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Journal articles on the topic 'Antiviral agents industry'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Dildora, Makhmudjonovna Ibragimova, Tokhirovna Farmanova Nodira, and Davronbekovna Kuranbaeva Maftuna. "Tanning Agents of Herb Lofanta Anis (Lophanthus Anisatus Benth.)." International Journal of Current Science Research and Review 06, no. 05 (2023): 2786–89. https://doi.org/10.5281/zenodo.7908638.

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<strong>ANNOTATION: </strong>The article is devoted to the tanning agents of herb Lofanta anis (lophanthus anisatus benth.) which is used for colds, respiratory and skin diseases, as an anti–inflammatory, antiviral, antimicrobial and expectorant. The medicinal plant raw material preparation Lophant aniseed–Lophanthus anisatus Benth, which has high effectiveness and low side effects on human health, based on the medicinal plants in the pharmaceutical industry of Uzbekistan.

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Raut, Jay Kant. "Mushroom: a potent source of natural antiviral drugs." Applied Science and Technology Annals 1, no. 1 (2020): 81–91. http://dx.doi.org/10.3126/asta.v1i1.30277.

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Emerging viral infections such as the zika virus, dengue virus, ebola virus, corona virus are afflicting millions of human populations worldwide. Therefore, the development of new treatments against emerging infectious diseases has become an urgent task. The availability of commercially viable, safe, and effective antiviral drugs still remains a big challenge. Mushrooms are considered as an untapped reservoir of several novel compounds of great value in industry and medicine. Although exploration, and exploitation of the therapeutic importance of fungal metabolites has started early with the d

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Sun, Yiwei, Liyan Wang, Keke Ma, et al. "Antiviral Activity of 1-Deoxynojirimycin Extracts of Mulberry Leaves Against Porcine Epidemic Diarrhea Virus." Animals 15, no. 9 (2025): 1207. https://doi.org/10.3390/ani15091207.

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Porcine epidemic diarrhea virus (PEDV), a highly infectious alphacoronavirus, has resulted in substantial economic losses within the global swine industry. Existing vaccines and therapeutic agents have proven inadequate in effectively preventing and controlling PEDV. Natural compounds offer distinct advantages in antiviral research due to their abundant availability, diverse biological activities, and low toxicity. In this study, the antiviral properties of the naturally occurring alkaloid 1-deoxynojirimycin (DNJ) against PEDV were examined. The CC50 of DNJ was determined to be 912.5 μM throug

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Hiscox, Julian A., Saye H. Khoo, James P. Stewart, and Andrew Owen. "Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?" Journal of Antimicrobial Chemotherapy 76, no. 9 (2021): 2230–33. http://dx.doi.org/10.1093/jac/dkab189.

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Abstract This article provides a brief overview of drug resistance to antiviral therapy as well as known and emergent variability in key SARS-CoV-2 viral sequences. The purpose is to stimulate deliberation about the need to consider drug resistance prior to widespread roll-out of antivirals for SARS-CoV-2. Many existing candidate agents have mechanisms of action involving drug targets likely to be critical for future drug development. Resistance emerged quickly with monotherapies deployed for other pulmonary viruses such as influenza virus, and in HIV mutations in key drug targets compromised

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Varijakzhan, Disha, Jiun-Yan Loh, Wai-Sum Yap, et al. "Bioactive Compounds from Marine Sponges: Fundamentals and Applications." Marine Drugs 19, no. 5 (2021): 246. http://dx.doi.org/10.3390/md19050246.

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Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from Theonella swinhoei have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have

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Chemaly, Roy F., Sunwen Chou, Hermann Einsele, et al. "Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials." Clinical Infectious Diseases 68, no. 8 (2018): 1420–26. http://dx.doi.org/10.1093/cid/ciy696.

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Abstract Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major complication in solid organ and hematopoietic cell transplant recipients. CMV infection may fail to respond to commercially available antiviral therapies, with or without demonstrating genotypic mutation(s) known to be associated with resistance to these therapies. This lack of response has been termed “resistant/refractory CMV” and is a key focus of clinical trials of some investigational antiviral agents. To provide consistent criteria for future clinical trials and outcomes research, the CMV

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Su, Guanming, Xiaoqun Yang, Qisheng Lin та ін. "Fangchinoline Inhibits African Swine Fever Virus Replication by Suppressing the AKT/mTOR/NF-κB Signaling Pathway in Porcine Alveolar Macrophages". International Journal of Molecular Sciences 25, № 13 (2024): 7178. http://dx.doi.org/10.3390/ijms25137178.

