Journal articles on the topic 'Antonio de Sosa (¿cantor?)'

Resumen: Los movimientos migratorios desde el campo a la ciudad llevaron al crítico Antonio Cornejo Polar a establecer la categoría literaria de sujeto migrante para dar cuenta de un proceso por el cual el sujeto va conformando un discurso descentrado, múltiple, que traduce una biculturalidad con elementos que, si bien son antagónicos, no se resuelven sintéticamente. A partir de aquí, se analiza la posibilidad de extender los alcances de dicha categoría a los sujetos de las diferentes migraciones en, desde y hacia Colombia, y que la literatura retoma como parte de un proceso que tiene proyección latinoamericana. Descriptores: Cornejo Polar, Antonio; Sujeto migrante; Nadanostra; Burgos Cantor, Roberto; Vallejo, Fernando; La virgen de los sicarios. Abstract: Antonio Cornejo Polar, by studying migratory movements from the countryside to the cities, proposes the concept of "migrant subject" as a literary category. This concept states the discursive process that becomes useful to explain the characteristics of the following subject constructions: multiplicity, descentralization, biculturality, these antagonistic elements do not mix synthetically. So, it's possible to extend the use of the category in order to study the subjects of different migration movements, in, from and to Colombia, in the literary discourse of Latinoamerica. Key words: Cornejo Polar, Antonio; Migrant subject; Nadanostra; Burgos Cantor, Roberto; Vallejo, Fernando; La virgen de los sicarios.

El presente artículo tiene como objetivo dar a conocer la evolución artística de Antonio Sosa desde finales de los años setenta hasta 1987. Tras un periodo inicial, el artista evoluciona desde la abstracción, imbuida de la práctica artística predominante en el momento, a un estilo cada vez más personal y acusado que toma elementos de su entorno más inmediato como generadores de un discurso que parte de la pregunta como punto para cuestionar las dudas existenciales más profundas. Este camino surge a través de un redimensionamiento del concepto de chamanismo como elemento clave en su práctica artística.

Antonio Sosa (Coria del Rio, Sevilla, 1952) es un extraño caso de artista primitivo y erudito, espiritual y científico, místico y laico, que busca desmantelar el conjunto de construcciones míticas tras las que el ser humano se ha encastillado para reprimir su inmensa soledad. Su obra exhala cierto carácter mágico y ritual que intriga al espectador; usa técnicas y materiales ancestrales que, en su momento, fueron considerados extra-artísticos; rompe con las coartadas formales y temáticas de las tradiciones académicas y modernas; y lanza una mirada arqueológica, antropológica, que anhela descubrir las claves ancestrales, primitivas y preclásicas del acto de creación, experimentando su validez en el mundo actual.

On behalf of our Papal Seminary community, I welcome Fr. Arturo Sosa, Superior General of the Society Jesus to our Home of Love. I also extend a warm welcome to Fr. Vernon D'Cunha (RA), Fr. Lisbert D'Souza (RA), Fr. George Pattery (POSA) and Fr. Juan Antonio Alves (Delegate For International Houses in Rome) to our great Home of Love. We put our hands together and welcome them warmly. As a Superior General, Fr. Arturo Sosa is the head of the Society of Jesus and for us in JDV, he is a Chancellor of JDV.  He is the 31st General of the Society of Jesus, elected on Oct 14, 2016. He comes from Venezuela. He is a person of vast experiences in the administration of the Society. He held several responsible posts and portfolios in the Society. He has a wealth of knowledge and wisdom. 

Abstract The Metastatic Breast Cancer Project (MBCproject) is an ongoing research study that directly engages patients (pts) through social media and advocacy groups, and empowers them to share their samples, clinical information, and experiences. The goal is to create a publicly available dataset of linked genomic, clinical, and pt-reported data to enable research. In collaboration with pts, advocates, and advocacy groups, a website (MBCproject.org) was developed that allows pts with metastatic breast cancer (MBC) anywhere in the US or Canada to register. From 10/20/15-6/1/21, 6100 patients with MBC registered for the MBCproject. Registered pts are sent an online consent form that asks for permission to obtain and analyze their medical records and samples. Consented pts are sent a saliva and/or blood kit and asked to mail back a saliva sample, which is used to extract germline DNA, and/or a blood sample, which is used to extract germline DNA and cell free DNA (cfDNA). We contact participants’ medical providers to obtain medical records and a portion of their stored tumor biopsies. 3456 pts receiving care at over 1700 different institutions have consented to share medical records and tumor/saliva/blood samples and to have genomic analysis performed. Whole exome sequencing (WES) is performed on tumor DNA, germline DNA, and cfDNA; transcriptome sequencing (RNA-seq) is performed on tumor RNA. Medical records and pt-reported data are abstracted to create a detailed clinical record for each pt. Table 1 highlights clinical data collection, biospecimen acquisition, and genomic data generation to date. Examples of clinicogenomic analyses are shown in Table 2. De-identified linked genomic, clinical, and pt-reported data is shared regularly via public databases (mbcproject.org, cBioPortal, dbGaP, NCI Genomic Data Commons). To date, this data has been cited in over 40 publications. Study updates are shared with participants regularly. The MBCproject continues to enroll new patients, generate additional data, and perform integrated clinical and genomic analyses with the goal of building a dataset that is representative of patients with MBC. We have partnered with over 30 non-profit breast cancer advocacy groups. We also have several community engagement efforts underway to more directly reach patients in underrepresented communities, including partnerships with faith-based organizations and colleges/universities, as well as targeted engagement with the African American community. In addition, in partnership with Latinx patients, advocates, and researchers, a Spanish-language version of the MBCproject was launched in June 2021. Partnering directly with pts rapidly enables thousands of pts to remotely share tumors, blood, saliva, and medical records to accelerate research. The resulting publicly shared clinically annotated dataset is a resource that allows researchers to identify patients with specific phenotypes, who have often been challenging to identify with traditional approaches. Clinical data collection, biospecimen acquisition, and genomic data generation:NumberConsent signed (US & CA)3456 ptsPatient-reported data collected (demographics, diagnosis details, receptor status, clinical experiences, pathology details, sites of metastasis, treatments with start and stop dates3456 ptsMedical record received from clinical institution1365 ptsSaliva sample received from pt2124 ptsBlood sample received from pt1114 ptsTumor samples received from clinical institution631 tumor samples from 398 ptsWES from germline complete505 germline samplesWES from tumor (primary and metastatic) samples complete429 tumor samplesRNA-seq from tumor (primary and metastatic) samples complete351 tumor samplesULP-WGS from cfDNA (taken in metastatic setting) complete953 blood samplesWES from circulating tumor DNA (taken in metastatic setting) complete144 blood samples CohortConsented (US & CA)Tumor WES completeTumor RNA-seq completePts diagnosed < 40 yrs of age114615292De novo MBC1207158109Late recurrence (>5 years after dx)9099141Long term survivors (MBC > 10yrs)163138Resistance to CDK4/6 inhibitors70914839NED at time of f/u survey4305445Triple Negative Breast Cancer3304632Patients with 2 or more tumor biopsies/cfDNA samples collected by the MBCproject29810882 Citation Format: Nikhil Wagle, Corrie Painter, Elana Anastasio, Mary McGillicuddy, Esha Jain, Tania G. Hernandez, Brett N. Tomson, Beena Thomas, Daniel Abravanel, Dewey Kim, Sara Balch, Alyssa L. Damon, Shahrayz Shah, Rafael Ramos, Delia Sosa, Ilan Small, Colleen Nguyen, Sarah Winnicki, Taylor Cusher, Parker Chastain, Michael Dunphy, Jorge Gomez Tejeda Zanudo, Netsanet Tsegai, Lauren Sterlin, Ulcha F. Ulysse, Imani Boykin, Oyin Alao, Todd R. Golub. The metastatic breast cancer project: Generating the clinical and genomic landscape of metastatic breast cancer through patient-partnered research [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT1-19-01.

AbstractThe objective of this work is analysing absolute interrogative sentences from the Spanish of San Antonio de Texas using three corpus featuring different levels of spontaneity (formal ad hoc, situational and conversational), and uttered by native speakers with superior studies. The choice of these corpus and their acoustic analyses have been performed according to the methodology established by the international project AMPER (Atlas Multimédia Prosodique de l’Espace Roman). Furthermore, we have undertaken the phonetic-phonological labelling of the boundary tones and of initial and nuclear pitch accents within the framework of the autosegmental-metrical model. This study has been carried out with the aim of contributing to the knowledge of Texan intonation, in order to make comparisons with other varieties of Spanish language as well as to include it in the international Atlas AMPER. We hypothesize that interrogatives from the informants considered follow the patterns described for Mexican interrogatives (Sosa, 1999; Ávila, 2003; Martín Butragueño, 2004, among others), taking into account the geographical location of San Antonio de Texas in relation to Mexico and the influence of Mexican immigration, which has a strong presence in San Antonio. Results provide evidence of such influence, particularly in the final ascent of the F0.

El artículo trata sobre las cuatro primeras carpetas de una edición de ocho promovidas por Luis María Venegas Lagüens, con la colaboración del pintor Ricardo Casstillo como director y coordinador, en 2010-14. Cada una contiene cuatro grabados en blanco y negro, excepto uno, el del director de la serie, concebido con dos tintas. Los artistas incluidos tienen una amplia trayectoria en la pintura sevillana más actual, hablamos de Magdalena Bachiller, Pedro Simón, Antonio Sosa, Ricardo Casstillo, Manuel Salinas, Ruth Morán, Curro González, Federico Guzmán, Daniel Bilbao, Félix de Cárdenas, Paco Cuadrado, Rafael Zapatero Javier Buzón, Matías Sánchez, Patricio Cabrera y Guillermo Pérez Villalta. Todos tuvieron libertad creativa para interpretar el paisaje andaluz, con lenguajes muy variados desde el naturalismo y el expresionismo hasta distintos tipos de simbolismos y la abstracción.

Este estudio presenta el elenco de datos biográficos hasta ahora más completos del sacerdote peruano Juan Pérez Bocanegra (ca. 1560-1570 - ca. 1634-1645). Se ofrecen las referencias de su trayectoria eclesiástica: estudios en el seminario de San Antonio Abad (Cusco), párroco de Belén (Cusco), párroco de San Pedro Apóstol de Andahuaylillas, cantor en la Catedral del Cusco y examinador oÀcial de la diócesis en quechua y aimara. Luego de pasar revista a las investigaciones precedentes y a los elementos biográficos de su Ritual formulario e instrucción de curas, de 1631, el autor aporta nuevos datos a partir de documentos inéditos del Cusco y Andahuaylillas

El siguiente trabajo tiene por objeto acercarse a las “mudanzas” que Antonio Gamoneda realizó en 2016 a partir de una serie de cantos del rey-poeta Nezahualcóyotl. El objetivo es poner en relación su actividad traductora con un ejercicio de reanimación del verbo. El poeta, a modo de chamán, rescata del lenguaje su energía o, dicho de otro modo, lo dota de nueva vida como si de un organismo se tratase. Afín a este proceso queda la idea de un despertar las propiedades musicales de la voz, primer paso del traductor antes de fijar su forma definitiva. El recorrido realizado será articulado por medio de aspectos o conceptos clave como lo cultual, el pharmakon, la naturaleza del cantor o la dialéctica entre dos modelos de lenguaje.

Es bien conocido el gusto de Franco por la copla y la canción española que contribuía a reforzar el sentimiento nacional español. Cada año, en la conmemoración del 18 de Julio, las estrellas del momento como Conchita Piquer, Juanita Reina, Lola Flores, Antonio Amaya, Antonio Molina etc. eran invitadas a interpretar las canciones favoritas del Generalísimo. Entre los intérpretes de la canción española, Manolo Escobar fue uno de los más populares en los años 60 y 70, a pesar del impacto de la música ye-ye y de los Beatles entre los jóvenes. Su repertorio evoluciona durante los sesenta de la canción andaluza hacia la canción española que canta a España y al pueblo español en general. Sus canciones se dirigen a un público sencillo, describiéndose a sí mismo como el cantor del pueblo. De 1963 a 1980 fue el protagonista de películas taquilleras, una cada año, y su abundante discografía muestra su creciente popularidad. ¿Cuál fue la clave de su éxito? ¿Existe algún vínculo entre su éxito y el apoyo del régimen? Finalmente, ¿de qué manera las canciones de Escobar han contribuido a crear un sentimiento de orgullo nacional?

