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Dissertations / Theses on the topic 'Aortic stenosi'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 March 2023

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1

Fraccaro, Chiara. "Transcatheter aortic valve implantation." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422130.

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Although surgery with prosthetic valve replacement is the gold standard for severe aortic stenosis (AS) treatment, there are still about one third of patients that are not operated because of inoperability criteria or high surgical risk. Therefore, with the ageing of global population, the lengthening in life-expectancy and the consequent growing need to treat elderly patients with severe AS, there is a wide population who would benefit from a less invasive way of replacing the aortic valve. Transcatheter aortic valve implantation (TAVI) allows the aortic valve to be implanted without a stern

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2

Rattazzi, Marcello. "Contribution of Interstitial Valve Cells to Aortic Valve Calcification." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425639.

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Background. The traditional view of aortic valve calcification as a slow, ineluctable event has been recently questioned by evidence showing the importance of a balance between promoting and inhibiting factors, and the relevance of osteogenic cellular-driven processes. The aortic valve leaflets are comprised of a heterogeneous population of interstitial cells (VIC) whose specific contribution to the degenerating valve has not been defined yet. Aim. The major aim is to identify and describe the phenotypic characteristics of a subpopulation of aortic VIC able to acquire a pro-calcific profile

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3

CLERICI, ALBERTO. "Development of a novel technology platform for thoracoscopic aortic valve replacement." Doctoral thesis, Politecnico di Torino, 2019. http://hdl.handle.net/11583/2745352.

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4

Ferrer, Sistach Elena. "Factors predictius d’esdeveniments en pacients amb estenosi valvular aòrtica severa asimptomàtica." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670501.

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L’Estenosi aòrtica (EAo) és la valvulopatia més comuna i que requereix amb més freqüència substitució valvular aòrtica (SVAo) en els països desenvolupats. La substitució valvular tant sigui per tècniques quirúrgiques com percutànies és l’únic tractament eficaç i aquest tractament està indicat quan hi ha símptomes associats o disfunció ventricular esquerra. En els últims anys, els bons resultats de la cirurgia cardíaca així com els significatius avenços de les tècniques percutànies han fet que ens plantegem el recanvi valvular aòrtic en fases més precoces de la malaltia, quan el pacient en

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5

Gripari, P. "MULTIMODALITY IMAGING ASSESSMENT OF THE ANATOMY OF THE AORTIC VALVE APPARATUS IN TAVI PATIENTS: IMPLICATIONS FOR PROSTHESIS SIZING AND PARAVALVULAR REGURGITATION." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/263404.

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Aortic stenosis (AS) has become the most frequent type of valvular heart disease in Europe and North America. As it primarily presents as calcific AS in adults of advanced age (2–7% of the population >65 years), its prevalence is expected to increase further in the future with an aging population. Severe AS is associated with debilitating symptoms (shortness of breath, angina, dizziness, or syncope), and reduced survival if left untreated. According to European Society of Cardiology guidelines, aortic valve replacement (AVR) is the definitive therapy for all patients with symptoms and seve

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6

McCann, Gerald Patrick. "Exercise limitation in aortic stenosis." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395082.

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7

Pawade, Tania Ashwinikumar. "Imaging calcification in aortic stenosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29589.

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BACKGROUND Aortic stenosis is a common and potentially fatal condition in which fibro-calcific changes within the valve leaflets lead to the obstruction of blood flow. Severe symptomatic stenosis is an indication for aortic valve replacement and timely referral is essential to prevent adverse clinical events. Calcification is believed to represent the central process driving disease progression. 18F-Fluoride positron emission tomography computed tomography (PET-CT) and CT aortic valve calcium scoring (CT-AVC) quantify calcification activity and burden respectively. The overarching aim of this

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8

Kattach, Hassan. "Blood pressure control in aortic stenosis." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526473.

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9

Rubino, A. S. (Antonino S. ). "Efficacy of the Perceval sutureless aortic valve bioprosthesis in the treatment of aortic valve stenosis." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212289.

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Abstract Aortic valve stenosis (AS) is one of the most diffuse valvular diseases in developed countries. AS is a progressive disease, which usually results in serious life-threatening adverse events. Defining a treatment strategy for AS is a focus of cardiovascular research, although the topic is still controversial because of its related clinical and economical implications. Surgical aortic valve replacement (AVR),which is regarded as the gold standard for the treatment of severe symptomatic AS, affords excellent results, particularly in asymptomatic patients with good functional status. AVR

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10

Lopez, Marco Ana. "Low-flow low-gradient aortic stenosis: outcomes after aortic valve replacement." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667817.