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African swine fever (ASF), caused by the African swine fever virus (ASFV), is one of the most important infectious diseases that cause high morbidity and mortality in pigs and substantial economic losses to the pork industry of affected countries due to the lack of effective vaccines. The need to develop alternative robust antiviral countermeasures, especially anti-ASFV agents, is of the utmost urgency. This study shows that fangchinoline (FAN), a bisbenzylisoquinoline alkaloid found in the roots of Stephania tetrandra of the family Menispermaceae, significantly inhibits ASFV replication in po

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Ena, A., C. Pintucci, C. Faraloni, and G. Torzillo. "An eco-compatible process for the depuration of wastewater from olive mill industry." Water Science and Technology 60, no. 4 (2009): 1055–63. http://dx.doi.org/10.2166/wst.2009.461.

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Olive mill wastewater (OMW) is the by-product of olive oil industrial production. It is characterized by a dark brownish color and a strong odor and is considered one of the most polluted agricultural wastes. In this paper we briefly describe an innovative procedure for the depuration of olive mill wastewater. With this procedure it is also possible to recover valuable substances such as phenolic compounds which have important commercial applications: they can be used in the prevention of cardiovascular disease and as antiviral, antioxidant and antitumor agents. The proposed OMW treatment uses

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Nill, Syed Atir Raza Shirazi, Sawera Kanwal, Junaid Asghar, Hamza Naveed, and Sarah khaleel. "RECENT ADVANCES IN MACHINE LEARNING MODELS FOR ANTIVIRAL PEPTIDE PREDICTION." VAWKUM Transactions on Computer Sciences 13, no. 1 (2025): 68–81. https://doi.org/10.21015/vtcs.v13i1.2047.

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Viral diseases are widespread and their impact is expressed in millions of cases of infection and mortality around the world, chronic viral diseases include COVID-19, HIV, and hepatitis. To prevent and treat these viral infections, novel agents, and antiviral peptides (AVPs) have been developed. Thus, identifying AVPs is crucial because these pieces of information are invaluable throughout the entire pharmaceutical industry and other sciences. This has been done experimentally and computationally but the need for better accurate and efficient predictors persists. This research also reviews cur

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Vargas-Hernandez, Marcela, Israel Macias-Bobadilla, Ramon Gerardo Guevara-Gonzalez, et al. "Nanoparticles as Potential Antivirals in Agriculture." Agriculture 10, no. 10 (2020): 444. http://dx.doi.org/10.3390/agriculture10100444.

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Viruses are estimated to be responsible for approximately 50% of the emerging plant diseases, which are difficult to control, and in some cases, there is no cure. It is essential to develop therapy practices to strengthen the management of these diseases caused by viruses in economically important crops. Metal nanoparticles (MeNPs) possess diverse physicochemical properties that allow for them to have a wide range of applications in industry, including nanomedicine and nano-agriculture. Currently, there are reports of favorable effects of the use of nanoparticles, such as antibacterial, antifu

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Gurunathan, Sangiliyandi, Pratheep Thangaraj, and Jin-Hoi Kim. "Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases." Foods 13, no. 1 (2023): 89. http://dx.doi.org/10.3390/foods13010089.

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequ

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Zayed, Mohamed F. "Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines." Chemistry 5, no. 4 (2023): 2566–87. http://dx.doi.org/10.3390/chemistry5040166.

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Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry. The system is of extensive importance due to its comprehensive array of biological activities. Quinoxaline derivatives have been used as anticancer, anticonvulsant, anti-inflammatory, antidiabetic, antioxidant, antibacterial, anti-TB, antimalarial, antiviral, anti-HIV, and many other uses. Variously substituted quinoxalines are significant therapeutic agents in the pharmaceutical industry. This review spotlights on the ch

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Rybalchenko, N. P., К. S. Naumenko, L. O. Artiukh, et al. "Antimicrobial and Antiviral Activity of Silver-Containing Nanocomposites Formed by 3D Printing Technology." Mikrobiolohichnyi Zhurnal 84, no. 3 (2022): 69–81. http://dx.doi.org/10.15407/microbiolj84.03.069.

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Silver nanoparticles have become the focus of numerous researchers to create efficient antimicrobial and antiviral agents due to their pronounced pharmacological effects, low toxicity to the human body and the environment, and high stability in extreme conditions. To create antimicrobial drugs with silver nanoparticles, matrices from polymers of both synthetic and natural origin are used. Biopolymer polylactide (PLA) is one of the most promising materials for 3D printing (additive production) due to its physicochemical and technological properties. The aim of the work was to study the antimicr

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Li, Pengfei, Shuaishuai Huang, Shuangyan Xiao, et al. "Antiviral Activities of Green Tea Components against Grouper Iridovirus Infection In Vitro and In Vivo." Viruses 14, no. 6 (2022): 1227. http://dx.doi.org/10.3390/v14061227.