RESUMENEl estudio histórico de la religiosidad islámica se ha encontrado tradicionalmente con el problema de la escasez de fuentes. Además, siempre se ha estudiado a partir de las fuentes islámicas, obviando las cristianas. Si es cierto que para la Edad Media las fuentes cristianas no ofrecen demasiada información y están además viciadas por su carácter polémico, también lo es que para la Edad Moderna, con el surgimiento de un tipo de literatura sobre el islam que está alejado de la tradición polémica, disponemos de un buen número de importantes fuentes cristianas que merecen ser tenidas en cuenta en cualquier análisis histórico de la religiosidad islámica. Es el caso especialmente de la Topographía e Historia general de Argel (1612), cuyas descripciones y observaciones resultan de una riqueza sin precedentes.PALABRAS CLAVE: Edad Moderna, cinco pilares del islam, religiosidad, España, Argel.ABSTRACTTraditionally, the historical study of Islamic religiosity has been faced with the problem of the scant amount of sources. Moreover, it has always been approached on the basis of Islamic sources, disregarding the Christian ones. If for the Middle Ages Christian sources do not present much information about the subject and this is tainted by its polemical character, for the Early Modern Age, with the emergence of a new kind of literature about Islam that does not belong to the polemical tradition, we have at our disposal a good number of sources of information. This is particularly thecase of the Topographía e Historia general de Argel (1612), with descriptions and observations of an unprecedented quality. 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Este traballo parte da recuperación dunha correspondencia do autor que revela a xénese, temáticas e estilo dos Ensayos poéticos en dialecto berciano de Antonio Fernández Morales. Analizamos a descuberta do galego do Bierzo a través da reflexión propiciada polo filólogo catalán Mariano Cubí e o propio encargo de escribir nesta lingua que asume Morales con entusiasmo. Indagamos nas fontes e na procura de temáticas para o libro. Emerxen así os costumes das xentes humildes que o poeta gusta describir, tanto na aldea como na vila, ao longo dun calendario tradicional peculiar, onde detectamos unha tendencia ao contraste e a utilización dun ton satírico e crítico sutil por veces, as máis proto-realista. A paisaxe natural e humana do Bierzo que retrata con vigor e detalle, fará do noso autor un cantor referente da identidade berciana á vez dun fito relevante para definir o movemento do Rexurdimento nos lindeiros da galeguidade. Concluímos coa definición doutro dos trazos do estilo do autor de carácter ideolóxico, o bercianismo, amén do seu interese por cantar a riqueza patrimonial do Bierzo.

Abstract Influenced by feminist perspectives on urban and architectural studies, this essay examines the relationship between premodern Muslim urbanism and gendered relations, an issue that has received little attention in Hispanic cultural studies to date. This discussion will center on two particular features of domestic architecture and city planning typical of sixteenth- and seventeenth-century Algiers: the location and nature of street-facing windows and the communicable rooftops. Focusing primarily on Christian writers such as Antonio de Sosa, Miguel de Cervantes, and Lope de Vega, Velasco explores how their accounts document the ways in which women in Algiers could find unexpected and illicit ways of turning the high windows and the communicable rooftops to their advantage. Despite the constraints presented by an urban design and domestic architecture intended to segregate the sexes and control behavior, women in early modern Algiers (many of whom were recent immigrants from Spain) found ways to utilize their built environment to observe and navigate the world around them, gain access to a public domain commonly reserved for men, and sustain networks with other women in ways that might bypass traditional spatial, social, and personal restrictions and limitations. Through female-only gatherings and other forms of camaraderie that made use of traditional Islamic urbanism, Muslim women in Algiers found ways to challenge long-standing dichotomies of male/female, public/private, interior/exterior, visible/hidden, and chaste/lustful.

Em “Águas do meu princípio”, presente em Pensatempos, livro lançado em 2005, o qual reúne textos de opinião de vária ordem, Mia Couto, ao relembrar a própria infância na Beira – sua terra natal e importante cidade portuária de Moçambique –, conduz os leitores através de uma ambiência que flerta, nostalgicamente, com uma atmosfera mítica. Nessas linhas, o escritor moçambicano convoca um importante legado cultural oriundo da Bahia: a célebre canção “É doce morrer no mar”, do cantor e compositor Dorival Caymmi, cujos versos são atribuídos a Jorge Amado e a elementos textuais que permeiam Mar Morto, romance publicado, em 1936, pelo escritor brasileiro mais reverenciado nas literaturas africanas de língua oficial portuguesa. A partir de tais reminiscências e, sobretudo, como exercício de crítica literária, poder-se-á estabelecer relações de contiguidade entre excertos de “Águas do meu princípio” e a estrutura interna que rege o núcleo de maior pulsão poética em O Último Voo do Flamingo, romance de 2000. Para tanto, as reflexões de Antonio Candido, Roland Barthes, Benjamin Abdala Junior, Pierre Bourdieu, entre outros, serão implicadas neste estudo a fim de demonstrarem os elos literários e musicais que ligam Brasil e Moçambique através dos séculos.

Lista de autores revista No. 24 Rosario Asián ChavesDoctora en EconomiaUniversidad de Sevilla – España rasian@us.es Ruth Yolanda Atilano VillegasEstudiante Maestria en historiaUniversidad de Guanajuato – Méxicoatilanovillegas@gmail.com Wilma Nury Blanco RuizMagister en Desarrollo Rural Universidad Pedagógica y Tecnologica de Colombia - Colombiavilmanury@gmail.com Francisca Cabeza VerdugoLicenciada en Ciencia del Trabajo Universidad de Sevilla – España fcabeza@hotmail.com Elvia Montes de Oca NavasDoctora en Estudios Latinoamericanos Grupo de investigación HISULA - UPTCelvia.montesdeoca@gmail.com Margareth DinizUniversidade Federal de Ouro Preto – Brasil dinizmargareth@yahoo.com. Consuelo Flecha García Doctora en Ciencias de la Educación Universidad de Sevilla - EspañaGrupo de investigación HISULA – UPTCcflecha@us.es Ana Guil Bozal Doctora en Psicologia Social Universidad de Sevilla - EspañaGrupo de investigación HISULA - UPTCanaguil@us.es Diana Crucelly González ReyDoctoranda en HistoriaCIESAS- Unidad Peninsular. Yucatán - México nanaplanta@historiaabierta.orgo José Rubens Lima JardilinoUniversidade Federal de Ouro Preto – BrasilGrupo de pesquisa HISULA – UPTC Grupo de pesquisa FOPROFI-UFOP jrjardilino@gmail.com Vicente Rodríguez Sosa Licenciado en Ciencias Ecomonicas y Empresariales Universidad de Sevilla – España vsosa@us.es Marianela Rosa Peña LoraMagister eb Ciencias de la Educaciòn Casa del Caribe – Santiago de Cubapeamarianela@gmail.com Morelia Pabón Patiño Doctora en Ciencias de la Educación Universidad Tecnológica de Colombia – Colombiamopabon@utp.edu.co Morelos Torres Aguilar Doctor en HistoriaUniversidad de Guanajuato – MéxicoGrupo de investigación HISULA – UPTCmorelostorres@gmail.com Celina de Jesús Trimiño VelásquezDoctora en Derechos Fundamentales Universidad Pedagógica y Tecnológica de Colombia - ColombiaGrupo de Investigación GIEPEG en Alianza con HISULA celinatrimino@gmail.com Antonio Jesús Yugueros GarcíaDoctor en Desarrollo y ciudadania Universidad Pablo de Olavide - Españaantyugue@hotmail.com

Abstract Neurofibromatosis type 1 (NF1) is a genetic disorder that affects the nervous system. It is caused by mutations in the NF1 gene. NF1 loss of function leads to elevated RAS signaling, which plays a crucial role in cell growth and proliferation. Due to the dysregulated RAS signaling, individuals with NF1 are prone to the development of neurofibromas. These neurofibromas are typically benign and called Plexiform Neurofibromas (PNFs), in some cases, they can transform into malignant peripheral nerve sheath tumors (MPNSTs). MPNSTs are highly aggressive and invasive cancers that contribute to a significant proportion of soft tissue sarcomas. The exact mechanisms behind this transformation are not fully understood, however it involves additional genetic mutations and alterations in cellular signaling pathways. With limited effective targeted therapies available, surgical removal remains the primary treatment option. However, due to tumor size and location, surgery may not always be feasible. The MEK inihibitor, selumetinib, has received approval for the treatment of PNFs, however some patients who were treated with selumetinib continued to develop MPNSTs suggesting that MEK inhibitors may have limitations in addressing MPNSTs. To target the RAS pathway and mitigate the effects of NF1 gene alterations, we aim to explore the therapeutic potential of two novel, potent and orally bioavailable small molecule inhibitors targeting SOS1 (BI 1701963) or KRAS (KRASmulti inhibitor BI 3706674), as alternative treatment options for MPNSTs. The KRASmulti inhibitor BI 3706674 binds non-covalently to the KRAS wild type allele as well as multiple KRAS mutant alleles in the GDP-bound state and thereby disrupts KRAS signaling. Therefore, we hypothesize that both inhibitors will work in NF1 models by reducing activated KRAS levels. In this study, a series of in vitro and in vivo experiments were conducted to evaluate the efficacy of BI 1701963 and BI 3706674 inhibitors, both individually and in combination. The studies were done in comparison to the MEK inhibitor selumetinib. In vitro analysis revealed a synergistic anti-proliferative effect when combining BI 1701963 and BI 3706674 inhibitors both in 2D and 3D growth conditions, which led to the downregulation of the RAS pathway, specifically the MAPK and PI3K signaling cascade, and an increase in apoptosis. The in vivo efficacy of either BI 1701963 or BI 3706674 inhibitor alone or in combination was tested in four different in vivo MPNST models. We observed significant tumor growth stabilization as well as tumor regression in all tested models in vivo. In-depth pathway modulation and pharmaco-dynamic studies are ongoing. In conclusion, this study highlights the combined effects of SOS1 (BI 1701963) and KRAS (BI 3706674) inhibition in MPNSTs. The combination therapy of these novel therapeutics may hold promise as a potential treatment strategy for patients with MPNSTs. Citation Format: Özlem Yüce Petronczki, Laura Pisarsky, Petra Lujza Szabó, Julia Brunmair, Antonia Geyer, Norbert Kraut, Darryl McConnell, Irene Waizenegger. Therapeutic potential of SOS1 and KRAS inhibitors in malignant peripheral nerve sheath tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4564.

Abstract Extracellular matrix (ECM) protein expression/deposition within and stiffening of the breast cancer (BC) microenvironment, facilitates disease progression and correlates with poor patient survival. However, the mechanisms by which ECM components control tumorigenic behaviors and responses to therapeutic intervention remain poorly understood. Fibronectin (FN) is a major ECM protein controlling multiple processes related to cancer metastasis. In this regard, we previously reported that DHPS-dependent hypusination of eIF5A1/2 is necessary for fibronectin-mediated BC metastasis and epithelial to mesenchymal transition (EMT). Here, we explored the clinical significance of an interactome generated using hypusination pathway components and markers of intratumoral heterogeneity. Solute carrier 3A2 (SLC3A2 or CD98hc) stood out as an indicator of poor overall survival among patients with basal-like BCs that express elevated levels of DHPS. We subsequently discovered that blockade or knockdown (KD) of DHPS or SLC3A2 reduced BC spheroid growth. Interestingly, spheroids stimulated with exogenous fibronectin were less sensitive to inhibition of either DHPS or SLC3A2 – an effect that could be abrogated by dual DHPS/SLC3A2 blockade or KD. In this regard, we observed that inhibition of both SLC3A2 and DHPS reduced total and hypusinated eIF5A1/2 levels most effectively. We further discovered that a subset of BC cells responded to fibronectin by increasing cytoplasmic localization of eIF5A1/2. Notably, these fibronectin-induced subcellular localization phenotypes correlated with a G0/G1 cell cycle arrest. Fibronectin-treated BC cells responded to dual DHPS/SLC3A2 blockade by shifting eIF5A1/2 localization back to a nucleus-dominant state, suppressing proliferation and further arresting cells in the G2/M phase of the cell cycle. Finally, we observed that dual DHPS/SLC3A2 inhibition increased the sensitivity of both Rb-negative and -positive BC cells to the CDK4/6 inhibitor palbociclib. Taken together, these data identify an uncharacterized mechanism through which extracellular fibronectin controls cancer cell tumorigenicity by modulating subcellular eIF5A1/2 localization. These findings provide prognostic/therapeutic utility for targeting the cooperative DHPS/SLC3A2 signaling axis to improve BC treatment responses. Citation Format: Cameron Geller, Joanna Maddela, Gabriela Ortiz-Soto, Ranel Tuplano, Farhana Runa, Yvess Adamian, Robert Güth, Luke Tomaneng, Joseph Cantor, Jonathan A. Kelber. Fibronectin, DHPS and SLC3A2 Signaling Cooperate to Control Tumor Spheroid Growth, Subcellular eIF5A1/2 Distribution and CDK4/6 Inhibitor Resistance [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-24-04.

