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Journal articles on the topic 'Antiviral agents Ribosomes'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Brunelle, Marie-Noëlle, Léa Brakier-Gingras, and Guy Lemay. "Replacement of Murine Leukemia Virus Readthrough Mechanism by Human Immunodeficiency Virus Frameshift Allows Synthesis of Viral Proteins and Virus Replication." Journal of Virology 77, no. 5 (2003): 3345–50. http://dx.doi.org/10.1128/jvi.77.5.3345-3350.2003.

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ABSTRACT Retroviruses use unusual recoding strategies to synthesize the Gag-Pol polyprotein precursor of viral enzymes. In human immunodeficiency virus, ribosomes translating full-length viral RNA can shift back by 1 nucleotide at a specific site defined by the presence of both a slippery sequence and a downstream stimulatory element made of an extensive secondary structure. This so-called frameshift mechanism could become a target for the development of novel antiviral strategies. A different recoding strategy is used by other retroviruses, such as murine leukemia viruses, to synthesize the G

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2

Dahari, Harel, Ruy M. Ribeiro, Charles M. Rice, and Alan S. Perelson. "Mathematical Modeling of Subgenomic Hepatitis C Virus Replication in Huh-7 Cells." Journal of Virology 81, no. 2 (2006): 750–60. http://dx.doi.org/10.1128/jvi.01304-06.

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ABSTRACT Cell-based hepatitis C virus (HCV) replicon systems have provided a means for understanding HCV replication mechanisms and for testing new antiviral agents. We describe here a mathematical model of HCV replication that assumes that the translation of the HCV polyprotein occurs in the cytoplasm, that HCV RNA synthesis occurs in vesicular-membrane structures, and that the strategy of replication involves a double-stranded RNA intermediate. Our results shed light on the intracellular dynamics of subgenomic HCV RNA replication from transfection to steady state within Huh-7 cells. We predi

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3

Tumer, Nilgun E., Bijal A. Parikh, Ping Li, and Jonathan D. Dinman. "The Pokeweed Antiviral Protein Specifically Inhibits Ty1-Directed +1 Ribosomal Frameshifting and Retrotransposition in Saccharomyces cerevisiae." Journal of Virology 72, no. 2 (1998): 1036–42. http://dx.doi.org/10.1128/jvi.72.2.1036-1042.1998.

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ABSTRACT Programmed ribosomal frameshifting is a molecular mechanism that is used by many RNA viruses to produce Gag-Pol fusion proteins. The efficiency of these frameshift events determines the ratio of viral Gag to Gag-Pol proteins available for viral particle morphogenesis, and changes in ribosomal frameshift efficiencies can severely inhibit virus propagation. Since ribosomal frameshifting occurs during the elongation phase of protein translation, it is reasonable to hypothesize that agents that affect the different steps in this process may also have an impact on programmed ribosomal fram

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4

Dinman, Jonathan D., Maria J. Ruiz-Echevarria, and Stuart W. Peltz. "Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents." Trends in Biotechnology 16, no. 4 (1998): 190–96. http://dx.doi.org/10.1016/s0167-7799(97)01167-0.

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5

Gunaseelan, Saravanan, Kai Zhi Wong, Nyo Min, et al. "Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection." Science Translational Medicine 11, no. 516 (2019): eaar5759. http://dx.doi.org/10.1126/scitranslmed.aar5759.

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Human enterovirus A71 (HEVA71) causes hand, foot, and mouth disease (HFMD) in young children and is considered a major neurotropic pathogen but lacks effective antivirals. To identify potential therapeutic agents against HFMD, we screened a 502-compound flavonoid library for compounds targeting the HEVA71 internal ribosome entry site (IRES) that facilitates translation of the HEVA71 genome and is vital for the production of HEVA71 viral particles. We validated hits using cell viability and viral plaque assays and found that prunin was the most potent inhibitor of HEVA71. Downstream assays affi

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6

Zhou, Rong, Zhao Kun Liu, Ye Ni Zhang, Jack Ho Wong, Tzi Bun Ng, and Fang Liu. "Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms." Current Protein & Peptide Science 20, no. 3 (2019): 196–219. http://dx.doi.org/10.2174/1389203719666180613090710.

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For centuries, mushrooms have been widely used as traditional Chinese medicine in Asia. Apart from polysaccharides and some small-molecule components, such as flavones, polyphenols and terpenes, mushrooms produce a large number of pharmaceutically active proteins, which have become popular sources of natural antitumor, antimicrobial, immunoenhancing agents. These bioactive proteins include lectins, laccases, Ribosome Inactivating Proteins (RIPs), nucleases, and Fungal Immunomodulatory Proteins (FIPs). The review is to summarize the characterstics of structure and bioactivities involved in anti

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7

Romero-López, Cristina, Raquel Díaz-González, Alicia Barroso-delJesus, and Alfredo Berzal-Herranz. "Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule." Journal of General Virology 90, no. 7 (2009): 1659–69. http://dx.doi.org/10.1099/vir.0.008821-0.