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(1) Background: Singapore grouper iridovirus (SGIV) can cause extensive fish deaths. Therefore, developing treatments to combat virulent SGIV is of great economic importance to address this challenge to the grouper aquaculture industry. Green tea is an important medicinal and edible plant throughout the world. In this study, we evaluated the use of green tea components against SGIV infection. (2) Methods: The safe working concentrations of green tea components were identified by cell viability detection and light microscopy. Additionally, the antiviral activity of each green tea component agai

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Cárdenas, Constanza, Fanny Guzmán, Marisela Carmona, et al. "Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon." Pathogens 9, no. 8 (2020): 600. http://dx.doi.org/10.3390/pathogens9080600.

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Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectiv

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Chen, Zheng, Jinfeng Chen, Xiaodong Wei, et al. "Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro." Viruses 13, no. 12 (2021): 2527. http://dx.doi.org/10.3390/v13122527.

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Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and high mortality, resulting in tremendous damages to the swine industry. Neither specific antiviral drugs nor effective vaccines are available, posing a high priority to screen antiviral drugs. The aim of this study is to investigate anti-PEDV effects of carbazole alkaloid derivatives. Eighteen carbazole derivatives (No.1 to No.18) were synthesized, and No.5, No.7, and No.18 were identified to markedly reduc

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Ke, Qiyun, Kaiqi Duan, Yan Cheng, Si Xu, Shaobo Xiao, and Liurong Fang. "Sanguinarine Exhibits Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus via Multisite Inhibition Mechanisms." Viruses 15, no. 3 (2023): 688. http://dx.doi.org/10.3390/v15030688.

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Porcine reproductive and respiratory syndrome virus (PRRSV), the etiological agent of PRRS, is prevalent worldwide, causing substantial and immense economic losses to the global swine industry. While current commercial vaccines fail to efficiently control PRRS, the development of safe and effective antiviral drugs against PRRSV is urgently required. Alkaloids are natural products with wide pharmacological and biological activities. Herein, sanguinarine, a benzophenanthridine alkaloid that occurs in many plants such as Macleaya cordata, was demonstrated as a potent antagonist of PRRSV. Sanguina

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Nayarisseri, Anuraj. "Most Promising Compounds for Treating COVID-19 and Recent Trends in Antimicrobial & Antifungal Agents." Current Topics in Medicinal Chemistry 20, no. 24 (2020): 2119–25. http://dx.doi.org/10.2174/156802662023201001094634.

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Multidrug resistance in microbes poses a major health crisis and demands for the discovery of novel antimicrobial agents. The recent pandemic of SARS-CoV-2 has raised a public health emergency in almost all the countries of the world. Unlike viruses, a bacterium plays a significant role in various environmental issues such as bioremediation. Furthermore, biosurfactants produced by various bacterial species have an edge over traditionally produced chemical surfactants for its biodegradability, low toxicity and better interfacial activity with various applications in agriculture and industry. Th

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Mazurkiewicz-Pisarek, Anna, Joanna Baran, and Tomasz Ciach. "Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use." International Journal of Molecular Sciences 24, no. 10 (2023): 9031. http://dx.doi.org/10.3390/ijms24109031.

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Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life forms. Here we discuss AMPs, which may become a promising substitute or adjuvant in pharmaceutical, biomedical, and cosmeceutical uses. Their pharmacological potential has been investigated intensively, especially as antibacterial and antifungal drugs and as promising antiviral and anticancer agents. AMPs exhibit many properties, and some of these have attracted the attention of the cosmetic industry. AMPs are being developed as novel antibiotics to combat multidrug-resistant pathogens and as potential

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Xu, Zhichao, Meiyan Huang, Yongbo Xia, et al. "Emodin from Aloe Inhibits Porcine Reproductive and Respiratory Syndrome Virus via Toll-Like Receptor 3 Activation." Viruses 13, no. 7 (2021): 1243. http://dx.doi.org/10.3390/v13071243.

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Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe reproductive failure in sows and respiratory diseases in growing and finishing pigs and results in great economic losses to the swine industry. Although vaccines are available, PRRSV remains a major threat to the pig farms. Thus, there is an urgent need to develop antiviral drugs to compensate for vaccines. In this study, we report that Aloe extract (Ae) can strongly inhibit PRRSV in Marc-145 cells and porcine alveolar macrophages lines (iPAMs) in vitro. Furthermore, we identified a novel anti-PRRSV molecule, Emodin, fro

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Zaidi, Kamal Uddin, Ayesha S. Ali, Sharique A. Ali, and Ishrat Naaz. "Microbial Tyrosinases: Promising Enzymes for Pharmaceutical, Food Bioprocessing, and Environmental Industry." Biochemistry Research International 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/854687.