Lelia Inés Albarracín es una destacada lingüista argentina, especializada en la lengua quichua y en educación intercultural bilingüe. Nacida en Tucumán, Argentina, es profesora en francés egresada de la Facultad de Filosofía y Letras de la Universidad Nacional de Tucumán (UNT). Ha desempeñado un papel fundamental en la enseñanza y promoción del quichua en Argentina. Durante más de una década, dictó cursos de Lingüística Quechua en la Facultad de Filosofía y Letras de la UNT. Desde 2011, es profesora de Lingüística Quichua y del Taller de Lengua Quichua en la Tecnicatura Superior Universitaria en Educación Intercultural Bilingüe con Mención en Lengua Quichua, en la Facultad de Humanidades, Ciencias Sociales y de la Salud de la Universidad Nacional de Santiago del Estero (UNSE). Esta carrera, creada a partir de un proyecto de su autoría, es la primera en Argentina enfocada en una lengua indígena con aprobación ministerial. Su labor investigativa se centra en la lingüística descriptiva, las políticas lingüísticas y el contacto entre el castellano y el quechua. Ha contribuido en publicaciones como el "International Journal of the Sociology of Language" y en obras como Lenguas e Identidades en los Andes: Perspectivas ideológicas y culturales. Entre sus obras más destacadas se encuentran: La trilogía La Quichua. Gramática, ejercicios y diccionario (Volúmenes 1 a 3), Diccionario quichua-castellano castellano-quichua (2017), Atoqkunamanta Kwentukuna - Cuentos de Zorros (2019), La compilación de Introducción al quichua santiagueño de Ricardo Nardi y La edición bilingüe del poema Pallaspa chinkas richkaqta de José Antonio Sosa. En octubre de 2023, Albarracín participó en la "International Conference on Indigenous Language Documentation, Education, and Revitalization" en la Universidad de Indiana, EE.UU., donde presentó su trabajo sobre la revitalización del quichua santiagueño y su contribución desde la lexicografía. Además, preside la Asociación de Investigadores en Lengua Quichua y ha sido reconocida por su compromiso con la preservación y enseñanza de las lenguas indígenas en Argentina.

Abstract Background: Evidence-based recommendations support a dietary pattern rich in whole grains, fruits, and vegetables with limited consumption of added sugars to improve cancer risk and mortality. The Optimal Living Program (OLP) is a prospective multiparametric lifestyle intervention that engages early-stage breast cancer patients at the time of diagnosis in risk-stratified, personalized lifestyle management. Here, we report baseline dietary patterns among women enrolled in the OLP. Methods: Upon enrollment, patients complete a questionnaire that incorporates the National Cancer Institute (NCI) Dietary Screener Questionnaire (DSQ), which queries the consumption frequency of 26 food items over the past month. Based on standard NCI DSQ scoring procedures, we calculated total daily serving equivalents of all food items within a dietary factor group. This included: 1) total daily cup equivalents of fruit and vegetables from fruit, fruit juice, salad, potatoes, beans, other vegetables, tomato sauce, salsa, and pizza, 2) total daily ounce equivalents per day of whole grains from cereal, whole grain bread, popcorn, and whole grain rice, and 3) total daily teaspoon (tsp) equivalents of added sugars from cookies/cake/pie, doughnuts, ice cream, candy, cereals, and sugar-sweetened beverages including soda, fruit drinks, and sugar/honey in coffee/tea. Results: There were 100 patients enrolled in the OLP for whom baseline DSQ data were available. The median age at diagnosis was 58 and median BMI was 27.4 mg/m2. 69 patients were white (69.0%), 14 were Black (14.0%), and 7 were Asian (7.0%). 62 patients had stage I disease (62.0%), 22 patients had stage II disease (22.0%), and 15 patients had ductal carcinoma in situ (15.0%). 74 patients had hormone receptor-positive disease (74.0%), 3 had HER2-positive disease (3.0%), and 7 had triple-negative disease (7.0%). Daily frequency of consumption of dietary factor groups are shown in Table 1. Only 29 patients (29.0%) met the current dietary guideline of 4-5 cup equivalents of fruits and vegetables per day and no patients (0%) met the guideline of more than 3 ounce equivalents of whole grains per day. Added sugar intake ranged from 0 to 4.8 teaspoon equivalents per day. Conclusion: Most women in this cohort with newly diagnosed early-stage breast cancer did not consume the recommended daily intake of fruits, vegetables, and whole grains per the 2020-2025 Dietary Guidelines and the American Institute for Cancer Research. Our findings identify these dietary factors as important targets of intervention with personalized dietary guidance at the time of breast cancer diagnosis. Table 1.<1/day1 - 2/day2 - 3/day3 – 4/day>4/dayFruits and vegetables (cup equivalents)6 (6.0%)23 (23.0%)28 (28.0%)14 (14.0%)29 (29.0%)Whole grains (ounce equivalents)63 (63.0%)29 (29.0%)8 (8.0%)0 (0%)0 (0%)Added sugar (tsp equivalents)32 (32.0%)35 (35.0%)22 (22.0%)6 (6.0%)5 (5.0%)Sugar-sweetened beverages (tsp equivalents)62 (62.0%)21 (21.0%)15 (15.0%)2 (2.0%)0 (0%) Citation Format: Sherry Shen, Johnny Allsop, Erica Salehi, Cara Anselmo, Stacie Corcoran, Jill Clayton, Andrea Smith, Melissa Emerzian, Mark Robson, Neil Iyengar. Baseline dietary patterns among women with newly diagnosed early-stage breast cancer enrolled in the Optimal Living Program [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-09-05.

Abstract Introduction Premenopausal women diagnosed with hormone receptor-positive (HR+)/HER2-negative (HER2-) early breast cancer (EBC) face a significantly higher risk of cancer recurrence and mortality compared to older women, particularly those diagnosed under the age of 40. The underlying causes behind this disparity remain largely unknown. Material and methods We retrospectively select tumour samples from patients (pts) diagnosed with HR+/HER2- EBC at Hospital Clinic (Barcelona, Spain) from May 2014 to March 2020 who had a PAM50/Prosigna assay (Veracyte) previously performed. This assay examines the expression of 50 genes involved in important breast cancer signaling pathways, as well as the intrinsic subtypes (IS) and the Risk of Recurrence (ROR) score. Our primary objective was to compare the distinct clinicopathological and molecular characteristics of HR+/HER2- EBC between two age groups: patients under 40 years old (Young EBC or YEBC) and those 40 years old and above (Older EBC or OEBC). Disease-free survival (DFS) was defined as the time between diagnosis and the first recurrence. Comparisons between groups were carried out using chi-square tests (categorical variables). Additionally, we performed a two-class unpaired Significance Analysis of Microarrays (SAM) with a false discovery rate (FDR) less than 5% to identify genes with significantly different expression between YEBC and OEBC. The statistical significance level was set at less than 0.05. Results A total of 441 tumor samples from 420 patients were included in the analysis, with 5% (22/441) corresponding to YEBC. With a median follow-up of 64.5 months, there were 20 breast cancer (BC) recurrences (4.8%), 12 second cancers (2.9%) and 5 BC-related deaths (1.2%), all occurring in the OEBC group. Table 1 provides an overview of the main clinico-pathological and molecular characteristics. YEBC tended to have larger tumors, with 45.5% (10/22) measuring over 2 cm compared to 36.1% (151/419) in OEBC (p=0.376). YEBC also had a higher proportion of grade 3 tumors (18.18% versus 3.1% in OEBC, p=0.418) and lower expression of estrogen receptor (ER) as determined by immunohistochemistry (mean of 72.28% vs 88.36%, p=0.004). Regarding the PAM50 IS, there was a difference observed between YEBC and OEBC (p < 0.001). Specifically, YEBC patients exhibited a tendency towards a higher proportion of Luminal B tumors (54.6% versus 38.9% in OEBC, p=0.144), as well as non-Luminal subtypes such as Basal-like (18.2% versus 0.95% in OEBC, p< 0.001) and HER2E (4.6% versus 0.7% in OEBC, p=0.186). YEBC tended to have higher ROR (p=0.167), and to receive chemotherapy in a higher proportion, especially in the intermediate-risk group (p=0.004). In YEBC tumours, SAM analysis (p < 0.05) showed an overexpression of genes mainly related with proliferation (i.e., RRM2, MELK, MIK67), cell cycle progression (i.e., KNTC2, CDC20, MYBL2) and apoptosis inhibition (i.e., BIRC5). In OEBC there were an overexpression of genes related with the oestrogen receptor-signalling pathway (i.e., ESR1, NAT1, FOXA1, PGR). Luminal B tumours in YEBC showed an upregulation of genes related to proliferation, migration, and poor prognosis (i.e., KRT17, KRT5) compared to OEBC. However, since there were no recurrences in the YEBC group, differences in terms of DFS between the groups could not be calculated. Principio del formulario Final del formulario Conclusions YEBC exhibited a more advanced stage and a more aggressive intrinsic phenotype compared to OEBC. Additionally, these tumors showed a tendency to upregulate genes involved in proliferation, cell cycle progression, and survival, while downregulating genes related to hormone signaling pathways. These molecular characteristics may help explain the worse prognosis of YEBC compared to OEBC. However, further research is necessary to delve into the differential genomic characteristics that contribute to the unfavorable prognosis observed in patients diagnosed with HR+ EBC before the age of 40. Key clinical and molecular features in 441 biopsies Citation Format: Francisco Javier Muñoz-Carrillo, José Antonio Sola, Carme Crous, Esther Sanfeliu, Isabel Garcia-Fructuoso, Elia Seguí, Teresa Gorría, Raquel Gómez-Bravo, Barbara Adamo, Tomás Pascual, Olga Martínez-Sáez, Francesco Schettini, Pablo Rivera, Rosalía Cayuela, Montserrat Muñoz, Núria Chic, Maria Vidal. Clinico-Pathological and Molecular Characterization of Early Hormone Receptor-Positive Breast Cancer in Young Women [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-01-13.

Abstract Purpose: Patients with triple negative breast cancer (TNBC) with residual disease after neoadjuvant chemotherapy (NAC) have high risk of recurrence with prior data suggesting improved outcomes with capecitabine. Targeted agents have demonstrated activity across multiple cancer types. BRE12-158 was a phase 2, multicenter trial that randomized TNBC patients with residual disease after NAC to genomically-directed therapy vs. treatment of physician choice (TPC). Patients and Methods: From March 2014 to December 2018, 197 patients were enrolled. Residual tumors were sequenced using a next generation sequencing (NGS) test. A molecular tumor board adjudicated all results. Patients were randomized to 4 cycles of genomically-directed therapy (arm A) vs. TPC (arm B). Patients without a target were assigned to arm B. Primary endpoint was 2-year disease free survival (DFS) among randomized patients. Secondary/exploratory endpoints included: distant disease free survival (DDFS), overall survival (OS), toxicity assessment, time-based evolution of therapy, and drug-specific outcomes. Results: 193 patients were randomized or were assigned to arm B. The estimated 2-year DFS was 56.6% (95%CI:0.45-0.70) for arm A vs. 62.4% (95%CI:0.52-0.75) for randomized arm B. No difference was seen in DFS, DDFS, or OS for the entire or randomized populations. There was increased uptake of capecitabine for TPC over time. Patients randomized later had less distant recurrences. ctDNA status remained a significant predictor of outcome with some patients demonstrating clearance with post-neoadjuvant therapy. Conclusion: Genomically directed therapy was not superior to TPC for patients with residual TNBC after NAC. Capecitabine should remain the standard of care; however, the activity of other agents in this setting provides rationale for testing optimal combinations to improve outcomes for this high-risk population. ctDNA should be considered a standard covariate for trials in this setting. Citation Format: Bryan P Schneider, Guanglong Jiang, Tarah J Ballinger, Fei Shen, Christopher Chitambar, Rita Nanda, Carla Falkson, Filipa C Lynce, Christopher Gallagher, Claudine Isaacs, Marcelo Blaya, Elisavet Paplomata, Radhika Walling, Karen Daily, Reshma Mahtani, Michael A Thompson, Robert Graham, Maureen E Cooper, Dean C Pavlick, Lee A Albacker, Jeffery Gregg, Jeffery P Solzak, Yu-Hsiang Chen, Casey L Bales, Erica Cantor, Bradley A Hancock, Nawal Kassem, Paul Helft, Bert O'Neil, Anna Maria Storniolo, Sunil Badve, Kathy D Miller, Milan Radovich. BRE12-158: A post-neoadjuvant, randomized phase 2 trial of personalized therapy vs. treatment of physician’s choice for patients with residual triple negative breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD9-10.