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Aortic stenosis is the commonest valve disorder in the Western World. The natural history of the disease is very well described; with a decreased survival once symptoms occur. There is currently, no medical therapy available to reduce the natural progression of the aortic stenosis, and therefore, aortic valve replacement has been recognised as the standard of care treatment for symptomatic aortic stenosis, with TAVI having merged as alternative for those cases with high/prohibitive surgical risk. All types of aortic stenosis have in common a reduced valve area (AVA <1.0cm2), but depending o

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11

Paul, Anup K. "Assessment of the Severity of Aortic Stenosis using Aortic Valve Coefficient." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470672658.

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12

Cowell, Sarah Joanna. "Lipid-lowering therapy in calcific aortic stenosis." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/29075.

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We hypothesised that (a) risk factors for atherosclerosis would predict, and (b) lipid lowering therapy would retard, disease progression and clinical outcome in patients with calcific aortic stenosis. Objectives: In patients with aortic stenosis, (i) to compare the magnitude and reproducibility of measures of valvular stenosis and calcification, (ii) to determine the effect of intensive lipid lowering therapy on disease progression and clinical outcome, and (iii) to describe predictors of disease progression and clinical outcome. Methods: In the Scottish Aortic stenosis and Lipid lowering The

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13

Das, Paul Kumar. "Prediction of symptom onset in aortic stenosis." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414771.

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14

Madan, Ashish. "In vitro assessment of the effects of valvular stenosis on aorta hemodynamics and left ventricular function." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527085221854915.

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15

Bull, Sacha Colette. "Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce.

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The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk that irreversible myocardial damage may occur with a conservative management strategy. It has become increasingly apparent that prognosis in asymptomatic AS depends not only on the degree of valvular stenosis, but also on the myocardial response to pressure overload and understanding the mechanisms of myocardial decompensation may help to guide management in the future. The degree of myocardial fibrosis, microvascular dysfunction, h

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16

Nyström-Rosander, Christina. "Chlamydia pneumoniae in aortic valve sclerosis and thoracic aortic disease : aspects of pathogenesis and therapy /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5356-2/.

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17

Bouma, Berto Jorrit. "Clinical decision making in elderly with aortic stenosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/78202.

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18

Sequeira, Gross Tatiana Maria [Verfasser]. "Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation / Tatiana Maria Sequeira Gross." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1234150387/34.

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19

Bagur, Rodrigo Hernan. "Transcatheter aortic valve implantation for the treatment of patients with severe symptomatic aortic stenosis." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29420/29420.pdf.

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20

Taniguchi, Tomohiko. "Initial Surgical VersusConservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225456.

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21

Peltonen, T. (Tuomas). "Endothelial factors in the pathogenesis of aortic valve stenosis." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289880.

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Abstract Calcified aortic valve disease represents a spectrum of disease spanning from mild aortic valve sclerosis to severe aortic valve stenosis (AS), being an actively regulated disease process and showing some hallmarks of atherosclerosis. The calcified aortic valve lesion develops endothelial injury and is characterized by inflammation, lipid accumulation, renin-angiotensin system activation and fibrosis. There is no approved pharmacological treatment available in AS. This study was aimed to characterize gene expression of endothelial factors in aortic valves in patients representing

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22

Rask, Peter. "Aortic stenosis : diagnostic use and hemodynamic effects of dipyridamole." Doctoral thesis, Umeå universitet, Klinisk fysiologi, 1995. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118692.

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23

Broyd, Christopher. "Coronary haemodynamics and wave intensity analysis in aortic stenosis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/23961.

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Introduction: Coronary Wave Intensity Analysis (WIA) provides an invasive measure of energy transfer within the coronary circulation. I set out to derive a non-invasive measure of the backward expansion wave (BEW) responsible for coronary flow and assess it during exercise and in aortic stenosis (AS). Methods: 17 patients (mean age 60, 11 male) with normal cardiac function underwent invasive LAD WIA calculation using a pressure- and flow-tipped wire. Non-invasive WIA was calculated immediately after angiography from simultaneous PW Doppler of the LAD and a suprasystolic-cuff derived measure of

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24

MOSCHETTA, DONATO. "UNRAVELLING SEX-DEPENDENT MECHANISMS IN CALCIFIC AORTIC VALVE STENOSIS." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/947275.