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Tyrosinase is a natural enzyme and is often purified to only a low degree and it is involved in a variety of functions which mainly catalyse theo-hydroxylation of monophenols into their correspondingo-diphenols and the oxidation ofo-diphenols too-quinones using molecular oxygen, which then polymerizes to form brown or black pigments. The synthesis ofo-diphenols is a potentially valuable catalytic ability and thus tyrosinase has attracted a lot of attention with respect to industrial applications. In environmental technology it is used for the detoxification of phenol-containing wastewaters and

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Zhang, Hang, Huiyang Sha, Limei Qin, et al. "Research Progress in Porcine Reproductive and Respiratory Syndrome Virus–Host Protein Interactions." Animals 12, no. 11 (2022): 1381. http://dx.doi.org/10.3390/ani12111381.

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Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), which has been regarded as a persistent challenge for the pig industry in many countries. PRRSV is internalized into host cells by the interaction between PRRSV proteins and cellular receptors. When the virus invades the cells, the host antiviral immune system is quickly activated to suppress the replication of the viruses. To retain fitness and host adaptation, various viruses have evolved multiple elegant strategies to manipulate the host

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Kamble, Nitin, Vishwanatha R. A. P. Reddy, Ben Jackson, et al. "Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro." Viruses 15, no. 8 (2023): 1652. http://dx.doi.org/10.3390/v15081652.

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Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control. Cholesterol 25-hydroxylase (CH25H), a gene that encodes an enzyme that catalyses cholesterol to 25-hydroxycholesterol (25-HC), is an interferon-stimulating gene (ISG) known to exert antiviral activities. Other oxysterols, such as 27-hydroxycholesterols (27-HC), have also been shown to exert antiviral activities, and 27-HC is synthesised by the

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Azman, Adzzie-Shazleen, Christina-Injan Mawang, and Sazaly Abubakar. "Bacterial Pigments: The Bioactivities and as an Alternative for Therapeutic Applications." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301240.

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Synthetic pigments have been widely used in various applications since the 1980s. However, the hyperallergenicity or carcinogenicity effects of synthetic dyes have led to the increased research on natural pigments. Among the natural resources, bacterial pigments are a good alternative to synthetic pigments because of their significant properties. Bacterial pigments are also one of the emerging fields of research since it offers promising opportunities for different applications. Besides its use as safe coloring agents in the cosmetic and food industry, bacterial pigments also possess biologica

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DEMCHENKO, V. L., S. V. RIABOV, S. M. KOBYLINSKYI, et al. "Silver-containing nanomaterials: preparation, morphology, antimicrobial and antiviral activity." Polymer journal 45, no. 1 (2023): 56–68. http://dx.doi.org/10.15407/polymerj.45.01.056.

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Infectious diseases caused by viruses and microorganisms continue to be one of the biggest health problems worldwide, despite the rapid progress in the creation of drugs and the development of pharmaceutical technologies. The risk of complications and the spread of infections in society remains high. Scientific research and the fight against viral infections, in particular with a large group of respiratory diseases caused by viruses, such as influenza viruses, parainfluenza viruses, respiratory sensitivities, adenoviruses, rhinoviruses, coronaviruses, etc., occupy an important place in modern

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Nazir, Iqra. "Evaluation of In Ovo Antiviral Activities of Medicinal Flowers against Newcastle Disease Virus and Avian Influenza Virus." International Journal of Agriculture and Biology 26, no. 01 (2021): 185–92. http://dx.doi.org/10.17957/ijab/15.1823.

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In Pakistan, the poultry industry is one of the rapidly growing industries. Due to lack of biosecurity measures, this is affected by some important infectious agents such as Avian Influenza virus (H9N2) and Newcastle disease virus (NDV) results in a huge economic loss. So, to control these losses discovery of new anti-viral drugs required to bring into line to fight against these infections. It is a general perception that the active components of medicinal plants have effective results against various infections like the influenza virus. The current therapeutic facilities need to be improved

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Yin, Jinhua, Jialu Zhang, Yi Liu, Cong Duan, and Jiufeng Wang. "Bergamottin Inhibits Bovine Viral Diarrhea Virus Replication by Suppressing ROS-Mediated Endoplasmic Reticulum Stress and Apoptosis." Viruses 16, no. 8 (2024): 1287. http://dx.doi.org/10.3390/v16081287.