RESEÑAS de : Alguacil González-Aurioles, Jorge, Gutiérrez Gutiérrez, Ignacio (eds.), Constitución: norma y realidad. Teoría constitucional para Antonio López Pina, Madrid: Marcial Pons, 2014, 493 págs. Carmonas Contreras, Ana (Dir.), El lugar de las macro-regiones en el marco de la cooperación territorial europea: presente y futuro, Consejería de la Presidencia.Junta de Andalucía, Sevilla, 2014. Castellá Andreu, Josep M.a (ed.), Derecho constitucional básico, Barcelona: Huygens, 2014. Cea Navas, Ana Isabel / Enríquez Sánchez, José María (eds.), El ciudadano espectador: derechos humanos y cine, Universidad Europea Miguel de Cervantes, Servicio de Publicaciones, Valladolid, 2012. Enríquez Sánchez, José María; Muñoz de Baena Simón, José Luis; Otero León, Lourdes; Pérez Rodríguez, Cristina; Santos Esteban, Ana Belén; Ferrari Nieto, Enrique, Educación plena en Derechos Humanos, Madrid, Trotta, 2014. Fiss, Owen, Los mandatos de la justicia. Ensayos sobre Derecho y derechos humanos,Marcial Pons, Madrid, 2013. Fondevilla Marón, Manuel: La disolución de la soberanía en el ámbito estatal, Reus, Madrid, 2014. Gómez Corona, Esperanza: La propia imagen como categoría constitucional, Thomson Reuters Aranzadi, Navarra, 2014. González Trevijano, Pedro J. / Núñez Rivero, Cayetano / Goig Martínez, Juan Manuel, El Estado autonómico español, Dyckinson, Madrid, 2014, p. 241. Gutiérrez, Ignacio/ Alguacil, Jorge / Reviriego, Fernando / Salvador, María, Elementos de Derecho constitucional español, Marcial Pons, Madrid, 2014. Gutiérrez Gutiérrez, Ignacio (Coord.). La democracia indignada: tensiones entre voluntad popular y representación política, Comares, Granada, 2014, XVI + 157 págs. Hauriou, Maurice, La soberanía nacional, Marcial Pons, Madrid, 2013. López Pina, Antonio. El orden de la información, Lisboa: Juruá, 2013. Martín Morales, Ricardo: Las propiedades paradójicas del Derecho constitucional, Cívitas Thomson Reuters, 2013 Martín Oviedo, José María, El Consejo de Estado durante el régimen constitucional (1808 -2012), Consejo de Estado y Agencia Estatal Boletín Oficial del Estado, Madrid, 2013. Martínez Otero, Juan M.ª La protección jurídica de los menores en el entorno audiovisual. Respuestas desde el Derecho a los desafíos de los nuevos medios audiovisuales y digitales, Thomson Reuters Aranzadi, Navarra, 2013. Niño Estébanez, Roberto. La ejecución en España de las sentencias del Tribunal Europeo de Derechos Humanos, Madrid: Fe d’erratas 2014. Pinelli, Cesare / Presno, Miguel, Crisis de la representación y nuevas vías de participación política, Fundación Coloquio Jurídico Europeo, Madrid, 2014. Polo Sabau, José Ramón, El estatuto de las confesiones religiosas en el Derecho de la Unión Europea, Dykinson, Madrid, 2014. Polo Sabau, José Ramón, Dimensiones de la libertad religiosa en el Derecho español, Bosch, 2014. Requejo Rodríguez, Paloma, Derechos y espacio público, Oviedo: Procuradora General del Principado de Asturias/Universidad de Oviedo, 2013. Ruipérez Alamillo, Javier, Reforma versus revolución. Consideraciones desde la teoría del Estado y de la Constitución sobre los límites materiales a la revisión constitucional,Porrúa, México, 2014. Sáenz Royo, Eva, Desmontando mitos sobre el Estado Autonómico, Marcial Pons, Madrid. Barcelona, 2014. Serra Giménez, Francisco, El Derecho en la época constitucional. Un ensayo de interpretación, Madrid, Dykinson, 2013. Sosa Wagner, Francisco, Juristas y enseñanzas alemanas I, 1945-1975, Marcial Pons, Madrid, 2013.

Abstract Background: Diet is a modifiable risk factor for breast cancer risk and mortality. Current guidelines recommend a diet that provides a diverse array of nutrients, comprised predominantly of fruits/vegetables and whole grains, with limited added sugar. The Healthy Living Program (HLP) is a clinical program at Memorial Sloan Kettering Cancer Center for patients with early-stage breast cancer that offers longitudinal, personalized lifestyle management starting at the time of diagnosis. Here, we report dietary patterns among the HLP cohort and association with baseline body mass index (BMI). Methods: We included all patients enrolled in the HLP from September 2020-February 2022. At the time of enrollment, participants complete a survey containing the National Cancer Institute (NCI) Dietary Screener Questionnaire (DSQ), which consists of consumption frequency questions for 26 food items over the past month. Total daily intake equivalents are calculated for foods from every diet factor group according to standard NCI DSQ scoring as follows: 1) Total daily cup equivalents of fruits/vegetables, which includes fruit, fruit juice, salad, potatoes, beans, other vegetables, tomato sauce, salsa, and pizza; 2) Total daily ounce equivalents of whole grains, which includes cereal, whole grain bread, whole grain rice, and popcorn; 3) Total teaspoon (tsp) equivalents of added sugars from candy, doughnuts, cookies/cake/pie, cereal, ice cream, and sugar-sweetened beverages including soda, fruit drinks, and sugar/honey in coffee/tea. Adherence to recommended daily intake of fruits/vegetables, whole grains, and added sugars was assessed as per the 2020-2025 Dietary Guidelines, the American Institute for Cancer Research, and the World Health Organization guidelines. Patient and tumor characteristics were abstracted from medical records. Results: Among the 399 patients included, the median age at diagnosis was 58 and median baseline BMI was 26.1 kg/m2. 45 patients had carcinoma in situ (11.3%), 296 had stage I disease (74.2%), 51 had stage II disease (12.8%), and 7 had stage III disease (1.8%). 316 had hormone-receptor positive disease (89.3%), 24 had HER2-positive disease (6.8%), and 26 had triple-negative disease (7.3%). 106 participants (27%) met the guideline recommendation of ≥4-5 cup equivalents of fruits/vegetables daily and 3 participants (0.8%) met the guideline recommendation of ≥3 ounces equivalents of whole grains daily. All patients in the cohort met the guideline recommendation of < 6 tsp equivalents of added sugars daily. Only 2 patients (0.5%) met guidelines for all three diet factors. Baseline BMI was significantly higher among patients who did not meet the recommended fruit/vegetable intake than among those who did (26.9 kg/m2 vs. 24.5 kg/m2, p=0.016). There were no significant differences in BMI between those who did and did not adhere to the other diet factor guidelines and no significant association between tumor stage or histology and dietary guideline adherence. Conclusion: Most patients with early-stage breast cancer did not meet the recommended daily intake of fruits/vegetables or whole grains. Participants who did not meet the fruit and vegetable intake guideline had significantly higher BMI at diagnosis. These findings indicate that lifestyle assessment near the time of breast cancer diagnosis identifies patients that could benefit from personalized dietary interventions to optimize prognostic factors such as BMI. Citation Format: Bethina Liu, Sherry Shen, Erica Salehi, Yuan Chen, Nicolas Toumbacaris, Johnny Allsop, Cara Anselmo, Stacie Corcoran, Bridget Kelly, Rocco Magnoli, Andrea Smith, Melissa Emerzian, Julia Brockway-Marchello, Doreen Bacotti, Mark E. Robson, Neil M. Iyengar. Dietary patterns among women with early-stage breast cancer from the Healthy Living Program [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-08-07.

<strong>ABSTRACT</strong> Introduction: Vitamin D supplementation during the critical illness for patients with vitamin D deficiency has been studied yet not fully. Daily supplementation of the recommended dietary allowance (RDA) of vitamin D slightly improve the 25(OH) D serum concentrations in those patients with vitamin D deficiency. Methodology: A prospective observational study included 56 consecutive patients who admitted to the critical care department ICU, Cairo University. Patients were analyzed for serum level of 25-hydroxy vitamin D using ELISA technique and calculating APACHE II score on admission and SOFA score on admission (SOFA 0), after 48 hour (SOFA 1) and at discharge (SOFA 2). Results: The mean age of the studied patients was 63.2&plusmn;17.4 years,42 (75%) were males and 14 (25%) were females. The mean duration of hospital stay was 13.6&plusmn;7 days with mean APACHE II score and SOFA on admission, 48 hours and 96 hours post admission. &nbsp;The mean value of vitamin D in the whole studied population was 19.01&plusmn;13.95 ng/ml. The levels showed insignificant statistical difference between male and female genders (18.9 versus 19.2 ng/ml,p value 0.9). The mortality rate was 7.14% (out of the studied 56 patients 4/56 patients. By comparing the length of hospital stay (LOS), APACHE II, SOFA scores and vitamin D level between survivors and non-survivors; there was a statistically significant higher APACHE II score, SOFA scores (SOFA 0, SOFA 1and SOFA2) and a lower vitamin D level in non-survivors. vitamin D insufficiency is commonly observed in the critically ill patients. Vitamin D levels were found to be significantly lower in the critically ill non-survived patients and correlated significantly to APACHE II score on admission and SOFA scores. A cut off value of 9.9 ng/ml was adequately predictive for 28 days&rsquo; survival with sensitivity of 72.5% and specificity of 75%.. <strong>Key words:&nbsp; </strong>Vitamin D, RDA, SOFA, Cairo University, APACHE. <strong>REFERENCES</strong> Jones, G. Vitamin D. Modern Nutrition in Health and Diseases, 11th ed.; Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L., Ziegler, T.R., Eds.; Lippincott Williams and Wilkins: Philadelphia, PA, USA, 2012; pp. 278&ndash;292. Vieth, R.; Cole, D.E.; Hawker, G.A.; Trang, H.M.; Rubin, L.A. Wintertime vitamin D In sufficiency is common in young Candian women, and their vitamin D intake does not prevent it. Eur. J. Clin. Nutr. 2001, 55, 1091&ndash;1097. Holick, M.F. Vitamin D deficiency. New Engl. J. Med. 2007, 357, 266&ndash;281. Sch&ouml;ttker, B.; Haug, U.; Schomburg, L.; K&ouml;hrle, J.; Perna, L.; M&uuml;ller, H.; Holleczek, B.; Brenner, H. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer and respiratory disease mortality in a large cohort study. Am J Clin Nutr. 2013 Apr;97(4):782-93. Belenchia, A.M.; Tosh, A.K.; Hillman, L.S.; Peterson, C.A. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: A randomized controlled trial. Am. J .Clin. Nutr. 2013, 97, 774&ndash;781. Ramagopalan, S.; Heger, A.; Berlanga, A.J.; Maugeri1, N.J.; Lincoln, M.R.; Burrell1, A.; Handunnetthi1, L.; Handel1, A.E.; Disanto, G.; Orton, S.M.; et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 2010, 20, 1352&ndash;136. Chernecky CC, Berger BJ. Vitamin D (Cholecalciferol) &ndash; plasma or serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:1182-1183. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J ClinEndocrinolMetab 2011; 96:1911. Swapna Gurrapu and Estari Mamidala<strong>.</strong> Medicinal Plants Used By Traditiona MedicinePractitioners in the Management of HIV/AIDS-Related Diseases in Tribal Areas of AdilabadDistrict, Telangana Region. The Ame J Sci &amp; Med Res.2016:2(1):239-245. doi:10.17812/ajsmr2101. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A, M&uuml;nch A, Warnkross H, Stojakovic T, Bisping E, Toller W, Smolle KH, Berghold A, Pieber TR, Dobnig H.Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014 Nov&nbsp; 12;312(18):1932. Holmes EW, Garbincius J, McKennay KM. Analytical variability among methods for the measurement of 25-hydroxyvitamin D: still adding to the noise. Am J ClinPathol 2013; 140:550. Gallagher JC, Jindal PS, Smith LM. Vitamin D does not increase calcium absorption in young women: a randomized clinical trial. J Bone Miner Res 2014; 29:1081. Gallagher JC, Jindal PS, Smith LM. Vitamin D supplementation in young White and African American women. J Bone Miner Res 2014; 29:173. Lucidarme O, Messai E, Mazzoni T, Arcade M, Du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Medicine. 2010;36(9):1609&ndash;1611 Yetley EA. Assessing the vitamin D status of the US population. Am J ClinNutr 2008; 88:558S. Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab. 2003;88:4623&ndash;4632. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. The New England Journal of Medicine. 2009;360(18):1912&ndash;1914. Hypp&ouml;nen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J ClinNutr 2007; 85:860. Looker AC, Pfeiffer CM, Lacher DA, et al. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J ClinNutr 2008; 88:1519. Rafael Barberena Moraes,I, Gilberto Friedman,I Iuri Christmann Wawrzeniak,I Leonardo S. Marques,I Fabiano M&aacute;rcio Nagel,I Thiago Costa Lisboa,I and Mauro Antonio CzepielewskiII. Vitamin D deficiency is independently associated with mortality among critically ill patients. Clinics (Sao Paulo). 2015 May; 70(5): 326&ndash;332.