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Calcific aortic valve stenosis (CAVS) is the most common form of heart valve disease and affects about 3% of the population. Its prevalence increases with age, without a causal relation between ageing and CAVS development. To date, CAVS is a slow, progressive, multifactorial disorder considered to be actively driven by several cellular and molecular processes. Its natural history consists of a long clinically silent phase of non-uniform leaflet thickening with or without minimal calcification, known as aortic valve sclerosis (AVSc), without significant obstruction of blood flow, followed by th

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25

Park, Kenneth Stuart. "Stents for transcatheter aortic valve replacement." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27372.

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Rheumatic heart disease (RHD) is the leading cause of aortic valve disease in the world. Surgery to repair or replace the diseased valves is the only means to save a patient's life once the disease becomes symptomatic. Transcatheter aortic valve replacement (TAVR) has revolutionised the treatment of age-related degenerative aortic valve disease, but is currently not suitable for the majority of RHD sufferers due to the rapid degeneration of flexible leaflet valves in younger patients, contraindications of commercial devices to regurgitant or non-calcific aortic valve disease, and also due to r

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26

Miyake, Makoto. "Early Surgery vs. Surgery After Watchful Waiting for Asymptomatic Severe Aortic Stenosis." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264637.

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27

Musa, Tarique Al. "Transcatheter and surgical aortic valve replacement for severe aortic stenosis : insights from cardiovascular magnetic resonance imaging." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15238/.

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Background: Surgical aortic valve replacement (SAVR) remains first-line treatment for symptomatic severe aortic stenosis, whereas transcatheter aortic valve implantation (TAVI) is indicated in patients who are inoperable or considered too high-risk for surgery. Current focus is centred on differences in the impact of valve replacement upon cardiovascular function to guide patient selection and the development of novel prosthetic valves to improve outcomes. Cardiovascular Magnetic Resonance (CMR) imaging is the investigative modality of choice for such a purpose. Objectives: To compare the impa

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28

Bordoni, Barbara <1980&gt. "Balloon Aortic Valvuloplasty as Bridge-to-Decision in High Risk Patients with Severe Aortic Valve Stenosis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6892/1/Tesi_def_270315_3.pdf.

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Background. A sizable group of patients with symptomatic aortic stenosis (AS) can undergo neither surgical aortic valve replacement (AVR) nor transcatheter aortic valve implantation (TAVI) because of clinical contraindications. The aim of this study was to assess the potential role of balloon aortic valvuloplasty (BAV) as a “bridge-to-decision” in selected patients with severe AS and potentially reversible contraindications to definitive treatment. Methods. We retrospectively enrolled 645 patients who underwent first BAV at our Institution between July 2007 and December 2012. Of these, the

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29

Bordoni, Barbara <1980&gt. "Balloon Aortic Valvuloplasty as Bridge-to-Decision in High Risk Patients with Severe Aortic Valve Stenosis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6892/.

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Background. A sizable group of patients with symptomatic aortic stenosis (AS) can undergo neither surgical aortic valve replacement (AVR) nor transcatheter aortic valve implantation (TAVI) because of clinical contraindications. The aim of this study was to assess the potential role of balloon aortic valvuloplasty (BAV) as a “bridge-to-decision” in selected patients with severe AS and potentially reversible contraindications to definitive treatment. Methods. We retrospectively enrolled 645 patients who underwent first BAV at our Institution between July 2007 and December 2012. Of these, the

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30

Zhao, Ying. "Effect of valve replacement for aortic stenosis on ventricular function." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46809.

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Background：Aortic stenosis (AS) is the commonest valve disease in the West. Aortic valve replacement (AVR) remains the only available management for AS and results in improved symptoms and recovery of ventricular functions. In addition, it is well known that AVR results in disruption of LV function mainly in the form of reversal of septal motion as well as depression of right ventricular (RV) systolic function. The aim of this thesis was to study, in detail, the early and mid-term response of ventricular function to AVR procedures (surgical and TAVI) as well as post operative patients’ exercis

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31

Teien, Dag. "Assessment of aortic stenosis with special reference to Doppler ultrasound." Doctoral thesis, Umeå universitet, Klinisk fysiologi, 1986. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103813.

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32

Dweck, Marc Richard Leslie. "Assessment of aortic stenosis using modern non-invasive imaging techniques." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8136.