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Bovine viral diarrhea virus (BVDV) is one of the most important etiological agents that causes serious economic losses to the global livestock industry. Vaccines usually provide limited efficacy against BVDV due to the emergence of mutant strains. Therefore, developing novel strategies to combat BVDV infection is urgently needed. Bergamottin (Berg), a natural furanocoumarin compound, possesses various pharmaceutical bioactivities, but its effect on BVDV infection remains unknown. The present study aimed to investigate the antiviral effect and underlying mechanism of Berg against BVDV infection

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Bayramov, M. D., O. V. Nesterova, D. A. Dobrokhotov, S. P. Zavadskiy, and A. K. Zhevlakova. "Comparative content analysis of biologically active substances in citrus peel." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 18–24. http://dx.doi.org/10.33920/med-13-2306-02.

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The analysis of the documents of the Ministry of Health of the Russian Federation shows that in 2021, there were 38.44 million cases of acute upper respiratory infections of multiple and unspecified localization, which accounted for 75.8% of all infectious and parasitic diseases. Researchers are interested in the creation of drugs for the treatment and prevention of acute respiratory viral infections using extracts and essential oils of plants with antiviral activity. Among the significant number of essential oil plants with potential antibacterial and antiviral effects, plants of the citrus f

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Li, Lian-Feng, Jiahui Yu, Yongfeng Li, et al. "Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity." Journal of Virology 90, no. 9 (2016): 4412–26. http://dx.doi.org/10.1128/jvi.02718-15.

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ABSTRACTMany viruses trigger the type I interferon (IFN) pathway upon infection, resulting in the transcription of hundreds of interferon-stimulated genes (ISGs), which define the antiviral state of the host. Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious viral disease endangering the pig industry in many countries. However, anti-CSFV ISGs are poorly documented. Here we screened 20 ISGs that are commonly induced by type I IFNs against CSFV in lentivirus-delivered cell lines, resulting in the identification of guanylate-binding prot

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Ahmad, Khurshid, Mohd Kalim A. Khan, Mohammad Hassan Baig, Mohd Imran, and Girish Kumar Gupta. "Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives." Anti-Cancer Agents in Medicinal Chemistry 18, no. 1 (2018): 46–56. http://dx.doi.org/10.2174/1871520616666161221112042.

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Background: Cancer has gradually become one of the leading causes of death worldwide. The incidence of cancer among the population has increased alarmingly over the last two decades, primarily due to an increasing population of immune-compromised patients and the continuing rise in anti-cancer drug resistance. Azole found privileged structure in medicinal chemistry and pharmaceutical industry and also found to be showing antioxidant; antimicrobial, anthelmintic, anticancer, antiviral, anti-parasitic, anti-inflammatory, anti-HIV, and antihypertensive activities. Objective: In this review, we hi

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Song, Xu, Zhongqiong Yin, Xinghong Zhao, et al. "Antiviral activity of sulfated Chuanmingshen violaceum polysaccharide against Newcastle disease virus." Journal of General Virology 94, no. 10 (2013): 2164–74. http://dx.doi.org/10.1099/vir.0.054270-0.

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Newcastle disease virus (NDV) is a member of Paramyxovirinae subfamily and can infect most species of birds causing severe economic losses. The current control measure is vaccination, but infections cannot be completely prevented. It remains a constant threat to the poultry industry and new control measures are urgently needed. This study demonstrates that sulfated Chuanmingshen violaceum polysaccharides (sCVPSs) were potent inhibitors of NDV, with 50 % inhibitory concentrations (IC50) ranging from 62.55 to 76.31 µg ml−1 in Baby hamster kidney fibroblasts clone 21 (BHK-21) and from 101.57 to 1

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Aksoy, Esra, Nilgün Güler, İbrahim Sözdutmaz, Serkan Kökkaya, Engin Berber, and Ayşe Gençay Göksu. "In Vitro Antiviral Potential of Cucurbitaceae Ecballium elaterium and Its Extract Containing Protease Inhibitors against Bovine Rotavirus." Microbiology Research 14, no. 4 (2023): 2079–89. http://dx.doi.org/10.3390/microbiolres14040140.

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Bovine rotaviruses (BRVs) are significant causative agents of severe diarrhea in newborn calves, resulting in substantial economic losses in the livestock industry. Inhibition of bovine rotavirus using extracts prepared from a Cucurbitaceae plant, which contains trypsin protease inhibitors, might offer a potential anti-rotaviral effect in vitro. Ecballium elaterium (E. elaterium) belongs to the Cucurbitaceae family, indigenous to the Mediterranean, contains E. elaterium trypsin isoinhibitors (EETIso), and has been used in traditional medicine. This study aimed to evaluate the in vitro efficacy

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Chbel, Asmaa, Aurelio Serrano Delgado, Abdelaziz Soukri, and Khalfi Bouchra El. "Marine biomolecules: a promising approach in therapy and biotechnology." European Journal of Biological Research 11, no. 1 (2021): 122–33. https://doi.org/10.5281/zenodo.4384158.