&#x0D; &#x0D; &#x0D; En el mundo andino, el Qhapac Ñam, el camino principal o del Inca, refiere a una red ancestral de rutas y de estructuras de comunicación, intercambio y defensa, cuya extensión conecta más de cuatro mil kilómetros a lo largo de la cordillera andina. Este sistema vial andino, que se consolidó en el siglo XV con el incanato, y que enlaza a través de sus senderos a Ecuador, Perú, Colombia, Bolivia, Chile y Argentina, resulta también una red para intercambiar e interconectar saberes (Sosa et al., 2020). Se trata de un espacio intenso (Vilca, 2020) que involucra modos de sentir y pensar el mundo; es decir, supone prácticas artísticas, culturales, sociales, políticas y económicas localizadas geopolíticamente. Así, es posible delimitar entre las regiones culturales y literarias continentales, la región andina (Rama, 1984; Palermo y Altuna, 1996) cuyos sentidos exceden los meros criterios geográficos y se acercan, más bien, a la forma de configurar los imaginarios culturales y sus procesos de identificación de manera situada.&#x0D; Advertimos que los saberes propios de lo que, hace unas décadas, se entendían como pueblos testimonios (Ribeiro, 1969; 2017) o de lo que, en los últimos años, se aglutina bajo la denominación de pueblos del Abya Yala (Arias, 2012; Muyulema, 2019) se conectan, dialogan y tensionan con los conocimientos inherentes a la modernidad. A propósito de estos contactos, las reflexiones de Ángel Rama (1984) y Antonio Cornejo Polar (1994) son fundacionales en el campo de la crítica y la teoría literarias latinoamericanas, entre otros referentes destacados de este campo (Bueno Chávez, 2012; Lienhard, 1990; Noriega Bernuy, 2011 y 2012; Zevallos Aguilar, 2009 y 2015). Asimismo, resulta ineludible la revisión de la producción literaria y antropológica de José María Arguedas, quien sin duda marca un punto de inflexión en el vínculo entre los saberes nativos, los mestizos y los modernos, que se hallan siempre en conflicto, desplazamiento y yuxtaposición. Como sucede con los senderos del Qhapac Ñam ̧ es ineludible volver a transitar los caminos fundacionales que interconectan formas de comunicación y de conocimientos; pero también este andar, en la actualidad, significa el desafío de proponer nuevas preguntas y abordajes, revisitar el corpus canonizado, proponer la incorporación de otros textos y entablar nuevos diálogos o formas de conexión.&#x0D; &#x0D; &#x0D;

Abstract Introduction: Paclitaxel induced peripheral neuropathy (TIPN) is one of the most important survivorship issues of cancer patients with the potential to substantially impact quality of life. TIPN can lead to dose reductions, early cessation, and has the potential to compromise treatment efficacy. We previously reported both rare (SBF2) and common germline (FCAMR) predictors for TIPN in patients of African descent through whole-exome sequencing (WES) and a genome-wide association study (GWAS), respectively, in the adjuvant, randomized phase III breast cancer trial, E5103. These predictors are now being evaluated in the prospective ECOG-ACRIN trial EAZ171 (NCT04001829). We have also previously reported our evaluation of common germline variants for patients of European descent through GWAS in E5103 with validation in another adjuvant breast cancer trial, E1199. Herein, we evaluated for rare variants that were associated with risk of TIPN in patients of European ancestry from WES in E5103. Methods: Gene-based rare variant analyses using SKAT were performed to compare select cases of severe TIPN (n=172) and controls without any evidence of TIPN (n=170) derived from E5103. Cases were defined as those with at least grade 3 TIPN and controls were optimally. matched by demographic and risk factors and had no reported evidence for TIPN of any grade. Germline WES was conducted using Ion Proton™ Sequencers from Life Technologies with an average &amp;gt;100X coverage of the exome. Rare variants with a minor allele frequency &amp;lt;3% predicted to be deleterious by protein prediction programs were retained for the analysis. 7,278 genes passed quality control and were included in the analysis, setting the threshold for significance at a p-value &amp;lt; 6.87 ×10-6 after Bonferroni correction. Results: Cytochrome P450 oxidoreductase (POR) was significantly associated with an increased risk of grade 3+ TIPN (p =1.82 ×10-6). Six variants predicted to be deleterious in POR were identified in the study population. Paclitaxel is predominately metabolized by cytochrome P450 (CYP) 2C8 and 3A4. A functional cytochrome P450 oxidoreductase is required for the catalytic activities of all 57 CYP family members to metabolize drugs, xenobiotics, and steroid hormones. Conclusion: Rare variants in cytochrome P450 oxidoreductase predicted an increased risk of severe TIPN in patients receiving paclitaxel. These rare variants in POR may modulate the catalytic activities of P450 enzymes that are responsible for paclitaxel metabolism and have a striking biological rationale as contributors to TIPN. Work is ongoing to validate these findings mechanistically and to identify strategies to nullify the impact of these deleterious variants. Citation Format: Fei Shen, Guanglong Jiang, Laura Gardner, Gloria Xue, Santosh Philips, Reynold Ly, Osei Wilberforce, Xi Wu, Erica Cantor, Chau Dang, Donald Northfelt, Todd Skaar, Kathy D. Miller, George Sledge, Bryan P Schneider. Cytochrome P450 reductase gene, POR, associated with paclitaxel induced peripheral neuropathy in patients of European ancestry from the adjuvant breast cancer trial, ECOG-ACRIN E5103 [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-08-02.

Abstract Breast cancer (BC) is among the most commonly diagnosed cancer in women and a leading cause of cancer death worldwide. Hispanic/Latina women represent a heterogeneous group with diverse genetic backgrounds, including varying proportions of Native American, European, African and to a lesser extent Asian ancestry. In the US, Hispanic and African American women have lower BC incidence overall yet higher incidence of triple negative breast cancer (TNBC). Furthermore, African American and Hispanic women tend to present with more aggressive disease, at younger ages and worse survival compared to women of European ancestry. These disparities have been attributed to biologic and non-biologic socioeconomic factors. Genomic analyses of Hispanic Mexican (HM) women have revealed specific genetic signatures distinct from those of non-Hispanic women. These variations include AKT kinase mutations activating PI3K/AKT/mTOR signaling pathway and PI3KCA mutations which could potentially benefit from targeted therapies. 4EBP1 phosphorylation by mTORC1 is generally considered a marker of activated mTOR signaling and high levels in tumors associate with worse outcomes in different cancers. To evaluate clinical significance of PI3KCA expression and PI3K/AKT/mTOR signaling, we performed immunohistochemical (IHC) analyses of tissue microarrays (TMA) including 272 BC patient samples from HM women. Protein expression of PI3KCA and p4EBP1 were evaluated quantitatively by receiver operator characteristics (ROC) curves based on area under the curve (AUC) as well as sensibility and specificity. p4EBP1 levels were associated with clinicopathological characteristics. Chi-squared and Fisher’s Exact tests showed higher p4EBP1 expression correlated with estrogen (P=0.001) and progesterone receptor negative BC (P=0.003), TNBC (P&amp;lt;0.001), tumor size (P&amp;lt;0.090), and advanced stage (P&amp;lt;0.001). PI3KCA expression was positively correlated with 4EBP1 expression (P=0.044) as shown by Mann Whitney U tests; but PI3KCA lacked prognostic value after screening through ROC curves. However, uni- and multi-variate Cox regression analyses did show that increased 4EBP1 expression correlates with worse OS. Overall, our study indicates that higher p4EBP1 expression is an independent prognostic factor of worse OS in BC patients. The activation of 4EBP1 may result from several upstream oncogenic alterations or mutations, representing a potential therapeutic target and biomarker. Further research is necessary to better define biological differences in Hispanic women to advance understanding and targeting of health disparities. [Funded by California Breast Cancer Research Program Idea Award B27IB3869, JCCC Breast Cancer Award, Hickey Family Foundation, NCI U54 CA143930, Team Research Grant, UCLA TDG, CIRM DISC2-14166]. Citation Format: Mario Morales Martinez, Giovanny Soca-Chafre, Altagracias Maldonado-Valenzuela, Clara M Rivera-Pazos, Gabriela Antonio-Andres, Mayra Montecillo-Aguado, Georgina Rocha-Lopez, Berenice Alcala-Mota-Velazco, Anel Gomez-Garcia, Madhuri Wadehra1, Richard J Pietras, Sergio Gutierrez-Castro, Sara Huerta-Yepez, Diana Marquez-Garban. Evaluation of PI3K/AKT/mTOR pathway signaling as a prognostic indicator in Hispanic Mexican women with breast cancer [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C024.

Abstract Alterations of KRAS are found in approximately one in seven of all human cancers, making KRAS one of the main oncogenic drivers in cancer. Gain-of-function missense mutations in KRAS are found in ~90% of pancreatic cancer, ~40% of colorectal cancer and ~30% of lung adenocarcinoma. In addition, focal high-level amplification of the KRAS wild-type (wt) allele, an alternative means of activating this oncoprotein, is observed in ~7% of cancers and lacks effective targeted therapies. Thus, there is an urgent need to identify effective therapies to address KRAS-driven tumors. Recently, we have reported the identification of compounds active against a broad range of oncogenic KRAS variants (KRASmulti) that selectively inactivate downstream signaling and tumor growth (Kim et al., Nature 2023). Herein we describe BI 3706674, a novel, potent and orally available small molecule inhibitor of the KRAS oncogene. BI 3706674 binds non-covalently to multiple KRAS mutant alleles, including the KRAS wt allele, in the GDP-bound state and thereby disrupts oncogenic signaling. Using several in vitro assays, we show that BI 3706674 is a) highly selective for KRAS vs HRAS or NRAS; b) blocks the interaction between KRAS mutant/wt and its guanidine exchange factor (GEF) SOS1 and c) shows potent antiproliferative activity in isogeneic cell lines that are dependent on various KRAS mutant alleles. In two large cancer cell line panels, BI 3706674 potently and selectively inhibits proliferation of KRAS mutant cancer cell lines as well as cancer cell lines with an amplification of the KRAS wt allele. Significant pharmacodynamic (PD) biomarker modulation (including inhibition of ERK1/2 phosphorylation and DUSP6 mRNA down-regulation) was observed in cell lines with a KRAS wt relative copy number (CN) &amp;gt; 10, treated with BI 3706674. Amplification of the KRAS wt allele is most frequently observed in gastric (~5%), esophageal (~13%) and gastroesophageal junction cancers (~12%). BI 3706674 was well-tolerated and showed dose-dependent efficacy in cell line-derived and patient-derived xenograft models (CDX and PDX) of human gastric cancer with a KRAS wt CN &amp;gt; 10. A twice daily oral dose of 30 mg/kg was sufficient to induce significant tumor regression. BI 3706674 treatment induced PD biomarker modulation (including inhibition of ERK1/2 phosphorylation, DUSP6 down-regulation, repression of the MAPK Pathway Activity Score (MPAS) signature and Ki67 reduction) in two KRAS wt amplified gastric cancer xenograft models. The depth and duration of PD biomarker responses following treatment correlated well with the doses used in the respective efficacy studies. Finally, these results support the clinical use of biomarkers such as the MPAS signature score and Ki67 to investigate treatment effects elicited by BI 3706674 in tumor biopsies. The KRASmulti inhibitor BI 3706674 is undergoing IND enabling studies and is intended to target tumors driven by KRAS wt amplifications as well as oncogenic KRAS missense mutations. Citation Format: Antonio Tedeschi, Lorenz Herdeis, Valeria Santoro, Fabio Savarese, Birgit Wilding, Matthias Treu, Julian Fuchs, Joachim Bröker, Tobias Wunberg, Michael Gmachl, Rumpel Klaus, Fiorella Schischlik, Jesse Lipp, David H. Peng, Mariah Williams, Charles Deckard, Vandhana Ramamoorthy, Joseph R. Daniele, Jaffer A. Ajani, Funda Meric-Bernstam, Christopher P. Vellano, Joseph R. Marszalek, Timothy P. Heffernan, Darryl McConnell, Mark Pearson, Norbert Kraut, Dorothea Rudolph. BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr A085.