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Hepatitis C virus (HCV) protein synthesis is mediated by a highly conserved internal ribosome entry site (IRES), mostly located at the 5′ untranslatable region (UTR) of the viral genome. The translation mechanism is different from that used by cellular cap-mRNAs, making IRESs an attractive target site for new antiviral drugs. The present work characterizes a chimeric RNA molecule (HH363-50) composed of two inhibitors: a hammerhead ribozyme targeting position 363 of the HCV genome and an aptamer directed towards the essential stem–loop structure in domain IV of the IRES region (which contains t

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8

Dmitriev, S. E., D. O. Vladimirov, and K. A. Lashkevich. "A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis." Biochemistry (Moscow) 85, no. 11 (2020): 1389–421. http://dx.doi.org/10.1134/s0006297920110097.

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Abstract Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs is known that specifically inhibit protein synthesis in eukaryotic cells. Many of them are well-studied ribosome-targeting antibiotics that block translocation, the peptidyl transferase center or the polypeptide exit tunnel, modulate the binding of translation machinery components to the ribosome, and induce miscoding, premature termination or stop codon readthrough. Such inhibitors are wi

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9

Vivanco, Jorge M., and Nilgun E. Tumer. "Translation Inhibition of Capped and Uncapped Viral RNAs Mediated by Ribosome-Inactivating Proteins." Phytopathology® 93, no. 5 (2003): 588–95. http://dx.doi.org/10.1094/phyto.2003.93.5.588.

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Ribosome-inactivating proteins (RIPs) are N-glycosidases that remove specific purine residues from the sarcin/ricin (S/R) loop of the large rRNA and arrest protein synthesis at the translocation step. In addition to their enzymatic activity, RIPs have been reputed to be potent antiviral agents against many plant, animal, and human viruses. We recently showed that pokeweed antiviral protein (PAP), an RIP from pokeweed, inhibits translation in cell extracts by binding to the cap structure of eukaryotic mRNA and viral RNAs and depurinating these RNAs at multiple sites downstream of the cap struct

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10

Leardkamolkarn, V., and W. Sirigulpanit. "Establishment of a Stable Cell Line Coexpressing Dengue Virus-2 and Green Fluorescent Protein for Screening of Antiviral Compounds." Journal of Biomolecular Screening 17, no. 3 (2011): 283–92. http://dx.doi.org/10.1177/1087057111426903.

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This study aimed to generate a stable cell line harboring subgenomic dengue virus replicon and a green fluorescent gene (DENV/GFP) for a cell-based model to screen anti-DENV compounds. The gene-encoding envelope protein of DENV-2 was deleted and then replaced with fragments of the GFP gene and a foot-and-mouth-disease virus 2A–derived cleavage site. The human cytomegalovirus immediate early and antisense hepatitis delta virus ribozyme sequences were added at the 5′- and 3′-ends. An internal ribosome entry site and neomycin resistance genes were placed upstream and next to the NS1 gene. The rec

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11

Ahn, Dae-Gyun, Gun Young Yoon, Sunhee Lee, et al. "A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses." Viruses 13, no. 8 (2021): 1639. http://dx.doi.org/10.3390/v13081639.

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Recent outbreaks of zoonotic coronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have caused tremendous casualties and great economic shock. Although some repurposed drugs have shown potential therapeutic efficacy in clinical trials, specific therapeutic agents targeting coronaviruses have not yet been developed. During coronavirus replication, a replicase gene cluster, including RNA-dependent RNA polymerase (RdRp), is alternatively translated via a process called -1 programmed ribosomal frameshift (−1

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12

Chittapragada, Maruthi, Sarah Roberts, and Young Wan Ham. "Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics." Perspectives in Medicinal Chemistry 3 (January 2009): PMC.S2381. http://dx.doi.org/10.4137/pmc.s2381.

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RNA is increasingly recognized for its significant functions in biological systems and has recently become an important molecular target for therapeutics development. Aminoglycosides, a large class of clinically significant antibiotics, exert their biological functions by binding to prokaryotic ribosomal RNA (rRNA) and interfering with protein translation, resulting in bacterial cell death. They are also known to bind to viral mRNAs such as HIV-1 RRE and TAR. Consequently, aminoglycosides are accepted as the single most important model in understanding the principles that govern small molecule

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13

Fernández-Miragall, Olga, and Encarnación Martínez-Salas. "In vivo footprint of a picornavirus internal ribosome entry site reveals differences in accessibility to specific RNA structural elements." Journal of General Virology 88, no. 11 (2007): 3053–62. http://dx.doi.org/10.1099/vir.0.83218-0.

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Internal ribosome entry site (IRES) elements were described in picornaviruses as an essential region of the viral RNA. Understanding of IRES function requires a detailed knowledge of each step involved in the internal initiation process, from RNA folding and IRES–protein interaction to ribosome recruitment. Thus, deciphering IRES accessibility to external agents due to RNA structural features, as well as RNA–protein protection within living cells, is of primary importance. In this study, two chemical reagents, dimethylsulfate (DMS) and aminomethylpsoralen, have been used to footprint the entir

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14

Giovannini, Catia, Francesca Fornari, Valentina Indio, et al. "Direct Antiviral Treatments for Hepatitis C Virus Have Off-Target Effects of Oncologic Relevance in Hepatocellular Carcinoma." Cancers 12, no. 9 (2020): 2674. http://dx.doi.org/10.3390/cancers12092674.