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The marine environment is characterized by a wide diversity of microorganisms among which marine bacteria. To insure their survival in hostile conditions where they face high competition with pathogenic microorganisms, they produce various kinds of bioactive molecules within biofilms with unique structural and functional features. As example: marine peptides which provide a broad spectrum of antimicrobial, antitumoral, antiviral and anti-inflammatory activities, in addition to marine exopolysaccharides showing antifouling and antifungal activities, immunomodulatory properties, emulsion stabili

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Bejenaru, Ludovic Everard, Antonia Radu, Adina-Elena Segneanu, et al. "Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications." Plants 13, no. 15 (2024): 2133. http://dx.doi.org/10.3390/plants13152133.

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This review investigates innovative strategies for upcycling agricultural residues into valuable pharmaceutical compounds. The improper disposal of agricultural residues contributes to significant environmental issues, including increased greenhouse gas emissions and ecosystem degradation. Upcycling offers a sustainable solution, transforming these residues into high-value bioproducts (antioxidants, antitumor agents, antidiabetic compounds, anti-inflammatory agents, and antiviral drugs). Nanotechnology and microbial biotechnology have a crucial role in enhancing bioavailability and targeted de

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Astray, Gonzalo, Patricia Gullón, Beatriz Gullón, Paulo E. S. Munekata, and José M. Lorenzo. "Humulus lupulus L. as a Natural Source of Functional Biomolecules." Applied Sciences 10, no. 15 (2020): 5074. http://dx.doi.org/10.3390/app10155074.

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Hops (Humulus lupulus L.) are used traditionally in the brewing industry to confer bitterness, aroma, and flavor to beer. However, in recent years, it has been reported that female inflorescences contain a huge variety of bioactive compounds. Due to the growing interest of the consumers by natural ingredients, intense research has been carried out in the last years to find new sources of functional molecules. This review collects the works about the bioactive potential of hops with applications in the food, pharmaceutical, or cosmetic industries. Moreover, an overview of the main extraction te

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T, Kilic. "Therapeutic Properties of Lactic Acid Bacteria." Open Access Journal of Microbiology & Biotechnology 9, no. 2 (2024): 1–4. http://dx.doi.org/10.23880/oajmb-16000287.

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Lactic acid bacteria (LAB) are considered a significant member of the human and animal intestinal microbiota due to their effects on host health, such as regulating the balance of the human and animal gastrointestinal microbiota. Thus, microecological balance can be maintained, and microbial infections can be prevented. In addition, LAB are used in bioprotective cultures to prevent spoilage and pathogenic microorganisms in the food industry. The therapeutic agents possessed by LAB include metabolites containing antibacterial, antifungal, antiviral, antioxidant, anticancer, immunomodulatory, an

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Rivero-Pino, Fernando, Maria Jose León, María del Carmen Millán-Linares, and la Paz Sergio Montserrat-de. "Antimicrobial plant-derived peptides obtained by enzymatic hydrolysis and fermentation as components to improve current food systems." TRENDS IN FOOD SCIENCE & TECHNOLOGY 135 (April 14, 2023): 32–42. https://doi.org/10.1016/j.tifs.2023.03.005.

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Background New challenges in our society are appearing following the emergence of antibiotic-resistant microorganisms and the concerns about the use of antibiotics. Furthermore, food spoilage due to microorganisms leads to food waste of around 1.3 billion tons each year. Bioactive peptides obtained from food proteins, released by enzymatic hydrolysis or fermentation, can be employed as a natural alternative to antibiotics and as preservative agents, due to their ability to inhibit the growth of several microorganisms. Plant protein use in the food industry is incr

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Gado, Ahmed R., Hany F. Ellakany, Ahmed R. Elbestawy, et al. "Herbal Medicine Additives as Powerful Agents to Control and Prevent Avian Influenza Virus in Poultry – A Review." Annals of Animal Science 19, no. 4 (2019): 905–35. http://dx.doi.org/10.2478/aoas-2019-0043.