Tabla de contenido Editorial Especies multiprop&oacute;sitos propuestas para los dise&ntilde;os de forester&iacute;a an&aacute;loga en Guant&aacute;namo y el Instituto de Investigaciones Agro-Forestales / Multipurpose species proposals for the design of analog forestry in Guant&aacute;namo and research Institute Agro-Forestales. M.Sc. Lourdes Sordo-Olivera, Dr.C. Wilmer Toirac-Arguelle, T&eacute;c. Eider Su&aacute;rez-Ramos y Dra.C. Orlidia Hechavarr&iacute;a-Kindel&aacute;n Lluvias &aacute;cidas y acidificaci&oacute;n en los pinares de Alturas de Pizarra, Estaci&oacute;n Amistad / Acid rains and acidification in the pinegroves of height of slate Amistad Station. Dr. Ariel T. Plasencia-Puentes, Dra. C. Yilian Morej&oacute;n, Dr. Antonio Escarr&eacute;-Esteve, Ing. Arsenio Renda- Sayoux, M.Sc. Yolanis Rodr&iacute;guez-Gil, T&eacute;c. Manuel Arteaga-Gonz&aacute;lez, T&eacute;c. Dionisio Cruz-Delgado, Dr. Jos&eacute; L. Peralta-Vital e Ing. Yaciel Mart&iacute;nez-P&eacute;rez Estimaci&oacute;n de la biomasa de ramas verde de las plantaciones de Pinus maestrensis Bisse en la provincia de Granma, Cuba / Estimate of the biomass of green branch of the plantations of Pinus maestrensis Bisse at the Granma province, Cuba. Dr.C. Wilmer Toirac-Arguelle, Dra.C. Juana T. Su&aacute;rez-Sarria, Dr,C. Jos&eacute; A. Bravo-Iglesias, Dr.C. H&eacute;ctor Barrero-Medel, Dr.C. Alberto Vidal-Corona y Dr.C. Arlety Ajete- Hern&aacute;ndez Comportamiento de la capacidad germinativa de Hibiscus elatus Sw. en cinco localidades de Granma y Holgu&iacute;n, Cuba / Capacity germinative behavior of Hibiscus elatus Sw. in five locations of Granma and Holguin, Cuba. Ing. Leydis Santos-Chac&oacute;n, M.Sc. William Santos-Chac&oacute;n, M.Sc. Yenia Molina-Pelegr&iacute;n, M.Sc. Adonis Sosa-L&oacute;pez y T&eacute;c. Marina Rodr&iacute;guez-Guerra Biomasa y carbono retenido en una finca forestal del corredor xerof&iacute;tico, Guant&aacute;namo, Cuba / Biomass and retained carbon in a forest farm of the xerophytic runner, Guant&aacute;namo, Cuba. Dra.C. Arlety Ajete-Hern&aacute;ndez, Dr.C. Wilmer Toirac-Arguelles, Dra.C. Orlidia Hechavarr&iacute;a-Kindel&aacute;n, Esp.V&iacute;ctor M. Fuentes-&Uacute;trias, Dr.C. Jos&eacute; A. Bravo-Iglesias2y M.Sc. Abilio Ofarril-Coolebrook Xiloteca y espermoteca: herramienta did&aacute;ctica para el estudio de la biodiversidad forestal / Wood collection and seed collection: didactic tool for forest biodiversity study. M.Sc. Gardenis Merlan-Mesa, M.Sc. Liliana Caballero-Land&iacute;n, M.Sc. Mar&iacute;a M. Mart&iacute;nez-Flores y Dra. Katia Manzanares-Ayala Aprovechamiento del follaje de Eucalyptus sp. para la producci&oacute;n de aceite esencial terap&eacute;utico / To use of leaves Eucalyptus sp. for production therapheutical essential oils. Dr. Rolando Quert-&Aacute;lvarez, T&eacute;c. Jos&eacute; I. Calder&iacute;n-Rodr&iacute;guez, Esp. Manuel Valle-L&oacute;pez, T&eacute;c. Iris Enr&iacute;quez-Gonz&aacute;lez, T&eacute;c. Henry Recio-Cabrera y Lic. Humberto Garc&iacute;a-Corrales Diagn&oacute;stico realizado en la finca D&iacute;az Cuevas utilizando la t&eacute;cnica de Forester&iacute;a An&aacute;loga / Diagnosis made in the farm D&iacute;az Cuevas technique using analog forestry. Ing. Alquilio M. Mosquera-Figueroa, M.Sc. Andr&eacute;s Hern&aacute;ndez-Riquene, Lic. Marta A. Gonz&aacute;lez-Hern&aacute;ndez, M.Sc. Magdalena Mart&iacute;nez-Flores, T&eacute;c. Orcides Bravo-P&eacute;rez y Magalis G&oacute;mez-Le&oacute;n Regeneraci&oacute;n natural de Pinus caribaea Morelet var. caribaea Barret y Golfari para el incremento del &iacute;ndice de boscosidad en el macizo San Felipe-Los Joberos / Natural regeneration of Pinus caribaea Morelet var. caribaea Barret and Golfari for the increasement the wooded rate in San Felipe-Los Joberos massif. Ing. Pablo A. Cabrera-Rodr&iacute;guez, Dr.C. Oscar Loyola-Hern&aacute;ndez y Dr.C. Jos&eacute; A. Cardona-Fuentes Especies ap&iacute;colas presentes en la finca La Uni&oacute;n, La Aplastada, Guisa, Granma / Apicultural species present in the farm La Uni&oacute;n, La Aplastada, Guisa, Granma. M.Sc. Magalys Arcia-Ch&aacute;vez, M.Sc. Yenia Molina-Pelegr&iacute;n, M.Sc. Adonis Sosa-L&oacute;pez e Ing. Jorge L. Carmona-Licea Retenci&oacute;n de carbono por el patrimonio forestal de la Empresa Forestal Integral Cienfuegos / Retention of carbon for the forest heritage of the Integral Forest Company Cienfuegos. M.Sc. Andr&eacute;s Hern&aacute;ndez-Riquene, M.Sc. Liliana Caballero-Land&iacute;n, Ing. Alquilio Mosquera-Figueroa, Dr.C. Alicia Mercadet-Portillo y Dr.C. Arnaldo &Aacute;lvarez-Brito Estimaci&oacute;n de heredabilidades y coeficientes de variaci&oacute;n gen&eacute;tica aditiva y fenot&iacute;pica en Pinus cubensis Griseb / Estimation of heredabilities and coefficients of additive and phenotypic genetic variance in Pinus cubensis Griseb. Ing. Wilden Lahera-Fern&aacute;ndez Fenolog&iacute;a vegetativa de Coccothrinax macroglossa (Le&oacute;n) Borhidi y Mu&ntilde;iz y Copernicia hospita Mart en la provincia de Camag&uuml;ey, Cuba. Estudio preliminar / Vegetative phenology of Coccothrinax macroglossa (Le&oacute;n) Borhidi and Mu&ntilde;iz and Copernicia hospita Mart in Camag&uuml;ey province, Cuba. Preliminary study. M.Sc. Miladys Delgado-M&eacute;ndez, M.Sc. Rafael Risco-Villalobos, Lic. Lorge Acosta-Broche, Ing. Yadisleidys Consuegra-Taboada, T&eacute;c. Uberto Pel&aacute;ez-Mart&iacute;nez e Ing. Pablo Cabrera-Rodr&iacute;guez

Tabla de contenido Editorial 2 3&nbsp;Impactos asociados al cambio clim&aacute;tico en el patrimonio forestal de la Empresa Agroforestal Mayar&iacute; Impacts associated to the climatic change in the forestry patrimony of the Enterprise Agroforestry Mayari Dra. Arlety Ajete-Hern&aacute;ndez, Dra. Alicia Mercadet-Portillo, Dr. Arnaldo &Aacute;lvarez-Brito, T&eacute;c. Eider Su&aacute;rez-Ramos e Ing. Fernando Jim&eacute;nez-Guti&eacute;rrez 13 Primeras experiencias sobre la interrelaci&oacute;n g&eacute;nero-cambio clim&aacute;tico en Ci&eacute;naga de Zapata, Matanzas, Cuba First experiences on gender-climate change interrelation in Ci&eacute;naga de Zapata, Matanzas, Cuba Dra. Alicia Mercadet-Portillo, Ing. Misleydis Morales-Lezcano, Dr. Arnaldo &Aacute;lvarez-Brito, T&eacute;c. Lourdes G&oacute;mez-Pulido, T&eacute;c. Carlos Y. Mil&aacute;n-Mart&iacute;nez y T&eacute;c. Natividad Triguero-Isasi 21 Pron&oacute;stico de biomasa de copa aprovechable de Pinus caribaea por metro c&uacute;bico de madera de fuste Prediction of profitablecrown biomass&rsquo;s of Pinus caribaea for m3 of shaft&rsquo;s wood Dr. Alberto M. Vidal-Corona, Dr. Rolando Quert-&Aacute;lvarez e Ing. Ger&oacute;nimo F. Avil&eacute;s-Mart&iacute;nez 29 Valoraci&oacute;n de servicios ecosist&eacute;micos de la especie Avicennia germinans (mangle prieto) Valuation of eco-systemic services of the specie Avicennia germinans (mangle prieto) Dr. Adolfo N&uacute;&ntilde;ez-Barrizonte e Ing. Digna Vel&aacute;zquez-Viera 35 Inventario flor&iacute;stico en &aacute;reas de Pinares de Mayar&iacute;, afectadas por la miner&iacute;a a cielo abierto Floristic inventary in Mayar&iacute; Pinetums areas, affected by open sky excavation M.Sc. Magalys Arcia-Ch&aacute;vez, Dr. Jos&eacute; L. Rodr&iacute;guez-Sosa, Ing. Wilden Lahera-Fern&aacute;ndez, M.Sc. Alain Puig- P&eacute;rez, Ing. Jos&eacute; L. Rodr&iacute;guez-Fonseca, M.Sc. Yenia Molina-Pelegr&iacute;n, Ing. Luis E. Gonz&aacute;lez-Barzaga,, Ing. Susana Carrazana-Quintana y M.Sc. Antonio Maga&ntilde;a-Reyes 45 Evaluaci&oacute;n de la concentraci&oacute;n microbiana del aire en el aserradero Libertad, Empresa Agroforestal Las Tunas Evaluation of the microbial concentration of the air in the sawmill freedom, Agroforestal Company Las Tunas Lic. Claudia M. Torres-Fern&aacute;ndez, Dr. Juan M. Garc&iacute;a-Delgado, T&eacute;c. Claudia de la C. Gal&aacute;n-Valenzuela y T&eacute;c. Natividad Triguero-Issasi 53 Situaci&oacute;n de los recursos gen&eacute;ticos forestales. Plan de medidas para su conservaci&oacute;n Situation of the forest genetic resources. Plan of measures for their conservation Ing. Amarilys Leyva-Hern&aacute;ndez, M.Sc. Lourdes Sordo-Olivera, Dra.C. Orlidia Hechavarr&iacute;a-Kindel&aacute;n,&nbsp;Ing. Pablo Echavarr&iacute;a-Caraballo, M.Sc. Yaumara Mi&ntilde;oso-Bonilla, Ing. &Aacute;guedo C&aacute;rdenas-Mar&iacute;n,&nbsp;Ing. Esperanza Hidalgo-Rodr&iacute;guez, T&eacute;c. Ketty Ram&iacute;rez-Hern&aacute;ndez, M.Sc. Liliana Caballero-Land&iacute;n,&nbsp;Ing. Miguel Rivero-Vega, M.Sc. Miladys Delgado-M&eacute;ndez, T&eacute;c. Uberto Pel&aacute;ez-Mart&iacute;nez, M.Sc. Adonis Sosa-L&oacute;pez, Ing. Jos&eacute; L. Figueredo-Fern&aacute;ndez y T&eacute;c. Eider Su&aacute;rez-Ramos 61 Empleo de la microrresinaci&oacute;n para la selecci&oacute;n preliminar de genotipos de alta productividad en Pinus cubensis Griseb Use of microresination for the preliminary selection of high productivity genotypes in Pinus cubensis Griseb Ing. Pedro Sotolongo-Borges, Dr. Arnaldo &Aacute;lvarez-Brito y T&eacute;c. Jos&eacute; A. Fr&oacute;meta-Isaac 67 Proyecci&oacute;n del balance neto de emisiones del sector forestal hasta 2030 Projection of the net balance sheet of forest sector until 2030 Dr. Arnaldo &Aacute;lvarez-Brito, Dra. Alicia Mercadet-Portillo y M.Sc. Yolanis Rodr&iacute;guez-Gil 75 Flora y vegetaci&oacute;n de La Ceja de Carlos, Ci&eacute;naga de la Guayabera, Parque Nacional Caguanes Flora and vegetation of the Eye of Carlos, Ci&eacute;naga de la Guayabera, Caguanes National Park M.Sc. Armando Falc&oacute;n-M&eacute;ndez, M.Sc. Ricardo Rosa-Angulo, M.Sc.Julio P. Garc&iacute;a-Lahera, M.Sc. Daily Y. Borroto-Escuela, M.Sc. Norgis V. Hern&aacute;ndez-L&oacute;pez y Dr. Alfredo Z. Dom&iacute;nguez-Gonz&aacute;lez 85 Alternativa de flujo tecnol&oacute;gico para la producci&oacute;n de elementos del m&oacute;dulo ap&iacute;cola en la carpinter&iacute;a Industria Manzanillo Alternative of technological flow for the production of elements of the beekeeping module in the carpentry i Industria Manzanillo Ing. Jos&eacute;&nbsp;L. Figueredo-Fern&aacute;ndez, Dr. Juan M. Garc&iacute;a-Delgado, Ing. Isnaudy Garc&iacute;a-Rodr&iacute;guez e Ing. Ariel R.&nbsp;Avil&eacute;s-Tamayo 93 Caracterizaci&oacute;n de especies del ecosistema Manglar en la colecci&oacute;n preservada de maderas Characterization of Manglar ecosystem species in the preserved wood collection Ing. Taimy Jim&eacute;nez-Enr&iacute;quez, Dra. Katia Manzanares-Ayala, Ing. Digna Vel&aacute;zquez-Viera y Lic. Alina&nbsp;Romeo-S&aacute;ez &nbsp;

