity, and Ipomoea wightii is a significant medicinal plant known for its wide ethnobotanical uses. Although the plant is known to treat ulcers, there is no significant scientific validation. The present study aimed to assess the acute toxicity, subacute toxicity, and antiulcer properties of the leaf methanol extract of I. wightii (IWL). In the subacute study, the extracts were given orally at 100, 200, and 400 mg/kg doses for 28 days, and we analyzed the biochemical and histological parameters to evaluate the toxicity

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Asdaq, Syed Mohammed Basheeruddin, Earla Swathi, Sunil S. Dhamanigi, et al. "Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals." Molecules 25, no. 22 (2020): 5287. http://dx.doi.org/10.3390/molecules25225287.

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The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethac

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Kumar, Suresh, Suman, Sunil Sharma, and Pankaj Kalra. "Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models." Journal of Pharmacy and Bioallied Sciences 3, no. 2 (2011): 236. http://dx.doi.org/10.4103/0975-7406.80778.

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Bae, Dae-Kwon, Dongsun Park, Sun Hee Lee, et al. "Different Antiulcer Activities of Pantoprazole in Stress, Alcohol and Pylorus Ligation-Induced Ulcer Models." Laboratory Animal Research 27, no. 1 (2011): 47. http://dx.doi.org/10.5625/lar.2011.27.1.47.

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Palle, Suresh, A. Kanakalatha, and Ch N. Kavitha. "Gastroprotective and Antiulcer Effects ofCelastrus paniculatusSeed Oil Against Several Gastric Ulcer Models in Rats." Journal of Dietary Supplements 15, no. 4 (2017): 373–85. http://dx.doi.org/10.1080/19390211.2017.1349231.

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Poojitha M, Saravanakumar A S, and Satyanarayana S V. "Gastroprotective effect of leaves of Breyniavitis-Idaea." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 2519–24. http://dx.doi.org/10.26452/ijrps.v11i2.2247.

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Due to the lure backs of synthetic drugs that are being used medical field has turned over to the traditional medicine which are devoid of side effects and major adverse effects. So that Herbal drugs were seen as probable replacements for the handling of PUD without showing side effects and equaling the treatment efficacy. The literature review on investigations of antiulcer activity of various plant drug, the present investigation was carried out to investigate the antiulcer potential, chemical constituents present in the methanol extract of traditional plant Breyniavitis-idaea. Gastric ulcer

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Satapathy, Trilochan, Kalpana Sen, Shailesh Sahu, et al. "Experimental animal models for gastric ulcer / peptic ulcer: An overview." Journal of Drug Delivery and Therapeutics 14, no. 1 (2024): 182–92. http://dx.doi.org/10.22270/jddt.v14i1.6258.

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In the present study we have discussed around sixteen different animal models used worldwide for the scientific research and new drug discovery. The main aim of the using experimental animal models in drug discovery is to establish and provide evidence for non-clinical 'proof-of-concept' for the safety, efficacy, and target of interest for specific drug molecules. Experimental preparations developed in one species for the purpose of studying phenomena occurring in another species. The use of experimental animal models serves to better understand the origins, pathology, and the overall nature o

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Kaur, Amandeep, Sunil Kumar, and Ramica Sharma. "Assessment of Anti-Ulcer Activity of Rheum emodii Rhizomes Extract." Indo Global Journal of Pharmaceutical Sciences 02, no. 03 (2012): 333–41. http://dx.doi.org/10.35652/igjps.2012.38.

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Purpose: The purpose of the present study was to assess the antioxidant and antiulcer potential of ethanolic extract of rhizomes of R. emodi on Pylorus ligation ulcers. Materials and methods: Variable doses of 50 mg/kg and 100 mg/kg of EERE were administered orally by gavage for evaluating their antioxidant and antiulcer effect on pyloric ligation-induced ulcer in rats. Results: Both doses (50 mg/kg/p.o. and 100 mg/kg/p.o.) was found to reduce the ulcer index along with the reduction in volume and total acidity, and an increase in the pH of gastric fluid in pylorus ligated rats. The increase i

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Uwaeme, Ugonma Florence, Chinyelu Clementina Osigwe, and Jude Efiom Okokon. "Antiulcer Activity of Justicia insularis Leaf Extract on Experimentally-Induced Ulcers in Rats." Asian Journal of Biochemistry, Genetics and Molecular Biology 17, no. 4 (2025): 49–57. https://doi.org/10.9734/ajbgmb/2025/v17i4457.

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Peptic ulcer disease (PUD) is a significant gastrointestinal disorder that affects millions of people worldwide, imposing substantial burden on individuals, healthcare systems and economies. The available treatment options are not devoid of attendant sequalae. The search for less toxic, more effective and cheaper alternatives has continued to be areas of active research. The use of plants in the treatment of ulcer is one of such alternatives. Justicia insularis (Family-Acanthaceae) is a vegetable commonly used indigenously among southern people of Nigeria especially among the Ibibios of the So

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Pal, Saroj K., Pulok K. Mukherjee, and B. P. Saha. "Studies on the antiulcer activity ofMoringa oleifera leaf extract on gastric ulcer models in rats." Phytotherapy Research 9, no. 6 (1995): 463–65. http://dx.doi.org/10.1002/ptr.2650090618.

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