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AbstractThe complicated epidemiological situation of avian influenza viruses (AIV) caused by continuous emergence of new subtypes with failure of eradication, monitoring and vaccination strategies opens the door to alternative solutions to save the status quo and prevent new disasters for the poultry industry. Using of synthetic antiviral drugs such as neuraminidase and hemagglutinin inhibitors has been limited due to development of drug resistance and expensive commercial application. One of the most promising alternatives is herbal products and botanicals. This review presents a comprehensiv

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Al-Adaileh, Rama, Ola Al-Madadheh, and Lena Almashaleh. "Marine sponge's biological activities: Their Biotechnological Uses." Journal of Basic and Applied Research in Biomedicine 8, no. 1 (2022): 26–34. http://dx.doi.org/10.51152/jbarbiomed.v8i1.219.

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The most of the time, marine sponges are an invertebrate species found in the tropics, subtropics, and temperate zones of the oceans and seas. They are acknowledged as being among the most important sources of bioactive chemicals, which are found in marine habitats and can then be recovered from those settings. These bioactive chemicals are found in marine environments and can then be extracted from those environments. It is common knowledge that the chemicals that are extracted from these sponges demonstrate a wide range of bioactivities, such as antibacterial activity, anticancer activity, a

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Onursal, Sağlam, Demiray* Gökçe, Güney Berrak, et al. "Single Dose, Two-way Crossover Bioequivalence Study of Favipiravir Tablet in Healthy Male Subjects." Journal of Pharmacy and Drug Development 2, no. 2 (2020): 1–9. https://doi.org/10.5281/zenodo.4361817.

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<strong>Abstract</strong> <strong>Background: </strong>As WHO expresses, coronavirus disease 2019 (COVID-19) is the infectious disease caused by the most recently discovered coronavirus. This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019. COVID- 19 is now a pandemic affecting many countries globally. Antiviral agents play fundamental role in Covid-19 treatment. Favipiravir is one of the favored agents and it still draws attention of generic drug industry which is constitutional for drug accessibility. <strong>Objective: </strong>The aim of this

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Keserű, György Miklós. "Vírusellenes terápiás lehetőségek COVID–19 fertőzés kezelésére." Scientia et Securitas 2, no. 1 (2021): 88–93. http://dx.doi.org/10.1556/112.2021.00003.

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Összefoglaló. A COVID–19-járvány egyre növekvő számú fertőzött betegének ellátása érdekében rövid időn belül szükség mutatkozott vírusellenes terápiás lehetőségekre. A gyors reagálás szempontját figyelembe véve erre a célra elsősorban más vírusok ellen már kifejlesztett vírusellenes szerek jöhetnek szóba. A magyar betegek ellátásbiztonsága szempontjából különösen fontos a hatóanyagok és gyógyszerkészítmények hazai gyártása. Ezt a cél tűzte ki a favipiravir, egy széles spektrumú antivirális hatóanyag hazai fejlesztése, amely sikeresen befejeződött, a gyógyszerkészítmény klinikai vizsgálata foly

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He, Wenfeng, Chen Li, Liangliang Dong, Guoqing Yang, and Huimin Liu. "Tandem Mass Tag-Based Quantitative Proteomic Analysis of ISG15 Knockout PK15 Cells in Pseudorabies Virus Infection." Genes 12, no. 10 (2021): 1557. http://dx.doi.org/10.3390/genes12101557.

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Pseudorabies virus (PRV) is recognized as one of the most important pathogens of swine and poses a serious threat to the swine industry worldwide. Available commercial vaccines fail to protect against the emergence of new PRV strains. Therefore, the new protein targets against PRV highlight the urgent need for uncovering the molecular determinants of host cellular proteins following PRV infection. Interferon-stimulated gene 15 (ISG15) demonstrates an outstanding antiviral response. However, the molecular mechanism of ISG15 that affects PRV replication is incompletely known. Here, we performed

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Wang, Zhonglei, Xian-qing Song, Wenjing Xu, Shizeng Lei, Hao Zhang, and Liyan Yang. "Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection." Nutrients 15, no. 18 (2023): 3885. http://dx.doi.org/10.3390/nu15183885.

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The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2. Several novel therapies have been approved and deployed in the last three years. However, their clinical application has revealed limitations due to the rapid emergence of viral variants. Therefore, the development of next-generation SARS-CoV-2 therapeutic agents with a high potency and safety profile remains a high priority for global health. Increasing awareness of the “back to nature” approach for improving human hea

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Haroon, Faisal, Umme Farwa, Maimoona Arif, et al. "Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications." Biomedicines 11, no. 10 (2023): 2686. http://dx.doi.org/10.3390/biomedicines11102686.

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A “building block” is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications. Anticancer, anti-Alzheimer’s, antibacterial, antiviral, antioxidant, and anti-inflammatory properties have been observed in PABA compounds, suggesting

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Jadhav, Sanjali, and Avinash Gangurde. "A Bird Eye View on Effervescent Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 1046–58. http://dx.doi.org/10.25258/ijddt.13.3.45.