&nbsp; Lista de &aacute;rbitros, Volumen 4 <em>Agustin Gittardi</em> Universidad Tecnol&oacute;gica Nacional Argentina &nbsp; <em>Alejandro Guerra</em> Centro de Investigaciones Marinas, Espa&ntilde;a &nbsp; <em>Alfonso Maeda</em> Unidad Nayarit del Centro de Investigaciones Biol&oacute;gicas del Noroeste, M&eacute;xico &nbsp; <em>Ana Luisa Medina</em> Universidad de Los Andes, Venezuela &nbsp; <em>Anieli Maraschi</em> Universidad Nacional de Mar del Plata, Argentina &nbsp; <em>Antonio Luna Gonz&aacute;lez</em> Instituto Polit&eacute;cnico Nacional, Mexico &nbsp; <em>Arturo Trip Quezada</em> Instituto Polit&eacute;cnico Nacional Centro Interdisciplinario de Ciencias Marinas, M&eacute;xico &nbsp; <em>Carlos Rosas </em> Universidad Nacional Aut&oacute;noma de M&eacute;xico, M&eacute;xico &nbsp; <em>Cesar Lodeiros</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador Universidad de Oriente, Venezuela &nbsp; <em>Cristian Sifuentes</em> Facultad de Ciencias de la Ingenier&iacute;a Universidad Austral de Chile, Chile &nbsp; <em>Edgar Alexander Zapata V&igrave;venes</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador &nbsp; <em>Edgar Fernando Mendoza Franco</em> EPOMEX: Campeche, M&eacute;xico &nbsp; <em>Ernesto Negrin Sosa</em> Escuela Superior Polit&eacute;cnica Agropecuaria de Manab&iacute;, Ecuador &nbsp; <em>Ever Morales</em> Escuela Polit&eacute;cnica Superior Agropecuaria de Manab&iacute; Manuel F&eacute;lix L&oacute;pez, Ecuador &nbsp; <em>Fernando Abasolo</em> Universidad T&eacute;cnica Estatal de Quevedo, Ecuador &nbsp; <em>Fernando Ram&oacute;n Isea Le&oacute;n</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador &nbsp; <em>German Robaina</em> AQUACONSULTAS, Venezuela &nbsp; <em>Georgina Chavez-Liz&aacute;rraga</em> Universidad Cat&oacute;lica Boliviana San Pablo, Bolivia &nbsp; <em>Haydelba D&rsquo;Armas</em> Universidad de Oriente, Venezuela &nbsp; <em>Iuri Moraes Neyrao</em> Universidade Estadual Paulista J&uacute;lio de Mesquita Filho, Brasil &nbsp; <em>Javier Escobar</em> Consultor Especializado Acuicultura, Colombia &nbsp; <em>Jos&eacute; Ad&aacute;n F&eacute;lix Ortiz</em> Universidad Aut&oacute;noma de Sinaloa: Mazatl&aacute;n, Sinaloa, M&eacute;xico &nbsp; <em>Jos&eacute; Javier Ali&oacute; Mingo&nbsp; </em> Universidad Laica Eloy Alfaro de Manab&iacute;, Ecuador &nbsp; <em>Jos&eacute; Manuel Mazon Suastegui</em> Centro de Investigaciones Biol&oacute;gicas del Noroeste, M&eacute;xico &nbsp; <em>Jorge C&aacute;ceres-Mart&iacute;nez</em> Centro de Investigaci&oacute;n Cient&iacute;fica y de Educaci&oacute;n Superior de Ensenada, M&eacute;xico &nbsp; <em>Jorge Cuellar</em> Escuela Superior Polit&eacute;cnica del Litoral, Ecuador &nbsp; <em>Juan Carlos V&eacute;lez</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador &nbsp; <em>Juan Jos&eacute; Bernal</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador &nbsp; <em>Luis F. Choc Mart&iacute;nez</em> Universidad de San Carlos de Guatemala, Guatemala &nbsp; <em>Luis Troccoli</em> Universidad de Oriente, Venezuela &nbsp; <em>Mairin Lemus</em> &nbsp; Instituto Superior de Formaci&oacute;n Docente Salom&eacute; Ure&ntilde;a, Rep&uacute;blica Dominicana Universidad de Oriente, Venezuela &nbsp; <em>Marcos De Donato</em> Tecnol&oacute;gico de Monterrey, M&eacute;xico &nbsp; <em>Nellis Marin</em> Instituto Oceanogr&aacute;fico de Venezuela Universidad de Oriente &nbsp; <em>Paola Barato</em> Corporaci&oacute;n Patolog&iacute;a Veterinaria, Bogot&aacute;, Colombia. &nbsp; <em>Rafael A. Tizol Correa</em> Centro Investigaciones Pesqueras, Cuba &nbsp; <em>Soraya Silva</em> Instituto Venezolano de Investigaciones Cient&iacute;ficas, Venezuela &nbsp; <em>Yanis Cruz</em> Universidad T&eacute;cnica de Manab&iacute;, Ecuador &nbsp;