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Introduction. Aortic stenosis is characterised both by progressive narrowing of the valve and the hypertrophic response of the left ventricle. The purpose of this thesis was to study the contribution of inflammation and calcification to valve narrowing using Positron Emission and Computed Tomography (PET/CT) and to investigate the hypertrophic response using cardiovascular magnetic resonance (CMR). Methods. PET/CT studies. Patients with aortic sclerosis and mild, moderate and severe stenosis were prospectively compared to matched control subjects. Aortic valve severity was determined by echoca

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33

Treibel, Thomas Alexander. "Aortic stenosis : a myocardial disease : insights from myocardial tissue characterisation." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1574742/.

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Aortic stenosis (AS) is a disease of not just the valve, but also of the myocardium. Patient symptoms and outcome are determined by the myocardial response; a crucial but poorly understood process. Diffuse and focal myocardial fibrosis play a key role. Until recently, both could only be assessed using invasive histology, but now cardiovascular magnetic resonance (CMR) offers late gadolinium enhancement (LGE) and extracellular volume fraction (ECV) techniques. In this thesis, I developed new methods to quantify ECV by synthetic ECV and cardiac CT. I then explored myocardial remodelling and fibr

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34

Corona, Blanca Tovar. "Analysis and representation of heart sounds and murmurs." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299958.

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35

Hagen-Peter, Gayle Ann. "Living with Aortic Stenosis: A Phenomenological Study of Patients' Experiences and Subsequent Health Choices." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/516.

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Symptomatic aortic stenosis (AS) is an increasing phenomenon as more adults live longer. The gold standard for treating AS is surgical aortic valve replacement (SAVR). Frequently, as older individuals with AS often have multiple comorbidities, a SAVR is determined to be too high risk. Therefore, a less invasive treatment option is available, namely a transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR). Such biomedical procedures have encouraged life extension and the decision to intervene commonplace with the aging population. Without an intervention

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36

Kanamori, Norio. "Prognostic Impact of Aortic Valve Area in Conservatively Managed Patients With Asymptomatic Severe Aortic Stenosis With Preserved Ejection Fraction." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263349.

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37

Muta, Eri. "Impact of the left ventricular mass index on the outcomes of severe aortic stenosis." Kyoto University, 2019. http://hdl.handle.net/2433/242385.

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38

Ding, Wenhong. "Survival and functional recovery following valve replacement in patients with severe aortic stenosis." Doctoral thesis, Umeå universitet, Medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82644.

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Background: Aortic stenosis (AS) is the most common heart valve disease in Europe and North America. Age-related calcification of the valve is the commonest cause of acquired AS, especially in patients older than 70 years.Conventional surgical aortic valve replacement (SAVR) and the novel, minimally invasive transcatheter aortic valve implantation (TAVI), effectively preserve left ventricular (LV) function, relieve symptoms and improve survival in patients with severe symptomatic AS. However, patients with impaired LV function may carry significant operative risk, and long recovery time. In ad

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39

Wang, Qian. "Patient-specific finite element modeling of biomechanical interaction in transcatheter aortic valve implantation." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54849.

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Transcatheter aortic valve implantation (TAVI) is an effective alternative treatment option for patients with severe aortic stenosis, who are at a high risk for conventional surgical aortic valve replacement or considered inoperable. Despite the short- and mid-term survival benefits of TAVI, adverse clinical events, such as paravalvular leak, aortic rupture, and coronary occlusion, have been reported extensively. Many of these adverse events can be explained from the biomechanics perspective. Therefore, an in-depth understanding of biomechanical interaction between the device and native tissue

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40

Kumar, Anirudh. "SAFETY AND EFFICACY OF BALLOON AORTIC VALVULOPLASTY STRATIFIED BY ACUITY OF PATIENT ILLNESS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623349720127583.

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41

Fairbairn, Tim. "Severe aortic valve stenosis and the consequences of transcatheter and surgical aortic valve replacement : a cardiovascular magnetic resonance study." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5853/.

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Background: Severe symptomatic aortic stenosis (AS) heralds a poor prognostic outlook and significant co-morbidity, with valve replacement the only definitive cure. Transcatheter aortic valve implantation (TAVI) has developed as an alternative to the standard treatment of surgical aortic valve replacement (SAVR) in high-risk or inoperable AS patients. The clinical and cost effectiveness of TAVI compared to SAVR requires further investigation. Methods: A prospective study of sixty seven TAVI and twenty seven SAVR patients, recruited from September 2009 to September 2011. Baseline assessments in

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42

Ahlén, Caroline. "Outcome of patients with severe aortic stenosis – A retrospective follow-up study." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9372.