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Effervescent drug delivery systems (EDDS) have gained significant attention in the pharmaceutical industry due to their unique characteristics and potential advantages over conventional dosage forms. This comprehensive review aims to provide an in-depth understanding of EDDS, including their formulation strategies, underlying mechanisms, and diverse applications in drug delivery. EDDS are effervescent dosage forms that release drugs upon water dissolution, leading toward carbon dioxide gas generation. The effervescence, resulting from the reaction between an acid and a base, facilitates rapid

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Nik Mohamad Nek Rahimi, Naqiuddin, Ikhsan Natrah, Jiun-Yan Loh, et al. "Phytocompounds as an Alternative Antimicrobial Approach in Aquaculture." Antibiotics 11, no. 4 (2022): 469. http://dx.doi.org/10.3390/antibiotics11040469.

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Despite culturing the fastest-growing animal in animal husbandry, fish farmers are often adversely economically affected by pathogenic disease outbreaks across the world. Although there are available solutions such as the application of antibiotics to mitigate this phenomenon, the excessive and injudicious use of antibiotics has brought with it major concerns to the community at large, mainly due to the rapid development of resistant bacteria. At present, the use of natural compounds such as phytocompounds that can be an alternative to antibiotics is being explored to address the issue of anti

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Ershov, Vadim, Natalia Tarasova, Evgeny Abkhalimov, Alexey Safonov, Vladimir Sorokin, and Boris Ershov. "Photochemical Synthesis of Silver Hydrosol Stabilized by Carbonate Ions and Study of Its Bactericidal Impact on Escherichia coli: Direct and Indirect Effects." International Journal of Molecular Sciences 23, no. 2 (2022): 949. http://dx.doi.org/10.3390/ijms23020949.

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The great attention paid to silver nanoparticles is largely related to their antibacterial and antiviral effects and their possible use as efficient biocidal agents. Silver nanoparticles are being widely introduced into various areas of life, including industry, medicine, and agriculture. This leads to their spreading and entering the environment, which generates the potential risk of toxic effect on humans and other biological organisms. Proposed paper describes the preparation of silver hydrosols containing spherical metal nanoparticles by photochemical reduction of Ag+ ions with oxalate ion

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Massa, Silvia, Riccardo Pagliarello, Francesca Paolini, and Aldo Venuti. "Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review." Journal of Clinical Medicine 11, no. 5 (2022): 1465. http://dx.doi.org/10.3390/jcm11051465.

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Human papillomavirus (HPV) still represents an important threat to health worldwide. Better therapy in terms of further improvement of outcomes and attenuation of related side-effects is desirable. The pharmaceutical industry has always targeted natural substances—phytochemicals in particular—to identify lead compounds to be clinically validated and industrially produced as antiviral and anticancer drugs. In the field of HPV, numerous naturally occurring bioactives and dietary phytochemicals have been investigated as potentially valuable in vitro and in vivo. Interference with several pathways

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Hillyer, Matthew B., Sunghyun Nam, and Brian D. Condon. "Intrafibrillar Dispersion of Cuprous Oxide (Cu2O) Nanoflowers within Cotton Cellulose Fabrics for Permanent Antibacterial, Antifungal and Antiviral Activity." Molecules 27, no. 22 (2022): 7706. http://dx.doi.org/10.3390/molecules27227706.

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With increasingly frequent highly infectious global pandemics, the textile industry has responded by developing commercial fabric products by incorporating antibacterial metal oxide nanoparticles, particularly copper oxide in cleaning products and personal care items including antimicrobial wipes, hospital gowns and masks. Current methods use a surface adsorption method to functionalize nanomaterials to fibers. However, this results in poor durability and decreased antimicrobial activity after consecutive launderings. In this study, cuprous oxide nanoparticles with nanoflower morphology (Cu2O

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Harris, Frederick, David A. Phoenix, and Sarah R. Dennison. "Antimicrobial Peptides from Frogs of the Glandirana Genus." Biologics 4, no. 4 (2024): 444–507. https://doi.org/10.3390/biologics4040027.

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Glandirana is a genus of frogs that includes G. rugosa, G. emeljanovi, G. minima, G. tientaiensis, G. susurra, G. nakamurai and G. reliquia. These frogs produce antimicrobial peptides (AMPs), which are endogenous antibiotics that possess antibacterial, antifungal, antiviral and anti-endotoxin activity and help keep the hosts free from infections. In these activities, microbial death is promoted by membranolytic mechanisms that are mediated by the cationic charge and amphiphilic α-helical structures of these peptides. In general, these peptides are selective for microbes, showing low levels of

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