Relevant bibliographies by topics / Antiviral agents industry

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Academic literature on the topic 'Antiviral agents industry'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Antiviral agents industry"

1

Raut, Jay Kant. "Mushroom: a potent source of natural antiviral drugs." Applied Science and Technology Annals 1, no. 1 (June 30, 2020): 81–91. http://dx.doi.org/10.3126/asta.v1i1.30277.

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Emerging viral infections such as the zika virus, dengue virus, ebola virus, corona virus are afflicting millions of human populations worldwide. Therefore, the development of new treatments against emerging infectious diseases has become an urgent task. The availability of commercially viable, safe, and effective antiviral drugs still remains a big challenge. Mushrooms are considered as an untapped reservoir of several novel compounds of great value in industry and medicine. Although exploration, and exploitation of the therapeutic importance of fungal metabolites has started early with the discovery of penicillin, mushrooms’s pharmacological potential has much less been investigated. This article briefly reviews the antiviral potentials of mushrooms to combat deadly disease outbreaks caused by emerging and re-emerging viruses. Altogether 69 mushroom species with potent antiviral agents and mode of action against prominent viruses such as human immunodeficiency virus, influenza, herpes simplex virus, hepatitis B and C viruses, corona viruses etc. are listed in this study. Further studies are encouraged to discover more novel potent antiviral agents or evaluate already known compounds from those mushrooms with clinical trials.
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2

Hiscox, Julian A., Saye H. Khoo, James P. Stewart, and Andrew Owen. "Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?" Journal of Antimicrobial Chemotherapy 76, no. 9 (June 18, 2021): 2230–33. http://dx.doi.org/10.1093/jac/dkab189.

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Abstract This article provides a brief overview of drug resistance to antiviral therapy as well as known and emergent variability in key SARS-CoV-2 viral sequences. The purpose is to stimulate deliberation about the need to consider drug resistance prior to widespread roll-out of antivirals for SARS-CoV-2. Many existing candidate agents have mechanisms of action involving drug targets likely to be critical for future drug development. Resistance emerged quickly with monotherapies deployed for other pulmonary viruses such as influenza virus, and in HIV mutations in key drug targets compromised efficacy of multiple drugs within a class. The potential for drug resistance in SARS-CoV-2 has not yet been rigorously debated or assessed, and we call for more academic and industry research on this potentially important future threat prior to widespread roll-out of monotherapies for COVID-19 treatment and prevention.
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3

Varijakzhan, Disha, Jiun-Yan Loh, Wai-Sum Yap, Khatijah Yusoff, Rabiha Seboussi, Swee-Hua Erin Lim, Kok-Song Lai, and Chou-Min Chong. "Bioactive Compounds from Marine Sponges: Fundamentals and Applications." Marine Drugs 19, no. 5 (April 27, 2021): 246. http://dx.doi.org/10.3390/md19050246.

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Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from Theonella swinhoei have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief discussion regarding the mode of action of these compounds on the targeted sites in various pathogens. The bioactivity of the compounds discussed in this review is focused mainly on compounds that have been identified between 2000 and 2020 and includes the novel compounds discovered from 2018 to 2021.
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4

Ena, A., C. Pintucci, C. Faraloni, and G. Torzillo. "An eco-compatible process for the depuration of wastewater from olive mill industry." Water Science and Technology 60, no. 4 (April 1, 2009): 1055–63. http://dx.doi.org/10.2166/wst.2009.461.

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Olive mill wastewater (OMW) is the by-product of olive oil industrial production. It is characterized by a dark brownish color and a strong odor and is considered one of the most polluted agricultural wastes. In this paper we briefly describe an innovative procedure for the depuration of olive mill wastewater. With this procedure it is also possible to recover valuable substances such as phenolic compounds which have important commercial applications: they can be used in the prevention of cardiovascular disease and as antiviral, antioxidant and antitumor agents. The proposed OMW treatment uses two different packed vegetable matrices which remove most of the pollutant substances by absorption. After filtration of OMW on the matrices the pollutant load of the waste is greatly reduced: the organic content (COD) is reduced more than 80% and the phenol compounds are completely removed.
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5

Chemaly, Roy F., Sunwen Chou, Hermann Einsele, Paul Griffiths, Robin Avery, Raymund R. Razonable, Kathleen M. Mullane, et al. "Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials." Clinical Infectious Diseases 68, no. 8 (August 22, 2018): 1420–26. http://dx.doi.org/10.1093/cid/ciy696.