Disponível em: O artigo objetivou identificar a percepção de produtores rurais de Tupã/SP sobre a legislação que implantou e regulamenta a logística reversa de embalagens de agrotóxicos, bem como as informações que têm sobre sua obrigação. Buscou-se trazer elementos contidos na legislação e considerações de diversos autores, por meio de pesquisa bibliográfica, assim como foi aplicado um formulário com 19 questões, sobre o comportamento de 20 produtores rurais frente às informações relativas à devolução das embalagens vazias de agrotóxicos. As discussões revelam que cerca de 60% dos respondentes são indiferentes, conhecem muito pouco ou desconhecem sua responsabilidade como primeiro elo da cadeia da logística reversa das embalagens vazias de agrotóxicos, talvez em virtude de falhas no processo de comunicação e na fiscalização. Sugere-se que deva haver maior empenho do Poder Público com vistas a intensificar a fiscalização e tornar mais compreensível as responsabilidades desses agricultores.PALAVRAS-CHAVE: Logística reversa, comunicação e agronegócios, embalagens vazias de agrotóxicos, legislação ambiental. ABSTRACTWith the purpose to identify the perception of farmers Tupa/SP on legislation that established and governs the reverse logistics of empty pesticide containers, as well as the information they have on their obligation. It sought to bring elements contained in the legislation and considerations of various authors, through literature, as well as a form with 19 questions about the behavior of 20 farmers in the face of information on the release of empty containers of pesticides were applied. The discussions show that about 60% of respondents are indifferent, know little or unaware of their responsibility as first link in the chain of reverse logistics of empty pesticide containers, perhaps because of flaws in the communication process and inspection. It is suggested that there should be greater commitment from the Government in order to step up surveillance and make more understandable the responsibilities of farmers.KEYWORDS: Reverse logistics, communications and agribusiness, empty pesticide containers environmental legislation. RESUMENCon el propósito de identificar la percepción del agricultor Tupa / SP en la legislación que estableció y administra la logística inversa de los envases vacíos de plaguicidas, así como la información que tienen sobre su obligación. Se intentó traer elementos contenidos en la legislación y las consideraciones de diversos autores, a través de la literatura, así como un formulario con 19 preguntas sobre el comportamiento de los 20 agricultores en la cara de la información sobre la liberación de los envases vacíos de plaguicidas se aplicaron. Los debates muestran que alrededor del 60% de los encuestados son indiferentes, saben poco o conscientes de su responsabilidad como primer eslabón de la cadena de la logística inversa de los envases vacíos de plaguicidas, tal vez debido a fallas en el proceso de comunicación e inspección. Se sugiere que debe haber un mayor compromiso del Gobierno con el fin de intensificar la vigilancia y hacer más comprensibles las responsabilidades de los agricultores.PALABRAS CLAVE: Logística inversa, las comunicaciones y la agroindustria, los envases de plaguicidas vacíos de la legislación ambiental. ReferênciasAnonymous. IBGE investiga o meio ambiente de 5.560 municipios brasileiros. Source: IPS. NoticiasFinancieras, Miami, p. 1, May 16 2005.BERLO, David. O processo de comunicação: introdução à teoria e à prática. São Paulo: Martins Fontes, 2003.BIGATÃO, Daniely Aparecida Reveillau. Cuidados e destinação final de embalagens, na utilização de agrotóxicos por produtores rurais no município de Itaporã - MS. Dissertação (Mestrado em Ciências da Saúde)-Universidade de Brasília, 2009.BOLDRIN, Vitor Paulo et al. A Gestão Ambiental e a Logística Reversa no Processo de Retorno de Embalagens de Agrotóxicos Vazias. RAI - Revista de Administração e Inovação, São Paulo, v. 4, n. 2, p. 29-48, 2007.BRAGA JUNIOR, Walter; ROMANIELLO, Marcelo Marcio. Direito Ambiental: Percepção dos agentes envolvidos na destinação final das embalagens de agrotóxicos, de acordo com a Lei n. 9.974/00, na região cafeeira do município de Lavras, no sul de Minas Gerais. Gestão &amp; Regionalidade (online), v. 24, n. 69, jan-abr/2008.BRASIL. Decreto nº 3.550, de 27/07/2000. Dá nova redação a dispositivos do Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins. Disponível em &lt; https://www.planalto.gov.br/ccivil_03/decreto/d3550.htm &gt; Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.694, de 21/12/2000. Altera e inclui dispositivos ao Decreto no 98.816 de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos, e dá outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/decreto/D3694.htm &gt; Acesso em 12 mar. 2015.BRASIL. Decreto nº 3.828, de 31/05/2001. Altera e inclui dispositivos ao Decreto no 98.816, de 11 de janeiro de 1990, que dispõe sobre o controle e a fiscalização de agrotóxicos e da outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/decreto/2001/D3828.htm &gt; Acesso em 12 mar. 2015BRASIL. Decreto nº 4.074, de 04/01/2002. Regulamenta a Lei nº 7.802, de 11 de julho de 1989. Disponível em &lt; https://www.planalto.gov.br/ccivil_03/decreto/2002/d4074.htm&gt; Acesso em 12 mar. 2015.BRASIL. Decreto nº 98.816, de 11/01/1990. Regulamenta a Lei 7.802/1989 e dá outras providências. Disponível em &lt; https://www.planalto.gov.br/ccivil_03/decreto/antigos/d98816.htm&gt; Acesso em 12 mar. 2015.BRASIL. Lei Federal nº 12.305, de 02/08/2010. Institui a Política Nacional de Resíduos Sólidos; altera a Lei no 9.605, de 12 de fevereiro de 1998; e dá outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/_ato2007-2010/2010/lei/l12305.htm&gt; Acesso em 05 set. 2014.BRASIL. Lei nº 6.938, de 31/08/1981. Dispõe sobre a Política Nacional do Meio Ambiente, seus fins e mecanismos de formulação e aplicação, e dá outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/leis/l6938.htm &gt; Acesso em 04 set. 2014.BRASIL. Lei nº 7.802/1989, de 11/07/1989. Dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em https://www.planalto.gov.br/ccivil_03/leis/l7802.htm Acesso em 03 fev. 2015.BRASIL. Lei nº 9.605, de 12/02/1998. Dispõe sobre as sanções penais e administrativas derivadas de condutas e atividades lesivas ao meio ambiente, e dá outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/leis/l9605.htm &gt; Acesso em 27 mar. 2015.BRASIL. Lei nº 9.974, de 06/06/2000. Altera a Lei nº 7.802/1989, que dispõe sobre a pesquisa, a experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Disponível em &lt; http://www.planalto.gov.br/ccivil_03/leis/L9974.htm&gt; Acesso em 12 mar. 2015.BRASIL. Resolução CONAMA nº 334, de 3 de abril de 2003. Dispõe sobre os procedimentos de licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens vazias de agrotóxicos. Disponível em &lt; http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=356&gt; Acesso em 20 mar. 2015.BRASIL. Resolução CONAMA nº 465, de 05/12/2014. Dispõe sobre os requisitos e critérios técnicos mínimos necessários para o licenciamento ambiental de estabelecimentos destinados ao recebimento de embalagens de agrotóxicos e afins, vazias ou contendo resíduos. Disponível em &lt; http://www.mma.gov.br/port/conama/legiabre.cfm?codlegi=710&gt; Acesso em 20 mar. 2015.CANTOS, Clotilde; MIRANDA, Zoraide Amarante I.; LICCO, Eduardo Antonio. Contribuições para a Gestão das Embalagens Vazias de Agrotóxicos. ©INTERFACEHS - Revista de Gestão Integrada em Saúde do Trabalho e Meio Ambiente - v.3, n.2, Seção Interfacehs 1, abr./ agosto. 2008 www.interfacehs.sp.senac.br.CARBONI, Gleriani Torres; SATO, Geni Satiko; MOORI, Roberto Giro. Logística Reversa para Embalagens de Agrotóxicos no Brasil: Uma Visão sobre Conceitos e Práticas Operacionais. XLIII CONGRESSO DA SOBER "Instituições, Eficiência, Gestão e Contratos no Sistema Agroindustrial". Ribeirão Preto, 24 a 27 de Julho de 2005.COMETTI, José Luís Said. 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&lt;p&gt;La Academia Panameña de Medicina y Cirugía, se siente honrada, en resaltar la figura de uno de sus miembros distinguidos, el Académico Titular José Manuel Fábrega Sosa, MD, FACS, FSSO, APMC. Este distinguido cirujano, panameño, hizo sus estudios profesionales en la Universidad de Notre Dame, Notre Dame, Indiana donde se graduó con honores siendo miembro de la Sociedad de honor AlphaEpsilonDelta. Continuó sus estudios de medicina en la George Washington University School of Medicine, Washington, DC., donde obtuvo el grado de Medicina, graduándose también con honores siendo nombrado en la Sociedad de Honor de Medicina de los Estados Unidos, AlphaOmegaAlpha. Hizo su residencia en cirugía en el New York Hospital Cornell Medical Center y en Oncología Quirúrgica en el Memorial Sloan Kettering Cancer Center de Nueva York. Ha sido Certificado y Recertificado por el American Board of Surgery. Fellow y ExGobernador del American College of Surgeons y Ex Presidente del Capítulo de Panamá del American College of Surgeons. Además de Fellow de la Society of Surgical Oncology. A nivel local, entre otros es Ex Presidente de la Academia Panameña de Medicina y Cirugía. Y Profesor Extraordinario de Cirugía, de la Facultad de Medicina, de la Universidad de Panamá. Presidente y miembro fundador de la Asociación Panameña de Cirugía Oncológica (APCO). Aparte de tener licencia en la República de Panamá, tiene licencia del estado de California y de Washington DC en los Estados Unidos. Recientemente, ha sido merecedor a un reconocimiento, reservado para pocos cirujanos destacados, en el mundo, ser reconocido como Honorary Fellow del American College of Surgeons (Colegio Americano de Cirujanos), luego de 43 años de brindar sus conocimientos para el cuidado y bienestar de sus pacientes. Cabe destacar que al presente Solo hay 487 cirujanos en el mundo entero que han recibido tal distinción. El Colegio Americano de Cirujanos otorga este honor cada año, a cuatro o cinco candidatos que han prestado servicios humanitarios, especialmente en el campo de la ciencia médica. Es el tercer panameño en recibir este reconocimiento; el primero en ser distinguido fue el doctor Augusto S. Boyd, en 1923; luego el neurólogo Antonio González Revilla, en 1973. La universidad de Cornell, de donde egresó, lo declaró exalumno meritorio y es el único egresado en recibir esa distinción. En Panamá; la Asamblea Nacional lo reconoció como ciudadano ejemplar y meritorio y el presidente de la república lo condecoró con la Orden Manuel Amador Guerrero en el “Grado de Gran Cruz”. Honrar, honra, y la Academia Panameña de Medicina y Cirugía, y La Revista Médica de Panamá, se enorgullecen de presentar a este ilustre panameño y latinoamericano.&lt;/p&gt;&lt;p&gt;ABSTRACT&lt;/p&gt;&lt;p&gt;The Panamanian Academy of Medicine and Surgery is honored to highlight the figure of one of its distinguished members, the Tenured Academician José Manuel Fábrega Sosa, MD, FACS, FSSO, APMC. This distinguished Panamanian surgeon did his professional studies at the University of Notre Dame, Notre Dame, Indiana where he graduated with honors as a member of the AlphaEpsilonDelta Honor Society. He continued his medical studies at the George Washington University School of Medicine, Washington, DC., Where he obtained a degree in Medicine, also graduating with honors and being named in the American Honor Society of Medicine, AlphaOmegaAlpha. He did his residency in surgery at New York Hospital Cornell Medical Center and in Surgical Oncology at Memorial Sloan Kettering Cancer Center in New York. He has been Certified and Recertified by the American Board of Surgery. Fellow and Former Governor of the American College of Surgeons and Former President of the Panama Chapter of the American College of Surgeons. In addition to Fellow of the Society of Surgical Oncology. At the local level, among others, he is Former President of the Panamanian Academy of Medicine and Surgery. And Extraordinary Professor of Surgery, Faculty of Medicine, University of Panama.&lt;/p&gt;&lt;p&gt;President and founding member of the Panamanian Association of Oncological Surgery (APCO). Apart from being licensed in the Republic of Panama, it is licensed by the state of California and Washington DC in the United States. Recently, he has been worthy of a recognition, reserved for few outstanding surgeons, in the world, being recognized as Honorary Fellow of the American College of Surgeons (American College of Surgeons), after 43 years of providing his knowledge for the care and well-being of your patients. It should be noted that there are currently only 487 surgeons worldwide who have received such a distinction. The American College of Surgeons awards this honor each year to four or five candidates who have provided humanitarian services, especially in the field of medical science. He is the third Panamanian to receive this recognition; the first to be distinguished was Dr. Augusto S. Boyd, in 1923, then the neurologist Antonio González Revilla, in 1973. Cornell University, where he graduated, declared him a meritorious alumnus and is the only graduate to receive that distinction. In Panama, the National Assembly recognized him as an exemplary and meritorious citizen and the President of the Republic decorated him with the Manuel Amador Guerrero Order in the “Grand Cross Degree”. Honor, honor, and the Panamanian Academy of Medicine and Surgery, and La Revista Médica de Panama, are proud to present this illustrious Panamanian and Latin American.&lt;/p&gt;

La Academia Panameña de Medicina y Cirugía, se siente honrada, en resaltar la figura de uno de sus miembros distinguidos, el Académico Titular José Manuel Fábrega Sosa, MD, FACS, FSSO, APMC. Este distinguido cirujano, panameño, hizo sus estudios profesionales en la Universidad de Notre Dame, Notre Dame, Indiana donde se graduó con honores siendo miembro de la Sociedad de honor AlphaEpsilonDelta. Continuó sus estudios de medicina en la George Washington University School of Medicine, Washington, DC., donde obtuvo el grado de Medicina, graduándose también con honores siendo nombrado en la Sociedad de Honor de Medicina de los Estados Unidos, AlphaOmegaAlpha. Hizo su residencia en cirugía en el New York Hospital Cornell Medical Center y en Oncología Quirúrgica en el Memorial Sloan Kettering Cancer Center de Nueva York. Ha sido Certificado y Recertificado por el American Board of Surgery. Fellow y ExGobernador del American College of Surgeons y Ex Presidente del Capítulo de Panamá del American College of Surgeons. Además de Fellow de la Society of Surgical Oncology. A nivel local, entre otros es Ex Presidente de la Academia Panameña de Medicina y Cirugía. Y Profesor Extraordinario de Cirugía, de la Facultad de Medicina, de la Universidad de Panamá. Presidente y miembro fundador de la Asociación Panameña de Cirugía Oncológica (APCO). Aparte de tener licencia en la República de Panamá, tiene licencia del estado de California y de Washington DC en los Estados Unidos. Recientemente, ha sido merecedor a un reconocimiento, reservado para pocos cirujanos destacados, en el mundo, ser reconocido como Honorary Fellow del American College of Surgeons (Colegio Americano de Cirujanos), luego de 43 años de brindar sus conocimientos para el cuidado y bienestar de sus pacientes. Cabe destacar que al presente Solo hay 487 cirujanos en el mundo entero que han recibido tal distinción. El Colegio Americano de Cirujanos otorga este honor cada año, a cuatro o cinco candidatos que han prestado servicios humanitarios, especialmente en el campo de la ciencia médica. Es el tercer panameño en recibir este reconocimiento; el primero en ser distinguido fue el doctor Augusto S. Boyd, en 1923; luego el neurólogo Antonio González Revilla, en 1973. La universidad de Cornell, de donde egresó, lo declaró exalumno meritorio y es el único egresado en recibir esa distinción. En Panamá; la Asamblea Nacional lo reconoció como ciudadano ejemplar y meritorio y el presidente de la república lo condecoró con la Orden Manuel Amador Guerrero en el “Grado de Gran Cruz”. Honrar, honra, y la Academia Panameña de Medicina y Cirugía, y La Revista Médica de Panamá, se enorgullecen de presentar a este ilustre panameño y latinoamericano.

Introducción. La rápida transición del medio rural a la adopción de hábitos alimenticios de zonas urbanas, el sedentarismo, las dificultades de acceso a la salud, ponen a la población en mayor riesgo de desarrollo de diabetes, sin embargo, son pocos los estudios que se enfocan en este fenómeno a nivel rural. Conocer el riesgo permite identificar las áreas problemáticas y revertir la situación a través de modelos de atención para esta población. El objetivo de este estudio fue describir los factores de riesgo presentes en una comunidad rural de Guanajuato. Material y Métodos: Estudio descriptivo, observacional, transversal; muestra no probabilística de 164 personas sin diabetes, se calculó con Epidat 3.1, intervalo de confianza al 95%, precisión del 3%; se aplicó el Cuestionario de Factores de Riesgo para la Diabetes Mellitus. Para la colecta se hizo un recorrido de casa por casa hasta completar la muestra, para el análisis estadístico se utilizó la chi cuadrada y cálculo de odds ratio. Resultados: El 71%(117) de la población fueron mujeres; el promedio para la edad fue de 43 años; el 85% de los sujetos presentaron un alto riesgo de padecer diabetes; los tres principales factores de riesgo fueron: 57.9% (95) con sobrepeso y obesidad, el 77.4%(127) de la muestra con cintura superior al parámetro recomendado, 75.6% (124) de la muestra presentó antecedentes heredofamiliares; en cuestión de género las mujeres presentaron 3 veces más riesgo de diabetes (p=&lt;.05). Conclusión: Los entornos rurales muy contrario a lo que se observaba, tienen alto riesgo de desarrollo de diabetes, probablemente va de la mano con los cambios de hábitos de las comunidades, pues la industrialización las ha invadido, con todo lo que conlleva, como lo señala Moreno L.&#x0D; Como citar este artículo: Avila Sansores Grever María, Vega Argote Ma. Gloria, Ruvalcaba Palacios Gerardo, Barreto Arias Ma. Eugenia, Gomez Aguilar Patricia Isolina, Yam Sosa Antonio Vicente. Riesgo de diabetes de una comunidad rural en México: un estudio observacional. Revista Cuidarte. 2020; 11(3): e797. http://dx.doi.org/10.15649/cuidarte.797 &#x0D;

Diversos mandatos del visitador diocesano y los pagos a los músicos dan cuenta de la actividad de la capilla de música de la parroquia de Nuestra Señora de la Asunción de El Barco de Ávila. Estaba formada por un maestro un organista y varios instrumentistas, más los mozos de coro y algún cantor. Various mandates of the diocesan visitor and the payments to the musicians account for the activity of the musis chapel of the parish of Nuestra Señora de la Asunción in El Barco de Ávila. It was made up of a chapelmaster, an organist and several instrumentalists, plus the choirs and some singer.

Reconstrucción parcial de los efectivos musicales de la catedral de Tuy (Pontevedra) durante el periodo 1582-1597, realizada a partir del Libro de cuentas de Fábrica (1582-1623) de esta institución conservado en la sección Clero del Archivo Histórico Nacional. Partial reconstruction of Tuy Cathedral (Pontevedra) musical resources during the period 1582-1597, made from the <em>Libro de cuentas de Fábrica</em> (1582-1623) of this institution preserved in the Clero section of the Archivo Histórico Nacional.&nbsp;