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Background and Aims: HCV eradication by direct-acting antiviral agents (DAAs) reduces de novo hepatocellular carcinoma (HCC) incidence in cirrhosis; however, contrasting evidence about beneficial or detrimental effects still exists in patients who have already developed HCC. Methods: we investigated whether sofosbuvir and daclatasvir modulate cell proliferation, invasion capability and gene expression (RNA-seq) in HCC-derived cell lines, hypothesizing possible off-target effects of these drugs. Results observed in HCC cell lines were validated in non-HCC cancer-derived cell lines and a prelimi

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15

Li, Lian-Feng, Jiahui Yu, Yongfeng Li, et al. "Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity." Journal of Virology 90, no. 9 (2016): 4412–26. http://dx.doi.org/10.1128/jvi.02718-15.

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ABSTRACTMany viruses trigger the type I interferon (IFN) pathway upon infection, resulting in the transcription of hundreds of interferon-stimulated genes (ISGs), which define the antiviral state of the host. Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious viral disease endangering the pig industry in many countries. However, anti-CSFV ISGs are poorly documented. Here we screened 20 ISGs that are commonly induced by type I IFNs against CSFV in lentivirus-delivered cell lines, resulting in the identification of guanylate-binding prot

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16

Ito, Takayoshi, Stanley M. Tahara, and Michael M. C. Lai. "The 3′-Untranslated Region of Hepatitis C Virus RNA Enhances Translation from an Internal Ribosomal Entry Site." Journal of Virology 72, no. 11 (1998): 8789–96. http://dx.doi.org/10.1128/jvi.72.11.8789-8796.1998.

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ABSTRACT Translation of most eukaryotic mRNAs and many viral RNAs is enhanced by their poly(A) tails. Hepatitis C virus (HCV) contains a positive-stranded RNA genome which does not have a poly(A) tail but has a stretch of 98 nucleotides (X region) at the 3′-untranslated region (UTR), which assumes a highly conserved stem-loop structure. This X region binds a polypyrimidine tract-binding protein (PTB), which also binds to the internal ribosome entry site (IRES) in HCV 5′-UTR. These RNA-protein interactions may regulate its translation. We generated a set of HCV RNAs differing only in their 3′-U

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17

Stone, Jeffrey K., Rene Rijnbrand, David A. Stein, et al. "A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus." Antimicrobial Agents and Chemotherapy 52, no. 6 (2008): 1970–81. http://dx.doi.org/10.1128/aac.00011-08.

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ABSTRACT Members of the genera Enterovirus and Rhinovirus (family Picornaviridae) cause a wide range of human diseases. An established vaccine is available only for poliovirus, and no effective therapy is available for the treatment of infections caused by any pathogenic picornavirus. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) are single-stranded DNA-like antisense agents that readily enter cells. A panel of PPMO was tested for their antiviral activities against various picornaviruses. PPMO targeting conserved internal ribosome entry site (IRES) sequence were highly acti

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18

King, Robert W., Marianne Zecher, Matthew W. Jeffries, Denise R. Carroll, Joseph M. Parisi, and Claudio Pasquinelli. "A Cell-Based Model of HCV-Negative-Strand RNA Replication Utilizing a Chimeric Hepatitis C Virus/Reporter RNA Template." Antiviral Chemistry and Chemotherapy 13, no. 6 (2002): 353–62. http://dx.doi.org/10.1177/095632020201300603.

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The inability of hepatitis C virus (HCV) to replicate in cell culture has hindered the discovery of antiviral agents against this virus. One of the biggest challenges has been to find a model that allows one to easily and accurately quantify the level of HCV RNA replication that is occurring inside the cell. In an attempt to solve this problem, we have created a plasmid pMJ050 that encodes a chimeric ‘HCV-like’ RNA that can act as a reporter for HCV RNA replication. This RNA consists of an antisense copy of the firefly luciferase sequence flanked by the 5′ and 3′ untranslated regions of the ne

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19

Yang, Shuang-Shuang, Jigui Wang, Zhaoda Li, Shangjin Cui, and Weiquan Liu. "The 5′ Untranslated Region of the Capsid Protein 2 Gene of Mink Enteritis Virus Is Essential for Its Expression." Journal of Virology 92, no. 18 (2018). http://dx.doi.org/10.1128/jvi.00787-18.

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ABSTRACTMink enteritis virus (MEV), as a parvovirus, is among the smallest of the animal DNA viruses. The limited genome leads to multifunctional sequences and complex gene expression regulation. Here, we show that the expression of viral capsid protein 2 (VP2) of MEV requires its 5′ untranslated regions (5′ UTR) which promote VP2 gene expression at both transcriptional and translational levels. The expression of VP2 was inhibited in several common eukaryotic expression vectors. Our data showed that the 5′ UTR of VP2 enhanced capsid gene transcription but not increased stability or promotes nu

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