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Abstract Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major complication in solid organ and hematopoietic cell transplant recipients. CMV infection may fail to respond to commercially available antiviral therapies, with or without demonstrating genotypic mutation(s) known to be associated with resistance to these therapies. This lack of response has been termed “resistant/refractory CMV” and is a key focus of clinical trials of some investigational antiviral agents. To provide consistent criteria for future clinical trials and outcomes research, the CMV Resistance Working Group of the CMV Drug Development Forum (consisting of scientists, clinicians, regulatory officials, and industry representatives from the United States, Canada, and Europe) has undertaken establishing standardized consensus definitions of “resistant” and “refractory” CMV. These definitions have emerged from the Working Group’s review of the available virologic and clinical literature and will be subject to reassessment and modification based on results of future studies.
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6

Vargas-Hernandez, Marcela, Israel Macias-Bobadilla, Ramon Gerardo Guevara-Gonzalez, Enrique Rico-Garcia, Rosalia Virginia Ocampo-Velazquez, Luciano Avila-Juarez, and Irineo Torres-Pacheco. "Nanoparticles as Potential Antivirals in Agriculture." Agriculture 10, no. 10 (September 30, 2020): 444. http://dx.doi.org/10.3390/agriculture10100444.

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Viruses are estimated to be responsible for approximately 50% of the emerging plant diseases, which are difficult to control, and in some cases, there is no cure. It is essential to develop therapy practices to strengthen the management of these diseases caused by viruses in economically important crops. Metal nanoparticles (MeNPs) possess diverse physicochemical properties that allow for them to have a wide range of applications in industry, including nanomedicine and nano-agriculture. Currently, there are reports of favorable effects of the use of nanoparticles, such as antibacterial, antifungal, and antiviral effects, in animals and plants. The potential antiviral property of MeNPs makes them a powerful option for controlling these histological agents. It is crucial to determine the dosage of NPs, the application intervals, their effect as a biostimulant, and the clarification of the mechanisms of action, which are not fully understood. Therefore, this review focuses on discussing the ability of metal nanoparticles and metal oxides to control viruses that affect agriculture through an exhaustive analysis of the characteristics of the particles and their interaction processes for a possibly beneficial effect on plants.
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7

Nayarisseri, Anuraj. "Most Promising Compounds for Treating COVID-19 and Recent Trends in Antimicrobial & Antifungal Agents." Current Topics in Medicinal Chemistry 20, no. 24 (November 2, 2020): 2119–25. http://dx.doi.org/10.2174/156802662023201001094634.

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Multidrug resistance in microbes poses a major health crisis and demands for the discovery of novel antimicrobial agents. The recent pandemic of SARS-CoV-2 has raised a public health emergency in almost all the countries of the world. Unlike viruses, a bacterium plays a significant role in various environmental issues such as bioremediation. Furthermore, biosurfactants produced by various bacterial species have an edge over traditionally produced chemical surfactants for its biodegradability, low toxicity and better interfacial activity with various applications in agriculture and industry. This special issue focuses on the global perspective of drug discovery for various antimicrobial, antiviral, and antifungal agents for infectious diseases. The issue also emphasizes the ongoing developments and the role of microbes in environmental remediation. We wish the articles published in this issue will enhance the current understanding in microbiology among the readers, and serve as the "seed of an idea" for drug development for ongoing COVID-19 pandemic.
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8

Cárdenas, Constanza, Fanny Guzmán, Marisela Carmona, Cristian Muñoz, Luis Nilo, Alvaro Labra, and Sergio H. Marshall. "Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon." Pathogens 9, no. 8 (July 23, 2020): 600. http://dx.doi.org/10.3390/pathogens9080600.

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Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectivity processes. The peptides were tested in fish cell lines in vitro, and four were selected for decreasing the viral load: peptide GIM182 for IPNV, and peptides GIM535, GIM538 and GIM539 for ISAV. In vivo tests with the IPNV GIM 182 peptide were carried out using Salmo salar fish, showing a significant decrease of viral load, and proving the safety of the peptide for fish. The results indicate that the use of peptides as antiviral agents in disease control might be a viable alternative to explore in aquaculture.
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9

Zaidi, Kamal Uddin, Ayesha S. Ali, Sharique A. Ali, and Ishrat Naaz. "Microbial Tyrosinases: Promising Enzymes for Pharmaceutical, Food Bioprocessing, and Environmental Industry." Biochemistry Research International 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/854687.