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<p>Aortic stenosis is the most common valvular disease in the adult population. A significant aortic stenosis is a serious condition, and if a symptomatic patient is not operated on, it may in most cases cause death. We have examined how many aortic stenoses that were diagnosed during one year, and a follow-up of the patients was also performed. We found 77 patients with significant aortic stenosis with a mean age of 76±13 years. At the time of follow-up 30 (39%) patients, aged between 29-85 years, had been surgically treated with implantation of a valve prosthesis within 2-23 months after the

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43

Low, See W., Justin Z. Lee, and Kwan S. Lee. "Abdominal aortic peripheral intervention to facilitate intra-aortic balloon pump support during high risk percutaneous coronary intervention: a case report." BMC, 2015. http://hdl.handle.net/10150/617182.

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UA Open Access Publishing Fund<br>Background: The use of intra-aortic balloon pump (IABP) via the trans-femoral approach has been established for hemodynamic support in patients undergoing high-risk percutaneous coronary intervention (PCI). However, there are various challenges associated with its use, especially in patients with aortoiliac occlusive arterial disease. Case presentation: We describe a case of high-risk PCI with IABP support complicated by intra-procedural detection of severe abdominal aortic stenosis that was successfully overcome with angioplasty of the stenotic lesion. C

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44

Alkhalil, Ahmad. "Outcomes Of Early Versus Late Discharge In Transfemoral Transcatheter Aortic Valve Replacement Via Minimally Invasive Strategy: A Propensity-Matched Analysis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1465592493.

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45

Jashari, Haki. "The effect of pressure afterload due to aortic coarctation on left ventricular function in children." Doctoral thesis, Umeå universitet, Medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128126.

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Background: Coarctation of the aorta (CoA) is a congenital heart disease which represents a narrowing of the proximal descending aorta, hence increasing pressure afterload to the left ventricle (LV). Conventional treatment of native CoA is surgical repair, however potential recurrence or other related complications e.g. aortic rupture, heart failure and cerebrovascular events are common. Thus, lifelong follow-up of these patients is required. Echocardiography is the most patient’s friendly method to evaluate CoA and in particular its effect on LV function. Moreover, the novel speckle tracking

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46

Heinrich, Russell Shawn. "Assessment of the fluid mechanics of aortic valve stenosis with in vitro modeling and control volume analysis." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/16664.

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47

Yap, Sing-Chien. "Congenital aortic stenosis in adults update on clinical outcome, diagnostic methods and pregnancy /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10863.

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48

Mikus, Elisa <1977&gt. "Trattamento della stenosi valvolare aortica: nuovi scenari dalla biologia molecolare alle nuove tecnologie." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10026/1/Frontespizio%20e%20tesi%20definitiva%20in%20pdf.pdf.

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La stenosi valvolare aortica è la più frequente patologia valvolare cardiaca nei paesi sviluppati come diretta conseguenza dell’aumentata aspettativa di vita. In Europa si stima che il numero di soggetti sintomatici per stenosi valvolare aortica aumenterà da 1.3 milioni nel 2025 a 2.1 milioni in 2050. Di conseguenza la stenosi aortica ha e avrà un forte impatto sulla salute pubblica e sui costi che ne determina, poiché spesso associata a un declino funzionale dei pazienti ed aumentata incidenza di ospedalizzazione. D’altra parte è noto che la stenosi valvolare aortica severa non trattata si as

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49

Larson, Blake E. "Magnetic resonance imaging based percent stenosis and pressure drop measurements in an aortic coarctation model." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/15976.

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50

Steadman, Christopher David. "Contribution of left ventricular hypertrophy to symptoms and exercise intolerance in severe aortic stenosis." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/38103.

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Background: Mechanisms governing symptoms and exercise intolerance in aortic stenosis (AS) are poorly understood. AS is characterised by left ventricular (LV) pressure overload leading to left ventricular hypertrophy, but the response is extremely variable. Our hypothesis was patients with high LV mass index (LVMI) would have more limitation before aortic valve replacement (AVR), and less improvement post-‐AVR. Methods: Investigations were performed pre‐ and 6 months post‐AVR; transthoracic echocardiography (TTE): stenosis severity/diastolic function; cardiopulmonary exercise testing (CPEX):

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