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Tyrosinase is a natural enzyme and is often purified to only a low degree and it is involved in a variety of functions which mainly catalyse theo-hydroxylation of monophenols into their correspondingo-diphenols and the oxidation ofo-diphenols too-quinones using molecular oxygen, which then polymerizes to form brown or black pigments. The synthesis ofo-diphenols is a potentially valuable catalytic ability and thus tyrosinase has attracted a lot of attention with respect to industrial applications. In environmental technology it is used for the detoxification of phenol-containing wastewaters and contaminated soils, as biosensors for phenol monitoring, and for the production of L-DOPA in pharmaceutical industries, and is also used in cosmetic and food industries as important catalytic enzyme. Melanin pigment synthesized by tyrosinase has found applications for protection against radiation cation exchangers, drug carriers, antioxidants, antiviral agents, or immunogen. The recombinantV. spinosumtryosinase protein can be used to produce tailor-made melanin and other polyphenolic materials using various phenols and catechols as starting materials. This review compiles the recent data on biochemical and molecular properties of microbial tyrosinases, underlining their importance in the industrial use of these enzymes. After that, their most promising applications in pharmaceutical, food processing, and environmental fields are presented.
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10

Xu, Zhichao, Meiyan Huang, Yongbo Xia, Peng Peng, Yun Zhang, Shumei Zheng, Xiaowei Wang, Chunyi Xue, and Yongchang Cao. "Emodin from Aloe Inhibits Porcine Reproductive and Respiratory Syndrome Virus via Toll-Like Receptor 3 Activation." Viruses 13, no. 7 (June 26, 2021): 1243. http://dx.doi.org/10.3390/v13071243.

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Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe reproductive failure in sows and respiratory diseases in growing and finishing pigs and results in great economic losses to the swine industry. Although vaccines are available, PRRSV remains a major threat to the pig farms. Thus, there is an urgent need to develop antiviral drugs to compensate for vaccines. In this study, we report that Aloe extract (Ae) can strongly inhibit PRRSV in Marc-145 cells and porcine alveolar macrophages lines (iPAMs) in vitro. Furthermore, we identified a novel anti-PRRSV molecule, Emodin, from Ae by high-performance liquid chromatography (HPLC). Emodin exerted its inhibitory effect through targeting the whole stages of PRRSV infectious cycle. Moreover, we also found that Emodin can inactivate PRRSV particles directly. Notably, we confirmed that Emodin was able to significantly induce Toll-like receptor 3 (TLR3) (p < 0.01), IFN-α (p < 0.05) and IFN-β expression in iPAMs, indicating that induction of antiviral agents via TLR3 activation by Emodin might contribute to its anti-PRRSV effect. These findings imply that the Emodin from Aloe could hamper the proliferation of PRRSV in vitro and might constitute a new approach for treating PRRSV infection.
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Books on the topic "Antiviral agents industry"

1

Elder, Melissa. The market for prescription antiviral drugs. Norwalk, CT: Business Communications Co., 2002.

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2

New trends in antivirals: Highlighting antisense oligonucleotides in medicine and agriculture. Norwalk, CT: Business Communications Co., 1992.

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3

Hayes, Teresa L., Rebecca L. Friedman, and Michael B. Richardson. Biocides. Cleveland: Freedonia Group, 2000.

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(Firm), Find/SVP, ed. The market for antiviral therapeutics and vaccines. New York: FIND/SVP, 1996.

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5

Frost & Sullivan., ed. European antiviral drug and vaccine markets: New products brighten market outlook. Mountain View, Calif: Frost & Sullivan, 1994.

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6

L, Hayes Teresa, Franklin Jennifer Leslie 1946-, and Freedonia Group, eds. Biocides. Cleveland, OH: Freedonia Group, Inc., 1998.

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7

L, Hayes Teresa, Franklin Jennifer Leslie 1946-, and Freedonia Group, eds. Biocides / project director, Teresa L. Hayes; research analyst, Jennifer L. Franklin.rosalinda. Cleveland, Ohio: Freedonia Group, 1996.

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8

Specialists in Business Information, inc., ed. SBI market profile. New York: Specialists in Business Information, 1996.

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